-- dump date 20140619_064409 -- class Genbank::misc_feature -- table misc_feature_note -- id note 1121451000001 Baseplate J-like protein; Region: Baseplate_J; cl01294 1121451000002 Phage tail protein (Tail_P2_I); Region: Tail_P2_I; pfam09684 1121451000003 AAA domain; Region: AAA_13; pfam13166 1121451000004 Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432 1121451000005 RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169 1121451000006 conjugal transfer relaxosome component TraJ; Provisional; Region: PRK13877 1121451000007 Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; pfam09669 1121451000008 Fic family protein [Function unknown]; Region: COG3177 1121451000009 Fic/DOC family N-terminal; Region: Fic_N; pfam13784 1121451000010 Fic/DOC family; Region: Fic; pfam02661 1121451000011 integrase; Provisional; Region: PRK09692 1121451000012 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 1121451000013 active site 1121451000014 Int/Topo IB signature motif; other site 1121451000015 Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432 1121451000016 TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029 1121451000017 active site 1121451000018 metal binding site [ion binding]; metal-binding site 1121451000019 interdomain interaction site; other site 1121451000020 AAA domain; Region: AAA_25; pfam13481 1121451000021 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1121451000022 Walker A motif; other site 1121451000023 ATP binding site [chemical binding]; other site 1121451000024 Walker B motif; other site 1121451000025 Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; cl17523 1121451000026 Predicted transcriptional regulator [Transcription]; Region: COG3905 1121451000027 Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016 1121451000028 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 1121451000029 Integrase core domain; Region: rve_3; pfam13683 1121451000030 HTH-like domain; Region: HTH_21; pfam13276 1121451000031 Integrase core domain; Region: rve; pfam00665 1121451000032 Integrase core domain; Region: rve_3; pfam13683 1121451000033 Transposase; Region: HTH_Tnp_1; pfam01527 1121451000034 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 1121451000035 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 1121451000036 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 1121451000037 putative active site [active] 1121451000038 putative NTP binding site [chemical binding]; other site 1121451000039 putative nucleic acid binding site [nucleotide binding]; other site 1121451000040 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cd09634 1121451000041 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725 1121451000042 CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cl17214 1121451000043 CRISPR/Cas system-associated protein Cmr5; Region: Cmr5_III-B; cl01317 1121451000044 CRISPR system related protein, RAMP superfamily [Defense mechanisms]; Region: COG1336 1121451000045 CRISPR-associated protein (Cas_Cmr3); Region: Cas_Cmr3; pfam09700 1121451000046 CRISPR/Cas system-associated RAMP superfamily protein Cmr3; Region: Cmr3_III-B; cl12075 1121451000047 CRISPR-associated protein Cas10/Cmr2, subtype III-B; Region: cas_TM1794_Cmr2; TIGR02577 1121451000048 CRISPR-associated protein; Region: DUF3692; pfam12469 1121451000049 CRISPR/Cas system-associated protein Cas10; Region: Cas10_III; cl13853 1121451000050 CRISPR/Cas system-associated RAMP superfamily protein Cmr1; Region: Cmr1_III-B; cl17436 1121451000051 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1121451000052 Na/Pi-cotransporter; Region: NaPi_cotrn_rel; TIGR00704 1121451000053 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 1121451000054 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 1121451000055 Outer membrane protein (OmpH-like); Region: OmpH; pfam03938 1121451000056 Pyruvate kinase [Carbohydrate transport and metabolism]; Region: PykF; COG0469 1121451000057 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 1121451000058 domain interfaces; other site 1121451000059 active site 1121451000060 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 1121451000061 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 1121451000062 dimer interface [polypeptide binding]; other site 1121451000063 putative anticodon binding site; other site 1121451000064 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 1121451000065 motif 1; other site 1121451000066 active site 1121451000067 motif 2; other site 1121451000068 motif 3; other site 1121451000069 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 1121451000070 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1121451000071 FtsX-like permease family; Region: FtsX; pfam02687 1121451000072 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1121451000073 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1121451000074 Walker A/P-loop; other site 1121451000075 ATP binding site [chemical binding]; other site 1121451000076 Q-loop/lid; other site 1121451000077 ABC transporter signature motif; other site 1121451000078 Walker B; other site 1121451000079 D-loop; other site 1121451000080 H-loop/switch region; other site 1121451000081 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1121451000082 outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303 1121451000083 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1121451000084 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1121451000085 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1121451000086 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1121451000087 Surface antigen; Region: Bac_surface_Ag; pfam01103 1121451000088 Outer membrane protein (OmpH-like); Region: OmpH; pfam03938 1121451000089 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 1121451000090 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 1121451000091 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 1121451000092 trimer interface [polypeptide binding]; other site 1121451000093 active site 1121451000094 UDP-GlcNAc binding site [chemical binding]; other site 1121451000095 lipid binding site [chemical binding]; lipid-binding site 1121451000096 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 1121451000097 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 1121451000098 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 1121451000099 active site 1121451000100 Protein of unknown function (DUF1009); Region: DUF1009; pfam06230 1121451000101 putative regulatory protein, FmdB family; Region: CxxC_CxxC_SSSS; TIGR02605 1121451000102 CGGC domain; Region: CGGC; cl02356 1121451000103 MinD superfamily P-loop ATPase containing an inserted ferredoxin domain [Energy production and conversion]; Region: COG1149 1121451000104 This protein family's function is unkown. It contains nucleotide binding site. It uses NTP as energy source to transfer electron or ion; Region: Fer4_NifH_child; cd03110 1121451000105 P loop nucleotide binding; other site 1121451000106 switch II; other site 1121451000107 MinD superfamily P-loop ATPase containing an inserted ferredoxin domain [Energy production and conversion]; Region: COG1149 1121451000108 This protein family's function is unkown. It contains nucleotide binding site. It uses NTP as energy source to transfer electron or ion; Region: Fer4_NifH_child; cd03110 1121451000109 P loop nucleotide binding; other site 1121451000110 switch II; other site 1121451000111 Protein of unknown function DUF89; Region: DUF89; cl15397 1121451000112 AsmA family; Region: AsmA; pfam05170 1121451000113 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 1121451000114 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 1121451000115 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 1121451000116 Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322 1121451000117 Na binding site [ion binding]; other site 1121451000118 probable sodium:solute symporter, VC_2705 subfamily; Region: Na_symport_lg; TIGR03648 1121451000119 glutamate dehydrogenase; Provisional; Region: PRK09414 1121451000120 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 1121451000121 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 1121451000122 NAD(P) binding site [chemical binding]; other site 1121451000123 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1121451000124 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121451000125 active site 1121451000126 phosphorylation site [posttranslational modification] 1121451000127 intermolecular recognition site; other site 1121451000128 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 1121451000129 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1121451000130 anti sigma factor interaction site; other site 1121451000131 regulatory phosphorylation site [posttranslational modification]; other site 1121451000132 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1121451000133 anti sigma factor interaction site; other site 1121451000134 regulatory phosphorylation site [posttranslational modification]; other site 1121451000135 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 1121451000136 Protein export membrane protein; Region: SecD_SecF; cl14618 1121451000137 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1121451000138 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1121451000139 HlyD family secretion protein; Region: HlyD_3; pfam13437 1121451000140 Predicted kinase related to dihydroxyacetone kinase [General function prediction only]; Region: COG1461 1121451000141 DAK2 domain; Region: Dak2; pfam02734 1121451000142 EDD domain protein, DegV family; Region: DegV; TIGR00762 1121451000143 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 1121451000144 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1121451000145 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1121451000146 Walker A/P-loop; other site 1121451000147 ATP binding site [chemical binding]; other site 1121451000148 Q-loop/lid; other site 1121451000149 ABC transporter signature motif; other site 1121451000150 Walker B; other site 1121451000151 D-loop; other site 1121451000152 H-loop/switch region; other site 1121451000153 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1121451000154 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1121451000155 substrate binding pocket [chemical binding]; other site 1121451000156 membrane-bound complex binding site; other site 1121451000157 hinge residues; other site 1121451000158 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1121451000159 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1121451000160 dimer interface [polypeptide binding]; other site 1121451000161 conserved gate region; other site 1121451000162 putative PBP binding loops; other site 1121451000163 ABC-ATPase subunit interface; other site 1121451000164 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1121451000165 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1121451000166 dimer interface [polypeptide binding]; other site 1121451000167 conserved gate region; other site 1121451000168 putative PBP binding loops; other site 1121451000169 ABC-ATPase subunit interface; other site 1121451000170 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 1121451000171 intersubunit interface [polypeptide binding]; other site 1121451000172 active site 1121451000173 catalytic residue [active] 1121451000174 cobalt-precorrin-8X methylmutase; Validated; Region: cbiC; cl00913 1121451000175 Precorrin-8X methylmutase; Region: CbiC; pfam02570 1121451000176 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1121451000177 dimerization interface [polypeptide binding]; other site 1121451000178 PAS domain S-box; Region: sensory_box; TIGR00229 1121451000179 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1121451000180 putative active site [active] 1121451000181 heme pocket [chemical binding]; other site 1121451000182 PAS domain S-box; Region: sensory_box; TIGR00229 1121451000183 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 1121451000184 putative active site [active] 1121451000185 heme pocket [chemical binding]; other site 1121451000186 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1121451000187 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1121451000188 metal binding site [ion binding]; metal-binding site 1121451000189 active site 1121451000190 I-site; other site 1121451000191 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1121451000192 Ferredoxin [Energy production and conversion]; Region: COG1146 1121451000193 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 1121451000194 2-oxoglutarate ferredoxin oxidoreductase subunit alpha; Validated; Region: PRK08659 1121451000195 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 1121451000196 dimer interface [polypeptide binding]; other site 1121451000197 PYR/PP interface [polypeptide binding]; other site 1121451000198 TPP binding site [chemical binding]; other site 1121451000199 substrate binding site [chemical binding]; other site 1121451000200 2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867 1121451000201 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 1121451000202 TPP-binding site [chemical binding]; other site 1121451000203 2-oxoglutarate ferredoxin oxidoreductase subunit gamma; Validated; Region: PRK08537 1121451000204 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546 1121451000205 Transcriptional regulator containing GAF, AAA-type ATPase, and DNA binding domains [Transcription / Signal transduction mechanisms]; Region: FhlA; COG3604 1121451000206 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1121451000207 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1121451000208 Walker A motif; other site 1121451000209 ATP binding site [chemical binding]; other site 1121451000210 Walker B motif; other site 1121451000211 arginine finger; other site 1121451000212 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1121451000213 pyruvate/ketoisovalerate ferredoxin oxidoreductase subunit gamma; Provisional; Region: PRK14029 1121451000214 indolepyruvate oxidoreductase subunit beta; Reviewed; Region: PRK06853 1121451000215 indolepyruvate ferredoxin oxidoreductase, alpha subunit; Region: IOR_alpha; TIGR03336 1121451000216 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 1121451000217 dimer interface [polypeptide binding]; other site 1121451000218 PYR/PP interface [polypeptide binding]; other site 1121451000219 TPP binding site [chemical binding]; other site 1121451000220 substrate binding site [chemical binding]; other site 1121451000221 Thiamine pyrophosphate (TPP) family, IOR-alpha subfamily, TPP-binding module; composed of proteins similar to indolepyruvate ferredoxin oxidoreductase (IOR) alpha subunit. IOR catalyzes the oxidative decarboxylation of arylpyruvates, such as...; Region: TPP_IOR_alpha; cd02008 1121451000222 TPP-binding site; other site 1121451000223 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 1121451000224 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 1121451000225 putative catalytic cysteine [active] 1121451000226 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 1121451000227 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 1121451000228 active site 1121451000229 (T/H)XGH motif; other site 1121451000230 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 1121451000231 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 1121451000232 putative active site [active] 1121451000233 Domain of unknown function DUF21; Region: DUF21; pfam01595 1121451000234 FOG: CBS domain [General function prediction only]; Region: COG0517 1121451000235 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1121451000236 CcmE; Region: CcmE; cl00994 1121451000237 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: CcmF; COG1138 1121451000238 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1121451000239 cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13538 1121451000240 Walker A/P-loop; other site 1121451000241 ATP binding site [chemical binding]; other site 1121451000242 Q-loop/lid; other site 1121451000243 ABC transporter signature motif; other site 1121451000244 Walker B; other site 1121451000245 D-loop; other site 1121451000246 H-loop/switch region; other site 1121451000247 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 1121451000248 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1121451000249 binding surface 1121451000250 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1121451000251 TPR motif; other site 1121451000252 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 1121451000253 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 1121451000254 dimerization interface [polypeptide binding]; other site 1121451000255 ligand binding site [chemical binding]; other site 1121451000256 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1121451000257 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 1121451000258 TM-ABC transporter signature motif; other site 1121451000259 leucine/isoleucine/valine transporter permease subunit; Provisional; Region: livM; PRK11301 1121451000260 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 1121451000261 TM-ABC transporter signature motif; other site 1121451000262 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 1121451000263 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 1121451000264 Walker A/P-loop; other site 1121451000265 ATP binding site [chemical binding]; other site 1121451000266 Q-loop/lid; other site 1121451000267 ABC transporter signature motif; other site 1121451000268 Walker B; other site 1121451000269 D-loop; other site 1121451000270 H-loop/switch region; other site 1121451000271 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 1121451000272 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 1121451000273 Walker A/P-loop; other site 1121451000274 ATP binding site [chemical binding]; other site 1121451000275 Q-loop/lid; other site 1121451000276 ABC transporter signature motif; other site 1121451000277 Walker B; other site 1121451000278 D-loop; other site 1121451000279 H-loop/switch region; other site 1121451000280 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 1121451000281 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1121451000282 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 1121451000283 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 1121451000284 active site 1121451000285 GMP synthase; Reviewed; Region: guaA; PRK00074 1121451000286 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 1121451000287 AMP/PPi binding site [chemical binding]; other site 1121451000288 candidate oxyanion hole; other site 1121451000289 catalytic triad [active] 1121451000290 potential glutamine specificity residues [chemical binding]; other site 1121451000291 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 1121451000292 ATP Binding subdomain [chemical binding]; other site 1121451000293 Ligand Binding sites [chemical binding]; other site 1121451000294 Dimerization subdomain; other site 1121451000295 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 1121451000296 Sec-independent protein translocase protein (TatC); Region: TatC; pfam00902 1121451000297 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 1121451000298 putative active site pocket [active] 1121451000299 4-fold oligomerization interface [polypeptide binding]; other site 1121451000300 metal binding residues [ion binding]; metal-binding site 1121451000301 3-fold/trimer interface [polypeptide binding]; other site 1121451000302 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 1121451000303 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 1121451000304 catalytic residues [active] 1121451000305 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1121451000306 metal-binding site [ion binding] 1121451000307 Rubrerythrin [Energy production and conversion]; Region: COG1592 1121451000308 Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041 1121451000309 binuclear metal center [ion binding]; other site 1121451000310 Rubredoxin_like; nonheme iron binding domain containing a [Fe(SCys)4] center. The family includes rubredoxins, a small electron transfer protein, and a slightly smaller modular rubredoxin domain present in rubrerythrin and nigerythrin and detected either...; Region: rubredoxin_like; cl00202 1121451000311 iron binding site [ion binding]; other site 1121451000312 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 1121451000313 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 1121451000314 homodimer interface [polypeptide binding]; other site 1121451000315 metal binding site [ion binding]; metal-binding site 1121451000316 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 1121451000317 homodimer interface [polypeptide binding]; other site 1121451000318 active site 1121451000319 putative chemical substrate binding site [chemical binding]; other site 1121451000320 metal binding site [ion binding]; metal-binding site 1121451000321 Colicin V production protein; Region: Colicin_V; pfam02674 1121451000322 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908 1121451000323 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168 1121451000324 heme-binding residues [chemical binding]; other site 1121451000325 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 1121451000326 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1121451000327 molybdopterin cofactor binding site; other site 1121451000328 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 1121451000329 Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437 1121451000330 Polysulphide reductase [Energy production and conversion]; Region: COG5557; cl17901 1121451000331 Polysulphide reductase, NrfD; Region: NrfD; pfam03916 1121451000332 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1121451000333 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1121451000334 ligand binding site [chemical binding]; other site 1121451000335 flexible hinge region; other site 1121451000336 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1121451000337 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1121451000338 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 1121451000339 Walker A/P-loop; other site 1121451000340 ATP binding site [chemical binding]; other site 1121451000341 Q-loop/lid; other site 1121451000342 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4619 1121451000343 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1121451000344 ABC transporter signature motif; other site 1121451000345 Walker B; other site 1121451000346 D-loop; other site 1121451000347 H-loop/switch region; other site 1121451000348 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 1121451000349 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1121451000350 anti sigma factor interaction site; other site 1121451000351 regulatory phosphorylation site [posttranslational modification]; other site 1121451000352 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 1121451000353 active site residue [active] 1121451000354 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1121451000355 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1121451000356 Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703 1121451000357 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 1121451000358 ADP binding site [chemical binding]; other site 1121451000359 magnesium binding site [ion binding]; other site 1121451000360 putative shikimate binding site; other site 1121451000361 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 1121451000362 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 1121451000363 Tetramer interface [polypeptide binding]; other site 1121451000364 active site 1121451000365 FMN-binding site [chemical binding]; other site 1121451000366 Putative heavy-metal-binding; Region: YbjQ_1; pfam01906 1121451000367 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1121451000368 dimerization interface [polypeptide binding]; other site 1121451000369 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1121451000370 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1121451000371 dimer interface [polypeptide binding]; other site 1121451000372 phosphorylation site [posttranslational modification] 1121451000373 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1121451000374 ATP binding site [chemical binding]; other site 1121451000375 Mg2+ binding site [ion binding]; other site 1121451000376 G-X-G motif; other site 1121451000377 Response regulator receiver domain; Region: Response_reg; pfam00072 1121451000378 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121451000379 active site 1121451000380 phosphorylation site [posttranslational modification] 1121451000381 intermolecular recognition site; other site 1121451000382 dimerization interface [polypeptide binding]; other site 1121451000383 Response regulator receiver domain; Region: Response_reg; pfam00072 1121451000384 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121451000385 active site 1121451000386 phosphorylation site [posttranslational modification] 1121451000387 intermolecular recognition site; other site 1121451000388 dimerization interface [polypeptide binding]; other site 1121451000389 NAD synthetase; Provisional; Region: PRK13981 1121451000390 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 1121451000391 multimer interface [polypeptide binding]; other site 1121451000392 active site 1121451000393 catalytic triad [active] 1121451000394 protein interface 1 [polypeptide binding]; other site 1121451000395 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 1121451000396 homodimer interface [polypeptide binding]; other site 1121451000397 NAD binding pocket [chemical binding]; other site 1121451000398 ATP binding pocket [chemical binding]; other site 1121451000399 Mg binding site [ion binding]; other site 1121451000400 active-site loop [active] 1121451000401 Response regulator receiver domain; Region: Response_reg; pfam00072 1121451000402 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121451000403 active site 1121451000404 phosphorylation site [posttranslational modification] 1121451000405 intermolecular recognition site; other site 1121451000406 dimerization interface [polypeptide binding]; other site 1121451000407 HDOD domain; Region: HDOD; pfam08668 1121451000408 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1121451000409 Zn2+ binding site [ion binding]; other site 1121451000410 Mg2+ binding site [ion binding]; other site 1121451000411 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 1121451000412 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 1121451000413 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 1121451000414 active site 1121451000415 Protein of unknown function DUF115; Region: MAF_flag10; pfam01973 1121451000416 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1121451000417 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1121451000418 dimer interface [polypeptide binding]; other site 1121451000419 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1121451000420 catalytic residue [active] 1121451000421 Cysteinyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: CysS; COG0215 1121451000422 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 1121451000423 Predicted transmembrane sensor domain [Signal transduction mechanisms]; Region: COG4252 1121451000424 CHASE2 domain; Region: CHASE2; pfam05226 1121451000425 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1121451000426 cyclase homology domain; Region: CHD; cd07302 1121451000427 nucleotidyl binding site; other site 1121451000428 metal binding site [ion binding]; metal-binding site 1121451000429 dimer interface [polypeptide binding]; other site 1121451000430 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 1121451000431 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1121451000432 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1121451000433 Walker A/P-loop; other site 1121451000434 ATP binding site [chemical binding]; other site 1121451000435 Q-loop/lid; other site 1121451000436 ABC transporter signature motif; other site 1121451000437 Walker B; other site 1121451000438 D-loop; other site 1121451000439 H-loop/switch region; other site 1121451000440 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 1121451000441 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 1121451000442 HlyD family secretion protein; Region: HlyD_3; pfam13437 1121451000443 TPR repeat; Region: TPR_11; pfam13414 1121451000444 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1121451000445 TPR motif; other site 1121451000446 binding surface 1121451000447 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1121451000448 TPR repeat; Region: TPR_11; pfam13414 1121451000449 binding surface 1121451000450 TPR motif; other site 1121451000451 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1121451000452 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 1121451000453 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121451000454 Response regulator receiver domain; Region: Response_reg; pfam00072 1121451000455 active site 1121451000456 phosphorylation site [posttranslational modification] 1121451000457 intermolecular recognition site; other site 1121451000458 dimerization interface [polypeptide binding]; other site 1121451000459 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1121451000460 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1121451000461 ligand binding site [chemical binding]; other site 1121451000462 flexible hinge region; other site 1121451000463 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1121451000464 putative switch regulator; other site 1121451000465 non-specific DNA interactions [nucleotide binding]; other site 1121451000466 DNA binding site [nucleotide binding] 1121451000467 sequence specific DNA binding site [nucleotide binding]; other site 1121451000468 putative cAMP binding site [chemical binding]; other site 1121451000469 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 1121451000470 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 1121451000471 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 1121451000472 4Fe-4S single cluster domain; Region: Fer4_15; pfam13459 1121451000473 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 1121451000474 hybrid cluster protein; Provisional; Region: PRK05290 1121451000475 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1121451000476 ACS interaction site; other site 1121451000477 Hybrid cluster protein (HCP), formerly known as prismane, is thought to play a role in nitrogen metabolism but its specific function is unknown. HCP has three structural domains, an N-terminal alpha-helical domain, and two similar domains comprising a...; Region: HCP; cd01914 1121451000478 hybrid metal cluster; other site 1121451000479 purine nucleoside phosphorylase; Provisional; Region: PRK08202 1121451000480 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 1121451000481 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 1121451000482 Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360 1121451000483 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1121451000484 ligand binding site [chemical binding]; other site 1121451000485 PilZ domain; Region: PilZ; pfam07238 1121451000486 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1121451000487 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 1121451000488 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1121451000489 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1121451000490 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; pfam03255 1121451000491 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1121451000492 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1121451000493 urea carboxylase; Region: urea_carbox; TIGR02712 1121451000494 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1121451000495 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1121451000496 dimer interface [polypeptide binding]; other site 1121451000497 ssDNA binding site [nucleotide binding]; other site 1121451000498 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1121451000499 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 1121451000500 Nitrogen regulatory protein P-II; Region: P-II; smart00938 1121451000501 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 1121451000502 TPR repeat; Region: TPR_11; pfam13414 1121451000503 PilZ domain; Region: PilZ; pfam07238 1121451000504 PilZ domain; Region: PilZ; pfam07238 1121451000505 Bacterial SNF2 helicase associated; Region: SNF2_assoc; pfam08455 1121451000506 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 1121451000507 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1121451000508 ATP binding site [chemical binding]; other site 1121451000509 putative Mg++ binding site [ion binding]; other site 1121451000510 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1121451000511 nucleotide binding region [chemical binding]; other site 1121451000512 ATP-binding site [chemical binding]; other site 1121451000513 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1121451000514 The substrate-binding component of the oligopeptide-binding protein, AppA, from Bacillus subtilis contains the type 2 periplasmic-binding fold; Region: PBP2_AppA_like; cd08514 1121451000515 peptide binding site [polypeptide binding]; other site 1121451000516 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 1121451000517 HD domain; Region: HD_4; pfam13328 1121451000518 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1121451000519 synthetase active site [active] 1121451000520 NTP binding site [chemical binding]; other site 1121451000521 metal binding site [ion binding]; metal-binding site 1121451000522 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 1121451000523 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 1121451000524 Isochorismatase family; Region: Isochorismatase; pfam00857 1121451000525 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 1121451000526 catalytic triad [active] 1121451000527 conserved cis-peptide bond; other site 1121451000528 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1121451000529 Domain of unknown function (DUF1956); Region: DUF1956; pfam09209 1121451000530 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1121451000531 HlyD family secretion protein; Region: HlyD_3; pfam13437 1121451000532 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 1121451000533 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 1121451000534 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 1121451000535 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1121451000536 Ornithine/acetylornithine aminotransferase [Amino acid transport and metabolism]; Region: ArgD; COG4992 1121451000537 inhibitor-cofactor binding pocket; inhibition site 1121451000538 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1121451000539 catalytic residue [active] 1121451000540 hopanoid biosynthesis associated RND transporter like protein HpnN; Region: HpnN; TIGR03480 1121451000541 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 1121451000542 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1121451000543 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1121451000544 TPR motif; other site 1121451000545 hopanoid biosynthesis associated radical SAM protein HpnH; Region: HpnH; TIGR03470 1121451000546 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1121451000547 FeS/SAM binding site; other site 1121451000548 Domain of unknown function (DUF3463); Region: DUF3463; pfam11946 1121451000549 hopanoid-associated phosphorylase; Region: HpnG; TIGR03468 1121451000550 AAA domain; Region: AAA_32; pfam13654 1121451000551 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 1121451000552 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 1121451000553 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 1121451000554 putative dimer interface [polypeptide binding]; other site 1121451000555 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1121451000556 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1121451000557 substrate binding pocket [chemical binding]; other site 1121451000558 membrane-bound complex binding site; other site 1121451000559 hinge residues; other site 1121451000560 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1121451000561 dimer interface [polypeptide binding]; other site 1121451000562 conserved gate region; other site 1121451000563 putative PBP binding loops; other site 1121451000564 ABC-ATPase subunit interface; other site 1121451000565 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1121451000566 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1121451000567 Walker A/P-loop; other site 1121451000568 ATP binding site [chemical binding]; other site 1121451000569 Q-loop/lid; other site 1121451000570 ABC transporter signature motif; other site 1121451000571 Walker B; other site 1121451000572 D-loop; other site 1121451000573 H-loop/switch region; other site 1121451000574 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 1121451000575 Predicted membrane protein [Function unknown]; Region: COG1289 1121451000576 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 1121451000577 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1121451000578 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1121451000579 GtrA-like protein; Region: GtrA; pfam04138 1121451000580 Glucosyl transferase GtrII; Region: Glucos_trans_II; pfam14264 1121451000581 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 1121451000582 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 1121451000583 Ligand binding site; other site 1121451000584 Putative Catalytic site; other site 1121451000585 DXD motif; other site 1121451000586 Bacteriophage CI repressor helix-turn-helix domain; Region: Phage_CI_repr; pfam07022 1121451000587 Mu DNA-binding domain; Region: HTH_Tnp_Mu_1; pfam02316 1121451000588 Integrase core domain; Region: rve; pfam00665 1121451000589 Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299 1121451000590 AAA domain; Region: AAA_22; pfam13401 1121451000591 Protein of unknown function (DUF1018); Region: DUF1018; pfam06252 1121451000592 Mor transcription activator family; Region: Mor; cl02360 1121451000593 Protein of unknown function (DUF2730); Region: DUF2730; pfam10805 1121451000594 Phage virion morphogenesis family; Region: Phage_tail_S; cl02089 1121451000595 Phage-related baseplate assembly protein; Region: Phage_base_V; cl17812 1121451000596 Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; cl01733 1121451000597 Gene 25-like lysozyme; Region: GPW_gp25; cl01403 1121451000598 Baseplate J-like protein; Region: Baseplate_J; cl01294 1121451000599 Phage tail protein (Tail_P2_I); Region: Tail_P2_I; pfam09684 1121451000600 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 1121451000601 major tail sheath protein; Provisional; Region: FI; PHA02560 1121451000602 Phage tail tube protein FII; Region: Phage_tube; pfam04985 1121451000603 Mu-like prophage FluMu protein gp41; Region: FluMu_gp41; pfam10109 1121451000604 Phage P2 GpE; Region: Phage_P2_GpE; pfam06528 1121451000605 phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760 1121451000606 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 1121451000607 Na binding site [ion binding]; other site 1121451000608 Phage P2 GpU; Region: Phage_P2_GpU; pfam06995 1121451000609 Phage Tail Protein X; Region: Phage_tail_X; cl02088 1121451000610 Phage late control gene D protein (GPD); Region: Phage_GPD; cl15796 1121451000611 Integrase core domain; Region: rve; pfam00665 1121451000612 Transposase; Region: HTH_Tnp_1; pfam01527 1121451000613 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1121451000614 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1121451000615 Glycosyltransferase sugar-binding region containing DXD motif; Region: Gly_transf_sug; pfam04488 1121451000616 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 1121451000617 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1121451000618 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1121451000619 NAD(P) binding site [chemical binding]; other site 1121451000620 active site 1121451000621 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1121451000622 This family is most closely related to the GT1 family of glycosyltransferases. ExpE7 in Sinorhizobium meliloti has been shown to be involved in the biosynthesis of galactoglucans (exopolysaccharide II); Region: GT1_ExpE7_like; cd03823 1121451000623 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535 1121451000624 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1121451000625 FeS/SAM binding site; other site 1121451000626 Domain of unknown function (DUF4008); Region: DUF4008; pfam13186 1121451000627 C-20 methyltransferase BchU; Region: C20_methyl_CrtF; TIGR02716 1121451000628 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1121451000629 S-adenosylmethionine binding site [chemical binding]; other site 1121451000630 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 1121451000631 catalytic core [active] 1121451000632 WYL domain; Region: WYL; pfam13280 1121451000633 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 1121451000634 Divergent AAA domain; Region: AAA_4; pfam04326 1121451000635 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1121451000636 Transposase; Region: HTH_Tnp_1; pfam01527 1121451000637 HTH-like domain; Region: HTH_21; pfam13276 1121451000638 Integrase core domain; Region: rve; pfam00665 1121451000639 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 1121451000640 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 1121451000641 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 1121451000642 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 1121451000643 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 1121451000644 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 1121451000645 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 1121451000646 Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072 1121451000647 BsuBI/PstI restriction endonuclease C-terminus; Region: BsuBI_PstI_RE; pfam06616 1121451000648 type II restriction m6 adenine DNA methyltransferase, Alw26I/Eco31I/Esp3I family; Region: met_A_Alw26; TIGR02987 1121451000649 Methyltransferase domain; Region: Methyltransf_26; pfam13659 1121451000650 Helix-turn-helix domain; Region: HTH_17; pfam12728 1121451000651 Transposase; Region: HTH_Tnp_1; pfam01527 1121451000652 Site-specific recombinase XerC [DNA replication, recombination, and repair]; Region: XerC; COG4973 1121451000653 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 1121451000654 active site 1121451000655 catalytic residues [active] 1121451000656 DNA binding site [nucleotide binding] 1121451000657 Int/Topo IB signature motif; other site 1121451000658 Helix-turn-helix domain; Region: HTH_17; pfam12728 1121451000659 The accessory protein CooC, which contains a nucleotide-binding domain (P-loop) near the N-terminus, participates in the maturation of the nickel center of carbon monoxide dehydrogenase (CODH). CODH from Rhodospirillum rubrum catalyzes the reversible...; Region: CooC; cd02034 1121451000660 P-loop; other site 1121451000661 P-type conjugative transfer ATPase TrbB; Region: TrbB_P; TIGR02782 1121451000662 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 1121451000663 ATP binding site [chemical binding]; other site 1121451000664 Walker A motif; other site 1121451000665 hexamer interface [polypeptide binding]; other site 1121451000666 Walker B motif; other site 1121451000667 TrbC/VIRB2 family; Region: TrbC; pfam04956 1121451000668 P-type conjugative transfer ATPase TrbB; Region: TrbB_P; TIGR02782 1121451000669 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1121451000670 Walker A motif; other site 1121451000671 ATP binding site [chemical binding]; other site 1121451000672 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 1121451000673 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 1121451000674 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1121451000675 catalytic residue [active] 1121451000676 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 1121451000677 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 1121451000678 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1121451000679 S-adenosylmethionine binding site [chemical binding]; other site 1121451000680 TIGR01210 family protein; Region: TIGR01210 1121451000681 TIGR01210 family protein; Region: TIGR01210 1121451000682 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1121451000683 TIGR01210 family protein; Region: TIGR01210 1121451000684 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1121451000685 FeS/SAM binding site; other site 1121451000686 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1121451000687 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1121451000688 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1121451000689 AAA domain; Region: AAA_21; pfam13304 1121451000690 Walker A/P-loop; other site 1121451000691 ATP binding site [chemical binding]; other site 1121451000692 Q-loop/lid; other site 1121451000693 ABC transporter signature motif; other site 1121451000694 Walker B; other site 1121451000695 D-loop; other site 1121451000696 H-loop/switch region; other site 1121451000697 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 1121451000698 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1121451000699 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1121451000700 catalytic residue [active] 1121451000701 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1121451000702 Radical SAM superfamily; Region: Radical_SAM; pfam04055 1121451000703 FeS/SAM binding site; other site 1121451000704 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 1121451000705 active site 1121451000706 A predicted NlpC/p60-like peptidase; Region: BtrH; pfam14399 1121451000707 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 1121451000708 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1121451000709 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1121451000710 acyl-activating enzyme (AAE) consensus motif; other site 1121451000711 acyl-activating enzyme (AAE) consensus motif; other site 1121451000712 AMP binding site [chemical binding]; other site 1121451000713 active site 1121451000714 CoA binding site [chemical binding]; other site 1121451000715 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 1121451000716 NAD synthetase; Provisional; Region: PRK13980 1121451000717 Ligand Binding Site [chemical binding]; other site 1121451000718 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1121451000719 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 1121451000720 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 1121451000721 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 1121451000722 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1121451000723 ATP binding site [chemical binding]; other site 1121451000724 putative Mg++ binding site [ion binding]; other site 1121451000725 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 1121451000726 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 1121451000727 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 1121451000728 Protein of unknown function (Hypoth_ymh); Region: Hypoth_Ymh; pfam09509 1121451000729 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 1121451000730 HsdM N-terminal domain; Region: HsdM_N; pfam12161 1121451000731 Methyltransferase domain; Region: Methyltransf_26; pfam13659 1121451000732 DNA binding domain, excisionase family; Region: excise; TIGR01764 1121451000733 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 1121451000734 putative active site pocket [active] 1121451000735 dimerization interface [polypeptide binding]; other site 1121451000736 putative catalytic residue [active] 1121451000737 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cd00352 1121451000738 active site 1121451000739 Glutamine amidotransferase domain; Region: GATase_6; pfam13522 1121451000740 Putative amidoligase enzyme; Region: Amidoligase_2; pfam12224 1121451000741 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 1121451000742 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 1121451000743 catalytic residues [active] 1121451000744 catalytic nucleophile [active] 1121451000745 Presynaptic Site I dimer interface [polypeptide binding]; other site 1121451000746 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 1121451000747 Synaptic Flat tetramer interface [polypeptide binding]; other site 1121451000748 Synaptic Site I dimer interface [polypeptide binding]; other site 1121451000749 DNA binding site [nucleotide binding] 1121451000750 Recombinase; Region: Recombinase; pfam07508 1121451000751 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 1121451000752 Protein of unknown function (DUF2924); Region: DUF2924; pfam11149 1121451000753 Protein of unknown function (DUF2924); Region: DUF2924; pfam11149 1121451000754 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 1121451000755 LexA repressor; Validated; Region: PRK00215 1121451000756 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1121451000757 Catalytic site [active] 1121451000758 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1121451000759 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1121451000760 dimer interface [polypeptide binding]; other site 1121451000761 conserved gate region; other site 1121451000762 ABC-ATPase subunit interface; other site 1121451000763 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 1121451000764 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1121451000765 dimer interface [polypeptide binding]; other site 1121451000766 conserved gate region; other site 1121451000767 putative PBP binding loops; other site 1121451000768 ABC-ATPase subunit interface; other site 1121451000769 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 1121451000770 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 1121451000771 Walker A/P-loop; other site 1121451000772 ATP binding site [chemical binding]; other site 1121451000773 Q-loop/lid; other site 1121451000774 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 1121451000775 ABC transporter signature motif; other site 1121451000776 Walker B; other site 1121451000777 D-loop; other site 1121451000778 H-loop/switch region; other site 1121451000779 NAD(P)H:flavin oxidoreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes; Region: NADPH_oxidoreductase_1; cd02150 1121451000780 putative FMN binding site [chemical binding]; other site 1121451000781 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1121451000782 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 1121451000783 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1121451000784 Response regulator receiver domain; Region: Response_reg; pfam00072 1121451000785 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121451000786 active site 1121451000787 phosphorylation site [posttranslational modification] 1121451000788 intermolecular recognition site; other site 1121451000789 dimerization interface [polypeptide binding]; other site 1121451000790 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 1121451000791 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1121451000792 active site 1121451000793 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1121451000794 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535 1121451000795 FeS/SAM binding site; other site 1121451000796 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1121451000797 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1121451000798 S-adenosylmethionine binding site [chemical binding]; other site 1121451000799 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 1121451000800 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 1121451000801 GTPase CgtA; Reviewed; Region: obgE; PRK12299 1121451000802 GTP1/OBG; Region: GTP1_OBG; pfam01018 1121451000803 Obg GTPase; Region: Obg; cd01898 1121451000804 G1 box; other site 1121451000805 GTP/Mg2+ binding site [chemical binding]; other site 1121451000806 Switch I region; other site 1121451000807 G2 box; other site 1121451000808 G3 box; other site 1121451000809 Switch II region; other site 1121451000810 G4 box; other site 1121451000811 G5 box; other site 1121451000812 gamma-glutamyl kinase; Provisional; Region: PRK05429 1121451000813 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 1121451000814 nucleotide binding site [chemical binding]; other site 1121451000815 homotetrameric interface [polypeptide binding]; other site 1121451000816 putative phosphate binding site [ion binding]; other site 1121451000817 putative allosteric binding site; other site 1121451000818 PUA domain; Region: PUA; pfam01472 1121451000819 CRISPR/Cas system-associated protein Cas10; Region: Cas10_III; cl13853 1121451000820 Ion channel; Region: Ion_trans_2; pfam07885 1121451000821 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1121451000822 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1121451000823 putative substrate translocation pore; other site 1121451000824 PilZ domain; Region: PilZ; pfam07238 1121451000825 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 1121451000826 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 1121451000827 GPR1/FUN34/yaaH family; Region: Grp1_Fun34_YaaH; cl00685 1121451000828 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 1121451000829 homohexameric interface [polypeptide binding]; other site 1121451000830 feedback inhibition sensing region; other site 1121451000831 nucleotide binding site [chemical binding]; other site 1121451000832 N-acetyl-L-glutamate binding site [chemical binding]; other site 1121451000833 putative molybdopterin-guanine dinucleotide biosynthesis protein MobB/FeS domain-containing protein protein; Provisional; Region: PRK14494 1121451000834 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1121451000835 Putative Fe-S cluster; Region: FeS; cl17515 1121451000836 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 1121451000837 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 1121451000838 dimer interface [polypeptide binding]; other site 1121451000839 putative functional site; other site 1121451000840 putative MPT binding site; other site 1121451000841 putative molybdopterin biosynthesis protein MoeA/LysR substrate binding-domain-containing protein; Provisional; Region: PRK14498 1121451000842 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 1121451000843 dimer interface [polypeptide binding]; other site 1121451000844 putative functional site; other site 1121451000845 putative MPT binding site; other site 1121451000846 PBP superfamily domain; Region: PBP_like; pfam12727 1121451000847 formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583 1121451000848 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 1121451000849 octaheme c-type cytochrome, tetrathionate reductase family; Region: octaheme_Shew; TIGR04315 1121451000850 Cytochrome c bacterial; Region: Cytochrome_cB; pfam11783 1121451000851 hydrogenase 2 protein HybA; Provisional; Region: PRK10882 1121451000852 TAT (twin-arginine translocation) pathway signal sequence; Region: TAT_signal; pfam10518 1121451000853 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 1121451000854 dimer interface [polypeptide binding]; other site 1121451000855 Citrate synthase; Region: Citrate_synt; pfam00285 1121451000856 active site 1121451000857 citrylCoA binding site [chemical binding]; other site 1121451000858 NADH binding [chemical binding]; other site 1121451000859 cationic pore residues; other site 1121451000860 oxalacetate/citrate binding site [chemical binding]; other site 1121451000861 coenzyme A binding site [chemical binding]; other site 1121451000862 catalytic triad [active] 1121451000863 glycerol kinase; Provisional; Region: glpK; PRK00047 1121451000864 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 1121451000865 N- and C-terminal domain interface [polypeptide binding]; other site 1121451000866 active site 1121451000867 MgATP binding site [chemical binding]; other site 1121451000868 catalytic site [active] 1121451000869 metal binding site [ion binding]; metal-binding site 1121451000870 glycerol binding site [chemical binding]; other site 1121451000871 homotetramer interface [polypeptide binding]; other site 1121451000872 homodimer interface [polypeptide binding]; other site 1121451000873 FBP binding site [chemical binding]; other site 1121451000874 protein IIAGlc interface [polypeptide binding]; other site 1121451000875 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 1121451000876 amphipathic channel; other site 1121451000877 Asn-Pro-Ala signature motifs; other site 1121451000878 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 1121451000879 DNA-binding transcriptional repressor GlpR; Provisional; Region: PRK10906 1121451000880 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 1121451000881 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1121451000882 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 1121451000883 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1121451000884 ATP binding site [chemical binding]; other site 1121451000885 Mg++ binding site [ion binding]; other site 1121451000886 motif III; other site 1121451000887 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1121451000888 nucleotide binding region [chemical binding]; other site 1121451000889 ATP-binding site [chemical binding]; other site 1121451000890 RNA recognition motif in the DbpA subfamily of prokaryotic DEAD-box rRNA helicases; Region: RRM_DbpA; cd12252 1121451000891 RNA binding site [nucleotide binding]; other site 1121451000892 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 1121451000893 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 1121451000894 decaheme c-type cytochrome, DmsE family; Region: decahem_SO; TIGR03508 1121451000895 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 1121451000896 FAD binding site [chemical binding]; other site 1121451000897 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 1121451000898 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 1121451000899 THF binding site; other site 1121451000900 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 1121451000901 substrate binding site [chemical binding]; other site 1121451000902 THF binding site; other site 1121451000903 zinc-binding site [ion binding]; other site 1121451000904 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 1121451000905 cystathionine beta-lyase; Provisional; Region: PRK05967 1121451000906 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1121451000907 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1121451000908 catalytic residue [active] 1121451000909 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 1121451000910 active site 1121451000911 dimer interface [polypeptide binding]; other site 1121451000912 metal binding site [ion binding]; metal-binding site 1121451000913 3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase [Cell envelope biogenesis, outer membrane]; Region: KdsA; cl17225 1121451000914 Chorismate mutase type II; Region: CM_2; smart00830 1121451000915 flavodoxin, short chain; Region: flav_short; TIGR01753 1121451000916 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1121451000917 putative binding surface; other site 1121451000918 active site 1121451000919 ABC transporter ATPase component; Reviewed; Region: PRK11147 1121451000920 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1121451000921 Walker A/P-loop; other site 1121451000922 ATP binding site [chemical binding]; other site 1121451000923 ABC transporter signature motif; other site 1121451000924 Walker B; other site 1121451000925 D-loop; other site 1121451000926 H-loop/switch region; other site 1121451000927 ABC transporter; Region: ABC_tran_2; pfam12848 1121451000928 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1121451000929 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 1121451000930 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 1121451000931 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 1121451000932 TrkA-N domain; Region: TrkA_N; pfam02254 1121451000933 TrkA-C domain; Region: TrkA_C; pfam02080 1121451000934 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1121451000935 binding surface 1121451000936 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1121451000937 TPR motif; other site 1121451000938 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1121451000939 TPR repeat; Region: TPR_11; pfam13414 1121451000940 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1121451000941 TPR motif; other site 1121451000942 Glutamine cyclotransferase [Posttranslational modification, protein turnover, chaperones]; Region: COG3823 1121451000943 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 1121451000944 Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) [Lipid metabolism]; Region: COG1924 1121451000945 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 1121451000946 CoA enzyme activase uncharacterized domain (DUF2229); Region: DUF2229; cl17855 1121451000947 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3581 1121451000948 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 1121451000949 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1121451000950 FecR protein; Region: FecR; pfam04773 1121451000951 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 1121451000952 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 1121451000953 FecR protein; Region: FecR; pfam04773 1121451000954 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 1121451000955 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 1121451000956 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 1121451000957 Cobyrinic acid a,c-diamide synthase [Coenzyme metabolism]; Region: CobB; COG1797 1121451000958 Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132 1121451000959 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 1121451000960 catalytic triad [active] 1121451000961 Dissimilatory sulfite reductase D (DsrD); Region: DsrD; pfam08679 1121451000962 sulfite reductase, dissimilatory-type beta subunit; Region: dsrB; TIGR02066 1121451000963 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1121451000964 sulfite reductase, dissimilatory-type alpha subunit; Region: dsrA; TIGR02064 1121451000965 Flagellin N-methylase; Region: FliB; pfam03692 1121451000966 Uncharacterized conserved protein [Function unknown]; Region: COG1683 1121451000967 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 1121451000968 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 1121451000969 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 1121451000970 Na+-transporting methylmalonyl-CoA/oxaloacetate decarboxylase, beta subunit [Energy production and conversion]; Region: OadB; COG1883 1121451000971 Oxaloacetate decarboxylase, gamma chain; Region: OAD_gamma; cl01458 1121451000972 Pyruvate/oxaloacetate carboxyltransferase [Energy production and conversion]; Region: COG5016 1121451000973 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 1121451000974 active site 1121451000975 catalytic residues [active] 1121451000976 metal binding site [ion binding]; metal-binding site 1121451000977 homodimer binding site [polypeptide binding]; other site 1121451000978 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1121451000979 carboxyltransferase (CT) interaction site; other site 1121451000980 biotinylation site [posttranslational modification]; other site 1121451000981 cobalt transport protein CbiM; Validated; Region: PRK06265 1121451000982 Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891 1121451000983 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_7; cd13133 1121451000984 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 1121451000985 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1121451000986 IHF dimer interface [polypeptide binding]; other site 1121451000987 IHF - DNA interface [nucleotide binding]; other site 1121451000988 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 1121451000989 oligomerisation interface [polypeptide binding]; other site 1121451000990 mobile loop; other site 1121451000991 roof hairpin; other site 1121451000992 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 1121451000993 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 1121451000994 ring oligomerisation interface [polypeptide binding]; other site 1121451000995 ATP/Mg binding site [chemical binding]; other site 1121451000996 stacking interactions; other site 1121451000997 hinge regions; other site 1121451000998 PHP domain; Region: PHP; pfam02811 1121451000999 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase; Region: PHP_HisPPase; cd07432 1121451001000 active site 1121451001001 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1121451001002 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 1121451001003 Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; cl00789 1121451001004 Phosphoribosylformylglycinamidine (FGAM) synthase, synthetase domain [Nucleotide transport and metabolism]; Region: PurL; COG0046 1121451001005 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 1121451001006 dimerization interface [polypeptide binding]; other site 1121451001007 ATP binding site [chemical binding]; other site 1121451001008 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 1121451001009 dimerization interface [polypeptide binding]; other site 1121451001010 ATP binding site [chemical binding]; other site 1121451001011 HDOD domain; Region: HDOD; pfam08668 1121451001012 PAS domain S-box; Region: sensory_box; TIGR00229 1121451001013 PAS domain; Region: PAS; smart00091 1121451001014 putative active site [active] 1121451001015 heme pocket [chemical binding]; other site 1121451001016 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1121451001017 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1121451001018 metal binding site [ion binding]; metal-binding site 1121451001019 active site 1121451001020 I-site; other site 1121451001021 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1121451001022 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1121451001023 substrate binding pocket [chemical binding]; other site 1121451001024 chain length determination region; other site 1121451001025 substrate-Mg2+ binding site; other site 1121451001026 catalytic residues [active] 1121451001027 aspartate-rich region 1; other site 1121451001028 active site lid residues [active] 1121451001029 aspartate-rich region 2; other site 1121451001030 futalosine nucleosidase; Region: fut_nucase; TIGR03664 1121451001031 Vi polysaccharide biosynthesis protein TviB; Provisional; Region: PRK15182 1121451001032 TrkA-N domain; Region: TrkA_N; pfam02254 1121451001033 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1121451001034 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 1121451001035 Uncharacterized protein conserved in bacteria (DUF2065); Region: DUF2065; pfam09838 1121451001036 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 1121451001037 ubiquinone/menaquinone biosynthesis methyltransferase; Reviewed; Region: ubiE; PRK00216 1121451001038 S-adenosylmethionine binding site [chemical binding]; other site 1121451001039 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168 1121451001040 heme-binding residues [chemical binding]; other site 1121451001041 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 1121451001042 active site 1121451001043 SAM binding site [chemical binding]; other site 1121451001044 homodimer interface [polypeptide binding]; other site 1121451001045 cobalamin biosynthesis protein CbiG; Validated; Region: PRK05788 1121451001046 Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760 1121451001047 Cobalamin biosynthesis central region; Region: CbiG_mid; pfam11761 1121451001048 Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890 1121451001049 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 1121451001050 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1121451001051 inhibitor-cofactor binding pocket; inhibition site 1121451001052 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1121451001053 catalytic residue [active] 1121451001054 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1121451001055 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 1121451001056 cytochrome c-type protein NapC; Provisional; Region: PRK10617; cl17554 1121451001057 NapC/NirT cytochrome c family, N-terminal region; Region: Cytochrom_NNT; pfam03264 1121451001058 Seven times multi-haem cytochrome CxxCH; Region: Multi-haem_cyto; pfam13447 1121451001059 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 1121451001060 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1121451001061 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 1121451001062 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 1121451001063 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 1121451001064 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1121451001065 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121451001066 active site 1121451001067 phosphorylation site [posttranslational modification] 1121451001068 intermolecular recognition site; other site 1121451001069 dimerization interface [polypeptide binding]; other site 1121451001070 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06710 1121451001071 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 1121451001072 acyl-activating enzyme (AAE) consensus motif; other site 1121451001073 putative AMP binding site [chemical binding]; other site 1121451001074 putative active site [active] 1121451001075 putative CoA binding site [chemical binding]; other site 1121451001076 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1121451001077 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1121451001078 dimer interface [polypeptide binding]; other site 1121451001079 putative CheW interface [polypeptide binding]; other site 1121451001080 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 1121451001081 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 1121451001082 TPP-binding site; other site 1121451001083 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1121451001084 PYR/PP interface [polypeptide binding]; other site 1121451001085 dimer interface [polypeptide binding]; other site 1121451001086 TPP binding site [chemical binding]; other site 1121451001087 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1121451001088 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1121451001089 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1121451001090 substrate binding pocket [chemical binding]; other site 1121451001091 chain length determination region; other site 1121451001092 substrate-Mg2+ binding site; other site 1121451001093 catalytic residues [active] 1121451001094 aspartate-rich region 1; other site 1121451001095 active site lid residues [active] 1121451001096 aspartate-rich region 2; other site 1121451001097 Exonuclease VII small subunit; Region: Exonuc_VII_S; cl00750 1121451001098 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1121451001099 Peptidase family M23; Region: Peptidase_M23; pfam01551 1121451001100 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 1121451001101 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 1121451001102 generic binding surface II; other site 1121451001103 generic binding surface I; other site 1121451001104 prolyl-tRNA synthetase; Provisional; Region: PRK09194 1121451001105 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 1121451001106 dimer interface [polypeptide binding]; other site 1121451001107 motif 1; other site 1121451001108 active site 1121451001109 motif 2; other site 1121451001110 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 1121451001111 putative deacylase active site [active] 1121451001112 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1121451001113 active site 1121451001114 motif 3; other site 1121451001115 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 1121451001116 anticodon binding site; other site 1121451001117 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 1121451001118 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 1121451001119 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 1121451001120 Uracil-DNA glycosylases (UDG) and related enzymes; Region: UDG_like; cl00483 1121451001121 ligand binding site [chemical binding]; other site 1121451001122 active site 1121451001123 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 1121451001124 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 1121451001125 Active Sites [active] 1121451001126 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 1121451001127 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 1121451001128 dimer interface [polypeptide binding]; other site 1121451001129 PYR/PP interface [polypeptide binding]; other site 1121451001130 TPP binding site [chemical binding]; other site 1121451001131 substrate binding site [chemical binding]; other site 1121451001132 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 1121451001133 Domain of unknown function; Region: EKR; pfam10371 1121451001134 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1121451001135 Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377 1121451001136 TPP-binding site [chemical binding]; other site 1121451001137 dimer interface [polypeptide binding]; other site 1121451001138 phosphate acetyltransferase; Reviewed; Region: PRK05632 1121451001139 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1121451001140 DRTGG domain; Region: DRTGG; pfam07085 1121451001141 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 1121451001142 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 1121451001143 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 1121451001144 transmembrane helices; other site 1121451001145 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 1121451001146 Malic enzyme, N-terminal domain; Region: malic; pfam00390 1121451001147 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 1121451001148 putative NAD(P) binding site [chemical binding]; other site 1121451001149 Fumarase C-terminus; Region: Fumerase_C; cl00795 1121451001150 fumarate hydratase; Provisional; Region: PRK06246 1121451001151 fumarate reductase iron-sulfur subunit; Provisional; Region: frdB; PRK13552 1121451001152 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 1121451001153 fumarate reductase flavoprotein subunit; Provisional; Region: PRK08626 1121451001154 L-aspartate oxidase; Provisional; Region: PRK06175 1121451001155 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1121451001156 Quinol:fumarate reductase (QFR) Type B subfamily, transmembrane subunit; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinone...; Region: QFR_TypeB_TM; cd00581 1121451001157 Iron-sulfur protein interface; other site 1121451001158 proximal heme binding site [chemical binding]; other site 1121451001159 distal heme binding site [chemical binding]; other site 1121451001160 dimer interface [polypeptide binding]; other site 1121451001161 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1121451001162 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1121451001163 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1121451001164 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1121451001165 putative substrate translocation pore; other site 1121451001166 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 1121451001167 ApbE family; Region: ApbE; pfam02424 1121451001168 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 1121451001169 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 1121451001170 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1121451001171 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1121451001172 putative active site [active] 1121451001173 heme pocket [chemical binding]; other site 1121451001174 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1121451001175 dimer interface [polypeptide binding]; other site 1121451001176 phosphorylation site [posttranslational modification] 1121451001177 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1121451001178 ATP binding site [chemical binding]; other site 1121451001179 Mg2+ binding site [ion binding]; other site 1121451001180 G-X-G motif; other site 1121451001181 Bacterial Ig-like domain; Region: Big_5; pfam13205 1121451001182 Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373 1121451001183 MG2 domain; Region: A2M_N; pfam01835 1121451001184 Alpha-2-macroglobulin family; Region: A2M; pfam00207 1121451001185 Proteins similar to alpha2-macroglobulin (alpha (2)-M). Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of...; Region: A2M_like; cd02891 1121451001186 surface patch; other site 1121451001187 thioester region; other site 1121451001188 penicillin-binding protein 1C; Region: PBP_1c; TIGR02073 1121451001189 Transglycosylase; Region: Transgly; pfam00912 1121451001190 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1121451001191 Penicillin-Binding Protein C-terminus Family; Region: BiPBP_C; pfam06832 1121451001192 Immunoglobulin domain; Region: Ig; cl11960 1121451001193 benzoyl-CoA reductase, subunit C; Region: benz_CoA_red_C; TIGR02263 1121451001194 2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050 1121451001195 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 1121451001196 30S ribosomal protein S1; Provisional; Region: rpsA; PRK13806 1121451001197 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 1121451001198 RNA binding site [nucleotide binding]; other site 1121451001199 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 1121451001200 RNA binding site [nucleotide binding]; other site 1121451001201 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1121451001202 RNA binding site [nucleotide binding]; other site 1121451001203 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1121451001204 RNA binding site [nucleotide binding]; other site 1121451001205 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cd00164 1121451001206 RNA binding site [nucleotide binding]; other site 1121451001207 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1121451001208 FxsA cytoplasmic membrane protein; Region: FxsA; pfam04186 1121451001209 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 1121451001210 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 1121451001211 Sporulation related domain; Region: SPOR; pfam05036 1121451001212 Predicted RNA-binding protein, contains TRAM domain [General function prediction only]; Region: COG3269 1121451001213 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 1121451001214 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1121451001215 S-adenosylmethionine binding site [chemical binding]; other site 1121451001216 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1121451001217 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1121451001218 adenylate cyclase; Provisional; Region: cyaA; PRK09450 1121451001219 Adenylate cyclase NT domain; Region: Adenyl_cycl_N; pfam12633 1121451001220 Adenylate cyclase, class-I; Region: Adenylate_cycl; pfam01295 1121451001221 HD domain; Region: HD_3; pfam13023 1121451001222 CBS domain; Region: CBS; pfam00571 1121451001223 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1121451001224 Zn2+ binding site [ion binding]; other site 1121451001225 Mg2+ binding site [ion binding]; other site 1121451001226 cell division protein MraZ; Reviewed; Region: PRK00326 1121451001227 MraZ protein; Region: MraZ; pfam02381 1121451001228 MraZ protein; Region: MraZ; pfam02381 1121451001229 MraW methylase family; Region: Methyltransf_5; cl17771 1121451001230 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 1121451001231 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1121451001232 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1121451001233 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1121451001234 PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576 1121451001235 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1121451001236 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 1121451001237 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1121451001238 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1121451001239 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1121451001240 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Region: murF; TIGR01143 1121451001241 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1121451001242 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1121451001243 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 1121451001244 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 1121451001245 Mg++ binding site [ion binding]; other site 1121451001246 putative catalytic motif [active] 1121451001247 putative substrate binding site [chemical binding]; other site 1121451001248 UDP-N-acetylmuramoylalanine-D-glutamate ligase [Cell envelope biogenesis, outer membrane]; Region: MurD; COG0771 1121451001249 Alanine dehydrogenase/PNT, C-terminal domain; Region: AlaDh_PNT_C; smart01002 1121451001250 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1121451001251 cell division protein FtsW; Region: ftsW; TIGR02614 1121451001252 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 1121451001253 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 1121451001254 active site 1121451001255 homodimer interface [polypeptide binding]; other site 1121451001256 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 1121451001257 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1121451001258 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1121451001259 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1121451001260 UDP-N-acetylmuramate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: MurB; COG0812 1121451001261 FAD binding domain; Region: FAD_binding_4; pfam01565 1121451001262 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 1121451001263 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 1121451001264 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 1121451001265 cell division protein FtsA; Region: ftsA; TIGR01174 1121451001266 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1121451001267 nucleotide binding site [chemical binding]; other site 1121451001268 SHS2 domain inserted in FTSA; Region: SHS2_FTSA; pfam02491 1121451001269 Cell division protein FtsA; Region: FtsA; pfam14450 1121451001270 cell division protein FtsZ; Validated; Region: PRK09330 1121451001271 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 1121451001272 nucleotide binding site [chemical binding]; other site 1121451001273 SulA interaction site; other site 1121451001274 radical SAM family uncharacterized protein; Region: rSAM_fuse_unch; TIGR03960 1121451001275 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1121451001276 FeS/SAM binding site; other site 1121451001277 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 1121451001278 dimer interface [polypeptide binding]; other site 1121451001279 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 1121451001280 dimer interface [polypeptide binding]; other site 1121451001281 Domain of unknown function (DUF4405); Region: DUF4405; pfam14358 1121451001282 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1121451001283 PAS domain; Region: PAS; smart00091 1121451001284 putative active site [active] 1121451001285 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1121451001286 dimer interface [polypeptide binding]; other site 1121451001287 phosphorylation site [posttranslational modification] 1121451001288 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1121451001289 ATP binding site [chemical binding]; other site 1121451001290 Mg2+ binding site [ion binding]; other site 1121451001291 G-X-G motif; other site 1121451001292 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 1121451001293 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121451001294 active site 1121451001295 phosphorylation site [posttranslational modification] 1121451001296 intermolecular recognition site; other site 1121451001297 dimerization interface [polypeptide binding]; other site 1121451001298 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1121451001299 Walker A motif; other site 1121451001300 ATP binding site [chemical binding]; other site 1121451001301 Walker B motif; other site 1121451001302 arginine finger; other site 1121451001303 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1121451001304 ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175 1121451001305 ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294 1121451001306 Walker A/P-loop; other site 1121451001307 ATP binding site [chemical binding]; other site 1121451001308 Q-loop/lid; other site 1121451001309 ABC transporter signature motif; other site 1121451001310 Walker B; other site 1121451001311 D-loop; other site 1121451001312 H-loop/switch region; other site 1121451001313 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 1121451001314 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1121451001315 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1121451001316 dimer interface [polypeptide binding]; other site 1121451001317 conserved gate region; other site 1121451001318 putative PBP binding loops; other site 1121451001319 ABC-ATPase subunit interface; other site 1121451001320 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 1121451001321 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 1121451001322 HDOD domain; Region: HDOD; pfam08668 1121451001323 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1121451001324 Zn2+ binding site [ion binding]; other site 1121451001325 Mg2+ binding site [ion binding]; other site 1121451001326 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 1121451001327 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 1121451001328 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1121451001329 HIGH motif; other site 1121451001330 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1121451001331 active site 1121451001332 KMSKS motif; other site 1121451001333 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1121451001334 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1121451001335 substrate binding pocket [chemical binding]; other site 1121451001336 membrane-bound complex binding site; other site 1121451001337 hinge residues; other site 1121451001338 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 1121451001339 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 1121451001340 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 1121451001341 TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358 1121451001342 TRAP transporter, 4TM/12TM fusion protein; Region: TRAP_fused; TIGR02123 1121451001343 DctM-like transporters; Region: DctM; pfam06808 1121451001344 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 1121451001345 Uncharacterized ACR, COG1399; Region: DUF177; pfam02620 1121451001346 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 1121451001347 putative phosphate acyltransferase; Provisional; Region: PRK05331 1121451001348 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 1121451001349 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 1121451001350 dimer interface [polypeptide binding]; other site 1121451001351 active site 1121451001352 CoA binding pocket [chemical binding]; other site 1121451001353 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 1121451001354 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 1121451001355 NAD(P) binding site [chemical binding]; other site 1121451001356 homotetramer interface [polypeptide binding]; other site 1121451001357 homodimer interface [polypeptide binding]; other site 1121451001358 active site 1121451001359 acyl carrier protein; Provisional; Region: acpP; PRK00982 1121451001360 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 1121451001361 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1121451001362 dimer interface [polypeptide binding]; other site 1121451001363 active site 1121451001364 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 1121451001365 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 1121451001366 dimer interface [polypeptide binding]; other site 1121451001367 active site 1121451001368 glycine-pyridoxal phosphate binding site [chemical binding]; other site 1121451001369 folate binding site [chemical binding]; other site 1121451001370 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 1121451001371 catalytic motif [active] 1121451001372 Zn binding site [ion binding]; other site 1121451001373 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 1121451001374 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 1121451001375 catalytic motif [active] 1121451001376 Zn binding site [ion binding]; other site 1121451001377 RibD C-terminal domain; Region: RibD_C; cl17279 1121451001378 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 1121451001379 Lumazine binding domain; Region: Lum_binding; pfam00677 1121451001380 Lumazine binding domain; Region: Lum_binding; pfam00677 1121451001381 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 1121451001382 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 1121451001383 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 1121451001384 dimerization interface [polypeptide binding]; other site 1121451001385 active site 1121451001386 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 1121451001387 homopentamer interface [polypeptide binding]; other site 1121451001388 active site 1121451001389 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 1121451001390 putative RNA binding site [nucleotide binding]; other site 1121451001391 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 1121451001392 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 1121451001393 HIGH motif; other site 1121451001394 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1121451001395 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 1121451001396 active site 1121451001397 KMSKS motif; other site 1121451001398 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 1121451001399 tRNA binding surface [nucleotide binding]; other site 1121451001400 Lipopolysaccharide-assembly; Region: LptE; cl01125 1121451001401 DNA polymerase III, delta subunit [DNA replication, recombination, and repair]; Region: HolA; COG1466 1121451001402 hypothetical protein; Reviewed; Region: PRK00024 1121451001403 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 1121451001404 MPN+ (JAMM) motif; other site 1121451001405 Zinc-binding site [ion binding]; other site 1121451001406 Acylphosphatase; Region: Acylphosphatase; pfam00708 1121451001407 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 1121451001408 Found in ATP-dependent protease La (LON); Region: LON; smart00464 1121451001409 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1121451001410 Walker A motif; other site 1121451001411 ATP binding site [chemical binding]; other site 1121451001412 Walker B motif; other site 1121451001413 arginine finger; other site 1121451001414 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 1121451001415 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; pfam09723 1121451001416 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 1121451001417 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 1121451001418 domain interfaces; other site 1121451001419 active site 1121451001420 Pathogenicity locus; Region: Cdd1; pfam11731 1121451001421 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195 1121451001422 dimerization interface [polypeptide binding]; other site 1121451001423 putative ATP binding site [chemical binding]; other site 1121451001424 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 1121451001425 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 1121451001426 putative dimer interface [polypeptide binding]; other site 1121451001427 active site pocket [active] 1121451001428 putative cataytic base [active] 1121451001429 shikimate kinase; Reviewed; Region: aroK; PRK00131 1121451001430 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 1121451001431 ADP binding site [chemical binding]; other site 1121451001432 magnesium binding site [ion binding]; other site 1121451001433 putative shikimate binding site; other site 1121451001434 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 1121451001435 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1121451001436 active site 1121451001437 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1121451001438 metal-binding site [ion binding] 1121451001439 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1121451001440 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1121451001441 metal-binding site [ion binding] 1121451001442 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1121451001443 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1121451001444 Arginase-like amidino hydrolase family; Region: Arginase-like_1; cd09999 1121451001445 active site 1121451001446 Mn binding site [ion binding]; other site 1121451001447 TPR repeat; Region: TPR_11; pfam13414 1121451001448 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1121451001449 binding surface 1121451001450 TPR motif; other site 1121451001451 TPR repeat; Region: TPR_11; pfam13414 1121451001452 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1121451001453 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1121451001454 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 1121451001455 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1121451001456 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1121451001457 binding surface 1121451001458 TPR motif; other site 1121451001459 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1121451001460 ABC-type amino acid transport/signal transduction systems, periplasmic component/domain [Amino acid transport and metabolism / Signal transduction mechanisms]; Region: HisJ; COG0834 1121451001461 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1121451001462 substrate binding pocket [chemical binding]; other site 1121451001463 membrane-bound complex binding site; other site 1121451001464 hinge residues; other site 1121451001465 FOG: CBS domain [General function prediction only]; Region: COG0517 1121451001466 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 1121451001467 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 1121451001468 Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375 1121451001469 Hydrogenase expression/synthesis hypA family; Region: HypA; pfam01155 1121451001470 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1121451001471 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1121451001472 PAS domain; Region: PAS_9; pfam13426 1121451001473 putative active site [active] 1121451001474 heme pocket [chemical binding]; other site 1121451001475 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 1121451001476 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1121451001477 Walker A motif; other site 1121451001478 ATP binding site [chemical binding]; other site 1121451001479 Walker B motif; other site 1121451001480 arginine finger; other site 1121451001481 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 1121451001482 Dinitrogenase iron-molybdenum cofactor; Region: Nitro_FeMo-Co; pfam02579 1121451001483 This uncharacterized conserved protein belongs to a family of iron-molybdenum cluster-binding proteins that includes NifX, NifB, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of...; Region: MTH1175; cd00851 1121451001484 CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656 1121451001485 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 1121451001486 This uncharacterized conserved protein belongs to a family of iron-molybdenum cluster-binding proteins that includes NifX, NifB, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of...; Region: MTH1175; cd00851 1121451001487 Integrase core domain; Region: rve; pfam00665 1121451001488 Integrase core domain; Region: rve_3; pfam13683 1121451001489 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1121451001490 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1121451001491 S-adenosylmethionine binding site [chemical binding]; other site 1121451001492 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1121451001493 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1121451001494 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1121451001495 Radical SAM superfamily; Region: Radical_SAM; pfam04055 1121451001496 FeS/SAM binding site; other site 1121451001497 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 1121451001498 Methyltransferase domain; Region: Methyltransf_24; pfam13578 1121451001499 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 1121451001500 active site 1121451001501 asparagine synthase (glutamine-hydrolyzing); Region: asn_synth_AEB; TIGR01536 1121451001502 dimer interface [polypeptide binding]; other site 1121451001503 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 1121451001504 Ligand Binding Site [chemical binding]; other site 1121451001505 Molecular Tunnel; other site 1121451001506 Protein of unknown function (DUF616); Region: DUF616; pfam04765 1121451001507 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1121451001508 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1121451001509 S-adenosylmethionine binding site [chemical binding]; other site 1121451001510 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1121451001511 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1121451001512 active site 1121451001513 Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632 1121451001514 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1121451001515 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1121451001516 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1121451001517 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1121451001518 active site 1121451001519 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 1121451001520 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 1121451001521 Transposase; Region: HTH_Tnp_1; pfam01527 1121451001522 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1121451001523 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 1121451001524 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 1121451001525 putative dimer interface [polypeptide binding]; other site 1121451001526 Transposase; Region: HTH_Tnp_1; cl17663 1121451001527 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; Product type h : extrachromosomal origin 1121451001528 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; Product type h : extrachromosomal origin 1121451001529 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1121451001530 DNA binding site [nucleotide binding] 1121451001531 active site 1121451001532 Int/Topo IB signature motif; other site 1121451001533 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 1121451001534 salt bridge; other site 1121451001535 non-specific DNA binding site [nucleotide binding]; other site 1121451001536 sequence-specific DNA binding site [nucleotide binding]; other site 1121451001537 HipA N-terminal domain; Region: Couple_hipA; cl11853 1121451001538 HipA-like N-terminal domain; Region: HipA_N; pfam07805 1121451001539 HipA-like C-terminal domain; Region: HipA_C; pfam07804 1121451001540 Fic family protein [Function unknown]; Region: COG3177 1121451001541 Fic/DOC family; Region: Fic; pfam02661 1121451001542 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1121451001543 Transposase; Region: HTH_Tnp_1; cl17663 1121451001544 Integrase core domain; Region: rve_3; pfam13683 1121451001545 Protein of unknown function (DUF554); Region: DUF554; pfam04474 1121451001546 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 1121451001547 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1121451001548 dimerization interface [polypeptide binding]; other site 1121451001549 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 1121451001550 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 1121451001551 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 1121451001552 ornithine--oxo-acid transaminase; Reviewed; Region: rocD; PRK00854 1121451001553 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1121451001554 inhibitor-cofactor binding pocket; inhibition site 1121451001555 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1121451001556 catalytic residue [active] 1121451001557 Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292 1121451001558 Two component regulator propeller; Region: Reg_prop; pfam07494 1121451001559 Two component regulator propeller; Region: Reg_prop; pfam07494 1121451001560 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 1121451001561 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1121451001562 dimer interface [polypeptide binding]; other site 1121451001563 phosphorylation site [posttranslational modification] 1121451001564 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1121451001565 ATP binding site [chemical binding]; other site 1121451001566 Mg2+ binding site [ion binding]; other site 1121451001567 G-X-G motif; other site 1121451001568 Response regulator receiver domain; Region: Response_reg; pfam00072 1121451001569 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121451001570 active site 1121451001571 phosphorylation site [posttranslational modification] 1121451001572 intermolecular recognition site; other site 1121451001573 dimerization interface [polypeptide binding]; other site 1121451001574 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1121451001575 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1121451001576 putative active site [active] 1121451001577 heme pocket [chemical binding]; other site 1121451001578 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1121451001579 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1121451001580 putative active site [active] 1121451001581 heme pocket [chemical binding]; other site 1121451001582 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1121451001583 dimer interface [polypeptide binding]; other site 1121451001584 phosphorylation site [posttranslational modification] 1121451001585 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1121451001586 ATP binding site [chemical binding]; other site 1121451001587 Mg2+ binding site [ion binding]; other site 1121451001588 G-X-G motif; other site 1121451001589 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1121451001590 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121451001591 active site 1121451001592 phosphorylation site [posttranslational modification] 1121451001593 intermolecular recognition site; other site 1121451001594 dimerization interface [polypeptide binding]; other site 1121451001595 Putative pyruvate format-lyase activating enzyme (DUF1786); Region: DUF1786; cl01638 1121451001596 HEAT repeats; Region: HEAT_2; pfam13646 1121451001597 HEAT repeats; Region: HEAT_2; pfam13646 1121451001598 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1121451001599 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121451001600 active site 1121451001601 phosphorylation site [posttranslational modification] 1121451001602 intermolecular recognition site; other site 1121451001603 dimerization interface [polypeptide binding]; other site 1121451001604 Predicted inhibitor of MCP methylation, homolog of CheC [Cell motility and secretion]; Region: COG1406 1121451001605 Chemotaxis phosphatase CheX; Region: CheX; pfam13690 1121451001606 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 1121451001607 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 1121451001608 Cl- selectivity filter; other site 1121451001609 Cl- binding residues [ion binding]; other site 1121451001610 pore gating glutamate residue; other site 1121451001611 dimer interface [polypeptide binding]; other site 1121451001612 FOG: CBS domain [General function prediction only]; Region: COG0517 1121451001613 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 1121451001614 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1121451001615 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1121451001616 substrate binding pocket [chemical binding]; other site 1121451001617 membrane-bound complex binding site; other site 1121451001618 hinge residues; other site 1121451001619 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1121451001620 Zn2+ binding site [ion binding]; other site 1121451001621 Mg2+ binding site [ion binding]; other site 1121451001622 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 1121451001623 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 1121451001624 glutaminase active site [active] 1121451001625 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 1121451001626 dimer interface [polypeptide binding]; other site 1121451001627 active site 1121451001628 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 1121451001629 dimer interface [polypeptide binding]; other site 1121451001630 active site 1121451001631 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 1121451001632 active site 1121451001633 dimerization interface [polypeptide binding]; other site 1121451001634 PAS fold; Region: PAS_4; pfam08448 1121451001635 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1121451001636 dimer interface [polypeptide binding]; other site 1121451001637 phosphorylation site [posttranslational modification] 1121451001638 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1121451001639 ATP binding site [chemical binding]; other site 1121451001640 Mg2+ binding site [ion binding]; other site 1121451001641 G-X-G motif; other site 1121451001642 ribosomal protein S12 methylthiotransferase RimO; Region: TIGR01125 1121451001643 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 1121451001644 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377 1121451001645 FeS/SAM binding site; other site 1121451001646 Peptidase family C25; Region: Peptidase_C25; pfam01364 1121451001647 active site 1121451001648 Sporulation related domain; Region: SPOR; pfam05036 1121451001649 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 1121451001650 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 1121451001651 putative active site [active] 1121451001652 Domain of unknown function (DUF202); Region: DUF202; cl09954 1121451001653 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 1121451001654 active site 1121451001655 UDP-N-acetylglucosamine 2-epimerase; Region: Epimerase_2; pfam02350 1121451001656 homodimer interface [polypeptide binding]; other site 1121451001657 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1121451001658 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1121451001659 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1121451001660 active site 1121451001661 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1121451001662 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1121451001663 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 1121451001664 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 1121451001665 Winged helix-turn helix; Region: HTH_29; pfam13551 1121451001666 Helix-turn-helix domain; Region: HTH_28; pfam13518 1121451001667 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 1121451001668 Integrase core domain; Region: rve; pfam00665 1121451001669 Integrase core domain; Region: rve_3; pfam13683 1121451001670 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 1121451001671 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 1121451001672 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 1121451001673 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 1121451001674 transmembrane helices; other site 1121451001675 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 1121451001676 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 1121451001677 active site 1121451001678 PHP Thumb interface [polypeptide binding]; other site 1121451001679 metal binding site [ion binding]; metal-binding site 1121451001680 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 1121451001681 generic binding surface II; other site 1121451001682 generic binding surface I; other site 1121451001683 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 1121451001684 active site 1121451001685 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 1121451001686 putative active site [active] 1121451001687 dimerization interface [polypeptide binding]; other site 1121451001688 putative tRNAtyr binding site [nucleotide binding]; other site 1121451001689 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 1121451001690 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 1121451001691 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1121451001692 anti sigma factor interaction site; other site 1121451001693 regulatory phosphorylation site [posttranslational modification]; other site 1121451001694 Protein of unknown function (DUF342); Region: DUF342; pfam03961 1121451001695 Protein of unknown function (DUF2869); Region: DUF2869; pfam11068 1121451001696 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 1121451001697 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 1121451001698 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 1121451001699 flagellar motor protein MotS; Reviewed; Region: PRK06925 1121451001700 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1121451001701 ligand binding site [chemical binding]; other site 1121451001702 DUF based on E. rectale Gene description (DUF3880); Region: DUF3880; pfam12996 1121451001703 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 1121451001704 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; pfam09723 1121451001705 CHASE4 domain; Region: CHASE4; pfam05228 1121451001706 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1121451001707 dimer interface [polypeptide binding]; other site 1121451001708 phosphorylation site [posttranslational modification] 1121451001709 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1121451001710 ATP binding site [chemical binding]; other site 1121451001711 Mg2+ binding site [ion binding]; other site 1121451001712 G-X-G motif; other site 1121451001713 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 1121451001714 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1121451001715 active site 1121451001716 HIGH motif; other site 1121451001717 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1121451001718 KMSKS motif; other site 1121451001719 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 1121451001720 tRNA binding surface [nucleotide binding]; other site 1121451001721 anticodon binding site; other site 1121451001722 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 1121451001723 bifunctional 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase/2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase protein; Provisional; Region: ispDF; PRK09382 1121451001724 substrate binding site; other site 1121451001725 dimer interface; other site 1121451001726 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 1121451001727 homotrimer interaction site [polypeptide binding]; other site 1121451001728 zinc binding site [ion binding]; other site 1121451001729 CDP-binding sites; other site 1121451001730 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 1121451001731 Putative zinc ribbon domain; Region: DUF164; pfam02591 1121451001732 Uncharacterized conserved protein [Function unknown]; Region: COG0327 1121451001733 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 1121451001734 ADP-heptose synthase, bifunctional sugar kinase/adenylyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaE; COG2870 1121451001735 rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199 1121451001736 active site 1121451001737 HIGH motif; other site 1121451001738 nucleotide binding site [chemical binding]; other site 1121451001739 Domain of unknown function (DUF955); Region: DUF955; pfam06114 1121451001740 Flagellin N-methylase; Region: FliB; pfam03692 1121451001741 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 1121451001742 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1121451001743 active site 1121451001744 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 1121451001745 putative active site [active] 1121451001746 putative metal binding site [ion binding]; other site 1121451001747 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 1121451001748 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1121451001749 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1121451001750 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1121451001751 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1121451001752 dimer interface [polypeptide binding]; other site 1121451001753 conserved gate region; other site 1121451001754 putative PBP binding loops; other site 1121451001755 ABC-ATPase subunit interface; other site 1121451001756 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1121451001757 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1121451001758 dimer interface [polypeptide binding]; other site 1121451001759 conserved gate region; other site 1121451001760 putative PBP binding loops; other site 1121451001761 ABC-ATPase subunit interface; other site 1121451001762 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1121451001763 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1121451001764 substrate binding pocket [chemical binding]; other site 1121451001765 membrane-bound complex binding site; other site 1121451001766 hinge residues; other site 1121451001767 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1121451001768 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1121451001769 Walker A/P-loop; other site 1121451001770 ATP binding site [chemical binding]; other site 1121451001771 Q-loop/lid; other site 1121451001772 ABC transporter signature motif; other site 1121451001773 Walker B; other site 1121451001774 D-loop; other site 1121451001775 H-loop/switch region; other site 1121451001776 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 1121451001777 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121451001778 active site 1121451001779 phosphorylation site [posttranslational modification] 1121451001780 intermolecular recognition site; other site 1121451001781 dimerization interface [polypeptide binding]; other site 1121451001782 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1121451001783 Walker A motif; other site 1121451001784 ATP binding site [chemical binding]; other site 1121451001785 Walker B motif; other site 1121451001786 arginine finger; other site 1121451001787 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1121451001788 seryl-tRNA synthetase; Provisional; Region: PRK05431 1121451001789 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 1121451001790 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 1121451001791 dimer interface [polypeptide binding]; other site 1121451001792 active site 1121451001793 motif 1; other site 1121451001794 motif 2; other site 1121451001795 motif 3; other site 1121451001796 Competence-damaged protein; Region: CinA; pfam02464 1121451001797 Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966 1121451001798 2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258 1121451001799 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 1121451001800 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 1121451001801 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 1121451001802 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1121451001803 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1121451001804 protein binding site [polypeptide binding]; other site 1121451001805 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1121451001806 heat shock protein HtpX; Provisional; Region: PRK03982 1121451001807 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 1121451001808 PAS domain S-box; Region: sensory_box; TIGR00229 1121451001809 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1121451001810 putative active site [active] 1121451001811 heme pocket [chemical binding]; other site 1121451001812 PAS fold; Region: PAS_4; pfam08448 1121451001813 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1121451001814 putative active site [active] 1121451001815 heme pocket [chemical binding]; other site 1121451001816 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1121451001817 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 1121451001818 dimer interface [polypeptide binding]; other site 1121451001819 phosphorylation site [posttranslational modification] 1121451001820 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1121451001821 ATP binding site [chemical binding]; other site 1121451001822 Mg2+ binding site [ion binding]; other site 1121451001823 G-X-G motif; other site 1121451001824 FecR protein; Region: FecR; pfam04773 1121451001825 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 1121451001826 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1121451001827 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121451001828 active site 1121451001829 dimerization interface [polypeptide binding]; other site 1121451001830 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1121451001831 binding surface 1121451001832 TPR motif; other site 1121451001833 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1121451001834 TPR motif; other site 1121451001835 TPR repeat; Region: TPR_11; pfam13414 1121451001836 binding surface 1121451001837 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1121451001838 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 1121451001839 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 1121451001840 tandem repeat interface [polypeptide binding]; other site 1121451001841 oligomer interface [polypeptide binding]; other site 1121451001842 active site residues [active] 1121451001843 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 1121451001844 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 1121451001845 RNA binding site [nucleotide binding]; other site 1121451001846 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 1121451001847 RNA binding site [nucleotide binding]; other site 1121451001848 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1121451001849 RNA binding site [nucleotide binding]; other site 1121451001850 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1121451001851 RNA binding site [nucleotide binding]; other site 1121451001852 S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec5; cd05690 1121451001853 RNA binding site [nucleotide binding]; other site 1121451001854 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1121451001855 RNA binding site [nucleotide binding]; other site 1121451001856 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 1121451001857 PhoU domain; Region: PhoU; pfam01895 1121451001858 PhoU domain; Region: PhoU; pfam01895 1121451001859 phosphate transporter ATP-binding protein; Provisional; Region: PRK14242 1121451001860 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 1121451001861 Walker A/P-loop; other site 1121451001862 ATP binding site [chemical binding]; other site 1121451001863 Q-loop/lid; other site 1121451001864 ABC transporter signature motif; other site 1121451001865 Walker B; other site 1121451001866 D-loop; other site 1121451001867 H-loop/switch region; other site 1121451001868 AMIN domain; Region: AMIN; pfam11741 1121451001869 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 1121451001870 homodimer interface [polypeptide binding]; other site 1121451001871 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 1121451001872 active site pocket [active] 1121451001873 ROS/MUCR transcriptional regulator protein; Region: ROS_MUCR; pfam05443 1121451001874 flagellar motor protein MotS; Reviewed; Region: PRK06925 1121451001875 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 1121451001876 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1121451001877 ligand binding site [chemical binding]; other site 1121451001878 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1121451001879 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121451001880 active site 1121451001881 phosphorylation site [posttranslational modification] 1121451001882 intermolecular recognition site; other site 1121451001883 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 1121451001884 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 1121451001885 hexamer interface [polypeptide binding]; other site 1121451001886 ligand binding site [chemical binding]; other site 1121451001887 putative active site [active] 1121451001888 NAD(P) binding site [chemical binding]; other site 1121451001889 Response regulator receiver domain; Region: Response_reg; pfam00072 1121451001890 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121451001891 active site 1121451001892 phosphorylation site [posttranslational modification] 1121451001893 intermolecular recognition site; other site 1121451001894 dimerization interface [polypeptide binding]; other site 1121451001895 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 1121451001896 Protein of unknwon function (DUF2893); Region: DUF2893; pfam11459 1121451001897 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843 1121451001898 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 1121451001899 dimer interface [polypeptide binding]; other site 1121451001900 catalytic triad [active] 1121451001901 peroxidatic and resolving cysteines [active] 1121451001902 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 1121451001903 active site 1121451001904 catalytic residues [active] 1121451001905 DNA binding site [nucleotide binding] 1121451001906 Int/Topo IB signature motif; other site 1121451001907 TOBE domain; Region: TOBE; cl01440 1121451001908 TOBE domain; Region: TOBE; cl01440 1121451001909 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1121451001910 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1121451001911 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 1121451001912 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1121451001913 dimer interface [polypeptide binding]; other site 1121451001914 conserved gate region; other site 1121451001915 putative PBP binding loops; other site 1121451001916 ABC-ATPase subunit interface; other site 1121451001917 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4136 1121451001918 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1121451001919 Walker A/P-loop; other site 1121451001920 ATP binding site [chemical binding]; other site 1121451001921 Q-loop/lid; other site 1121451001922 ABC transporter signature motif; other site 1121451001923 Walker B; other site 1121451001924 D-loop; other site 1121451001925 H-loop/switch region; other site 1121451001926 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1121451001927 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1121451001928 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1121451001929 dimer interface [polypeptide binding]; other site 1121451001930 conserved gate region; other site 1121451001931 putative PBP binding loops; other site 1121451001932 ABC-ATPase subunit interface; other site 1121451001933 Uncharacterized conserved protein [Function unknown]; Region: COG2014 1121451001934 Domain of unknown function (DUF364); Region: DUF364; pfam04016 1121451001935 mycothiol synthase; Region: mycothiol_MshD; TIGR03448 1121451001936 MoeA_like. This domain is similar to a domain found in a variety of proteins involved in biosynthesis of molybdopterin cofactor, like MoaB, MogA, and MoeA. There this domain is presumed to bind molybdopterin. The exact function of this subgroup is...; Region: MoeA_like; cd03522 1121451001937 putative MPT binding site; other site 1121451001938 4-hydroxybenzoyl-CoA reductase, gamma subunit; Region: 4hydroxCoAred; TIGR03193 1121451001939 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1121451001940 catalytic loop [active] 1121451001941 iron binding site [ion binding]; other site 1121451001942 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 1121451001943 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 1121451001944 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 1121451001945 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 1121451001946 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 1121451001947 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1121451001948 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1121451001949 S-adenosylmethionine binding site [chemical binding]; other site 1121451001950 Putative redox-active protein (C_GCAxxG_C_C); Region: C_GCAxxG_C_C; pfam09719 1121451001951 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG1964 1121451001952 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1121451001953 FeS/SAM binding site; other site 1121451001954 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1121451001955 phenylacetate-CoA ligase; Region: PA_CoA_ligase; TIGR02155 1121451001956 acyl-activating enzyme (AAE) consensus motif; other site 1121451001957 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1121451001958 AMP binding site [chemical binding]; other site 1121451001959 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 1121451001960 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 1121451001961 XdhC Rossmann domain; Region: XdhC_C; pfam13478 1121451001962 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 1121451001963 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 1121451001964 Ligand binding site; other site 1121451001965 metal-binding site 1121451001966 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1121451001967 Zn2+ binding site [ion binding]; other site 1121451001968 Mg2+ binding site [ion binding]; other site 1121451001969 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1121451001970 catalytic core [active] 1121451001971 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 1121451001972 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 1121451001973 active site 1121451001974 NAD binding site [chemical binding]; other site 1121451001975 metal binding site [ion binding]; metal-binding site 1121451001976 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 1121451001977 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 1121451001978 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1121451001979 dimer interface [polypeptide binding]; other site 1121451001980 phosphorylation site [posttranslational modification] 1121451001981 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1121451001982 ATP binding site [chemical binding]; other site 1121451001983 Mg2+ binding site [ion binding]; other site 1121451001984 G-X-G motif; other site 1121451001985 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 1121451001986 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121451001987 active site 1121451001988 phosphorylation site [posttranslational modification] 1121451001989 intermolecular recognition site; other site 1121451001990 dimerization interface [polypeptide binding]; other site 1121451001991 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1121451001992 Walker A motif; other site 1121451001993 ATP binding site [chemical binding]; other site 1121451001994 Walker B motif; other site 1121451001995 arginine finger; other site 1121451001996 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1121451001997 Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176 1121451001998 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 1121451001999 dimer interface [polypeptide binding]; other site 1121451002000 active site 1121451002001 metal binding site [ion binding]; metal-binding site 1121451002002 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 1121451002003 nitrogen fixation negative regulator NifL; Region: nifL_nitrog; TIGR02938 1121451002004 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1121451002005 putative active site [active] 1121451002006 heme pocket [chemical binding]; other site 1121451002007 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1121451002008 ATP binding site [chemical binding]; other site 1121451002009 Mg2+ binding site [ion binding]; other site 1121451002010 G-X-G motif; other site 1121451002011 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1121451002012 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1121451002013 substrate binding pocket [chemical binding]; other site 1121451002014 membrane-bound complex binding site; other site 1121451002015 hinge residues; other site 1121451002016 Response regulator receiver domain; Region: Response_reg; pfam00072 1121451002017 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121451002018 active site 1121451002019 phosphorylation site [posttranslational modification] 1121451002020 intermolecular recognition site; other site 1121451002021 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 1121451002022 dimerization interface [polypeptide binding]; other site 1121451002023 HD domain; Region: HD_5; pfam13487 1121451002024 Response regulator receiver domain; Region: Response_reg; pfam00072 1121451002025 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121451002026 active site 1121451002027 phosphorylation site [posttranslational modification] 1121451002028 intermolecular recognition site; other site 1121451002029 dimerization interface [polypeptide binding]; other site 1121451002030 HDOD domain; Region: HDOD; pfam08668 1121451002031 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1121451002032 Zn2+ binding site [ion binding]; other site 1121451002033 Mg2+ binding site [ion binding]; other site 1121451002034 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 1121451002035 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1121451002036 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1121451002037 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 1121451002038 putative catalytic site [active] 1121451002039 putative metal binding site [ion binding]; other site 1121451002040 putative phosphate binding site [ion binding]; other site 1121451002041 rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565 1121451002042 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 1121451002043 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1121451002044 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1121451002045 binding surface 1121451002046 TPR motif; other site 1121451002047 TPR repeat; Region: TPR_11; pfam13414 1121451002048 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 1121451002049 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 1121451002050 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 1121451002051 catalytic triad [active] 1121451002052 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 1121451002053 active site 1121451002054 DNA polymerase IV; Validated; Region: PRK02406 1121451002055 DNA binding site [nucleotide binding] 1121451002056 cobalt-precorrin-6A synthase; Reviewed; Region: cbiD; PRK00075 1121451002057 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 1121451002058 active site 1121451002059 putative homodimer interface [polypeptide binding]; other site 1121451002060 SAM binding site [chemical binding]; other site 1121451002061 Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242 1121451002062 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1121451002063 S-adenosylmethionine binding site [chemical binding]; other site 1121451002064 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 1121451002065 Diphthamide biosynthesis methyltransferase [Translation, ribosomal structure and biogenesis]; Region: DPH5; COG1798 1121451002066 active site 1121451002067 SAM binding site [chemical binding]; other site 1121451002068 homodimer interface [polypeptide binding]; other site 1121451002069 Uncharacterized protein family UPF0047; Region: UPF0047; pfam01894 1121451002070 Domain of unknown function (DUF4389); Region: DUF4389; pfam14333 1121451002071 Cache domain; Region: Cache_1; pfam02743 1121451002072 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1121451002073 dimerization interface [polypeptide binding]; other site 1121451002074 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 1121451002075 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 1121451002076 Cysteine-rich small domain; Region: zf-like; cl00946 1121451002077 AmmeMemoRadiSam system protein A; Region: AmmeMemoSam_A; TIGR04335 1121451002078 AMMECR1; Region: AMMECR1; pfam01871 1121451002079 Phosphotransferase enzyme family; Region: APH; pfam01636 1121451002080 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 1121451002081 active site 1121451002082 ATP binding site [chemical binding]; other site 1121451002083 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1121451002084 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 1121451002085 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 1121451002086 active site 1121451002087 substrate binding site [chemical binding]; other site 1121451002088 cosubstrate binding site; other site 1121451002089 catalytic site [active] 1121451002090 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 1121451002091 Diphthamide biosynthesis methyltransferase [Translation, ribosomal structure and biogenesis]; Region: DPH5; COG1798 1121451002092 active site 1121451002093 SAM binding site [chemical binding]; other site 1121451002094 homodimer interface [polypeptide binding]; other site 1121451002095 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 1121451002096 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 1121451002097 active site 1121451002098 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 1121451002099 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 1121451002100 HIGH motif; other site 1121451002101 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1121451002102 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 1121451002103 active site 1121451002104 KMSKS motif; other site 1121451002105 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 1121451002106 tRNA binding surface [nucleotide binding]; other site 1121451002107 anticodon binding site; other site 1121451002108 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 1121451002109 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 1121451002110 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 1121451002111 Permease; Region: Permease; pfam02405 1121451002112 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 1121451002113 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 1121451002114 Walker A/P-loop; other site 1121451002115 ATP binding site [chemical binding]; other site 1121451002116 Q-loop/lid; other site 1121451002117 ABC transporter signature motif; other site 1121451002118 Walker B; other site 1121451002119 D-loop; other site 1121451002120 H-loop/switch region; other site 1121451002121 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 1121451002122 mce related protein; Region: MCE; pfam02470 1121451002123 Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; pfam05494 1121451002124 VacJ like lipoprotein; Region: VacJ; cl01073 1121451002125 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 1121451002126 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1121451002127 active site 1121451002128 metal binding site [ion binding]; metal-binding site 1121451002129 homotetramer interface [polypeptide binding]; other site 1121451002130 Multiple antibiotic transporter [Intracellular trafficking and secretion]; Region: MarC; COG2095 1121451002131 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 1121451002132 DEAD/DEAH box helicase; Region: DEAD; pfam00270 1121451002133 ATP binding site [chemical binding]; other site 1121451002134 putative Mg++ binding site [ion binding]; other site 1121451002135 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 1121451002136 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1121451002137 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 1121451002138 FAD binding domain; Region: FAD_binding_4; pfam01565 1121451002139 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 1121451002140 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1121451002141 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1121451002142 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1121451002143 dimerization interface [polypeptide binding]; other site 1121451002144 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 1121451002145 SmpB-tmRNA interface; other site 1121451002146 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 1121451002147 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 1121451002148 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1121451002149 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 1121451002150 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 1121451002151 dimerization domain swap beta strand [polypeptide binding]; other site 1121451002152 regulatory protein interface [polypeptide binding]; other site 1121451002153 active site 1121451002154 regulatory phosphorylation site [posttranslational modification]; other site 1121451002155 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; cl01507 1121451002156 Predicted methyltransferases [General function prediction only]; Region: COG0313 1121451002157 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 1121451002158 putative SAM binding site [chemical binding]; other site 1121451002159 putative homodimer interface [polypeptide binding]; other site 1121451002160 Uncharacterized protein family UPF0102; Region: UPF0102; cl00516 1121451002161 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 1121451002162 RNA/DNA hybrid binding site [nucleotide binding]; other site 1121451002163 active site 1121451002164 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 1121451002165 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 1121451002166 SAM-dependent RNA methyltransferase; Region: Methyltrn_RNA_4; pfam09936 1121451002167 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 1121451002168 RimM N-terminal domain; Region: RimM; pfam01782 1121451002169 PRC-barrel domain; Region: PRC; pfam05239 1121451002170 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 1121451002171 hypothetical protein; Provisional; Region: PRK00468 1121451002172 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 1121451002173 signal recognition particle protein; Provisional; Region: PRK10867 1121451002174 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 1121451002175 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 1121451002176 P loop; other site 1121451002177 GTP binding site [chemical binding]; other site 1121451002178 Signal peptide binding domain; Region: SRP_SPB; pfam02978 1121451002179 tRNA_anti-like; Region: tRNA_anti-like; pfam12869 1121451002180 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 1121451002181 Cysteine-rich domain; Region: CCG; pfam02754 1121451002182 Cysteine-rich domain; Region: CCG; pfam02754 1121451002183 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 1121451002184 putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347 1121451002185 RsbT co-antagonist protein rsbRD N-terminal domain; Region: RsbRD_N; pfam14361 1121451002186 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; cl00959 1121451002187 4Fe-4S dicluster domain; Region: Fer4_17; pfam13534 1121451002188 Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437 1121451002189 4Fe-4S binding domain; Region: Fer4_6; pfam12837 1121451002190 Polysulphide reductase [Energy production and conversion]; Region: COG5557; cl17901 1121451002191 Polysulphide reductase, NrfD; Region: NrfD; pfam03916 1121451002192 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1121451002193 Ligand Binding Site [chemical binding]; other site 1121451002194 Protein of unknown function (DUF342); Region: DUF342; pfam03961 1121451002195 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 1121451002196 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 1121451002197 dimerization interface 3.5A [polypeptide binding]; other site 1121451002198 active site 1121451002199 Uncharacterized conserved protein [Function unknown]; Region: COG3334 1121451002200 flagellar export protein FliJ; Region: flagell_FliJ; TIGR02473 1121451002201 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily. Adenine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_I; cd01990 1121451002202 Ligand Binding Site [chemical binding]; other site 1121451002203 4Fe-4S single cluster domain; Region: Fer4_13; pfam13370 1121451002204 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 1121451002205 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 1121451002206 Walker A/P-loop; other site 1121451002207 ATP binding site [chemical binding]; other site 1121451002208 Q-loop/lid; other site 1121451002209 ABC transporter signature motif; other site 1121451002210 Walker B; other site 1121451002211 D-loop; other site 1121451002212 H-loop/switch region; other site 1121451002213 leucine/isoleucine/valine transporter permease subunit; Provisional; Region: livM; PRK11301 1121451002214 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 1121451002215 TM-ABC transporter signature motif; other site 1121451002216 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1121451002217 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 1121451002218 TM-ABC transporter signature motif; other site 1121451002219 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 1121451002220 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 1121451002221 dimerization interface [polypeptide binding]; other site 1121451002222 ligand binding site [chemical binding]; other site 1121451002223 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 1121451002224 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 1121451002225 Walker A/P-loop; other site 1121451002226 ATP binding site [chemical binding]; other site 1121451002227 Q-loop/lid; other site 1121451002228 ABC transporter signature motif; other site 1121451002229 Walker B; other site 1121451002230 D-loop; other site 1121451002231 H-loop/switch region; other site 1121451002232 chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169 1121451002233 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1121451002234 4Fe-4S dicluster domain; Region: Fer4_17; pfam13534 1121451002235 tricarballylate utilization protein B; Provisional; Region: PRK15033 1121451002236 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; cl00959 1121451002237 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 1121451002238 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 1121451002239 Methyl-viologen-reducing hydrogenase, delta subunit; Region: FlpD; cl00831 1121451002240 Heterodisulfide reductase, subunit A and related polyferredoxins [Energy production and conversion]; Region: HdrA; COG1148 1121451002241 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1121451002242 adenosine phosphosulphate reductase, alpha subunit; Region: aprA; TIGR02061 1121451002243 adenosine phosphosulphate reductase, beta subunit; Region: aprB; TIGR02060 1121451002244 Adenosine-5'-phosphosulfate reductase beta subunit; Region: APS-reductase_C; pfam12139 1121451002245 sulfate adenylyltransferase; Reviewed; Region: sat; PRK04149 1121451002246 ATP-sulfurylase; Region: ATPS; cd00517 1121451002247 active site 1121451002248 HXXH motif; other site 1121451002249 flexible loop; other site 1121451002250 Chorismate mutase [Amino acid transport and metabolism]; Region: PheA; COG1605 1121451002251 5-enolpyruvylshikimate-3-phosphate synthase [Amino acid transport and metabolism]; Region: AroA; COG0128 1121451002252 This domain family includes the Enolpyruvate transferase (EPT) family and the RNA 3' phosphate cyclase family (RTPC). These 2 families differ in that EPT is formed by 3 repeats of an alpha-beta structural domain while RTPC has 3 similar repeats...; Region: EPT_RTPC-like; cl00288 1121451002253 putative active site [active] 1121451002254 aconitate hydratase; Validated; Region: PRK07229 1121451002255 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 1121451002256 substrate binding site [chemical binding]; other site 1121451002257 ligand binding site [chemical binding]; other site 1121451002258 Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215 1121451002259 substrate binding site [chemical binding]; other site 1121451002260 periplasmic folding chaperone; Provisional; Region: PRK10788 1121451002261 SurA N-terminal domain; Region: SurA_N_3; cl07813 1121451002262 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 1121451002263 PPIC-type PPIASE domain; Region: Rotamase_2; cl08278 1121451002264 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 1121451002265 heterotetramer interface [polypeptide binding]; other site 1121451002266 active site pocket [active] 1121451002267 cleavage site 1121451002268 HD domain; Region: HD_3; pfam13023 1121451002269 histidinol-phosphate aminotransferase; Validated; Region: PRK02731 1121451002270 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1121451002271 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1121451002272 homodimer interface [polypeptide binding]; other site 1121451002273 catalytic residue [active] 1121451002274 cytidylate kinase; Provisional; Region: cmk; PRK00023 1121451002275 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 1121451002276 CMP-binding site; other site 1121451002277 The sites determining sugar specificity; other site 1121451002278 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1121451002279 Zn2+ binding site [ion binding]; other site 1121451002280 Mg2+ binding site [ion binding]; other site 1121451002281 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1121451002282 Haloacid dehalogenase-like hydrolase; Region: Hydrolase_6; pfam13344 1121451002283 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1121451002284 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 1121451002285 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1121451002286 UDP-galactopyranose mutase; Region: GLF; pfam03275 1121451002287 HflC protein; Region: hflC; TIGR01932 1121451002288 Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405 1121451002289 Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404 1121451002290 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 1121451002291 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 1121451002292 phosphoglucosamine mutase; Region: Arch_GlmM; TIGR03990 1121451002293 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 1121451002294 active site 1121451002295 substrate binding site [chemical binding]; other site 1121451002296 metal binding site [ion binding]; metal-binding site 1121451002297 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 1121451002298 RNA/DNA hybrid binding site [nucleotide binding]; other site 1121451002299 active site 1121451002300 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1121451002301 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 1121451002302 acyl-activating enzyme (AAE) consensus motif; other site 1121451002303 AMP binding site [chemical binding]; other site 1121451002304 active site 1121451002305 CoA binding site [chemical binding]; other site 1121451002306 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1121451002307 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1121451002308 non-specific DNA binding site [nucleotide binding]; other site 1121451002309 salt bridge; other site 1121451002310 sequence-specific DNA binding site [nucleotide binding]; other site 1121451002311 Cupin domain; Region: Cupin_2; pfam07883 1121451002312 AMP-binding domain protein; Validated; Region: PRK08315 1121451002313 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1121451002314 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 1121451002315 acyl-activating enzyme (AAE) consensus motif; other site 1121451002316 acyl-activating enzyme (AAE) consensus motif; other site 1121451002317 putative AMP binding site [chemical binding]; other site 1121451002318 putative active site [active] 1121451002319 putative CoA binding site [chemical binding]; other site 1121451002320 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1121451002321 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1121451002322 non-specific DNA binding site [nucleotide binding]; other site 1121451002323 salt bridge; other site 1121451002324 sequence-specific DNA binding site [nucleotide binding]; other site 1121451002325 Cupin domain; Region: Cupin_2; pfam07883 1121451002326 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1121451002327 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1121451002328 binding surface 1121451002329 TPR motif; other site 1121451002330 TPR repeat; Region: TPR_11; pfam13414 1121451002331 ribosomal RNA small subunit methyltransferase RsmB; Region: rsmB; TIGR00563 1121451002332 NusB family; Region: NusB; pfam01029 1121451002333 NOL1/NOP2/sun family putative RNA methylase; Region: nop2p; TIGR00446 1121451002334 Protein of unknown function DUF116; Region: DUF116; pfam01976 1121451002335 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 1121451002336 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 1121451002337 putative active site [active] 1121451002338 substrate binding site [chemical binding]; other site 1121451002339 putative cosubstrate binding site; other site 1121451002340 catalytic site [active] 1121451002341 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 1121451002342 substrate binding site [chemical binding]; other site 1121451002343 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 1121451002344 active site 1121451002345 catalytic residues [active] 1121451002346 metal binding site [ion binding]; metal-binding site 1121451002347 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 1121451002348 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 1121451002349 dimer interface [polypeptide binding]; other site 1121451002350 anticodon binding site; other site 1121451002351 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 1121451002352 homodimer interface [polypeptide binding]; other site 1121451002353 motif 1; other site 1121451002354 active site 1121451002355 motif 2; other site 1121451002356 GAD domain; Region: GAD; pfam02938 1121451002357 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 1121451002358 motif 3; other site 1121451002359 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 1121451002360 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 1121451002361 dimer interface [polypeptide binding]; other site 1121451002362 motif 1; other site 1121451002363 active site 1121451002364 motif 2; other site 1121451002365 motif 3; other site 1121451002366 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 1121451002367 anticodon binding site; other site 1121451002368 Protein of unknown function (DUF2628); Region: DUF2628; pfam10947 1121451002369 Caspase domain; Region: Peptidase_C14; pfam00656 1121451002370 tRNA(1-methyladenosine) methyltransferase and related methyltransferases [Translation, ribosomal structure and biogenesis]; Region: GCD14; COG2519 1121451002371 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1121451002372 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1121451002373 Radical SAM superfamily; Region: Radical_SAM; pfam04055 1121451002374 FeS/SAM binding site; other site 1121451002375 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 1121451002376 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 1121451002377 homodimer interface [polypeptide binding]; other site 1121451002378 oligonucleotide binding site [chemical binding]; other site 1121451002379 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases and ATP sulphurylases. The domain forms a apha/beta/apha fold which binds to Adenosine group; Region: Alpha_ANH_like; cd01986 1121451002380 Ligand Binding Site [chemical binding]; other site 1121451002381 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1121451002382 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1121451002383 Ligand Binding Site [chemical binding]; other site 1121451002384 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1121451002385 Ligand Binding Site [chemical binding]; other site 1121451002386 Coproporphyrinogen III oxidase and related Fe-S oxidoreductases [Coenzyme metabolism]; Region: HemN; COG0635 1121451002387 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1121451002388 FeS/SAM binding site; other site 1121451002389 HemN C-terminal domain; Region: HemN_C; pfam06969 1121451002390 serine O-acetyltransferase; Region: cysE; TIGR01172 1121451002391 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 1121451002392 trimer interface [polypeptide binding]; other site 1121451002393 active site 1121451002394 substrate binding site [chemical binding]; other site 1121451002395 CoA binding site [chemical binding]; other site 1121451002396 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1121451002397 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1121451002398 dimer interface [polypeptide binding]; other site 1121451002399 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1121451002400 catalytic residue [active] 1121451002401 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 1121451002402 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 1121451002403 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1121451002404 catalytic residue [active] 1121451002405 Fe-S cluster assembly protein NifU; Region: NifU_proper; TIGR02000 1121451002406 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 1121451002407 trimerization site [polypeptide binding]; other site 1121451002408 active site 1121451002409 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 1121451002410 NifU-like domain; Region: NifU; pfam01106 1121451002411 butyrate kinase; Provisional; Region: PRK03011 1121451002412 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1121451002413 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1121451002414 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1121451002415 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1121451002416 Protein of unknown function (DUF1007); Region: DUF1007; cl01487 1121451002417 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG2215 1121451002418 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1121451002419 active site 1121451002420 ATP binding site [chemical binding]; other site 1121451002421 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1121451002422 substrate binding site [chemical binding]; other site 1121451002423 activation loop (A-loop); other site 1121451002424 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1121451002425 AAA ATPase domain; Region: AAA_16; pfam13191 1121451002426 Predicted ATPase [General function prediction only]; Region: COG3899 1121451002427 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1121451002428 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1121451002429 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 1121451002430 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1121451002431 putative active site [active] 1121451002432 heme pocket [chemical binding]; other site 1121451002433 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1121451002434 dimer interface [polypeptide binding]; other site 1121451002435 phosphorylation site [posttranslational modification] 1121451002436 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1121451002437 ATP binding site [chemical binding]; other site 1121451002438 Mg2+ binding site [ion binding]; other site 1121451002439 G-X-G motif; other site 1121451002440 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1121451002441 Response regulator receiver domain; Region: Response_reg; pfam00072 1121451002442 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121451002443 active site 1121451002444 phosphorylation site [posttranslational modification] 1121451002445 intermolecular recognition site; other site 1121451002446 dimerization interface [polypeptide binding]; other site 1121451002447 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 1121451002448 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 1121451002449 G1 box; other site 1121451002450 putative GEF interaction site [polypeptide binding]; other site 1121451002451 GTP/Mg2+ binding site [chemical binding]; other site 1121451002452 Switch I region; other site 1121451002453 G2 box; other site 1121451002454 G3 box; other site 1121451002455 Switch II region; other site 1121451002456 G4 box; other site 1121451002457 G5 box; other site 1121451002458 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 1121451002459 DEDDy 3'-5' exonuclease domain of WRN and similar proteins; Region: WRN_exo; cd06141 1121451002460 catalytic site [active] 1121451002461 putative active site [active] 1121451002462 putative substrate binding site [chemical binding]; other site 1121451002463 Uncharacterized protein conserved in archaea [Function unknown]; Region: COG3366 1121451002464 Nucleoside recognition; Region: Gate; pfam07670 1121451002465 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 1121451002466 oligomerization interface [polypeptide binding]; other site 1121451002467 active site 1121451002468 metal binding site [ion binding]; metal-binding site 1121451002469 Bacteriophage CI repressor helix-turn-helix domain; Region: Phage_CI_repr; pfam07022 1121451002470 The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cd06462 1121451002471 Catalytic site [active] 1121451002472 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1121451002473 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1121451002474 ATP binding site [chemical binding]; other site 1121451002475 Mg2+ binding site [ion binding]; other site 1121451002476 G-X-G motif; other site 1121451002477 CT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_1; cd04870 1121451002478 ACT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_2; cd04871 1121451002479 phosphoserine phosphatase SerB; Region: serB; TIGR00338 1121451002480 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1121451002481 motif II; other site 1121451002482 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1121451002483 PAS fold; Region: PAS_3; pfam08447 1121451002484 putative active site [active] 1121451002485 heme pocket [chemical binding]; other site 1121451002486 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1121451002487 PAS domain; Region: PAS_9; pfam13426 1121451002488 putative active site [active] 1121451002489 heme pocket [chemical binding]; other site 1121451002490 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1121451002491 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1121451002492 metal binding site [ion binding]; metal-binding site 1121451002493 active site 1121451002494 I-site; other site 1121451002495 Domain of unknown function (DUF4198); Region: DUF4198; pfam10670 1121451002496 Ferrous iron transport protein B; Region: FeoB_N; pfam02421 1121451002497 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 1121451002498 G1 box; other site 1121451002499 GTP/Mg2+ binding site [chemical binding]; other site 1121451002500 Switch I region; other site 1121451002501 G2 box; other site 1121451002502 G3 box; other site 1121451002503 Switch II region; other site 1121451002504 G4 box; other site 1121451002505 G5 box; other site 1121451002506 Nucleoside recognition; Region: Gate; pfam07670 1121451002507 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 1121451002508 Nucleoside recognition; Region: Gate; pfam07670 1121451002509 FeoA domain; Region: FeoA; pfam04023 1121451002510 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1121451002511 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1121451002512 metal binding site [ion binding]; metal-binding site 1121451002513 active site 1121451002514 I-site; other site 1121451002515 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1121451002516 metal binding site 2 [ion binding]; metal-binding site 1121451002517 putative DNA binding helix; other site 1121451002518 metal binding site 1 [ion binding]; metal-binding site 1121451002519 dimer interface [polypeptide binding]; other site 1121451002520 structural Zn2+ binding site [ion binding]; other site 1121451002521 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 1121451002522 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1121451002523 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1121451002524 motif II; other site 1121451002525 Domain of unknown function (DUF4405); Region: DUF4405; pfam14358 1121451002526 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1121451002527 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1121451002528 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1121451002529 FeoA domain; Region: FeoA; pfam04023 1121451002530 FeoA domain; Region: FeoA; pfam04023 1121451002531 FeoA domain; Region: FeoA; cl00838 1121451002532 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14460 1121451002533 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1121451002534 FeS/SAM binding site; other site 1121451002535 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 1121451002536 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 1121451002537 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1121451002538 dimerization interface [polypeptide binding]; other site 1121451002539 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1121451002540 PAS domain; Region: PAS; smart00091 1121451002541 putative active site [active] 1121451002542 heme pocket [chemical binding]; other site 1121451002543 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1121451002544 dimer interface [polypeptide binding]; other site 1121451002545 phosphorylation site [posttranslational modification] 1121451002546 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1121451002547 ATP binding site [chemical binding]; other site 1121451002548 Mg2+ binding site [ion binding]; other site 1121451002549 G-X-G motif; other site 1121451002550 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 1121451002551 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 1121451002552 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 1121451002553 acetyl-CoA synthetase; Provisional; Region: PRK00174 1121451002554 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 1121451002555 active site 1121451002556 CoA binding site [chemical binding]; other site 1121451002557 acyl-activating enzyme (AAE) consensus motif; other site 1121451002558 AMP binding site [chemical binding]; other site 1121451002559 acetate binding site [chemical binding]; other site 1121451002560 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 1121451002561 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121451002562 active site 1121451002563 phosphorylation site [posttranslational modification] 1121451002564 intermolecular recognition site; other site 1121451002565 dimerization interface [polypeptide binding]; other site 1121451002566 LytTr DNA-binding domain; Region: LytTR; smart00850 1121451002567 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1121451002568 metal binding site 2 [ion binding]; metal-binding site 1121451002569 putative DNA binding helix; other site 1121451002570 metal binding site 1 [ion binding]; metal-binding site 1121451002571 dimer interface [polypeptide binding]; other site 1121451002572 structural Zn2+ binding site [ion binding]; other site 1121451002573 Rubrerythrin [Energy production and conversion]; Region: COG1592 1121451002574 Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041 1121451002575 binuclear metal center [ion binding]; other site 1121451002576 Rubredoxin_like; nonheme iron binding domain containing a [Fe(SCys)4] center. The family includes rubredoxins, a small electron transfer protein, and a slightly smaller modular rubredoxin domain present in rubrerythrin and nigerythrin and detected either...; Region: rubredoxin_like; cl00202 1121451002577 iron binding site [ion binding]; other site 1121451002578 desulfoferrodoxin; Region: dfx_rbo; TIGR00320 1121451002579 Desulforedoxin (DSRD) domain; a small non-heme iron domain present in the desulforedoxin (rubredoxin oxidoreductase) and desulfoferrodoxin proteins of some archeael and bacterial methanogens and sulfate/sulfur reducers. Desulforedoxin is a small; Region: DSRD; cd00974 1121451002580 non-heme iron binding site [ion binding]; other site 1121451002581 dimer interface [polypeptide binding]; other site 1121451002582 Superoxide reductase-like (SORL) domain, class I; SORL-domains are present in a family of mononuclear non-heme iron proteins that includes superoxide reductase and desulfoferrodoxin. Superoxide reductase-like proteins scavenge superoxide anion radicals...; Region: SORL_Dfx_classI; cd03171 1121451002583 non-heme iron binding site [ion binding]; other site 1121451002584 dimer interface [polypeptide binding]; other site 1121451002585 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 11123953, 11751865, 12101220, 12142437, 12529359, 12586421, 20573621, 9660187; Product type c : carrier 1121451002586 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 11123953, 11751865, 12101220, 12142437, 12529359, 12586421, 20573621, 9660187; Product type c : carrier 1121451002587 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 11123953, 11751865, 12101220, 12142437, 12529359, 12586421, 20573621, 9660187; Product type c : carrier 1121451002588 HEAT-like repeat; Region: HEAT_EZ; pfam13513 1121451002589 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 1121451002590 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 1121451002591 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 1121451002592 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 1121451002593 Ferritin-like domain; Region: Ferritin; pfam00210 1121451002594 ferroxidase diiron center [ion binding]; other site 1121451002595 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1121451002596 dimerization interface [polypeptide binding]; other site 1121451002597 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 1121451002598 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1121451002599 putative active site [active] 1121451002600 heme pocket [chemical binding]; other site 1121451002601 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1121451002602 dimer interface [polypeptide binding]; other site 1121451002603 phosphorylation site [posttranslational modification] 1121451002604 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1121451002605 ATP binding site [chemical binding]; other site 1121451002606 Mg2+ binding site [ion binding]; other site 1121451002607 G-X-G motif; other site 1121451002608 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_1; cd03169 1121451002609 intracellular protease, PfpI family; Region: PfpI; TIGR01382 1121451002610 conserved cys residue [active] 1121451002611 Ribbon-helix-helix domain; Region: RHH_4; pfam13467 1121451002612 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 1121451002613 Metal binding protein HemV-2. These proteins are predicted to function as initial receptors in ABC transport of metal ions. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and ligand binding...; Region: HemV-2; cd01147 1121451002614 putative metal binding site [ion binding]; other site 1121451002615 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 1121451002616 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1121451002617 ABC-ATPase subunit interface; other site 1121451002618 dimer interface [polypeptide binding]; other site 1121451002619 putative PBP binding regions; other site 1121451002620 phosphonate ABC transporter, ATP-binding protein; Region: ABC_phnC; TIGR02315 1121451002621 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1121451002622 Walker A/P-loop; other site 1121451002623 ATP binding site [chemical binding]; other site 1121451002624 Q-loop/lid; other site 1121451002625 ABC transporter signature motif; other site 1121451002626 Walker B; other site 1121451002627 D-loop; other site 1121451002628 H-loop/switch region; other site 1121451002629 Formylmethanofuran dehydrogenase subunit E [Energy production and conversion]; Region: COG2191 1121451002630 FmdE, Molybdenum formylmethanofuran dehydrogenase operon; Region: FmdE; pfam02663 1121451002631 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; pfam01258 1121451002632 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1121451002633 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1121451002634 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 1121451002635 ligand binding site [chemical binding]; other site 1121451002636 hypothetical protein; Provisional; Region: PRK09256 1121451002637 This uncharacterized conserved protein belongs to a family of iron-molybdenum cluster-binding proteins that includes NifX, NifB, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of...; Region: MTH1175; cd00851 1121451002638 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3012 1121451002639 SEC-C motif; Region: SEC-C; pfam02810 1121451002640 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cl00197 1121451002641 active site 1121451002642 Hemerythrin; Region: Hemerythrin; cd12107 1121451002643 Fe binding site [ion binding]; other site 1121451002644 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 1121451002645 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 1121451002646 putative dimer interface [polypeptide binding]; other site 1121451002647 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 1121451002648 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 1121451002649 putative dimer interface [polypeptide binding]; other site 1121451002650 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1121451002651 FKBP-type peptidyl-prolyl cis-trans isomerases 2 [Posttranslational modification, protein turnover, chaperones]; Region: SlpA; COG1047 1121451002652 Trm112p-like protein; Region: Trm112p; cl01066 1121451002653 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 1121451002654 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 1121451002655 active site 1121451002656 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 1121451002657 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 1121451002658 Peptidase family U32; Region: Peptidase_U32; pfam01136 1121451002659 FOG: CBS domain [General function prediction only]; Region: COG0517 1121451002660 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the acetoin utilization proteins in bacteria. Acetoin is a product of fermentative metabolism in many prokaryotic and eukaryotic microorganisms. They produce...; Region: CBS_pair_ACT_assoc2; cd04585 1121451002661 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 1121451002662 Protein of unknown function (DUF2959); Region: DUF2959; pfam11172 1121451002663 Helix-turn-helix domain; Region: HTH_17; pfam12728 1121451002664 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 1121451002665 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 1121451002666 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 1121451002667 ABC-type thiamine transport system, ATPase component [Coenzyme metabolism]; Region: ThiQ; COG3840 1121451002668 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1121451002669 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1121451002670 active site 1121451002671 metal binding site [ion binding]; metal-binding site 1121451002672 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1121451002673 AAA domain; Region: AAA_23; pfam13476 1121451002674 Walker A/P-loop; other site 1121451002675 ATP binding site [chemical binding]; other site 1121451002676 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 1121451002677 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1121451002678 S-adenosylmethionine binding site [chemical binding]; other site 1121451002679 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 1121451002680 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 1121451002681 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 1121451002682 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 1121451002683 DNA binding site [nucleotide binding] 1121451002684 catalytic residue [active] 1121451002685 H2TH interface [polypeptide binding]; other site 1121451002686 putative catalytic residues [active] 1121451002687 turnover-facilitating residue; other site 1121451002688 intercalation triad [nucleotide binding]; other site 1121451002689 8OG recognition residue [nucleotide binding]; other site 1121451002690 putative reading head residues; other site 1121451002691 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1121451002692 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1121451002693 Protein of unknown function, DUF399; Region: DUF399; pfam04187 1121451002694 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1121451002695 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 1121451002696 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1121451002697 acyl-activating enzyme (AAE) consensus motif; other site 1121451002698 AMP binding site [chemical binding]; other site 1121451002699 active site 1121451002700 CoA binding site [chemical binding]; other site 1121451002701 Cache domain; Region: Cache_1; pfam02743 1121451002702 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 1121451002703 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1121451002704 dimerization interface [polypeptide binding]; other site 1121451002705 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1121451002706 dimer interface [polypeptide binding]; other site 1121451002707 putative CheW interface [polypeptide binding]; other site 1121451002708 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1121451002709 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1121451002710 DNA-binding site [nucleotide binding]; DNA binding site 1121451002711 FCD domain; Region: FCD; pfam07729 1121451002712 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 1121451002713 fructuronate transporter; Provisional; Region: PRK10034; cl15264 1121451002714 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1121451002715 TPR motif; other site 1121451002716 binding surface 1121451002717 Domain of unknown function (DUF4147); Region: DUF4147; pfam13660 1121451002718 Putative glycerate kinase [Carbohydrate transport and metabolism]; Region: GckA; COG2379 1121451002719 MOFRL family; Region: MOFRL; pfam05161 1121451002720 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 1121451002721 PAS domain; Region: PAS_9; pfam13426 1121451002722 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1121451002723 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1121451002724 dimer interface [polypeptide binding]; other site 1121451002725 putative CheW interface [polypeptide binding]; other site 1121451002726 Amidohydrolase; Region: Amidohydro_2; pfam04909 1121451002727 Surface antigen [Cell envelope biogenesis, outer membrane]; Region: LipA; COG4520 1121451002728 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1121451002729 S-adenosylmethionine binding site [chemical binding]; other site 1121451002730 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 1121451002731 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 1121451002732 dimer interface [polypeptide binding]; other site 1121451002733 decamer (pentamer of dimers) interface [polypeptide binding]; other site 1121451002734 catalytic triad [active] 1121451002735 peroxidatic and resolving cysteines [active] 1121451002736 Predicted Zn-dependent peptidases, insulinase-like [General function prediction only]; Region: COG1026 1121451002737 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1121451002738 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1121451002739 Peptidase M16C associated; Region: M16C_assoc; pfam08367 1121451002740 exosortase A system-associated amidotransferase 1; Region: eps_aminotran_1; TIGR03108 1121451002741 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 1121451002742 active site 1121451002743 dimer interface [polypeptide binding]; other site 1121451002744 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 1121451002745 Ligand Binding Site [chemical binding]; other site 1121451002746 Molecular Tunnel; other site 1121451002747 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1121451002748 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 1121451002749 putative ADP-binding pocket [chemical binding]; other site 1121451002750 Escherichia coli YdjC-like family of proteins; Region: YdjC; cd10808 1121451002751 putative active site [active] 1121451002752 YdjC motif; other site 1121451002753 Mg binding site [ion binding]; other site 1121451002754 putative homodimer interface [polypeptide binding]; other site 1121451002755 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 1121451002756 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 1121451002757 Ligand binding site; other site 1121451002758 Putative Catalytic site; other site 1121451002759 DXD motif; other site 1121451002760 flagellar motor protein MotS; Reviewed; Region: PRK06925 1121451002761 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1121451002762 ligand binding site [chemical binding]; other site 1121451002763 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 1121451002764 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 1121451002765 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1121451002766 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1121451002767 ligand binding site [chemical binding]; other site 1121451002768 flexible hinge region; other site 1121451002769 FliG C-terminal domain; Region: FliG_C; pfam01706 1121451002770 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 1121451002771 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 1121451002772 Putative catalytic domain, repeat 1, of uncharacterized proteins similar to bacterial cardiolipin synthase; Region: PLDc_CLS_unchar1_1; cd09156 1121451002773 putative active site [active] 1121451002774 catalytic site [active] 1121451002775 Putative catalytic domain, repeat 2, of uncharacterized proteins similar to bacterial cardiolipin synthase; Region: PLDc_CLS_unchar1_2; cd09162 1121451002776 putative active site [active] 1121451002777 catalytic site [active] 1121451002778 Zinc dependent phospholipase C; Region: Zn_dep_PLPC; pfam00882 1121451002779 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 1121451002780 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 1121451002781 tandem repeat interface [polypeptide binding]; other site 1121451002782 oligomer interface [polypeptide binding]; other site 1121451002783 active site residues [active] 1121451002784 chlorohydrolase; Provisional; Region: PRK08418 1121451002785 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1121451002786 active site 1121451002787 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 1121451002788 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1121451002789 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1121451002790 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1121451002791 dihydroorotase; Validated; Region: pyrC; PRK09357 1121451002792 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 1121451002793 active site 1121451002794 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 1121451002795 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1121451002796 Zn2+ binding site [ion binding]; other site 1121451002797 Mg2+ binding site [ion binding]; other site 1121451002798 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 1121451002799 diphosphate--fructose-6-phosphate 1-phosphotransferase; Provisional; Region: PRK06830 1121451002800 6-phosphofructokinase; Region: PLN02884 1121451002801 active site 1121451002802 ADP/pyrophosphate binding site [chemical binding]; other site 1121451002803 dimerization interface [polypeptide binding]; other site 1121451002804 allosteric effector site; other site 1121451002805 fructose-1,6-bisphosphate binding site; other site 1121451002806 Domain of unknown function (DUF1992); Region: DUF1992; cl08096 1121451002807 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 1121451002808 mce related protein; Region: MCE; pfam02470 1121451002809 MbeD/MobD like; Region: MbeD_MobD; pfam04899 1121451002810 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 1121451002811 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 1121451002812 Walker A/P-loop; other site 1121451002813 ATP binding site [chemical binding]; other site 1121451002814 Q-loop/lid; other site 1121451002815 ABC transporter signature motif; other site 1121451002816 Walker B; other site 1121451002817 D-loop; other site 1121451002818 H-loop/switch region; other site 1121451002819 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 1121451002820 Permease; Region: Permease; pfam02405 1121451002821 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1121451002822 anti sigma factor interaction site; other site 1121451002823 regulatory phosphorylation site [posttranslational modification]; other site 1121451002824 GAF domain; Region: GAF; pfam01590 1121451002825 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 1121451002826 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 1121451002827 ADP-heptose synthase, bifunctional sugar kinase/adenylyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaE; COG2870 1121451002828 RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172 1121451002829 putative ribose interaction site [chemical binding]; other site 1121451002830 putative ADP binding site [chemical binding]; other site 1121451002831 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 1121451002832 ParB-like nuclease domain; Region: ParB; smart00470 1121451002833 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1121451002834 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1121451002835 P-loop; other site 1121451002836 Magnesium ion binding site [ion binding]; other site 1121451002837 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1121451002838 Magnesium ion binding site [ion binding]; other site 1121451002839 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1121451002840 UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253 1121451002841 putative NAD(P) binding site [chemical binding]; other site 1121451002842 active site 1121451002843 putative substrate binding site [chemical binding]; other site 1121451002844 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 1121451002845 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 1121451002846 Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030 1121451002847 Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763 1121451002848 active site 1121451002849 NfeD-like C-terminal, partner-binding; Region: NfeD; pfam01957 1121451002850 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 1121451002851 Flavoprotein; Region: Flavoprotein; pfam02441 1121451002852 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 1121451002853 V-type ATP synthase subunit I; Validated; Region: PRK05771 1121451002854 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 1121451002855 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 1121451002856 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 1121451002857 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 1121451002858 2-ketoisovalerate ferredoxin reductase; Validated; Region: PRK07119 1121451002859 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 1121451002860 dimer interface [polypeptide binding]; other site 1121451002861 PYR/PP interface [polypeptide binding]; other site 1121451002862 TPP binding site [chemical binding]; other site 1121451002863 substrate binding site [chemical binding]; other site 1121451002864 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, beta subunit [Energy production and conversion]; Region: PorB; COG1013 1121451002865 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 1121451002866 TPP-binding site [chemical binding]; other site 1121451002867 2-oxoglutarate ferredoxin oxidoreductase subunit gamma; Validated; Region: PRK08537 1121451002868 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; pfam01558 1121451002869 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 1121451002870 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 1121451002871 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 1121451002872 shikimate binding site; other site 1121451002873 NAD(P) binding site [chemical binding]; other site 1121451002874 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1121451002875 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 1121451002876 NAD(P) binding site [chemical binding]; other site 1121451002877 catalytic residues [active] 1121451002878 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1121451002879 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1121451002880 catalytic residue [active] 1121451002881 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1121451002882 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1121451002883 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1121451002884 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 1121451002885 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 1121451002886 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1121451002887 flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700 1121451002888 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 1121451002889 Flagellar biosynthesis protein, FliO; Region: FliO; pfam04347 1121451002890 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 1121451002891 Flagellar basal body-associated protein FliL; Region: FliL; pfam03748 1121451002892 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1121451002893 ligand binding site [chemical binding]; other site 1121451002894 Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360 1121451002895 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 1121451002896 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1121451002897 ligand binding site [chemical binding]; other site 1121451002898 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 1121451002899 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 1121451002900 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 1121451002901 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1121451002902 catalytic residue [active] 1121451002903 GTPase Era; Reviewed; Region: era; PRK00089 1121451002904 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 1121451002905 G1 box; other site 1121451002906 GTP/Mg2+ binding site [chemical binding]; other site 1121451002907 Switch I region; other site 1121451002908 G2 box; other site 1121451002909 Switch II region; other site 1121451002910 G3 box; other site 1121451002911 G4 box; other site 1121451002912 G5 box; other site 1121451002913 KH domain; Region: KH_2; pfam07650 1121451002914 G-X-X-G motif; other site 1121451002915 DNA topoisomerase I; Validated; Region: PRK06599 1121451002916 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 1121451002917 active site 1121451002918 interdomain interaction site; other site 1121451002919 putative metal-binding site [ion binding]; other site 1121451002920 nucleotide binding site [chemical binding]; other site 1121451002921 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 1121451002922 domain I; other site 1121451002923 DNA binding groove [nucleotide binding] 1121451002924 phosphate binding site [ion binding]; other site 1121451002925 domain II; other site 1121451002926 domain III; other site 1121451002927 nucleotide binding site [chemical binding]; other site 1121451002928 catalytic site [active] 1121451002929 domain IV; other site 1121451002930 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1121451002931 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1121451002932 Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551 1121451002933 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1121451002934 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1121451002935 Hpt domain; Region: Hpt; pfam01627 1121451002936 putative binding surface; other site 1121451002937 active site 1121451002938 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 1121451002939 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 1121451002940 Protein export membrane protein; Region: SecD_SecF; cl14618 1121451002941 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1121451002942 HlyD family secretion protein; Region: HlyD_3; pfam13437 1121451002943 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1121451002944 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1121451002945 WHG domain; Region: WHG; pfam13305 1121451002946 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1121451002947 Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437 1121451002948 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121451002949 active site 1121451002950 phosphorylation site [posttranslational modification] 1121451002951 intermolecular recognition site; other site 1121451002952 dimerization interface [polypeptide binding]; other site 1121451002953 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1121451002954 Zn2+ binding site [ion binding]; other site 1121451002955 Mg2+ binding site [ion binding]; other site 1121451002956 CHASE domain; Region: CHASE; cl01369 1121451002957 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1121451002958 PAS fold; Region: PAS_3; pfam08447 1121451002959 putative active site [active] 1121451002960 heme pocket [chemical binding]; other site 1121451002961 PAS domain S-box; Region: sensory_box; TIGR00229 1121451002962 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1121451002963 PAS domain; Region: PAS_9; pfam13426 1121451002964 putative active site [active] 1121451002965 heme pocket [chemical binding]; other site 1121451002966 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1121451002967 His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512 1121451002968 dimer interface [polypeptide binding]; other site 1121451002969 phosphorylation site [posttranslational modification] 1121451002970 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1121451002971 ATP binding site [chemical binding]; other site 1121451002972 Mg2+ binding site [ion binding]; other site 1121451002973 G-X-G motif; other site 1121451002974 Protein of unknown function (DUF3431); Region: DUF3431; pfam11913 1121451002975 pH-dependent sodium/proton antiporter; Reviewed; Region: nhaA; PRK09560 1121451002976 ferric uptake regulator; Provisional; Region: fur; PRK09462 1121451002977 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1121451002978 metal binding site 2 [ion binding]; metal-binding site 1121451002979 putative DNA binding helix; other site 1121451002980 metal binding site 1 [ion binding]; metal-binding site 1121451002981 dimer interface [polypeptide binding]; other site 1121451002982 structural Zn2+ binding site [ion binding]; other site 1121451002983 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 1121451002984 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 1121451002985 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 1121451002986 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 1121451002987 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 1121451002988 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1121451002989 molybdopterin cofactor binding site; other site 1121451002990 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cd02775 1121451002991 molybdopterin cofactor binding site; other site 1121451002992 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 1121451002993 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 1121451002994 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1121451002995 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 1121451002996 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1121451002997 intersubunit interface [polypeptide binding]; other site 1121451002998 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 1121451002999 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 1121451003000 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1121451003001 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1121451003002 ABC-ATPase subunit interface; other site 1121451003003 dimer interface [polypeptide binding]; other site 1121451003004 putative PBP binding regions; other site 1121451003005 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 1121451003006 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1121451003007 intersubunit interface [polypeptide binding]; other site 1121451003008 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1121451003009 DNA gyrase subunit A; Validated; Region: PRK05560 1121451003010 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 1121451003011 CAP-like domain; other site 1121451003012 active site 1121451003013 primary dimer interface [polypeptide binding]; other site 1121451003014 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1121451003015 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1121451003016 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1121451003017 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1121451003018 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1121451003019 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1121451003020 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 1121451003021 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1121451003022 ATP binding site [chemical binding]; other site 1121451003023 Mg2+ binding site [ion binding]; other site 1121451003024 G-X-G motif; other site 1121451003025 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1121451003026 anchoring element; other site 1121451003027 dimer interface [polypeptide binding]; other site 1121451003028 ATP binding site [chemical binding]; other site 1121451003029 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 1121451003030 active site 1121451003031 putative metal-binding site [ion binding]; other site 1121451003032 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1121451003033 DNA polymerase III subunit beta; Provisional; Region: PRK14947 1121451003034 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 1121451003035 putative DNA binding surface [nucleotide binding]; other site 1121451003036 dimer interface [polypeptide binding]; other site 1121451003037 beta-clamp/clamp loader binding surface; other site 1121451003038 beta-clamp/translesion DNA polymerase binding surface; other site 1121451003039 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 1121451003040 DnaA N-terminal domain; Region: DnaA_N; pfam11638 1121451003041 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1121451003042 Walker A motif; other site 1121451003043 ATP binding site [chemical binding]; other site 1121451003044 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 1121451003045 DnaA box-binding interface [nucleotide binding]; other site 1121451003046 Domain of unknown function DUF39; Region: DUF39; pfam01837 1121451003047 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1121451003048 EamA-like transporter family; Region: EamA; pfam00892 1121451003049 EamA-like transporter family; Region: EamA; pfam00892 1121451003050 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 1121451003051 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1121451003052 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1121451003053 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 1121451003054 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1121451003055 motif II; other site 1121451003056 Uncharacterized Fe-S center protein [General function prediction only]; Region: COG2768 1121451003057 Uncharacterized conserved protein [Function unknown]; Region: COG2006 1121451003058 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 1121451003059 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 1121451003060 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 1121451003061 FtsX-like permease family; Region: FtsX; pfam02687 1121451003062 cell division ATP-binding protein FtsE; Region: FtsE; TIGR02673 1121451003063 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1121451003064 Walker A/P-loop; other site 1121451003065 ATP binding site [chemical binding]; other site 1121451003066 Q-loop/lid; other site 1121451003067 ABC transporter signature motif; other site 1121451003068 Walker B; other site 1121451003069 D-loop; other site 1121451003070 H-loop/switch region; other site 1121451003071 aspartate aminotransferase; Provisional; Region: PRK05764 1121451003072 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1121451003073 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1121451003074 homodimer interface [polypeptide binding]; other site 1121451003075 catalytic residue [active] 1121451003076 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 1121451003077 dimer interface [polypeptide binding]; other site 1121451003078 active site 1121451003079 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 1121451003080 dimer interface [polypeptide binding]; other site 1121451003081 active site 1121451003082 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1121451003083 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1121451003084 dimer interface [polypeptide binding]; other site 1121451003085 phosphorylation site [posttranslational modification] 1121451003086 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1121451003087 ATP binding site [chemical binding]; other site 1121451003088 Mg2+ binding site [ion binding]; other site 1121451003089 G-X-G motif; other site 1121451003090 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 1121451003091 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121451003092 active site 1121451003093 phosphorylation site [posttranslational modification] 1121451003094 intermolecular recognition site; other site 1121451003095 dimerization interface [polypeptide binding]; other site 1121451003096 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1121451003097 Walker A motif; other site 1121451003098 ATP binding site [chemical binding]; other site 1121451003099 Walker B motif; other site 1121451003100 arginine finger; other site 1121451003101 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 1121451003102 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1121451003103 Aldehyde:ferredoxin oxidoreductase [Energy production and conversion]; Region: COG2414 1121451003104 Aldehyde ferredoxin oxidoreductase, N-terminal domain; Region: AFOR_N; smart00790 1121451003105 Aldehyde ferredoxin oxidoreductase, domains 2 & 3; Region: AFOR_C; pfam01314 1121451003106 HAMP domain; Region: HAMP; pfam00672 1121451003107 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1121451003108 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1121451003109 dimer interface [polypeptide binding]; other site 1121451003110 putative CheW interface [polypeptide binding]; other site 1121451003111 S-ribosylhomocysteinase; Provisional; Region: PRK02260 1121451003112 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 1121451003113 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 1121451003114 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1121451003115 dimerization interface [polypeptide binding]; other site 1121451003116 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1121451003117 putative DNA binding site [nucleotide binding]; other site 1121451003118 putative Zn2+ binding site [ion binding]; other site 1121451003119 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1121451003120 dimerization interface [polypeptide binding]; other site 1121451003121 Glycerophosphodiester phosphodiesterase domain similar to Escherichia coli periplasmic phosphodiesterase (GlpQ) include uncharacterized proteins; Region: GDPD_EcGlpQ_like_1; cd08560 1121451003122 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 1121451003123 putative active site [active] 1121451003124 catalytic site [active] 1121451003125 putative metal binding site [ion binding]; other site 1121451003126 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 1121451003127 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1121451003128 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1121451003129 DNA-binding site [nucleotide binding]; DNA binding site 1121451003130 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1121451003131 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1121451003132 homodimer interface [polypeptide binding]; other site 1121451003133 catalytic residue [active] 1121451003134 4Fe-4S binding domain; Region: Fer4; pfam00037 1121451003135 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 1121451003136 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1121451003137 GAF domain; Region: GAF; pfam01590 1121451003138 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 1121451003139 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 1121451003140 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1121451003141 Glutaredoxin-like domain protein; Region: GlrX_arch; TIGR02187 1121451003142 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1121451003143 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1121451003144 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 1121451003145 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1121451003146 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1121451003147 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 1121451003148 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1121451003149 FeS/SAM binding site; other site 1121451003150 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 1121451003151 HIT family signature motif; other site 1121451003152 catalytic residue [active] 1121451003153 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1121451003154 IHF - DNA interface [nucleotide binding]; other site 1121451003155 IHF dimer interface [polypeptide binding]; other site 1121451003156 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 1121451003157 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 1121451003158 Sporulation related domain; Region: SPOR; pfam05036 1121451003159 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1121451003160 AAA domain; Region: AAA_32; pfam13654 1121451003161 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 1121451003162 Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; pfam09527 1121451003163 ATP synthase I chain; Region: ATP_synt_I; pfam03899 1121451003164 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 1121451003165 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 1121451003166 ATP synthase subunit C; Region: ATP-synt_C; cl00466 1121451003167 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 1121451003168 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 1121451003169 CoA binding domain; Region: CoA_binding; pfam02629 1121451003170 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 1121451003171 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121451003172 active site 1121451003173 phosphorylation site [posttranslational modification] 1121451003174 intermolecular recognition site; other site 1121451003175 dimerization interface [polypeptide binding]; other site 1121451003176 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1121451003177 Walker A motif; other site 1121451003178 ATP binding site [chemical binding]; other site 1121451003179 Walker B motif; other site 1121451003180 arginine finger; other site 1121451003181 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1121451003182 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1121451003183 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1121451003184 putative substrate translocation pore; other site 1121451003185 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1121451003186 putative substrate translocation pore; other site 1121451003187 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; cl17726 1121451003188 alkyl hydroperoxide reductase subunit F; Region: AhpF; TIGR03140 1121451003189 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 1121451003190 Predicted phosphoesterases, related to the Icc protein [General function prediction only]; Region: COG2129 1121451003191 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1121451003192 active site 1121451003193 metal binding site [ion binding]; metal-binding site 1121451003194 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 1121451003195 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 1121451003196 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 1121451003197 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 1121451003198 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 1121451003199 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1121451003200 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121451003201 active site 1121451003202 phosphorylation site [posttranslational modification] 1121451003203 intermolecular recognition site; other site 1121451003204 dimerization interface [polypeptide binding]; other site 1121451003205 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1121451003206 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1121451003207 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1121451003208 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1121451003209 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1121451003210 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1121451003211 metal binding site [ion binding]; metal-binding site 1121451003212 active site 1121451003213 I-site; other site 1121451003214 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1121451003215 dimerization interface [polypeptide binding]; other site 1121451003216 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1121451003217 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1121451003218 dimer interface [polypeptide binding]; other site 1121451003219 phosphorylation site [posttranslational modification] 1121451003220 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1121451003221 ATP binding site [chemical binding]; other site 1121451003222 Mg2+ binding site [ion binding]; other site 1121451003223 G-X-G motif; other site 1121451003224 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1121451003225 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121451003226 active site 1121451003227 phosphorylation site [posttranslational modification] 1121451003228 intermolecular recognition site; other site 1121451003229 dimerization interface [polypeptide binding]; other site 1121451003230 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1121451003231 DNA binding site [nucleotide binding] 1121451003232 Protein of unknown function (DUF3365); Region: DUF3365; pfam11845 1121451003233 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1121451003234 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1121451003235 dimer interface [polypeptide binding]; other site 1121451003236 putative CheW interface [polypeptide binding]; other site 1121451003237 Response regulator receiver domain; Region: Response_reg; pfam00072 1121451003238 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121451003239 active site 1121451003240 phosphorylation site [posttranslational modification] 1121451003241 intermolecular recognition site; other site 1121451003242 dimerization interface [polypeptide binding]; other site 1121451003243 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 1121451003244 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 1121451003245 chemotaxis-specific methylesterase; Provisional; Region: PRK12555 1121451003246 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121451003247 active site 1121451003248 phosphorylation site [posttranslational modification] 1121451003249 intermolecular recognition site; other site 1121451003250 CheB methylesterase; Region: CheB_methylest; pfam01339 1121451003251 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 1121451003252 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1121451003253 putative binding surface; other site 1121451003254 active site 1121451003255 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1121451003256 putative binding surface; other site 1121451003257 active site 1121451003258 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1121451003259 ATP binding site [chemical binding]; other site 1121451003260 Mg2+ binding site [ion binding]; other site 1121451003261 G-X-G motif; other site 1121451003262 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 1121451003263 Response regulator receiver domain; Region: Response_reg; pfam00072 1121451003264 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121451003265 active site 1121451003266 phosphorylation site [posttranslational modification] 1121451003267 intermolecular recognition site; other site 1121451003268 dimerization interface [polypeptide binding]; other site 1121451003269 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cd00588 1121451003270 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 1121451003271 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1121451003272 S-adenosylmethionine binding site [chemical binding]; other site 1121451003273 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1121451003274 binding surface 1121451003275 TPR motif; other site 1121451003276 TPR repeat; Region: TPR_11; pfam13414 1121451003277 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 1121451003278 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1121451003279 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1121451003280 dimer interface [polypeptide binding]; other site 1121451003281 putative CheW interface [polypeptide binding]; other site 1121451003282 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 1121451003283 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1121451003284 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1121451003285 conserved hypothetical integral membrane protein; Region: TIGR00697 1121451003286 Sporulation related domain; Region: SPOR; pfam05036 1121451003287 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 1121451003288 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 1121451003289 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 1121451003290 active site 1121451003291 HIGH motif; other site 1121451003292 KMSK motif region; other site 1121451003293 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 1121451003294 tRNA binding surface [nucleotide binding]; other site 1121451003295 anticodon binding site; other site 1121451003296 S-adenosyl-l-methionine hydroxide adenosyltransferase; Region: SAM_adeno_trans; pfam01887 1121451003297 cobalamin synthase; Reviewed; Region: cobS; PRK00235 1121451003298 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1121451003299 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1121451003300 phosphorylation site [posttranslational modification] 1121451003301 dimer interface [polypeptide binding]; other site 1121451003302 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1121451003303 ATP binding site [chemical binding]; other site 1121451003304 Mg2+ binding site [ion binding]; other site 1121451003305 G-X-G motif; other site 1121451003306 Cache domain; Region: Cache_2; cl07034 1121451003307 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 1121451003308 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1121451003309 dimerization interface [polypeptide binding]; other site 1121451003310 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 1121451003311 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1121451003312 putative active site [active] 1121451003313 heme pocket [chemical binding]; other site 1121451003314 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1121451003315 dimer interface [polypeptide binding]; other site 1121451003316 phosphorylation site [posttranslational modification] 1121451003317 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1121451003318 ATP binding site [chemical binding]; other site 1121451003319 Mg2+ binding site [ion binding]; other site 1121451003320 G-X-G motif; other site 1121451003321 acetyl-CoA synthetase; Provisional; Region: PRK00174 1121451003322 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 1121451003323 active site 1121451003324 CoA binding site [chemical binding]; other site 1121451003325 acyl-activating enzyme (AAE) consensus motif; other site 1121451003326 AMP binding site [chemical binding]; other site 1121451003327 acetate binding site [chemical binding]; other site 1121451003328 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 1121451003329 CoA binding domain; Region: CoA_binding_2; pfam13380 1121451003330 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 1121451003331 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 1121451003332 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1121451003333 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1121451003334 Uncharacterized protein conserved in archaea (DUF2139); Region: DUF2139; cl01925 1121451003335 helicase/secretion neighborhood putative DEAH-box helicase; Region: DECH_helic; TIGR03817 1121451003336 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1121451003337 ATP binding site [chemical binding]; other site 1121451003338 putative Mg++ binding site [ion binding]; other site 1121451003339 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1121451003340 nucleotide binding region [chemical binding]; other site 1121451003341 ATP-binding site [chemical binding]; other site 1121451003342 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 1121451003343 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 1121451003344 active site 1121451003345 substrate binding site [chemical binding]; other site 1121451003346 catalytic site [active] 1121451003347 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 1121451003348 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1121451003349 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 1121451003350 serine/threonine transporter SstT; Provisional; Region: PRK13628 1121451003351 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1121451003352 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA; cl00391 1121451003353 active site clefts [active] 1121451003354 zinc binding site [ion binding]; other site 1121451003355 dimer interface [polypeptide binding]; other site 1121451003356 Peptidase family C69; Region: Peptidase_C69; cl17793 1121451003357 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 1121451003358 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1121451003359 Response regulator receiver domain; Region: Response_reg; pfam00072 1121451003360 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121451003361 active site 1121451003362 phosphorylation site [posttranslational modification] 1121451003363 intermolecular recognition site; other site 1121451003364 dimerization interface [polypeptide binding]; other site 1121451003365 uncharacterized bacterial and archaeal solute carrier 6 subfamily; solute-binding domain; Region: SLC6sbd_u1; cd10334 1121451003366 Na2 binding site [ion binding]; other site 1121451003367 putative substrate binding site 1 [chemical binding]; other site 1121451003368 Na binding site 1 [ion binding]; other site 1121451003369 putative substrate binding site 2 [chemical binding]; other site 1121451003370 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 1121451003371 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121451003372 active site 1121451003373 phosphorylation site [posttranslational modification] 1121451003374 intermolecular recognition site; other site 1121451003375 dimerization interface [polypeptide binding]; other site 1121451003376 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1121451003377 Walker A motif; other site 1121451003378 ATP binding site [chemical binding]; other site 1121451003379 Walker B motif; other site 1121451003380 arginine finger; other site 1121451003381 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1121451003382 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1121451003383 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121451003384 active site 1121451003385 phosphorylation site [posttranslational modification] 1121451003386 intermolecular recognition site; other site 1121451003387 dimerization interface [polypeptide binding]; other site 1121451003388 Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437 1121451003389 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1121451003390 Zn2+ binding site [ion binding]; other site 1121451003391 Mg2+ binding site [ion binding]; other site 1121451003392 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 1121451003393 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1121451003394 dimerization interface [polypeptide binding]; other site 1121451003395 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 1121451003396 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1121451003397 putative active site [active] 1121451003398 heme pocket [chemical binding]; other site 1121451003399 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1121451003400 dimer interface [polypeptide binding]; other site 1121451003401 phosphorylation site [posttranslational modification] 1121451003402 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1121451003403 ATP binding site [chemical binding]; other site 1121451003404 Mg2+ binding site [ion binding]; other site 1121451003405 G-X-G motif; other site 1121451003406 Domain of unknown function (DUF4390); Region: DUF4390; pfam14334 1121451003407 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 1121451003408 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 1121451003409 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 1121451003410 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 1121451003411 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cl02931 1121451003412 Bacterial protein of unknown function (DUF883); Region: DUF883; cl01888 1121451003413 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 1121451003414 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1121451003415 putative active site [active] 1121451003416 heme pocket [chemical binding]; other site 1121451003417 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1121451003418 dimer interface [polypeptide binding]; other site 1121451003419 phosphorylation site [posttranslational modification] 1121451003420 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1121451003421 ATP binding site [chemical binding]; other site 1121451003422 Mg2+ binding site [ion binding]; other site 1121451003423 G-X-G motif; other site 1121451003424 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1121451003425 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121451003426 active site 1121451003427 phosphorylation site [posttranslational modification] 1121451003428 intermolecular recognition site; other site 1121451003429 dimerization interface [polypeptide binding]; other site 1121451003430 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 1121451003431 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 1121451003432 TPP-binding site [chemical binding]; other site 1121451003433 dimer interface [polypeptide binding]; other site 1121451003434 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1121451003435 PYR/PP interface [polypeptide binding]; other site 1121451003436 dimer interface [polypeptide binding]; other site 1121451003437 TPP binding site [chemical binding]; other site 1121451003438 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1121451003439 Ribose/Galactose Isomerase; Region: LacAB_rpiB; pfam02502 1121451003440 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1121451003441 binding surface 1121451003442 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1121451003443 TPR motif; other site 1121451003444 TPR repeat; Region: TPR_11; pfam13414 1121451003445 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1121451003446 binding surface 1121451003447 TPR motif; other site 1121451003448 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1121451003449 binding surface 1121451003450 TPR motif; other site 1121451003451 TPR repeat; Region: TPR_11; pfam13414 1121451003452 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1121451003453 binding surface 1121451003454 TPR motif; other site 1121451003455 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 1121451003456 Zn2+ binding site [ion binding]; other site 1121451003457 Mg2+ binding site [ion binding]; other site 1121451003458 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 1121451003459 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 1121451003460 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1121451003461 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1121451003462 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1121451003463 DNA binding residues [nucleotide binding] 1121451003464 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105 1121451003465 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 1121451003466 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 1121451003467 substrate binding pocket [chemical binding]; other site 1121451003468 dimer interface [polypeptide binding]; other site 1121451003469 inhibitor binding site; inhibition site 1121451003470 B12 binding domain of corrinoid proteins. A family of small methanogenic corrinoid proteins that bind methyl-Co(III) 5-hydroxybenzimidazolylcobamide as a cofactor. They play a role on the methanogenesis from trimethylamine, dimethylamine or...; Region: corrinoid_protein_B12-BD; cd02070 1121451003471 methyltransferase cognate corrinoid proteins, Methanosarcina family; Region: pyl_corrinoid; TIGR02370 1121451003472 B12 binding site [chemical binding]; other site 1121451003473 cobalt ligand [ion binding]; other site 1121451003474 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 1121451003475 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1121451003476 catalytic residues [active] 1121451003477 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1121451003478 Coenzyme A binding pocket [chemical binding]; other site 1121451003479 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1121451003480 active site 1121451003481 zinc-ribbon domain; Region: zinc_ribbon_5; pfam13719 1121451003482 Protein of unknown function (DUF3426); Region: DUF3426; pfam11906 1121451003483 DNA repair protein RadA; Provisional; Region: PRK11823 1121451003484 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1121451003485 Walker A motif; other site 1121451003486 ATP binding site [chemical binding]; other site 1121451003487 Walker B motif; other site 1121451003488 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 1121451003489 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 1121451003490 active site 1121451003491 UDP-N-acetylglucosamine 2-epimerase; Region: Epimerase_2; pfam02350 1121451003492 homodimer interface [polypeptide binding]; other site 1121451003493 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 1121451003494 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 1121451003495 dimer interface [polypeptide binding]; other site 1121451003496 active site 1121451003497 CoA binding pocket [chemical binding]; other site 1121451003498 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 1121451003499 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 1121451003500 glycosyltransferase, TIGR04182 family; Region: glyco_TIGR04182 1121451003501 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 1121451003502 Ligand binding site; other site 1121451003503 Putative Catalytic site; other site 1121451003504 DXD motif; other site 1121451003505 Predicted membrane protein [Function unknown]; Region: COG2246 1121451003506 GtrA-like protein; Region: GtrA; pfam04138 1121451003507 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 1121451003508 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 1121451003509 putative active site [active] 1121451003510 CAAX protease self-immunity; Region: Abi; pfam02517 1121451003511 type II secretion system protein D; Region: type_II_gspD; TIGR02517 1121451003512 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 1121451003513 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 1121451003514 Type II/IV secretion system protein; Region: T2SE; pfam00437 1121451003515 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 1121451003516 Walker A motif; other site 1121451003517 ATP binding site [chemical binding]; other site 1121451003518 Walker B motif; other site 1121451003519 Uncharacterized membrane protein, required for N-linked glycosylation [General function prediction only]; Region: COG1287 1121451003520 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 1121451003521 DNA-binding interface [nucleotide binding]; DNA binding site 1121451003522 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 1121451003523 Integrase core domain; Region: rve; pfam00665 1121451003524 Integrase core domain; Region: rve_3; pfam13683 1121451003525 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 1121451003526 active site 1121451003527 catalytic site [active] 1121451003528 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1121451003529 short chain dehydrogenase; Provisional; Region: PRK12937 1121451003530 NAD(P) binding site [chemical binding]; other site 1121451003531 active site 1121451003532 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1121451003533 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 1121451003534 NAD(P) binding site [chemical binding]; other site 1121451003535 active site 1121451003536 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1121451003537 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1121451003538 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1121451003539 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1121451003540 WcxM-like, Left-handed parallel beta-Helix (LbH) N-terminal domain: This group is composed of Xanthomonas campestris WcxM and proteins with similarity to the WcxM N-terminal domain. WcxM is thought to be bifunctional, catalyzing both the isomerization...; Region: LbH_WxcM_N_like; cd03358 1121451003541 putative trimer interface [polypeptide binding]; other site 1121451003542 putative active site [active] 1121451003543 putative substrate binding site [chemical binding]; other site 1121451003544 putative CoA binding site [chemical binding]; other site 1121451003545 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1121451003546 Methyltransferase domain; Region: Methyltransf_11; pfam08241 1121451003547 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1121451003548 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1121451003549 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Region: lipid_A_lpxD; TIGR01853 1121451003550 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1121451003551 putative trimer interface [polypeptide binding]; other site 1121451003552 putative CoA binding site [chemical binding]; other site 1121451003553 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 1121451003554 Predicted enzyme involved in methoxymalonyl-ACP biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FkbH; COG3882 1121451003555 Acid Phosphatase; Region: Acid_PPase; cl17256 1121451003556 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 1121451003557 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1121451003558 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 1121451003559 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 1121451003560 trimer interface [polypeptide binding]; other site 1121451003561 active site 1121451003562 substrate binding site [chemical binding]; other site 1121451003563 CoA binding site [chemical binding]; other site 1121451003564 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 1121451003565 extended (e) SDRs; Region: SDR_e; cd08946 1121451003566 NAD(P) binding site [chemical binding]; other site 1121451003567 substrate binding site [chemical binding]; other site 1121451003568 active site 1121451003569 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 1121451003570 catalytic triad [active] 1121451003571 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 1121451003572 active site 1121451003573 oxyanion hole [active] 1121451003574 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 1121451003575 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1121451003576 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1121451003577 S-adenosylmethionine binding site [chemical binding]; other site 1121451003578 Aminoglycoside 3-N-acetyltransferase; Region: Antibiotic_NAT; cl01051 1121451003579 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 1121451003580 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1121451003581 acyl-activating enzyme (AAE) consensus motif; other site 1121451003582 AMP binding site [chemical binding]; other site 1121451003583 active site 1121451003584 CoA binding site [chemical binding]; other site 1121451003585 hypothetical protein; Validated; Region: PRK06201 1121451003586 Demethylmenaquinone methyltransferase [Coenzyme metabolism]; Region: MenG; COG0684 1121451003587 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 1121451003588 4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase,; Validated; Region: PRK08195 1121451003589 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974 1121451003590 active site 1121451003591 catalytic residues [active] 1121451003592 metal binding site [ion binding]; metal-binding site 1121451003593 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 1121451003594 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1121451003595 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1121451003596 homodimer interface [polypeptide binding]; other site 1121451003597 catalytic residue [active] 1121451003598 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 1121451003599 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 1121451003600 NodB motif; other site 1121451003601 active site 1121451003602 metal binding site [ion binding]; metal-binding site 1121451003603 Capsule polysaccharide export protein [Cell envelope biogenesis, outer membrane]; Region: KpsS; COG3562 1121451003604 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain associated with the NTP (Nucleotidyl transferase) domain downstream. CBS is a small domain originally identified in cystathionine beta-synthase and subsequently...; Region: CBS_pair_NTP_transferase_assoc; cd04607 1121451003605 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 1121451003606 NTP_trnasferase_like_2 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_2; cd06426 1121451003607 Substrate binding site; other site 1121451003608 metal-binding site 1121451003609 N-acetylneuraminate synthase; Region: NeuB_NnaB; TIGR03569 1121451003610 NeuB family; Region: NeuB; pfam03102 1121451003611 C-terminal SAF domain of sialic acid synthetase; Region: SAF_NeuB_like; cd11615 1121451003612 NeuB binding interface [polypeptide binding]; other site 1121451003613 putative substrate binding site [chemical binding]; other site 1121451003614 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1121451003615 active site 1121451003616 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1121451003617 Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360 1121451003618 sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570 1121451003619 putative trimer interface [polypeptide binding]; other site 1121451003620 putative CoA binding site [chemical binding]; other site 1121451003621 CMP-NeuAc_Synthase activates N-acetylneuraminic acid by adding CMP moiety; Region: CMP-NeuAc_Synthase; cd02513 1121451003622 ligand binding site; other site 1121451003623 tetramer interface; other site 1121451003624 aminotransferase, LLPSF_NHT_00031 family; Region: NHT_00031; TIGR04181 1121451003625 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 1121451003626 inhibitor-cofactor binding pocket; inhibition site 1121451003627 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1121451003628 catalytic residue [active] 1121451003629 Arna decarboxylase_like, extended (e) SDRs; Region: Arna_like_SDR_e; cd05257 1121451003630 NAD dependent epimerase/dehydratase, LLPSF_EDH_00030 family; Region: EDH_00030; TIGR04180 1121451003631 NAD binding site [chemical binding]; other site 1121451003632 substrate binding site [chemical binding]; other site 1121451003633 active site 1121451003634 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1121451003635 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1121451003636 putative trimer interface [polypeptide binding]; other site 1121451003637 putative CoA binding site [chemical binding]; other site 1121451003638 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1121451003639 FeS/SAM binding site; other site 1121451003640 Radical SAM superfamily; Region: Radical_SAM; pfam04055 1121451003641 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 1121451003642 trimer interface [polypeptide binding]; other site 1121451003643 active site 1121451003644 UDP-GlcNAc binding site [chemical binding]; other site 1121451003645 lipid binding site [chemical binding]; lipid-binding site 1121451003646 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 1121451003647 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1121451003648 acyl-activating enzyme (AAE) consensus motif; other site 1121451003649 active site 1121451003650 AMP binding site [chemical binding]; other site 1121451003651 CoA binding site [chemical binding]; other site 1121451003652 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1121451003653 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1121451003654 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 1121451003655 Walker A/P-loop; other site 1121451003656 ATP binding site [chemical binding]; other site 1121451003657 Q-loop/lid; other site 1121451003658 ABC transporter signature motif; other site 1121451003659 Walker B; other site 1121451003660 D-loop; other site 1121451003661 H-loop/switch region; other site 1121451003662 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1121451003663 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1121451003664 NAD(P) binding site [chemical binding]; other site 1121451003665 active site 1121451003666 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1121451003667 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 1121451003668 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1121451003669 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1121451003670 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1121451003671 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1121451003672 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1121451003673 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1121451003674 putative trimer interface [polypeptide binding]; other site 1121451003675 WcxM-like, Left-handed parallel beta-Helix (LbH) N-terminal domain: This group is composed of Xanthomonas campestris WcxM and proteins with similarity to the WcxM N-terminal domain. WcxM is thought to be bifunctional, catalyzing both the isomerization...; Region: LbH_WxcM_N_like; cd03358 1121451003676 putative CoA binding site [chemical binding]; other site 1121451003677 putative trimer interface [polypeptide binding]; other site 1121451003678 putative active site [active] 1121451003679 putative substrate binding site [chemical binding]; other site 1121451003680 putative CoA binding site [chemical binding]; other site 1121451003681 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 1121451003682 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 1121451003683 inhibitor-cofactor binding pocket; inhibition site 1121451003684 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1121451003685 catalytic residue [active] 1121451003686 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1121451003687 dimerization interface [polypeptide binding]; other site 1121451003688 putative DNA binding site [nucleotide binding]; other site 1121451003689 putative Zn2+ binding site [ion binding]; other site 1121451003690 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 1121451003691 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1121451003692 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 1121451003693 NAD(P) binding site [chemical binding]; other site 1121451003694 homodimer interface [polypeptide binding]; other site 1121451003695 substrate binding site [chemical binding]; other site 1121451003696 active site 1121451003697 aminotransferase, LLPSF_NHT_00031 family; Region: NHT_00031; TIGR04181 1121451003698 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 1121451003699 inhibitor-cofactor binding pocket; inhibition site 1121451003700 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1121451003701 catalytic residue [active] 1121451003702 Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360 1121451003703 sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570 1121451003704 putative trimer interface [polypeptide binding]; other site 1121451003705 putative CoA binding site [chemical binding]; other site 1121451003706 Bacterial sugar transferase; Region: Bac_transf; pfam02397 1121451003707 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1121451003708 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 1121451003709 putative ADP-binding pocket [chemical binding]; other site 1121451003710 exosortase A system-associated amidotransferase 1; Region: eps_aminotran_1; TIGR03108 1121451003711 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 1121451003712 active site 1121451003713 dimer interface [polypeptide binding]; other site 1121451003714 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 1121451003715 Ligand Binding Site [chemical binding]; other site 1121451003716 Molecular Tunnel; other site 1121451003717 D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892 1121451003718 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 1121451003719 putative active site [active] 1121451003720 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 1121451003721 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 1121451003722 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1121451003723 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1121451003724 putative type II secretion protein GspC; Provisional; Region: PRK09681 1121451003725 Type IV pilus biogenesis; Region: Pilus_PilP; pfam11356 1121451003726 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1121451003727 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121451003728 Response regulator receiver domain; Region: Response_reg; pfam00072 1121451003729 active site 1121451003730 phosphorylation site [posttranslational modification] 1121451003731 intermolecular recognition site; other site 1121451003732 dimerization interface [polypeptide binding]; other site 1121451003733 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1121451003734 ATP binding site [chemical binding]; other site 1121451003735 Mg2+ binding site [ion binding]; other site 1121451003736 G-X-G motif; other site 1121451003737 FOG: WD40 repeat [General function prediction only]; Region: COG2319 1121451003738 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 1121451003739 structural tetrad; other site 1121451003740 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 1121451003741 type II secretion system protein G; Region: typeII_sec_gspG; TIGR01710 1121451003742 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 1121451003743 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 1121451003744 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 1121451003745 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830 1121451003746 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830 1121451003747 Type II secretion system (T2SS), protein K; Region: T2SK; pfam03934 1121451003748 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1121451003749 S-adenosylmethionine binding site [chemical binding]; other site 1121451003750 Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069 1121451003751 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1121451003752 phosphate binding site [ion binding]; other site 1121451003753 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1121451003754 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 1121451003755 AMIN domain; Region: AMIN; pfam11741 1121451003756 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 1121451003757 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1121451003758 active site 1121451003759 metal binding site [ion binding]; metal-binding site 1121451003760 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 1121451003761 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 1121451003762 putative active site [active] 1121451003763 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 1121451003764 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 1121451003765 Substrate binding site; other site 1121451003766 Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050 1121451003767 Archaeal ATPase; Region: Arch_ATPase; pfam01637 1121451003768 Curli production assembly/transport component CsgG; Region: CsgG; cl17434 1121451003769 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1121451003770 binding surface 1121451003771 TPR motif; other site 1121451003772 Integrase core domain; Region: rve; pfam00665 1121451003773 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK08270 1121451003774 ATP cone domain; Region: ATP-cone; pfam03477 1121451003775 Class III ribonucleotide reductase; Region: RNR_III; cd01675 1121451003776 effector binding site; other site 1121451003777 active site 1121451003778 Zn binding site [ion binding]; other site 1121451003779 glycine loop; other site 1121451003780 Cache domain; Region: Cache_1; pfam02743 1121451003781 HAMP domain; Region: HAMP; pfam00672 1121451003782 PAS fold; Region: PAS_4; pfam08448 1121451003783 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 1121451003784 putative active site [active] 1121451003785 heme pocket [chemical binding]; other site 1121451003786 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1121451003787 dimer interface [polypeptide binding]; other site 1121451003788 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 1121451003789 putative CheW interface [polypeptide binding]; other site 1121451003790 Cache domain; Region: Cache_1; pfam02743 1121451003791 HAMP domain; Region: HAMP; pfam00672 1121451003792 PAS fold; Region: PAS_4; pfam08448 1121451003793 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1121451003794 dimer interface [polypeptide binding]; other site 1121451003795 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 1121451003796 putative CheW interface [polypeptide binding]; other site 1121451003797 sodium/proton antiporter; Reviewed; Region: nhaB; PRK09547 1121451003798 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 1121451003799 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1121451003800 putative trimer interface [polypeptide binding]; other site 1121451003801 putative CoA binding site [chemical binding]; other site 1121451003802 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 1121451003803 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 1121451003804 transmembrane helices; other site 1121451003805 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 1121451003806 Response regulator receiver domain; Region: Response_reg; pfam00072 1121451003807 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121451003808 active site 1121451003809 phosphorylation site [posttranslational modification] 1121451003810 intermolecular recognition site; other site 1121451003811 dimerization interface [polypeptide binding]; other site 1121451003812 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1121451003813 PAS domain; Region: PAS_9; pfam13426 1121451003814 putative active site [active] 1121451003815 heme pocket [chemical binding]; other site 1121451003816 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 1121451003817 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1121451003818 Walker A motif; other site 1121451003819 ATP binding site [chemical binding]; other site 1121451003820 Walker B motif; other site 1121451003821 arginine finger; other site 1121451003822 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1121451003823 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1121451003824 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1121451003825 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 1121451003826 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 1121451003827 active site 1121451003828 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 1121451003829 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 1121451003830 L-threonine-O-3-phosphate decarboxylase; Region: L_thr_O3P_dcar; TIGR01140 1121451003831 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1121451003832 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1121451003833 homodimer interface [polypeptide binding]; other site 1121451003834 catalytic residue [active] 1121451003835 cobyric acid synthase; Provisional; Region: PRK00784 1121451003836 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1121451003837 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 1121451003838 catalytic triad [active] 1121451003839 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1121451003840 TPR motif; other site 1121451003841 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1121451003842 binding surface 1121451003843 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1121451003844 GAF domain; Region: GAF_3; pfam13492 1121451003845 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1121451003846 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1121451003847 metal binding site [ion binding]; metal-binding site 1121451003848 active site 1121451003849 I-site; other site 1121451003850 Response regulator receiver domain; Region: Response_reg; pfam00072 1121451003851 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121451003852 active site 1121451003853 phosphorylation site [posttranslational modification] 1121451003854 intermolecular recognition site; other site 1121451003855 dimerization interface [polypeptide binding]; other site 1121451003856 ROS/MUCR transcriptional regulator protein; Region: ROS_MUCR; pfam05443 1121451003857 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 1121451003858 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 1121451003859 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1121451003860 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 1121451003861 putative metal binding site; other site 1121451003862 WxcM-like, C-terminal; Region: FdtA; pfam05523 1121451003863 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 1121451003864 DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041 1121451003865 inhibitor-cofactor binding pocket; inhibition site 1121451003866 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1121451003867 catalytic residue [active] 1121451003868 putative oxidoreductase; Provisional; Region: PRK12831 1121451003869 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1121451003870 Alanine dehydrogenase/PNT, C-terminal domain; Region: AlaDh_PNT_C; smart01002 1121451003871 ferredoxin-NADP(+) reductase subunit alpha; Reviewed; Region: PRK06222 1121451003872 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase-like proteins. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)...; Region: DHOD_e_trans_like1; cd06219 1121451003873 FAD binding pocket [chemical binding]; other site 1121451003874 FAD binding motif [chemical binding]; other site 1121451003875 phosphate binding motif [ion binding]; other site 1121451003876 beta-alpha-beta structure motif; other site 1121451003877 NAD binding pocket [chemical binding]; other site 1121451003878 Iron coordination center [ion binding]; other site 1121451003879 GTP-binding protein LepA; Provisional; Region: PRK05433 1121451003880 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 1121451003881 G1 box; other site 1121451003882 putative GEF interaction site [polypeptide binding]; other site 1121451003883 GTP/Mg2+ binding site [chemical binding]; other site 1121451003884 Switch I region; other site 1121451003885 G2 box; other site 1121451003886 G3 box; other site 1121451003887 Switch II region; other site 1121451003888 G4 box; other site 1121451003889 G5 box; other site 1121451003890 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 1121451003891 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 1121451003892 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 1121451003893 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 1121451003894 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1121451003895 Catalytic site [active] 1121451003896 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 1121451003897 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 1121451003898 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1121451003899 Walker A motif; other site 1121451003900 ATP binding site [chemical binding]; other site 1121451003901 Walker B motif; other site 1121451003902 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 1121451003903 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 1121451003904 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 1121451003905 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 1121451003906 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 1121451003907 active site 1121451003908 Protoporphyrinogen oxidase [Coenzyme metabolism]; Region: HemY; COG1232 1121451003909 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1121451003910 PBP superfamily domain; Region: PBP_like_2; cl17296 1121451003911 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1121451003912 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 1121451003913 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1121451003914 dimer interface [polypeptide binding]; other site 1121451003915 conserved gate region; other site 1121451003916 putative PBP binding loops; other site 1121451003917 ABC-ATPase subunit interface; other site 1121451003918 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 1121451003919 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1121451003920 dimer interface [polypeptide binding]; other site 1121451003921 conserved gate region; other site 1121451003922 putative PBP binding loops; other site 1121451003923 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1121451003924 ABC-ATPase subunit interface; other site 1121451003925 Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242 1121451003926 rod shape-determining protein MreB; Provisional; Region: PRK13927 1121451003927 MreB and similar proteins; Region: MreB_like; cd10225 1121451003928 nucleotide binding site [chemical binding]; other site 1121451003929 Mg binding site [ion binding]; other site 1121451003930 putative protofilament interaction site [polypeptide binding]; other site 1121451003931 RodZ interaction site [polypeptide binding]; other site 1121451003932 rod shape-determining protein MreC; Provisional; Region: PRK13922 1121451003933 rod shape-determining protein MreC; Region: MreC; pfam04085 1121451003934 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 1121451003935 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1121451003936 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1121451003937 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 1121451003938 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 1121451003939 F0F1 ATP synthase subunit B'; Validated; Region: PRK07353 1121451003940 ATP synthase B/B' CF(0); Region: ATP-synt_B; pfam00430 1121451003941 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 1121451003942 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 1121451003943 F0F1 ATP synthase subunit delta; Provisional; Region: PRK13429 1121451003944 F0F1-type ATP synthase, delta subunit (mitochondrial oligomycin sensitivity protein) [Energy production and conversion]; Region: AtpH; cl17210 1121451003945 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 1121451003946 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1121451003947 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 1121451003948 beta subunit interaction interface [polypeptide binding]; other site 1121451003949 Walker A motif; other site 1121451003950 ATP binding site [chemical binding]; other site 1121451003951 Walker B motif; other site 1121451003952 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1121451003953 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 1121451003954 core domain interface [polypeptide binding]; other site 1121451003955 delta subunit interface [polypeptide binding]; other site 1121451003956 epsilon subunit interface [polypeptide binding]; other site 1121451003957 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 1121451003958 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1121451003959 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 1121451003960 alpha subunit interaction interface [polypeptide binding]; other site 1121451003961 Walker A motif; other site 1121451003962 ATP binding site [chemical binding]; other site 1121451003963 Walker B motif; other site 1121451003964 inhibitor binding site; inhibition site 1121451003965 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1121451003966 F0F1 ATP synthase subunit epsilon; Provisional; Region: atpC; PRK13446 1121451003967 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 1121451003968 gamma subunit interface [polypeptide binding]; other site 1121451003969 epsilon subunit interface [polypeptide binding]; other site 1121451003970 LBP interface [polypeptide binding]; other site 1121451003971 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14356 1121451003972 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 1121451003973 Substrate binding site; other site 1121451003974 Mg++ binding site; other site 1121451003975 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 1121451003976 active site 1121451003977 substrate binding site [chemical binding]; other site 1121451003978 CoA binding site [chemical binding]; other site 1121451003979 Cell division protein ZapA; Region: ZapA; pfam05164 1121451003980 phosphodiesterase; Provisional; Region: PRK12704 1121451003981 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1121451003982 Zn2+ binding site [ion binding]; other site 1121451003983 Mg2+ binding site [ion binding]; other site 1121451003984 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 1121451003985 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1121451003986 putative active site [active] 1121451003987 metal binding site [ion binding]; metal-binding site 1121451003988 homodimer binding site [polypeptide binding]; other site 1121451003989 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 1121451003990 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 1121451003991 active site 1121451003992 HIGH motif; other site 1121451003993 dimer interface [polypeptide binding]; other site 1121451003994 KMSKS motif; other site 1121451003995 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1121451003996 RNA binding surface [nucleotide binding]; other site 1121451003997 Protein of unknown function, DUF606; Region: DUF606; pfam04657 1121451003998 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337 1121451003999 UbiA prenyltransferase family; Region: UbiA; pfam01040 1121451004000 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1121451004001 PAS domain; Region: PAS_9; pfam13426 1121451004002 putative active site [active] 1121451004003 heme pocket [chemical binding]; other site 1121451004004 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1121451004005 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1121451004006 dimer interface [polypeptide binding]; other site 1121451004007 putative CheW interface [polypeptide binding]; other site 1121451004008 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 1121451004009 Histone deacetylases and histone-like deacetylases, classII; Region: HDAC_classII; cd09992 1121451004010 active site 1121451004011 Zn binding site [ion binding]; other site 1121451004012 Nitrous oxide-stimulated promoter; Region: YgbA_NO; cl08119 1121451004013 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 1121451004014 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 1121451004015 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 1121451004016 GAF domain; Region: GAF_3; pfam13492 1121451004017 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 1121451004018 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1121451004019 Walker A motif; other site 1121451004020 ATP binding site [chemical binding]; other site 1121451004021 Walker B motif; other site 1121451004022 arginine finger; other site 1121451004023 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1121451004024 Metal binding protein ZntC. These proteins are predicted to function as initial receptors in ABC transport of metal ions. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and ligand binding...; Region: ZntC; cd01018 1121451004025 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 1121451004026 putative metal binding residues [ion binding]; other site 1121451004027 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 1121451004028 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 1121451004029 Nitrogen regulatory protein P-II; Region: P-II; smart00938 1121451004030 UTP:GlnB (protein PII) uridylyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: GlnD; COG2844 1121451004031 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 1121451004032 metal binding triad; other site 1121451004033 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 1121451004034 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1121451004035 Zn2+ binding site [ion binding]; other site 1121451004036 Mg2+ binding site [ion binding]; other site 1121451004037 ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900 1121451004038 ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD; Region: ACT_UUR-ACR-like; cd04873 1121451004039 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 1121451004040 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 1121451004041 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 1121451004042 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 1121451004043 AIR carboxylase; Region: AIRC; pfam00731 1121451004044 Response regulator receiver domain; Region: Response_reg; pfam00072 1121451004045 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121451004046 active site 1121451004047 phosphorylation site [posttranslational modification] 1121451004048 intermolecular recognition site; other site 1121451004049 dimerization interface [polypeptide binding]; other site 1121451004050 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086 1121451004051 putative binding surface; other site 1121451004052 active site 1121451004053 heat shock protein 90; Provisional; Region: PRK05218 1121451004054 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1121451004055 ATP binding site [chemical binding]; other site 1121451004056 Mg2+ binding site [ion binding]; other site 1121451004057 G-X-G motif; other site 1121451004058 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1121451004059 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 1121451004060 DNA binding residues [nucleotide binding] 1121451004061 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1121451004062 nucleotide binding site [chemical binding]; other site 1121451004063 Type III pantothenate kinase; Region: Pan_kinase; cl17198 1121451004064 enolase; Provisional; Region: eno; PRK00077 1121451004065 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 1121451004066 dimer interface [polypeptide binding]; other site 1121451004067 metal binding site [ion binding]; metal-binding site 1121451004068 substrate binding pocket [chemical binding]; other site 1121451004069 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14184 1121451004070 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 1121451004071 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 1121451004072 homodimer interface [polypeptide binding]; other site 1121451004073 NADP binding site [chemical binding]; other site 1121451004074 substrate binding site [chemical binding]; other site 1121451004075 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1121451004076 Zn2+ binding site [ion binding]; other site 1121451004077 Mg2+ binding site [ion binding]; other site 1121451004078 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 1121451004079 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1121451004080 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1121451004081 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 1121451004082 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086 1121451004083 putative binding surface; other site 1121451004084 active site 1121451004085 Alpha-acetolactate decarboxylase; Region: AAL_decarboxy; pfam03306 1121451004086 CheD chemotactic sensory transduction; Region: CheD; cl00810 1121451004087 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1121451004088 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 1121451004089 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1121451004090 anti sigma factor interaction site; other site 1121451004091 regulatory phosphorylation site [posttranslational modification]; other site 1121451004092 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1121451004093 putative substrate translocation pore; other site 1121451004094 Protein of unknown function DUF45; Region: DUF45; pfam01863 1121451004095 aspartate aminotransferase; Provisional; Region: PRK06836 1121451004096 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1121451004097 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1121451004098 homodimer interface [polypeptide binding]; other site 1121451004099 catalytic residue [active] 1121451004100 helicase 45; Provisional; Region: PTZ00424 1121451004101 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1121451004102 ATP binding site [chemical binding]; other site 1121451004103 Mg++ binding site [ion binding]; other site 1121451004104 motif III; other site 1121451004105 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1121451004106 nucleotide binding region [chemical binding]; other site 1121451004107 ATP-binding site [chemical binding]; other site 1121451004108 Methylamine utilisation protein MauE; Region: MauE; pfam07291 1121451004109 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1121451004110 active site residue [active] 1121451004111 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 1121451004112 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 1121451004113 dimerization interface [polypeptide binding]; other site 1121451004114 PAS domain; Region: PAS; smart00091 1121451004115 PAS fold; Region: PAS_4; pfam08448 1121451004116 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1121451004117 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1121451004118 dimer interface [polypeptide binding]; other site 1121451004119 putative CheW interface [polypeptide binding]; other site 1121451004120 glycyl-radical enzyme activating protein family; Region: PFLE_PFLC; TIGR02494 1121451004121 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 1121451004122 glycyl radical enzyme, PFL2/glycerol dehydratase family; Region: PFL2-3; TIGR01774 1121451004123 Pyruvate formate lyase 2 and related enzymes; Region: PFL2_DhaB_BssA; cd01677 1121451004124 dimer interface [polypeptide binding]; other site 1121451004125 active site 1121451004126 glycine loop; other site 1121451004127 Domain of unknown function (DUF336); Region: DUF336; pfam03928 1121451004128 Sensory domain found in PocR; Region: PocR; pfam10114 1121451004129 Predicted sensor domain [Signal transduction mechanisms / Transcription]; Region: PocR; COG4936 1121451004130 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1121451004131 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1121451004132 putative active site [active] 1121451004133 heme pocket [chemical binding]; other site 1121451004134 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 1121451004135 dimer interface [polypeptide binding]; other site 1121451004136 phosphorylation site [posttranslational modification] 1121451004137 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1121451004138 ATP binding site [chemical binding]; other site 1121451004139 Mg2+ binding site [ion binding]; other site 1121451004140 G-X-G motif; other site 1121451004141 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 1121451004142 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121451004143 active site 1121451004144 phosphorylation site [posttranslational modification] 1121451004145 intermolecular recognition site; other site 1121451004146 dimerization interface [polypeptide binding]; other site 1121451004147 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1121451004148 Walker A motif; other site 1121451004149 ATP binding site [chemical binding]; other site 1121451004150 Walker B motif; other site 1121451004151 arginine finger; other site 1121451004152 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1121451004153 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 1121451004154 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 1121451004155 active site 1121451004156 dimer interface [polypeptide binding]; other site 1121451004157 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 1121451004158 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 1121451004159 active site 1121451004160 trimer interface [polypeptide binding]; other site 1121451004161 allosteric site; other site 1121451004162 active site lid [active] 1121451004163 hexamer (dimer of trimers) interface [polypeptide binding]; other site 1121451004164 PTS system N-acetyl glucosamine specific transporter subunits IIABC; Provisional; Region: PRK10255 1121451004165 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1121451004166 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1121451004167 active site turn [active] 1121451004168 phosphorylation site [posttranslational modification] 1121451004169 PTS system glucose-specific transporter subunit; Provisional; Region: PRK09439 1121451004170 HPr interaction site; other site 1121451004171 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1121451004172 active site 1121451004173 phosphorylation site [posttranslational modification] 1121451004174 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 1121451004175 dimerization domain swap beta strand [polypeptide binding]; other site 1121451004176 regulatory protein interface [polypeptide binding]; other site 1121451004177 active site 1121451004178 regulatory phosphorylation site [posttranslational modification]; other site 1121451004179 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 1121451004180 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 1121451004181 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1121451004182 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 1121451004183 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 1121451004184 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1121451004185 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1121451004186 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1121451004187 RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399 1121451004188 Protein of unknown function (DUF1611); Region: DUF1611; pfam07755 1121451004189 Predicted amino acid racemase [Amino acid transport and metabolism]; Region: COG3457 1121451004190 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase-like 1; Region: PLPDE_III_AR_like_1; cd06815 1121451004191 active site 1121451004192 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1121451004193 dimer interface [polypeptide binding]; other site 1121451004194 substrate binding site [chemical binding]; other site 1121451004195 catalytic residue [active] 1121451004196 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 1121451004197 active site 1121451004198 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 1121451004199 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 1121451004200 Sulfate transporter family; Region: Sulfate_transp; pfam00916 1121451004201 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 1121451004202 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1121451004203 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1121451004204 substrate binding pocket [chemical binding]; other site 1121451004205 membrane-bound complex binding site; other site 1121451004206 hinge residues; other site 1121451004207 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1121451004208 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1121451004209 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1121451004210 active site 1121451004211 AMP binding site [chemical binding]; other site 1121451004212 acyl-activating enzyme (AAE) consensus motif; other site 1121451004213 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1121451004214 CoA binding site [chemical binding]; other site 1121451004215 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 1121451004216 active site 1121451004217 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1121451004218 3-oxoacyl-acyl carrier protein synthase; Provisional; Region: PTZ00050 1121451004219 dimer interface [polypeptide binding]; other site 1121451004220 active site 1121451004221 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1121451004222 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 1121451004223 putative acyl-acceptor binding pocket; other site 1121451004224 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 1121451004225 Ligand binding site; other site 1121451004226 Putative Catalytic site; other site 1121451004227 DXD motif; other site 1121451004228 Uncharacterized protein conserved in bacteria (DUF2062); Region: DUF2062; pfam09835 1121451004229 lipid biosynthesis B12-binding/radical SAM protein; Region: rSAM_ladder_B12; TIGR04072 1121451004230 Fe-S oxidoreductase [Energy production and conversion]; Region: COG1032 1121451004231 B12 binding site [chemical binding]; other site 1121451004232 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377 1121451004233 FeS/SAM binding site; other site 1121451004234 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1121451004235 active site 1121451004236 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1121451004237 active site 2 [active] 1121451004238 active site 1 [active] 1121451004239 Predicted exporter [General function prediction only]; Region: COG4258 1121451004240 Sterol-sensing domain of SREBP cleavage-activation; Region: Sterol-sensing; pfam12349 1121451004241 lipoprotein chaperone; Reviewed; Region: lolA; PRK00031 1121451004242 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl17548 1121451004243 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1121451004244 active site 2 [active] 1121451004245 active site 1 [active] 1121451004246 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1121451004247 putative heme d1 biosynthesis radical SAM protein NirJ2; Region: rSAM_NirJ2; TIGR04055 1121451004248 FeS/SAM binding site; other site 1121451004249 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 1121451004250 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1121451004251 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1121451004252 putative acyl-acceptor binding pocket; other site 1121451004253 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1121451004254 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK09116 1121451004255 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1121451004256 dimer interface [polypeptide binding]; other site 1121451004257 active site 1121451004258 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 1121451004259 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1121451004260 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 1121451004261 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1121451004262 dimer interface [polypeptide binding]; other site 1121451004263 active site 1121451004264 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1121451004265 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 1121451004266 NAD(P) binding site [chemical binding]; other site 1121451004267 homotetramer interface [polypeptide binding]; other site 1121451004268 homodimer interface [polypeptide binding]; other site 1121451004269 active site 1121451004270 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1121451004271 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1121451004272 PAS fold; Region: PAS_3; pfam08447 1121451004273 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1121451004274 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1121451004275 metal binding site [ion binding]; metal-binding site 1121451004276 active site 1121451004277 I-site; other site 1121451004278 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1121451004279 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1121451004280 putative active site [active] 1121451004281 heme pocket [chemical binding]; other site 1121451004282 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1121451004283 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1121451004284 putative active site [active] 1121451004285 heme pocket [chemical binding]; other site 1121451004286 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1121451004287 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1121451004288 putative active site [active] 1121451004289 heme pocket [chemical binding]; other site 1121451004290 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1121451004291 putative active site [active] 1121451004292 heme pocket [chemical binding]; other site 1121451004293 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1121451004294 dimer interface [polypeptide binding]; other site 1121451004295 phosphorylation site [posttranslational modification] 1121451004296 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1121451004297 ATP binding site [chemical binding]; other site 1121451004298 Mg2+ binding site [ion binding]; other site 1121451004299 G-X-G motif; other site 1121451004300 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1121451004301 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121451004302 active site 1121451004303 phosphorylation site [posttranslational modification] 1121451004304 intermolecular recognition site; other site 1121451004305 dimerization interface [polypeptide binding]; other site 1121451004306 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1121451004307 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1121451004308 HlyD family secretion protein; Region: HlyD_3; pfam13437 1121451004309 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 1121451004310 Suppressor of fused protein (SUFU); Region: SUFU; pfam05076 1121451004311 Protein export membrane protein; Region: SecD_SecF; cl14618 1121451004312 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 1121451004313 NeuB family; Region: NeuB; pfam03102 1121451004314 N-terminal domain of RfaE; Region: RfaE_N; cd02172 1121451004315 putative active site [active] 1121451004316 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 1121451004317 (T/H)XGH motif; other site 1121451004318 RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172 1121451004319 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1121451004320 putative ribose interaction site [chemical binding]; other site 1121451004321 putative ADP binding site [chemical binding]; other site 1121451004322 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 1121451004323 active site 1121451004324 dimer interface [polypeptide binding]; other site 1121451004325 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1121451004326 Radical SAM superfamily; Region: Radical_SAM; pfam04055 1121451004327 FeS/SAM binding site; other site 1121451004328 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 1121451004329 Phosphotransferase enzyme family; Region: APH; pfam01636 1121451004330 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1121451004331 active site 1121451004332 ATP binding site [chemical binding]; other site 1121451004333 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1121451004334 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 1121451004335 TPP-binding site [chemical binding]; other site 1121451004336 dimer interface [polypeptide binding]; other site 1121451004337 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 1121451004338 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1121451004339 PYR/PP interface [polypeptide binding]; other site 1121451004340 dimer interface [polypeptide binding]; other site 1121451004341 TPP binding site [chemical binding]; other site 1121451004342 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1121451004343 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1121451004344 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1121451004345 S-adenosylmethionine binding site [chemical binding]; other site 1121451004346 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535 1121451004347 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1121451004348 FeS/SAM binding site; other site 1121451004349 CMP-NeuAc_Synthase activates N-acetylneuraminic acid by adding CMP moiety; Region: CMP-NeuAc_Synthase; cd02513 1121451004350 ligand binding site; other site 1121451004351 tetramer interface; other site 1121451004352 N-acetylneuraminate synthase; Region: NeuB_NnaB; TIGR03569 1121451004353 NeuB family; Region: NeuB; pfam03102 1121451004354 C-terminal SAF domain of sialic acid synthetase; Region: SAF_NeuB_like; cd11615 1121451004355 NeuB binding interface [polypeptide binding]; other site 1121451004356 putative substrate binding site [chemical binding]; other site 1121451004357 UDP-N-acetyl-D-glucosamine 2-epimerase, UDP-hydrolysing; Region: NeuC_NnaA; TIGR03568 1121451004358 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 1121451004359 active site 1121451004360 homodimer interface [polypeptide binding]; other site 1121451004361 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1121451004362 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1121451004363 active site 1121451004364 metal binding site [ion binding]; metal-binding site 1121451004365 LuxQ, periplasmic; Region: LuxQ-periplasm; pfam09308 1121451004366 HAMP domain; Region: HAMP; pfam00672 1121451004367 PAS domain S-box; Region: sensory_box; TIGR00229 1121451004368 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1121451004369 putative active site [active] 1121451004370 heme pocket [chemical binding]; other site 1121451004371 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1121451004372 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1121451004373 putative active site [active] 1121451004374 heme pocket [chemical binding]; other site 1121451004375 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1121451004376 dimer interface [polypeptide binding]; other site 1121451004377 phosphorylation site [posttranslational modification] 1121451004378 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1121451004379 ATP binding site [chemical binding]; other site 1121451004380 Mg2+ binding site [ion binding]; other site 1121451004381 G-X-G motif; other site 1121451004382 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1121451004383 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 1121451004384 Uncharacterized member of the PurR regulon [General function prediction only]; Region: yhhQ; COG1738 1121451004385 7-cyano-7-deazaguanine reductase; Provisional; Region: PRK13258 1121451004386 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1121451004387 dimerization interface [polypeptide binding]; other site 1121451004388 putative DNA binding site [nucleotide binding]; other site 1121451004389 putative Zn2+ binding site [ion binding]; other site 1121451004390 Predicted permeases [General function prediction only]; Region: COG0701 1121451004391 DGC domain; Region: DGC; pfam08859 1121451004392 Response regulator receiver domain; Region: Response_reg; pfam00072 1121451004393 Response regulator receiver domain; Region: Response_reg; pfam00072 1121451004394 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121451004395 active site 1121451004396 phosphorylation site [posttranslational modification] 1121451004397 intermolecular recognition site; other site 1121451004398 dimerization interface [polypeptide binding]; other site 1121451004399 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1121451004400 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1121451004401 metal binding site [ion binding]; metal-binding site 1121451004402 active site 1121451004403 I-site; other site 1121451004404 Late competence development protein ComFB; Region: ComFB; pfam10719 1121451004405 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1121451004406 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1121451004407 HlyD family secretion protein; Region: HlyD_3; pfam13437 1121451004408 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 1121451004409 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 1121451004410 PAS domain; Region: PAS_9; pfam13426 1121451004411 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1121451004412 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1121451004413 ATP binding site [chemical binding]; other site 1121451004414 Mg2+ binding site [ion binding]; other site 1121451004415 G-X-G motif; other site 1121451004416 META domain; Region: META; pfam03724 1121451004417 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 1121451004418 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 1121451004419 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1121451004420 Domain of unknown function (DUF3391); Region: DUF3391; pfam11871 1121451004421 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 1121451004422 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1121451004423 Zn2+ binding site [ion binding]; other site 1121451004424 Mg2+ binding site [ion binding]; other site 1121451004425 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319 1121451004426 active site 1121451004427 4Fe-4S binding domain; Region: Fer4; pfam00037 1121451004428 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 1121451004429 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1121451004430 phosphate binding site [ion binding]; other site 1121451004431 GXGXG domain. This domain of unknown function is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS), in subunit C of tungsten formylmethanofuran dehydrogenase (FwdC) and in subunit C of molybdenum formylmethanofuran...; Region: GXGXG; cl00239 1121451004432 domain_subunit interface; other site 1121451004433 putative glutamate synthase (NADPH) small subunit; Provisional; Region: PRK12771 1121451004434 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1121451004435 4Fe-4S binding domain; Region: Fer4; pfam00037 1121451004436 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1121451004437 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1121451004438 active site 1121451004439 Bacterial OB fold (BOF) protein; Region: BOF; cl01196 1121451004440 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1121451004441 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1121451004442 dimerization interface [polypeptide binding]; other site 1121451004443 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1121451004444 dimer interface [polypeptide binding]; other site 1121451004445 phosphorylation site [posttranslational modification] 1121451004446 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1121451004447 ATP binding site [chemical binding]; other site 1121451004448 Mg2+ binding site [ion binding]; other site 1121451004449 G-X-G motif; other site 1121451004450 Response regulator receiver domain; Region: Response_reg; pfam00072 1121451004451 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121451004452 active site 1121451004453 phosphorylation site [posttranslational modification] 1121451004454 intermolecular recognition site; other site 1121451004455 dimerization interface [polypeptide binding]; other site 1121451004456 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 1121451004457 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 1121451004458 ligand binding site [chemical binding]; other site 1121451004459 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1121451004460 EamA-like transporter family; Region: EamA; pfam00892 1121451004461 EamA-like transporter family; Region: EamA; pfam00892 1121451004462 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1121451004463 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1121451004464 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1121451004465 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1121451004466 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1121451004467 DNA binding site [nucleotide binding] 1121451004468 active site 1121451004469 HDOD domain; Region: HDOD; pfam08668 1121451004470 GAF domain; Region: GAF_3; pfam13492 1121451004471 PAS domain; Region: PAS; smart00091 1121451004472 PAS domain; Region: PAS_9; pfam13426 1121451004473 putative active site [active] 1121451004474 heme pocket [chemical binding]; other site 1121451004475 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1121451004476 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1121451004477 dimer interface [polypeptide binding]; other site 1121451004478 phosphorylation site [posttranslational modification] 1121451004479 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1121451004480 ATP binding site [chemical binding]; other site 1121451004481 Mg2+ binding site [ion binding]; other site 1121451004482 G-X-G motif; other site 1121451004483 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 1121451004484 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 1121451004485 PhnA protein; Region: PhnA; pfam03831 1121451004486 DhnA-type fructose-1,6-bisphosphate aldolase and related enzymes [Carbohydrate transport and metabolism]; Region: FbaB; COG1830 1121451004487 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 1121451004488 putative active site; other site 1121451004489 catalytic residue [active] 1121451004490 tRNA and rRNA cytosine-C5-methylases [Translation, ribosomal structure and biogenesis]; Region: Sun; COG0144 1121451004491 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1121451004492 S-adenosylmethionine binding site [chemical binding]; other site 1121451004493 Family description; Region: VCBS; pfam13517 1121451004494 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 1121451004495 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 1121451004496 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290 1121451004497 DctM-like transporters; Region: DctM; pfam06808 1121451004498 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 1121451004499 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1121451004500 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1121451004501 RNA binding surface [nucleotide binding]; other site 1121451004502 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1121451004503 active site 1121451004504 Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I) [Energy production and conversion]; Region: NuoI; COG1143 1121451004505 NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338 1121451004506 Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261 1121451004507 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl16917 1121451004508 Ni,Fe-hydrogenase III small subunit [Energy production and conversion]; Region: COG3260 1121451004509 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 1121451004510 NADH dehydrogenase; Region: NADHdh; cl00469 1121451004511 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12667 1121451004512 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1121451004513 Orthopoxvirus protein of unknown function (DUF830); Region: DUF830; cl13998 1121451004514 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1121451004515 NlpC/P60 family; Region: NLPC_P60; pfam00877 1121451004516 putative regulatory protein, FmdB family; Region: CxxC_CxxC_SSSS; TIGR02605 1121451004517 adenylosuccinate lyase; Provisional; Region: PRK07492 1121451004518 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 1121451004519 tetramer interface [polypeptide binding]; other site 1121451004520 active site 1121451004521 Adenylosuccinate lyase C-terminus; Region: ADSL_C; smart00998 1121451004522 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1121451004523 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3034 1121451004524 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 1121451004525 active site 1121451004526 Zn binding site [ion binding]; other site 1121451004527 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 1121451004528 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 1121451004529 Metal-binding active site; metal-binding site 1121451004530 DctM-like transporters; Region: DctM; pfam06808 1121451004531 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274 1121451004532 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290 1121451004533 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 1121451004534 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 1121451004535 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 1121451004536 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 1121451004537 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 1121451004538 Hydantoinase B/oxoprolinase; Region: Hydantoinase_B; pfam02538 1121451004539 Branched-chain amino acid transport protein (AzlD); Region: AzlD; cl00735 1121451004540 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 1121451004541 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1121451004542 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1121451004543 DNA-binding site [nucleotide binding]; DNA binding site 1121451004544 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1121451004545 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1121451004546 homodimer interface [polypeptide binding]; other site 1121451004547 catalytic residue [active] 1121451004548 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1121451004549 binding surface 1121451004550 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1121451004551 TPR motif; other site 1121451004552 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 1121451004553 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 1121451004554 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 1121451004555 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 1121451004556 RNA binding site [nucleotide binding]; other site 1121451004557 Response regulator receiver domain; Region: Response_reg; pfam00072 1121451004558 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121451004559 active site 1121451004560 phosphorylation site [posttranslational modification] 1121451004561 intermolecular recognition site; other site 1121451004562 dimerization interface [polypeptide binding]; other site 1121451004563 3D domain; Region: 3D; cl01439 1121451004564 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1121451004565 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1121451004566 Walker A/P-loop; other site 1121451004567 ATP binding site [chemical binding]; other site 1121451004568 Q-loop/lid; other site 1121451004569 ABC transporter signature motif; other site 1121451004570 Walker B; other site 1121451004571 D-loop; other site 1121451004572 H-loop/switch region; other site 1121451004573 cobalt ABC transporter, permease protein CbiQ; Region: CbiQ_TIGR; TIGR02454 1121451004574 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1121451004575 S-adenosylmethionine binding site [chemical binding]; other site 1121451004576 Shikimate kinase; Region: SKI; pfam01202 1121451004577 Amidinotransferase; Region: Amidinotransf; cl12043 1121451004578 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 1121451004579 Ligand binding site; other site 1121451004580 DXD motif; other site 1121451004581 Putative Catalytic site; other site 1121451004582 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 1121451004583 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1121451004584 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1121451004585 TPR motif; other site 1121451004586 binding surface 1121451004587 TPR repeat; Region: TPR_11; pfam13414 1121451004588 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1121451004589 TPR repeat; Region: TPR_11; pfam13414 1121451004590 binding surface 1121451004591 TPR motif; other site 1121451004592 Protein of unknown function (DUF401); Region: DUF401; cl00830 1121451004593 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 1121451004594 substrate binding site [chemical binding]; other site 1121451004595 Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437 1121451004596 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121451004597 active site 1121451004598 phosphorylation site [posttranslational modification] 1121451004599 intermolecular recognition site; other site 1121451004600 dimerization interface [polypeptide binding]; other site 1121451004601 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1121451004602 Zn2+ binding site [ion binding]; other site 1121451004603 Mg2+ binding site [ion binding]; other site 1121451004604 4Fe-4S binding domain; Region: Fer4; pfam00037 1121451004605 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 1121451004606 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1121451004607 anti sigma factor interaction site; other site 1121451004608 regulatory phosphorylation site [posttranslational modification]; other site 1121451004609 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 1121451004610 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1121451004611 multifunctional aminopeptidase A; Provisional; Region: PRK00913 1121451004612 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 1121451004613 interface (dimer of trimers) [polypeptide binding]; other site 1121451004614 Substrate-binding/catalytic site; other site 1121451004615 Zn-binding sites [ion binding]; other site 1121451004616 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 1121451004617 active site 1121451004618 homotetramer interface [polypeptide binding]; other site 1121451004619 homodimer interface [polypeptide binding]; other site 1121451004620 PAS domain; Region: PAS_9; pfam13426 1121451004621 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1121451004622 putative active site [active] 1121451004623 heme pocket [chemical binding]; other site 1121451004624 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1121451004625 PAS fold; Region: PAS_3; pfam08447 1121451004626 putative active site [active] 1121451004627 heme pocket [chemical binding]; other site 1121451004628 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1121451004629 dimer interface [polypeptide binding]; other site 1121451004630 phosphorylation site [posttranslational modification] 1121451004631 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1121451004632 ATP binding site [chemical binding]; other site 1121451004633 Mg2+ binding site [ion binding]; other site 1121451004634 G-X-G motif; other site 1121451004635 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 1121451004636 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 1121451004637 G1 box; other site 1121451004638 putative GEF interaction site [polypeptide binding]; other site 1121451004639 GTP/Mg2+ binding site [chemical binding]; other site 1121451004640 Switch I region; other site 1121451004641 G2 box; other site 1121451004642 G3 box; other site 1121451004643 Switch II region; other site 1121451004644 G4 box; other site 1121451004645 G5 box; other site 1121451004646 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 1121451004647 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 1121451004648 FAD-dependent thymidylate synthase; Reviewed; Region: thyX; PRK00847 1121451004649 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 1121451004650 DnaA N-terminal domain; Region: DnaA_N; pfam11638 1121451004651 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1121451004652 Walker A motif; other site 1121451004653 ATP binding site [chemical binding]; other site 1121451004654 Walker B motif; other site 1121451004655 arginine finger; other site 1121451004656 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 1121451004657 DnaA box-binding interface [nucleotide binding]; other site 1121451004658 DnaA N-terminal domain; Region: DnaA_N; pfam11638 1121451004659 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 1121451004660 PIN domain; Region: PIN_Smg5-Smg6-like; cd09880 1121451004661 putative active site [active] 1121451004662 PhoH-like protein; Region: PhoH; cl17668 1121451004663 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 1121451004664 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 1121451004665 dimer interface [polypeptide binding]; other site 1121451004666 putative functional site; other site 1121451004667 putative MPT binding site; other site 1121451004668 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 1121451004669 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 1121451004670 GTP binding site; other site 1121451004671 Peptidase family C54; Region: Peptidase_C54; pfam03416 1121451004672 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1121451004673 acetyl coenzyme A synthetase (ADP forming), alpha domain; Region: AcCoA-syn-alpha; TIGR02717 1121451004674 CoA binding domain; Region: CoA_binding_2; pfam13380 1121451004675 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 1121451004676 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 1121451004677 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 1121451004678 BioD-like N-terminal domain of phosphotransacetylase [General function prediction only]; Region: Pta; COG0857 1121451004679 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1121451004680 DRTGG domain; Region: DRTGG; pfam07085 1121451004681 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 1121451004682 Cysteine-rich domain; Region: CCG; pfam02754 1121451004683 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168 1121451004684 heme-binding residues [chemical binding]; other site 1121451004685 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1121451004686 active site 1121451004687 GTP-binding protein YchF; Reviewed; Region: PRK09601 1121451004688 YchF GTPase; Region: YchF; cd01900 1121451004689 G1 box; other site 1121451004690 GTP/Mg2+ binding site [chemical binding]; other site 1121451004691 Switch I region; other site 1121451004692 G2 box; other site 1121451004693 Switch II region; other site 1121451004694 G3 box; other site 1121451004695 G4 box; other site 1121451004696 G5 box; other site 1121451004697 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 1121451004698 Domain of unknown function (DUF697); Region: DUF697; cl12064 1121451004699 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 1121451004700 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 1121451004701 Phosphocholine cytidylyltransferases catalyze the synthesis of CDP-choline; Region: PC_cytidylyltransferase; cd02523 1121451004702 active site 1121451004703 metal-binding site 1121451004704 CMP-NeuAc_Synthase activates N-acetylneuraminic acid by adding CMP moiety; Region: CMP-NeuAc_Synthase; cd02513 1121451004705 ligand binding site; other site 1121451004706 tetramer interface; other site 1121451004707 Spore coat polysaccharide biosynthesis protein, predicted glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: spsG; COG3980 1121451004708 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1121451004709 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1121451004710 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1121451004711 S-adenosylmethionine binding site [chemical binding]; other site 1121451004712 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4627 1121451004713 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 1121451004714 Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465 1121451004715 active site 1121451004716 NAD binding site [chemical binding]; other site 1121451004717 metal binding site [ion binding]; metal-binding site 1121451004718 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 1121451004719 PYR/PP interface [polypeptide binding]; other site 1121451004720 dimer interface [polypeptide binding]; other site 1121451004721 TPP binding site [chemical binding]; other site 1121451004722 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 1121451004723 TPP-binding site [chemical binding]; other site 1121451004724 Sialic acid synthase [Cell envelope biogenesis, outer membrane]; Region: SpsE; COG2089 1121451004725 NeuB family; Region: NeuB; pfam03102 1121451004726 C-terminal SAF domain of sialic acid synthetase; Region: SAF_NeuB_like; cd11615 1121451004727 putative substrate binding site [chemical binding]; other site 1121451004728 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1121451004729 active site 1121451004730 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1121451004731 S-adenosylmethionine binding site [chemical binding]; other site 1121451004732 Predicted ATP-dependent carboligase related to biotin carboxylase [General function prediction only]; Region: COG2232 1121451004733 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 1121451004734 N-terminal catalytic domain of alpha-galactosidase; glycoside hydrolase family 57 (GH57); Region: GH57N_PfGalA_like; cd10794 1121451004735 putative active site [active] 1121451004736 catalytic site [active] 1121451004737 UDP-N-acetylglucosamine 4,6-dehydratase; Region: PseB; TIGR03589 1121451004738 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 1121451004739 NAD(P) binding site [chemical binding]; other site 1121451004740 homodimer interface [polypeptide binding]; other site 1121451004741 substrate binding site [chemical binding]; other site 1121451004742 active site 1121451004743 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 1121451004744 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 1121451004745 inhibitor-cofactor binding pocket; inhibition site 1121451004746 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1121451004747 catalytic residue [active] 1121451004748 BNR repeat-like domain; Region: BNR_2; pfam13088 1121451004749 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cl17698 1121451004750 Asp-box motif; other site 1121451004751 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1121451004752 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 1121451004753 NAD(P) binding site [chemical binding]; other site 1121451004754 active site 1121451004755 HI0933-like protein; Region: HI0933_like; pfam03486 1121451004756 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1121451004757 Response regulator receiver domain; Region: Response_reg; pfam00072 1121451004758 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121451004759 active site 1121451004760 phosphorylation site [posttranslational modification] 1121451004761 intermolecular recognition site; other site 1121451004762 dimerization interface [polypeptide binding]; other site 1121451004763 cytochrome-c3 hydrogenase subunit gamma; Provisional; Region: PRK08345 1121451004764 Anaerobic sulfite reductase contains an FAD and NADPH binding module with structural similarity to ferredoxin reductase and sequence similarity to dihydroorotate dehydrogenases. Clostridium pasteurianum inducible dissimilatory type sulfite reductase is...; Region: sulfite_reductase_like; cd06221 1121451004765 FAD binding pocket [chemical binding]; other site 1121451004766 FAD binding motif [chemical binding]; other site 1121451004767 phosphate binding motif [ion binding]; other site 1121451004768 beta-alpha-beta structure motif; other site 1121451004769 NAD binding pocket [chemical binding]; other site 1121451004770 Iron coordination center [ion binding]; other site 1121451004771 anaerobic sulfite reductase subunit A; Provisional; Region: PRK15055 1121451004772 Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus; Region: FrhB_FdhB_C; pfam04432 1121451004773 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 1121451004774 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1121451004775 Methyl-viologen-reducing hydrogenase, delta subunit; Region: FlpD; pfam02662 1121451004776 Heterodisulfide reductase, subunit A and related polyferredoxins [Energy production and conversion]; Region: HdrA; COG1148 1121451004777 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1121451004778 Heterodisulfide reductase, subunit B [Energy production and conversion]; Region: HdrB; COG2048 1121451004779 Cysteine-rich domain; Region: CCG; pfam02754 1121451004780 Cysteine-rich domain; Region: CCG; pfam02754 1121451004781 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1121451004782 4Fe-4S dicluster domain; Region: Fer4_17; pfam13534 1121451004783 Cytochrome c554 and c-prime; Region: Cytochrome_C554; pfam13435 1121451004784 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1121451004785 dimerization interface [polypeptide binding]; other site 1121451004786 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1121451004787 PAS domain; Region: PAS_9; pfam13426 1121451004788 putative active site [active] 1121451004789 heme pocket [chemical binding]; other site 1121451004790 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1121451004791 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1121451004792 dimer interface [polypeptide binding]; other site 1121451004793 putative CheW interface [polypeptide binding]; other site 1121451004794 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 1121451004795 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1121451004796 ligand binding site [chemical binding]; other site 1121451004797 L-cysteine desulfidase [Amino acid transport and metabolism]; Region: COG3681 1121451004798 ADP-L-glycero-D-mannoheptose 6-epimerase (GME), extended (e) SDRs; Region: ADP_GME_SDR_e; cd05248 1121451004799 ADP-L-glycero-D-manno-heptose-6-epimerase; Region: heptose_epim; TIGR02197 1121451004800 NADP binding site [chemical binding]; other site 1121451004801 homopentamer interface [polypeptide binding]; other site 1121451004802 substrate binding site [chemical binding]; other site 1121451004803 active site 1121451004804 Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452 1121451004805 Organic solvent tolerance protein; Region: OstA_C; pfam04453 1121451004806 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 1121451004807 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1121451004808 ATP binding site [chemical binding]; other site 1121451004809 Mg2+ binding site [ion binding]; other site 1121451004810 G-X-G motif; other site 1121451004811 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 1121451004812 ATP binding site [chemical binding]; other site 1121451004813 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 1121451004814 Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787 1121451004815 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 1121451004816 active site 1121451004817 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1121451004818 dimer interface [polypeptide binding]; other site 1121451004819 substrate binding site [chemical binding]; other site 1121451004820 catalytic residues [active] 1121451004821 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 1121451004822 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1121451004823 Integrase core domain; Region: rve_3; pfam13683 1121451004824 Transposase; Region: HTH_Tnp_1; cl17663 1121451004825 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1121451004826 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1121451004827 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 1121451004828 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 1121451004829 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1121451004830 DNA binding residues [nucleotide binding] 1121451004831 drug binding residues [chemical binding]; other site 1121451004832 dimer interface [polypeptide binding]; other site 1121451004833 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 1121451004834 Multidrug resistance efflux transporter; Region: EmrE; pfam13536 1121451004835 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 1121451004836 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 1121451004837 Hexamer interface [polypeptide binding]; other site 1121451004838 Hexagonal pore residue; other site 1121451004839 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 1121451004840 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 1121451004841 Hexamer interface [polypeptide binding]; other site 1121451004842 Hexagonal pore residue; other site 1121451004843 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 1121451004844 putative catalytic cysteine [active] 1121451004845 Pyruvate formate lyase 2 and related enzymes; Region: PFL2_DhaB_BssA; cd01677 1121451004846 glycyl radical enzyme, PFL2/glycerol dehydratase family; Region: PFL2-3; TIGR01774 1121451004847 dimer interface [polypeptide binding]; other site 1121451004848 active site 1121451004849 glycine loop; other site 1121451004850 glycyl-radical enzyme activating protein family; Region: PFLE_PFLC; TIGR02494 1121451004851 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 1121451004852 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 1121451004853 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 1121451004854 Hexamer interface [polypeptide binding]; other site 1121451004855 Hexagonal pore residue; other site 1121451004856 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 1121451004857 putative catalytic cysteine [active] 1121451004858 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 1121451004859 1,2-propanediol utilization protein A (PduA), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduA; cd07059 1121451004860 Hexamer interface [polypeptide binding]; other site 1121451004861 Putative hexagonal pore residue; other site 1121451004862 propanediol utilization phosphotransacylase; Provisional; Region: PRK15070 1121451004863 Propanediol utilisation protein PduL; Region: PduL; pfam06130 1121451004864 Propanediol utilisation protein PduL; Region: PduL; pfam06130 1121451004865 ethanolamine utilization protein EutJ; Provisional; Region: PRK15080 1121451004866 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1121451004867 nucleotide binding site [chemical binding]; other site 1121451004868 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1121451004869 ethanolamine utilization protein; Region: eut_hyp; TIGR02536 1121451004870 Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614 1121451004871 Hexamer/Pentamer interface [polypeptide binding]; other site 1121451004872 central pore; other site 1121451004873 PduT-like ethanolamine utilization protein; Region: eut_PduT; TIGR02526 1121451004874 1,2-propanediol utilization protein T (PduT), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_PduT_repeat1; cd07053 1121451004875 putative hexamer interface [polypeptide binding]; other site 1121451004876 putative hexagonal pore; other site 1121451004877 1,2-propanediol utilization protein T (PduT), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_PduT_repeat2; cd07054 1121451004878 putative hexamer interface [polypeptide binding]; other site 1121451004879 putative hexagonal pore; other site 1121451004880 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 1121451004881 1,2-propanediol utilization protein A (PduA), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduA; cd07059 1121451004882 Hexamer interface [polypeptide binding]; other site 1121451004883 Putative hexagonal pore residue; other site 1121451004884 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 1121451004885 1,3-propanediol dehydrogenase (PPD) catalyzes the reduction of 3-hydroxypropionaldehyde (3-HPA) to 1,3-propanediol in glycerol metabolism; Region: PDD; cd08180 1121451004886 putative active site [active] 1121451004887 metal binding site [ion binding]; metal-binding site 1121451004888 Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512 1121451004889 SLBB domain; Region: SLBB; pfam10531 1121451004890 4Fe-4S dicluster domain; Region: Fer4_17; pfam13534 1121451004891 RnfC Barrel sandwich hybrid domain; Region: RnfC_N; pfam13375 1121451004892 PduT-like ethanolamine utilization protein; Region: eut_PduT; TIGR02526 1121451004893 1,2-propanediol utilization protein T (PduT), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_PduT_repeat1; cd07053 1121451004894 putative hexamer interface [polypeptide binding]; other site 1121451004895 putative hexagonal pore; other site 1121451004896 1,2-propanediol utilization protein T (PduT), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_PduT_repeat2; cd07054 1121451004897 putative hexamer interface [polypeptide binding]; other site 1121451004898 putative hexagonal pore; other site 1121451004899 1,2-propanediol utilization protein U (PduU)/ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduU-EutS; cd07046 1121451004900 putative hexamer interface [polypeptide binding]; other site 1121451004901 putative hexagonal pore; other site 1121451004902 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 1121451004903 G1 box; other site 1121451004904 GTP/Mg2+ binding site [chemical binding]; other site 1121451004905 Switch I region; other site 1121451004906 G3 box; other site 1121451004907 Switch II region; other site 1121451004908 G4 box; other site 1121451004909 G5 box; other site 1121451004910 Cache domain; Region: Cache_1; pfam02743 1121451004911 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 1121451004912 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1121451004913 dimerization interface [polypeptide binding]; other site 1121451004914 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 1121451004915 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 1121451004916 Outer membrane efflux protein; Region: OEP; pfam02321 1121451004917 Outer membrane efflux protein; Region: OEP; pfam02321 1121451004918 Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999 1121451004919 HlyD family secretion protein; Region: HlyD_3; pfam13437 1121451004920 Protein of unknown function (DUF3347); Region: DUF3347; pfam11827 1121451004921 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 1121451004922 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 1121451004923 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 1121451004924 Ribonucleotide reductase, barrel domain; Region: Ribonuc_red_lgC; pfam02867 1121451004925 TSCPD domain; Region: TSCPD; cl14834 1121451004926 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1121451004927 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1121451004928 putative DNA binding site [nucleotide binding]; other site 1121451004929 putative Zn2+ binding site [ion binding]; other site 1121451004930 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1121451004931 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1121451004932 S-adenosylmethionine binding site [chemical binding]; other site 1121451004933 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1121451004934 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1121451004935 metal binding site [ion binding]; metal-binding site 1121451004936 active site 1121451004937 I-site; other site 1121451004938 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1121451004939 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1121451004940 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1121451004941 ATP binding site [chemical binding]; other site 1121451004942 Mg2+ binding site [ion binding]; other site 1121451004943 G-X-G motif; other site 1121451004944 Protein of unknown function (DUF3478); Region: DUF3478; pfam11964 1121451004945 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 1121451004946 Domain of unknown function (DUF3412); Region: DUF3412; pfam11892 1121451004947 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 1121451004948 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 1121451004949 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1121451004950 dimerization interface [polypeptide binding]; other site 1121451004951 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1121451004952 dimer interface [polypeptide binding]; other site 1121451004953 putative CheW interface [polypeptide binding]; other site 1121451004954 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 1121451004955 putative CheA interaction surface; other site 1121451004956 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1121451004957 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1121451004958 PAS domain; Region: PAS_9; pfam13426 1121451004959 putative active site [active] 1121451004960 heme pocket [chemical binding]; other site 1121451004961 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1121451004962 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1121451004963 dimer interface [polypeptide binding]; other site 1121451004964 phosphorylation site [posttranslational modification] 1121451004965 Response regulator receiver domain; Region: Response_reg; pfam00072 1121451004966 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121451004967 active site 1121451004968 phosphorylation site [posttranslational modification] 1121451004969 intermolecular recognition site; other site 1121451004970 dimerization interface [polypeptide binding]; other site 1121451004971 MarC family integral membrane protein; Region: MarC; cl00919 1121451004972 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 1121451004973 intersubunit interface [polypeptide binding]; other site 1121451004974 active site 1121451004975 Zn2+ binding site [ion binding]; other site 1121451004976 Peptidase family M48; Region: Peptidase_M48; pfam01435 1121451004977 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1121451004978 binding surface 1121451004979 TPR motif; other site 1121451004980 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 1121451004981 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 1121451004982 ring oligomerisation interface [polypeptide binding]; other site 1121451004983 ATP/Mg binding site [chemical binding]; other site 1121451004984 stacking interactions; other site 1121451004985 hinge regions; other site 1121451004986 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 1121451004987 oligomerisation interface [polypeptide binding]; other site 1121451004988 mobile loop; other site 1121451004989 roof hairpin; other site 1121451004990 Predicted transcriptional regulator [Transcription]; Region: COG2932 1121451004991 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1121451004992 Catalytic site [active] 1121451004993 Homeodomain-like domain; Region: HTH_23; pfam13384 1121451004994 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1121451004995 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1121451004996 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1121451004997 putative active site [active] 1121451004998 heme pocket [chemical binding]; other site 1121451004999 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1121451005000 putative active site [active] 1121451005001 heme pocket [chemical binding]; other site 1121451005002 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1121451005003 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1121451005004 metal binding site [ion binding]; metal-binding site 1121451005005 active site 1121451005006 I-site; other site 1121451005007 Predicted inhibitor of MCP methylation, homolog of CheC [Cell motility and secretion]; Region: COG1406 1121451005008 Chemotaxis phosphatase CheX; Region: CheX; pfam13690 1121451005009 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 1121451005010 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1121451005011 active site 1121451005012 HIGH motif; other site 1121451005013 nucleotide binding site [chemical binding]; other site 1121451005014 catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807 1121451005015 KMSKS motif; other site 1121451005016 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 1121451005017 [FeFe] hydrogenase H-cluster maturation GTPase HydF; Region: GTP_HydF; TIGR03918 1121451005018 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 1121451005019 G1 box; other site 1121451005020 GTP/Mg2+ binding site [chemical binding]; other site 1121451005021 G2 box; other site 1121451005022 Switch I region; other site 1121451005023 G3 box; other site 1121451005024 Switch II region; other site 1121451005025 G4 box; other site 1121451005026 G5 box; other site 1121451005027 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 1121451005028 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 1121451005029 ligand binding site [chemical binding]; other site 1121451005030 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1121451005031 dimerization interface [polypeptide binding]; other site 1121451005032 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1121451005033 dimer interface [polypeptide binding]; other site 1121451005034 phosphorylation site [posttranslational modification] 1121451005035 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1121451005036 ATP binding site [chemical binding]; other site 1121451005037 Mg2+ binding site [ion binding]; other site 1121451005038 G-X-G motif; other site 1121451005039 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1121451005040 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121451005041 active site 1121451005042 phosphorylation site [posttranslational modification] 1121451005043 intermolecular recognition site; other site 1121451005044 dimerization interface [polypeptide binding]; other site 1121451005045 Response regulator receiver domain; Region: Response_reg; pfam00072 1121451005046 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121451005047 active site 1121451005048 phosphorylation site [posttranslational modification] 1121451005049 intermolecular recognition site; other site 1121451005050 dimerization interface [polypeptide binding]; other site 1121451005051 Hpt domain; Region: Hpt; pfam01627 1121451005052 putative binding surface; other site 1121451005053 active site 1121451005054 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 1121451005055 Sodium Bile acid symporter family; Region: SBF; pfam01758 1121451005056 Flagellin N-methylase; Region: FliB; pfam03692 1121451005057 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 1121451005058 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 1121451005059 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1121451005060 catalytic residue [active] 1121451005061 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 1121451005062 active site 1121451005063 intersubunit interactions; other site 1121451005064 catalytic residue [active] 1121451005065 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 1121451005066 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 1121451005067 NMT1-like family; Region: NMT1_2; pfam13379 1121451005068 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1121451005069 dimerization interface [polypeptide binding]; other site 1121451005070 PAS domain S-box; Region: sensory_box; TIGR00229 1121451005071 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1121451005072 putative active site [active] 1121451005073 heme pocket [chemical binding]; other site 1121451005074 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 1121451005075 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1121451005076 putative active site [active] 1121451005077 heme pocket [chemical binding]; other site 1121451005078 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1121451005079 dimer interface [polypeptide binding]; other site 1121451005080 phosphorylation site [posttranslational modification] 1121451005081 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1121451005082 ATP binding site [chemical binding]; other site 1121451005083 Mg2+ binding site [ion binding]; other site 1121451005084 G-X-G motif; other site 1121451005085 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 1121451005086 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1121451005087 Walker A/P-loop; other site 1121451005088 ATP binding site [chemical binding]; other site 1121451005089 Q-loop/lid; other site 1121451005090 ABC transporter signature motif; other site 1121451005091 Walker B; other site 1121451005092 D-loop; other site 1121451005093 H-loop/switch region; other site 1121451005094 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 1121451005095 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 1121451005096 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1121451005097 Walker A/P-loop; other site 1121451005098 ATP binding site [chemical binding]; other site 1121451005099 Q-loop/lid; other site 1121451005100 ABC transporter signature motif; other site 1121451005101 Walker B; other site 1121451005102 D-loop; other site 1121451005103 H-loop/switch region; other site 1121451005104 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 1121451005105 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 1121451005106 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1121451005107 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1121451005108 dimer interface [polypeptide binding]; other site 1121451005109 conserved gate region; other site 1121451005110 putative PBP binding loops; other site 1121451005111 ABC-ATPase subunit interface; other site 1121451005112 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1121451005113 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1121451005114 dimer interface [polypeptide binding]; other site 1121451005115 conserved gate region; other site 1121451005116 putative PBP binding loops; other site 1121451005117 ABC-ATPase subunit interface; other site 1121451005118 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1121451005119 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_2; cd08498 1121451005120 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1121451005121 dimerization interface [polypeptide binding]; other site 1121451005122 nitrogen fixation negative regulator NifL; Region: nifL_nitrog; TIGR02938 1121451005123 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 1121451005124 putative active site [active] 1121451005125 heme pocket [chemical binding]; other site 1121451005126 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1121451005127 putative active site [active] 1121451005128 heme pocket [chemical binding]; other site 1121451005129 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1121451005130 dimer interface [polypeptide binding]; other site 1121451005131 phosphorylation site [posttranslational modification] 1121451005132 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1121451005133 ATP binding site [chemical binding]; other site 1121451005134 Mg2+ binding site [ion binding]; other site 1121451005135 G-X-G motif; other site 1121451005136 Transcriptional regulator; Region: Rrf2; cl17282 1121451005137 Rrf2 family protein; Region: rrf2_super; TIGR00738 1121451005138 Response regulator receiver domain; Region: Response_reg; pfam00072 1121451005139 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121451005140 active site 1121451005141 phosphorylation site [posttranslational modification] 1121451005142 intermolecular recognition site; other site 1121451005143 dimerization interface [polypeptide binding]; other site 1121451005144 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1121451005145 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1121451005146 ATP binding site [chemical binding]; other site 1121451005147 Mg2+ binding site [ion binding]; other site 1121451005148 G-X-G motif; other site 1121451005149 Response regulator receiver domain; Region: Response_reg; pfam00072 1121451005150 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121451005151 active site 1121451005152 phosphorylation site [posttranslational modification] 1121451005153 intermolecular recognition site; other site 1121451005154 dimerization interface [polypeptide binding]; other site 1121451005155 Response regulator receiver domain; Region: Response_reg; pfam00072 1121451005156 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121451005157 active site 1121451005158 phosphorylation site [posttranslational modification] 1121451005159 intermolecular recognition site; other site 1121451005160 dimerization interface [polypeptide binding]; other site 1121451005161 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1121451005162 Ligand Binding Site [chemical binding]; other site 1121451005163 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1121451005164 Ligand Binding Site [chemical binding]; other site 1121451005165 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 1121451005166 Polysulphide reductase [Energy production and conversion]; Region: COG5557; cl17901 1121451005167 Polysulphide reductase, NrfD; Region: NrfD; pfam03916 1121451005168 hydrogenase 2 protein HybA; Provisional; Region: PRK10882 1121451005169 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168 1121451005170 heme-binding residues [chemical binding]; other site 1121451005171 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168 1121451005172 heme-binding residues [chemical binding]; other site 1121451005173 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168 1121451005174 heme-binding residues [chemical binding]; other site 1121451005175 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168 1121451005176 heme-binding residues [chemical binding]; other site 1121451005177 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 1121451005178 nucleoside/Zn binding site; other site 1121451005179 dimer interface [polypeptide binding]; other site 1121451005180 catalytic motif [active] 1121451005181 Radical SAM superfamily; Region: Radical_SAM; pfam04055 1121451005182 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1121451005183 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1121451005184 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1121451005185 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 1121451005186 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1121451005187 active site 1121451005188 DNA binding site [nucleotide binding] 1121451005189 Int/Topo IB signature motif; other site 1121451005190 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 1121451005191 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1121451005192 This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798 1121451005193 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1121451005194 DNA polymerase II large subunit; Validated; Region: PRK04023 1121451005195 FOG: CBS domain [General function prediction only]; Region: COG0517 1121451005196 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_17; cd04630 1121451005197 Nitrogen regulatory protein P-II; Region: P-II; cl00412 1121451005198 Nitrogen regulatory protein P-II; Region: P-II; smart00938 1121451005199 Protein of unknown function (DUF1538); Region: DUF1538; pfam07556 1121451005200 Protein of unknown function (DUF1538); Region: DUF1538; pfam07556 1121451005201 Response regulator receiver domain; Region: Response_reg; pfam00072 1121451005202 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121451005203 active site 1121451005204 phosphorylation site [posttranslational modification] 1121451005205 intermolecular recognition site; other site 1121451005206 dimerization interface [polypeptide binding]; other site 1121451005207 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1121451005208 dimer interface [polypeptide binding]; other site 1121451005209 phosphorylation site [posttranslational modification] 1121451005210 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1121451005211 ATP binding site [chemical binding]; other site 1121451005212 Mg2+ binding site [ion binding]; other site 1121451005213 G-X-G motif; other site 1121451005214 Response regulator receiver domain; Region: Response_reg; pfam00072 1121451005215 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121451005216 active site 1121451005217 phosphorylation site [posttranslational modification] 1121451005218 intermolecular recognition site; other site 1121451005219 dimerization interface [polypeptide binding]; other site 1121451005220 Response regulator receiver domain; Region: Response_reg; pfam00072 1121451005221 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121451005222 active site 1121451005223 phosphorylation site [posttranslational modification] 1121451005224 intermolecular recognition site; other site 1121451005225 dimerization interface [polypeptide binding]; other site 1121451005226 Response regulator receiver domain; Region: Response_reg; pfam00072 1121451005227 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121451005228 active site 1121451005229 phosphorylation site [posttranslational modification] 1121451005230 intermolecular recognition site; other site 1121451005231 dimerization interface [polypeptide binding]; other site 1121451005232 nitrogen fixation negative regulator NifL; Region: nifL_nitrog; TIGR02938 1121451005233 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1121451005234 putative active site [active] 1121451005235 heme pocket [chemical binding]; other site 1121451005236 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1121451005237 dimer interface [polypeptide binding]; other site 1121451005238 phosphorylation site [posttranslational modification] 1121451005239 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1121451005240 ATP binding site [chemical binding]; other site 1121451005241 Mg2+ binding site [ion binding]; other site 1121451005242 G-X-G motif; other site 1121451005243 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 1121451005244 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121451005245 active site 1121451005246 phosphorylation site [posttranslational modification] 1121451005247 intermolecular recognition site; other site 1121451005248 dimerization interface [polypeptide binding]; other site 1121451005249 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1121451005250 Walker A motif; other site 1121451005251 ATP binding site [chemical binding]; other site 1121451005252 Walker B motif; other site 1121451005253 arginine finger; other site 1121451005254 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1121451005255 Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823 1121451005256 TSCPD domain; Region: TSCPD; cl14834 1121451005257 putative metalloenzyme radical SAM/SPASM domain maturase; Region: rSAM_Geo_metal; TIGR04311 1121451005258 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1121451005259 FeS/SAM binding site; other site 1121451005260 Domain of unknown function (DUF4008); Region: DUF4008; pfam13186 1121451005261 C-terminal peptidase (prc); Region: prc; TIGR00225 1121451005262 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1121451005263 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 1121451005264 Active site serine [active] 1121451005265 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1121451005266 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1121451005267 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 1121451005268 metal ion-dependent adhesion site (MIDAS); other site 1121451005269 Tubulin like; Region: Tubulin_2; pfam13809 1121451005270 AmmeMemoRadiSam system radical SAM enzyme; Region: AmmeMemoSam_rS; TIGR04337 1121451005271 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1121451005272 FeS/SAM binding site; other site 1121451005273 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 1121451005274 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 1121451005275 dimerization interface [polypeptide binding]; other site 1121451005276 putative ATP binding site [chemical binding]; other site 1121451005277 Protein of unknown function (DUF1318); Region: DUF1318; cl01547 1121451005278 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1121451005279 Radical SAM superfamily; Region: Radical_SAM; pfam04055 1121451005280 FeS/SAM binding site; other site 1121451005281 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1121451005282 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1121451005283 dimer interface [polypeptide binding]; other site 1121451005284 phosphorylation site [posttranslational modification] 1121451005285 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1121451005286 ATP binding site [chemical binding]; other site 1121451005287 Mg2+ binding site [ion binding]; other site 1121451005288 G-X-G motif; other site 1121451005289 EAL domain; Region: EAL; pfam00563 1121451005290 Predicted signal transduction protein containing EAL and modified HD-GYP domains [Signal transduction mechanisms]; Region: COG3434 1121451005291 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 1121451005292 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 1121451005293 23S rRNA interface [nucleotide binding]; other site 1121451005294 L3 interface [polypeptide binding]; other site 1121451005295 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 1121451005296 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 1121451005297 motif 1; other site 1121451005298 active site 1121451005299 motif 2; other site 1121451005300 motif 3; other site 1121451005301 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 1121451005302 recombinase A; Provisional; Region: recA; PRK09354 1121451005303 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 1121451005304 hexamer interface [polypeptide binding]; other site 1121451005305 Walker A motif; other site 1121451005306 ATP binding site [chemical binding]; other site 1121451005307 Walker B motif; other site 1121451005308 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 1121451005309 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 1121451005310 Ligand Binding Site [chemical binding]; other site 1121451005311 Domain of unknown function (DUF814); Region: DUF814; pfam05670 1121451005312 Ca2+/Na+ antiporter [Inorganic ion transport and metabolism]; Region: ECM27; COG0530 1121451005313 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 1121451005314 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 1121451005315 dipeptide/tripeptide permease B; Provisional; Region: PRK10207 1121451005316 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1121451005317 putative substrate translocation pore; other site 1121451005318 POT family; Region: PTR2; cl17359 1121451005319 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 1121451005320 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 1121451005321 Tetraacyldisaccharide-1-P 4'-kinase [Cell envelope biogenesis, outer membrane]; Region: LpxK; COG1663 1121451005322 Tetraacyldisaccharide-1-P 4'-kinase; Region: LpxK; pfam02606 1121451005323 ribonuclease R; Region: RNase_R; TIGR02063 1121451005324 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 1121451005325 RNB domain; Region: RNB; pfam00773 1121451005326 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 1121451005327 RNA binding site [nucleotide binding]; other site 1121451005328 Bacteriophage CI repressor helix-turn-helix domain; Region: Phage_CI_repr; pfam07022 1121451005329 Predicted transcriptional regulator [Transcription]; Region: COG2932 1121451005330 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1121451005331 Catalytic site [active] 1121451005332 UPF0489 domain; Region: UPF0489; pfam12640 1121451005333 ABC-type amino acid transport/signal transduction systems, periplasmic component/domain [Amino acid transport and metabolism / Signal transduction mechanisms]; Region: HisJ; COG0834 1121451005334 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1121451005335 substrate binding pocket [chemical binding]; other site 1121451005336 membrane-bound complex binding site; other site 1121451005337 hinge residues; other site 1121451005338 prolyl-tRNA synthetase, family II; Region: proS_fam_II; TIGR00409 1121451005339 Galactose binding lectin domain; Region: Gal_Lectin; pfam02140 1121451005340 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 1121451005341 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1121451005342 substrate binding pocket [chemical binding]; other site 1121451005343 membrane-bound complex binding site; other site 1121451005344 hinge residues; other site 1121451005345 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 1121451005346 putative catalytic site [active] 1121451005347 putative phosphate binding site [ion binding]; other site 1121451005348 putative metal binding site [ion binding]; other site 1121451005349 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1121451005350 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 1121451005351 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1121451005352 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1121451005353 putative active site [active] 1121451005354 heme pocket [chemical binding]; other site 1121451005355 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1121451005356 dimer interface [polypeptide binding]; other site 1121451005357 phosphorylation site [posttranslational modification] 1121451005358 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1121451005359 ATP binding site [chemical binding]; other site 1121451005360 Mg2+ binding site [ion binding]; other site 1121451005361 G-X-G motif; other site 1121451005362 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1121451005363 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1121451005364 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121451005365 active site 1121451005366 phosphorylation site [posttranslational modification] 1121451005367 intermolecular recognition site; other site 1121451005368 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 1121451005369 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 1121451005370 trimerization site [polypeptide binding]; other site 1121451005371 active site 1121451005372 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 1121451005373 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1121451005374 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 1121451005375 dimerization interface [polypeptide binding]; other site 1121451005376 substrate binding pocket [chemical binding]; other site 1121451005377 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; cl17497 1121451005378 Protein of unknown function, DUF482; Region: DUF482; pfam04339 1121451005379 Uncharacterized protein family (UPF0227); Region: UPF0227; cl14886 1121451005380 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1121451005381 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 1121451005382 Uncharacterized protein family UPF0052; Region: UPF0052; pfam01933 1121451005383 phosphate binding site [ion binding]; other site 1121451005384 putative substrate binding pocket [chemical binding]; other site 1121451005385 dimer interface [polypeptide binding]; other site 1121451005386 endonuclease IV; Provisional; Region: PRK01060 1121451005387 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 1121451005388 AP (apurinic/apyrimidinic) site pocket; other site 1121451005389 DNA interaction; other site 1121451005390 Metal-binding active site; metal-binding site 1121451005391 Uncharacterized protein conserved in bacteria (DUF2325); Region: DUF2325; pfam10087 1121451005392 PAS domain S-box; Region: sensory_box; TIGR00229 1121451005393 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1121451005394 putative active site [active] 1121451005395 heme pocket [chemical binding]; other site 1121451005396 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1121451005397 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1121451005398 dimer interface [polypeptide binding]; other site 1121451005399 phosphorylation site [posttranslational modification] 1121451005400 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1121451005401 ATP binding site [chemical binding]; other site 1121451005402 Mg2+ binding site [ion binding]; other site 1121451005403 G-X-G motif; other site 1121451005404 Response regulator receiver domain; Region: Response_reg; pfam00072 1121451005405 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121451005406 active site 1121451005407 phosphorylation site [posttranslational modification] 1121451005408 intermolecular recognition site; other site 1121451005409 dimerization interface [polypeptide binding]; other site 1121451005410 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 1121451005411 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 1121451005412 phosphate binding site [ion binding]; other site 1121451005413 putative substrate binding pocket [chemical binding]; other site 1121451005414 dimer interface [polypeptide binding]; other site 1121451005415 HprK-related kinase B; Region: HprK_rel_B; TIGR04355 1121451005416 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 1121451005417 active site 1121451005418 ATP-grasp enzyme, GAK system; Region: grasp_GAK; TIGR04356 1121451005419 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1121451005420 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 1121451005421 PhoU domain; Region: PhoU; pfam01895 1121451005422 PhoU domain; Region: PhoU; pfam01895 1121451005423 Phosphotransferase enzyme family; Region: APH; pfam01636 1121451005424 amphi-Trp domain; Region: amphi-Trp; TIGR04354 1121451005425 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 1121451005426 XXXCH domain; Region: XXXCH_domain; TIGR04358 1121451005427 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1121451005428 Zn2+ binding site [ion binding]; other site 1121451005429 Mg2+ binding site [ion binding]; other site 1121451005430 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1121451005431 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1121451005432 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 1121451005433 dimerization interface [polypeptide binding]; other site 1121451005434 substrate binding pocket [chemical binding]; other site 1121451005435 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 1121451005436 Protein of unknown function (DUF721); Region: DUF721; pfam05258 1121451005437 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1121451005438 putative DNA binding site [nucleotide binding]; other site 1121451005439 dimerization interface [polypeptide binding]; other site 1121451005440 putative Zn2+ binding site [ion binding]; other site 1121451005441 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1121451005442 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1121451005443 S-adenosylmethionine binding site [chemical binding]; other site 1121451005444 Adenosylhomocysteinase; Provisional; Region: PTZ00075 1121451005445 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 1121451005446 homotetramer interface [polypeptide binding]; other site 1121451005447 ligand binding site [chemical binding]; other site 1121451005448 catalytic site [active] 1121451005449 NAD binding site [chemical binding]; other site 1121451005450 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1121451005451 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1121451005452 ATP binding site [chemical binding]; other site 1121451005453 Mg++ binding site [ion binding]; other site 1121451005454 motif III; other site 1121451005455 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1121451005456 nucleotide binding region [chemical binding]; other site 1121451005457 ATP-binding site [chemical binding]; other site 1121451005458 RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399 1121451005459 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042 1121451005460 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 1121451005461 aromatic amino acid transport protein; Region: araaP; TIGR00837 1121451005462 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 1121451005463 Aspartase; Region: Aspartase; cd01357 1121451005464 active sites [active] 1121451005465 tetramer interface [polypeptide binding]; other site 1121451005466 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1121451005467 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1121451005468 putative active site [active] 1121451005469 heme pocket [chemical binding]; other site 1121451005470 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1121451005471 putative active site [active] 1121451005472 heme pocket [chemical binding]; other site 1121451005473 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1121451005474 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1121451005475 metal binding site [ion binding]; metal-binding site 1121451005476 active site 1121451005477 I-site; other site 1121451005478 Predicted permeases [General function prediction only]; Region: RarD; COG2962 1121451005479 Multidrug resistance efflux transporter; Region: EmrE; pfam13536 1121451005480 DhnA-type fructose-1,6-bisphosphate aldolase and related enzymes [Carbohydrate transport and metabolism]; Region: FbaB; COG1830 1121451005481 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 1121451005482 putative active site; other site 1121451005483 catalytic residue [active] 1121451005484 Predicted alternative 3-dehydroquinate synthase [Amino acid transport and metabolism]; Region: COG1465 1121451005485 3-dehydroquinate synthase; Provisional; Region: PRK02290 1121451005486 Chorismate mutase type II; Region: CM_2; smart00830 1121451005487 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 1121451005488 Prephenate dehydratase; Region: PDT; pfam00800 1121451005489 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 1121451005490 putative L-Phe binding site [chemical binding]; other site 1121451005491 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 1121451005492 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 1121451005493 hinge; other site 1121451005494 active site 1121451005495 arogenate dehydrogenase; Region: PLN02256 1121451005496 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 1121451005497 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 1121451005498 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1121451005499 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 1121451005500 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 1121451005501 glutamine binding [chemical binding]; other site 1121451005502 catalytic triad [active] 1121451005503 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1121451005504 anthranilate phosphoribosyltransferase; Region: trpD; TIGR01245 1121451005505 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 1121451005506 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 1121451005507 active site 1121451005508 ribulose/triose binding site [chemical binding]; other site 1121451005509 phosphate binding site [ion binding]; other site 1121451005510 substrate (anthranilate) binding pocket [chemical binding]; other site 1121451005511 product (indole) binding pocket [chemical binding]; other site 1121451005512 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 1121451005513 active site 1121451005514 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 1121451005515 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 1121451005516 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1121451005517 catalytic residue [active] 1121451005518 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 1121451005519 substrate binding site [chemical binding]; other site 1121451005520 active site 1121451005521 catalytic residues [active] 1121451005522 heterodimer interface [polypeptide binding]; other site 1121451005523 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1121451005524 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1121451005525 dimerization interface [polypeptide binding]; other site 1121451005526 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1121451005527 dimer interface [polypeptide binding]; other site 1121451005528 phosphorylation site [posttranslational modification] 1121451005529 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1121451005530 ATP binding site [chemical binding]; other site 1121451005531 Mg2+ binding site [ion binding]; other site 1121451005532 G-X-G motif; other site 1121451005533 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1121451005534 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121451005535 active site 1121451005536 phosphorylation site [posttranslational modification] 1121451005537 intermolecular recognition site; other site 1121451005538 dimerization interface [polypeptide binding]; other site 1121451005539 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1121451005540 DNA binding site [nucleotide binding] 1121451005541 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 1121451005542 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1121451005543 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1121451005544 HlyD family secretion protein; Region: HlyD_3; pfam13437 1121451005545 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 1121451005546 Protein export membrane protein; Region: SecD_SecF; cl14618 1121451005547 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 1121451005548 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 1121451005549 putative active site [active] 1121451005550 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 1121451005551 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 1121451005552 Flagellar hook capping protein [Cell motility and secretion]; Region: FlgD; COG1843 1121451005553 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 1121451005554 flagellar hook protein FlgE; Validated; Region: flgE; PRK05841 1121451005555 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 1121451005556 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1121451005557 flagellin; Provisional; Region: PRK12802 1121451005558 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 1121451005559 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 1121451005560 ribonuclease III; Reviewed; Region: rnc; PRK00102 1121451005561 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 1121451005562 dimerization interface [polypeptide binding]; other site 1121451005563 active site 1121451005564 metal binding site [ion binding]; metal-binding site 1121451005565 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 1121451005566 dsRNA binding site [nucleotide binding]; other site 1121451005567 acetyl coenzyme A synthetase (ADP forming), alpha domain; Region: AcCoA-syn-alpha; TIGR02717 1121451005568 CoA binding domain; Region: CoA_binding_2; pfam13380 1121451005569 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 1121451005570 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 1121451005571 BioD-like N-terminal domain of phosphotransacetylase [General function prediction only]; Region: Pta; COG0857 1121451005572 DRTGG domain; Region: DRTGG; pfam07085 1121451005573 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 1121451005574 ABC-type amino acid transport/signal transduction systems, periplasmic component/domain [Amino acid transport and metabolism / Signal transduction mechanisms]; Region: HisJ; COG0834 1121451005575 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1121451005576 substrate binding pocket [chemical binding]; other site 1121451005577 membrane-bound complex binding site; other site 1121451005578 hinge residues; other site 1121451005579 dihydrolipoamide dehydrogenase; Region: lipoamide_DH; TIGR01350 1121451005580 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 1121451005581 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1121451005582 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1121451005583 glycine dehydrogenase subunit 2; Validated; Region: PRK04366 1121451005584 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1121451005585 catalytic residue [active] 1121451005586 Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403 1121451005587 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 1121451005588 tetramer interface [polypeptide binding]; other site 1121451005589 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1121451005590 catalytic residue [active] 1121451005591 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 1121451005592 lipoyl attachment site [posttranslational modification]; other site 1121451005593 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1121451005594 S-adenosylmethionine binding site [chemical binding]; other site 1121451005595 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1121451005596 nickel responsive regulator; Provisional; Region: PRK04460 1121451005597 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 1121451005598 NikR C terminal nickel binding domain; Region: NikR_C; pfam08753 1121451005599 putative GTP cyclohydrolase; Provisional; Region: PRK13674 1121451005600 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1121451005601 active site residue [active] 1121451005602 Protein of unknown function (DUF1499); Region: DUF1499; cl01841 1121451005603 Transcriptional regulator; Region: Rrf2; cl17282 1121451005604 Rrf2 family protein; Region: rrf2_super; TIGR00738 1121451005605 Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl17341 1121451005606 Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509 1121451005607 D-xylose transporter XylE; Provisional; Region: xylE; PRK10077 1121451005608 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1121451005609 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 1121451005610 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1121451005611 Walker A motif; other site 1121451005612 ATP binding site [chemical binding]; other site 1121451005613 Walker B motif; other site 1121451005614 arginine finger; other site 1121451005615 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1121451005616 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 1121451005617 Memo (mediator of ErbB2-driven cell motility) is co-precipitated with the C terminus of ErbB2, a protein involved in cell motility; Region: MEMO_like; cd07361 1121451005618 putative ligand binding pocket/active site [active] 1121451005619 putative metal binding site [ion binding]; other site 1121451005620 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 1121451005621 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 1121451005622 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 1121451005623 AAA domain; Region: AAA_26; pfam13500 1121451005624 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 1121451005625 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1121451005626 adenosylmethionine-8-amino-7-oxononanoate transaminase; Region: bioA; TIGR00508 1121451005627 inhibitor-cofactor binding pocket; inhibition site 1121451005628 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1121451005629 catalytic residue [active] 1121451005630 biotin synthase; Region: bioB; TIGR00433 1121451005631 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 1121451005632 Flagellar protein YcgR; Region: YcgR_2; pfam12945 1121451005633 PilZ domain; Region: PilZ; pfam07238 1121451005634 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1121451005635 binding surface 1121451005636 TPR motif; other site 1121451005637 TPR repeat; Region: TPR_11; pfam13414 1121451005638 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 1121451005639 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1121451005640 Walker A/P-loop; other site 1121451005641 ATP binding site [chemical binding]; other site 1121451005642 Q-loop/lid; other site 1121451005643 ABC transporter signature motif; other site 1121451005644 Walker B; other site 1121451005645 D-loop; other site 1121451005646 H-loop/switch region; other site 1121451005647 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 1121451005648 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 1121451005649 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1121451005650 Walker A/P-loop; other site 1121451005651 ATP binding site [chemical binding]; other site 1121451005652 Q-loop/lid; other site 1121451005653 ABC transporter signature motif; other site 1121451005654 Walker B; other site 1121451005655 D-loop; other site 1121451005656 H-loop/switch region; other site 1121451005657 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 1121451005658 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 1121451005659 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1121451005660 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1121451005661 dimer interface [polypeptide binding]; other site 1121451005662 conserved gate region; other site 1121451005663 putative PBP binding loops; other site 1121451005664 ABC-ATPase subunit interface; other site 1121451005665 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1121451005666 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1121451005667 dimer interface [polypeptide binding]; other site 1121451005668 conserved gate region; other site 1121451005669 putative PBP binding loops; other site 1121451005670 ABC-ATPase subunit interface; other site 1121451005671 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_2; cd08498 1121451005672 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 1121451005673 radical SAM family uncharacterized protein; Region: rSAM_fuse_unch; TIGR03960 1121451005674 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1121451005675 FeS/SAM binding site; other site 1121451005676 radical SAM-linked protein; Region: sam_1_link_chp; TIGR03936 1121451005677 Uncharacterized protein conserved in bacteria (DUF2344); Region: DUF2344; pfam10105 1121451005678 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 1121451005679 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1121451005680 acetyl-CoA synthetase; Provisional; Region: PRK00174 1121451005681 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 1121451005682 active site 1121451005683 CoA binding site [chemical binding]; other site 1121451005684 acyl-activating enzyme (AAE) consensus motif; other site 1121451005685 AMP binding site [chemical binding]; other site 1121451005686 acetate binding site [chemical binding]; other site 1121451005687 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 1121451005688 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 1121451005689 putative active site [active] 1121451005690 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 1121451005691 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1121451005692 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1121451005693 homodimer interface [polypeptide binding]; other site 1121451005694 catalytic residue [active] 1121451005695 hypothetical protein; Provisional; Region: PRK11568 1121451005696 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 1121451005697 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 1121451005698 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 1121451005699 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1121451005700 PilZ domain; Region: PilZ; pfam07238 1121451005701 Predicted exonuclease [DNA replication, recombination, and repair]; Region: COG3359 1121451005702 RNase_H superfamily; Region: RNase_H_2; pfam13482 1121451005703 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 1121451005704 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1121451005705 ATP binding site [chemical binding]; other site 1121451005706 Mg++ binding site [ion binding]; other site 1121451005707 motif III; other site 1121451005708 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1121451005709 nucleotide binding region [chemical binding]; other site 1121451005710 ATP-binding site [chemical binding]; other site 1121451005711 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 1121451005712 MiaB-like tRNA modifying enzyme; Region: MiaB-like-C; TIGR01579 1121451005713 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1121451005714 FeS/SAM binding site; other site 1121451005715 hypothetical protein; Provisional; Region: PRK11820 1121451005716 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 1121451005717 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 1121451005718 hypothetical protein; Provisional; Region: PRK04323 1121451005719 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 1121451005720 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 1121451005721 catalytic site [active] 1121451005722 G-X2-G-X-G-K; other site 1121451005723 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 1121451005724 active site 1121451005725 dimer interface [polypeptide binding]; other site 1121451005726 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1121451005727 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1121451005728 binding surface 1121451005729 TPR motif; other site 1121451005730 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1121451005731 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 1121451005732 DHH family; Region: DHH; pfam01368 1121451005733 DHHA1 domain; Region: DHHA1; pfam02272 1121451005734 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 1121451005735 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1121451005736 dimerization interface [polypeptide binding]; other site 1121451005737 PAS fold; Region: PAS_4; pfam08448 1121451005738 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1121451005739 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1121451005740 dimer interface [polypeptide binding]; other site 1121451005741 putative CheW interface [polypeptide binding]; other site 1121451005742 Protein of unknown function (DUF4242); Region: DUF4242; pfam14026 1121451005743 lipoyl synthase; Provisional; Region: PRK05481 1121451005744 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1121451005745 FeS/SAM binding site; other site 1121451005746 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 1121451005747 Mitochondrial small ribosomal subunit Rsm22; Region: Rsm22; cl17847 1121451005748 Uncharacterized metal-binding protein [General function prediction only]; Region: COG3894 1121451005749 Cobalt chelatase (CbiK); Region: CbiK; pfam06180 1121451005750 Class II Chelatase: a family of ATP-independent monomeric or homodimeric enzymes that catalyze the insertion of metal into protoporphyrin rings. This family includes protoporphyrin IX ferrochelatase (HemH), sirohydrochlorin ferrochelatase (SirB) and the...; Region: Chelatase_Class_II; cl02784 1121451005751 active site 1121451005752 Class II Chelatase: a family of ATP-independent monomeric or homodimeric enzymes that catalyze the insertion of metal into protoporphyrin rings. This family includes protoporphyrin IX ferrochelatase (HemH), sirohydrochlorin ferrochelatase (SirB) and the...; Region: Chelatase_Class_II; cl02784 1121451005753 active site 1121451005754 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 1121451005755 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1121451005756 ATP binding site [chemical binding]; other site 1121451005757 Mg2+ binding site [ion binding]; other site 1121451005758 G-X-G motif; other site 1121451005759 CheW-like domain; Region: CheW; pfam01584 1121451005760 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1121451005761 putative binding surface; other site 1121451005762 active site 1121451005763 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121451005764 Response regulator receiver domain; Region: Response_reg; pfam00072 1121451005765 active site 1121451005766 phosphorylation site [posttranslational modification] 1121451005767 intermolecular recognition site; other site 1121451005768 dimerization interface [polypeptide binding]; other site 1121451005769 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1121451005770 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1121451005771 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 1121451005772 active site 1121451005773 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 1121451005774 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 1121451005775 nudix motif; other site 1121451005776 glycogen synthase; Provisional; Region: glgA; PRK00654 1121451005777 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 1121451005778 ADP-binding pocket [chemical binding]; other site 1121451005779 homodimer interface [polypeptide binding]; other site 1121451005780 glycogen branching enzyme; Provisional; Region: PRK12313 1121451005781 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 1121451005782 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 1121451005783 active site 1121451005784 catalytic site [active] 1121451005785 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 1121451005786 4-hydroxythreonine-4-phosphate dehydrogenase; Region: pdxA; TIGR00557 1121451005787 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 1121451005788 D,D-heptose 1,7-bisphosphate phosphatase; Validated; Region: PRK08942 1121451005789 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1121451005790 active site 1121451005791 motif I; other site 1121451005792 motif II; other site 1121451005793 TPR repeat; Region: TPR_11; pfam13414 1121451005794 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1121451005795 TPR motif; other site 1121451005796 binding surface 1121451005797 TPR repeat; Region: TPR_11; pfam13414 1121451005798 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 1121451005799 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988 1121451005800 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 1121451005801 catalytic site [active] 1121451005802 subunit interface [polypeptide binding]; other site 1121451005803 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 1121451005804 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 1121451005805 Ligand binding site; other site 1121451005806 oligomer interface; other site 1121451005807 3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749 1121451005808 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 1121451005809 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 1121451005810 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 1121451005811 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1121451005812 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 1121451005813 Dissimilatory sulfite reductase (desulfoviridin), gamma subunit [Inorganic ion transport and metabolism]; Region: DsrC; COG2920 1121451005814 DsrC like protein; Region: DsrC; pfam04358 1121451005815 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 1121451005816 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 1121451005817 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1121451005818 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 1121451005819 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 1121451005820 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 1121451005821 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1121451005822 acyl-activating enzyme (AAE) consensus motif; other site 1121451005823 AMP binding site [chemical binding]; other site 1121451005824 active site 1121451005825 CoA binding site [chemical binding]; other site 1121451005826 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 1121451005827 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 1121451005828 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 1121451005829 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 1121451005830 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1121451005831 dimerization interface [polypeptide binding]; other site 1121451005832 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1121451005833 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1121451005834 dimer interface [polypeptide binding]; other site 1121451005835 putative CheW interface [polypeptide binding]; other site 1121451005836 Cache domain; Region: Cache_1; pfam02743 1121451005837 PAS domain; Region: PAS_9; pfam13426 1121451005838 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1121451005839 putative active site [active] 1121451005840 heme pocket [chemical binding]; other site 1121451005841 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1121451005842 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1121451005843 dimer interface [polypeptide binding]; other site 1121451005844 putative CheW interface [polypeptide binding]; other site 1121451005845 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 1121451005846 Response regulator receiver domain; Region: Response_reg; pfam00072 1121451005847 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121451005848 active site 1121451005849 phosphorylation site [posttranslational modification] 1121451005850 intermolecular recognition site; other site 1121451005851 dimerization interface [polypeptide binding]; other site 1121451005852 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 1121451005853 dimer interface [polypeptide binding]; other site 1121451005854 active site 1121451005855 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 1121451005856 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 1121451005857 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1121451005858 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1121451005859 putative active site [active] 1121451005860 heme pocket [chemical binding]; other site 1121451005861 PAS domain; Region: PAS; smart00091 1121451005862 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 1121451005863 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1121451005864 dimer interface [polypeptide binding]; other site 1121451005865 phosphorylation site [posttranslational modification] 1121451005866 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1121451005867 ATP binding site [chemical binding]; other site 1121451005868 Mg2+ binding site [ion binding]; other site 1121451005869 G-X-G motif; other site 1121451005870 flagellin; Provisional; Region: PRK12804 1121451005871 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 1121451005872 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 1121451005873 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 1121451005874 isocitrate dehydrogenase; Validated; Region: PRK07362 1121451005875 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1121451005876 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1121451005877 HlyD family secretion protein; Region: HlyD_3; pfam13437 1121451005878 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 1121451005879 aspartate aminotransferase; Provisional; Region: PRK05764 1121451005880 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1121451005881 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1121451005882 homodimer interface [polypeptide binding]; other site 1121451005883 catalytic residue [active] 1121451005884 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 1121451005885 Glutamine amidotransferase class-I; Region: GATase; pfam00117 1121451005886 glutamine binding [chemical binding]; other site 1121451005887 catalytic triad [active] 1121451005888 aminodeoxychorismate synthase, component I, clade 2; Region: PabB-clade2; TIGR01824 1121451005889 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1121451005890 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 1121451005891 homodimer interface [polypeptide binding]; other site 1121451005892 substrate-cofactor binding pocket; other site 1121451005893 Aminotransferase class IV; Region: Aminotran_4; pfam01063 1121451005894 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1121451005895 catalytic residue [active] 1121451005896 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 1121451005897 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 1121451005898 active site 1121451005899 HIGH motif; other site 1121451005900 dimer interface [polypeptide binding]; other site 1121451005901 KMSKS motif; other site 1121451005902 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 1121451005903 Peptidase family M50; Region: Peptidase_M50; pfam02163 1121451005904 active site 1121451005905 putative substrate binding region [chemical binding]; other site 1121451005906 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121451005907 active site 1121451005908 phosphorylation site [posttranslational modification] 1121451005909 intermolecular recognition site; other site 1121451005910 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 1121451005911 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 1121451005912 Ligand Binding Site [chemical binding]; other site 1121451005913 TIGR00269 family protein; Region: TIGR00269 1121451005914 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1121451005915 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 1121451005916 active site 1121451005917 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 1121451005918 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 1121451005919 RNase E interface [polypeptide binding]; other site 1121451005920 trimer interface [polypeptide binding]; other site 1121451005921 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 1121451005922 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 1121451005923 RNase E interface [polypeptide binding]; other site 1121451005924 trimer interface [polypeptide binding]; other site 1121451005925 active site 1121451005926 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 1121451005927 putative nucleic acid binding region [nucleotide binding]; other site 1121451005928 G-X-X-G motif; other site 1121451005929 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 1121451005930 RNA binding site [nucleotide binding]; other site 1121451005931 domain interface; other site 1121451005932 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 1121451005933 16S/18S rRNA binding site [nucleotide binding]; other site 1121451005934 S13e-L30e interaction site [polypeptide binding]; other site 1121451005935 25S rRNA binding site [nucleotide binding]; other site 1121451005936 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 1121451005937 tRNA pseudouridine(55) synthase; Region: TruB; TIGR00431 1121451005938 RNA binding site [nucleotide binding]; other site 1121451005939 active site 1121451005940 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 1121451005941 DHH family; Region: DHH; pfam01368 1121451005942 DHHA1 domain; Region: DHHA1; pfam02272 1121451005943 Ribosome-binding factor A; Region: RBFA; pfam02033 1121451005944 Protein of unknown function (DUF503); Region: DUF503; pfam04456 1121451005945 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1121451005946 translation initiation factor IF-2; Region: IF-2; TIGR00487 1121451005947 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1121451005948 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 1121451005949 G1 box; other site 1121451005950 putative GEF interaction site [polypeptide binding]; other site 1121451005951 GTP/Mg2+ binding site [chemical binding]; other site 1121451005952 Switch I region; other site 1121451005953 G2 box; other site 1121451005954 G3 box; other site 1121451005955 Switch II region; other site 1121451005956 G4 box; other site 1121451005957 G5 box; other site 1121451005958 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 1121451005959 Translation-initiation factor 2; Region: IF-2; pfam11987 1121451005960 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 1121451005961 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cl00189 1121451005962 putative RNA binding cleft [nucleotide binding]; other site 1121451005963 transcription elongation factor NusA; Validated; Region: nusA; PRK09202 1121451005964 NusA N-terminal domain; Region: NusA_N; pfam08529 1121451005965 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 1121451005966 RNA binding site [nucleotide binding]; other site 1121451005967 homodimer interface [polypeptide binding]; other site 1121451005968 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 1121451005969 G-X-X-G motif; other site 1121451005970 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 1121451005971 G-X-X-G motif; other site 1121451005972 ribosome maturation protein RimP; Reviewed; Region: PRK00092 1121451005973 Sm and related proteins; Region: Sm_like; cl00259 1121451005974 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 1121451005975 putative oligomer interface [polypeptide binding]; other site 1121451005976 putative RNA binding site [nucleotide binding]; other site 1121451005977 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgG; COG4786 1121451005978 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 1121451005979 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 1121451005980 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693 1121451005981 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 1121451005982 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1121451005983 SAF-like; Region: SAF_2; pfam13144 1121451005984 flagella basal body P-ring formation protein FlgA; Region: flgA_cterm; TIGR03170 1121451005985 flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK12696 1121451005986 Flagellar L-ring protein; Region: FlgH; pfam02107 1121451005987 flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303 1121451005988 flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622 1121451005989 Rod binding protein; Region: Rod-binding; cl01626 1121451005990 FlgN protein; Region: FlgN; pfam05130 1121451005991 flagellar hook-associated protein FlgK; Region: flgK_ends; TIGR02492 1121451005992 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK08471 1121451005993 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1121451005994 flagellar hook-associated protein FlgL; Provisional; Region: flgL; PRK12718 1121451005995 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 1121451005996 Global regulator protein family; Region: CsrA; pfam02599 1121451005997 flagellar assembly protein FliW; Provisional; Region: PRK13285 1121451005998 flagellar biosynthesis anti-sigma factor FlgM; Region: FlgM_jcvi; TIGR03824 1121451005999 NAD kinase [Coenzyme metabolism]; Region: nadF; COG0061 1121451006000 ATP-NAD kinase; Region: NAD_kinase; pfam01513 1121451006001 Protein of unknown function DUF89; Region: DUF89; cl15397 1121451006002 MltA specific insert domain; Region: MltA; smart00925 1121451006003 3D domain; Region: 3D; pfam06725 1121451006004 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 1121451006005 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 1121451006006 GatB domain; Region: GatB_Yqey; smart00845 1121451006007 Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]; Region: COG0182; cl00348 1121451006008 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 1121451006009 GTP-binding protein Der; Reviewed; Region: PRK00093 1121451006010 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 1121451006011 G1 box; other site 1121451006012 GTP/Mg2+ binding site [chemical binding]; other site 1121451006013 Switch I region; other site 1121451006014 G2 box; other site 1121451006015 Switch II region; other site 1121451006016 G3 box; other site 1121451006017 G4 box; other site 1121451006018 G5 box; other site 1121451006019 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 1121451006020 G1 box; other site 1121451006021 GTP/Mg2+ binding site [chemical binding]; other site 1121451006022 Switch I region; other site 1121451006023 G2 box; other site 1121451006024 G3 box; other site 1121451006025 Switch II region; other site 1121451006026 G4 box; other site 1121451006027 G5 box; other site 1121451006028 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1121451006029 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121451006030 active site 1121451006031 phosphorylation site [posttranslational modification] 1121451006032 intermolecular recognition site; other site 1121451006033 dimerization interface [polypeptide binding]; other site 1121451006034 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1121451006035 DNA binding residues [nucleotide binding] 1121451006036 dimerization interface [polypeptide binding]; other site 1121451006037 integrase; Provisional; Region: PRK09692 1121451006038 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 1121451006039 active site 1121451006040 Int/Topo IB signature motif; other site 1121451006041 Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; cl17523 1121451006042 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1121451006043 non-specific DNA binding site [nucleotide binding]; other site 1121451006044 salt bridge; other site 1121451006045 sequence-specific DNA binding site [nucleotide binding]; other site 1121451006046 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1121451006047 non-specific DNA binding site [nucleotide binding]; other site 1121451006048 salt bridge; other site 1121451006049 sequence-specific DNA binding site [nucleotide binding]; other site 1121451006050 The accessory protein CooC, which contains a nucleotide-binding domain (P-loop) near the N-terminus, participates in the maturation of the nickel center of carbon monoxide dehydrogenase (CODH). CODH from Rhodospirillum rubrum catalyzes the reversible...; Region: CooC; cd02034 1121451006051 P-loop; other site 1121451006052 P-type conjugative transfer ATPase TrbB; Region: TrbB_P; TIGR02782 1121451006053 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 1121451006054 ATP binding site [chemical binding]; other site 1121451006055 Walker A motif; other site 1121451006056 hexamer interface [polypeptide binding]; other site 1121451006057 Walker B motif; other site 1121451006058 TrbC/VIRB2 family; Region: TrbC; pfam04956 1121451006059 conjugal transfer protein TrbD; Provisional; Region: PRK13823 1121451006060 conjugal transfer protein TrbE; Provisional; Region: PRK13891 1121451006061 CagE, TrbE, VirB family, component of type IV transporter system; Region: CagE_TrbE_VirB; pfam03135 1121451006062 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1121451006063 Walker A/P-loop; other site 1121451006064 ATP binding site [chemical binding]; other site 1121451006065 conjugal transfer protein TrbJ; Provisional; Region: PRK13874; cl02193 1121451006066 conjugal transfer protein TrbJ; Provisional; Region: PRK13874; cl02193 1121451006067 TrbL/VirB6 plasmid conjugal transfer protein; Region: TrbL; cl01503 1121451006068 VirB8 protein; Region: VirB8; cl01500 1121451006069 VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cd06911 1121451006070 VirB7 interaction site; other site 1121451006071 conjugal transfer protein TrbH; Provisional; Region: PRK13883 1121451006072 Toxin co-regulated pilus biosynthesis protein Q; Region: TcpQ; pfam10671 1121451006073 type IVB pilus formation outer membrane protein, R64 PilN family; Region: pilus_B_mal_scr; TIGR02520 1121451006074 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 1121451006075 Pilin accessory protein (PilO); Region: PAP_PilO; pfam06864 1121451006076 Type IV pilus biogenesis; Region: Pilus_PilP; pfam11356 1121451006077 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1121451006078 Walker A motif; other site 1121451006079 ATP binding site [chemical binding]; other site 1121451006080 Walker B motif; other site 1121451006081 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1121451006082 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1121451006083 PilS N terminal; Region: PilS; pfam08805 1121451006084 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1121451006085 Walker A motif; other site 1121451006086 ATP binding site [chemical binding]; other site 1121451006087 Walker B motif; other site 1121451006088 PilM; Region: PilM; pfam07419 1121451006089 Bacterial shufflon protein, N-terminal constant region; Region: Shufflon_N; pfam04917 1121451006090 Bacterial conjugation TrbI-like protein; Region: TrbI; cl04242 1121451006091 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1121451006092 Walker A motif; other site 1121451006093 ATP binding site [chemical binding]; other site 1121451006094 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1121451006095 Walker B motif; other site 1121451006096 conjugative transfer signal peptidase TraF; Region: TraF_Ti; TIGR02771 1121451006097 conjugal transfer pilin processing protease TraF; Provisional; Region: PRK13838 1121451006098 DNA topoisomerase III; Provisional; Region: PRK07726 1121451006099 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 1121451006100 active site 1121451006101 putative interdomain interaction site [polypeptide binding]; other site 1121451006102 putative metal-binding site [ion binding]; other site 1121451006103 putative nucleotide binding site [chemical binding]; other site 1121451006104 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 1121451006105 domain I; other site 1121451006106 DNA binding groove [nucleotide binding] 1121451006107 phosphate binding site [ion binding]; other site 1121451006108 domain II; other site 1121451006109 domain III; other site 1121451006110 nucleotide binding site [chemical binding]; other site 1121451006111 catalytic site [active] 1121451006112 domain IV; other site 1121451006113 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1121451006114 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1121451006115 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: HicB; COG4226 1121451006116 HicB family; Region: HicB; pfam05534 1121451006117 Antirestriction protein [DNA replication, recombination, and repair]; Region: COG4227 1121451006118 Domain of unknown function (DUF1738); Region: DUF1738; pfam08401 1121451006119 Protein of unknown function, DUF462; Region: DUF462; cl01190 1121451006120 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4643 1121451006121 TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029 1121451006122 active site 1121451006123 metal binding site [ion binding]; metal-binding site 1121451006124 interdomain interaction site; other site 1121451006125 Cytidylate kinase-like family; Region: Cytidylate_kin2; pfam13189 1121451006126 putative transporter; Provisional; Region: PRK11660 1121451006127 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 1121451006128 Sulfate transporter family; Region: Sulfate_transp; pfam00916 1121451006129 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 1121451006130 Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432 1121451006131 conjugal transfer relaxosome component TraJ; Provisional; Region: PRK13877 1121451006132 Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; pfam09669 1121451006133 helicase superfamily c-terminal domain; Region: HELICc; smart00490 1121451006134 ATP-binding site [chemical binding]; other site 1121451006135 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 1121451006136 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121451006137 active site 1121451006138 phosphorylation site [posttranslational modification] 1121451006139 intermolecular recognition site; other site 1121451006140 CheB methylesterase; Region: CheB_methylest; pfam01339 1121451006141 HEAT repeats; Region: HEAT_2; pfam13646 1121451006142 HEAT repeats; Region: HEAT_2; pfam13646 1121451006143 HEAT repeats; Region: HEAT_2; pfam13646 1121451006144 HEAT repeats; Region: HEAT_2; pfam13646 1121451006145 HEAT repeats; Region: HEAT_2; pfam13646 1121451006146 HEAT repeats; Region: HEAT_2; pfam13646 1121451006147 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 1121451006148 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 1121451006149 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 1121451006150 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1121451006151 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1121451006152 P-loop; other site 1121451006153 Magnesium ion binding site [ion binding]; other site 1121451006154 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1121451006155 Magnesium ion binding site [ion binding]; other site 1121451006156 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 1121451006157 Response regulator receiver domain; Region: Response_reg; pfam00072 1121451006158 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121451006159 active site 1121451006160 phosphorylation site [posttranslational modification] 1121451006161 intermolecular recognition site; other site 1121451006162 dimerization interface [polypeptide binding]; other site 1121451006163 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1121451006164 putative binding surface; other site 1121451006165 active site 1121451006166 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1121451006167 putative binding surface; other site 1121451006168 active site 1121451006169 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1121451006170 putative binding surface; other site 1121451006171 active site 1121451006172 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 1121451006173 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 1121451006174 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1121451006175 ATP binding site [chemical binding]; other site 1121451006176 Mg2+ binding site [ion binding]; other site 1121451006177 G-X-G motif; other site 1121451006178 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 1121451006179 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 1121451006180 Tetratricopeptide repeat; Region: TPR_6; pfam13174 1121451006181 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 1121451006182 DNA protecting protein DprA; Region: dprA; TIGR00732 1121451006183 HDOD domain; Region: HDOD; pfam08668 1121451006184 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 1121451006185 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 1121451006186 active site 1121451006187 phosphorylation site [posttranslational modification] 1121451006188 intermolecular recognition site; other site 1121451006189 dimerization interface [polypeptide binding]; other site 1121451006190 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1121451006191 metal binding site [ion binding]; metal-binding site 1121451006192 active site 1121451006193 I-site; other site 1121451006194 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 1121451006195 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 1121451006196 active site 1121451006197 Int/Topo IB signature motif; other site 1121451006198 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 1121451006199 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 1121451006200 FMN binding site [chemical binding]; other site 1121451006201 substrate binding site [chemical binding]; other site 1121451006202 putative catalytic residue [active] 1121451006203 Predicted dehydrogenase [General function prediction only]; Region: COG0579 1121451006204 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1121451006205 double-strand break repair protein AddB, alphaproteobacterial type; Region: addB_alphas; TIGR02786 1121451006206 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 1121451006207 ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains) [DNA replication, recombination, and repair]; Region: RecB; COG1074 1121451006208 Family description; Region: UvrD_C_2; pfam13538 1121451006209 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 1121451006210 EamA-like transporter family; Region: EamA; pfam00892 1121451006211 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1121451006212 EamA-like transporter family; Region: EamA; pfam00892 1121451006213 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1121451006214 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1121451006215 RNA binding surface [nucleotide binding]; other site 1121451006216 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1121451006217 active site 1121451006218 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 1121451006219 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 1121451006220 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 1121451006221 P loop; other site 1121451006222 GTP binding site [chemical binding]; other site 1121451006223 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 1121451006224 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318 1121451006225 putative dimer interface [polypeptide binding]; other site 1121451006226 putative anticodon binding site; other site 1121451006227 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 1121451006228 homodimer interface [polypeptide binding]; other site 1121451006229 motif 1; other site 1121451006230 motif 2; other site 1121451006231 active site 1121451006232 motif 3; other site 1121451006233 GyrI-like small molecule binding domain; Region: GyrI-like; pfam06445 1121451006234 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1121451006235 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1121451006236 GyrI-like small molecule binding domain; Region: GyrI-like; pfam06445 1121451006237 The SYLF domain (also called DUF500), a novel lipid-binding module; Region: SYLF; cd11524 1121451006238 putative amphipathic alpha helix; other site 1121451006239 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 1121451006240 Putative methyltransferase; Region: Methyltransf_20; pfam12147 1121451006241 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 1121451006242 transmembrane helices; other site 1121451006243 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 1121451006244 TrkA-C domain; Region: TrkA_C; pfam02080 1121451006245 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 1121451006246 DctM-like transporters; Region: DctM; pfam06808 1121451006247 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 1121451006248 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290 1121451006249 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 1121451006250 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 1121451006251 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1121451006252 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1121451006253 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 1121451006254 High-affinity nickel-transport protein; Region: NicO; cl00964 1121451006255 TM1410 hypothetical-related protein; Region: DUF297; cl00997 1121451006256 Curli production assembly/transport component CsgG; Region: CsgG; cl17434 1121451006257 TM1410 hypothetical-related protein; Region: DUF297; pfam03537 1121451006258 C-terminal Putative NodB-like catalytic domain of PelA-like uncharacterized hypothetical proteins found in bacteria; Region: CE4_PelA_like_C; cd10922 1121451006259 putative active site [active] 1121451006260 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1121451006261 TPR motif; other site 1121451006262 binding surface 1121451006263 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1121451006264 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1121451006265 TPR motif; other site 1121451006266 binding surface 1121451006267 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1121451006268 TPR motif; other site 1121451006269 binding surface 1121451006270 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 1121451006271 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1121451006272 GAF domain; Region: GAF_3; pfam13492 1121451006273 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1121451006274 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1121451006275 metal binding site [ion binding]; metal-binding site 1121451006276 active site 1121451006277 I-site; other site 1121451006278 HEAT repeats; Region: HEAT_2; pfam13646 1121451006279 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1121451006280 TPR motif; other site 1121451006281 binding surface 1121451006282 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_3; cd03813 1121451006283 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1121451006284 Predicted membrane protein [Function unknown]; Region: COG4267 1121451006285 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1121451006286 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1121451006287 NAD(P) binding site [chemical binding]; other site 1121451006288 active site 1121451006289 HDOD domain; Region: HDOD; pfam08668 1121451006290 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1121451006291 Zn2+ binding site [ion binding]; other site 1121451006292 Mg2+ binding site [ion binding]; other site 1121451006293 Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675 1121451006294 HAMP domain; Region: HAMP; pfam00672 1121451006295 dimerization interface [polypeptide binding]; other site 1121451006296 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1121451006297 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1121451006298 dimer interface [polypeptide binding]; other site 1121451006299 putative CheW interface [polypeptide binding]; other site 1121451006300 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 1121451006301 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1121451006302 active site residue [active] 1121451006303 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1121451006304 active site residue [active] 1121451006305 Superoxide reductase-like (SORL) domain; present in a family of mononuclear non-heme iron proteins that includes superoxide reductase and desulfoferrodoxin. Superoxide reductase-like proteins scavenge superoxide anion radicals as a defense mechanism...; Region: SORL; cl00014 1121451006306 non-heme iron binding site [ion binding]; other site 1121451006307 Cache domain; Region: Cache_1; pfam02743 1121451006308 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1121451006309 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1121451006310 dimer interface [polypeptide binding]; other site 1121451006311 phosphorylation site [posttranslational modification] 1121451006312 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1121451006313 ATP binding site [chemical binding]; other site 1121451006314 Mg2+ binding site [ion binding]; other site 1121451006315 G-X-G motif; other site 1121451006316 Response regulator receiver domain; Region: Response_reg; pfam00072 1121451006317 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121451006318 active site 1121451006319 phosphorylation site [posttranslational modification] 1121451006320 intermolecular recognition site; other site 1121451006321 dimerization interface [polypeptide binding]; other site 1121451006322 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1121451006323 Ligand Binding Site [chemical binding]; other site 1121451006324 Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075 1121451006325 Protein of unknown function (DUF3365); Region: DUF3365; pfam11845 1121451006326 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 1121451006327 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1121451006328 dimer interface [polypeptide binding]; other site 1121451006329 phosphorylation site [posttranslational modification] 1121451006330 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1121451006331 ATP binding site [chemical binding]; other site 1121451006332 Mg2+ binding site [ion binding]; other site 1121451006333 G-X-G motif; other site 1121451006334 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 1121451006335 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121451006336 active site 1121451006337 phosphorylation site [posttranslational modification] 1121451006338 intermolecular recognition site; other site 1121451006339 dimerization interface [polypeptide binding]; other site 1121451006340 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1121451006341 Walker A motif; other site 1121451006342 ATP binding site [chemical binding]; other site 1121451006343 Walker B motif; other site 1121451006344 arginine finger; other site 1121451006345 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 1121451006346 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1121451006347 Predicted protein-tyrosine phosphatase [Signal transduction mechanisms]; Region: CDC14; COG2453 1121451006348 active site 1121451006349 catalytic residues [active] 1121451006350 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 1121451006351 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1121451006352 active site 1121451006353 CoA binding site [chemical binding]; other site 1121451006354 AMP binding site [chemical binding]; other site 1121451006355 Uncharacterized BCR, YaiI/YqxD family COG1671; Region: DUF188; pfam02639 1121451006356 Formylmethanofuran dehydrogenase subunit E [Energy production and conversion]; Region: COG2191 1121451006357 FmdE, Molybdenum formylmethanofuran dehydrogenase operon; Region: FmdE; pfam02663 1121451006358 MoeA_like. This domain is similar to a domain found in a variety of proteins involved in biosynthesis of molybdopterin cofactor, like MoaB, MogA, and MoeA. There this domain is presumed to bind molybdopterin. The exact function of this subgroup is...; Region: MoeA_like; cd03522 1121451006359 putative MPT binding site; other site 1121451006360 N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; cl17549 1121451006361 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1121451006362 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1121451006363 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1121451006364 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 1121451006365 molybdopterin cofactor binding site; other site 1121451006366 4Fe-4S dicluster domain; Region: Fer4_11; pfam13247 1121451006367 Protein involved in formate dehydrogenase formation; Region: FdhE; pfam04216 1121451006368 formate dehydrogenase accessory protein FdhE; Region: FdhE; TIGR01562 1121451006369 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 1121451006370 active site 1121451006371 thiamine phosphate binding site [chemical binding]; other site 1121451006372 pyrophosphate binding site [ion binding]; other site 1121451006373 thiamine biosynthesis protein ThiF; Provisional; Region: PRK08644 1121451006374 Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cl17196 1121451006375 ATP binding site [chemical binding]; other site 1121451006376 substrate interface [chemical binding]; other site 1121451006377 thiamine biosynthesis protein ThiH; Reviewed; Region: thiH; PRK09240 1121451006378 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1121451006379 FeS/SAM binding site; other site 1121451006380 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 1121451006381 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 1121451006382 ThiS interaction site; other site 1121451006383 putative active site [active] 1121451006384 tetramer interface [polypeptide binding]; other site 1121451006385 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 1121451006386 thiS-thiF/thiG interaction site; other site 1121451006387 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 1121451006388 PhoU domain; Region: PhoU; pfam01895 1121451006389 PhoU domain; Region: PhoU; pfam01895 1121451006390 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 1121451006391 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1121451006392 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1121451006393 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1121451006394 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1121451006395 type I secretion system ATPase, LssB family; Region: type_I_sec_LssB; TIGR03375 1121451006396 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1121451006397 ATP-binding cassette domain of bacteriocin exporters, subfamily C; Region: ABCC_bacteriocin_exporters; cd03245 1121451006398 Walker A/P-loop; other site 1121451006399 ATP binding site [chemical binding]; other site 1121451006400 Q-loop/lid; other site 1121451006401 ABC transporter signature motif; other site 1121451006402 Walker B; other site 1121451006403 D-loop; other site 1121451006404 H-loop/switch region; other site 1121451006405 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 1121451006406 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1121451006407 HlyD family secretion protein; Region: HlyD_3; pfam13437 1121451006408 PAS fold; Region: PAS_4; pfam08448 1121451006409 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1121451006410 Zn2+ binding site [ion binding]; other site 1121451006411 Mg2+ binding site [ion binding]; other site 1121451006412 L-lactate permease; Region: Lactate_perm; cl00701 1121451006413 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 1121451006414 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 1121451006415 type VI secretion-associated protein, VC_A0119 family; Region: VI_chp_7; TIGR03362 1121451006416 Protein of unknown function (DUF770); Region: DUF770; pfam05591 1121451006417 type VI secretion protein, EvpB/VC_A0108 family; Region: VI_chp_2; TIGR03355 1121451006418 Protein of unknown function (DUF877); Region: DUF877; pfam05943 1121451006419 type VI secretion system effector, Hcp1 family; Region: VI_effect_Hcp1; TIGR03344 1121451006420 type VI secretion system lysozyme-like protein; Region: VI_zyme; TIGR03357 1121451006421 Bacterial protein of unknown function (DUF879); Region: DUF879; pfam05947 1121451006422 Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3519 1121451006423 Protein of unknown function (DUF1305); Region: DUF1305; pfam06996 1121451006424 type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345 1121451006425 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1121451006426 Walker A motif; other site 1121451006427 ATP binding site [chemical binding]; other site 1121451006428 Walker B motif; other site 1121451006429 arginine finger; other site 1121451006430 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1121451006431 Walker A motif; other site 1121451006432 ATP binding site [chemical binding]; other site 1121451006433 Walker B motif; other site 1121451006434 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1121451006435 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 1121451006436 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 1121451006437 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 1121451006438 Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507 1121451006439 trimer interface [polypeptide binding]; other site 1121451006440 Uncharacterized protein conserved in bacteria (DUF2169); Region: DUF2169; pfam09937 1121451006441 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1121451006442 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 1121451006443 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1121451006444 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1121451006445 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1121451006446 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1121451006447 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 1121451006448 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1121451006449 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1121451006450 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 1121451006451 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1121451006452 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1121451006453 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1121451006454 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1121451006455 Protein of unknown function (DUF3540); Region: DUF3540; pfam12059 1121451006456 Domain of unknown function (DUF4150); Region: DUF4150; pfam13665 1121451006457 Protein of unknown function (DUF770); Region: DUF770; cl01402 1121451006458 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3517; cl05484 1121451006459 Type VI secretion lipoprotein; Region: T6SS-SciN; pfam12790 1121451006460 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3522; cl01406 1121451006461 Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936 1121451006462 Uncharacterized protein conserved in bacteria (DUF2077); Region: DUF2077; pfam09850 1121451006463 ImcF-related N-terminal domain; Region: ImcF-related_N; pfam14331 1121451006464 Protein of unknown function (DUF1215); Region: DUF1215; pfam06744 1121451006465 AMIN domain; Region: AMIN; pfam11741 1121451006466 Cache domain; Region: Cache_1; pfam02743 1121451006467 HAMP domain; Region: HAMP; pfam00672 1121451006468 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1121451006469 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1121451006470 dimer interface [polypeptide binding]; other site 1121451006471 putative CheW interface [polypeptide binding]; other site 1121451006472 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 1121451006473 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1121451006474 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 1121451006475 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 1121451006476 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 1121451006477 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 1121451006478 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1121451006479 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 1121451006480 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 1121451006481 nucleotide binding site [chemical binding]; other site 1121451006482 NEF interaction site [polypeptide binding]; other site 1121451006483 SBD interface [polypeptide binding]; other site 1121451006484 GrpE; Region: GrpE; pfam01025 1121451006485 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 1121451006486 dimer interface [polypeptide binding]; other site 1121451006487 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 1121451006488 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 1121451006489 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 1121451006490 Fe2+ transport system protein A [Inorganic ion transport and metabolism]; Region: FeoA; COG1918 1121451006491 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 1121451006492 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 1121451006493 G1 box; other site 1121451006494 GTP/Mg2+ binding site [chemical binding]; other site 1121451006495 Switch I region; other site 1121451006496 G2 box; other site 1121451006497 G3 box; other site 1121451006498 Switch II region; other site 1121451006499 G4 box; other site 1121451006500 G5 box; other site 1121451006501 Nucleoside recognition; Region: Gate; pfam07670 1121451006502 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 1121451006503 Nucleoside recognition; Region: Gate; pfam07670 1121451006504 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 1121451006505 Clp amino terminal domain; Region: Clp_N; pfam02861 1121451006506 Clp amino terminal domain; Region: Clp_N; pfam02861 1121451006507 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1121451006508 Walker A motif; other site 1121451006509 ATP binding site [chemical binding]; other site 1121451006510 Walker B motif; other site 1121451006511 arginine finger; other site 1121451006512 Calmodulin-binding; Region: Enkurin; pfam13864 1121451006513 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1121451006514 Walker A motif; other site 1121451006515 ATP binding site [chemical binding]; other site 1121451006516 Walker B motif; other site 1121451006517 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1121451006518 MerR HTH family regulatory protein; Region: MerR_2; pfam13591 1121451006519 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 1121451006520 DNA binding residues [nucleotide binding] 1121451006521 curved DNA-binding protein CbpA; Provisional; Region: PRK10266 1121451006522 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1121451006523 HSP70 interaction site [polypeptide binding]; other site 1121451006524 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 1121451006525 substrate binding site [polypeptide binding]; other site 1121451006526 dimer interface [polypeptide binding]; other site 1121451006527 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 1121451006528 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1121451006529 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1121451006530 RNA binding surface [nucleotide binding]; other site 1121451006531 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1121451006532 active site 1121451006533 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 1121451006534 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 1121451006535 CoA-binding site [chemical binding]; other site 1121451006536 ATP-binding [chemical binding]; other site 1121451006537 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1121451006538 active site 1121451006539 Xanthine/uracil permeases [Nucleotide transport and metabolism]; Region: UraA; COG2233 1121451006540 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 1121451006541 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 1121451006542 Ligand Binding Site [chemical binding]; other site 1121451006543 phosphatidylserine decarboxylase; Provisional; Region: PRK05305 1121451006544 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 1121451006545 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 1121451006546 2-isopropylmalate synthase; Validated; Region: PRK00915 1121451006547 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 1121451006548 active site 1121451006549 catalytic residues [active] 1121451006550 metal binding site [ion binding]; metal-binding site 1121451006551 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 1121451006552 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 1121451006553 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 1121451006554 substrate binding site [chemical binding]; other site 1121451006555 ligand binding site [chemical binding]; other site 1121451006556 3-isopropylmalate dehydratase small subunit; Reviewed; Region: leuD; PRK00439 1121451006557 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 1121451006558 substrate binding site [chemical binding]; other site 1121451006559 tartrate dehydrogenase; Region: TTC; TIGR02089 1121451006560 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 1121451006561 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 1121451006562 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 1121451006563 Cobalt chelatase (CbiK); Region: CbiK; pfam06180 1121451006564 Anaerobic cobalamin biosynthetic cobalt chelatase (CbiK), N-terminal domain. CbiK is part of the cobalt-early path for cobalamin biosynthesis. It catalyzes the insertion of cobalt into the oxidized form of precorrin-2, factor II (sirohydrochlorin), the...; Region: CbiK_N; cd03412 1121451006565 active site 1121451006566 C-terminal domain interface [polypeptide binding]; other site 1121451006567 Anaerobic cobalamin biosynthetic cobalt chelatase (CbiK), C-terminal domain. CbiK is part of the cobalt-early path for cobalamin biosynthesis. It catalyzes the insertion of cobalt into the oxidized form of precorrin-2, factor II (sirohydrochlorin), the...; Region: CbiK_C; cd03413 1121451006568 active site 1121451006569 N-terminal domain interface [polypeptide binding]; other site 1121451006570 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1121451006571 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1121451006572 ABC-ATPase subunit interface; other site 1121451006573 dimer interface [polypeptide binding]; other site 1121451006574 putative PBP binding regions; other site 1121451006575 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1121451006576 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1121451006577 Walker A/P-loop; other site 1121451006578 ATP binding site [chemical binding]; other site 1121451006579 Q-loop/lid; other site 1121451006580 ABC transporter signature motif; other site 1121451006581 Walker B; other site 1121451006582 D-loop; other site 1121451006583 H-loop/switch region; other site 1121451006584 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 1121451006585 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1121451006586 intersubunit interface [polypeptide binding]; other site 1121451006587 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 1121451006588 active site 1121451006589 SAM binding site [chemical binding]; other site 1121451006590 homodimer interface [polypeptide binding]; other site 1121451006591 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 1121451006592 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 1121451006593 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1121451006594 catalytic residue [active] 1121451006595 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 1121451006596 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1121451006597 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 1121451006598 FAD binding site [chemical binding]; other site 1121451006599 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 1121451006600 active site 1121451006601 8-oxo-dGMP binding site [chemical binding]; other site 1121451006602 nudix motif; other site 1121451006603 metal binding site [ion binding]; metal-binding site 1121451006604 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1121451006605 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1121451006606 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1121451006607 ABC transporter; Region: ABC_tran_2; pfam12848 1121451006608 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1121451006609 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 1121451006610 GIY-YIG motif/motif A; other site 1121451006611 putative active site [active] 1121451006612 putative metal binding site [ion binding]; other site 1121451006613 Chloramphenicol O-acetyltransferase [Defense mechanisms]; Region: COG4845 1121451006614 Chloramphenicol acetyltransferase; Region: CAT; cl02008 1121451006615 DUF based on E. rectale Gene description (DUF3880); Region: DUF3880; pfam12996 1121451006616 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 1121451006617 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 1121451006618 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1121451006619 active site 1121451006620 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 1121451006621 Uncharacterized protein related to glutamine synthetase [General function prediction only]; Region: COG3968 1121451006622 Glutamine synthetase type III N terminal; Region: GSIII_N; pfam12437 1121451006623 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1121451006624 glutamine ABC transporter periplasmic protein; Reviewed; Region: glnH; PRK09495 1121451006625 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1121451006626 substrate binding pocket [chemical binding]; other site 1121451006627 membrane-bound complex binding site; other site 1121451006628 hinge residues; other site 1121451006629 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1121451006630 dimer interface [polypeptide binding]; other site 1121451006631 conserved gate region; other site 1121451006632 putative PBP binding loops; other site 1121451006633 ABC-ATPase subunit interface; other site 1121451006634 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1121451006635 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1121451006636 Walker A/P-loop; other site 1121451006637 ATP binding site [chemical binding]; other site 1121451006638 Q-loop/lid; other site 1121451006639 ABC transporter signature motif; other site 1121451006640 Walker B; other site 1121451006641 D-loop; other site 1121451006642 H-loop/switch region; other site 1121451006643 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cl17302 1121451006644 Ca2+ binding site [ion binding]; other site 1121451006645 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093 1121451006646 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 1121451006647 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344 1121451006648 putative NAD(P) binding site [chemical binding]; other site 1121451006649 putative active site [active] 1121451006650 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; pfam01977 1121451006651 Pleckstrin homology (PH)-like domains in bacteria (PHb); Region: PH-like_bacteria; cd13225 1121451006652 pentamer interface [polypeptide binding]; other site 1121451006653 dodecaamer interface [polypeptide binding]; other site 1121451006654 conserved hypothetical protein; Region: TIGR02285 1121451006655 Ferredoxin thioredoxin reductase catalytic beta chain; Region: FeThRed_B; cl01977 1121451006656 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1121451006657 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535 1121451006658 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1121451006659 FeS/SAM binding site; other site 1121451006660 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 1121451006661 Formyltransferase, catalytic core domain; Region: FMT_core; cl00395 1121451006662 active site 1121451006663 cosubstrate binding site; other site 1121451006664 substrate binding site [chemical binding]; other site 1121451006665 catalytic site [active] 1121451006666 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 1121451006667 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 1121451006668 putative active site [active] 1121451006669 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 1121451006670 nucleoside/Zn binding site; other site 1121451006671 dimer interface [polypeptide binding]; other site 1121451006672 catalytic motif [active] 1121451006673 CobB/CobQ-like glutamine amidotransferase domain; Region: GATase_5; pfam13507 1121451006674 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 1121451006675 conserved cys residue [active] 1121451006676 CTP synthetase; Validated; Region: pyrG; PRK05380 1121451006677 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 1121451006678 Catalytic site [active] 1121451006679 active site 1121451006680 UTP binding site [chemical binding]; other site 1121451006681 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 1121451006682 active site 1121451006683 putative oxyanion hole; other site 1121451006684 catalytic triad [active] 1121451006685 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198 1121451006686 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 1121451006687 HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662 1121451006688 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1121451006689 active site 1121451006690 motif I; other site 1121451006691 motif II; other site 1121451006692 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 1121451006693 Bacterial SH3 domain; Region: SH3_3; pfam08239 1121451006694 lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002 1121451006695 OstA-like protein; Region: OstA; cl00844 1121451006696 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 1121451006697 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 1121451006698 Walker A/P-loop; other site 1121451006699 ATP binding site [chemical binding]; other site 1121451006700 Q-loop/lid; other site 1121451006701 ABC transporter signature motif; other site 1121451006702 Walker B; other site 1121451006703 D-loop; other site 1121451006704 H-loop/switch region; other site 1121451006705 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 1121451006706 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 1121451006707 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 1121451006708 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 1121451006709 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 1121451006710 30S subunit binding site; other site 1121451006711 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1121451006712 active site 1121451006713 phosphorylation site [posttranslational modification] 1121451006714 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 1121451006715 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 1121451006716 active pocket/dimerization site; other site 1121451006717 active site 1121451006718 phosphorylation site [posttranslational modification] 1121451006719 PTS system sorbose subfamily IIB component; Region: PTSIIB_sorb; pfam03830 1121451006720 active site 1121451006721 phosphorylation site [posttranslational modification] 1121451006722 PTS system sorbose-specific iic component; Region: EII-Sor; cl01506 1121451006723 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427 1121451006724 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 1121451006725 DHHA2 domain; Region: DHHA2; pfam02833 1121451006726 ThiS family; Region: ThiS; pfam02597 1121451006727 charged pocket; other site 1121451006728 hydrophobic patch; other site 1121451006729 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 1121451006730 tetramerization interface [polypeptide binding]; other site 1121451006731 active site 1121451006732 PEGA domain; Region: PEGA; pfam08308 1121451006733 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 1121451006734 Zn2+ binding site [ion binding]; other site 1121451006735 Mg2+ binding site [ion binding]; other site 1121451006736 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 1121451006737 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1121451006738 Walker A/P-loop; other site 1121451006739 ATP binding site [chemical binding]; other site 1121451006740 Q-loop/lid; other site 1121451006741 ABC transporter signature motif; other site 1121451006742 Walker B; other site 1121451006743 D-loop; other site 1121451006744 H-loop/switch region; other site 1121451006745 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 1121451006746 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 1121451006747 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1121451006748 Walker A/P-loop; other site 1121451006749 ATP binding site [chemical binding]; other site 1121451006750 Q-loop/lid; other site 1121451006751 ABC transporter signature motif; other site 1121451006752 Walker B; other site 1121451006753 D-loop; other site 1121451006754 H-loop/switch region; other site 1121451006755 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 1121451006756 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 1121451006757 Glucose inhibited division protein A; Region: GIDA; pfam01134 1121451006758 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 1121451006759 dihydrodipicolinate synthase; Region: dapA; TIGR00674 1121451006760 dimer interface [polypeptide binding]; other site 1121451006761 active site 1121451006762 catalytic residue [active] 1121451006763 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1121451006764 IHF - DNA interface [nucleotide binding]; other site 1121451006765 IHF dimer interface [polypeptide binding]; other site 1121451006766 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 1121451006767 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1121451006768 FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038 1121451006769 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1121451006770 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1121451006771 metal binding site [ion binding]; metal-binding site 1121451006772 active site 1121451006773 I-site; other site 1121451006774 This domain is found in peptide chain release factors; Region: PCRF; smart00937 1121451006775 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 1121451006776 RF-1 domain; Region: RF-1; pfam00472 1121451006777 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 1121451006778 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 1121451006779 putative active site [active] 1121451006780 catalytic triad [active] 1121451006781 putative dimer interface [polypeptide binding]; other site 1121451006782 FOG: CBS domain [General function prediction only]; Region: COG0517 1121451006783 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1121451006784 Transporter associated domain; Region: CorC_HlyC; smart01091 1121451006785 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 1121451006786 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 1121451006787 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 1121451006788 diaminopimelate aminotransferase; Provisional; Region: PRK13983 1121451006789 M20 Peptidases with similarity to acetylornithine deacetylases and succinyl-diaminopimelate desuccinylases; Region: M20_ArgE_DapE_like1; cd05650 1121451006790 metal binding site [ion binding]; metal-binding site 1121451006791 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1121451006792 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 1121451006793 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1121451006794 active site 1121451006795 seryl-tRNA synthetase; Provisional; Region: PRK05431 1121451006796 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 1121451006797 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 1121451006798 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1121451006799 S-adenosylmethionine binding site [chemical binding]; other site 1121451006800 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1121451006801 IHF dimer interface [polypeptide binding]; other site 1121451006802 IHF - DNA interface [nucleotide binding]; other site 1121451006803 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 1121451006804 Yqey-like protein; Region: YqeY; pfam09424 1121451006805 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 1121451006806 MutS domain III; Region: MutS_III; pfam05192 1121451006807 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1121451006808 Walker A/P-loop; other site 1121451006809 ATP binding site [chemical binding]; other site 1121451006810 Q-loop/lid; other site 1121451006811 ABC transporter signature motif; other site 1121451006812 Walker B; other site 1121451006813 D-loop; other site 1121451006814 H-loop/switch region; other site 1121451006815 Smr domain; Region: Smr; pfam01713 1121451006816 DNA primase, catalytic core; Region: dnaG; TIGR01391 1121451006817 CHC2 zinc finger; Region: zf-CHC2; pfam01807 1121451006818 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 1121451006819 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 1121451006820 active site 1121451006821 metal binding site [ion binding]; metal-binding site 1121451006822 interdomain interaction site; other site 1121451006823 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 1121451006824 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 1121451006825 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 1121451006826 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1121451006827 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1121451006828 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1121451006829 DNA binding residues [nucleotide binding] 1121451006830 CobD/Cbib protein; Region: CobD_Cbib; pfam03186 1121451006831 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 1121451006832 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 1121451006833 pyrroline-5-carboxylate reductase; Region: PLN02688 1121451006834 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 1121451006835 active site 1121451006836 multimer interface [polypeptide binding]; other site 1121451006837 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101 1121451006838 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1121451006839 Walker A/P-loop; other site 1121451006840 ATP binding site [chemical binding]; other site 1121451006841 Q-loop/lid; other site 1121451006842 ABC transporter signature motif; other site 1121451006843 Walker B; other site 1121451006844 D-loop; other site 1121451006845 H-loop/switch region; other site 1121451006846 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1121451006847 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574 1121451006848 TM-ABC transporter signature motif; other site 1121451006849 Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325 1121451006850 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 1121451006851 zinc binding site [ion binding]; other site 1121451006852 putative ligand binding site [chemical binding]; other site 1121451006853 Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936 1121451006854 NodB motif; other site 1121451006855 putative active site [active] 1121451006856 putative catalytic site [active] 1121451006857 Zn binding site [ion binding]; other site 1121451006858 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 1121451006859 C-terminal peptidase (prc); Region: prc; TIGR00225 1121451006860 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 1121451006861 protein binding site [polypeptide binding]; other site 1121451006862 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 1121451006863 Catalytic dyad [active] 1121451006864 Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942 1121451006865 Peptidase family M23; Region: Peptidase_M23; pfam01551 1121451006866 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1121451006867 endonuclease III; Region: ENDO3c; smart00478 1121451006868 minor groove reading motif; other site 1121451006869 helix-hairpin-helix signature motif; other site 1121451006870 substrate binding pocket [chemical binding]; other site 1121451006871 active site 1121451006872 ribosomal protein L11 methyltransferase; Reviewed; Region: prmA; PRK00517 1121451006873 S-adenosylmethionine binding site [chemical binding]; other site 1121451006874 Methyltransferase domain; Region: Methyltransf_18; pfam12847 1121451006875 acetylornithine aminotransferase; Provisional; Region: PRK02627 1121451006876 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1121451006877 inhibitor-cofactor binding pocket; inhibition site 1121451006878 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1121451006879 catalytic residue [active] 1121451006880 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 1121451006881 trimer interface [polypeptide binding]; other site 1121451006882 active site 1121451006883 This family is most closely related to the oligosaccharide phosphorylase domain family and other unidentified sequences. Oligosaccharide phosphorylase catalyzes the breakdown of oligosaccharides into glucose-1-phosphate units. They are important...; Region: GT1_Glycogen_Phosphorylase_like; cd04299 1121451006884 putative homodimer interface [polypeptide binding]; other site 1121451006885 putative active site pocket [active] 1121451006886 alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094 1121451006887 Staphylococcal nuclease homologues; Region: SNc; smart00318 1121451006888 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175 1121451006889 Catalytic site; other site 1121451006890 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 1121451006891 4Fe-4S binding domain; Region: Fer4; pfam00037 1121451006892 Conserved region in glutamate synthase; Region: Glu_synthase; pfam01645 1121451006893 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 1121451006894 active site 1121451006895 FMN binding site [chemical binding]; other site 1121451006896 substrate binding site [chemical binding]; other site 1121451006897 3Fe-4S cluster binding site [ion binding]; other site 1121451006898 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 1121451006899 4Fe-4S binding domain; Region: Fer4; cl02805 1121451006900 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 1121451006901 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1121451006902 Glutamate synthase domain 1 [Amino acid transport and metabolism]; Region: GltB; COG0067 1121451006903 Glutamine amidotransferases class-II (Gn-AT)_GlxB-type. GlxB is a glutamine amidotransferase-like protein of unknown function found in bacteria and archaea. GlxB has a structural fold similar to that of other class II glutamine amidotransferases...; Region: GlxB; cd01907 1121451006904 putative active site [active] 1121451006905 Archaeal-type gltB domain. This domain shares sequence similarity with a region of unknown function found in the large subunit of glutamate synthase, which is encoded by gltB and found in most bacteria and eukaryotes. It is predicted to be homologous to...; Region: arch_gltB; cd00981 1121451006906 putative subunit interface; other site 1121451006907 Preprotein translocase subunit; Region: YajC; pfam02699 1121451006908 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 1121451006909 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 1121451006910 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 1121451006911 Protein export membrane protein; Region: SecD_SecF; pfam02355 1121451006912 Aldehyde ferredoxin oxidoreductase, N-terminal domain; Region: AFOR_N; smart00790 1121451006913 Aldehyde:ferredoxin oxidoreductase [Energy production and conversion]; Region: COG2414 1121451006914 Aldehyde ferredoxin oxidoreductase, domains 2 & 3; Region: AFOR_C; pfam01314 1121451006915 4Fe-4S binding domain; Region: Fer4_5; pfam12801 1121451006916 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 1121451006917 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1121451006918 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 1121451006919 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 1121451006920 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 1121451006921 NADP binding site [chemical binding]; other site 1121451006922 active site 1121451006923 putative substrate binding site [chemical binding]; other site 1121451006924 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 1121451006925 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 1121451006926 NAD binding site [chemical binding]; other site 1121451006927 substrate binding site [chemical binding]; other site 1121451006928 homodimer interface [polypeptide binding]; other site 1121451006929 active site 1121451006930 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 1121451006931 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 1121451006932 homotrimer interaction site [polypeptide binding]; other site 1121451006933 putative active site [active] 1121451006934 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1121451006935 anti sigma factor interaction site; other site 1121451006936 regulatory phosphorylation site [posttranslational modification]; other site 1121451006937 Response regulator receiver domain; Region: Response_reg; pfam00072 1121451006938 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121451006939 active site 1121451006940 phosphorylation site [posttranslational modification] 1121451006941 intermolecular recognition site; other site 1121451006942 dimerization interface [polypeptide binding]; other site 1121451006943 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 1121451006944 Histidine kinase; Region: HisKA_2; pfam07568 1121451006945 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1121451006946 ATP binding site [chemical binding]; other site 1121451006947 Mg2+ binding site [ion binding]; other site 1121451006948 G-X-G motif; other site 1121451006949 PilZ domain; Region: PilZ; pfam07238 1121451006950 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1121451006951 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1121451006952 Walker A/P-loop; other site 1121451006953 ATP binding site [chemical binding]; other site 1121451006954 Q-loop/lid; other site 1121451006955 ABC transporter signature motif; other site 1121451006956 Walker B; other site 1121451006957 D-loop; other site 1121451006958 H-loop/switch region; other site 1121451006959 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1121451006960 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1121451006961 dimer interface [polypeptide binding]; other site 1121451006962 conserved gate region; other site 1121451006963 putative PBP binding loops; other site 1121451006964 ABC-ATPase subunit interface; other site 1121451006965 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1121451006966 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1121451006967 substrate binding pocket [chemical binding]; other site 1121451006968 membrane-bound complex binding site; other site 1121451006969 hinge residues; other site 1121451006970 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1121451006971 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1121451006972 substrate binding pocket [chemical binding]; other site 1121451006973 membrane-bound complex binding site; other site 1121451006974 hinge residues; other site 1121451006975 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1121451006976 dimer interface [polypeptide binding]; other site 1121451006977 conserved gate region; other site 1121451006978 putative PBP binding loops; other site 1121451006979 ABC-ATPase subunit interface; other site 1121451006980 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1121451006981 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1121451006982 Walker A/P-loop; other site 1121451006983 ATP binding site [chemical binding]; other site 1121451006984 Q-loop/lid; other site 1121451006985 ABC transporter signature motif; other site 1121451006986 Walker B; other site 1121451006987 D-loop; other site 1121451006988 H-loop/switch region; other site 1121451006989 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1121451006990 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121451006991 active site 1121451006992 phosphorylation site [posttranslational modification] 1121451006993 intermolecular recognition site; other site 1121451006994 dimerization interface [polypeptide binding]; other site 1121451006995 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1121451006996 dimer interface [polypeptide binding]; other site 1121451006997 phosphorylation site [posttranslational modification] 1121451006998 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1121451006999 ATP binding site [chemical binding]; other site 1121451007000 Mg2+ binding site [ion binding]; other site 1121451007001 G-X-G motif; other site 1121451007002 Response regulator receiver domain; Region: Response_reg; pfam00072 1121451007003 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121451007004 active site 1121451007005 phosphorylation site [posttranslational modification] 1121451007006 intermolecular recognition site; other site 1121451007007 dimerization interface [polypeptide binding]; other site 1121451007008 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1121451007009 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1121451007010 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 1121451007011 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 1121451007012 active site 1121451007013 metal binding site [ion binding]; metal-binding site 1121451007014 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 1121451007015 Membrane-bound lytic murein transglycosylase [Cell envelope biogenesis, outer membrane]; Region: MltA; COG2821 1121451007016 MltA specific insert domain; Region: MltA; smart00925 1121451007017 3D domain; Region: 3D; pfam06725 1121451007018 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1121451007019 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1121451007020 active site 1121451007021 Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294 1121451007022 active site 1121451007023 substrate binding pocket [chemical binding]; other site 1121451007024 dimer interface [polypeptide binding]; other site 1121451007025 allantoate amidohydrolase; Reviewed; Region: PRK09290 1121451007026 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 1121451007027 active site 1121451007028 metal binding site [ion binding]; metal-binding site 1121451007029 dimer interface [polypeptide binding]; other site 1121451007030 DctM-like transporters; Region: DctM; pfam06808 1121451007031 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 1121451007032 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290 1121451007033 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 1121451007034 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 1121451007035 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1121451007036 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1121451007037 non-specific DNA binding site [nucleotide binding]; other site 1121451007038 salt bridge; other site 1121451007039 sequence-specific DNA binding site [nucleotide binding]; other site 1121451007040 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 1121451007041 Peptidase family U32; Region: Peptidase_U32; pfam01136 1121451007042 Peptidase family U32; Region: Peptidase_U32; cl03113 1121451007043 dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054 1121451007044 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218 1121451007045 FAD binding pocket [chemical binding]; other site 1121451007046 FAD binding motif [chemical binding]; other site 1121451007047 phosphate binding motif [ion binding]; other site 1121451007048 beta-alpha-beta structure motif; other site 1121451007049 NAD binding pocket [chemical binding]; other site 1121451007050 Iron coordination center [ion binding]; other site 1121451007051 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 1121451007052 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 1121451007053 heterodimer interface [polypeptide binding]; other site 1121451007054 active site 1121451007055 FMN binding site [chemical binding]; other site 1121451007056 homodimer interface [polypeptide binding]; other site 1121451007057 substrate binding site [chemical binding]; other site 1121451007058 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1121451007059 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1121451007060 ATP binding site [chemical binding]; other site 1121451007061 putative Mg++ binding site [ion binding]; other site 1121451007062 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1121451007063 nucleotide binding region [chemical binding]; other site 1121451007064 ATP-binding site [chemical binding]; other site 1121451007065 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1121451007066 dimerization interface [polypeptide binding]; other site 1121451007067 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1121451007068 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1121451007069 dimer interface [polypeptide binding]; other site 1121451007070 putative CheW interface [polypeptide binding]; other site 1121451007071 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1121451007072 TPR motif; other site 1121451007073 TPR repeat; Region: TPR_11; pfam13414 1121451007074 binding surface 1121451007075 trigger factor; Region: tig; TIGR00115 1121451007076 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 1121451007077 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 1121451007078 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 1121451007079 oligomer interface [polypeptide binding]; other site 1121451007080 active site residues [active] 1121451007081 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 1121451007082 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 1121451007083 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 1121451007084 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1121451007085 Walker A motif; other site 1121451007086 ATP binding site [chemical binding]; other site 1121451007087 Walker B motif; other site 1121451007088 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1121451007089 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1121451007090 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1121451007091 PAS fold; Region: PAS_3; pfam08447 1121451007092 putative active site [active] 1121451007093 heme pocket [chemical binding]; other site 1121451007094 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 1121451007095 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1121451007096 putative active site [active] 1121451007097 heme pocket [chemical binding]; other site 1121451007098 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1121451007099 dimer interface [polypeptide binding]; other site 1121451007100 phosphorylation site [posttranslational modification] 1121451007101 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1121451007102 ATP binding site [chemical binding]; other site 1121451007103 Mg2+ binding site [ion binding]; other site 1121451007104 G-X-G motif; other site 1121451007105 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 1121451007106 Found in ATP-dependent protease La (LON); Region: LON; smart00464 1121451007107 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1121451007108 Walker A motif; other site 1121451007109 ATP binding site [chemical binding]; other site 1121451007110 Walker B motif; other site 1121451007111 arginine finger; other site 1121451007112 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 1121451007113 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1121451007114 Beta-lactamase; Region: Beta-lactamase; pfam00144 1121451007115 Alkaline phosphatase [Inorganic ion transport and metabolism]; Region: PhoA; COG1785 1121451007116 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cl15837 1121451007117 dimer interface [polypeptide binding]; other site 1121451007118 active site 1121451007119 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cl15837 1121451007120 YibE/F-like protein; Region: YibE_F; pfam07907 1121451007121 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1121451007122 Peptidase family M23; Region: Peptidase_M23; pfam01551 1121451007123 Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409 1121451007124 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 1121451007125 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 1121451007126 Nickel-dependent hydrogenase; Region: NiFeSe_Hases; pfam00374 1121451007127 Hydrogenase specific C-terminal endopeptidases, also called Hydrogen Maturation Proteases (H2MP). These enzymes belong to the peptidase family M52. Maturation of [FeNi] hydrogenases includes formation of the nickel metallocenter, proteolytic processing...; Region: H2MP; cl00477 1121451007128 nickel binding site [ion binding]; other site 1121451007129 FOG: CBS domain [General function prediction only]; Region: COG0517 1121451007130 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 1121451007131 Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518 1121451007132 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1121451007133 S-adenosylmethionine binding site [chemical binding]; other site 1121451007134 Domain of unknown function (DUF368); Region: DUF368; pfam04018 1121451007135 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 1121451007136 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 1121451007137 Walker A motif; other site 1121451007138 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 1121451007139 Septum formation initiator; Region: DivIC; pfam04977 1121451007140 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 1121451007141 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1121451007142 TPR motif; other site 1121451007143 binding surface 1121451007144 Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354 1121451007145 AMP binding site [chemical binding]; other site 1121451007146 metal binding site [ion binding]; metal-binding site 1121451007147 active site 1121451007148 UGMP family protein; Validated; Region: PRK09604 1121451007149 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 1121451007150 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1121451007151 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1121451007152 catalytic residues [active] 1121451007153 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 1121451007154 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1121451007155 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1121451007156 outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302 1121451007157 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cl10029 1121451007158 elongation factor G; Reviewed; Region: PRK12740 1121451007159 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 1121451007160 G1 box; other site 1121451007161 putative GEF interaction site [polypeptide binding]; other site 1121451007162 GTP/Mg2+ binding site [chemical binding]; other site 1121451007163 Switch I region; other site 1121451007164 G2 box; other site 1121451007165 G3 box; other site 1121451007166 Switch II region; other site 1121451007167 G4 box; other site 1121451007168 G5 box; other site 1121451007169 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 1121451007170 Elongation Factor G-like domain IV. This family includes the translational elongation factor termed EF-2 (for Archaea and Eukarya) and EF-G (for Bacteria), ribosomal protection proteins that mediate tetracycline resistance and, an evolutionarily...; Region: EFG_like_IV; cd01680 1121451007171 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 1121451007172 Uncharacterized protein conserved in bacteria (DUF2062); Region: DUF2062; pfam09835 1121451007173 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 1121451007174 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1121451007175 putative binding surface; other site 1121451007176 active site 1121451007177 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 1121451007178 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1121451007179 ATP binding site [chemical binding]; other site 1121451007180 Mg2+ binding site [ion binding]; other site 1121451007181 G-X-G motif; other site 1121451007182 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 1121451007183 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 1121451007184 Methyltransferase, chemotaxis proteins; Region: MeTrc; smart00138 1121451007185 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 1121451007186 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 1121451007187 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121451007188 active site 1121451007189 phosphorylation site [posttranslational modification] 1121451007190 intermolecular recognition site; other site 1121451007191 dimerization interface [polypeptide binding]; other site 1121451007192 CheB methylesterase; Region: CheB_methylest; pfam01339 1121451007193 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 1121451007194 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1121451007195 putative active site [active] 1121451007196 putative metal binding site [ion binding]; other site 1121451007197 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1121451007198 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1121451007199 putative active site [active] 1121451007200 heme pocket [chemical binding]; other site 1121451007201 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1121451007202 ATP binding site [chemical binding]; other site 1121451007203 Mg2+ binding site [ion binding]; other site 1121451007204 G-X-G motif; other site 1121451007205 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 1121451007206 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121451007207 active site 1121451007208 phosphorylation site [posttranslational modification] 1121451007209 intermolecular recognition site; other site 1121451007210 dimerization interface [polypeptide binding]; other site 1121451007211 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1121451007212 Walker A motif; other site 1121451007213 ATP binding site [chemical binding]; other site 1121451007214 Walker B motif; other site 1121451007215 arginine finger; other site 1121451007216 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1121451007217 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 1121451007218 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1121451007219 acyl-activating enzyme (AAE) consensus motif; other site 1121451007220 active site 1121451007221 AMP binding site [chemical binding]; other site 1121451007222 CoA binding site [chemical binding]; other site 1121451007223 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 1121451007224 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 1121451007225 Walker A/P-loop; other site 1121451007226 ATP binding site [chemical binding]; other site 1121451007227 Q-loop/lid; other site 1121451007228 ABC transporter signature motif; other site 1121451007229 Walker B; other site 1121451007230 D-loop; other site 1121451007231 H-loop/switch region; other site 1121451007232 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 1121451007233 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_1; cd06334 1121451007234 putative ligand binding site [chemical binding]; other site 1121451007235 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 1121451007236 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 1121451007237 TM-ABC transporter signature motif; other site 1121451007238 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1121451007239 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 1121451007240 TM-ABC transporter signature motif; other site 1121451007241 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 1121451007242 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 1121451007243 acyl-activating enzyme (AAE) consensus motif; other site 1121451007244 putative AMP binding site [chemical binding]; other site 1121451007245 putative active site [active] 1121451007246 putative CoA binding site [chemical binding]; other site 1121451007247 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 1121451007248 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 1121451007249 Walker A/P-loop; other site 1121451007250 ATP binding site [chemical binding]; other site 1121451007251 Q-loop/lid; other site 1121451007252 ABC transporter signature motif; other site 1121451007253 Walker B; other site 1121451007254 D-loop; other site 1121451007255 H-loop/switch region; other site 1121451007256 FOG: CBS domain [General function prediction only]; Region: COG0517 1121451007257 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 1121451007258 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 1121451007259 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 1121451007260 classical (c) SDRs; Region: SDR_c; cd05233 1121451007261 NAD(P) binding site [chemical binding]; other site 1121451007262 active site 1121451007263 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1121451007264 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1121451007265 Histidine kinase; Region: HisKA_3; pfam07730 1121451007266 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 1121451007267 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1121451007268 ATP binding site [chemical binding]; other site 1121451007269 Mg2+ binding site [ion binding]; other site 1121451007270 G-X-G motif; other site 1121451007271 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1121451007272 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121451007273 active site 1121451007274 phosphorylation site [posttranslational modification] 1121451007275 intermolecular recognition site; other site 1121451007276 dimerization interface [polypeptide binding]; other site 1121451007277 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1121451007278 DNA binding residues [nucleotide binding] 1121451007279 dimerization interface [polypeptide binding]; other site 1121451007280 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 1121451007281 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 1121451007282 4Fe-4S binding domain; Region: Fer4; pfam00037 1121451007283 Nitroreductase family. Members of this family utilize FMN as a cofactor. This family is involved in the reduction of flavin or nitroaromatic compounds by using NAD(P)H as electron donor in a obligatory two-electron transfer. Nitrogenase is homodimer; Region: NADH_nitroreductase; cd02143 1121451007284 putative FMN binding site [chemical binding]; other site 1121451007285 Transcriptional regulator PadR-like family; Region: PadR; cl17335 1121451007286 Predicted transcriptional regulators [Transcription]; Region: COG1695 1121451007287 methanogenesis imperfect marker protein 11; Region: methan_mark_11; TIGR03280 1121451007288 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1121451007289 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1121451007290 substrate binding pocket [chemical binding]; other site 1121451007291 membrane-bound complex binding site; other site 1121451007292 hinge residues; other site 1121451007293 TRAP-type mannitol/chloroaromatic compound transport system, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT1; COG4663 1121451007294 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 1121451007295 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; cl01181 1121451007296 TRAP-type mannitol/chloroaromatic compound transport system, large permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT3; COG4664 1121451007297 DctM-like transporters; Region: DctM; pfam06808 1121451007298 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 1121451007299 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 1121451007300 GAF domain; Region: GAF; cl17456 1121451007301 Histidine kinase; Region: His_kinase; pfam06580 1121451007302 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1121451007303 ATP binding site [chemical binding]; other site 1121451007304 Mg2+ binding site [ion binding]; other site 1121451007305 G-X-G motif; other site 1121451007306 putative two-component response-regulatory protein YehT; Provisional; Region: PRK11697 1121451007307 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121451007308 active site 1121451007309 phosphorylation site [posttranslational modification] 1121451007310 intermolecular recognition site; other site 1121451007311 dimerization interface [polypeptide binding]; other site 1121451007312 LytTr DNA-binding domain; Region: LytTR; smart00850 1121451007313 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1121451007314 Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093 1121451007315 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1121451007316 non-specific DNA binding site [nucleotide binding]; other site 1121451007317 salt bridge; other site 1121451007318 sequence-specific DNA binding site [nucleotide binding]; other site 1121451007319 Plasmid maintenance system killer protein; Region: Plasmid_killer; cl01422 1121451007320 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 1121451007321 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 1121451007322 Walker A/P-loop; other site 1121451007323 ATP binding site [chemical binding]; other site 1121451007324 Q-loop/lid; other site 1121451007325 ABC transporter signature motif; other site 1121451007326 Walker B; other site 1121451007327 D-loop; other site 1121451007328 H-loop/switch region; other site 1121451007329 TOBE domain; Region: TOBE_2; pfam08402 1121451007330 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 1121451007331 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1121451007332 dimer interface [polypeptide binding]; other site 1121451007333 conserved gate region; other site 1121451007334 putative PBP binding loops; other site 1121451007335 ABC-ATPase subunit interface; other site 1121451007336 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1121451007337 dimer interface [polypeptide binding]; other site 1121451007338 conserved gate region; other site 1121451007339 putative PBP binding loops; other site 1121451007340 ABC-ATPase subunit interface; other site 1121451007341 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 1121451007342 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 1121451007343 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 1121451007344 sodium--glutamate symport carrier (gltS); Region: gltS; TIGR00210 1121451007345 Domain of unknown function (DUF4172); Region: DUF4172; pfam13776 1121451007346 Domain of unknown function (DUF4172); Region: DUF4172; pfam13776 1121451007347 CRISPR/Cas system-associated RAMP superfamily protein Cas6f; Region: Cas6_I-F; cd09739 1121451007348 CRISPR/Cas system-associated RAMP superfamily protein Csy3; Region: Csy3_I-F; cd09737 1121451007349 CRISPR/Cas system-associated RAMP superfamily protein Csy2; Region: Csy2_I-F; cd09736 1121451007350 CRISPR/Cas system-associated protein Csy1; Region: Csy1_I-F; cl09829 1121451007351 CRISPR/Cas system-associated protein Cas3/Cas2; Region: Cas3_Cas2_I-F; cd09673 1121451007352 CRISPR-associated helicase Cas3, subtype I-F/YPEST; Region: cas3_yersinia; TIGR02562 1121451007353 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cl00656 1121451007354 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1121451007355 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1121451007356 putative substrate translocation pore; other site 1121451007357 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 1121451007358 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 1121451007359 Hemerythrin; Region: Hemerythrin; cd12107 1121451007360 Fe binding site [ion binding]; other site 1121451007361 FtsH Extracellular; Region: FtsH_ext; pfam06480 1121451007362 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 1121451007363 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1121451007364 Walker A motif; other site 1121451007365 ATP binding site [chemical binding]; other site 1121451007366 Walker B motif; other site 1121451007367 arginine finger; other site 1121451007368 Peptidase family M41; Region: Peptidase_M41; pfam01434 1121451007369 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 1121451007370 dihydropteroate synthase; Region: DHPS; TIGR01496 1121451007371 substrate binding pocket [chemical binding]; other site 1121451007372 dimer interface [polypeptide binding]; other site 1121451007373 inhibitor binding site; inhibition site 1121451007374 Uncharacterized conserved protein [Function unknown]; Region: COG1624 1121451007375 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 1121451007376 YbbR-like protein; Region: YbbR; pfam07949 1121451007377 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14314 1121451007378 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 1121451007379 active site 1121451007380 substrate binding site [chemical binding]; other site 1121451007381 metal binding site [ion binding]; metal-binding site 1121451007382 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 1121451007383 active site 1121451007384 tetramer interface; other site 1121451007385 Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198 1121451007386 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1121451007387 ATP binding site [chemical binding]; other site 1121451007388 putative Mg++ binding site [ion binding]; other site 1121451007389 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1121451007390 ATP-binding site [chemical binding]; other site 1121451007391 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1121451007392 anti sigma factor interaction site; other site 1121451007393 regulatory phosphorylation site [posttranslational modification]; other site 1121451007394 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840 1121451007395 Smr domain; Region: Smr; pfam01713 1121451007396 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 1121451007397 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 1121451007398 Walker A/P-loop; other site 1121451007399 ATP binding site [chemical binding]; other site 1121451007400 Q-loop/lid; other site 1121451007401 ABC transporter signature motif; other site 1121451007402 Walker B; other site 1121451007403 D-loop; other site 1121451007404 H-loop/switch region; other site 1121451007405 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 1121451007406 Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458 1121451007407 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307 1121451007408 Uncharacterized Fe-S protein [Energy production and conversion]; Region: COG1600 1121451007409 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1121451007410 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1121451007411 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 1121451007412 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 1121451007413 CoA-ligase; Region: Ligase_CoA; pfam00549 1121451007414 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 1121451007415 CoA binding domain; Region: CoA_binding; pfam02629 1121451007416 CoA-ligase; Region: Ligase_CoA; pfam00549 1121451007417 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 1121451007418 multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase; Reviewed; Region: cca; PRK10885 1121451007419 active site 1121451007420 NTP binding site [chemical binding]; other site 1121451007421 metal binding triad [ion binding]; metal-binding site 1121451007422 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 1121451007423 Uncharacterized conserved protein [Function unknown]; Region: COG0398 1121451007424 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1121451007425 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1121451007426 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1121451007427 ligand binding site [chemical binding]; other site 1121451007428 flexible hinge region; other site 1121451007429 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1121451007430 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1121451007431 ligand binding site [chemical binding]; other site 1121451007432 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 1121451007433 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 1121451007434 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 1121451007435 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 1121451007436 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl17700 1121451007437 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 1121451007438 putative exosortase-associated protein, TIGR04073 family; Region: exo_TIGR04073 1121451007439 Thioredoxin; Region: Thioredoxin_4; pfam13462 1121451007440 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 1121451007441 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1121451007442 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1121451007443 S-adenosylmethionine binding site [chemical binding]; other site 1121451007444 NCAIR mutase (PurE)-related proteins [General function prediction only]; Region: COG1691 1121451007445 AIR carboxylase; Region: AIRC; smart01001 1121451007446 hypothetical protein; Provisional; Region: PRK04194 1121451007447 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 1121451007448 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 1121451007449 NAD binding site [chemical binding]; other site 1121451007450 homodimer interface [polypeptide binding]; other site 1121451007451 active site 1121451007452 substrate binding site [chemical binding]; other site 1121451007453 conserved hypothetical protein; Region: TIGR02231 1121451007454 N-terminal domain of unknown function (DUF4140); Region: DUF4140; pfam13600 1121451007455 Domain of unknown function (DUF4139); Region: DUF4139; pfam13598 1121451007456 Long-chain fatty acid transport protein [Lipid metabolism]; Region: FadL; COG2067 1121451007457 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 1121451007458 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1121451007459 RNA binding surface [nucleotide binding]; other site 1121451007460 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1121451007461 S-adenosylmethionine binding site [chemical binding]; other site 1121451007462 threonine synthase; Validated; Region: PRK06260 1121451007463 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 1121451007464 homodimer interface [polypeptide binding]; other site 1121451007465 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1121451007466 catalytic residue [active] 1121451007467 Protein of unknown function (DUF456); Region: DUF456; pfam04306 1121451007468 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 1121451007469 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1121451007470 acyl-activating enzyme (AAE) consensus motif; other site 1121451007471 AMP binding site [chemical binding]; other site 1121451007472 active site 1121451007473 CoA binding site [chemical binding]; other site 1121451007474 replicative DNA helicase; Region: DnaB; TIGR00665 1121451007475 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 1121451007476 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 1121451007477 Walker A motif; other site 1121451007478 ATP binding site [chemical binding]; other site 1121451007479 Walker B motif; other site 1121451007480 DNA binding loops [nucleotide binding] 1121451007481 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 1121451007482 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 1121451007483 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 1121451007484 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 1121451007485 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 1121451007486 Enoyl-[acyl-carrier-protein]; Region: FabI; COG0623 1121451007487 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 1121451007488 NAD binding site [chemical binding]; other site 1121451007489 homotetramer interface [polypeptide binding]; other site 1121451007490 homodimer interface [polypeptide binding]; other site 1121451007491 substrate binding site [chemical binding]; other site 1121451007492 active site 1121451007493 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 1121451007494 ATP binding site [chemical binding]; other site 1121451007495 active site 1121451007496 substrate binding site [chemical binding]; other site 1121451007497 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 1121451007498 histidinol dehydrogenase; Region: hisD; TIGR00069 1121451007499 NAD binding site [chemical binding]; other site 1121451007500 dimerization interface [polypeptide binding]; other site 1121451007501 product binding site; other site 1121451007502 substrate binding site [chemical binding]; other site 1121451007503 zinc binding site [ion binding]; other site 1121451007504 catalytic residues [active] 1121451007505 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 1121451007506 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 1121451007507 GIY-YIG motif/motif A; other site 1121451007508 active site 1121451007509 catalytic site [active] 1121451007510 putative DNA binding site [nucleotide binding]; other site 1121451007511 metal binding site [ion binding]; metal-binding site 1121451007512 UvrB/uvrC motif; Region: UVR; pfam02151 1121451007513 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 1121451007514 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 1121451007515 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1121451007516 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1121451007517 3-polyprenyl-4-hydroxybenzoate decarboxylase [Coenzyme metabolism]; Region: UbiX; COG0163 1121451007518 Flavoprotein; Region: Flavoprotein; pfam02441 1121451007519 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 1121451007520 ATP-grasp domain; Region: ATP-grasp; pfam02222 1121451007521 Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757 1121451007522 PII-like signaling protein [Signal transduction mechanisms]; Region: COG1993 1121451007523 Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239 1121451007524 Adenylyl cyclase (AC) class IV-like, a subgroup of the CYTH-like superfamily; Region: CYTH-like_AC_IV-like; cd07890 1121451007525 putative active site [active] 1121451007526 putative metal binding residues [ion binding]; other site 1121451007527 signature motif; other site 1121451007528 putative triphosphate binding site [ion binding]; other site 1121451007529 dimer interface [polypeptide binding]; other site 1121451007530 Uncharacterized conserved protein [Function unknown]; Region: COG2127 1121451007531 ATP-dependent Clp protease ATP-binding subunit clpA; Region: ClpA; TIGR02639 1121451007532 Clp amino terminal domain; Region: Clp_N; pfam02861 1121451007533 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1121451007534 Walker A motif; other site 1121451007535 ATP binding site [chemical binding]; other site 1121451007536 Walker B motif; other site 1121451007537 arginine finger; other site 1121451007538 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1121451007539 Walker A motif; other site 1121451007540 ATP binding site [chemical binding]; other site 1121451007541 Walker B motif; other site 1121451007542 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1121451007543 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1121451007544 TPR motif; other site 1121451007545 binding surface 1121451007546 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1121451007547 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1121451007548 binding surface 1121451007549 TPR motif; other site 1121451007550 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1121451007551 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1121451007552 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1121451007553 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1121451007554 binding surface 1121451007555 TPR motif; other site 1121451007556 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1121451007557 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1121451007558 Chemotaxis phosphatase, CheZ; Region: CheZ; cl01219 1121451007559 NIL domain; Region: NIL; pfam09383 1121451007560 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 1121451007561 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 1121451007562 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 1121451007563 Tetratricopeptide repeat; Region: TPR_6; pfam13174 1121451007564 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 1121451007565 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 1121451007566 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 1121451007567 lipoprotein signal peptidase; Provisional; Region: PRK14787 1121451007568 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 1121451007569 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1121451007570 active site 1121451007571 HIGH motif; other site 1121451007572 nucleotide binding site [chemical binding]; other site 1121451007573 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1121451007574 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 1121451007575 active site 1121451007576 KMSKS motif; other site 1121451007577 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 1121451007578 tRNA binding surface [nucleotide binding]; other site 1121451007579 anticodon binding site; other site 1121451007580 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1121451007581 Protein of unknown function (DUF493); Region: DUF493; pfam04359 1121451007582 N-terminal putative catalytic domain of mainly uncharacterized prokaryotic proteins similar to archaeal thermoactive amylopullulanases; glycoside hydrolase family 57 (GH57); Region: GH57N_APU_like_1; cd10797 1121451007583 Glycosyl hydrolase family 57; Region: Glyco_hydro_57; pfam03065 1121451007584 active site 1121451007585 catalytic site [active] 1121451007586 Domain of unknown function (DUF3536); Region: DUF3536; pfam12055 1121451007587 Metal-dependent hydrolases of the beta-lactamase superfamily II [General function prediction only]; Region: COG1237 1121451007588 putative alpha-isopropylmalate/homocitrate synthase family transferase; Provisional; Region: PRK12344 1121451007589 Desulfobacterium autotrophicum LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA3; cd07941 1121451007590 active site 1121451007591 catalytic residues [active] 1121451007592 metal binding site [ion binding]; metal-binding site 1121451007593 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 1121451007594 aspartate kinase; Reviewed; Region: PRK06635 1121451007595 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 1121451007596 putative nucleotide binding site [chemical binding]; other site 1121451007597 putative catalytic residues [active] 1121451007598 putative Mg ion binding site [ion binding]; other site 1121451007599 putative aspartate binding site [chemical binding]; other site 1121451007600 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 1121451007601 putative allosteric regulatory site; other site 1121451007602 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 1121451007603 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 1121451007604 FOG: CBS domain [General function prediction only]; Region: COG0517 1121451007605 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 1121451007606 putative carbohydrate kinase; Provisional; Region: PRK10565 1121451007607 YjeF-related protein N-terminus; Region: YjeF_N; pfam03853 1121451007608 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 1121451007609 putative substrate binding site [chemical binding]; other site 1121451007610 putative ATP binding site [chemical binding]; other site 1121451007611 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK14657 1121451007612 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003 1121451007613 active site 1121451007614 hydrophilic channel; other site 1121451007615 dimerization interface [polypeptide binding]; other site 1121451007616 catalytic residues [active] 1121451007617 active site lid [active] 1121451007618 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 1121451007619 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1121451007620 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1121451007621 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 1121451007622 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 1121451007623 putative CheA interaction surface; other site 1121451007624 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 1121451007625 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; pfam02559 1121451007626 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1121451007627 ATP binding site [chemical binding]; other site 1121451007628 putative Mg++ binding site [ion binding]; other site 1121451007629 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1121451007630 nucleotide binding region [chemical binding]; other site 1121451007631 ATP-binding site [chemical binding]; other site 1121451007632 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 1121451007633 SurA N-terminal domain; Region: SurA_N_3; cl07813 1121451007634 peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059 1121451007635 SurA N-terminal domain; Region: SurA_N; pfam09312 1121451007636 PPIC-type PPIASE domain; Region: Rotamase_2; cl08278 1121451007637 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1121451007638 non-specific DNA binding site [nucleotide binding]; other site 1121451007639 salt bridge; other site 1121451007640 sequence-specific DNA binding site [nucleotide binding]; other site 1121451007641 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 1121451007642 Recombination protein O N terminal; Region: RecO_N; pfam11967 1121451007643 DNA repair protein RecO; Region: reco; TIGR00613 1121451007644 Recombination protein O C terminal; Region: RecO_C; pfam02565 1121451007645 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 1121451007646 dimer interface [polypeptide binding]; other site 1121451007647 motif 1; other site 1121451007648 active site 1121451007649 motif 2; other site 1121451007650 motif 3; other site 1121451007651 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 1121451007652 Filamentous haemagglutinin family outer membrane protein; Region: DUF3739; pfam12545 1121451007653 DALR anticodon binding domain; Region: DALR_1; pfam05746 1121451007654 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 1121451007655 potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496 1121451007656 TrkA-N domain; Region: TrkA_N; pfam02254 1121451007657 TrkA-C domain; Region: TrkA_C; pfam02080 1121451007658 TrkA-N domain; Region: TrkA_N; pfam02254 1121451007659 TrkA-C domain; Region: TrkA_C; pfam02080 1121451007660 Cation transport protein; Region: TrkH; cl17365 1121451007661 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 1121451007662 Aspartate oxidase [Coenzyme metabolism]; Region: NadB; COG0029 1121451007663 L-aspartate oxidase; Provisional; Region: PRK06175 1121451007664 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1121451007665 quinolinate synthetase; Provisional; Region: PRK09375 1121451007666 Nicotinate-nucleotide pyrophosphorylase [Coenzyme metabolism]; Region: NadC; COG0157 1121451007667 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 1121451007668 dimerization interface [polypeptide binding]; other site 1121451007669 active site 1121451007670 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 1121451007671 MgtE intracellular N domain; Region: MgtE_N; smart00924 1121451007672 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 1121451007673 Divalent cation transporter; Region: MgtE; pfam01769 1121451007674 adenylate kinase; Provisional; Region: PRK14529 1121451007675 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 1121451007676 AMP-binding site [chemical binding]; other site 1121451007677 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 1121451007678 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 1121451007679 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 1121451007680 Ligand Binding Site [chemical binding]; other site 1121451007681 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 1121451007682 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 1121451007683 tRNA; other site 1121451007684 putative tRNA binding site [nucleotide binding]; other site 1121451007685 putative NADP binding site [chemical binding]; other site 1121451007686 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 1121451007687 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 1121451007688 Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme metabolism]; Region: CysG; COG1648 1121451007689 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 1121451007690 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 1121451007691 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1121451007692 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4641 1121451007693 DUF based on E. rectale Gene description (DUF3880); Region: DUF3880; pfam12996 1121451007694 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 1121451007695 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 1121451007696 Methyltransferase, chemotaxis proteins; Region: MeTrc; smart00138 1121451007697 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 1121451007698 HDOD domain; Region: HDOD; pfam08668 1121451007699 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1121451007700 Zn2+ binding site [ion binding]; other site 1121451007701 Mg2+ binding site [ion binding]; other site 1121451007702 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1121451007703 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1121451007704 putative active site [active] 1121451007705 heme pocket [chemical binding]; other site 1121451007706 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1121451007707 dimer interface [polypeptide binding]; other site 1121451007708 phosphorylation site [posttranslational modification] 1121451007709 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1121451007710 ATP binding site [chemical binding]; other site 1121451007711 Mg2+ binding site [ion binding]; other site 1121451007712 G-X-G motif; other site 1121451007713 recombination factor protein RarA; Reviewed; Region: PRK13342 1121451007714 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1121451007715 Walker A motif; other site 1121451007716 ATP binding site [chemical binding]; other site 1121451007717 Walker B motif; other site 1121451007718 arginine finger; other site 1121451007719 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 1121451007720 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 1121451007721 RNA methyltransferase, RsmE family; Region: TIGR00046 1121451007722 diaminopimelate decarboxylase; Region: lysA; TIGR01048 1121451007723 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 1121451007724 active site 1121451007725 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1121451007726 substrate binding site [chemical binding]; other site 1121451007727 catalytic residues [active] 1121451007728 dimer interface [polypeptide binding]; other site 1121451007729 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 1121451007730 MutS domain I; Region: MutS_I; pfam01624 1121451007731 MutS domain II; Region: MutS_II; pfam05188 1121451007732 MutS domain III; Region: MutS_III; pfam05192 1121451007733 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 1121451007734 Walker A/P-loop; other site 1121451007735 ATP binding site [chemical binding]; other site 1121451007736 Q-loop/lid; other site 1121451007737 ABC transporter signature motif; other site 1121451007738 Walker B; other site 1121451007739 D-loop; other site 1121451007740 H-loop/switch region; other site 1121451007741 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1121451007742 TPR motif; other site 1121451007743 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1121451007744 binding surface 1121451007745 TPR repeat; Region: TPR_11; pfam13414 1121451007746 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1121451007747 binding surface 1121451007748 TPR motif; other site 1121451007749 Tfp pilus assembly protein PilF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilF; COG3063 1121451007750 Protein of unknown function (DUF1049); Region: DUF1049; pfam06305 1121451007751 FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275 1121451007752 nucleotide binding site/active site [active] 1121451007753 HIT family signature motif; other site 1121451007754 catalytic residue [active] 1121451007755 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 1121451007756 DHH family; Region: DHH; pfam01368 1121451007757 DHHA1 domain; Region: DHHA1; pfam02272 1121451007758 FOG: CBS domain [General function prediction only]; Region: COG0517 1121451007759 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 1121451007760 tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617 1121451007761 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 1121451007762 active site 1121451007763 NTP binding site [chemical binding]; other site 1121451007764 metal binding triad [ion binding]; metal-binding site 1121451007765 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 1121451007766 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 1121451007767 active site 1121451007768 Int/Topo IB signature motif; other site 1121451007769 LL-diaminopimelate aminotransferase; Provisional; Region: PRK09276 1121451007770 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1121451007771 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1121451007772 homodimer interface [polypeptide binding]; other site 1121451007773 catalytic residue [active] 1121451007774 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 1121451007775 catalytic center binding site [active] 1121451007776 ATP binding site [chemical binding]; other site 1121451007777 Ribosomal protein L24e/L24 is a ribosomal protein found in eukaryotes (L24) and in archaea (L24e, distinct from archaeal L24). L24e/L24 is located on the surface of the large subunit, adjacent to proteins L14 and L3, and near the translation factor...; Region: Ribosomal_L24e_L24; cl00909 1121451007778 Class I aldolases; Region: Aldolase_Class_I; cl17187 1121451007779 catalytic residue [active] 1121451007780 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 1121451007781 DsrE/DsrF-like family; Region: DrsE; cl00672 1121451007782 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 1121451007783 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1121451007784 catalytic residue [active] 1121451007785 Staphylococcal nuclease homologue; Region: SNase; pfam00565 1121451007786 Catalytic site; other site 1121451007787 Preprotein translocase SecG subunit; Region: SecG; pfam03840 1121451007788 triosephosphate isomerase; Provisional; Region: PRK14565 1121451007789 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 1121451007790 substrate binding site [chemical binding]; other site 1121451007791 dimer interface [polypeptide binding]; other site 1121451007792 catalytic triad [active] 1121451007793 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 1121451007794 Phosphoglycerate kinase; Region: PGK; pfam00162 1121451007795 substrate binding site [chemical binding]; other site 1121451007796 hinge regions; other site 1121451007797 ADP binding site [chemical binding]; other site 1121451007798 catalytic site [active] 1121451007799 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 1121451007800 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1121451007801 Coenzyme A binding pocket [chemical binding]; other site 1121451007802 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 1121451007803 isopentenyl-diphosphate delta-isomerase, type 1; Region: IPP_isom_1; TIGR02150 1121451007804 nudix motif; other site 1121451007805 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1121451007806 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 1121451007807 active site 1121451007808 dimerization interface [polypeptide binding]; other site 1121451007809 rod shape-determining protein MreB; Provisional; Region: PRK13930 1121451007810 MreB and similar proteins; Region: MreB_like; cd10225 1121451007811 nucleotide binding site [chemical binding]; other site 1121451007812 Mg binding site [ion binding]; other site 1121451007813 putative protofilament interaction site [polypeptide binding]; other site 1121451007814 RodZ interaction site [polypeptide binding]; other site 1121451007815 GAF domain; Region: GAF; pfam01590 1121451007816 GAF domain; Region: GAF_2; pfam13185 1121451007817 GAF domain; Region: GAF_3; pfam13492 1121451007818 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 1121451007819 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 1121451007820 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1121451007821 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1121451007822 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1121451007823 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 1121451007824 molybdopterin cofactor binding site; other site 1121451007825 4Fe-4S dicluster domain; Region: Fer4_11; pfam13247 1121451007826 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168 1121451007827 heme-binding residues [chemical binding]; other site 1121451007828 Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281 1121451007829 homodimer interaction site [polypeptide binding]; other site 1121451007830 cofactor binding site; other site 1121451007831 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 1121451007832 phosphoglyceromutase; Provisional; Region: PRK05434 1121451007833 iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090 1121451007834 phenylacetate-CoA ligase; Region: PA_CoA_ligase; TIGR02155 1121451007835 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1121451007836 acyl-activating enzyme (AAE) consensus motif; other site 1121451007837 AMP binding site [chemical binding]; other site 1121451007838 active site 1121451007839 CoA binding site [chemical binding]; other site 1121451007840 ACT domain-containing protein [General function prediction only]; Region: COG4747 1121451007841 N-terminal ACT domain of a novel protein composed almost entirely of two tandem ACT domains; Region: ACT_Bt0572_1; cd04908 1121451007842 C-terminal ACT domain of a novel protein composed of just two ACT domains; Region: ACT_Bt0572_2; cd04882 1121451007843 Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139 1121451007844 hypothetical protein; Reviewed; Region: PRK09588 1121451007845 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1121451007846 putative binding surface; other site 1121451007847 active site 1121451007848 K+ potassium transporter; Region: K_trans; pfam02705 1121451007849 dihydrodipicolinate reductase; Provisional; Region: PRK00048 1121451007850 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 1121451007851 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 1121451007852 NAD-dependent DNA ligase (contains BRCT domain type II) [DNA replication, recombination, and repair]; Region: Lig; COG0272 1121451007853 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cl03295 1121451007854 nucleotide binding pocket [chemical binding]; other site 1121451007855 K-X-D-G motif; other site 1121451007856 catalytic site [active] 1121451007857 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 1121451007858 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 1121451007859 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 1121451007860 Dimer interface [polypeptide binding]; other site 1121451007861 BRCT sequence motif; other site 1121451007862 Ion channel; Region: Ion_trans_2; pfam07885 1121451007863 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 1121451007864 TrkA-N domain; Region: TrkA_N; pfam02254 1121451007865 TrkA-C domain; Region: TrkA_C; pfam02080 1121451007866 excinuclease ABC subunit B; Provisional; Region: PRK05298 1121451007867 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1121451007868 ATP binding site [chemical binding]; other site 1121451007869 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1121451007870 nucleotide binding region [chemical binding]; other site 1121451007871 ATP-binding site [chemical binding]; other site 1121451007872 Ultra-violet resistance protein B; Region: UvrB; pfam12344 1121451007873 leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301 1121451007874 Quinol:fumarate reductase (QFR) Type B subfamily, transmembrane subunit; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinone...; Region: QFR_TypeB_TM; cd00581 1121451007875 Iron-sulfur protein interface; other site 1121451007876 proximal heme binding site [chemical binding]; other site 1121451007877 distal heme binding site [chemical binding]; other site 1121451007878 dimer interface [polypeptide binding]; other site 1121451007879 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1121451007880 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1121451007881 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1121451007882 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1121451007883 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1121451007884 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1121451007885 M20 Peptidase T like enzymes specifically cleave tripeptides; Region: M20_peptT_like; cd05683 1121451007886 peptidase T-like protein; Region: PepT-like; TIGR01883 1121451007887 metal binding site [ion binding]; metal-binding site 1121451007888 putative dimer interface [polypeptide binding]; other site 1121451007889 A bacterial subgroup of the C-type lectin-like (CTLD) domain; a subgroup of bacterial protein domains homologous to the carbohydrate-recognition domains (CRDs) of the C-type lectins; Region: CLECT_VCBS; cd03603 1121451007890 ligand binding surface [chemical binding]; other site 1121451007891 HupF/HypC family; Region: HupF_HypC; pfam01455 1121451007892 coenzyme F420-reducing hydrogenase delta subunit (putative coenzyme F420 hydrogenase processing subunit); Region: frhD; TIGR00130 1121451007893 Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062 1121451007894 putative substrate-binding site; other site 1121451007895 nickel binding site [ion binding]; other site 1121451007896 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 1121451007897 Nickel-dependent hydrogenase; Region: NiFeSe_Hases; pfam00374 1121451007898 Ni,Fe-hydrogenase I small subunit [Energy production and conversion]; Region: HyaA; COG1740 1121451007899 Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409 1121451007900 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 1121451007901 thymidylate kinase; Validated; Region: tmk; PRK00698 1121451007902 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 1121451007903 TMP-binding site; other site 1121451007904 ATP-binding site [chemical binding]; other site 1121451007905 Predicted HD-superfamily hydrolase [General function prediction only]; Region: COG3481 1121451007906 YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492 1121451007907 generic binding surface I; other site 1121451007908 generic binding surface II; other site 1121451007909 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1121451007910 Zn2+ binding site [ion binding]; other site 1121451007911 Mg2+ binding site [ion binding]; other site 1121451007912 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 1121451007913 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 1121451007914 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 1121451007915 intersubunit interface [polypeptide binding]; other site 1121451007916 active site 1121451007917 zinc binding site [ion binding]; other site 1121451007918 Na+ binding site [ion binding]; other site 1121451007919 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 1121451007920 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 1121451007921 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1121451007922 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1121451007923 dimer interface [polypeptide binding]; other site 1121451007924 conserved gate region; other site 1121451007925 putative PBP binding loops; other site 1121451007926 ABC-ATPase subunit interface; other site 1121451007927 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1121451007928 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1121451007929 substrate binding pocket [chemical binding]; other site 1121451007930 membrane-bound complex binding site; other site 1121451007931 hinge residues; other site 1121451007932 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1121451007933 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1121451007934 dimer interface [polypeptide binding]; other site 1121451007935 conserved gate region; other site 1121451007936 ABC-ATPase subunit interface; other site 1121451007937 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 1121451007938 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1121451007939 Zn2+ binding site [ion binding]; other site 1121451007940 Mg2+ binding site [ion binding]; other site 1121451007941 HAMP domain; Region: HAMP; pfam00672 1121451007942 PAS fold; Region: PAS; pfam00989 1121451007943 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1121451007944 putative active site [active] 1121451007945 heme pocket [chemical binding]; other site 1121451007946 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1121451007947 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1121451007948 dimer interface [polypeptide binding]; other site 1121451007949 putative CheW interface [polypeptide binding]; other site 1121451007950 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: DUF374; Region: LPLAT_DUF374-like; cd07983 1121451007951 putative acyl-acceptor binding pocket; other site 1121451007952 lipid A export permease/ATP-binding protein MsbA; Region: MsbA_lipidA; TIGR02203 1121451007953 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1121451007954 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 1121451007955 Walker A/P-loop; other site 1121451007956 ATP binding site [chemical binding]; other site 1121451007957 Q-loop/lid; other site 1121451007958 ABC transporter signature motif; other site 1121451007959 Walker B; other site 1121451007960 D-loop; other site 1121451007961 H-loop/switch region; other site 1121451007962 SirA_like_N, a protein of unknown function with an N-terminal SirA-like domain. The SirA, YedF, YeeD protein family is present in bacteria as well as archaea. SirA (also known as UvrY, and YhhP) belongs to a family of a two-component response...; Region: SirA_like_N; cd03421 1121451007963 selenium metabolism protein YedF; Region: selenium_YedF; TIGR03527 1121451007964 CPxP motif; other site 1121451007965 DsrE/DsrF-like family; Region: DrsE; pfam02635 1121451007966 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1121451007967 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 1121451007968 RNA binding surface [nucleotide binding]; other site 1121451007969 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 1121451007970 active site 1121451007971 Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834 1121451007972 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl17548 1121451007973 L-2-amino-thiazoline-4-carboxylic acid hydrolase; Region: ATC_hydrolase; pfam14196 1121451007974 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 1121451007975 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1121451007976 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 1121451007977 elongation factor P; Validated; Region: PRK00529 1121451007978 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 1121451007979 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 1121451007980 RNA binding site [nucleotide binding]; other site 1121451007981 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 1121451007982 RNA binding site [nucleotide binding]; other site 1121451007983 Dehydroquinase class II; Region: DHquinase_II; pfam01220 1121451007984 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 1121451007985 trimer interface [polypeptide binding]; other site 1121451007986 active site 1121451007987 dimer interface [polypeptide binding]; other site 1121451007988 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 1121451007989 G1 box; other site 1121451007990 GTP/Mg2+ binding site [chemical binding]; other site 1121451007991 Switch I region; other site 1121451007992 G2 box; other site 1121451007993 G3 box; other site 1121451007994 Switch II region; other site 1121451007995 G4 box; other site 1121451007996 G5 box; other site 1121451007997 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 1121451007998 Predicted permeases [General function prediction only]; Region: COG0795 1121451007999 Predicted permeases [General function prediction only]; Region: COG0795 1121451008000 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 1121451008001 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 1121451008002 NMT1/THI5 like; Region: NMT1; pfam09084 1121451008003 PAS domain S-box; Region: sensory_box; TIGR00229 1121451008004 PAS domain; Region: PAS; smart00091 1121451008005 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1121451008006 dimer interface [polypeptide binding]; other site 1121451008007 phosphorylation site [posttranslational modification] 1121451008008 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1121451008009 ATP binding site [chemical binding]; other site 1121451008010 Mg2+ binding site [ion binding]; other site 1121451008011 G-X-G motif; other site 1121451008012 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1121451008013 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1121451008014 substrate binding pocket [chemical binding]; other site 1121451008015 membrane-bound complex binding site; other site 1121451008016 hinge residues; other site 1121451008017 Micrococcal nuclease (thermonuclease) homologs [DNA replication, recombination, and repair]; Region: COG1525 1121451008018 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 1121451008019 Domain of unknown function (DUF4198); Region: DUF4198; pfam10670 1121451008020 Response regulator receiver domain; Region: Response_reg; pfam00072 1121451008021 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121451008022 active site 1121451008023 phosphorylation site [posttranslational modification] 1121451008024 intermolecular recognition site; other site 1121451008025 Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437 1121451008026 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121451008027 active site 1121451008028 phosphorylation site [posttranslational modification] 1121451008029 intermolecular recognition site; other site 1121451008030 dimerization interface [polypeptide binding]; other site 1121451008031 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1121451008032 Zn2+ binding site [ion binding]; other site 1121451008033 Mg2+ binding site [ion binding]; other site 1121451008034 Helix-turn-helix domain; Region: HTH_28; pfam13518 1121451008035 Winged helix-turn helix; Region: HTH_29; pfam13551 1121451008036 Homeodomain-like domain; Region: HTH_32; pfam13565 1121451008037 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 1121451008038 Integrase core domain; Region: rve; pfam00665 1121451008039 Integrase core domain; Region: rve_3; pfam13683 1121451008040 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1121451008041 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1121451008042 Transposase; Region: HTH_Tnp_1; cl17663 1121451008043 Integrase core domain; Region: rve; pfam00665 1121451008044 Integrase core domain; Region: rve_3; pfam13683 1121451008045 Methylamine utilisation protein MauE; Region: MauE; pfam07291 1121451008046 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1121451008047 active site residue [active] 1121451008048 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 1121451008049 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1121451008050 putative substrate translocation pore; other site 1121451008051 Cupin domain; Region: Cupin_2; pfam07883 1121451008052 3,4-dihydroxy-2-butanone 4-phosphate synthase; Provisional; Region: ribB; PRK03353 1121451008053 3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108 1121451008054 argininosuccinate lyase; Provisional; Region: PRK00855 1121451008055 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 1121451008056 active sites [active] 1121451008057 tetramer interface [polypeptide binding]; other site 1121451008058 argininosuccinate synthase; Provisional; Region: PRK13820 1121451008059 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 1121451008060 ANP binding site [chemical binding]; other site 1121451008061 Substrate Binding Site II [chemical binding]; other site 1121451008062 Substrate Binding Site I [chemical binding]; other site 1121451008063 ornithine carbamoyltransferase; Provisional; Region: PRK00779 1121451008064 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1121451008065 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1121451008066 Uncharacterized protein family UPF0054; Region: UPF0054; pfam02130 1121451008067 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 1121451008068 PhoH-like protein; Region: PhoH; pfam02562 1121451008069 Response regulator receiver domain; Region: Response_reg; pfam00072 1121451008070 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121451008071 active site 1121451008072 phosphorylation site [posttranslational modification] 1121451008073 intermolecular recognition site; other site 1121451008074 dimerization interface [polypeptide binding]; other site 1121451008075 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 1121451008076 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 1121451008077 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1121451008078 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 1121451008079 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 1121451008080 Na binding site [ion binding]; other site 1121451008081 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 1121451008082 dimer interface [polypeptide binding]; other site 1121451008083 substrate binding site [chemical binding]; other site 1121451008084 phosphomethylpyrimidine kinase; Provisional; Region: PRK08573 1121451008085 ATP binding site [chemical binding]; other site 1121451008086 Putative aldolase; Region: Aldolase_2; pfam10120 1121451008087 uncharacterized radical SAM protein YgiQ; Region: SAM_YgiQ; TIGR03904 1121451008088 Radical SAM N-terminal; Region: Radical_SAM_N; pfam08497 1121451008089 Domain of unknown function (DUF3362); Region: DUF3362; pfam11842 1121451008090 Acetolactate synthase, small (regulatory) subunit [Amino acid transport and metabolism]; Region: IlvH; COG0440 1121451008091 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 1121451008092 putative valine binding site [chemical binding]; other site 1121451008093 dimer interface [polypeptide binding]; other site 1121451008094 acetolactate synthase catalytic subunit; Validated; Region: PRK08155 1121451008095 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1121451008096 PYR/PP interface [polypeptide binding]; other site 1121451008097 dimer interface [polypeptide binding]; other site 1121451008098 TPP binding site [chemical binding]; other site 1121451008099 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1121451008100 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 1121451008101 TPP-binding site [chemical binding]; other site 1121451008102 dimer interface [polypeptide binding]; other site 1121451008103 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1121451008104 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1121451008105 S-adenosylmethionine binding site [chemical binding]; other site 1121451008106 Predicted glycosyl transferase [General function prediction only]; Region: COG4671 1121451008107 Predicted glycosyl transferase [General function prediction only]; Region: COG4671 1121451008108 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1121451008109 This is a family of GT1 glycosyltransferases found specifically in certain bacteria. amsK in Erwinia amylovora, has been reported to be involved in the biosynthesis of amylovoran, a exopolysaccharide acting as a virulence factor; Region: GT1_amsK_like; cd03799 1121451008110 putative ADP-binding pocket [chemical binding]; other site 1121451008111 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1121451008112 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1121451008113 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1121451008114 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1121451008115 catalytic core [active] 1121451008116 Predicted glycosyl transferase [General function prediction only]; Region: COG4671 1121451008117 Glycosyltransferase family 28 C-terminal domain; Region: Glyco_tran_28_C; cl17369 1121451008118 Putative catalytic domain of uncharacterized bacterial proteins from the carbohydrate esterase 4 superfamily; Region: CE4_u4; cd10928 1121451008119 NodB motif; other site 1121451008120 putative active site [active] 1121451008121 putative catalytic site [active] 1121451008122 putative Zn binding site [ion binding]; other site 1121451008123 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 1121451008124 FtsX-like permease family; Region: FtsX; pfam02687 1121451008125 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1121451008126 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1121451008127 Walker A/P-loop; other site 1121451008128 ATP binding site [chemical binding]; other site 1121451008129 Q-loop/lid; other site 1121451008130 ABC transporter signature motif; other site 1121451008131 Walker B; other site 1121451008132 D-loop; other site 1121451008133 H-loop/switch region; other site 1121451008134 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 1121451008135 PA: Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain; Region: PA; cl08238 1121451008136 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 1121451008137 metal binding site [ion binding]; metal-binding site 1121451008138 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492 1121451008139 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1121451008140 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1121451008141 FtsX-like permease family; Region: FtsX; pfam02687 1121451008142 Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; cl05126 1121451008143 Domain of unknown function (DUF3391); Region: DUF3391; pfam11871 1121451008144 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 1121451008145 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1121451008146 Zn2+ binding site [ion binding]; other site 1121451008147 Mg2+ binding site [ion binding]; other site 1121451008148 Hpt domain; Region: Hpt; pfam01627 1121451008149 putative binding surface; other site 1121451008150 active site 1121451008151 Tim44-like domain; Region: Tim44; pfam04280 1121451008152 Response regulator receiver domain; Region: Response_reg; pfam00072 1121451008153 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121451008154 active site 1121451008155 phosphorylation site [posttranslational modification] 1121451008156 intermolecular recognition site; other site 1121451008157 dimerization interface [polypeptide binding]; other site 1121451008158 DMAP1-binding Domain; Region: DMAP_binding; pfam06464 1121451008159 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1121451008160 Zn2+ binding site [ion binding]; other site 1121451008161 Mg2+ binding site [ion binding]; other site 1121451008162 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 1121451008163 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 1121451008164 YfhG lipoprotein; Region: Lipoprotein_20; cl08141 1121451008165 HAD superfamily, subfamily IIIB (Acid phosphatase); Region: Acid_phosphat_B; cl17236 1121451008166 YibE/F-like protein; Region: YibE_F; pfam07907 1121451008167 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cl15837 1121451008168 Alkaline phosphatase homologues; Region: alkPPc; smart00098 1121451008169 active site 1121451008170 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cl15837 1121451008171 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168 1121451008172 heme-binding residues [chemical binding]; other site 1121451008173 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168 1121451008174 heme-binding residues [chemical binding]; other site 1121451008175 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168 1121451008176 heme-binding residues [chemical binding]; other site 1121451008177 Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512 1121451008178 4Fe-4S dicluster domain; Region: Fer4_17; pfam13534 1121451008179 NQR2, RnfD, RnfE family; Region: NQR2_RnfD_RnfE; pfam03116 1121451008180 FMN-binding domain; Region: FMN_bind; cl01081 1121451008181 electron transport complex RsxE subunit; Provisional; Region: PRK12405 1121451008182 Predicted NADH:ubiquinone oxidoreductase, subunit RnfA [Energy production and conversion]; Region: RnfA; COG4657 1121451008183 electron transport complex, RnfABCDGE type, B subunit; Region: rnfB; TIGR01944 1121451008184 putative glutamate synthase subunit beta; Provisional; Region: PRK12770 1121451008185 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1121451008186 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; pfam09723 1121451008187 Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009 1121451008188 Transglycosylase; Region: Transgly; pfam00912 1121451008189 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1121451008190 Glutamine phosphoribosylpyrophosphate amidotransferase [Nucleotide transport and metabolism]; Region: PurF; COG0034 1121451008191 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 1121451008192 active site 1121451008193 tetramer interface [polypeptide binding]; other site 1121451008194 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1121451008195 active site 1121451008196 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 1121451008197 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1121451008198 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1121451008199 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 1121451008200 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1121451008201 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1121451008202 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 1121451008203 IMP binding site; other site 1121451008204 dimer interface [polypeptide binding]; other site 1121451008205 interdomain contacts; other site 1121451008206 partial ornithine binding site; other site 1121451008207 FeoA domain; Region: FeoA; pfam04023 1121451008208 SlyX; Region: SlyX; pfam04102 1121451008209 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 1121451008210 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 1121451008211 active site 1121451008212 HIGH motif; other site 1121451008213 KMSKS motif; other site 1121451008214 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 1121451008215 anticodon binding site; other site 1121451008216 tRNA binding surface [nucleotide binding]; other site 1121451008217 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 1121451008218 dimer interface [polypeptide binding]; other site 1121451008219 putative tRNA-binding site [nucleotide binding]; other site 1121451008220 PSP1 C-terminal conserved region; Region: PSP1; cl00770 1121451008221 Response regulator receiver domain; Region: Response_reg; pfam00072 1121451008222 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121451008223 active site 1121451008224 phosphorylation site [posttranslational modification] 1121451008225 intermolecular recognition site; other site 1121451008226 dimerization interface [polypeptide binding]; other site 1121451008227 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 1121451008228 Competence protein; Region: Competence; pfam03772 1121451008229 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 1121451008230 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1121451008231 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 1121451008232 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 1121451008233 hinge; other site 1121451008234 active site 1121451008235 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 1121451008236 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 1121451008237 tetramer interface [polypeptide binding]; other site 1121451008238 heme binding pocket [chemical binding]; other site 1121451008239 NADPH binding site [chemical binding]; other site 1121451008240 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1121451008241 metal binding site 2 [ion binding]; metal-binding site 1121451008242 putative DNA binding helix; other site 1121451008243 metal binding site 1 [ion binding]; metal-binding site 1121451008244 dimer interface [polypeptide binding]; other site 1121451008245 structural Zn2+ binding site [ion binding]; other site 1121451008246 selenocysteine-specific elongation factor SelB; Region: selB; TIGR00475 1121451008247 SelB, the dedicated elongation factor for delivery of selenocysteinyl-tRNA to the ribosome; Region: SelB; cd04171 1121451008248 G1 box; other site 1121451008249 putative GEF interaction site [polypeptide binding]; other site 1121451008250 GTP/Mg2+ binding site [chemical binding]; other site 1121451008251 Switch I region; other site 1121451008252 G2 box; other site 1121451008253 G3 box; other site 1121451008254 Switch II region; other site 1121451008255 G4 box; other site 1121451008256 G5 box; other site 1121451008257 selB_II: this subfamily represents the domain of elongation factor SelB, homologous to domain II of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several...; Region: selB_II; cd03696 1121451008258 This family represents the domain of elongation factor SelB, homologous to domain III of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several elements:...; Region: selB_III; cd04094 1121451008259 Elongation factor SelB, winged helix; Region: SelB-wing_2; pfam09106 1121451008260 Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107 1121451008261 M18 Peptidase Aminopeptidase I; Region: M18_API; cd05659 1121451008262 Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127 1121451008263 oligomer interface [polypeptide binding]; other site 1121451008264 putative active site [active] 1121451008265 metal binding site [ion binding]; metal-binding site 1121451008266 selenocysteine synthase; Provisional; Region: PRK04311 1121451008267 Selenocysteine synthase N terminal; Region: Se-cys_synth_N; pfam12390 1121451008268 Selenocysteine synthase [seryl-tRNASer selenium transferase] [Amino acid transport and metabolism]; Region: SelA; COG1921 1121451008269 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1121451008270 catalytic residue [active] 1121451008271 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 1121451008272 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1121451008273 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1121451008274 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1121451008275 Conserved TM helix; Region: TM_helix; pfam05552 1121451008276 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1121451008277 Phophatidylserine decarboxylase; Region: PSDC; pfam12588 1121451008278 Phosphatidylserine decarboxylase; Region: PS_Dcarbxylase; pfam02666 1121451008279 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme 1121451008280 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme 1121451008281 Fe-S-cluster-containing hydrogenase components 2 [Energy production and conversion]; Region: HycB; COG1142 1121451008282 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 1121451008283 [FeFe] hydrogenase, group A; Region: FeFe_hydrog_A; TIGR02512 1121451008284 4Fe-4S binding domain; Region: Fer4; pfam00037 1121451008285 Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906 1121451008286 Iron hydrogenase small subunit; Region: Fe_hyd_SSU; pfam02256 1121451008287 Fe-S-cluster-containing hydrogenase components 2 [Energy production and conversion]; Region: HycB; COG1142 1121451008288 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 1121451008289 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 1121451008290 core domain interface [polypeptide binding]; other site 1121451008291 delta subunit interface [polypeptide binding]; other site 1121451008292 epsilon subunit interface [polypeptide binding]; other site 1121451008293 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 1121451008294 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1121451008295 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1121451008296 Walker A motif; other site 1121451008297 ATP binding site [chemical binding]; other site 1121451008298 Walker B motif; other site 1121451008299 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1121451008300 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 1121451008301 alternate F1F0 ATPase, F0 subunit B; Region: alt_F1F0_F0_B; TIGR03321 1121451008302 F0F1 ATP synthase subunit C; Provisional; Region: PRK13468 1121451008303 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 1121451008304 ATP synthase A chain; Region: ATP-synt_A; cl00413 1121451008305 N-ATPase, AtpR subunit; Region: AtpR; pfam12966 1121451008306 Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; cl09754 1121451008307 F0F1 ATP synthase subunit epsilon; Validated; Region: PRK06228 1121451008308 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 1121451008309 gamma subunit interface [polypeptide binding]; other site 1121451008310 epsilon subunit interface [polypeptide binding]; other site 1121451008311 LBP interface [polypeptide binding]; other site 1121451008312 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 1121451008313 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1121451008314 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 1121451008315 alpha subunit interaction interface [polypeptide binding]; other site 1121451008316 Walker A motif; other site 1121451008317 ATP binding site [chemical binding]; other site 1121451008318 Walker B motif; other site 1121451008319 inhibitor binding site; inhibition site 1121451008320 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1121451008321 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 1121451008322 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1121451008323 ATP binding site [chemical binding]; other site 1121451008324 putative Mg++ binding site [ion binding]; other site 1121451008325 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1121451008326 nucleotide binding region [chemical binding]; other site 1121451008327 ATP-binding site [chemical binding]; other site 1121451008328 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 1121451008329 HRDC domain; Region: HRDC; pfam00570 1121451008330 Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668 1121451008331 Predicted transcriptional regulator [Transcription]; Region: COG3905 1121451008332 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 1121451008333 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 1121451008334 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 1121451008335 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 1121451008336 Low molecular weight phosphatase family; Region: LMWPc; cd00115 1121451008337 active site 1121451008338 ABC transporter substrate binding protein; Region: ABC_sub_bind; cl17301 1121451008339 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1121451008340 Ligand Binding Site [chemical binding]; other site 1121451008341 GTPase RsgA; Reviewed; Region: PRK01889 1121451008342 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 1121451008343 GTPase/Zn-binding domain interface [polypeptide binding]; other site 1121451008344 GTP/Mg2+ binding site [chemical binding]; other site 1121451008345 G4 box; other site 1121451008346 G5 box; other site 1121451008347 G1 box; other site 1121451008348 Switch I region; other site 1121451008349 G2 box; other site 1121451008350 G3 box; other site 1121451008351 Switch II region; other site 1121451008352 Esterase-like activity of phytase; Region: Phytase-like; pfam13449 1121451008353 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1121451008354 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1121451008355 substrate binding pocket [chemical binding]; other site 1121451008356 membrane-bound complex binding site; other site 1121451008357 hinge residues; other site 1121451008358 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1121451008359 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1121451008360 putative active site [active] 1121451008361 heme pocket [chemical binding]; other site 1121451008362 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1121451008363 dimer interface [polypeptide binding]; other site 1121451008364 phosphorylation site [posttranslational modification] 1121451008365 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1121451008366 ATP binding site [chemical binding]; other site 1121451008367 Mg2+ binding site [ion binding]; other site 1121451008368 G-X-G motif; other site 1121451008369 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1121451008370 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1121451008371 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762 1121451008372 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1121451008373 Ligand Binding Site [chemical binding]; other site 1121451008374 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 1121451008375 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 1121451008376 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1121451008377 Catalytic site [active] 1121451008378 DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609 1121451008379 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 1121451008380 active site 1121451008381 DNA binding site [nucleotide binding] 1121451008382 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 1121451008383 TPR repeat; Region: TPR_11; pfam13414 1121451008384 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1121451008385 TPR motif; other site 1121451008386 TPR repeat; Region: TPR_11; pfam13414 1121451008387 binding surface 1121451008388 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 1121451008389 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1121451008390 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1121451008391 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1121451008392 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1121451008393 Acetyl-CoA carboxylase beta subunit [Lipid metabolism]; Region: AccD; COG0777 1121451008394 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1121451008395 N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; cl17549 1121451008396 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 1121451008397 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; Region: MATE_NorM_like; cd13137 1121451008398 Uncharacterized conserved protein (DUF2156); Region: DUF2156; cl12090 1121451008399 Uncharacterized conserved protein [Function unknown]; Region: COG3379 1121451008400 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 1121451008401 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 1121451008402 Part of AAA domain; Region: AAA_19; pfam13245 1121451008403 Family description; Region: UvrD_C_2; pfam13538 1121451008404 thiamine monophosphate kinase; Provisional; Region: PRK05731 1121451008405 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 1121451008406 ATP binding site [chemical binding]; other site 1121451008407 dimerization interface [polypeptide binding]; other site 1121451008408 Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281 1121451008409 homodimer interaction site [polypeptide binding]; other site 1121451008410 cofactor binding site; other site 1121451008411 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 1121451008412 rRNA binding site [nucleotide binding]; other site 1121451008413 predicted 30S ribosome binding site; other site 1121451008414 RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399 1121451008415 ketol-acid reductoisomerase; Provisional; Region: PRK05479 1121451008416 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 1121451008417 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 1121451008418 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 1121451008419 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 1121451008420 putative valine binding site [chemical binding]; other site 1121451008421 dimer interface [polypeptide binding]; other site 1121451008422 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 1121451008423 acetolactate synthase 3 catalytic subunit; Reviewed; Region: PRK06048 1121451008424 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1121451008425 PYR/PP interface [polypeptide binding]; other site 1121451008426 dimer interface [polypeptide binding]; other site 1121451008427 TPP binding site [chemical binding]; other site 1121451008428 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1121451008429 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 1121451008430 TPP-binding site [chemical binding]; other site 1121451008431 dimer interface [polypeptide binding]; other site 1121451008432 Uncharacterized ACR, YggU family COG1872; Region: DUF167; pfam02594 1121451008433 DivIVA protein; Region: DivIVA; pfam05103 1121451008434 DivIVA domain; Region: DivI1A_domain; TIGR03544 1121451008435 YGGT family; Region: YGGT; pfam02325 1121451008436 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 1121451008437 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1121451008438 active site 1121451008439 motif I; other site 1121451008440 motif II; other site 1121451008441 twin arginine translocase protein A; Provisional; Region: tatA; PRK14859 1121451008442 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 1121451008443 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 1121451008444 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 1121451008445 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 1121451008446 active site 1121451008447 (T/H)XGH motif; other site 1121451008448 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 1121451008449 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1121451008450 S-adenosylmethionine binding site [chemical binding]; other site 1121451008451 Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236 1121451008452 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1121451008453 Beta-Casp domain; Region: Beta-Casp; smart01027 1121451008454 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 1121451008455 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 1121451008456 EamA-like transporter family; Region: EamA; pfam00892 1121451008457 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1121451008458 molybdate ABC transporter periplasmic substrate-binding protein; Provisional; Region: PRK04168 1121451008459 tungstate ABC transporter binding protein WtpA; Region: tungstate_WtpA; TIGR03730 1121451008460 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1121451008461 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 1121451008462 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 1121451008463 Heparinase II/III-like protein; Region: Hepar_II_III; pfam07940 1121451008464 putative secretion ATPase, PEP-CTERM locus subfamily; Region: pepcterm_ATPase; TIGR03015 1121451008465 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1121451008466 Walker A motif; other site 1121451008467 ATP binding site [chemical binding]; other site 1121451008468 Walker B motif; other site 1121451008469 arginine finger; other site 1121451008470 exopolysaccharide/PEP-CTERM locus tyrosine autokinase; Region: pepcterm_TyrKin; TIGR03018 1121451008471 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1121451008472 polysaccharide chain length determinant protein, PEP-CTERM locus subfamily; Region: pepcterm_ChnLen; TIGR03007 1121451008473 Chain length determinant protein; Region: Wzz; cl15801 1121451008474 Actin cytoskeleton-regulatory complex protein END3; Region: End3; pfam12761 1121451008475 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 1121451008476 Chain length determinant protein; Region: Wzz; cl15801 1121451008477 uncharacterized protein, PEP-CTERM system associated; Region: pepcterm_hypo_1; TIGR03016 1121451008478 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 1121451008479 putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027 1121451008480 SLBB domain; Region: SLBB; pfam10531 1121451008481 Undecaprenyl-phosphate glucose phosphotransferase; Region: WcaJ_sugtrans; TIGR03023 1121451008482 Bacterial sugar transferase; Region: Bac_transf; pfam02397 1121451008483 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1121451008484 binding surface 1121451008485 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1121451008486 TPR motif; other site 1121451008487 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1121451008488 binding surface 1121451008489 TPR motif; other site 1121451008490 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1121451008491 binding surface 1121451008492 TPR motif; other site 1121451008493 TPR repeat; Region: TPR_11; pfam13414 1121451008494 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1121451008495 binding surface 1121451008496 TPR motif; other site 1121451008497 TPR repeat; Region: TPR_11; pfam13414 1121451008498 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1121451008499 TPR motif; other site 1121451008500 binding surface 1121451008501 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1121451008502 binding surface 1121451008503 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1121451008504 TPR motif; other site 1121451008505 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1121451008506 TPR motif; other site 1121451008507 binding surface 1121451008508 Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895 1121451008509 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1121451008510 binding surface 1121451008511 TPR motif; other site 1121451008512 exosortase D, VPLPA-CTERM-specific; Region: exosort_VPLPA; TIGR04152 1121451008513 Predicted membrane protein [Function unknown]; Region: COG4083; cl15694 1121451008514 Protein of unknown function (DUF3485); Region: DUF3485; pfam11984 1121451008515 Heparinase II/III-like protein; Region: Hepar_II_III; pfam07940 1121451008516 O-Antigen ligase; Region: Wzy_C; cl04850 1121451008517 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1121451008518 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1121451008519 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1121451008520 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the GGDEF (DiGuanylate-Cyclase (DGC)) domain. The GGDEF domain has been suggested to be homologous to the adenylyl cyclase catalytic domain and...; Region: CBS_pair_GGDEF_assoc; cd04598 1121451008521 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1121451008522 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1121451008523 metal binding site [ion binding]; metal-binding site 1121451008524 active site 1121451008525 I-site; other site 1121451008526 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 1121451008527 AAA domain; Region: AAA_30; pfam13604 1121451008528 Family description; Region: UvrD_C_2; pfam13538 1121451008529 recombination protein RecR; Reviewed; Region: recR; PRK00076 1121451008530 RecR protein; Region: RecR; pfam02132 1121451008531 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 1121451008532 active site 1121451008533 metal binding site [ion binding]; metal-binding site 1121451008534 hypothetical protein; Validated; Region: PRK00153 1121451008535 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14959 1121451008536 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1121451008537 Walker A motif; other site 1121451008538 ATP binding site [chemical binding]; other site 1121451008539 Walker B motif; other site 1121451008540 arginine finger; other site 1121451008541 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 1121451008542 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 1121451008543 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 1121451008544 homodimer interface [polypeptide binding]; other site 1121451008545 substrate-cofactor binding pocket; other site 1121451008546 catalytic residue [active] 1121451008547 N-terminal Early set domain associated with the catalytic domain of isoamylase-like (also called glycogen 6-glucanohydrolase) proteins; Region: E_set_Isoamylase_like_N; cd07184 1121451008548 aminotransferase; Validated; Region: PRK08175 1121451008549 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1121451008550 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1121451008551 homodimer interface [polypeptide binding]; other site 1121451008552 catalytic residue [active] 1121451008553 homoserine dehydrogenase; Provisional; Region: PRK06349 1121451008554 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 1121451008555 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 1121451008556 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 1121451008557 cofactor-independent phosphoglycerate mutase; Provisional; Region: PRK04200 1121451008558 2,3-bisphosphoglycerate-independent phosphoglycerate mutase; Region: PhosphMutase; cl17294 1121451008559 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1121451008560 active site 1121451008561 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1121451008562 Protein of unknown function (DUF2867); Region: DUF2867; pfam11066 1121451008563 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 1121451008564 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1121451008565 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1121451008566 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168 1121451008567 heme-binding residues [chemical binding]; other site 1121451008568 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 1121451008569 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1121451008570 Walker A/P-loop; other site 1121451008571 ATP binding site [chemical binding]; other site 1121451008572 Q-loop/lid; other site 1121451008573 ABC transporter signature motif; other site 1121451008574 Walker B; other site 1121451008575 D-loop; other site 1121451008576 H-loop/switch region; other site 1121451008577 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1121451008578 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1121451008579 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 1121451008580 TM-ABC transporter signature motif; other site 1121451008581 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1121451008582 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 1121451008583 TM-ABC transporter signature motif; other site 1121451008584 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 1121451008585 Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353 1121451008586 putative ligand binding site [chemical binding]; other site 1121451008587 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1121451008588 active site 1121451008589 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1121451008590 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1121451008591 metal binding site [ion binding]; metal-binding site 1121451008592 active site 1121451008593 I-site; other site 1121451008594 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 1121451008595 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1121451008596 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01096 1121451008597 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; smart00471 1121451008598 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 1121451008599 mercuric reductase; Validated; Region: PRK06370 1121451008600 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1121451008601 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1121451008602 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1121451008603 Glucokinase; Region: Glucokinase; cl17310 1121451008604 glucokinase, proteobacterial type; Region: glk; TIGR00749 1121451008605 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 1121451008606 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1121451008607 ligand binding site [chemical binding]; other site 1121451008608 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 1121451008609 Maf-like protein; Reviewed; Region: PRK00078 1121451008610 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 1121451008611 active site 1121451008612 dimer interface [polypeptide binding]; other site 1121451008613 Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878 1121451008614 PAS fold; Region: PAS_4; pfam08448 1121451008615 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1121451008616 PAS domain; Region: PAS_9; pfam13426 1121451008617 putative active site [active] 1121451008618 heme pocket [chemical binding]; other site 1121451008619 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1121451008620 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1121451008621 metal binding site [ion binding]; metal-binding site 1121451008622 active site 1121451008623 I-site; other site 1121451008624 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1121451008625 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 1121451008626 tetramer interfaces [polypeptide binding]; other site 1121451008627 binuclear metal-binding site [ion binding]; other site 1121451008628 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 1121451008629 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1121451008630 ligand binding site [chemical binding]; other site 1121451008631 tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800 1121451008632 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 1121451008633 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 1121451008634 TolA protein; Region: tolA_full; TIGR02794 1121451008635 TonB C terminal; Region: TonB_2; pfam13103 1121451008636 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 1121451008637 TolR protein; Region: tolR; TIGR02801 1121451008638 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 1121451008639 NAD-dependent deacetylase; Provisional; Region: PRK00481 1121451008640 SIR2 family of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2-fam; cd01407 1121451008641 NAD+ binding site [chemical binding]; other site 1121451008642 substrate binding site [chemical binding]; other site 1121451008643 Zn binding site [ion binding]; other site 1121451008644 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase; Region: PHP_HisPPase; cd07432 1121451008645 active site 1121451008646 hypothetical protein; Provisional; Region: PRK06361 1121451008647 Bifunctional nuclease; Region: DNase-RNase; pfam02577 1121451008648 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14337 1121451008649 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 1121451008650 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1121451008651 FeS/SAM binding site; other site 1121451008652 TRAM domain; Region: TRAM; cl01282 1121451008653 Ketosteroid isomerase homolog [Function unknown]; Region: COG4319 1121451008654 SnoaL-like domain; Region: SnoaL_3; pfam13474 1121451008655 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 1121451008656 Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125 1121451008657 active site 1121451008658 Phosphotransferase enzyme family; Region: APH; pfam01636 1121451008659 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1121451008660 Ribokinase-like subgroup A. Found in bacteria and archaea, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_A; cd01942 1121451008661 substrate binding site [chemical binding]; other site 1121451008662 ATP binding site [chemical binding]; other site 1121451008663 Uncharacterized protein involved in tolerance to divalent cations [Inorganic ion transport and metabolism]; Region: CutA; COG1324 1121451008664 Cytochrome c; Region: Cytochrom_C; cl11414 1121451008665 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 1121451008666 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1121451008667 minor groove reading motif; other site 1121451008668 helix-hairpin-helix signature motif; other site 1121451008669 substrate binding pocket [chemical binding]; other site 1121451008670 active site 1121451008671 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 1121451008672 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 1121451008673 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 1121451008674 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 1121451008675 putative active site [active] 1121451008676 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK11468 1121451008677 Dak1 domain; Region: Dak1; pfam02733 1121451008678 DAK2 domain; Region: Dak2; cl03685 1121451008679 dihydroxyacetone kinase subunit M; Provisional; Region: PRK11377 1121451008680 dihydroxyacetone kinase, phosphotransfer subunit; Region: dha_pts; TIGR02364 1121451008681 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 1121451008682 regulatory protein interface [polypeptide binding]; other site 1121451008683 active site 1121451008684 regulatory phosphorylation site [posttranslational modification]; other site 1121451008685 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 1121451008686 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 1121451008687 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1121451008688 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 1121451008689 Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412 1121451008690 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 1121451008691 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1121451008692 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 1121451008693 Iron-containing alcohol dehydrogenases-like; Region: Fe-ADH1; cd08185 1121451008694 putative active site [active] 1121451008695 metal binding site [ion binding]; metal-binding site 1121451008696 AMIN domain; Region: AMIN; pfam11741 1121451008697 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 1121451008698 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 1121451008699 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 1121451008700 active site 1121451008701 CoA binding domain; Region: CoA_binding_2; pfam13380 1121451008702 Flagellin N-methylase; Region: FliB; pfam03692 1121451008703 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1121451008704 HSP70 interaction site [polypeptide binding]; other site 1121451008705 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141 1121451008706 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 1121451008707 putative active site [active] 1121451008708 oxyanion strand; other site 1121451008709 catalytic triad [active] 1121451008710 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 1121451008711 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 1121451008712 substrate binding site [chemical binding]; other site 1121451008713 glutamase interaction surface [polypeptide binding]; other site 1121451008714 PPIC-type PPIASE domain; Region: Rotamase_2; cl08278 1121451008715 Virulence protein RhuM family; Region: Virulence_RhuM; pfam13310 1121451008716 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1121451008717 Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439 1121451008718 PAP2_like_4 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_4; cd03395 1121451008719 active site 1121451008720 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1121451008721 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 1121451008722 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 1121451008723 dimer interface [polypeptide binding]; other site 1121451008724 active site 1121451008725 glycine-pyridoxal phosphate binding site [chemical binding]; other site 1121451008726 folate binding site [chemical binding]; other site 1121451008727 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 1121451008728 chromosome replication initiation inhibitor protein; Validated; Region: PRK03635 1121451008729 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1121451008730 The C-terminal substrate binding domain of LysR-type transcriptional regulator, ArgP (IciA), for arginine exporter (ArgO); contains the type 2 periplasmic binding fold; Region: PBP2_IciA_ArgP; cd08428 1121451008731 putative dimerization interface [polypeptide binding]; other site 1121451008732 Lysine efflux permease [General function prediction only]; Region: COG1279 1121451008733 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 1121451008734 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1121451008735 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 1121451008736 Ligand binding site; other site 1121451008737 Putative Catalytic site; other site 1121451008738 DXD motif; other site 1121451008739 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1121451008740 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1121451008741 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1121451008742 Walker A motif; other site 1121451008743 ATP binding site [chemical binding]; other site 1121451008744 Walker B motif; other site 1121451008745 arginine finger; other site 1121451008746 Putative metallopeptidase domain; Region: DUF2201_N; pfam13203 1121451008747 VWA-like domain (DUF2201); Region: DUF2201; pfam09967 1121451008748 Predicted membrane protein [Function unknown]; Region: COG1971 1121451008749 Domain of unknown function DUF; Region: DUF204; pfam02659 1121451008750 Domain of unknown function DUF; Region: DUF204; pfam02659 1121451008751 Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG0429 1121451008752 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086 1121451008753 putative binding surface; other site 1121451008754 active site 1121451008755 Cache domain; Region: Cache_2; cl07034 1121451008756 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1121451008757 dimerization interface [polypeptide binding]; other site 1121451008758 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1121451008759 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1121451008760 dimer interface [polypeptide binding]; other site 1121451008761 putative CheW interface [polypeptide binding]; other site 1121451008762 Stress responsive A/B Barrel Domain; Region: Dabb; smart00886 1121451008763 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 1121451008764 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1121451008765 dimerization interface [polypeptide binding]; other site 1121451008766 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1121451008767 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1121451008768 dimer interface [polypeptide binding]; other site 1121451008769 putative CheW interface [polypeptide binding]; other site 1121451008770 Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139 1121451008771 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 1121451008772 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 1121451008773 Cysteine-rich domain; Region: CCG; pfam02754 1121451008774 Cysteine-rich domain; Region: CCG; pfam02754 1121451008775 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 1121451008776 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 1121451008777 propionate/acetate kinase; Provisional; Region: PRK12379 1121451008778 phosphate acetyltransferase; Reviewed; Region: PRK05632 1121451008779 Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132 1121451008780 DRTGG domain; Region: DRTGG; pfam07085 1121451008781 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 1121451008782 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1121451008783 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 1121451008784 Cysteine-rich domain; Region: CCG; pfam02754 1121451008785 Cysteine-rich domain; Region: CCG; pfam02754 1121451008786 FAD binding domain; Region: FAD_binding_4; pfam01565 1121451008787 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 1121451008788 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 1121451008789 L-lactate permease; Region: Lactate_perm; cl00701 1121451008790 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 1121451008791 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 1121451008792 dimer interface [polypeptide binding]; other site 1121451008793 PYR/PP interface [polypeptide binding]; other site 1121451008794 TPP binding site [chemical binding]; other site 1121451008795 substrate binding site [chemical binding]; other site 1121451008796 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 1121451008797 Domain of unknown function; Region: EKR; smart00890 1121451008798 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1121451008799 Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377 1121451008800 TPP-binding site [chemical binding]; other site 1121451008801 dimer interface [polypeptide binding]; other site 1121451008802 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 1121451008803 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121451008804 active site 1121451008805 phosphorylation site [posttranslational modification] 1121451008806 intermolecular recognition site; other site 1121451008807 dimerization interface [polypeptide binding]; other site 1121451008808 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1121451008809 Walker A motif; other site 1121451008810 ATP binding site [chemical binding]; other site 1121451008811 Walker B motif; other site 1121451008812 arginine finger; other site 1121451008813 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 1121451008814 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1121451008815 dimer interface [polypeptide binding]; other site 1121451008816 phosphorylation site [posttranslational modification] 1121451008817 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1121451008818 ATP binding site [chemical binding]; other site 1121451008819 Mg2+ binding site [ion binding]; other site 1121451008820 G-X-G motif; other site 1121451008821 Response regulator receiver domain; Region: Response_reg; pfam00072 1121451008822 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121451008823 active site 1121451008824 phosphorylation site [posttranslational modification] 1121451008825 intermolecular recognition site; other site 1121451008826 dimerization interface [polypeptide binding]; other site 1121451008827 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4246 1121451008828 Esterase-like activity of phytase; Region: Phytase-like; pfam13449 1121451008829 PAS fold; Region: PAS_4; pfam08448 1121451008830 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1121451008831 putative active site [active] 1121451008832 heme pocket [chemical binding]; other site 1121451008833 PAS domain S-box; Region: sensory_box; TIGR00229 1121451008834 PAS domain; Region: PAS_8; pfam13188 1121451008835 putative active site [active] 1121451008836 heme pocket [chemical binding]; other site 1121451008837 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 1121451008838 Histidine kinase; Region: HisKA_2; pfam07568 1121451008839 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1121451008840 ATP binding site [chemical binding]; other site 1121451008841 Mg2+ binding site [ion binding]; other site 1121451008842 G-X-G motif; other site 1121451008843 Protein of unknown function (DUF3568); Region: DUF3568; pfam12092 1121451008844 Response regulator receiver domain; Region: Response_reg; pfam00072 1121451008845 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121451008846 active site 1121451008847 phosphorylation site [posttranslational modification] 1121451008848 intermolecular recognition site; other site 1121451008849 dimerization interface [polypeptide binding]; other site 1121451008850 coenzyme A disulfide reductase; Reviewed; Region: PRK09564 1121451008851 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1121451008852 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1121451008853 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1121451008854 active site residue [active] 1121451008855 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 1121451008856 trimer interface [polypeptide binding]; other site 1121451008857 dimer interface [polypeptide binding]; other site 1121451008858 putative active site [active] 1121451008859 chaperone protein DnaJ; Provisional; Region: PRK14301 1121451008860 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1121451008861 HSP70 interaction site [polypeptide binding]; other site 1121451008862 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 1121451008863 substrate binding site [polypeptide binding]; other site 1121451008864 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 1121451008865 Zn binding sites [ion binding]; other site 1121451008866 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 1121451008867 dimer interface [polypeptide binding]; other site 1121451008868 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 1121451008869 Domain of unknown function (DUF4340); Region: DUF4340; pfam14238 1121451008870 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 1121451008871 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 1121451008872 Ligand Binding Site [chemical binding]; other site 1121451008873 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1121451008874 Peptidase family M23; Region: Peptidase_M23; pfam01551 1121451008875 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 1121451008876 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 1121451008877 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 1121451008878 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 1121451008879 FHIPEP family; Region: FHIPEP; pfam00771 1121451008880 flagellar biosynthetic protein FlhF; Region: FlhF; TIGR03499 1121451008881 SRP54-type protein, GTPase domain; Region: SRP54; smart00962 1121451008882 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 1121451008883 FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038 1121451008884 P-loop; other site 1121451008885 RNA polymerase sigma factor, FliA/WhiG family; Region: FliA_WhiG; TIGR02479 1121451008886 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1121451008887 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1121451008888 DNA binding residues [nucleotide binding] 1121451008889 chemotaxis regulatory protein CheY; Provisional; Region: PRK10610 1121451008890 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121451008891 active site 1121451008892 phosphorylation site [posttranslational modification] 1121451008893 intermolecular recognition site; other site 1121451008894 dimerization interface [polypeptide binding]; other site 1121451008895 Flagellar basal body-associated protein FliL; Region: FliL; pfam03748 1121451008896 K+-transporting ATPase, c chain; Region: KdpC; cl00944 1121451008897 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 1121451008898 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 1121451008899 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1121451008900 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1121451008901 dimer interface [polypeptide binding]; other site 1121451008902 putative CheW interface [polypeptide binding]; other site 1121451008903 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 1121451008904 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 1121451008905 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 1121451008906 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1121451008907 S-adenosylmethionine binding site [chemical binding]; other site 1121451008908 peptide chain release factor 1; Validated; Region: prfA; PRK00591 1121451008909 This domain is found in peptide chain release factors; Region: PCRF; smart00937 1121451008910 RF-1 domain; Region: RF-1; pfam00472 1121451008911 Protein of unknown function (DUF1385); Region: DUF1385; pfam07136 1121451008912 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 1121451008913 Dissimilatory sulfite reductase (desulfoviridin), gamma subunit [Inorganic ion transport and metabolism]; Region: DsrC; COG2920 1121451008914 DsrC like protein; Region: DsrC; pfam04358 1121451008915 putative methanogenesis marker protein 1; Region: methan_mark_1; TIGR03266 1121451008916 YcaO-like family; Region: YcaO; pfam02624 1121451008917 TPR repeat; Region: TPR_11; pfam13414 1121451008918 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1121451008919 TPR motif; other site 1121451008920 binding surface 1121451008921 TPR repeat; Region: TPR_11; pfam13414 1121451008922 RNA polymerase-binding protein DksA; Region: dksA; TIGR02420 1121451008923 Predicted RNA-binding protein homologous to eukaryotic snRNP [Transcription]; Region: COG1293 1121451008924 Domain of unknown function (DUF814); Region: DUF814; pfam05670 1121451008925 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1121451008926 TPR motif; other site 1121451008927 binding surface 1121451008928 TPR repeat; Region: TPR_11; pfam13414 1121451008929 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cl00399 1121451008930 MoaE homodimer interface [polypeptide binding]; other site 1121451008931 MoaD interaction [polypeptide binding]; other site 1121451008932 active site residues [active] 1121451008933 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1121451008934 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1121451008935 active site 1121451008936 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1121451008937 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1121451008938 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1121451008939 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1121451008940 S-adenosylmethionine binding site [chemical binding]; other site 1121451008941 Transglycosylase SLT domain; Region: SLT_2; pfam13406 1121451008942 murein hydrolase B; Provisional; Region: PRK10760; cl17906 1121451008943 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1121451008944 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1121451008945 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 1121451008946 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 1121451008947 MPT binding site; other site 1121451008948 trimer interface [polypeptide binding]; other site 1121451008949 Protein of unknown function (DUF1614); Region: DUF1614; pfam07758 1121451008950 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 1121451008951 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 1121451008952 substrate binding site; other site 1121451008953 tetramer interface; other site 1121451008954 PilZ domain; Region: PilZ; pfam07238 1121451008955 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 1121451008956 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_4; cd12162 1121451008957 putative ligand binding site [chemical binding]; other site 1121451008958 putative NAD binding site [chemical binding]; other site 1121451008959 catalytic site [active] 1121451008960 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1121451008961 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121451008962 active site 1121451008963 phosphorylation site [posttranslational modification] 1121451008964 intermolecular recognition site; other site 1121451008965 dimerization interface [polypeptide binding]; other site 1121451008966 Putative exonuclease, RdgC; Region: RdgC; cl01122 1121451008967 Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822 1121451008968 active site 1121451008969 catalytic triad [active] 1121451008970 oxyanion hole [active] 1121451008971 switch loop; other site 1121451008972 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 1121451008973 active site 1121451008974 nucleophile elbow; other site 1121451008975 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1121451008976 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1121451008977 putative efflux pump membrane fusion protein; Provisional; Region: PRK03598 1121451008978 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1121451008979 HlyD family secretion protein; Region: HlyD_3; pfam13437 1121451008980 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1121451008981 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1121451008982 Walker A/P-loop; other site 1121451008983 ATP binding site [chemical binding]; other site 1121451008984 Q-loop/lid; other site 1121451008985 ABC transporter signature motif; other site 1121451008986 Walker B; other site 1121451008987 D-loop; other site 1121451008988 H-loop/switch region; other site 1121451008989 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 1121451008990 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 1121451008991 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1121451008992 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1121451008993 Domain of unknown function (DUF4198); Region: DUF4198; pfam10670 1121451008994 MG2 domain; Region: A2M_N; pfam01835 1121451008995 hypothetical protein; Region: PHA00670 1121451008996 Bacteriophage head to tail connecting protein; Region: Head-tail_con; pfam12236 1121451008997 Phage-related terminase [General function prediction only]; Region: COG5362; cl02216 1121451008998 Protein of unknown function (DUF3154); Region: DUF3154; pfam11351 1121451008999 Uncharacterized conserved protein [Function unknown]; Region: COG0398 1121451009000 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1121451009001 YcaO-like family; Region: YcaO; pfam02624 1121451009002 Fic family protein [Function unknown]; Region: COG3177 1121451009003 Fic/DOC family; Region: Fic; pfam02661 1121451009004 hypothetical protein; Provisional; Region: PRK09936 1121451009005 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1121451009006 binding surface 1121451009007 TPR motif; other site 1121451009008 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 1121451009009 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1121451009010 binding surface 1121451009011 TPR motif; other site 1121451009012 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1121451009013 binding surface 1121451009014 TPR motif; other site 1121451009015 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1121451009016 binding surface 1121451009017 TPR motif; other site 1121451009018 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1121451009019 binding surface 1121451009020 TPR motif; other site 1121451009021 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1121451009022 binding surface 1121451009023 TPR motif; other site 1121451009024 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1121451009025 binding surface 1121451009026 TPR motif; other site 1121451009027 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1121451009028 binding surface 1121451009029 TPR motif; other site 1121451009030 Bacteriophage N adsorption protein A C-term; Region: NfrA_C; pfam13283 1121451009031 bacteriophage N4 adsorption protein B; Provisional; Region: nfrB; PRK11234 1121451009032 active site 1121451009033 Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632 1121451009034 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 1121451009035 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 1121451009036 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 1121451009037 active site 1121451009038 homodimer interface [polypeptide binding]; other site 1121451009039 PAS domain S-box; Region: sensory_box; TIGR00229 1121451009040 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1121451009041 putative active site [active] 1121451009042 heme pocket [chemical binding]; other site 1121451009043 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1121451009044 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1121451009045 dimer interface [polypeptide binding]; other site 1121451009046 phosphorylation site [posttranslational modification] 1121451009047 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1121451009048 ATP binding site [chemical binding]; other site 1121451009049 Mg2+ binding site [ion binding]; other site 1121451009050 G-X-G motif; other site 1121451009051 Iron-containing alcohol dehydrogenases-like; Region: Fe-ADH4; cd08188 1121451009052 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 1121451009053 putative active site [active] 1121451009054 metal binding site [ion binding]; metal-binding site 1121451009055 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 1121451009056 Cache domain; Region: Cache_1; pfam02743 1121451009057 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1121451009058 dimerization interface [polypeptide binding]; other site 1121451009059 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1121451009060 PAS domain; Region: PAS_9; pfam13426 1121451009061 putative active site [active] 1121451009062 heme pocket [chemical binding]; other site 1121451009063 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1121451009064 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1121451009065 metal binding site [ion binding]; metal-binding site 1121451009066 active site 1121451009067 I-site; other site 1121451009068 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1121451009069 [FeFe] hydrogenase H-cluster maturation GTPase HydF; Region: GTP_HydF; TIGR03918 1121451009070 E. coli Ras-like protein (Era)-like GTPase; Region: Era_like; cd00880 1121451009071 G1 box; other site 1121451009072 GTP/Mg2+ binding site [chemical binding]; other site 1121451009073 Switch I region; other site 1121451009074 G2 box; other site 1121451009075 Switch II region; other site 1121451009076 G3 box; other site 1121451009077 G4 box; other site 1121451009078 G5 box; other site 1121451009079 biotin synthase; Provisional; Region: PRK07094 1121451009080 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1121451009081 FeS/SAM binding site; other site 1121451009082 Biotin and Thiamin Synthesis associated domain; Region: BATS; cl06149 1121451009083 thiamine biosynthesis protein ThiH; Reviewed; Region: thiH; PRK09613 1121451009084 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1121451009085 FeS/SAM binding site; other site 1121451009086 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 1121451009087 putative iron-only hydrogenase system regulator; Region: hyd_TM1266; TIGR03959 1121451009088 Iron hydrogenase small subunit; Region: Fe_hyd_SSU; smart00902 1121451009089 4Fe-4S binding domain; Region: Fer4_6; pfam12837 1121451009090 Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906 1121451009091 Domain of unknown function (DUF4301); Region: DUF4301; pfam14134 1121451009092 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958 1121451009093 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 1121451009094 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 1121451009095 homodimer interface [polypeptide binding]; other site 1121451009096 substrate-cofactor binding pocket; other site 1121451009097 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1121451009098 catalytic residue [active] 1121451009099 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 1121451009100 L-Ala-D/L-Glu epimerase; Provisional; Region: PRK15129 1121451009101 active site 1121451009102 Protein of unknown function (DUF1611); Region: DUF1611; pfam07755 1121451009103 FeoA domain; Region: FeoA; pfam04023 1121451009104 ferrous iron transport protein B; Reviewed; Region: feoB; PRK09554 1121451009105 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 1121451009106 G1 box; other site 1121451009107 GTP/Mg2+ binding site [chemical binding]; other site 1121451009108 Switch I region; other site 1121451009109 G2 box; other site 1121451009110 G3 box; other site 1121451009111 Switch II region; other site 1121451009112 G4 box; other site 1121451009113 G5 box; other site 1121451009114 Nucleoside recognition; Region: Gate; pfam07670 1121451009115 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 1121451009116 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 1121451009117 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1121451009118 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 1121451009119 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1121451009120 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12668 1121451009121 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1121451009122 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK08375 1121451009123 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1121451009124 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492 1121451009125 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 1121451009126 NADH-quinone oxidoreductase, chain I; Region: NuoI; TIGR01971 1121451009127 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 1121451009128 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 1121451009129 NADH dehydrogenase subunit D; Validated; Region: PRK06075 1121451009130 NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649 1121451009131 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; pfam00329 1121451009132 NADH dehydrogenase subunit B; Validated; Region: PRK06411 1121451009133 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535 1121451009134 response regulator PleD; Reviewed; Region: pleD; PRK09581 1121451009135 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121451009136 active site 1121451009137 phosphorylation site [posttranslational modification] 1121451009138 intermolecular recognition site; other site 1121451009139 dimerization interface [polypeptide binding]; other site 1121451009140 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1121451009141 putative active site [active] 1121451009142 heme pocket [chemical binding]; other site 1121451009143 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1121451009144 metal binding site [ion binding]; metal-binding site 1121451009145 active site 1121451009146 I-site; other site 1121451009147 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1121451009148 UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs; Region: UGD_SDR_e; cd05230 1121451009149 NAD binding site [chemical binding]; other site 1121451009150 putative substrate binding site 2 [chemical binding]; other site 1121451009151 putative substrate binding site 1 [chemical binding]; other site 1121451009152 active site 1121451009153 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1121451009154 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1121451009155 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1121451009156 Coenzyme A binding pocket [chemical binding]; other site 1121451009157 OsmC-like protein; Region: OsmC; pfam02566 1121451009158 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 1121451009159 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 1121451009160 Bacterial Ig-like domain (group 1); Region: Big_1; cl17740 1121451009161 Transglutaminase-like superfamily; Region: Transglut_core; cl17362 1121451009162 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1121451009163 PAS domain; Region: PAS_9; pfam13426 1121451009164 putative active site [active] 1121451009165 heme pocket [chemical binding]; other site 1121451009166 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1121451009167 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1121451009168 PAS domain S-box; Region: sensory_box; TIGR00229 1121451009169 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1121451009170 putative active site [active] 1121451009171 heme pocket [chemical binding]; other site 1121451009172 PAS domain S-box; Region: sensory_box; TIGR00229 1121451009173 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1121451009174 putative active site [active] 1121451009175 heme pocket [chemical binding]; other site 1121451009176 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1121451009177 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1121451009178 metal binding site [ion binding]; metal-binding site 1121451009179 active site 1121451009180 I-site; other site 1121451009181 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1121451009182 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 1121451009183 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 1121451009184 putative valine binding site [chemical binding]; other site 1121451009185 dimer interface [polypeptide binding]; other site 1121451009186 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 1121451009187 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl17212 1121451009188 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1121451009189 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1121451009190 substrate binding pocket [chemical binding]; other site 1121451009191 membrane-bound complex binding site; other site 1121451009192 hinge residues; other site 1121451009193 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1121451009194 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1121451009195 substrate binding pocket [chemical binding]; other site 1121451009196 membrane-bound complex binding site; other site 1121451009197 hinge residues; other site 1121451009198 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964 1121451009199 YheO-like PAS domain; Region: PAS_6; pfam08348 1121451009200 HTH domain; Region: HTH_22; pfam13309 1121451009201 leucine transcriptional activator; Reviewed; Region: leuO; PRK09508 1121451009202 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1121451009203 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 1121451009204 substrate binding pocket [chemical binding]; other site 1121451009205 dimerization interface [polypeptide binding]; other site 1121451009206 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1121451009207 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1121451009208 dimer interface [polypeptide binding]; other site 1121451009209 putative CheW interface [polypeptide binding]; other site 1121451009210 Hemerythrin; Region: Hemerythrin; cd12107 1121451009211 Fe binding site [ion binding]; other site 1121451009212 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1121451009213 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1121451009214 DNA-binding site [nucleotide binding]; DNA binding site 1121451009215 FCD domain; Region: FCD; pfam07729 1121451009216 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1121451009217 Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809 1121451009218 active site 1121451009219 substrate binding site [chemical binding]; other site 1121451009220 FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070 1121451009221 FMN binding site [chemical binding]; other site 1121451009222 putative catalytic residues [active] 1121451009223 DNA polymerase III, delta subunit; Region: DNA_pol3_delta2; pfam13177 1121451009224 DNA polymerase III subunit delta'; Validated; Region: PRK08485 1121451009225 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 1121451009226 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 1121451009227 GDP-binding site [chemical binding]; other site 1121451009228 ACT binding site; other site 1121451009229 IMP binding site; other site 1121451009230 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1121451009231 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1121451009232 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1121451009233 catalytic residue [active] 1121451009234 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 1121451009235 RNB domain; Region: RNB; pfam00773 1121451009236 Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; cl00410 1121451009237 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1121451009238 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121451009239 active site 1121451009240 phosphorylation site [posttranslational modification] 1121451009241 intermolecular recognition site; other site 1121451009242 Domain of unknown function (DUF3369); Region: DUF3369; pfam11849 1121451009243 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1121451009244 Zn2+ binding site [ion binding]; other site 1121451009245 Mg2+ binding site [ion binding]; other site 1121451009246 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1121451009247 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121451009248 active site 1121451009249 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1121451009250 phosphorylation site [posttranslational modification] 1121451009251 intermolecular recognition site; other site 1121451009252 Domain of unknown function (DUF3369); Region: DUF3369; pfam11849 1121451009253 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1121451009254 dimer interface [polypeptide binding]; other site 1121451009255 phosphorylation site [posttranslational modification] 1121451009256 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1121451009257 ATP binding site [chemical binding]; other site 1121451009258 Mg2+ binding site [ion binding]; other site 1121451009259 G-X-G motif; other site 1121451009260 FOG: CBS domain [General function prediction only]; Region: COG0517 1121451009261 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the acetoin utilization proteins in bacteria. Acetoin is a product of fermentative metabolism in many prokaryotic and eukaryotic microorganisms. They produce...; Region: CBS_pair_ACT_assoc; cd04584 1121451009262 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 1121451009263 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1121451009264 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 1121451009265 S-adenosylmethionine binding site [chemical binding]; other site 1121451009266 2-keto-3-deoxy-galactonokinase [Carbohydrate transport and metabolism]; Region: DgoK; COG3734 1121451009267 8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958 1121451009268 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 1121451009269 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1121451009270 catalytic residue [active] 1121451009271 SPRY domain; Region: SPRY; cl02614 1121451009272 hypothetical protein; Region: PHA01733 1121451009273 hypothetical protein; Region: PHA00661 1121451009274 hypothetical protein; Region: PHA00662 1121451009275 hypothetical protein; Region: PHA00664 1121451009276 major capsid protein; Region: PHA00665 1121451009277 putative protease; Region: PHA00666 1121451009278 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 1121451009279 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 1121451009280 thiamine biosynthesis protein ThiC; Provisional; Region: PRK13352 1121451009281 thiamine biosynthesis protein ThiC; Region: thiC; TIGR00190 1121451009282 Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757 1121451009283 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR_like; cd08242 1121451009284 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1121451009285 putative NAD(P) binding site [chemical binding]; other site 1121451009286 catalytic Zn binding site [ion binding]; other site 1121451009287 structural Zn binding site [ion binding]; other site 1121451009288 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1121451009289 Uncharacterized ArCR, COG2043; Region: DUF169; pfam02596 1121451009290 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1121451009291 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 1121451009292 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1121451009293 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1121451009294 putative active site [active] 1121451009295 heme pocket [chemical binding]; other site 1121451009296 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1121451009297 dimer interface [polypeptide binding]; other site 1121451009298 phosphorylation site [posttranslational modification] 1121451009299 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1121451009300 ATP binding site [chemical binding]; other site 1121451009301 Mg2+ binding site [ion binding]; other site 1121451009302 G-X-G motif; other site 1121451009303 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 1121451009304 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 1121451009305 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1121451009306 binding surface 1121451009307 TPR motif; other site 1121451009308 Stage II sporulation protein; Region: SpoIID; pfam08486 1121451009309 SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669 1121451009310 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1121451009311 Interdomain contacts; other site 1121451009312 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 1121451009313 LPP20 lipoprotein; Region: LPP20; cl15824 1121451009314 TPR repeat; Region: TPR_11; pfam13414 1121451009315 S-layer homology domain; Region: SLH; pfam00395 1121451009316 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 1121451009317 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 1121451009318 sodium/proton antiporter; Reviewed; Region: nhaB; PRK09547 1121451009319 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 1121451009320 acetyl coenzyme A synthetase (ADP forming), alpha domain; Region: AcCoA-syn-alpha; TIGR02717 1121451009321 CoA binding domain; Region: CoA_binding_2; pfam13380 1121451009322 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 1121451009323 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1121451009324 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1121451009325 putative active site [active] 1121451009326 heme pocket [chemical binding]; other site 1121451009327 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1121451009328 putative active site [active] 1121451009329 heme pocket [chemical binding]; other site 1121451009330 PAS domain; Region: PAS; smart00091 1121451009331 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 1121451009332 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1121451009333 dimer interface [polypeptide binding]; other site 1121451009334 phosphorylation site [posttranslational modification] 1121451009335 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1121451009336 ATP binding site [chemical binding]; other site 1121451009337 Mg2+ binding site [ion binding]; other site 1121451009338 G-X-G motif; other site 1121451009339 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1121451009340 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1121451009341 WHG domain; Region: WHG; pfam13305 1121451009342 squalene-hopene cyclase; Region: hopene_cyclase; TIGR01507 1121451009343 Squalene cyclase (SQCY) domain subgroup 1; found in class II terpene cyclases that have an alpha 6 - alpha 6 barrel fold. Squalene cyclase (SQCY) and 2,3-oxidosqualene cyclase (OSQCY) are integral membrane proteins that catalyze a cationic cyclization...; Region: SQCY_1; cd02892 1121451009344 Active site cavity [active] 1121451009345 catalytic acid [active] 1121451009346 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1121451009347 Acyl-ACP thioesterase [Lipid metabolism]; Region: FatA; COG3884 1121451009348 active site 2 [active] 1121451009349 active site 1 [active] 1121451009350 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1121451009351 active site 1 [active] 1121451009352 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 1121451009353 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 1121451009354 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 1121451009355 active site 1121451009356 dimer interface [polypeptide binding]; other site 1121451009357 motif 1; other site 1121451009358 motif 2; other site 1121451009359 motif 3; other site 1121451009360 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 1121451009361 anticodon binding site; other site 1121451009362 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 1121451009363 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 1121451009364 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 1121451009365 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 1121451009366 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 1121451009367 23S rRNA binding site [nucleotide binding]; other site 1121451009368 L21 binding site [polypeptide binding]; other site 1121451009369 L13 binding site [polypeptide binding]; other site 1121451009370 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 1121451009371 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 1121451009372 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 1121451009373 dimer interface [polypeptide binding]; other site 1121451009374 motif 1; other site 1121451009375 active site 1121451009376 motif 2; other site 1121451009377 motif 3; other site 1121451009378 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 1121451009379 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 1121451009380 putative tRNA-binding site [nucleotide binding]; other site 1121451009381 B3/4 domain; Region: B3_4; pfam03483 1121451009382 tRNA synthetase B5 domain; Region: B5; smart00874 1121451009383 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 1121451009384 dimer interface [polypeptide binding]; other site 1121451009385 motif 1; other site 1121451009386 motif 3; other site 1121451009387 motif 2; other site 1121451009388 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 1121451009389 DNA-binding transcriptional repressor AcrR; Provisional; Region: PRK10668 1121451009390 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1121451009391 MAATS-type transcriptional repressor, C-terminal region; Region: TetR_C_2; pfam08361 1121451009392 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 1121451009393 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 1121451009394 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 1121451009395 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 1121451009396 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1121451009397 binding surface 1121451009398 TPR motif; other site 1121451009399 TPR repeat; Region: TPR_11; pfam13414 1121451009400 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1121451009401 binding surface 1121451009402 TPR motif; other site 1121451009403 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1121451009404 multidrug efflux protein; Reviewed; Region: PRK09579 1121451009405 phosphoglucomutase; Validated; Region: PRK07564 1121451009406 This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801 1121451009407 active site 1121451009408 substrate binding site [chemical binding]; other site 1121451009409 metal binding site [ion binding]; metal-binding site 1121451009410 Response regulator receiver domain; Region: Response_reg; pfam00072 1121451009411 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121451009412 active site 1121451009413 phosphorylation site [posttranslational modification] 1121451009414 intermolecular recognition site; other site 1121451009415 dimerization interface [polypeptide binding]; other site 1121451009416 PAS domain; Region: PAS; smart00091 1121451009417 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 1121451009418 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1121451009419 dimer interface [polypeptide binding]; other site 1121451009420 phosphorylation site [posttranslational modification] 1121451009421 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1121451009422 ATP binding site [chemical binding]; other site 1121451009423 Mg2+ binding site [ion binding]; other site 1121451009424 G-X-G motif; other site 1121451009425 Response regulator receiver domain; Region: Response_reg; pfam00072 1121451009426 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121451009427 active site 1121451009428 phosphorylation site [posttranslational modification] 1121451009429 intermolecular recognition site; other site 1121451009430 dimerization interface [polypeptide binding]; other site 1121451009431 Hpt domain; Region: Hpt; pfam01627 1121451009432 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 1121451009433 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121451009434 active site 1121451009435 phosphorylation site [posttranslational modification] 1121451009436 intermolecular recognition site; other site 1121451009437 dimerization interface [polypeptide binding]; other site 1121451009438 CheB methylesterase; Region: CheB_methylest; pfam01339 1121451009439 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1121451009440 putative binding surface; other site 1121451009441 active site 1121451009442 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1121451009443 ATP binding site [chemical binding]; other site 1121451009444 Mg2+ binding site [ion binding]; other site 1121451009445 G-X-G motif; other site 1121451009446 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 1121451009447 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121451009448 Response regulator receiver domain; Region: Response_reg; pfam00072 1121451009449 active site 1121451009450 phosphorylation site [posttranslational modification] 1121451009451 intermolecular recognition site; other site 1121451009452 dimerization interface [polypeptide binding]; other site 1121451009453 CheW-like domain; Region: CheW; pfam01584 1121451009454 Methyltransferase, chemotaxis proteins; Region: MeTrc; smart00138 1121451009455 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 1121451009456 TPR repeat; Region: TPR_11; pfam13414 1121451009457 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1121451009458 binding surface 1121451009459 TPR motif; other site 1121451009460 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1121451009461 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 1121451009462 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 1121451009463 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1121451009464 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1121451009465 catalytic residue [active] 1121451009466 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1121451009467 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1121451009468 metal binding site [ion binding]; metal-binding site 1121451009469 active site 1121451009470 I-site; other site 1121451009471 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 1121451009472 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1121451009473 TPR motif; other site 1121451009474 binding surface 1121451009475 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1121451009476 binding surface 1121451009477 TPR motif; other site 1121451009478 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1121451009479 TPR motif; other site 1121451009480 binding surface 1121451009481 pantoate--beta-alanine ligase; Region: panC; TIGR00018 1121451009482 Pantoate-beta-alanine ligase; Region: PanC; cd00560 1121451009483 active site 1121451009484 ATP-binding site [chemical binding]; other site 1121451009485 pantoate-binding site; other site 1121451009486 HXXH motif; other site 1121451009487 S-adenosylmethionine synthetase; Validated; Region: PRK05250 1121451009488 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 1121451009489 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 1121451009490 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 1121451009491 Short C-terminal domain; Region: SHOCT; pfam09851 1121451009492 spore photoproduct lyase; Region: photo_TT_lyase; cl15393 1121451009493 Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170 1121451009494 elongation factor G; Reviewed; Region: PRK12740 1121451009495 G1 box; other site 1121451009496 putative GEF interaction site [polypeptide binding]; other site 1121451009497 GTP/Mg2+ binding site [chemical binding]; other site 1121451009498 Switch I region; other site 1121451009499 G2 box; other site 1121451009500 G3 box; other site 1121451009501 Switch II region; other site 1121451009502 G4 box; other site 1121451009503 G5 box; other site 1121451009504 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 1121451009505 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 1121451009506 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 1121451009507 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1121451009508 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1121451009509 putative acyl-acceptor binding pocket; other site 1121451009510 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 1121451009511 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1121451009512 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 1121451009513 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 1121451009514 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1121451009515 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 1121451009516 rRNA interaction site [nucleotide binding]; other site 1121451009517 S8 interaction site; other site 1121451009518 putative laminin-1 binding site; other site 1121451009519 elongation factor Ts; Reviewed; Region: tsf; PRK12332 1121451009520 UBA/TS-N domain; Region: UBA; pfam00627 1121451009521 Elongation factor TS; Region: EF_TS; pfam00889 1121451009522 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 1121451009523 putative nucleotide binding site [chemical binding]; other site 1121451009524 uridine monophosphate binding site [chemical binding]; other site 1121451009525 homohexameric interface [polypeptide binding]; other site 1121451009526 ribosome recycling factor; Reviewed; Region: frr; PRK00083 1121451009527 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 1121451009528 hinge region; other site 1121451009529 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 1121451009530 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 1121451009531 catalytic residue [active] 1121451009532 putative FPP diphosphate binding site; other site 1121451009533 putative FPP binding hydrophobic cleft; other site 1121451009534 dimer interface [polypeptide binding]; other site 1121451009535 putative IPP diphosphate binding site; other site 1121451009536 Bacterial SH3 domain; Region: SH3_3; pfam08239 1121451009537 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1121451009538 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1121451009539 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1121451009540 Zn2+ binding site [ion binding]; other site 1121451009541 Mg2+ binding site [ion binding]; other site 1121451009542 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1121451009543 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 1121451009544 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 1121451009545 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 1121451009546 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 1121451009547 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 1121451009548 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 1121451009549 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 1121451009550 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 1121451009551 active site 1121451009552 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 1121451009553 protein binding site [polypeptide binding]; other site 1121451009554 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 1121451009555 putative substrate binding region [chemical binding]; other site 1121451009556 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 1121451009557 flagellin; Provisional; Region: PRK12804 1121451009558 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 1121451009559 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 1121451009560 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 1121451009561 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 1121451009562 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 1121451009563 Flagellin-specific chaperone FliS [Cell motility and secretion / Intracellular trafficking and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FliS; COG1516 1121451009564 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1121451009565 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1121451009566 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1121451009567 active site 1121451009568 zinc-ribbon domain; Region: zinc_ribbon_4; pfam13717 1121451009569 Uncharacterized protein conserved in archaea [Function unknown]; Region: COG2881 1121451009570 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 1121451009571 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1121451009572 ligand binding site [chemical binding]; other site 1121451009573 putative heme d1 biosynthesis radical SAM protein NirJ1; Region: rSAM_NirJ1; TIGR04054 1121451009574 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1121451009575 FeS/SAM binding site; other site 1121451009576 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 1121451009577 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 1121451009578 dimer interface [polypeptide binding]; other site 1121451009579 active site 1121451009580 Schiff base residues; other site 1121451009581 putative heme d1 biosynthesis radical SAM protein NirJ2; Region: rSAM_NirJ2; TIGR04055 1121451009582 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1121451009583 FeS/SAM binding site; other site 1121451009584 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 1121451009585 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 1121451009586 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 1121451009587 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 1121451009588 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 1121451009589 substrate binding site [chemical binding]; other site 1121451009590 hexamer interface [polypeptide binding]; other site 1121451009591 metal binding site [ion binding]; metal-binding site 1121451009592 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399 1121451009593 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1121451009594 PAS domain; Region: PAS_9; pfam13426 1121451009595 putative active site [active] 1121451009596 heme pocket [chemical binding]; other site 1121451009597 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1121451009598 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1121451009599 metal binding site [ion binding]; metal-binding site 1121451009600 active site 1121451009601 I-site; other site 1121451009602 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3009 1121451009603 Protein of unknown function (DUF330); Region: DUF330; cl01135 1121451009604 mce related protein; Region: MCE; pfam02470 1121451009605 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 1121451009606 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 1121451009607 Walker A/P-loop; other site 1121451009608 ATP binding site [chemical binding]; other site 1121451009609 Q-loop/lid; other site 1121451009610 ABC transporter signature motif; other site 1121451009611 Walker B; other site 1121451009612 D-loop; other site 1121451009613 H-loop/switch region; other site 1121451009614 STAS domain; Region: STAS_2; pfam13466 1121451009615 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 1121451009616 Permease; Region: Permease; pfam02405 1121451009617 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1121451009618 dimer interface [polypeptide binding]; other site 1121451009619 putative CheW interface [polypeptide binding]; other site 1121451009620 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1121451009621 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1121451009622 dimer interface [polypeptide binding]; other site 1121451009623 putative CheW interface [polypeptide binding]; other site 1121451009624 Proline dehydrogenase; Region: Pro_dh; cl03282 1121451009625 1-pyrroline-5-carboxylate dehydrogenase; Provisional; Region: PRK03137 1121451009626 Delta(1)-pyrroline-5-carboxylate dehydrogenase, RocA; Region: ALDH_PutA-P5CDH-RocA; cd07124 1121451009627 Glutamate binding site [chemical binding]; other site 1121451009628 homodimer interface [polypeptide binding]; other site 1121451009629 NAD binding site [chemical binding]; other site 1121451009630 catalytic residues [active] 1121451009631 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1121451009632 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1121451009633 putative DNA binding site [nucleotide binding]; other site 1121451009634 putative Zn2+ binding site [ion binding]; other site 1121451009635 AsnC family; Region: AsnC_trans_reg; pfam01037 1121451009636 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 1121451009637 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1121451009638 motif II; other site 1121451009639 ribulose bisphosphate carboxylase; Provisional; Region: PRK13475 1121451009640 Ribulose bisphosphate carboxylase large chain, Form II; Region: RuBisCO_large_II; cd08211 1121451009641 dimer interface [polypeptide binding]; other site 1121451009642 active site 1121451009643 catalytic residue [active] 1121451009644 metal binding site [ion binding]; metal-binding site 1121451009645 phosphoribulokinase; Provisional; Region: PRK07429 1121451009646 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 1121451009647 active site 1121451009648 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 1121451009649 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 1121451009650 putative active site [active] 1121451009651 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 1121451009652 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1121451009653 Walker A motif; other site 1121451009654 ATP binding site [chemical binding]; other site 1121451009655 Walker B motif; other site 1121451009656 arginine finger; other site 1121451009657 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1121451009658 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 1121451009659 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 1121451009660 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1121451009661 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 1121451009662 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 1121451009663 substrate binding site [chemical binding]; other site 1121451009664 hexamer interface [polypeptide binding]; other site 1121451009665 metal binding site [ion binding]; metal-binding site 1121451009666 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 1121451009667 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 1121451009668 intersubunit interface [polypeptide binding]; other site 1121451009669 active site 1121451009670 zinc binding site [ion binding]; other site 1121451009671 Na+ binding site [ion binding]; other site 1121451009672 phosphoglycerate kinase; Provisional; Region: pgk; PRK00073 1121451009673 Phosphoglycerate kinase; Region: PGK; pfam00162 1121451009674 substrate binding site [chemical binding]; other site 1121451009675 hinge regions; other site 1121451009676 ADP binding site [chemical binding]; other site 1121451009677 catalytic site [active] 1121451009678 transketolase; Reviewed; Region: PRK12753 1121451009679 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 1121451009680 TPP-binding site [chemical binding]; other site 1121451009681 dimer interface [polypeptide binding]; other site 1121451009682 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1121451009683 PYR/PP interface [polypeptide binding]; other site 1121451009684 dimer interface [polypeptide binding]; other site 1121451009685 TPP binding site [chemical binding]; other site 1121451009686 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1121451009687 EamA-like transporter family; Region: EamA; pfam00892 1121451009688 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1121451009689 EamA-like transporter family; Region: EamA; pfam00892 1121451009690 Protein of unknown function (DUF615); Region: DUF615; pfam04751 1121451009691 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1121451009692 EamA-like transporter family; Region: EamA; pfam00892 1121451009693 EamA-like transporter family; Region: EamA; pfam00892 1121451009694 Menaquinone biosynthesis; Region: VitK2_biosynth; cl17475 1121451009695 putative menaquinone biosynthesis protein, SCO4494 family; Region: mena_SCO4494; TIGR03700 1121451009696 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377 1121451009697 FeS/SAM binding site; other site 1121451009698 menaquinone biosynthesis protein, SCO4550 family; Region: mena_SCO4550; TIGR03699 1121451009699 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1121451009700 FeS/SAM binding site; other site 1121451009701 Menaquinone biosynthesis; Region: VitK2_biosynth; pfam02621 1121451009702 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1121451009703 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1121451009704 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 1121451009705 putative dimerization interface [polypeptide binding]; other site 1121451009706 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 1121451009707 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 1121451009708 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 1121451009709 alphaNTD - beta interaction site [polypeptide binding]; other site 1121451009710 alphaNTD homodimer interface [polypeptide binding]; other site 1121451009711 alphaNTD - beta' interaction site [polypeptide binding]; other site 1121451009712 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 1121451009713 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 1121451009714 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 1121451009715 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1121451009716 RNA binding surface [nucleotide binding]; other site 1121451009717 30S ribosomal protein S11; Validated; Region: PRK05309 1121451009718 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 1121451009719 30S ribosomal protein S13; Region: bact_S13; TIGR03631 1121451009720 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 1121451009721 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 1121451009722 active site 1121451009723 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 1121451009724 SecY translocase; Region: SecY; pfam00344 1121451009725 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 1121451009726 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 1121451009727 23S rRNA binding site [nucleotide binding]; other site 1121451009728 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 1121451009729 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 1121451009730 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 1121451009731 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 1121451009732 5S rRNA interface [nucleotide binding]; other site 1121451009733 L27 interface [polypeptide binding]; other site 1121451009734 23S rRNA interface [nucleotide binding]; other site 1121451009735 L5 interface [polypeptide binding]; other site 1121451009736 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 1121451009737 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1121451009738 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1121451009739 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 1121451009740 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 1121451009741 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 1121451009742 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 1121451009743 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 1121451009744 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 1121451009745 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 1121451009746 RNA binding site [nucleotide binding]; other site 1121451009747 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 1121451009748 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 1121451009749 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 1121451009750 23S rRNA interface [nucleotide binding]; other site 1121451009751 putative translocon interaction site; other site 1121451009752 signal recognition particle (SRP54) interaction site; other site 1121451009753 L23 interface [polypeptide binding]; other site 1121451009754 trigger factor interaction site; other site 1121451009755 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 1121451009756 23S rRNA interface [nucleotide binding]; other site 1121451009757 5S rRNA interface [nucleotide binding]; other site 1121451009758 putative antibiotic binding site [chemical binding]; other site 1121451009759 L25 interface [polypeptide binding]; other site 1121451009760 L27 interface [polypeptide binding]; other site 1121451009761 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 1121451009762 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 1121451009763 G-X-X-G motif; other site 1121451009764 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 1121451009765 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 1121451009766 putative translocon binding site; other site 1121451009767 protein-rRNA interface [nucleotide binding]; other site 1121451009768 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 1121451009769 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 1121451009770 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 1121451009771 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 1121451009772 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 1121451009773 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 1121451009774 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 1121451009775 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 1121451009776 elongation factor G; Reviewed; Region: PRK00007 1121451009777 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 1121451009778 G1 box; other site 1121451009779 putative GEF interaction site [polypeptide binding]; other site 1121451009780 GTP/Mg2+ binding site [chemical binding]; other site 1121451009781 Switch I region; other site 1121451009782 G2 box; other site 1121451009783 G3 box; other site 1121451009784 Switch II region; other site 1121451009785 G4 box; other site 1121451009786 G5 box; other site 1121451009787 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 1121451009788 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 1121451009789 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 1121451009790 30S ribosomal protein S7; Validated; Region: PRK05302 1121451009791 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 1121451009792 S17 interaction site [polypeptide binding]; other site 1121451009793 S8 interaction site; other site 1121451009794 16S rRNA interaction site [nucleotide binding]; other site 1121451009795 streptomycin interaction site [chemical binding]; other site 1121451009796 23S rRNA interaction site [nucleotide binding]; other site 1121451009797 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 1121451009798 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 1121451009799 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 1121451009800 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 1121451009801 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 1121451009802 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 1121451009803 RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998 1121451009804 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 1121451009805 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 1121451009806 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 1121451009807 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 1121451009808 DNA binding site [nucleotide binding] 1121451009809 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 1121451009810 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 1121451009811 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 1121451009812 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 1121451009813 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 1121451009814 RPB11 interaction site [polypeptide binding]; other site 1121451009815 RPB12 interaction site [polypeptide binding]; other site 1121451009816 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 1121451009817 RPB3 interaction site [polypeptide binding]; other site 1121451009818 RPB1 interaction site [polypeptide binding]; other site 1121451009819 RPB11 interaction site [polypeptide binding]; other site 1121451009820 RPB10 interaction site [polypeptide binding]; other site 1121451009821 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 1121451009822 core dimer interface [polypeptide binding]; other site 1121451009823 peripheral dimer interface [polypeptide binding]; other site 1121451009824 L10 interface [polypeptide binding]; other site 1121451009825 L11 interface [polypeptide binding]; other site 1121451009826 putative EF-Tu interaction site [polypeptide binding]; other site 1121451009827 putative EF-G interaction site [polypeptide binding]; other site 1121451009828 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 1121451009829 23S rRNA interface [nucleotide binding]; other site 1121451009830 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 1121451009831 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 1121451009832 mRNA/rRNA interface [nucleotide binding]; other site 1121451009833 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 1121451009834 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 1121451009835 23S rRNA interface [nucleotide binding]; other site 1121451009836 L7/L12 interface [polypeptide binding]; other site 1121451009837 putative thiostrepton binding site; other site 1121451009838 L25 interface [polypeptide binding]; other site 1121451009839 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 1121451009840 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 1121451009841 putative homodimer interface [polypeptide binding]; other site 1121451009842 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 1121451009843 heterodimer interface [polypeptide binding]; other site 1121451009844 homodimer interface [polypeptide binding]; other site 1121451009845 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK05740 1121451009846 elongation factor Tu; Reviewed; Region: PRK00049 1121451009847 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 1121451009848 G1 box; other site 1121451009849 GEF interaction site [polypeptide binding]; other site 1121451009850 GTP/Mg2+ binding site [chemical binding]; other site 1121451009851 Switch I region; other site 1121451009852 G2 box; other site 1121451009853 G3 box; other site 1121451009854 Switch II region; other site 1121451009855 G4 box; other site 1121451009856 G5 box; other site 1121451009857 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 1121451009858 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 1121451009859 Antibiotic Binding Site [chemical binding]; other site 1121451009860 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 1121451009861 tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042 1121451009862 FMN binding site [chemical binding]; other site 1121451009863 active site 1121451009864 catalytic residues [active] 1121451009865 substrate binding site [chemical binding]; other site 1121451009866 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 1121451009867 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1121451009868 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121451009869 active site 1121451009870 phosphorylation site [posttranslational modification] 1121451009871 intermolecular recognition site; other site 1121451009872 dimerization interface [polypeptide binding]; other site 1121451009873 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 1121451009874 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 1121451009875 Cl- selectivity filter; other site 1121451009876 Cl- binding residues [ion binding]; other site 1121451009877 pore gating glutamate residue; other site 1121451009878 dimer interface [polypeptide binding]; other site 1121451009879 FOG: CBS domain [General function prediction only]; Region: COG0517 1121451009880 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with either the SpoIVFB domain (sporulation protein, stage IV cell wall formation, F locus, promoter-distal B) or the chloride channel protein EriC; Region: CBS_pair_SpoIVFB_EriC_assoc2; cd04613 1121451009881 HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis. HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197 1121451009882 dimerization interface [polypeptide binding]; other site 1121451009883 hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124 1121451009884 ATP binding site [chemical binding]; other site 1121451009885 hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062 1121451009886 hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075 1121451009887 Response regulator receiver domain; Region: Response_reg; pfam00072 1121451009888 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121451009889 active site 1121451009890 phosphorylation site [posttranslational modification] 1121451009891 intermolecular recognition site; other site 1121451009892 dimerization interface [polypeptide binding]; other site 1121451009893 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 1121451009894 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121451009895 active site 1121451009896 phosphorylation site [posttranslational modification] 1121451009897 intermolecular recognition site; other site 1121451009898 dimerization interface [polypeptide binding]; other site 1121451009899 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1121451009900 DNA-binding site [nucleotide binding]; DNA binding site 1121451009901 RNA-binding motif; other site 1121451009902 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 1121451009903 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 1121451009904 HflX GTPase family; Region: HflX; cd01878 1121451009905 G1 box; other site 1121451009906 GTP/Mg2+ binding site [chemical binding]; other site 1121451009907 Switch I region; other site 1121451009908 G2 box; other site 1121451009909 G3 box; other site 1121451009910 Switch II region; other site 1121451009911 G4 box; other site 1121451009912 G5 box; other site 1121451009913 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 1121451009914 purine monophosphate binding site [chemical binding]; other site 1121451009915 dimer interface [polypeptide binding]; other site 1121451009916 putative catalytic residues [active] 1121451009917 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1121451009918 binding surface 1121451009919 TPR motif; other site 1121451009920 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1121451009921 binding surface 1121451009922 TPR motif; other site 1121451009923 flagellar basal body rod protein FlgB; Provisional; Region: flgB; PRK12621 1121451009924 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182 1121451009925 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 1121451009926 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1121451009927 Flagellar hook-basal body complex protein FliE; Region: FliE; pfam02049 1121451009928 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 1121451009929 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 1121451009930 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 1121451009931 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 1121451009932 MgtE intracellular N domain; Region: MgtE_N; cl15244 1121451009933 FliG C-terminal domain; Region: FliG_C; pfam01706 1121451009934 Flagellar assembly protein FliH; Region: FliH; pfam02108 1121451009935 flagellar protein export ATPase FliI; Region: FliI_clade1; TIGR03496 1121451009936 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 1121451009937 Walker A motif/ATP binding site; other site 1121451009938 Walker B motif; other site 1121451009939 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1121451009940 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1121451009941 substrate binding pocket [chemical binding]; other site 1121451009942 membrane-bound complex binding site; other site 1121451009943 hinge residues; other site 1121451009944 Response regulator receiver domain; Region: Response_reg; pfam00072 1121451009945 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121451009946 active site 1121451009947 phosphorylation site [posttranslational modification] 1121451009948 intermolecular recognition site; other site 1121451009949 dimerization interface [polypeptide binding]; other site 1121451009950 Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331 1121451009951 hypothetical protein; Provisional; Region: PRK08328 1121451009952 Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cl17196 1121451009953 ATP binding site [chemical binding]; other site 1121451009954 substrate interface [chemical binding]; other site 1121451009955 ThiS family; Region: ThiS; pfam02597 1121451009956 charged pocket; other site 1121451009957 hydrophobic patch; other site 1121451009958 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 1121451009959 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1121451009960 putative molybdenum transport ATP-binding protein ModF; Provisional; Region: PRK10938 1121451009961 Walker A/P-loop; other site 1121451009962 ATP binding site [chemical binding]; other site 1121451009963 ABC transporter signature motif; other site 1121451009964 Walker B; other site 1121451009965 D-loop; other site 1121451009966 H-loop/switch region; other site 1121451009967 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1121451009968 Walker A/P-loop; other site 1121451009969 ATP binding site [chemical binding]; other site 1121451009970 Q-loop/lid; other site 1121451009971 ABC transporter signature motif; other site 1121451009972 Walker B; other site 1121451009973 D-loop; other site 1121451009974 H-loop/switch region; other site 1121451009975 Uncharacterized conserved protein [Function unknown]; Region: COG2006 1121451009976 Domain of unknown function (DUF362); Region: DUF362; pfam04015 1121451009977 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068 1121451009978 Acylphosphatase; Region: Acylphosphatase; pfam00708 1121451009979 HypF finger; Region: zf-HYPF; pfam07503 1121451009980 HypF finger; Region: zf-HYPF; pfam07503 1121451009981 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 1121451009982 Response regulator receiver domain; Region: Response_reg; pfam00072 1121451009983 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121451009984 active site 1121451009985 phosphorylation site [posttranslational modification] 1121451009986 intermolecular recognition site; other site 1121451009987 dimerization interface [polypeptide binding]; other site 1121451009988 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1121451009989 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 1121451009990 dimer interface [polypeptide binding]; other site 1121451009991 phosphorylation site [posttranslational modification] 1121451009992 Response regulator receiver domain; Region: Response_reg; pfam00072 1121451009993 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121451009994 active site 1121451009995 phosphorylation site [posttranslational modification] 1121451009996 intermolecular recognition site; other site 1121451009997 dimerization interface [polypeptide binding]; other site 1121451009998 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1121451009999 dimer interface [polypeptide binding]; other site 1121451010000 phosphorylation site [posttranslational modification] 1121451010001 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1121451010002 ATP binding site [chemical binding]; other site 1121451010003 Mg2+ binding site [ion binding]; other site 1121451010004 G-X-G motif; other site 1121451010005 Cytidylate kinase-like family; Region: Cytidylate_kin2; pfam13189 1121451010006 Response regulator receiver domain; Region: Response_reg; pfam00072 1121451010007 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121451010008 active site 1121451010009 phosphorylation site [posttranslational modification] 1121451010010 intermolecular recognition site; other site 1121451010011 dimerization interface [polypeptide binding]; other site 1121451010012 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 1121451010013 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 1121451010014 Sulfate transporter family; Region: Sulfate_transp; pfam00916 1121451010015 Sulfate transporter family; Region: Sulfate_transp; pfam00916 1121451010016 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 1121451010017 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 1121451010018 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1121451010019 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1121451010020 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 1121451010021 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1121451010022 catalytic residue [active] 1121451010023 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1121451010024 FAD binding domain; Region: FAD_binding_4; pfam01565 1121451010025 FAD linked oxidases, C-terminal domain; Region: FAD-oxidase_C; pfam02913 1121451010026 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 1121451010027 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1121451010028 Cysteine-rich domain; Region: CCG; pfam02754 1121451010029 Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652 1121451010030 YceG-like family; Region: YceG; pfam02618 1121451010031 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 1121451010032 dimerization interface [polypeptide binding]; other site 1121451010033 Predicted permease; Region: DUF318; cl17795 1121451010034 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1121451010035 dimerization interface [polypeptide binding]; other site 1121451010036 putative DNA binding site [nucleotide binding]; other site 1121451010037 putative Zn2+ binding site [ion binding]; other site 1121451010038 Putative molybdenum carrier; Region: MoCo_carrier; pfam12694 1121451010039 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1121451010040 dimerization interface [polypeptide binding]; other site 1121451010041 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1121451010042 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1121451010043 putative active site [active] 1121451010044 heme pocket [chemical binding]; other site 1121451010045 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1121451010046 dimer interface [polypeptide binding]; other site 1121451010047 phosphorylation site [posttranslational modification] 1121451010048 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1121451010049 ATP binding site [chemical binding]; other site 1121451010050 Mg2+ binding site [ion binding]; other site 1121451010051 G-X-G motif; other site 1121451010052 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1121451010053 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121451010054 active site 1121451010055 phosphorylation site [posttranslational modification] 1121451010056 intermolecular recognition site; other site 1121451010057 dimerization interface [polypeptide binding]; other site 1121451010058 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 1121451010059 Type I periplasmic binding domain of uncharacterized extracellular ligand-binding proteins; Region: PBP1_STKc_like; cd06326 1121451010060 putative ligand binding site [chemical binding]; other site 1121451010061 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1121451010062 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1121451010063 Zn2+ binding site [ion binding]; other site 1121451010064 Mg2+ binding site [ion binding]; other site 1121451010065 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1121451010066 Response regulator receiver domain; Region: Response_reg; pfam00072 1121451010067 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121451010068 active site 1121451010069 phosphorylation site [posttranslational modification] 1121451010070 intermolecular recognition site; other site 1121451010071 dimerization interface [polypeptide binding]; other site 1121451010072 Type I periplasmic binding domain of uncharacterized extracellular ligand-binding proteins; Region: PBP1_STKc_like; cd06326 1121451010073 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 1121451010074 putative ligand binding site [chemical binding]; other site 1121451010075 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 1121451010076 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1121451010077 putative active site [active] 1121451010078 heme pocket [chemical binding]; other site 1121451010079 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1121451010080 dimer interface [polypeptide binding]; other site 1121451010081 phosphorylation site [posttranslational modification] 1121451010082 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1121451010083 ATP binding site [chemical binding]; other site 1121451010084 Mg2+ binding site [ion binding]; other site 1121451010085 G-X-G motif; other site 1121451010086 Response regulator receiver domain; Region: Response_reg; pfam00072 1121451010087 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121451010088 active site 1121451010089 phosphorylation site [posttranslational modification] 1121451010090 intermolecular recognition site; other site 1121451010091 dimerization interface [polypeptide binding]; other site 1121451010092 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1121451010093 anti sigma factor interaction site; other site 1121451010094 regulatory phosphorylation site [posttranslational modification]; other site 1121451010095 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1121451010096 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1121451010097 ABC-ATPase subunit interface; other site 1121451010098 dimer interface [polypeptide binding]; other site 1121451010099 putative PBP binding regions; other site 1121451010100 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 1121451010101 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 1121451010102 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 1121451010103 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 1121451010104 tetramer interface [polypeptide binding]; other site 1121451010105 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1121451010106 catalytic residue [active] 1121451010107 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ACT14924; Region: LPLAT_ACT14924-like; cd07986 1121451010108 putative acyl-acceptor binding pocket; other site 1121451010109 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; pfam13444 1121451010110 N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853 1121451010111 malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402 1121451010112 Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325 1121451010113 catalytic site [active] 1121451010114 active site 1121451010115 4-alpha-glucanotransferase; Provisional; Region: PRK14508 1121451010116 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1121451010117 S-adenosylmethionine binding site [chemical binding]; other site 1121451010118 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 1121451010119 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900 1121451010120 GT_2_like_a represents a glycosyltransferase family-2 subfamily with unknown function; Region: GT_2_like_a; cd02522 1121451010121 transferase 2, rSAM/selenodomain-associated; Region: glyco_like_mftF; TIGR04283 1121451010122 Probable Catalytic site; other site 1121451010123 transferase 1, rSAM/selenodomain-associated; Region: glyco_like_cofC; TIGR04282 1121451010124 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 1121451010125 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 1121451010126 trmE is a tRNA modification GTPase; Region: trmE; cd04164 1121451010127 G1 box; other site 1121451010128 GTP/Mg2+ binding site [chemical binding]; other site 1121451010129 Switch I region; other site 1121451010130 G2 box; other site 1121451010131 Switch II region; other site 1121451010132 G3 box; other site 1121451010133 G4 box; other site 1121451010134 G5 box; other site 1121451010135 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 1121451010136 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 1121451010137 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 1121451010138 G-X-X-G motif; other site 1121451010139 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 1121451010140 RxxxH motif; other site 1121451010141 membrane protein insertase; Provisional; Region: PRK01318 1121451010142 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 1121451010143 Ribonuclease P; Region: Ribonuclease_P; pfam00825 1121451010144 Ribosomal protein L34; Region: Ribosomal_L34; cl00370 1121451010145 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 1121451010146 hypothetical protein; Provisional; Region: PRK04334 1121451010147 Domain of unknown function DUF77; Region: DUF77; pfam01910 1121451010148 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1121451010149 FeS/SAM binding site; other site 1121451010150 Domain of unknown function (DUF4008); Region: DUF4008; pfam13186 1121451010151 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 1121451010152 homodimer interface [polypeptide binding]; other site 1121451010153 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 1121451010154 active site pocket [active] 1121451010155 Beta-lactamase; Region: Beta-lactamase; pfam00144 1121451010156 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1121451010157 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1121451010158 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1121451010159 Walker A/P-loop; other site 1121451010160 ATP binding site [chemical binding]; other site 1121451010161 Q-loop/lid; other site 1121451010162 ABC transporter signature motif; other site 1121451010163 Walker B; other site 1121451010164 D-loop; other site 1121451010165 H-loop/switch region; other site 1121451010166 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1121451010167 dimer interface [polypeptide binding]; other site 1121451010168 conserved gate region; other site 1121451010169 putative PBP binding loops; other site 1121451010170 ABC-ATPase subunit interface; other site 1121451010171 PBP superfamily domain; Region: PBP_like_2; pfam12849 1121451010172 FdhD/NarQ family; Region: FdhD-NarQ; pfam02634 1121451010173 Protein involved in formate dehydrogenase formation; Region: FdhE; pfam04216 1121451010174 formate dehydrogenase accessory protein FdhE; Region: FdhE; TIGR01562 1121451010175 molybdenum cofactor biosynthesis protein A, bacterial; Region: moaA; TIGR02666 1121451010176 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1121451010177 FeS/SAM binding site; other site 1121451010178 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 1121451010179 Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760 1121451010180 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; cl01481 1121451010181 Cache domain; Region: Cache_1; pfam02743 1121451010182 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1121451010183 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1121451010184 metal binding site [ion binding]; metal-binding site 1121451010185 active site 1121451010186 I-site; other site 1121451010187 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 1121451010188 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1121451010189 Walker A motif; other site 1121451010190 ATP binding site [chemical binding]; other site 1121451010191 Walker B motif; other site 1121451010192 arginine finger; other site 1121451010193 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 1121451010194 Holliday junction DNA helicase RuvA; Provisional; Region: ruvA; PRK14602 1121451010195 RuvA N terminal domain; Region: RuvA_N; pfam01330 1121451010196 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 1121451010197 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 1121451010198 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 1121451010199 active site 1121451010200 putative DNA-binding cleft [nucleotide binding]; other site 1121451010201 dimer interface [polypeptide binding]; other site 1121451010202 hypothetical protein; Validated; Region: PRK00110 1121451010203 23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293 1121451010204 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1121451010205 S-adenosylmethionine binding site [chemical binding]; other site 1121451010206 DUF based on E. rectale Gene description (DUF3880); Region: DUF3880; pfam12996 1121451010207 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 1121451010208 outer membrane lipoprotein; Provisional; Region: PRK11023 1121451010209 BON domain; Region: BON; pfam04972 1121451010210 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1121451010211 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1121451010212 DNA-binding site [nucleotide binding]; DNA binding site 1121451010213 FCD domain; Region: FCD; pfam07729 1121451010214 Cache domain; Region: Cache_1; pfam02743 1121451010215 HAMP domain; Region: HAMP; pfam00672 1121451010216 dimerization interface [polypeptide binding]; other site 1121451010217 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1121451010218 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1121451010219 dimer interface [polypeptide binding]; other site 1121451010220 putative CheW interface [polypeptide binding]; other site 1121451010221 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1121451010222 dimerization interface [polypeptide binding]; other site 1121451010223 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1121451010224 PAS fold; Region: PAS_3; pfam08447 1121451010225 putative active site [active] 1121451010226 heme pocket [chemical binding]; other site 1121451010227 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 1121451010228 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1121451010229 dimer interface [polypeptide binding]; other site 1121451010230 phosphorylation site [posttranslational modification] 1121451010231 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1121451010232 ATP binding site [chemical binding]; other site 1121451010233 Mg2+ binding site [ion binding]; other site 1121451010234 G-X-G motif; other site 1121451010235 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1121451010236 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 1121451010237 AsnC family; Region: AsnC_trans_reg; pfam01037 1121451010238 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 1121451010239 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 1121451010240 substrate-cofactor binding pocket; other site 1121451010241 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1121451010242 catalytic residue [active] 1121451010243 L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396 1121451010244 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1121451010245 NAD(P) binding site [chemical binding]; other site 1121451010246 AsmA family; Region: AsmA; pfam05170 1121451010247 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 1121451010248 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1121451010249 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1121451010250 dimer interface [polypeptide binding]; other site 1121451010251 putative CheW interface [polypeptide binding]; other site 1121451010252 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 1121451010253 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1121451010254 DNA binding residues [nucleotide binding] 1121451010255 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 1121451010256 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 1121451010257 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1121451010258 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1121451010259 protein binding site [polypeptide binding]; other site 1121451010260 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1121451010261 protein binding site [polypeptide binding]; other site 1121451010262 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK14615 1121451010263 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 1121451010264 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 1121451010265 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 1121451010266 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1121451010267 active site 1121451010268 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 1121451010269 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 1121451010270 5S rRNA interface [nucleotide binding]; other site 1121451010271 CTC domain interface [polypeptide binding]; other site 1121451010272 L16 interface [polypeptide binding]; other site 1121451010273 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 1121451010274 putative active site [active] 1121451010275 catalytic residue [active] 1121451010276 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588 1121451010277 transcription termination factor Rho; Provisional; Region: rho; PRK09376 1121451010278 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 1121451010279 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 1121451010280 RNA binding site [nucleotide binding]; other site 1121451010281 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 1121451010282 multimer interface [polypeptide binding]; other site 1121451010283 Walker A motif; other site 1121451010284 ATP binding site [chemical binding]; other site 1121451010285 Walker B motif; other site 1121451010286 Peptidase family M48; Region: Peptidase_M48; pfam01435 1121451010287 TPR repeat; Region: TPR_11; pfam13414 1121451010288 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1121451010289 binding surface 1121451010290 TPR motif; other site 1121451010291 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 1121451010292 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 1121451010293 active site 1121451010294 Riboflavin kinase; Region: Flavokinase; pfam01687 1121451010295 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 1121451010296 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 1121451010297 Cl- selectivity filter; other site 1121451010298 Cl- binding residues [ion binding]; other site 1121451010299 pore gating glutamate residue; other site 1121451010300 dimer interface [polypeptide binding]; other site 1121451010301 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with either the SpoIVFB domain (sporulation protein, stage IV cell wall formation, F locus, promoter-distal B) or the chloride channel protein EriC; Region: CBS_pair_SpoIVFB_EriC_assoc2; cd04613 1121451010302 FOG: CBS domain [General function prediction only]; Region: COG0517 1121451010303 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 1121451010304 active site 1121451010305 HslU subunit interaction site [polypeptide binding]; other site 1121451010306 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 1121451010307 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1121451010308 Walker A motif; other site 1121451010309 ATP binding site [chemical binding]; other site 1121451010310 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 1121451010311 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1121451010312 TPR repeat; Region: TPR_11; pfam13414 1121451010313 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1121451010314 binding surface 1121451010315 TPR motif; other site 1121451010316 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1121451010317 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 1121451010318 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 1121451010319 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1121451010320 Uncharacterized family of ferritin-like proteins found in archaea and bacteria; Region: Ferritin_like_AB; cd01045 1121451010321 diiron binding motif [ion binding]; other site 1121451010322 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086 1121451010323 putative binding surface; other site 1121451010324 active site 1121451010325 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 1121451010326 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1121451010327 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1121451010328 homodimer interface [polypeptide binding]; other site 1121451010329 catalytic residue [active] 1121451010330 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 1121451010331 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1121451010332 dimerization interface [polypeptide binding]; other site 1121451010333 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1121451010334 dimer interface [polypeptide binding]; other site 1121451010335 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 1121451010336 putative CheW interface [polypeptide binding]; other site 1121451010337 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 1121451010338 Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_12; cd06347 1121451010339 putative ligand binding site [chemical binding]; other site 1121451010340 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 1121451010341 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1121451010342 TM-ABC transporter signature motif; other site 1121451010343 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 1121451010344 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 1121451010345 TM-ABC transporter signature motif; other site 1121451010346 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 1121451010347 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 1121451010348 Walker A/P-loop; other site 1121451010349 ATP binding site [chemical binding]; other site 1121451010350 Q-loop/lid; other site 1121451010351 ABC transporter signature motif; other site 1121451010352 Walker B; other site 1121451010353 D-loop; other site 1121451010354 H-loop/switch region; other site 1121451010355 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 1121451010356 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 1121451010357 Walker A/P-loop; other site 1121451010358 ATP binding site [chemical binding]; other site 1121451010359 Q-loop/lid; other site 1121451010360 ABC transporter signature motif; other site 1121451010361 Walker B; other site 1121451010362 D-loop; other site 1121451010363 H-loop/switch region; other site 1121451010364 hypothetical protein; Provisional; Region: PRK10578 1121451010365 UPF0126 domain; Region: UPF0126; pfam03458 1121451010366 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 1121451010367 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 1121451010368 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 1121451010369 putative active site [active] 1121451010370 putative substrate binding site [chemical binding]; other site 1121451010371 putative cosubstrate binding site; other site 1121451010372 catalytic site [active] 1121451010373 Radical SAM superfamily; Region: Radical_SAM; pfam04055 1121451010374 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1121451010375 FeS/SAM binding site; other site 1121451010376 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK08270 1121451010377 ATP cone domain; Region: ATP-cone; pfam03477 1121451010378 Class III ribonucleotide reductase; Region: RNR_III; cd01675 1121451010379 effector binding site; other site 1121451010380 active site 1121451010381 Zn binding site [ion binding]; other site 1121451010382 glycine loop; other site 1121451010383 Response regulator receiver domain; Region: Response_reg; pfam00072 1121451010384 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121451010385 active site 1121451010386 phosphorylation site [posttranslational modification] 1121451010387 intermolecular recognition site; other site 1121451010388 dimerization interface [polypeptide binding]; other site 1121451010389 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 1121451010390 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 1121451010391 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 1121451010392 EAL domain; Region: EAL; pfam00563 1121451010393 Predicted signal transduction protein containing EAL and modified HD-GYP domains [Signal transduction mechanisms]; Region: COG3434 1121451010394 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 1121451010395 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1121451010396 Domain of unknown function (DUF1844); Region: DUF1844; pfam08899 1121451010397 DNA polymerase I; Provisional; Region: PRK05755 1121451010398 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 1121451010399 active site 1121451010400 metal binding site 1 [ion binding]; metal-binding site 1121451010401 putative 5' ssDNA interaction site; other site 1121451010402 metal binding site 3; metal-binding site 1121451010403 metal binding site 2 [ion binding]; metal-binding site 1121451010404 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 1121451010405 putative DNA binding site [nucleotide binding]; other site 1121451010406 putative metal binding site [ion binding]; other site 1121451010407 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 1121451010408 active site 1121451010409 substrate binding site [chemical binding]; other site 1121451010410 catalytic site [active] 1121451010411 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 1121451010412 active site 1121451010413 DNA binding site [nucleotide binding] 1121451010414 catalytic site [active] 1121451010415 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 1121451010416 DHH family; Region: DHH; pfam01368 1121451010417 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1121451010418 Walker A motif; other site 1121451010419 ATP binding site [chemical binding]; other site 1121451010420 Walker B motif; other site 1121451010421 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 1121451010422 PHP family phosphoesterase with a Zn ribbon [General function prediction only]; Region: COG1379 1121451010423 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 1121451010424 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 1121451010425 Part of AAA domain; Region: AAA_19; pfam13245 1121451010426 Family description; Region: UvrD_C_2; pfam13538 1121451010427 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 1121451010428 zinc transporter ZupT; Provisional; Region: PRK04201 1121451010429 ZIP Zinc transporter; Region: Zip; pfam02535 1121451010430 putative cation:proton antiport protein; Provisional; Region: PRK10669 1121451010431 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 1121451010432 TrkA-N domain; Region: TrkA_N; pfam02254 1121451010433 TrkA-C domain; Region: TrkA_C; pfam02080 1121451010434 DnaK suppressor protein [Signal transduction mechanisms]; Region: DksA; COG1734 1121451010435 Cache domain; Region: Cache_1; pfam02743 1121451010436 HAMP domain; Region: HAMP; pfam00672 1121451010437 PAS domain; Region: PAS_9; pfam13426 1121451010438 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1121451010439 putative active site [active] 1121451010440 heme pocket [chemical binding]; other site 1121451010441 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1121451010442 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1121451010443 dimer interface [polypeptide binding]; other site 1121451010444 putative CheW interface [polypeptide binding]; other site 1121451010445 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 1121451010446 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1121451010447 Walker A/P-loop; other site 1121451010448 ATP binding site [chemical binding]; other site 1121451010449 Q-loop/lid; other site 1121451010450 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1121451010451 ABC transporter; Region: ABC_tran_2; pfam12848 1121451010452 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1121451010453 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1121451010454 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1121451010455 metal binding site [ion binding]; metal-binding site 1121451010456 active site 1121451010457 I-site; other site 1121451010458 PAS domain S-box; Region: sensory_box; TIGR00229 1121451010459 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1121451010460 putative active site [active] 1121451010461 heme pocket [chemical binding]; other site 1121451010462 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1121451010463 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1121451010464 metal binding site [ion binding]; metal-binding site 1121451010465 active site 1121451010466 I-site; other site 1121451010467 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1121451010468 VacJ like lipoprotein; Region: VacJ; cl01073 1121451010469 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 1121451010470 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_2; cd03138 1121451010471 conserved cys residue [active] 1121451010472 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1121451010473 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1121451010474 Isochorismatase family; Region: Isochorismatase; pfam00857 1121451010475 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 1121451010476 catalytic triad [active] 1121451010477 conserved cis-peptide bond; other site 1121451010478 Domain of unknown function (DUF4198); Region: DUF4198; pfam10670 1121451010479 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1121451010480 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 1121451010481 metal binding site [ion binding]; metal-binding site 1121451010482 putative dimer interface [polypeptide binding]; other site 1121451010483 Protein of unknown function (DUF3100); Region: DUF3100; pfam11299 1121451010484 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1121451010485 active site 1121451010486 Predicted membrane protein (DUF2335); Region: DUF2335; pfam10097 1121451010487 Peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: MsrA; COG0225 1121451010488 methionine sulfoxide reductase B; Provisional; Region: PRK00222 1121451010489 SelR domain; Region: SelR; pfam01641 1121451010490 D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813 1121451010491 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_2; cd06310 1121451010492 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 1121451010493 putative ligand binding site [chemical binding]; other site 1121451010494 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466 1121451010495 uncharacterized subgroup of aldehyde reductase and flavonoid reductase related proteins, extended (e) SDRs; Region: AR_FR_like_1_SDR_e; cd05228 1121451010496 putative NADP binding site [chemical binding]; other site 1121451010497 putative substrate binding site [chemical binding]; other site 1121451010498 active site 1121451010499 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1121451010500 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121451010501 active site 1121451010502 phosphorylation site [posttranslational modification] 1121451010503 intermolecular recognition site; other site 1121451010504 dimerization interface [polypeptide binding]; other site 1121451010505 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1121451010506 binding surface 1121451010507 TPR motif; other site 1121451010508 TPR repeat; Region: TPR_11; pfam13414 1121451010509 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1121451010510 binding surface 1121451010511 TPR motif; other site 1121451010512 TPR repeat; Region: TPR_11; pfam13414 1121451010513 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 1121451010514 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1121451010515 DNA binding site [nucleotide binding] 1121451010516 active site 1121451010517 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1121451010518 dimerization interface [polypeptide binding]; other site 1121451010519 PAS domain S-box; Region: sensory_box; TIGR00229 1121451010520 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1121451010521 putative active site [active] 1121451010522 heme pocket [chemical binding]; other site 1121451010523 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1121451010524 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1121451010525 metal binding site [ion binding]; metal-binding site 1121451010526 active site 1121451010527 I-site; other site 1121451010528 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1121451010529 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 1121451010530 Uncharacterized conserved protein [Function unknown]; Region: COG1359 1121451010531 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1121451010532 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 1121451010533 putative substrate translocation pore; other site 1121451010534 Protein of unknown function (DUF3365); Region: DUF3365; pfam11845 1121451010535 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 1121451010536 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1121451010537 putative active site [active] 1121451010538 heme pocket [chemical binding]; other site 1121451010539 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1121451010540 ATP binding site [chemical binding]; other site 1121451010541 Mg2+ binding site [ion binding]; other site 1121451010542 G-X-G motif; other site 1121451010543 Ion channel; Region: Ion_trans_2; pfam07885 1121451010544 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 1121451010545 TrkA-N domain; Region: TrkA_N; pfam02254 1121451010546 TrkA-C domain; Region: TrkA_C; pfam02080 1121451010547 Predicted membrane protein [Function unknown]; Region: COG3152 1121451010548 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1121451010549 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1121451010550 dimer interface [polypeptide binding]; other site 1121451010551 putative CheW interface [polypeptide binding]; other site 1121451010552 Hemerythrin; Region: Hemerythrin; cd12107 1121451010553 Fe binding site [ion binding]; other site 1121451010554 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1121451010555 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1121451010556 dimerization interface [polypeptide binding]; other site 1121451010557 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1121451010558 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1121451010559 metal binding site [ion binding]; metal-binding site 1121451010560 active site 1121451010561 I-site; other site 1121451010562 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 1121451010563 Periplasmic binding component of a family of basic membrane lipoproteins from Borrelia and various putative lipoproteins from other bacteria; Region: PBP1_BmpA_like; cd06304 1121451010564 ligand binding site [chemical binding]; other site 1121451010565 Peroxiredoxin (PRX) family, AhpE-like subfamily; composed of proteins similar to Mycobacterium tuberculosis AhpE. AhpE is described as a 1-cys PRX because of the absence of a resolving cysteine. The structure and sequence of AhpE, however, show greater...; Region: PRX_AhpE_like; cd03018 1121451010566 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 1121451010567 dimer interface [polypeptide binding]; other site 1121451010568 catalytic triad [active] 1121451010569 Protein of unknown function, DUF481; Region: DUF481; pfam04338 1121451010570 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 1121451010571 ApbE family; Region: ApbE; pfam02424 1121451010572 Putative Fe-S cluster; Region: FeS; cl17515 1121451010573 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 1121451010574 4Fe-4S binding domain; Region: Fer4; pfam00037 1121451010575 dihydropyrimidine dehydrogenase subunit A; Provisional; Region: PRK11749 1121451010576 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1121451010577 electron transport complex, RnfABCDGE type, A subunit; Region: rnfA; TIGR01943 1121451010578 electron transport complex RsxE subunit; Provisional; Region: PRK12405 1121451010579 FMN-binding domain; Region: FMN_bind; cl01081 1121451010580 NQR2, RnfD, RnfE family; Region: NQR2_RnfD_RnfE; pfam03116 1121451010581 electron transport complex, RnfABCDGE type, C subunit; Region: rnfC; TIGR01945 1121451010582 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1121451010583 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168 1121451010584 heme-binding residues [chemical binding]; other site 1121451010585 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 1121451010586 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1121451010587 dimerization interface [polypeptide binding]; other site 1121451010588 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1121451010589 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1121451010590 dimer interface [polypeptide binding]; other site 1121451010591 putative CheW interface [polypeptide binding]; other site 1121451010592 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1121451010593 TMAO reductase system periplasmic protein TorT; Region: TMAO_TorT; TIGR02955 1121451010594 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1121451010595 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1121451010596 substrate binding pocket [chemical binding]; other site 1121451010597 membrane-bound complex binding site; other site 1121451010598 hinge residues; other site 1121451010599 PAS domain S-box; Region: sensory_box; TIGR00229 1121451010600 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1121451010601 putative active site [active] 1121451010602 heme pocket [chemical binding]; other site 1121451010603 PAS domain S-box; Region: sensory_box; TIGR00229 1121451010604 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1121451010605 putative active site [active] 1121451010606 heme pocket [chemical binding]; other site 1121451010607 GAF domain; Region: GAF_2; pfam13185 1121451010608 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1121451010609 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1121451010610 PAS fold; Region: PAS_3; pfam08447 1121451010611 putative active site [active] 1121451010612 heme pocket [chemical binding]; other site 1121451010613 PAS fold; Region: PAS_4; pfam08448 1121451010614 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1121451010615 putative active site [active] 1121451010616 heme pocket [chemical binding]; other site 1121451010617 PAS domain S-box; Region: sensory_box; TIGR00229 1121451010618 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1121451010619 putative active site [active] 1121451010620 heme pocket [chemical binding]; other site 1121451010621 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1121451010622 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1121451010623 metal binding site [ion binding]; metal-binding site 1121451010624 active site 1121451010625 I-site; other site 1121451010626 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390 1121451010627 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4619 1121451010628 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 1121451010629 Walker A/P-loop; other site 1121451010630 ATP binding site [chemical binding]; other site 1121451010631 Q-loop/lid; other site 1121451010632 ABC transporter signature motif; other site 1121451010633 Walker B; other site 1121451010634 D-loop; other site 1121451010635 H-loop/switch region; other site 1121451010636 Peptidase family M48; Region: Peptidase_M48; pfam01435 1121451010637 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1121451010638 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1121451010639 binding surface 1121451010640 TPR motif; other site 1121451010641 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1121451010642 malate synthase G; Provisional; Region: PRK02999 1121451010643 active site 1121451010644 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1121451010645 nitrogen fixation negative regulator NifL; Region: nifL_nitrog; TIGR02938 1121451010646 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1121451010647 putative active site [active] 1121451010648 heme pocket [chemical binding]; other site 1121451010649 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1121451010650 putative active site [active] 1121451010651 heme pocket [chemical binding]; other site 1121451010652 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1121451010653 dimer interface [polypeptide binding]; other site 1121451010654 phosphorylation site [posttranslational modification] 1121451010655 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1121451010656 ATP binding site [chemical binding]; other site 1121451010657 Mg2+ binding site [ion binding]; other site 1121451010658 G-X-G motif; other site 1121451010659 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 1121451010660 nucleotide binding site [chemical binding]; other site 1121451010661 substrate binding site [chemical binding]; other site 1121451010662 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 1121451010663 Sulfate transporter family; Region: Sulfate_transp; pfam00916 1121451010664 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1121451010665 putative trimer interface [polypeptide binding]; other site 1121451010666 putative CoA binding site [chemical binding]; other site 1121451010667 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 1121451010668 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 1121451010669 PAS fold; Region: PAS; pfam00989 1121451010670 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1121451010671 putative active site [active] 1121451010672 heme pocket [chemical binding]; other site 1121451010673 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 1121451010674 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 1121451010675 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 1121451010676 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1121451010677 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1121451010678 dimer interface [polypeptide binding]; other site 1121451010679 conserved gate region; other site 1121451010680 putative PBP binding loops; other site 1121451010681 ABC-ATPase subunit interface; other site 1121451010682 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1121451010683 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1121451010684 Walker A/P-loop; other site 1121451010685 ATP binding site [chemical binding]; other site 1121451010686 Q-loop/lid; other site 1121451010687 ABC transporter signature motif; other site 1121451010688 Walker B; other site 1121451010689 D-loop; other site 1121451010690 H-loop/switch region; other site 1121451010691 benzoyl-CoA reductase, subunit C; Region: benz_CoA_red_C; TIGR02263 1121451010692 2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050 1121451010693 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 1121451010694 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1121451010695 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1121451010696 dimerization interface [polypeptide binding]; other site 1121451010697 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1121451010698 dimer interface [polypeptide binding]; other site 1121451010699 phosphorylation site [posttranslational modification] 1121451010700 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1121451010701 ATP binding site [chemical binding]; other site 1121451010702 Mg2+ binding site [ion binding]; other site 1121451010703 G-X-G motif; other site 1121451010704 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 1121451010705 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121451010706 active site 1121451010707 phosphorylation site [posttranslational modification] 1121451010708 intermolecular recognition site; other site 1121451010709 dimerization interface [polypeptide binding]; other site 1121451010710 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1121451010711 Walker A motif; other site 1121451010712 ATP binding site [chemical binding]; other site 1121451010713 Walker B motif; other site 1121451010714 arginine finger; other site 1121451010715 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1121451010716 Response regulator receiver domain; Region: Response_reg; pfam00072 1121451010717 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121451010718 active site 1121451010719 phosphorylation site [posttranslational modification] 1121451010720 intermolecular recognition site; other site 1121451010721 dimerization interface [polypeptide binding]; other site 1121451010722 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1121451010723 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1121451010724 Walker A motif; other site 1121451010725 ATP binding site [chemical binding]; other site 1121451010726 Walker B motif; other site 1121451010727 arginine finger; other site 1121451010728 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 1121451010729 DNA topoisomerase IV subunit A; Provisional; Region: PRK13979 1121451010730 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 1121451010731 TrkA-C domain; Region: TrkA_C; pfam02080 1121451010732 TrkA-C domain; Region: TrkA_C; pfam02080 1121451010733 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 1121451010734 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 1121451010735 sodium/proton antiporter; Reviewed; Region: nhaB; PRK09547 1121451010736 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1121451010737 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1121451010738 S-adenosylmethionine binding site [chemical binding]; other site 191026010739 Baseplate J-like protein; Region: Baseplate_J; cl01294 191026010740 Phage tail protein (Tail_P2_I); Region: Tail_P2_I; pfam09684 191026010741 AAA domain; Region: AAA_13; pfam13166 191026010742 Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432 191026010743 RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169 191026010744 conjugal transfer relaxosome component TraJ; Provisional; Region: PRK13877 191026010745 Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; pfam09669 191026010746 Fic family protein [Function unknown]; Region: COG3177 191026010747 Fic/DOC family N-terminal; Region: Fic_N; pfam13784 191026010748 Fic/DOC family; Region: Fic; pfam02661 191026010749 integrase; Provisional; Region: PRK09692 191026010750 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 191026010751 active site 191026010752 Int/Topo IB signature motif; other site 191026010753 Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432 191026010754 TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029 191026010755 active site 191026010756 metal binding site [ion binding]; metal-binding site 191026010757 interdomain interaction site; other site 191026010758 AAA domain; Region: AAA_25; pfam13481 191026010759 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 191026010760 Walker A motif; other site 191026010761 ATP binding site [chemical binding]; other site 191026010762 Walker B motif; other site 191026010763 Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; cl17523 191026010764 Predicted transcriptional regulator [Transcription]; Region: COG3905 191026010765 Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016 191026010766 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 191026010767 Integrase core domain; Region: rve_3; pfam13683 191026010768 HTH-like domain; Region: HTH_21; pfam13276 191026010769 Integrase core domain; Region: rve; pfam00665 191026010770 Integrase core domain; Region: rve_3; pfam13683 191026010771 Transposase; Region: HTH_Tnp_1; pfam01527 191026010772 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 191026010773 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 191026010774 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 191026010775 putative active site [active] 191026010776 putative NTP binding site [chemical binding]; other site 191026010777 putative nucleic acid binding site [nucleotide binding]; other site 191026010778 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cd09634 191026010779 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725 191026010780 CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cl17214 191026010781 CRISPR/Cas system-associated protein Cmr5; Region: Cmr5_III-B; cl01317 191026010782 CRISPR system related protein, RAMP superfamily [Defense mechanisms]; Region: COG1336 191026010783 CRISPR-associated protein (Cas_Cmr3); Region: Cas_Cmr3; pfam09700 191026010784 CRISPR/Cas system-associated RAMP superfamily protein Cmr3; Region: Cmr3_III-B; cl12075 191026010785 CRISPR-associated protein Cas10/Cmr2, subtype III-B; Region: cas_TM1794_Cmr2; TIGR02577 191026010786 CRISPR-associated protein; Region: DUF3692; pfam12469 191026010787 CRISPR/Cas system-associated protein Cas10; Region: Cas10_III; cl13853 191026010788 CRISPR/Cas system-associated RAMP superfamily protein Cmr1; Region: Cmr1_III-B; cl17436 191026010789 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 191026010790 Na/Pi-cotransporter; Region: NaPi_cotrn_rel; TIGR00704 191026010791 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 191026010792 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 191026010793 Outer membrane protein (OmpH-like); Region: OmpH; pfam03938 191026010794 Pyruvate kinase [Carbohydrate transport and metabolism]; Region: PykF; COG0469 191026010795 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 191026010796 domain interfaces; other site 191026010797 active site 191026010798 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 191026010799 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 191026010800 dimer interface [polypeptide binding]; other site 191026010801 putative anticodon binding site; other site 191026010802 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 191026010803 motif 1; other site 191026010804 active site 191026010805 motif 2; other site 191026010806 motif 3; other site 191026010807 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 191026010808 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 191026010809 FtsX-like permease family; Region: FtsX; pfam02687 191026010810 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 191026010811 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 191026010812 Walker A/P-loop; other site 191026010813 ATP binding site [chemical binding]; other site 191026010814 Q-loop/lid; other site 191026010815 ABC transporter signature motif; other site 191026010816 Walker B; other site 191026010817 D-loop; other site 191026010818 H-loop/switch region; other site 191026010819 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 191026010820 outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303 191026010821 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 191026010822 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 191026010823 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 191026010824 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 191026010825 Surface antigen; Region: Bac_surface_Ag; pfam01103 191026010826 Outer membrane protein (OmpH-like); Region: OmpH; pfam03938 191026010827 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 191026010828 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 191026010829 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 191026010830 trimer interface [polypeptide binding]; other site 191026010831 active site 191026010832 UDP-GlcNAc binding site [chemical binding]; other site 191026010833 lipid binding site [chemical binding]; lipid-binding site 191026010834 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 191026010835 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 191026010836 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 191026010837 active site 191026010838 Protein of unknown function (DUF1009); Region: DUF1009; pfam06230 191026010839 putative regulatory protein, FmdB family; Region: CxxC_CxxC_SSSS; TIGR02605 191026010840 CGGC domain; Region: CGGC; cl02356 191026010841 MinD superfamily P-loop ATPase containing an inserted ferredoxin domain [Energy production and conversion]; Region: COG1149 191026010842 This protein family's function is unkown. It contains nucleotide binding site. It uses NTP as energy source to transfer electron or ion; Region: Fer4_NifH_child; cd03110 191026010843 P loop nucleotide binding; other site 191026010844 switch II; other site 191026010845 MinD superfamily P-loop ATPase containing an inserted ferredoxin domain [Energy production and conversion]; Region: COG1149 191026010846 This protein family's function is unkown. It contains nucleotide binding site. It uses NTP as energy source to transfer electron or ion; Region: Fer4_NifH_child; cd03110 191026010847 P loop nucleotide binding; other site 191026010848 switch II; other site 191026010849 Protein of unknown function DUF89; Region: DUF89; cl15397 191026010850 AsmA family; Region: AsmA; pfam05170 191026010851 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 191026010852 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 191026010853 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 191026010854 Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322 191026010855 Na binding site [ion binding]; other site 191026010856 probable sodium:solute symporter, VC_2705 subfamily; Region: Na_symport_lg; TIGR03648 191026010857 glutamate dehydrogenase; Provisional; Region: PRK09414 191026010858 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 191026010859 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 191026010860 NAD(P) binding site [chemical binding]; other site 191026010861 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 191026010862 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 191026010863 active site 191026010864 phosphorylation site [posttranslational modification] 191026010865 intermolecular recognition site; other site 191026010866 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 191026010867 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 191026010868 anti sigma factor interaction site; other site 191026010869 regulatory phosphorylation site [posttranslational modification]; other site 191026010870 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 191026010871 anti sigma factor interaction site; other site 191026010872 regulatory phosphorylation site [posttranslational modification]; other site 191026010873 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 191026010874 Protein export membrane protein; Region: SecD_SecF; cl14618 191026010875 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 191026010876 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 191026010877 HlyD family secretion protein; Region: HlyD_3; pfam13437 191026010878 Predicted kinase related to dihydroxyacetone kinase [General function prediction only]; Region: COG1461 191026010879 DAK2 domain; Region: Dak2; pfam02734 191026010880 EDD domain protein, DegV family; Region: DegV; TIGR00762 191026010881 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 191026010882 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 191026010883 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 191026010884 Walker A/P-loop; other site 191026010885 ATP binding site [chemical binding]; other site 191026010886 Q-loop/lid; other site 191026010887 ABC transporter signature motif; other site 191026010888 Walker B; other site 191026010889 D-loop; other site 191026010890 H-loop/switch region; other site 191026010891 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 191026010892 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 191026010893 substrate binding pocket [chemical binding]; other site 191026010894 membrane-bound complex binding site; other site 191026010895 hinge residues; other site 191026010896 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 191026010897 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 191026010898 dimer interface [polypeptide binding]; other site 191026010899 conserved gate region; other site 191026010900 putative PBP binding loops; other site 191026010901 ABC-ATPase subunit interface; other site 191026010902 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 191026010903 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 191026010904 dimer interface [polypeptide binding]; other site 191026010905 conserved gate region; other site 191026010906 putative PBP binding loops; other site 191026010907 ABC-ATPase subunit interface; other site 191026010908 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 191026010909 intersubunit interface [polypeptide binding]; other site 191026010910 active site 191026010911 catalytic residue [active] 191026010912 cobalt-precorrin-8X methylmutase; Validated; Region: cbiC; cl00913 191026010913 Precorrin-8X methylmutase; Region: CbiC; pfam02570 191026010914 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 191026010915 dimerization interface [polypeptide binding]; other site 191026010916 PAS domain S-box; Region: sensory_box; TIGR00229 191026010917 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 191026010918 putative active site [active] 191026010919 heme pocket [chemical binding]; other site 191026010920 PAS domain S-box; Region: sensory_box; TIGR00229 191026010921 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 191026010922 putative active site [active] 191026010923 heme pocket [chemical binding]; other site 191026010924 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 191026010925 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 191026010926 metal binding site [ion binding]; metal-binding site 191026010927 active site 191026010928 I-site; other site 191026010929 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 191026010930 Ferredoxin [Energy production and conversion]; Region: COG1146 191026010931 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 191026010932 2-oxoglutarate ferredoxin oxidoreductase subunit alpha; Validated; Region: PRK08659 191026010933 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 191026010934 dimer interface [polypeptide binding]; other site 191026010935 PYR/PP interface [polypeptide binding]; other site 191026010936 TPP binding site [chemical binding]; other site 191026010937 substrate binding site [chemical binding]; other site 191026010938 2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867 191026010939 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 191026010940 TPP-binding site [chemical binding]; other site 191026010941 2-oxoglutarate ferredoxin oxidoreductase subunit gamma; Validated; Region: PRK08537 191026010942 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546 191026010943 Transcriptional regulator containing GAF, AAA-type ATPase, and DNA binding domains [Transcription / Signal transduction mechanisms]; Region: FhlA; COG3604 191026010944 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 191026010945 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 191026010946 Walker A motif; other site 191026010947 ATP binding site [chemical binding]; other site 191026010948 Walker B motif; other site 191026010949 arginine finger; other site 191026010950 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 191026010951 pyruvate/ketoisovalerate ferredoxin oxidoreductase subunit gamma; Provisional; Region: PRK14029 191026010952 indolepyruvate oxidoreductase subunit beta; Reviewed; Region: PRK06853 191026010953 indolepyruvate ferredoxin oxidoreductase, alpha subunit; Region: IOR_alpha; TIGR03336 191026010954 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 191026010955 dimer interface [polypeptide binding]; other site 191026010956 PYR/PP interface [polypeptide binding]; other site 191026010957 TPP binding site [chemical binding]; other site 191026010958 substrate binding site [chemical binding]; other site 191026010959 Thiamine pyrophosphate (TPP) family, IOR-alpha subfamily, TPP-binding module; composed of proteins similar to indolepyruvate ferredoxin oxidoreductase (IOR) alpha subunit. IOR catalyzes the oxidative decarboxylation of arylpyruvates, such as...; Region: TPP_IOR_alpha; cd02008 191026010960 TPP-binding site; other site 191026010961 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 191026010962 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 191026010963 putative catalytic cysteine [active] 191026010964 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 191026010965 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 191026010966 active site 191026010967 (T/H)XGH motif; other site 191026010968 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 191026010969 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 191026010970 putative active site [active] 191026010971 Domain of unknown function DUF21; Region: DUF21; pfam01595 191026010972 FOG: CBS domain [General function prediction only]; Region: COG0517 191026010973 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 191026010974 CcmE; Region: CcmE; cl00994 191026010975 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: CcmF; COG1138 191026010976 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 191026010977 cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13538 191026010978 Walker A/P-loop; other site 191026010979 ATP binding site [chemical binding]; other site 191026010980 Q-loop/lid; other site 191026010981 ABC transporter signature motif; other site 191026010982 Walker B; other site 191026010983 D-loop; other site 191026010984 H-loop/switch region; other site 191026010985 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 191026010986 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 191026010987 binding surface 191026010988 Tetratricopeptide repeat; Region: TPR_16; pfam13432 191026010989 TPR motif; other site 191026010990 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 191026010991 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 191026010992 dimerization interface [polypeptide binding]; other site 191026010993 ligand binding site [chemical binding]; other site 191026010994 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 191026010995 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 191026010996 TM-ABC transporter signature motif; other site 191026010997 leucine/isoleucine/valine transporter permease subunit; Provisional; Region: livM; PRK11301 191026010998 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 191026010999 TM-ABC transporter signature motif; other site 191026011000 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 191026011001 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 191026011002 Walker A/P-loop; other site 191026011003 ATP binding site [chemical binding]; other site 191026011004 Q-loop/lid; other site 191026011005 ABC transporter signature motif; other site 191026011006 Walker B; other site 191026011007 D-loop; other site 191026011008 H-loop/switch region; other site 191026011009 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 191026011010 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 191026011011 Walker A/P-loop; other site 191026011012 ATP binding site [chemical binding]; other site 191026011013 Q-loop/lid; other site 191026011014 ABC transporter signature motif; other site 191026011015 Walker B; other site 191026011016 D-loop; other site 191026011017 H-loop/switch region; other site 191026011018 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 191026011019 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 191026011020 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 191026011021 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 191026011022 active site 191026011023 GMP synthase; Reviewed; Region: guaA; PRK00074 191026011024 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 191026011025 AMP/PPi binding site [chemical binding]; other site 191026011026 candidate oxyanion hole; other site 191026011027 catalytic triad [active] 191026011028 potential glutamine specificity residues [chemical binding]; other site 191026011029 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 191026011030 ATP Binding subdomain [chemical binding]; other site 191026011031 Ligand Binding sites [chemical binding]; other site 191026011032 Dimerization subdomain; other site 191026011033 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 191026011034 Sec-independent protein translocase protein (TatC); Region: TatC; pfam00902 191026011035 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 191026011036 putative active site pocket [active] 191026011037 4-fold oligomerization interface [polypeptide binding]; other site 191026011038 metal binding residues [ion binding]; metal-binding site 191026011039 3-fold/trimer interface [polypeptide binding]; other site 191026011040 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 191026011041 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 191026011042 catalytic residues [active] 191026011043 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 191026011044 metal-binding site [ion binding] 191026011045 Rubrerythrin [Energy production and conversion]; Region: COG1592 191026011046 Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041 191026011047 binuclear metal center [ion binding]; other site 191026011048 Rubredoxin_like; nonheme iron binding domain containing a [Fe(SCys)4] center. The family includes rubredoxins, a small electron transfer protein, and a slightly smaller modular rubredoxin domain present in rubrerythrin and nigerythrin and detected either...; Region: rubredoxin_like; cl00202 191026011049 iron binding site [ion binding]; other site 191026011050 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 191026011051 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 191026011052 homodimer interface [polypeptide binding]; other site 191026011053 metal binding site [ion binding]; metal-binding site 191026011054 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 191026011055 homodimer interface [polypeptide binding]; other site 191026011056 active site 191026011057 putative chemical substrate binding site [chemical binding]; other site 191026011058 metal binding site [ion binding]; metal-binding site 191026011059 Colicin V production protein; Region: Colicin_V; pfam02674 191026011060 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908 191026011061 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168 191026011062 heme-binding residues [chemical binding]; other site 191026011063 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 191026011064 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 191026011065 molybdopterin cofactor binding site; other site 191026011066 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 191026011067 Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437 191026011068 Polysulphide reductase [Energy production and conversion]; Region: COG5557; cl17901 191026011069 Polysulphide reductase, NrfD; Region: NrfD; pfam03916 191026011070 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 191026011071 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 191026011072 ligand binding site [chemical binding]; other site 191026011073 flexible hinge region; other site 191026011074 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 191026011075 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 191026011076 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 191026011077 Walker A/P-loop; other site 191026011078 ATP binding site [chemical binding]; other site 191026011079 Q-loop/lid; other site 191026011080 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4619 191026011081 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 191026011082 ABC transporter signature motif; other site 191026011083 Walker B; other site 191026011084 D-loop; other site 191026011085 H-loop/switch region; other site 191026011086 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 191026011087 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 191026011088 anti sigma factor interaction site; other site 191026011089 regulatory phosphorylation site [posttranslational modification]; other site 191026011090 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 191026011091 active site residue [active] 191026011092 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 191026011093 Mechanosensitive ion channel; Region: MS_channel; pfam00924 191026011094 Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703 191026011095 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 191026011096 ADP binding site [chemical binding]; other site 191026011097 magnesium binding site [ion binding]; other site 191026011098 putative shikimate binding site; other site 191026011099 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 191026011100 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 191026011101 Tetramer interface [polypeptide binding]; other site 191026011102 active site 191026011103 FMN-binding site [chemical binding]; other site 191026011104 Putative heavy-metal-binding; Region: YbjQ_1; pfam01906 191026011105 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 191026011106 dimerization interface [polypeptide binding]; other site 191026011107 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 191026011108 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 191026011109 dimer interface [polypeptide binding]; other site 191026011110 phosphorylation site [posttranslational modification] 191026011111 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 191026011112 ATP binding site [chemical binding]; other site 191026011113 Mg2+ binding site [ion binding]; other site 191026011114 G-X-G motif; other site 191026011115 Response regulator receiver domain; Region: Response_reg; pfam00072 191026011116 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 191026011117 active site 191026011118 phosphorylation site [posttranslational modification] 191026011119 intermolecular recognition site; other site 191026011120 dimerization interface [polypeptide binding]; other site 191026011121 Response regulator receiver domain; Region: Response_reg; pfam00072 191026011122 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 191026011123 active site 191026011124 phosphorylation site [posttranslational modification] 191026011125 intermolecular recognition site; other site 191026011126 dimerization interface [polypeptide binding]; other site 191026011127 NAD synthetase; Provisional; Region: PRK13981 191026011128 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 191026011129 multimer interface [polypeptide binding]; other site 191026011130 active site 191026011131 catalytic triad [active] 191026011132 protein interface 1 [polypeptide binding]; other site 191026011133 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 191026011134 homodimer interface [polypeptide binding]; other site 191026011135 NAD binding pocket [chemical binding]; other site 191026011136 ATP binding pocket [chemical binding]; other site 191026011137 Mg binding site [ion binding]; other site 191026011138 active-site loop [active] 191026011139 Response regulator receiver domain; Region: Response_reg; pfam00072 191026011140 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 191026011141 active site 191026011142 phosphorylation site [posttranslational modification] 191026011143 intermolecular recognition site; other site 191026011144 dimerization interface [polypeptide binding]; other site 191026011145 HDOD domain; Region: HDOD; pfam08668 191026011146 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 191026011147 Zn2+ binding site [ion binding]; other site 191026011148 Mg2+ binding site [ion binding]; other site 191026011149 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 191026011150 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 191026011151 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 191026011152 active site 191026011153 Protein of unknown function DUF115; Region: MAF_flag10; pfam01973 191026011154 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 191026011155 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 191026011156 dimer interface [polypeptide binding]; other site 191026011157 pyridoxal 5'-phosphate binding site [chemical binding]; other site 191026011158 catalytic residue [active] 191026011159 Cysteinyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: CysS; COG0215 191026011160 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 191026011161 Predicted transmembrane sensor domain [Signal transduction mechanisms]; Region: COG4252 191026011162 CHASE2 domain; Region: CHASE2; pfam05226 191026011163 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 191026011164 cyclase homology domain; Region: CHD; cd07302 191026011165 nucleotidyl binding site; other site 191026011166 metal binding site [ion binding]; metal-binding site 191026011167 dimer interface [polypeptide binding]; other site 191026011168 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 191026011169 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 191026011170 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 191026011171 Walker A/P-loop; other site 191026011172 ATP binding site [chemical binding]; other site 191026011173 Q-loop/lid; other site 191026011174 ABC transporter signature motif; other site 191026011175 Walker B; other site 191026011176 D-loop; other site 191026011177 H-loop/switch region; other site 191026011178 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 191026011179 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 191026011180 HlyD family secretion protein; Region: HlyD_3; pfam13437 191026011181 TPR repeat; Region: TPR_11; pfam13414 191026011182 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 191026011183 TPR motif; other site 191026011184 binding surface 191026011185 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 191026011186 TPR repeat; Region: TPR_11; pfam13414 191026011187 binding surface 191026011188 TPR motif; other site 191026011189 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 191026011190 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 191026011191 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 191026011192 Response regulator receiver domain; Region: Response_reg; pfam00072 191026011193 active site 191026011194 phosphorylation site [posttranslational modification] 191026011195 intermolecular recognition site; other site 191026011196 dimerization interface [polypeptide binding]; other site 191026011197 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 191026011198 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 191026011199 ligand binding site [chemical binding]; other site 191026011200 flexible hinge region; other site 191026011201 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 191026011202 putative switch regulator; other site 191026011203 non-specific DNA interactions [nucleotide binding]; other site 191026011204 DNA binding site [nucleotide binding] 191026011205 sequence specific DNA binding site [nucleotide binding]; other site 191026011206 putative cAMP binding site [chemical binding]; other site 191026011207 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 191026011208 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 191026011209 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 191026011210 4Fe-4S single cluster domain; Region: Fer4_15; pfam13459 191026011211 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 191026011212 hybrid cluster protein; Provisional; Region: PRK05290 191026011213 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 191026011214 ACS interaction site; other site 191026011215 Hybrid cluster protein (HCP), formerly known as prismane, is thought to play a role in nitrogen metabolism but its specific function is unknown. HCP has three structural domains, an N-terminal alpha-helical domain, and two similar domains comprising a...; Region: HCP; cd01914 191026011216 hybrid metal cluster; other site 191026011217 purine nucleoside phosphorylase; Provisional; Region: PRK08202 191026011218 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 191026011219 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 191026011220 Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360 191026011221 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 191026011222 ligand binding site [chemical binding]; other site 191026011223 PilZ domain; Region: PilZ; pfam07238 191026011224 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 191026011225 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 191026011226 ATP-grasp domain; Region: ATP-grasp_4; cl17255 191026011227 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 191026011228 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; pfam03255 191026011229 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 191026011230 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 191026011231 urea carboxylase; Region: urea_carbox; TIGR02712 191026011232 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 191026011233 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 191026011234 dimer interface [polypeptide binding]; other site 191026011235 ssDNA binding site [nucleotide binding]; other site 191026011236 tetramer (dimer of dimers) interface [polypeptide binding]; other site 191026011237 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 191026011238 Nitrogen regulatory protein P-II; Region: P-II; smart00938 191026011239 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 191026011240 TPR repeat; Region: TPR_11; pfam13414 191026011241 PilZ domain; Region: PilZ; pfam07238 191026011242 PilZ domain; Region: PilZ; pfam07238 191026011243 Bacterial SNF2 helicase associated; Region: SNF2_assoc; pfam08455 191026011244 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 191026011245 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 191026011246 ATP binding site [chemical binding]; other site 191026011247 putative Mg++ binding site [ion binding]; other site 191026011248 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 191026011249 nucleotide binding region [chemical binding]; other site 191026011250 ATP-binding site [chemical binding]; other site 191026011251 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 191026011252 The substrate-binding component of the oligopeptide-binding protein, AppA, from Bacillus subtilis contains the type 2 periplasmic-binding fold; Region: PBP2_AppA_like; cd08514 191026011253 peptide binding site [polypeptide binding]; other site 191026011254 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 191026011255 HD domain; Region: HD_4; pfam13328 191026011256 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 191026011257 synthetase active site [active] 191026011258 NTP binding site [chemical binding]; other site 191026011259 metal binding site [ion binding]; metal-binding site 191026011260 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 191026011261 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 191026011262 Isochorismatase family; Region: Isochorismatase; pfam00857 191026011263 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 191026011264 catalytic triad [active] 191026011265 conserved cis-peptide bond; other site 191026011266 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 191026011267 Domain of unknown function (DUF1956); Region: DUF1956; pfam09209 191026011268 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 191026011269 HlyD family secretion protein; Region: HlyD_3; pfam13437 191026011270 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 191026011271 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 191026011272 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 191026011273 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 191026011274 Ornithine/acetylornithine aminotransferase [Amino acid transport and metabolism]; Region: ArgD; COG4992 191026011275 inhibitor-cofactor binding pocket; inhibition site 191026011276 pyridoxal 5'-phosphate binding site [chemical binding]; other site 191026011277 catalytic residue [active] 191026011278 hopanoid biosynthesis associated RND transporter like protein HpnN; Region: HpnN; TIGR03480 191026011279 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 191026011280 Tetratricopeptide repeat; Region: TPR_16; pfam13432 191026011281 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 191026011282 TPR motif; other site 191026011283 hopanoid biosynthesis associated radical SAM protein HpnH; Region: HpnH; TIGR03470 191026011284 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 191026011285 FeS/SAM binding site; other site 191026011286 Domain of unknown function (DUF3463); Region: DUF3463; pfam11946 191026011287 hopanoid-associated phosphorylase; Region: HpnG; TIGR03468 191026011288 AAA domain; Region: AAA_32; pfam13654 191026011289 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 191026011290 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 191026011291 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 191026011292 putative dimer interface [polypeptide binding]; other site 191026011293 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 191026011294 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 191026011295 substrate binding pocket [chemical binding]; other site 191026011296 membrane-bound complex binding site; other site 191026011297 hinge residues; other site 191026011298 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 191026011299 dimer interface [polypeptide binding]; other site 191026011300 conserved gate region; other site 191026011301 putative PBP binding loops; other site 191026011302 ABC-ATPase subunit interface; other site 191026011303 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 191026011304 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 191026011305 Walker A/P-loop; other site 191026011306 ATP binding site [chemical binding]; other site 191026011307 Q-loop/lid; other site 191026011308 ABC transporter signature motif; other site 191026011309 Walker B; other site 191026011310 D-loop; other site 191026011311 H-loop/switch region; other site 191026011312 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 191026011313 Predicted membrane protein [Function unknown]; Region: COG1289 191026011314 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 191026011315 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 191026011316 Domain of unknown function DUF20; Region: UPF0118; pfam01594 191026011317 GtrA-like protein; Region: GtrA; pfam04138 191026011318 Glucosyl transferase GtrII; Region: Glucos_trans_II; pfam14264 191026011319 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 191026011320 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 191026011321 Ligand binding site; other site 191026011322 Putative Catalytic site; other site 191026011323 DXD motif; other site 191026011324 Bacteriophage CI repressor helix-turn-helix domain; Region: Phage_CI_repr; pfam07022 191026011325 Mu DNA-binding domain; Region: HTH_Tnp_Mu_1; pfam02316 191026011326 Integrase core domain; Region: rve; pfam00665 191026011327 Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299 191026011328 AAA domain; Region: AAA_22; pfam13401 191026011329 Protein of unknown function (DUF1018); Region: DUF1018; pfam06252 191026011330 Mor transcription activator family; Region: Mor; cl02360 191026011331 Protein of unknown function (DUF2730); Region: DUF2730; pfam10805 191026011332 Phage virion morphogenesis family; Region: Phage_tail_S; cl02089 191026011333 Phage-related baseplate assembly protein; Region: Phage_base_V; cl17812 191026011334 Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; cl01733 191026011335 Gene 25-like lysozyme; Region: GPW_gp25; cl01403 191026011336 Baseplate J-like protein; Region: Baseplate_J; cl01294 191026011337 Phage tail protein (Tail_P2_I); Region: Tail_P2_I; pfam09684 191026011338 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 191026011339 major tail sheath protein; Provisional; Region: FI; PHA02560 191026011340 Phage tail tube protein FII; Region: Phage_tube; pfam04985 191026011341 Mu-like prophage FluMu protein gp41; Region: FluMu_gp41; pfam10109 191026011342 Phage P2 GpE; Region: Phage_P2_GpE; pfam06528 191026011343 phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760 191026011344 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 191026011345 Na binding site [ion binding]; other site 191026011346 Phage P2 GpU; Region: Phage_P2_GpU; pfam06995 191026011347 Phage Tail Protein X; Region: Phage_tail_X; cl02088 191026011348 Phage late control gene D protein (GPD); Region: Phage_GPD; cl15796 191026011349 Integrase core domain; Region: rve; pfam00665 191026011350 Transposase; Region: HTH_Tnp_1; pfam01527 191026011351 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 191026011352 Methyltransferase domain; Region: Methyltransf_23; pfam13489 191026011353 Glycosyltransferase sugar-binding region containing DXD motif; Region: Gly_transf_sug; pfam04488 191026011354 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 191026011355 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 191026011356 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 191026011357 NAD(P) binding site [chemical binding]; other site 191026011358 active site 191026011359 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 191026011360 This family is most closely related to the GT1 family of glycosyltransferases. ExpE7 in Sinorhizobium meliloti has been shown to be involved in the biosynthesis of galactoglucans (exopolysaccharide II); Region: GT1_ExpE7_like; cd03823 191026011361 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535 191026011362 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 191026011363 FeS/SAM binding site; other site 191026011364 Domain of unknown function (DUF4008); Region: DUF4008; pfam13186 191026011365 C-20 methyltransferase BchU; Region: C20_methyl_CrtF; TIGR02716 191026011366 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 191026011367 S-adenosylmethionine binding site [chemical binding]; other site 191026011368 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 191026011369 catalytic core [active] 191026011370 WYL domain; Region: WYL; pfam13280 191026011371 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 191026011372 Divergent AAA domain; Region: AAA_4; pfam04326 191026011373 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 191026011374 Transposase; Region: HTH_Tnp_1; pfam01527 191026011375 HTH-like domain; Region: HTH_21; pfam13276 191026011376 Integrase core domain; Region: rve; pfam00665 191026011377 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 191026011378 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 191026011379 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 191026011380 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 191026011381 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 191026011382 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 191026011383 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 191026011384 Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072 191026011385 BsuBI/PstI restriction endonuclease C-terminus; Region: BsuBI_PstI_RE; pfam06616 191026011386 type II restriction m6 adenine DNA methyltransferase, Alw26I/Eco31I/Esp3I family; Region: met_A_Alw26; TIGR02987 191026011387 Methyltransferase domain; Region: Methyltransf_26; pfam13659 191026011388 Helix-turn-helix domain; Region: HTH_17; pfam12728 191026011389 Transposase; Region: HTH_Tnp_1; pfam01527 191026011390 Site-specific recombinase XerC [DNA replication, recombination, and repair]; Region: XerC; COG4973 191026011391 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 191026011392 active site 191026011393 catalytic residues [active] 191026011394 DNA binding site [nucleotide binding] 191026011395 Int/Topo IB signature motif; other site 191026011396 Helix-turn-helix domain; Region: HTH_17; pfam12728 191026011397 The accessory protein CooC, which contains a nucleotide-binding domain (P-loop) near the N-terminus, participates in the maturation of the nickel center of carbon monoxide dehydrogenase (CODH). CODH from Rhodospirillum rubrum catalyzes the reversible...; Region: CooC; cd02034 191026011398 P-loop; other site 191026011399 P-type conjugative transfer ATPase TrbB; Region: TrbB_P; TIGR02782 191026011400 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 191026011401 ATP binding site [chemical binding]; other site 191026011402 Walker A motif; other site 191026011403 hexamer interface [polypeptide binding]; other site 191026011404 Walker B motif; other site 191026011405 TrbC/VIRB2 family; Region: TrbC; pfam04956 191026011406 P-type conjugative transfer ATPase TrbB; Region: TrbB_P; TIGR02782 191026011407 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 191026011408 Walker A motif; other site 191026011409 ATP binding site [chemical binding]; other site 191026011410 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 191026011411 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 191026011412 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 191026011413 catalytic residue [active] 191026011414 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 191026011415 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 191026011416 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 191026011417 S-adenosylmethionine binding site [chemical binding]; other site 191026011418 TIGR01210 family protein; Region: TIGR01210 191026011419 TIGR01210 family protein; Region: TIGR01210 191026011420 ATP-grasp domain; Region: ATP-grasp_4; cl17255 191026011421 TIGR01210 family protein; Region: TIGR01210 191026011422 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 191026011423 FeS/SAM binding site; other site 191026011424 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 191026011425 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 191026011426 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 191026011427 AAA domain; Region: AAA_21; pfam13304 191026011428 Walker A/P-loop; other site 191026011429 ATP binding site [chemical binding]; other site 191026011430 Q-loop/lid; other site 191026011431 ABC transporter signature motif; other site 191026011432 Walker B; other site 191026011433 D-loop; other site 191026011434 H-loop/switch region; other site 191026011435 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 191026011436 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 191026011437 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 191026011438 catalytic residue [active] 191026011439 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 191026011440 Radical SAM superfamily; Region: Radical_SAM; pfam04055 191026011441 FeS/SAM binding site; other site 191026011442 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 191026011443 active site 191026011444 A predicted NlpC/p60-like peptidase; Region: BtrH; pfam14399 191026011445 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 191026011446 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 191026011447 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 191026011448 acyl-activating enzyme (AAE) consensus motif; other site 191026011449 acyl-activating enzyme (AAE) consensus motif; other site 191026011450 AMP binding site [chemical binding]; other site 191026011451 active site 191026011452 CoA binding site [chemical binding]; other site 191026011453 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 191026011454 NAD synthetase; Provisional; Region: PRK13980 191026011455 Ligand Binding Site [chemical binding]; other site 191026011456 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 191026011457 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 191026011458 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 191026011459 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 191026011460 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 191026011461 ATP binding site [chemical binding]; other site 191026011462 putative Mg++ binding site [ion binding]; other site 191026011463 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 191026011464 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 191026011465 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 191026011466 Protein of unknown function (Hypoth_ymh); Region: Hypoth_Ymh; pfam09509 191026011467 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 191026011468 HsdM N-terminal domain; Region: HsdM_N; pfam12161 191026011469 Methyltransferase domain; Region: Methyltransf_26; pfam13659 191026011470 DNA binding domain, excisionase family; Region: excise; TIGR01764 191026011471 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 191026011472 putative active site pocket [active] 191026011473 dimerization interface [polypeptide binding]; other site 191026011474 putative catalytic residue [active] 191026011475 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cd00352 191026011476 active site 191026011477 Glutamine amidotransferase domain; Region: GATase_6; pfam13522 191026011478 Putative amidoligase enzyme; Region: Amidoligase_2; pfam12224 191026011479 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 191026011480 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 191026011481 catalytic residues [active] 191026011482 catalytic nucleophile [active] 191026011483 Presynaptic Site I dimer interface [polypeptide binding]; other site 191026011484 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 191026011485 Synaptic Flat tetramer interface [polypeptide binding]; other site 191026011486 Synaptic Site I dimer interface [polypeptide binding]; other site 191026011487 DNA binding site [nucleotide binding] 191026011488 Recombinase; Region: Recombinase; pfam07508 191026011489 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 191026011490 Protein of unknown function (DUF2924); Region: DUF2924; pfam11149 191026011491 Protein of unknown function (DUF2924); Region: DUF2924; pfam11149 191026011492 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 191026011493 LexA repressor; Validated; Region: PRK00215 191026011494 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 191026011495 Catalytic site [active] 191026011496 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 191026011497 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 191026011498 dimer interface [polypeptide binding]; other site 191026011499 conserved gate region; other site 191026011500 ABC-ATPase subunit interface; other site 191026011501 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 191026011502 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 191026011503 dimer interface [polypeptide binding]; other site 191026011504 conserved gate region; other site 191026011505 putative PBP binding loops; other site 191026011506 ABC-ATPase subunit interface; other site 191026011507 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 191026011508 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 191026011509 Walker A/P-loop; other site 191026011510 ATP binding site [chemical binding]; other site 191026011511 Q-loop/lid; other site 191026011512 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 191026011513 ABC transporter signature motif; other site 191026011514 Walker B; other site 191026011515 D-loop; other site 191026011516 H-loop/switch region; other site 191026011517 NAD(P)H:flavin oxidoreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes; Region: NADPH_oxidoreductase_1; cd02150 191026011518 putative FMN binding site [chemical binding]; other site 191026011519 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 191026011520 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 191026011521 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 191026011522 Response regulator receiver domain; Region: Response_reg; pfam00072 191026011523 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 191026011524 active site 191026011525 phosphorylation site [posttranslational modification] 191026011526 intermolecular recognition site; other site 191026011527 dimerization interface [polypeptide binding]; other site 191026011528 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 191026011529 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 191026011530 active site 191026011531 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 191026011532 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535 191026011533 FeS/SAM binding site; other site 191026011534 Methyltransferase domain; Region: Methyltransf_31; pfam13847 191026011535 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 191026011536 S-adenosylmethionine binding site [chemical binding]; other site 191026011537 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 191026011538 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 191026011539 GTPase CgtA; Reviewed; Region: obgE; PRK12299 191026011540 GTP1/OBG; Region: GTP1_OBG; pfam01018 191026011541 Obg GTPase; Region: Obg; cd01898 191026011542 G1 box; other site 191026011543 GTP/Mg2+ binding site [chemical binding]; other site 191026011544 Switch I region; other site 191026011545 G2 box; other site 191026011546 G3 box; other site 191026011547 Switch II region; other site 191026011548 G4 box; other site 191026011549 G5 box; other site 191026011550 gamma-glutamyl kinase; Provisional; Region: PRK05429 191026011551 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 191026011552 nucleotide binding site [chemical binding]; other site 191026011553 homotetrameric interface [polypeptide binding]; other site 191026011554 putative phosphate binding site [ion binding]; other site 191026011555 putative allosteric binding site; other site 191026011556 PUA domain; Region: PUA; pfam01472 191026011557 CRISPR/Cas system-associated protein Cas10; Region: Cas10_III; cl13853 191026011558 Ion channel; Region: Ion_trans_2; pfam07885 191026011559 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 191026011560 Major Facilitator Superfamily; Region: MFS_1; pfam07690 191026011561 putative substrate translocation pore; other site 191026011562 PilZ domain; Region: PilZ; pfam07238 191026011563 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 191026011564 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 191026011565 GPR1/FUN34/yaaH family; Region: Grp1_Fun34_YaaH; cl00685 191026011566 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 191026011567 homohexameric interface [polypeptide binding]; other site 191026011568 feedback inhibition sensing region; other site 191026011569 nucleotide binding site [chemical binding]; other site 191026011570 N-acetyl-L-glutamate binding site [chemical binding]; other site 191026011571 putative molybdopterin-guanine dinucleotide biosynthesis protein MobB/FeS domain-containing protein protein; Provisional; Region: PRK14494 191026011572 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 191026011573 Putative Fe-S cluster; Region: FeS; cl17515 191026011574 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 191026011575 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 191026011576 dimer interface [polypeptide binding]; other site 191026011577 putative functional site; other site 191026011578 putative MPT binding site; other site 191026011579 putative molybdopterin biosynthesis protein MoeA/LysR substrate binding-domain-containing protein; Provisional; Region: PRK14498 191026011580 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 191026011581 dimer interface [polypeptide binding]; other site 191026011582 putative functional site; other site 191026011583 putative MPT binding site; other site 191026011584 PBP superfamily domain; Region: PBP_like; pfam12727 191026011585 formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583 191026011586 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 191026011587 octaheme c-type cytochrome, tetrathionate reductase family; Region: octaheme_Shew; TIGR04315 191026011588 Cytochrome c bacterial; Region: Cytochrome_cB; pfam11783 191026011589 hydrogenase 2 protein HybA; Provisional; Region: PRK10882 191026011590 TAT (twin-arginine translocation) pathway signal sequence; Region: TAT_signal; pfam10518 191026011591 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 191026011592 dimer interface [polypeptide binding]; other site 191026011593 Citrate synthase; Region: Citrate_synt; pfam00285 191026011594 active site 191026011595 citrylCoA binding site [chemical binding]; other site 191026011596 NADH binding [chemical binding]; other site 191026011597 cationic pore residues; other site 191026011598 oxalacetate/citrate binding site [chemical binding]; other site 191026011599 coenzyme A binding site [chemical binding]; other site 191026011600 catalytic triad [active] 191026011601 glycerol kinase; Provisional; Region: glpK; PRK00047 191026011602 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 191026011603 N- and C-terminal domain interface [polypeptide binding]; other site 191026011604 active site 191026011605 MgATP binding site [chemical binding]; other site 191026011606 catalytic site [active] 191026011607 metal binding site [ion binding]; metal-binding site 191026011608 glycerol binding site [chemical binding]; other site 191026011609 homotetramer interface [polypeptide binding]; other site 191026011610 homodimer interface [polypeptide binding]; other site 191026011611 FBP binding site [chemical binding]; other site 191026011612 protein IIAGlc interface [polypeptide binding]; other site 191026011613 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 191026011614 amphipathic channel; other site 191026011615 Asn-Pro-Ala signature motifs; other site 191026011616 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 191026011617 DNA-binding transcriptional repressor GlpR; Provisional; Region: PRK10906 191026011618 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 191026011619 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 191026011620 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 191026011621 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 191026011622 ATP binding site [chemical binding]; other site 191026011623 Mg++ binding site [ion binding]; other site 191026011624 motif III; other site 191026011625 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 191026011626 nucleotide binding region [chemical binding]; other site 191026011627 ATP-binding site [chemical binding]; other site 191026011628 RNA recognition motif in the DbpA subfamily of prokaryotic DEAD-box rRNA helicases; Region: RRM_DbpA; cd12252 191026011629 RNA binding site [nucleotide binding]; other site 191026011630 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 191026011631 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 191026011632 decaheme c-type cytochrome, DmsE family; Region: decahem_SO; TIGR03508 191026011633 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 191026011634 FAD binding site [chemical binding]; other site 191026011635 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 191026011636 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 191026011637 THF binding site; other site 191026011638 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 191026011639 substrate binding site [chemical binding]; other site 191026011640 THF binding site; other site 191026011641 zinc-binding site [ion binding]; other site 191026011642 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 191026011643 cystathionine beta-lyase; Provisional; Region: PRK05967 191026011644 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 191026011645 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 191026011646 catalytic residue [active] 191026011647 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 191026011648 active site 191026011649 dimer interface [polypeptide binding]; other site 191026011650 metal binding site [ion binding]; metal-binding site 191026011651 3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase [Cell envelope biogenesis, outer membrane]; Region: KdsA; cl17225 191026011652 Chorismate mutase type II; Region: CM_2; smart00830 191026011653 flavodoxin, short chain; Region: flav_short; TIGR01753 191026011654 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 191026011655 putative binding surface; other site 191026011656 active site 191026011657 ABC transporter ATPase component; Reviewed; Region: PRK11147 191026011658 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 191026011659 Walker A/P-loop; other site 191026011660 ATP binding site [chemical binding]; other site 191026011661 ABC transporter signature motif; other site 191026011662 Walker B; other site 191026011663 D-loop; other site 191026011664 H-loop/switch region; other site 191026011665 ABC transporter; Region: ABC_tran_2; pfam12848 191026011666 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 191026011667 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 191026011668 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 191026011669 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 191026011670 TrkA-N domain; Region: TrkA_N; pfam02254 191026011671 TrkA-C domain; Region: TrkA_C; pfam02080 191026011672 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 191026011673 binding surface 191026011674 Tetratricopeptide repeat; Region: TPR_16; pfam13432 191026011675 TPR motif; other site 191026011676 Tetratricopeptide repeat; Region: TPR_12; pfam13424 191026011677 TPR repeat; Region: TPR_11; pfam13414 191026011678 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 191026011679 TPR motif; other site 191026011680 Glutamine cyclotransferase [Posttranslational modification, protein turnover, chaperones]; Region: COG3823 191026011681 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 191026011682 Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) [Lipid metabolism]; Region: COG1924 191026011683 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 191026011684 CoA enzyme activase uncharacterized domain (DUF2229); Region: DUF2229; cl17855 191026011685 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3581 191026011686 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 191026011687 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 191026011688 FecR protein; Region: FecR; pfam04773 191026011689 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 191026011690 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 191026011691 FecR protein; Region: FecR; pfam04773 191026011692 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 191026011693 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 191026011694 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 191026011695 Cobyrinic acid a,c-diamide synthase [Coenzyme metabolism]; Region: CobB; COG1797 191026011696 Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132 191026011697 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 191026011698 catalytic triad [active] 191026011699 Dissimilatory sulfite reductase D (DsrD); Region: DsrD; pfam08679 191026011700 sulfite reductase, dissimilatory-type beta subunit; Region: dsrB; TIGR02066 191026011701 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 191026011702 sulfite reductase, dissimilatory-type alpha subunit; Region: dsrA; TIGR02064 191026011703 Flagellin N-methylase; Region: FliB; pfam03692 191026011704 Uncharacterized conserved protein [Function unknown]; Region: COG1683 191026011705 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 191026011706 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 191026011707 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 191026011708 Na+-transporting methylmalonyl-CoA/oxaloacetate decarboxylase, beta subunit [Energy production and conversion]; Region: OadB; COG1883 191026011709 Oxaloacetate decarboxylase, gamma chain; Region: OAD_gamma; cl01458 191026011710 Pyruvate/oxaloacetate carboxyltransferase [Energy production and conversion]; Region: COG5016 191026011711 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 191026011712 active site 191026011713 catalytic residues [active] 191026011714 metal binding site [ion binding]; metal-binding site 191026011715 homodimer binding site [polypeptide binding]; other site 191026011716 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 191026011717 carboxyltransferase (CT) interaction site; other site 191026011718 biotinylation site [posttranslational modification]; other site 191026011719 cobalt transport protein CbiM; Validated; Region: PRK06265 191026011720 Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891 191026011721 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_7; cd13133 191026011722 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 191026011723 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 191026011724 IHF dimer interface [polypeptide binding]; other site 191026011725 IHF - DNA interface [nucleotide binding]; other site 191026011726 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 191026011727 oligomerisation interface [polypeptide binding]; other site 191026011728 mobile loop; other site 191026011729 roof hairpin; other site 191026011730 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 191026011731 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 191026011732 ring oligomerisation interface [polypeptide binding]; other site 191026011733 ATP/Mg binding site [chemical binding]; other site 191026011734 stacking interactions; other site 191026011735 hinge regions; other site 191026011736 PHP domain; Region: PHP; pfam02811 191026011737 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase; Region: PHP_HisPPase; cd07432 191026011738 active site 191026011739 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 191026011740 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 191026011741 Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; cl00789 191026011742 Phosphoribosylformylglycinamidine (FGAM) synthase, synthetase domain [Nucleotide transport and metabolism]; Region: PurL; COG0046 191026011743 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 191026011744 dimerization interface [polypeptide binding]; other site 191026011745 ATP binding site [chemical binding]; other site 191026011746 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 191026011747 dimerization interface [polypeptide binding]; other site 191026011748 ATP binding site [chemical binding]; other site 191026011749 HDOD domain; Region: HDOD; pfam08668 191026011750 PAS domain S-box; Region: sensory_box; TIGR00229 191026011751 PAS domain; Region: PAS; smart00091 191026011752 putative active site [active] 191026011753 heme pocket [chemical binding]; other site 191026011754 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 191026011755 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 191026011756 metal binding site [ion binding]; metal-binding site 191026011757 active site 191026011758 I-site; other site 191026011759 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 191026011760 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 191026011761 substrate binding pocket [chemical binding]; other site 191026011762 chain length determination region; other site 191026011763 substrate-Mg2+ binding site; other site 191026011764 catalytic residues [active] 191026011765 aspartate-rich region 1; other site 191026011766 active site lid residues [active] 191026011767 aspartate-rich region 2; other site 191026011768 futalosine nucleosidase; Region: fut_nucase; TIGR03664 191026011769 Vi polysaccharide biosynthesis protein TviB; Provisional; Region: PRK15182 191026011770 TrkA-N domain; Region: TrkA_N; pfam02254 191026011771 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 191026011772 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 191026011773 Uncharacterized protein conserved in bacteria (DUF2065); Region: DUF2065; pfam09838 191026011774 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 191026011775 ubiquinone/menaquinone biosynthesis methyltransferase; Reviewed; Region: ubiE; PRK00216 191026011776 S-adenosylmethionine binding site [chemical binding]; other site 191026011777 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168 191026011778 heme-binding residues [chemical binding]; other site 191026011779 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 191026011780 active site 191026011781 SAM binding site [chemical binding]; other site 191026011782 homodimer interface [polypeptide binding]; other site 191026011783 cobalamin biosynthesis protein CbiG; Validated; Region: PRK05788 191026011784 Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760 191026011785 Cobalamin biosynthesis central region; Region: CbiG_mid; pfam11761 191026011786 Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890 191026011787 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 191026011788 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 191026011789 inhibitor-cofactor binding pocket; inhibition site 191026011790 pyridoxal 5'-phosphate binding site [chemical binding]; other site 191026011791 catalytic residue [active] 191026011792 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 191026011793 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 191026011794 cytochrome c-type protein NapC; Provisional; Region: PRK10617; cl17554 191026011795 NapC/NirT cytochrome c family, N-terminal region; Region: Cytochrom_NNT; pfam03264 191026011796 Seven times multi-haem cytochrome CxxCH; Region: Multi-haem_cyto; pfam13447 191026011797 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 191026011798 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 191026011799 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 191026011800 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 191026011801 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 191026011802 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 191026011803 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 191026011804 active site 191026011805 phosphorylation site [posttranslational modification] 191026011806 intermolecular recognition site; other site 191026011807 dimerization interface [polypeptide binding]; other site 191026011808 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06710 191026011809 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 191026011810 acyl-activating enzyme (AAE) consensus motif; other site 191026011811 putative AMP binding site [chemical binding]; other site 191026011812 putative active site [active] 191026011813 putative CoA binding site [chemical binding]; other site 191026011814 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 191026011815 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 191026011816 dimer interface [polypeptide binding]; other site 191026011817 putative CheW interface [polypeptide binding]; other site 191026011818 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 191026011819 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 191026011820 TPP-binding site; other site 191026011821 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 191026011822 PYR/PP interface [polypeptide binding]; other site 191026011823 dimer interface [polypeptide binding]; other site 191026011824 TPP binding site [chemical binding]; other site 191026011825 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 191026011826 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 191026011827 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 191026011828 substrate binding pocket [chemical binding]; other site 191026011829 chain length determination region; other site 191026011830 substrate-Mg2+ binding site; other site 191026011831 catalytic residues [active] 191026011832 aspartate-rich region 1; other site 191026011833 active site lid residues [active] 191026011834 aspartate-rich region 2; other site 191026011835 Exonuclease VII small subunit; Region: Exonuc_VII_S; cl00750 191026011836 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 191026011837 Peptidase family M23; Region: Peptidase_M23; pfam01551 191026011838 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 191026011839 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 191026011840 generic binding surface II; other site 191026011841 generic binding surface I; other site 191026011842 prolyl-tRNA synthetase; Provisional; Region: PRK09194 191026011843 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 191026011844 dimer interface [polypeptide binding]; other site 191026011845 motif 1; other site 191026011846 active site 191026011847 motif 2; other site 191026011848 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 191026011849 putative deacylase active site [active] 191026011850 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 191026011851 active site 191026011852 motif 3; other site 191026011853 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 191026011854 anticodon binding site; other site 191026011855 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 191026011856 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 191026011857 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 191026011858 Uracil-DNA glycosylases (UDG) and related enzymes; Region: UDG_like; cl00483 191026011859 ligand binding site [chemical binding]; other site 191026011860 active site 191026011861 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 191026011862 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 191026011863 Active Sites [active] 191026011864 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 191026011865 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 191026011866 dimer interface [polypeptide binding]; other site 191026011867 PYR/PP interface [polypeptide binding]; other site 191026011868 TPP binding site [chemical binding]; other site 191026011869 substrate binding site [chemical binding]; other site 191026011870 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 191026011871 Domain of unknown function; Region: EKR; pfam10371 191026011872 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 191026011873 Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377 191026011874 TPP-binding site [chemical binding]; other site 191026011875 dimer interface [polypeptide binding]; other site 191026011876 phosphate acetyltransferase; Reviewed; Region: PRK05632 191026011877 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 191026011878 DRTGG domain; Region: DRTGG; pfam07085 191026011879 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 191026011880 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 191026011881 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 191026011882 transmembrane helices; other site 191026011883 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 191026011884 Malic enzyme, N-terminal domain; Region: malic; pfam00390 191026011885 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 191026011886 putative NAD(P) binding site [chemical binding]; other site 191026011887 Fumarase C-terminus; Region: Fumerase_C; cl00795 191026011888 fumarate hydratase; Provisional; Region: PRK06246 191026011889 fumarate reductase iron-sulfur subunit; Provisional; Region: frdB; PRK13552 191026011890 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 191026011891 fumarate reductase flavoprotein subunit; Provisional; Region: PRK08626 191026011892 L-aspartate oxidase; Provisional; Region: PRK06175 191026011893 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 191026011894 Quinol:fumarate reductase (QFR) Type B subfamily, transmembrane subunit; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinone...; Region: QFR_TypeB_TM; cd00581 191026011895 Iron-sulfur protein interface; other site 191026011896 proximal heme binding site [chemical binding]; other site 191026011897 distal heme binding site [chemical binding]; other site 191026011898 dimer interface [polypeptide binding]; other site 191026011899 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 191026011900 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 191026011901 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 191026011902 Major Facilitator Superfamily; Region: MFS_1; pfam07690 191026011903 putative substrate translocation pore; other site 191026011904 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 191026011905 ApbE family; Region: ApbE; pfam02424 191026011906 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 191026011907 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 191026011908 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 191026011909 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 191026011910 putative active site [active] 191026011911 heme pocket [chemical binding]; other site 191026011912 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 191026011913 dimer interface [polypeptide binding]; other site 191026011914 phosphorylation site [posttranslational modification] 191026011915 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 191026011916 ATP binding site [chemical binding]; other site 191026011917 Mg2+ binding site [ion binding]; other site 191026011918 G-X-G motif; other site 191026011919 Bacterial Ig-like domain; Region: Big_5; pfam13205 191026011920 Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373 191026011921 MG2 domain; Region: A2M_N; pfam01835 191026011922 Alpha-2-macroglobulin family; Region: A2M; pfam00207 191026011923 Proteins similar to alpha2-macroglobulin (alpha (2)-M). Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of...; Region: A2M_like; cd02891 191026011924 surface patch; other site 191026011925 thioester region; other site 191026011926 penicillin-binding protein 1C; Region: PBP_1c; TIGR02073 191026011927 Transglycosylase; Region: Transgly; pfam00912 191026011928 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 191026011929 Penicillin-Binding Protein C-terminus Family; Region: BiPBP_C; pfam06832 191026011930 Immunoglobulin domain; Region: Ig; cl11960 191026011931 benzoyl-CoA reductase, subunit C; Region: benz_CoA_red_C; TIGR02263 191026011932 2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050 191026011933 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 191026011934 30S ribosomal protein S1; Provisional; Region: rpsA; PRK13806 191026011935 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 191026011936 RNA binding site [nucleotide binding]; other site 191026011937 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 191026011938 RNA binding site [nucleotide binding]; other site 191026011939 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 191026011940 RNA binding site [nucleotide binding]; other site 191026011941 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 191026011942 RNA binding site [nucleotide binding]; other site 191026011943 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cd00164 191026011944 RNA binding site [nucleotide binding]; other site 191026011945 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 191026011946 FxsA cytoplasmic membrane protein; Region: FxsA; pfam04186 191026011947 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 191026011948 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 191026011949 Sporulation related domain; Region: SPOR; pfam05036 191026011950 Predicted RNA-binding protein, contains TRAM domain [General function prediction only]; Region: COG3269 191026011951 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 191026011952 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 191026011953 S-adenosylmethionine binding site [chemical binding]; other site 191026011954 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 191026011955 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 191026011956 adenylate cyclase; Provisional; Region: cyaA; PRK09450 191026011957 Adenylate cyclase NT domain; Region: Adenyl_cycl_N; pfam12633 191026011958 Adenylate cyclase, class-I; Region: Adenylate_cycl; pfam01295 191026011959 HD domain; Region: HD_3; pfam13023 191026011960 CBS domain; Region: CBS; pfam00571 191026011961 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 191026011962 Zn2+ binding site [ion binding]; other site 191026011963 Mg2+ binding site [ion binding]; other site 191026011964 cell division protein MraZ; Reviewed; Region: PRK00326 191026011965 MraZ protein; Region: MraZ; pfam02381 191026011966 MraZ protein; Region: MraZ; pfam02381 191026011967 MraW methylase family; Region: Methyltransf_5; cl17771 191026011968 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 191026011969 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 191026011970 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 191026011971 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 191026011972 PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576 191026011973 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 191026011974 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 191026011975 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 191026011976 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 191026011977 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 191026011978 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Region: murF; TIGR01143 191026011979 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 191026011980 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 191026011981 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 191026011982 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 191026011983 Mg++ binding site [ion binding]; other site 191026011984 putative catalytic motif [active] 191026011985 putative substrate binding site [chemical binding]; other site 191026011986 UDP-N-acetylmuramoylalanine-D-glutamate ligase [Cell envelope biogenesis, outer membrane]; Region: MurD; COG0771 191026011987 Alanine dehydrogenase/PNT, C-terminal domain; Region: AlaDh_PNT_C; smart01002 191026011988 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 191026011989 cell division protein FtsW; Region: ftsW; TIGR02614 191026011990 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 191026011991 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 191026011992 active site 191026011993 homodimer interface [polypeptide binding]; other site 191026011994 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 191026011995 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 191026011996 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 191026011997 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 191026011998 UDP-N-acetylmuramate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: MurB; COG0812 191026011999 FAD binding domain; Region: FAD_binding_4; pfam01565 191026012000 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 191026012001 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 191026012002 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 191026012003 cell division protein FtsA; Region: ftsA; TIGR01174 191026012004 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 191026012005 nucleotide binding site [chemical binding]; other site 191026012006 SHS2 domain inserted in FTSA; Region: SHS2_FTSA; pfam02491 191026012007 Cell division protein FtsA; Region: FtsA; pfam14450 191026012008 cell division protein FtsZ; Validated; Region: PRK09330 191026012009 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 191026012010 nucleotide binding site [chemical binding]; other site 191026012011 SulA interaction site; other site 191026012012 radical SAM family uncharacterized protein; Region: rSAM_fuse_unch; TIGR03960 191026012013 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 191026012014 FeS/SAM binding site; other site 191026012015 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 191026012016 dimer interface [polypeptide binding]; other site 191026012017 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 191026012018 dimer interface [polypeptide binding]; other site 191026012019 Domain of unknown function (DUF4405); Region: DUF4405; pfam14358 191026012020 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 191026012021 PAS domain; Region: PAS; smart00091 191026012022 putative active site [active] 191026012023 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 191026012024 dimer interface [polypeptide binding]; other site 191026012025 phosphorylation site [posttranslational modification] 191026012026 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 191026012027 ATP binding site [chemical binding]; other site 191026012028 Mg2+ binding site [ion binding]; other site 191026012029 G-X-G motif; other site 191026012030 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 191026012031 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 191026012032 active site 191026012033 phosphorylation site [posttranslational modification] 191026012034 intermolecular recognition site; other site 191026012035 dimerization interface [polypeptide binding]; other site 191026012036 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 191026012037 Walker A motif; other site 191026012038 ATP binding site [chemical binding]; other site 191026012039 Walker B motif; other site 191026012040 arginine finger; other site 191026012041 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 191026012042 ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175 191026012043 ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294 191026012044 Walker A/P-loop; other site 191026012045 ATP binding site [chemical binding]; other site 191026012046 Q-loop/lid; other site 191026012047 ABC transporter signature motif; other site 191026012048 Walker B; other site 191026012049 D-loop; other site 191026012050 H-loop/switch region; other site 191026012051 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 191026012052 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 191026012053 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 191026012054 dimer interface [polypeptide binding]; other site 191026012055 conserved gate region; other site 191026012056 putative PBP binding loops; other site 191026012057 ABC-ATPase subunit interface; other site 191026012058 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 191026012059 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 191026012060 HDOD domain; Region: HDOD; pfam08668 191026012061 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 191026012062 Zn2+ binding site [ion binding]; other site 191026012063 Mg2+ binding site [ion binding]; other site 191026012064 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 191026012065 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 191026012066 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 191026012067 HIGH motif; other site 191026012068 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 191026012069 active site 191026012070 KMSKS motif; other site 191026012071 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 191026012072 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 191026012073 substrate binding pocket [chemical binding]; other site 191026012074 membrane-bound complex binding site; other site 191026012075 hinge residues; other site 191026012076 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 191026012077 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 191026012078 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 191026012079 TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358 191026012080 TRAP transporter, 4TM/12TM fusion protein; Region: TRAP_fused; TIGR02123 191026012081 DctM-like transporters; Region: DctM; pfam06808 191026012082 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 191026012083 Uncharacterized ACR, COG1399; Region: DUF177; pfam02620 191026012084 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 191026012085 putative phosphate acyltransferase; Provisional; Region: PRK05331 191026012086 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 191026012087 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 191026012088 dimer interface [polypeptide binding]; other site 191026012089 active site 191026012090 CoA binding pocket [chemical binding]; other site 191026012091 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 191026012092 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 191026012093 NAD(P) binding site [chemical binding]; other site 191026012094 homotetramer interface [polypeptide binding]; other site 191026012095 homodimer interface [polypeptide binding]; other site 191026012096 active site 191026012097 acyl carrier protein; Provisional; Region: acpP; PRK00982 191026012098 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 191026012099 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 191026012100 dimer interface [polypeptide binding]; other site 191026012101 active site 191026012102 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 191026012103 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 191026012104 dimer interface [polypeptide binding]; other site 191026012105 active site 191026012106 glycine-pyridoxal phosphate binding site [chemical binding]; other site 191026012107 folate binding site [chemical binding]; other site 191026012108 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 191026012109 catalytic motif [active] 191026012110 Zn binding site [ion binding]; other site 191026012111 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 191026012112 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 191026012113 catalytic motif [active] 191026012114 Zn binding site [ion binding]; other site 191026012115 RibD C-terminal domain; Region: RibD_C; cl17279 191026012116 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 191026012117 Lumazine binding domain; Region: Lum_binding; pfam00677 191026012118 Lumazine binding domain; Region: Lum_binding; pfam00677 191026012119 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 191026012120 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 191026012121 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 191026012122 dimerization interface [polypeptide binding]; other site 191026012123 active site 191026012124 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 191026012125 homopentamer interface [polypeptide binding]; other site 191026012126 active site 191026012127 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 191026012128 putative RNA binding site [nucleotide binding]; other site 191026012129 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 191026012130 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 191026012131 HIGH motif; other site 191026012132 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 191026012133 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 191026012134 active site 191026012135 KMSKS motif; other site 191026012136 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 191026012137 tRNA binding surface [nucleotide binding]; other site 191026012138 Lipopolysaccharide-assembly; Region: LptE; cl01125 191026012139 DNA polymerase III, delta subunit [DNA replication, recombination, and repair]; Region: HolA; COG1466 191026012140 hypothetical protein; Reviewed; Region: PRK00024 191026012141 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 191026012142 MPN+ (JAMM) motif; other site 191026012143 Zinc-binding site [ion binding]; other site 191026012144 Acylphosphatase; Region: Acylphosphatase; pfam00708 191026012145 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 191026012146 Found in ATP-dependent protease La (LON); Region: LON; smart00464 191026012147 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 191026012148 Walker A motif; other site 191026012149 ATP binding site [chemical binding]; other site 191026012150 Walker B motif; other site 191026012151 arginine finger; other site 191026012152 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 191026012153 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; pfam09723 191026012154 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 191026012155 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 191026012156 domain interfaces; other site 191026012157 active site 191026012158 Pathogenicity locus; Region: Cdd1; pfam11731 191026012159 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195 191026012160 dimerization interface [polypeptide binding]; other site 191026012161 putative ATP binding site [chemical binding]; other site 191026012162 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 191026012163 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 191026012164 putative dimer interface [polypeptide binding]; other site 191026012165 active site pocket [active] 191026012166 putative cataytic base [active] 191026012167 shikimate kinase; Reviewed; Region: aroK; PRK00131 191026012168 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 191026012169 ADP binding site [chemical binding]; other site 191026012170 magnesium binding site [ion binding]; other site 191026012171 putative shikimate binding site; other site 191026012172 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 191026012173 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 191026012174 active site 191026012175 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 191026012176 metal-binding site [ion binding] 191026012177 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 191026012178 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 191026012179 metal-binding site [ion binding] 191026012180 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 191026012181 Soluble P-type ATPase [General function prediction only]; Region: COG4087 191026012182 Arginase-like amidino hydrolase family; Region: Arginase-like_1; cd09999 191026012183 active site 191026012184 Mn binding site [ion binding]; other site 191026012185 TPR repeat; Region: TPR_11; pfam13414 191026012186 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 191026012187 binding surface 191026012188 TPR motif; other site 191026012189 TPR repeat; Region: TPR_11; pfam13414 191026012190 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 191026012191 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 191026012192 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 191026012193 Tetratricopeptide repeat; Region: TPR_12; pfam13424 191026012194 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 191026012195 binding surface 191026012196 TPR motif; other site 191026012197 Tetratricopeptide repeat; Region: TPR_12; pfam13424 191026012198 ABC-type amino acid transport/signal transduction systems, periplasmic component/domain [Amino acid transport and metabolism / Signal transduction mechanisms]; Region: HisJ; COG0834 191026012199 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 191026012200 substrate binding pocket [chemical binding]; other site 191026012201 membrane-bound complex binding site; other site 191026012202 hinge residues; other site 191026012203 FOG: CBS domain [General function prediction only]; Region: COG0517 191026012204 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 191026012205 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 191026012206 Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375 191026012207 Hydrogenase expression/synthesis hypA family; Region: HypA; pfam01155 191026012208 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 191026012209 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 191026012210 PAS domain; Region: PAS_9; pfam13426 191026012211 putative active site [active] 191026012212 heme pocket [chemical binding]; other site 191026012213 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 191026012214 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 191026012215 Walker A motif; other site 191026012216 ATP binding site [chemical binding]; other site 191026012217 Walker B motif; other site 191026012218 arginine finger; other site 191026012219 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 191026012220 Dinitrogenase iron-molybdenum cofactor; Region: Nitro_FeMo-Co; pfam02579 191026012221 This uncharacterized conserved protein belongs to a family of iron-molybdenum cluster-binding proteins that includes NifX, NifB, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of...; Region: MTH1175; cd00851 191026012222 CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656 191026012223 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 191026012224 This uncharacterized conserved protein belongs to a family of iron-molybdenum cluster-binding proteins that includes NifX, NifB, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of...; Region: MTH1175; cd00851 191026012225 Integrase core domain; Region: rve; pfam00665 191026012226 Integrase core domain; Region: rve_3; pfam13683 191026012227 Methyltransferase domain; Region: Methyltransf_23; pfam13489 191026012228 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 191026012229 S-adenosylmethionine binding site [chemical binding]; other site 191026012230 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 191026012231 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 191026012232 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 191026012233 Radical SAM superfamily; Region: Radical_SAM; pfam04055 191026012234 FeS/SAM binding site; other site 191026012235 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 191026012236 Methyltransferase domain; Region: Methyltransf_24; pfam13578 191026012237 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 191026012238 active site 191026012239 asparagine synthase (glutamine-hydrolyzing); Region: asn_synth_AEB; TIGR01536 191026012240 dimer interface [polypeptide binding]; other site 191026012241 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 191026012242 Ligand Binding Site [chemical binding]; other site 191026012243 Molecular Tunnel; other site 191026012244 Protein of unknown function (DUF616); Region: DUF616; pfam04765 191026012245 Methyltransferase domain; Region: Methyltransf_23; pfam13489 191026012246 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 191026012247 S-adenosylmethionine binding site [chemical binding]; other site 191026012248 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 191026012249 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 191026012250 active site 191026012251 Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632 191026012252 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 191026012253 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 191026012254 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 191026012255 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 191026012256 active site 191026012257 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 191026012258 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 191026012259 Transposase; Region: HTH_Tnp_1; pfam01527 191026012260 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 191026012261 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 191026012262 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 191026012263 putative dimer interface [polypeptide binding]; other site 191026012264 Transposase; Region: HTH_Tnp_1; cl17663 191026012265 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; Product type h : extrachromosomal origin 191026012266 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; Product type h : extrachromosomal origin 191026012267 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 191026012268 DNA binding site [nucleotide binding] 191026012269 active site 191026012270 Int/Topo IB signature motif; other site 191026012271 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 191026012272 salt bridge; other site 191026012273 non-specific DNA binding site [nucleotide binding]; other site 191026012274 sequence-specific DNA binding site [nucleotide binding]; other site 191026012275 HipA N-terminal domain; Region: Couple_hipA; cl11853 191026012276 HipA-like N-terminal domain; Region: HipA_N; pfam07805 191026012277 HipA-like C-terminal domain; Region: HipA_C; pfam07804 191026012278 Fic family protein [Function unknown]; Region: COG3177 191026012279 Fic/DOC family; Region: Fic; pfam02661 191026012280 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 191026012281 Transposase; Region: HTH_Tnp_1; cl17663 191026012282 Integrase core domain; Region: rve_3; pfam13683 191026012283 Protein of unknown function (DUF554); Region: DUF554; pfam04474 191026012284 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 191026012285 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 191026012286 dimerization interface [polypeptide binding]; other site 191026012287 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 191026012288 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 191026012289 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 191026012290 ornithine--oxo-acid transaminase; Reviewed; Region: rocD; PRK00854 191026012291 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 191026012292 inhibitor-cofactor binding pocket; inhibition site 191026012293 pyridoxal 5'-phosphate binding site [chemical binding]; other site 191026012294 catalytic residue [active] 191026012295 Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292 191026012296 Two component regulator propeller; Region: Reg_prop; pfam07494 191026012297 Two component regulator propeller; Region: Reg_prop; pfam07494 191026012298 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 191026012299 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 191026012300 dimer interface [polypeptide binding]; other site 191026012301 phosphorylation site [posttranslational modification] 191026012302 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 191026012303 ATP binding site [chemical binding]; other site 191026012304 Mg2+ binding site [ion binding]; other site 191026012305 G-X-G motif; other site 191026012306 Response regulator receiver domain; Region: Response_reg; pfam00072 191026012307 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 191026012308 active site 191026012309 phosphorylation site [posttranslational modification] 191026012310 intermolecular recognition site; other site 191026012311 dimerization interface [polypeptide binding]; other site 191026012312 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 191026012313 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 191026012314 putative active site [active] 191026012315 heme pocket [chemical binding]; other site 191026012316 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 191026012317 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 191026012318 putative active site [active] 191026012319 heme pocket [chemical binding]; other site 191026012320 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 191026012321 dimer interface [polypeptide binding]; other site 191026012322 phosphorylation site [posttranslational modification] 191026012323 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 191026012324 ATP binding site [chemical binding]; other site 191026012325 Mg2+ binding site [ion binding]; other site 191026012326 G-X-G motif; other site 191026012327 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 191026012328 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 191026012329 active site 191026012330 phosphorylation site [posttranslational modification] 191026012331 intermolecular recognition site; other site 191026012332 dimerization interface [polypeptide binding]; other site 191026012333 Putative pyruvate format-lyase activating enzyme (DUF1786); Region: DUF1786; cl01638 191026012334 HEAT repeats; Region: HEAT_2; pfam13646 191026012335 HEAT repeats; Region: HEAT_2; pfam13646 191026012336 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 191026012337 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 191026012338 active site 191026012339 phosphorylation site [posttranslational modification] 191026012340 intermolecular recognition site; other site 191026012341 dimerization interface [polypeptide binding]; other site 191026012342 Predicted inhibitor of MCP methylation, homolog of CheC [Cell motility and secretion]; Region: COG1406 191026012343 Chemotaxis phosphatase CheX; Region: CheX; pfam13690 191026012344 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 191026012345 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 191026012346 Cl- selectivity filter; other site 191026012347 Cl- binding residues [ion binding]; other site 191026012348 pore gating glutamate residue; other site 191026012349 dimer interface [polypeptide binding]; other site 191026012350 FOG: CBS domain [General function prediction only]; Region: COG0517 191026012351 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 191026012352 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 191026012353 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 191026012354 substrate binding pocket [chemical binding]; other site 191026012355 membrane-bound complex binding site; other site 191026012356 hinge residues; other site 191026012357 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 191026012358 Zn2+ binding site [ion binding]; other site 191026012359 Mg2+ binding site [ion binding]; other site 191026012360 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 191026012361 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 191026012362 glutaminase active site [active] 191026012363 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 191026012364 dimer interface [polypeptide binding]; other site 191026012365 active site 191026012366 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 191026012367 dimer interface [polypeptide binding]; other site 191026012368 active site 191026012369 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 191026012370 active site 191026012371 dimerization interface [polypeptide binding]; other site 191026012372 PAS fold; Region: PAS_4; pfam08448 191026012373 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 191026012374 dimer interface [polypeptide binding]; other site 191026012375 phosphorylation site [posttranslational modification] 191026012376 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 191026012377 ATP binding site [chemical binding]; other site 191026012378 Mg2+ binding site [ion binding]; other site 191026012379 G-X-G motif; other site 191026012380 ribosomal protein S12 methylthiotransferase RimO; Region: TIGR01125 191026012381 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 191026012382 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377 191026012383 FeS/SAM binding site; other site 191026012384 Peptidase family C25; Region: Peptidase_C25; pfam01364 191026012385 active site 191026012386 Sporulation related domain; Region: SPOR; pfam05036 191026012387 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 191026012388 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 191026012389 putative active site [active] 191026012390 Domain of unknown function (DUF202); Region: DUF202; cl09954 191026012391 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 191026012392 active site 191026012393 UDP-N-acetylglucosamine 2-epimerase; Region: Epimerase_2; pfam02350 191026012394 homodimer interface [polypeptide binding]; other site 191026012395 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 191026012396 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 191026012397 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 191026012398 active site 191026012399 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 191026012400 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 191026012401 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 191026012402 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 191026012403 Winged helix-turn helix; Region: HTH_29; pfam13551 191026012404 Helix-turn-helix domain; Region: HTH_28; pfam13518 191026012405 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 191026012406 Integrase core domain; Region: rve; pfam00665 191026012407 Integrase core domain; Region: rve_3; pfam13683 191026012408 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 191026012409 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 191026012410 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 191026012411 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 191026012412 transmembrane helices; other site 191026012413 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 191026012414 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 191026012415 active site 191026012416 PHP Thumb interface [polypeptide binding]; other site 191026012417 metal binding site [ion binding]; metal-binding site 191026012418 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 191026012419 generic binding surface II; other site 191026012420 generic binding surface I; other site 191026012421 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 191026012422 active site 191026012423 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 191026012424 putative active site [active] 191026012425 dimerization interface [polypeptide binding]; other site 191026012426 putative tRNAtyr binding site [nucleotide binding]; other site 191026012427 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 191026012428 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 191026012429 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 191026012430 anti sigma factor interaction site; other site 191026012431 regulatory phosphorylation site [posttranslational modification]; other site 191026012432 Protein of unknown function (DUF342); Region: DUF342; pfam03961 191026012433 Protein of unknown function (DUF2869); Region: DUF2869; pfam11068 191026012434 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 191026012435 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 191026012436 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 191026012437 flagellar motor protein MotS; Reviewed; Region: PRK06925 191026012438 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 191026012439 ligand binding site [chemical binding]; other site 191026012440 DUF based on E. rectale Gene description (DUF3880); Region: DUF3880; pfam12996 191026012441 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 191026012442 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; pfam09723 191026012443 CHASE4 domain; Region: CHASE4; pfam05228 191026012444 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 191026012445 dimer interface [polypeptide binding]; other site 191026012446 phosphorylation site [posttranslational modification] 191026012447 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 191026012448 ATP binding site [chemical binding]; other site 191026012449 Mg2+ binding site [ion binding]; other site 191026012450 G-X-G motif; other site 191026012451 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 191026012452 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 191026012453 active site 191026012454 HIGH motif; other site 191026012455 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 191026012456 KMSKS motif; other site 191026012457 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 191026012458 tRNA binding surface [nucleotide binding]; other site 191026012459 anticodon binding site; other site 191026012460 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 191026012461 bifunctional 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase/2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase protein; Provisional; Region: ispDF; PRK09382 191026012462 substrate binding site; other site 191026012463 dimer interface; other site 191026012464 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 191026012465 homotrimer interaction site [polypeptide binding]; other site 191026012466 zinc binding site [ion binding]; other site 191026012467 CDP-binding sites; other site 191026012468 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 191026012469 Putative zinc ribbon domain; Region: DUF164; pfam02591 191026012470 Uncharacterized conserved protein [Function unknown]; Region: COG0327 191026012471 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 191026012472 ADP-heptose synthase, bifunctional sugar kinase/adenylyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaE; COG2870 191026012473 rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199 191026012474 active site 191026012475 HIGH motif; other site 191026012476 nucleotide binding site [chemical binding]; other site 191026012477 Domain of unknown function (DUF955); Region: DUF955; pfam06114 191026012478 Flagellin N-methylase; Region: FliB; pfam03692 191026012479 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 191026012480 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 191026012481 active site 191026012482 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 191026012483 putative active site [active] 191026012484 putative metal binding site [ion binding]; other site 191026012485 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 191026012486 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 191026012487 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 191026012488 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 191026012489 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 191026012490 dimer interface [polypeptide binding]; other site 191026012491 conserved gate region; other site 191026012492 putative PBP binding loops; other site 191026012493 ABC-ATPase subunit interface; other site 191026012494 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 191026012495 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 191026012496 dimer interface [polypeptide binding]; other site 191026012497 conserved gate region; other site 191026012498 putative PBP binding loops; other site 191026012499 ABC-ATPase subunit interface; other site 191026012500 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 191026012501 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 191026012502 substrate binding pocket [chemical binding]; other site 191026012503 membrane-bound complex binding site; other site 191026012504 hinge residues; other site 191026012505 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 191026012506 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 191026012507 Walker A/P-loop; other site 191026012508 ATP binding site [chemical binding]; other site 191026012509 Q-loop/lid; other site 191026012510 ABC transporter signature motif; other site 191026012511 Walker B; other site 191026012512 D-loop; other site 191026012513 H-loop/switch region; other site 191026012514 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 191026012515 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 191026012516 active site 191026012517 phosphorylation site [posttranslational modification] 191026012518 intermolecular recognition site; other site 191026012519 dimerization interface [polypeptide binding]; other site 191026012520 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 191026012521 Walker A motif; other site 191026012522 ATP binding site [chemical binding]; other site 191026012523 Walker B motif; other site 191026012524 arginine finger; other site 191026012525 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 191026012526 seryl-tRNA synthetase; Provisional; Region: PRK05431 191026012527 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 191026012528 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 191026012529 dimer interface [polypeptide binding]; other site 191026012530 active site 191026012531 motif 1; other site 191026012532 motif 2; other site 191026012533 motif 3; other site 191026012534 Competence-damaged protein; Region: CinA; pfam02464 191026012535 Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966 191026012536 2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258 191026012537 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 191026012538 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 191026012539 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 191026012540 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 191026012541 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 191026012542 protein binding site [polypeptide binding]; other site 191026012543 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 191026012544 heat shock protein HtpX; Provisional; Region: PRK03982 191026012545 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 191026012546 PAS domain S-box; Region: sensory_box; TIGR00229 191026012547 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 191026012548 putative active site [active] 191026012549 heme pocket [chemical binding]; other site 191026012550 PAS fold; Region: PAS_4; pfam08448 191026012551 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 191026012552 putative active site [active] 191026012553 heme pocket [chemical binding]; other site 191026012554 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 191026012555 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 191026012556 dimer interface [polypeptide binding]; other site 191026012557 phosphorylation site [posttranslational modification] 191026012558 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 191026012559 ATP binding site [chemical binding]; other site 191026012560 Mg2+ binding site [ion binding]; other site 191026012561 G-X-G motif; other site 191026012562 FecR protein; Region: FecR; pfam04773 191026012563 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 191026012564 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 191026012565 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 191026012566 active site 191026012567 dimerization interface [polypeptide binding]; other site 191026012568 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 191026012569 binding surface 191026012570 TPR motif; other site 191026012571 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 191026012572 TPR motif; other site 191026012573 TPR repeat; Region: TPR_11; pfam13414 191026012574 binding surface 191026012575 Tetratricopeptide repeat; Region: TPR_12; pfam13424 191026012576 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 191026012577 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 191026012578 tandem repeat interface [polypeptide binding]; other site 191026012579 oligomer interface [polypeptide binding]; other site 191026012580 active site residues [active] 191026012581 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 191026012582 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 191026012583 RNA binding site [nucleotide binding]; other site 191026012584 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 191026012585 RNA binding site [nucleotide binding]; other site 191026012586 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 191026012587 RNA binding site [nucleotide binding]; other site 191026012588 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 191026012589 RNA binding site [nucleotide binding]; other site 191026012590 S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec5; cd05690 191026012591 RNA binding site [nucleotide binding]; other site 191026012592 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 191026012593 RNA binding site [nucleotide binding]; other site 191026012594 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 191026012595 PhoU domain; Region: PhoU; pfam01895 191026012596 PhoU domain; Region: PhoU; pfam01895 191026012597 phosphate transporter ATP-binding protein; Provisional; Region: PRK14242 191026012598 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 191026012599 Walker A/P-loop; other site 191026012600 ATP binding site [chemical binding]; other site 191026012601 Q-loop/lid; other site 191026012602 ABC transporter signature motif; other site 191026012603 Walker B; other site 191026012604 D-loop; other site 191026012605 H-loop/switch region; other site 191026012606 AMIN domain; Region: AMIN; pfam11741 191026012607 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 191026012608 homodimer interface [polypeptide binding]; other site 191026012609 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 191026012610 active site pocket [active] 191026012611 ROS/MUCR transcriptional regulator protein; Region: ROS_MUCR; pfam05443 191026012612 flagellar motor protein MotS; Reviewed; Region: PRK06925 191026012613 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 191026012614 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 191026012615 ligand binding site [chemical binding]; other site 191026012616 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 191026012617 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 191026012618 active site 191026012619 phosphorylation site [posttranslational modification] 191026012620 intermolecular recognition site; other site 191026012621 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 191026012622 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 191026012623 hexamer interface [polypeptide binding]; other site 191026012624 ligand binding site [chemical binding]; other site 191026012625 putative active site [active] 191026012626 NAD(P) binding site [chemical binding]; other site 191026012627 Response regulator receiver domain; Region: Response_reg; pfam00072 191026012628 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 191026012629 active site 191026012630 phosphorylation site [posttranslational modification] 191026012631 intermolecular recognition site; other site 191026012632 dimerization interface [polypeptide binding]; other site 191026012633 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 191026012634 Protein of unknwon function (DUF2893); Region: DUF2893; pfam11459 191026012635 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843 191026012636 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 191026012637 dimer interface [polypeptide binding]; other site 191026012638 catalytic triad [active] 191026012639 peroxidatic and resolving cysteines [active] 191026012640 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 191026012641 active site 191026012642 catalytic residues [active] 191026012643 DNA binding site [nucleotide binding] 191026012644 Int/Topo IB signature motif; other site 191026012645 TOBE domain; Region: TOBE; cl01440 191026012646 TOBE domain; Region: TOBE; cl01440 191026012647 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 191026012648 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 191026012649 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 191026012650 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 191026012651 dimer interface [polypeptide binding]; other site 191026012652 conserved gate region; other site 191026012653 putative PBP binding loops; other site 191026012654 ABC-ATPase subunit interface; other site 191026012655 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4136 191026012656 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 191026012657 Walker A/P-loop; other site 191026012658 ATP binding site [chemical binding]; other site 191026012659 Q-loop/lid; other site 191026012660 ABC transporter signature motif; other site 191026012661 Walker B; other site 191026012662 D-loop; other site 191026012663 H-loop/switch region; other site 191026012664 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 191026012665 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 191026012666 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 191026012667 dimer interface [polypeptide binding]; other site 191026012668 conserved gate region; other site 191026012669 putative PBP binding loops; other site 191026012670 ABC-ATPase subunit interface; other site 191026012671 Uncharacterized conserved protein [Function unknown]; Region: COG2014 191026012672 Domain of unknown function (DUF364); Region: DUF364; pfam04016 191026012673 mycothiol synthase; Region: mycothiol_MshD; TIGR03448 191026012674 MoeA_like. This domain is similar to a domain found in a variety of proteins involved in biosynthesis of molybdopterin cofactor, like MoaB, MogA, and MoeA. There this domain is presumed to bind molybdopterin. The exact function of this subgroup is...; Region: MoeA_like; cd03522 191026012675 putative MPT binding site; other site 191026012676 4-hydroxybenzoyl-CoA reductase, gamma subunit; Region: 4hydroxCoAred; TIGR03193 191026012677 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 191026012678 catalytic loop [active] 191026012679 iron binding site [ion binding]; other site 191026012680 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 191026012681 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 191026012682 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 191026012683 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 191026012684 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 191026012685 Methyltransferase domain; Region: Methyltransf_23; pfam13489 191026012686 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 191026012687 S-adenosylmethionine binding site [chemical binding]; other site 191026012688 Putative redox-active protein (C_GCAxxG_C_C); Region: C_GCAxxG_C_C; pfam09719 191026012689 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG1964 191026012690 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 191026012691 FeS/SAM binding site; other site 191026012692 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 191026012693 phenylacetate-CoA ligase; Region: PA_CoA_ligase; TIGR02155 191026012694 acyl-activating enzyme (AAE) consensus motif; other site 191026012695 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 191026012696 AMP binding site [chemical binding]; other site 191026012697 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 191026012698 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 191026012699 XdhC Rossmann domain; Region: XdhC_C; pfam13478 191026012700 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 191026012701 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 191026012702 Ligand binding site; other site 191026012703 metal-binding site 191026012704 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 191026012705 Zn2+ binding site [ion binding]; other site 191026012706 Mg2+ binding site [ion binding]; other site 191026012707 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 191026012708 catalytic core [active] 191026012709 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 191026012710 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 191026012711 active site 191026012712 NAD binding site [chemical binding]; other site 191026012713 metal binding site [ion binding]; metal-binding site 191026012714 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 191026012715 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 191026012716 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 191026012717 dimer interface [polypeptide binding]; other site 191026012718 phosphorylation site [posttranslational modification] 191026012719 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 191026012720 ATP binding site [chemical binding]; other site 191026012721 Mg2+ binding site [ion binding]; other site 191026012722 G-X-G motif; other site 191026012723 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 191026012724 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 191026012725 active site 191026012726 phosphorylation site [posttranslational modification] 191026012727 intermolecular recognition site; other site 191026012728 dimerization interface [polypeptide binding]; other site 191026012729 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 191026012730 Walker A motif; other site 191026012731 ATP binding site [chemical binding]; other site 191026012732 Walker B motif; other site 191026012733 arginine finger; other site 191026012734 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 191026012735 Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176 191026012736 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 191026012737 dimer interface [polypeptide binding]; other site 191026012738 active site 191026012739 metal binding site [ion binding]; metal-binding site 191026012740 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 191026012741 nitrogen fixation negative regulator NifL; Region: nifL_nitrog; TIGR02938 191026012742 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 191026012743 putative active site [active] 191026012744 heme pocket [chemical binding]; other site 191026012745 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 191026012746 ATP binding site [chemical binding]; other site 191026012747 Mg2+ binding site [ion binding]; other site 191026012748 G-X-G motif; other site 191026012749 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 191026012750 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 191026012751 substrate binding pocket [chemical binding]; other site 191026012752 membrane-bound complex binding site; other site 191026012753 hinge residues; other site 191026012754 Response regulator receiver domain; Region: Response_reg; pfam00072 191026012755 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 191026012756 active site 191026012757 phosphorylation site [posttranslational modification] 191026012758 intermolecular recognition site; other site 191026012759 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 191026012760 dimerization interface [polypeptide binding]; other site 191026012761 HD domain; Region: HD_5; pfam13487 191026012762 Response regulator receiver domain; Region: Response_reg; pfam00072 191026012763 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 191026012764 active site 191026012765 phosphorylation site [posttranslational modification] 191026012766 intermolecular recognition site; other site 191026012767 dimerization interface [polypeptide binding]; other site 191026012768 HDOD domain; Region: HDOD; pfam08668 191026012769 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 191026012770 Zn2+ binding site [ion binding]; other site 191026012771 Mg2+ binding site [ion binding]; other site 191026012772 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 191026012773 Methyltransferase domain; Region: Methyltransf_23; pfam13489 191026012774 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 191026012775 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 191026012776 putative catalytic site [active] 191026012777 putative metal binding site [ion binding]; other site 191026012778 putative phosphate binding site [ion binding]; other site 191026012779 rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565 191026012780 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 191026012781 Tetratricopeptide repeat; Region: TPR_16; pfam13432 191026012782 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 191026012783 binding surface 191026012784 TPR motif; other site 191026012785 TPR repeat; Region: TPR_11; pfam13414 191026012786 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 191026012787 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 191026012788 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 191026012789 catalytic triad [active] 191026012790 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 191026012791 active site 191026012792 DNA polymerase IV; Validated; Region: PRK02406 191026012793 DNA binding site [nucleotide binding] 191026012794 cobalt-precorrin-6A synthase; Reviewed; Region: cbiD; PRK00075 191026012795 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 191026012796 active site 191026012797 putative homodimer interface [polypeptide binding]; other site 191026012798 SAM binding site [chemical binding]; other site 191026012799 Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242 191026012800 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 191026012801 S-adenosylmethionine binding site [chemical binding]; other site 191026012802 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 191026012803 Diphthamide biosynthesis methyltransferase [Translation, ribosomal structure and biogenesis]; Region: DPH5; COG1798 191026012804 active site 191026012805 SAM binding site [chemical binding]; other site 191026012806 homodimer interface [polypeptide binding]; other site 191026012807 Uncharacterized protein family UPF0047; Region: UPF0047; pfam01894 191026012808 Domain of unknown function (DUF4389); Region: DUF4389; pfam14333 191026012809 Cache domain; Region: Cache_1; pfam02743 191026012810 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 191026012811 dimerization interface [polypeptide binding]; other site 191026012812 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 191026012813 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 191026012814 Cysteine-rich small domain; Region: zf-like; cl00946 191026012815 AmmeMemoRadiSam system protein A; Region: AmmeMemoSam_A; TIGR04335 191026012816 AMMECR1; Region: AMMECR1; pfam01871 191026012817 Phosphotransferase enzyme family; Region: APH; pfam01636 191026012818 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 191026012819 active site 191026012820 ATP binding site [chemical binding]; other site 191026012821 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 191026012822 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 191026012823 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 191026012824 active site 191026012825 substrate binding site [chemical binding]; other site 191026012826 cosubstrate binding site; other site 191026012827 catalytic site [active] 191026012828 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 191026012829 Diphthamide biosynthesis methyltransferase [Translation, ribosomal structure and biogenesis]; Region: DPH5; COG1798 191026012830 active site 191026012831 SAM binding site [chemical binding]; other site 191026012832 homodimer interface [polypeptide binding]; other site 191026012833 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 191026012834 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 191026012835 active site 191026012836 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 191026012837 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 191026012838 HIGH motif; other site 191026012839 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 191026012840 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 191026012841 active site 191026012842 KMSKS motif; other site 191026012843 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 191026012844 tRNA binding surface [nucleotide binding]; other site 191026012845 anticodon binding site; other site 191026012846 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 191026012847 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 191026012848 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 191026012849 Permease; Region: Permease; pfam02405 191026012850 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 191026012851 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 191026012852 Walker A/P-loop; other site 191026012853 ATP binding site [chemical binding]; other site 191026012854 Q-loop/lid; other site 191026012855 ABC transporter signature motif; other site 191026012856 Walker B; other site 191026012857 D-loop; other site 191026012858 H-loop/switch region; other site 191026012859 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 191026012860 mce related protein; Region: MCE; pfam02470 191026012861 Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; pfam05494 191026012862 VacJ like lipoprotein; Region: VacJ; cl01073 191026012863 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 191026012864 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 191026012865 active site 191026012866 metal binding site [ion binding]; metal-binding site 191026012867 homotetramer interface [polypeptide binding]; other site 191026012868 Multiple antibiotic transporter [Intracellular trafficking and secretion]; Region: MarC; COG2095 191026012869 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 191026012870 DEAD/DEAH box helicase; Region: DEAD; pfam00270 191026012871 ATP binding site [chemical binding]; other site 191026012872 putative Mg++ binding site [ion binding]; other site 191026012873 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 191026012874 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 191026012875 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 191026012876 FAD binding domain; Region: FAD_binding_4; pfam01565 191026012877 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 191026012878 Transcriptional regulator [Transcription]; Region: LysR; COG0583 191026012879 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 191026012880 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 191026012881 dimerization interface [polypeptide binding]; other site 191026012882 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 191026012883 SmpB-tmRNA interface; other site 191026012884 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 191026012885 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 191026012886 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 191026012887 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 191026012888 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 191026012889 dimerization domain swap beta strand [polypeptide binding]; other site 191026012890 regulatory protein interface [polypeptide binding]; other site 191026012891 active site 191026012892 regulatory phosphorylation site [posttranslational modification]; other site 191026012893 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; cl01507 191026012894 Predicted methyltransferases [General function prediction only]; Region: COG0313 191026012895 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 191026012896 putative SAM binding site [chemical binding]; other site 191026012897 putative homodimer interface [polypeptide binding]; other site 191026012898 Uncharacterized protein family UPF0102; Region: UPF0102; cl00516 191026012899 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 191026012900 RNA/DNA hybrid binding site [nucleotide binding]; other site 191026012901 active site 191026012902 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 191026012903 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 191026012904 SAM-dependent RNA methyltransferase; Region: Methyltrn_RNA_4; pfam09936 191026012905 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 191026012906 RimM N-terminal domain; Region: RimM; pfam01782 191026012907 PRC-barrel domain; Region: PRC; pfam05239 191026012908 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 191026012909 hypothetical protein; Provisional; Region: PRK00468 191026012910 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 191026012911 signal recognition particle protein; Provisional; Region: PRK10867 191026012912 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 191026012913 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 191026012914 P loop; other site 191026012915 GTP binding site [chemical binding]; other site 191026012916 Signal peptide binding domain; Region: SRP_SPB; pfam02978 191026012917 tRNA_anti-like; Region: tRNA_anti-like; pfam12869 191026012918 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 191026012919 Cysteine-rich domain; Region: CCG; pfam02754 191026012920 Cysteine-rich domain; Region: CCG; pfam02754 191026012921 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 191026012922 putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347 191026012923 RsbT co-antagonist protein rsbRD N-terminal domain; Region: RsbRD_N; pfam14361 191026012924 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; cl00959 191026012925 4Fe-4S dicluster domain; Region: Fer4_17; pfam13534 191026012926 Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437 191026012927 4Fe-4S binding domain; Region: Fer4_6; pfam12837 191026012928 Polysulphide reductase [Energy production and conversion]; Region: COG5557; cl17901 191026012929 Polysulphide reductase, NrfD; Region: NrfD; pfam03916 191026012930 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 191026012931 Ligand Binding Site [chemical binding]; other site 191026012932 Protein of unknown function (DUF342); Region: DUF342; pfam03961 191026012933 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 191026012934 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 191026012935 dimerization interface 3.5A [polypeptide binding]; other site 191026012936 active site 191026012937 Uncharacterized conserved protein [Function unknown]; Region: COG3334 191026012938 flagellar export protein FliJ; Region: flagell_FliJ; TIGR02473 191026012939 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily. Adenine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_I; cd01990 191026012940 Ligand Binding Site [chemical binding]; other site 191026012941 4Fe-4S single cluster domain; Region: Fer4_13; pfam13370 191026012942 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 191026012943 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 191026012944 Walker A/P-loop; other site 191026012945 ATP binding site [chemical binding]; other site 191026012946 Q-loop/lid; other site 191026012947 ABC transporter signature motif; other site 191026012948 Walker B; other site 191026012949 D-loop; other site 191026012950 H-loop/switch region; other site 191026012951 leucine/isoleucine/valine transporter permease subunit; Provisional; Region: livM; PRK11301 191026012952 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 191026012953 TM-ABC transporter signature motif; other site 191026012954 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 191026012955 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 191026012956 TM-ABC transporter signature motif; other site 191026012957 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 191026012958 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 191026012959 dimerization interface [polypeptide binding]; other site 191026012960 ligand binding site [chemical binding]; other site 191026012961 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 191026012962 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 191026012963 Walker A/P-loop; other site 191026012964 ATP binding site [chemical binding]; other site 191026012965 Q-loop/lid; other site 191026012966 ABC transporter signature motif; other site 191026012967 Walker B; other site 191026012968 D-loop; other site 191026012969 H-loop/switch region; other site 191026012970 chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169 191026012971 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 191026012972 4Fe-4S dicluster domain; Region: Fer4_17; pfam13534 191026012973 tricarballylate utilization protein B; Provisional; Region: PRK15033 191026012974 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; cl00959 191026012975 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 191026012976 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 191026012977 Methyl-viologen-reducing hydrogenase, delta subunit; Region: FlpD; cl00831 191026012978 Heterodisulfide reductase, subunit A and related polyferredoxins [Energy production and conversion]; Region: HdrA; COG1148 191026012979 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 191026012980 adenosine phosphosulphate reductase, alpha subunit; Region: aprA; TIGR02061 191026012981 adenosine phosphosulphate reductase, beta subunit; Region: aprB; TIGR02060 191026012982 Adenosine-5'-phosphosulfate reductase beta subunit; Region: APS-reductase_C; pfam12139 191026012983 sulfate adenylyltransferase; Reviewed; Region: sat; PRK04149 191026012984 ATP-sulfurylase; Region: ATPS; cd00517 191026012985 active site 191026012986 HXXH motif; other site 191026012987 flexible loop; other site 191026012988 Chorismate mutase [Amino acid transport and metabolism]; Region: PheA; COG1605 191026012989 5-enolpyruvylshikimate-3-phosphate synthase [Amino acid transport and metabolism]; Region: AroA; COG0128 191026012990 This domain family includes the Enolpyruvate transferase (EPT) family and the RNA 3' phosphate cyclase family (RTPC). These 2 families differ in that EPT is formed by 3 repeats of an alpha-beta structural domain while RTPC has 3 similar repeats...; Region: EPT_RTPC-like; cl00288 191026012991 putative active site [active] 191026012992 aconitate hydratase; Validated; Region: PRK07229 191026012993 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 191026012994 substrate binding site [chemical binding]; other site 191026012995 ligand binding site [chemical binding]; other site 191026012996 Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215 191026012997 substrate binding site [chemical binding]; other site 191026012998 periplasmic folding chaperone; Provisional; Region: PRK10788 191026012999 SurA N-terminal domain; Region: SurA_N_3; cl07813 191026013000 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 191026013001 PPIC-type PPIASE domain; Region: Rotamase_2; cl08278 191026013002 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 191026013003 heterotetramer interface [polypeptide binding]; other site 191026013004 active site pocket [active] 191026013005 cleavage site 191026013006 HD domain; Region: HD_3; pfam13023 191026013007 histidinol-phosphate aminotransferase; Validated; Region: PRK02731 191026013008 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 191026013009 pyridoxal 5'-phosphate binding site [chemical binding]; other site 191026013010 homodimer interface [polypeptide binding]; other site 191026013011 catalytic residue [active] 191026013012 cytidylate kinase; Provisional; Region: cmk; PRK00023 191026013013 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 191026013014 CMP-binding site; other site 191026013015 The sites determining sugar specificity; other site 191026013016 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 191026013017 Zn2+ binding site [ion binding]; other site 191026013018 Mg2+ binding site [ion binding]; other site 191026013019 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 191026013020 Haloacid dehalogenase-like hydrolase; Region: Hydrolase_6; pfam13344 191026013021 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 191026013022 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 191026013023 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 191026013024 UDP-galactopyranose mutase; Region: GLF; pfam03275 191026013025 HflC protein; Region: hflC; TIGR01932 191026013026 Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405 191026013027 Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404 191026013028 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 191026013029 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 191026013030 phosphoglucosamine mutase; Region: Arch_GlmM; TIGR03990 191026013031 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 191026013032 active site 191026013033 substrate binding site [chemical binding]; other site 191026013034 metal binding site [ion binding]; metal-binding site 191026013035 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 191026013036 RNA/DNA hybrid binding site [nucleotide binding]; other site 191026013037 active site 191026013038 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 191026013039 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 191026013040 acyl-activating enzyme (AAE) consensus motif; other site 191026013041 AMP binding site [chemical binding]; other site 191026013042 active site 191026013043 CoA binding site [chemical binding]; other site 191026013044 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 191026013045 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 191026013046 non-specific DNA binding site [nucleotide binding]; other site 191026013047 salt bridge; other site 191026013048 sequence-specific DNA binding site [nucleotide binding]; other site 191026013049 Cupin domain; Region: Cupin_2; pfam07883 191026013050 AMP-binding domain protein; Validated; Region: PRK08315 191026013051 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 191026013052 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 191026013053 acyl-activating enzyme (AAE) consensus motif; other site 191026013054 acyl-activating enzyme (AAE) consensus motif; other site 191026013055 putative AMP binding site [chemical binding]; other site 191026013056 putative active site [active] 191026013057 putative CoA binding site [chemical binding]; other site 191026013058 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 191026013059 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 191026013060 non-specific DNA binding site [nucleotide binding]; other site 191026013061 salt bridge; other site 191026013062 sequence-specific DNA binding site [nucleotide binding]; other site 191026013063 Cupin domain; Region: Cupin_2; pfam07883 191026013064 Tetratricopeptide repeat; Region: TPR_12; pfam13424 191026013065 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 191026013066 binding surface 191026013067 TPR motif; other site 191026013068 TPR repeat; Region: TPR_11; pfam13414 191026013069 ribosomal RNA small subunit methyltransferase RsmB; Region: rsmB; TIGR00563 191026013070 NusB family; Region: NusB; pfam01029 191026013071 NOL1/NOP2/sun family putative RNA methylase; Region: nop2p; TIGR00446 191026013072 Protein of unknown function DUF116; Region: DUF116; pfam01976 191026013073 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 191026013074 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 191026013075 putative active site [active] 191026013076 substrate binding site [chemical binding]; other site 191026013077 putative cosubstrate binding site; other site 191026013078 catalytic site [active] 191026013079 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 191026013080 substrate binding site [chemical binding]; other site 191026013081 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 191026013082 active site 191026013083 catalytic residues [active] 191026013084 metal binding site [ion binding]; metal-binding site 191026013085 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 191026013086 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 191026013087 dimer interface [polypeptide binding]; other site 191026013088 anticodon binding site; other site 191026013089 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 191026013090 homodimer interface [polypeptide binding]; other site 191026013091 motif 1; other site 191026013092 active site 191026013093 motif 2; other site 191026013094 GAD domain; Region: GAD; pfam02938 191026013095 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 191026013096 motif 3; other site 191026013097 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 191026013098 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 191026013099 dimer interface [polypeptide binding]; other site 191026013100 motif 1; other site 191026013101 active site 191026013102 motif 2; other site 191026013103 motif 3; other site 191026013104 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 191026013105 anticodon binding site; other site 191026013106 Protein of unknown function (DUF2628); Region: DUF2628; pfam10947 191026013107 Caspase domain; Region: Peptidase_C14; pfam00656 191026013108 tRNA(1-methyladenosine) methyltransferase and related methyltransferases [Translation, ribosomal structure and biogenesis]; Region: GCD14; COG2519 191026013109 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 191026013110 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 191026013111 Radical SAM superfamily; Region: Radical_SAM; pfam04055 191026013112 FeS/SAM binding site; other site 191026013113 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 191026013114 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 191026013115 homodimer interface [polypeptide binding]; other site 191026013116 oligonucleotide binding site [chemical binding]; other site 191026013117 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases and ATP sulphurylases. The domain forms a apha/beta/apha fold which binds to Adenosine group; Region: Alpha_ANH_like; cd01986 191026013118 Ligand Binding Site [chemical binding]; other site 191026013119 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 191026013120 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 191026013121 Ligand Binding Site [chemical binding]; other site 191026013122 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 191026013123 Ligand Binding Site [chemical binding]; other site 191026013124 Coproporphyrinogen III oxidase and related Fe-S oxidoreductases [Coenzyme metabolism]; Region: HemN; COG0635 191026013125 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 191026013126 FeS/SAM binding site; other site 191026013127 HemN C-terminal domain; Region: HemN_C; pfam06969 191026013128 serine O-acetyltransferase; Region: cysE; TIGR01172 191026013129 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 191026013130 trimer interface [polypeptide binding]; other site 191026013131 active site 191026013132 substrate binding site [chemical binding]; other site 191026013133 CoA binding site [chemical binding]; other site 191026013134 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 191026013135 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 191026013136 dimer interface [polypeptide binding]; other site 191026013137 pyridoxal 5'-phosphate binding site [chemical binding]; other site 191026013138 catalytic residue [active] 191026013139 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 191026013140 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 191026013141 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 191026013142 catalytic residue [active] 191026013143 Fe-S cluster assembly protein NifU; Region: NifU_proper; TIGR02000 191026013144 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 191026013145 trimerization site [polypeptide binding]; other site 191026013146 active site 191026013147 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 191026013148 NifU-like domain; Region: NifU; pfam01106 191026013149 butyrate kinase; Provisional; Region: PRK03011 191026013150 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 191026013151 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 191026013152 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 191026013153 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 191026013154 Protein of unknown function (DUF1007); Region: DUF1007; cl01487 191026013155 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG2215 191026013156 Catalytic domain of Protein Kinases; Region: PKc; cd00180 191026013157 active site 191026013158 ATP binding site [chemical binding]; other site 191026013159 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 191026013160 substrate binding site [chemical binding]; other site 191026013161 activation loop (A-loop); other site 191026013162 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 191026013163 AAA ATPase domain; Region: AAA_16; pfam13191 191026013164 Predicted ATPase [General function prediction only]; Region: COG3899 191026013165 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 191026013166 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 191026013167 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 191026013168 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 191026013169 putative active site [active] 191026013170 heme pocket [chemical binding]; other site 191026013171 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 191026013172 dimer interface [polypeptide binding]; other site 191026013173 phosphorylation site [posttranslational modification] 191026013174 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 191026013175 ATP binding site [chemical binding]; other site 191026013176 Mg2+ binding site [ion binding]; other site 191026013177 G-X-G motif; other site 191026013178 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 191026013179 Response regulator receiver domain; Region: Response_reg; pfam00072 191026013180 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 191026013181 active site 191026013182 phosphorylation site [posttranslational modification] 191026013183 intermolecular recognition site; other site 191026013184 dimerization interface [polypeptide binding]; other site 191026013185 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 191026013186 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 191026013187 G1 box; other site 191026013188 putative GEF interaction site [polypeptide binding]; other site 191026013189 GTP/Mg2+ binding site [chemical binding]; other site 191026013190 Switch I region; other site 191026013191 G2 box; other site 191026013192 G3 box; other site 191026013193 Switch II region; other site 191026013194 G4 box; other site 191026013195 G5 box; other site 191026013196 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 191026013197 DEDDy 3'-5' exonuclease domain of WRN and similar proteins; Region: WRN_exo; cd06141 191026013198 catalytic site [active] 191026013199 putative active site [active] 191026013200 putative substrate binding site [chemical binding]; other site 191026013201 Uncharacterized protein conserved in archaea [Function unknown]; Region: COG3366 191026013202 Nucleoside recognition; Region: Gate; pfam07670 191026013203 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 191026013204 oligomerization interface [polypeptide binding]; other site 191026013205 active site 191026013206 metal binding site [ion binding]; metal-binding site 191026013207 Bacteriophage CI repressor helix-turn-helix domain; Region: Phage_CI_repr; pfam07022 191026013208 The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cd06462 191026013209 Catalytic site [active] 191026013210 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 191026013211 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 191026013212 ATP binding site [chemical binding]; other site 191026013213 Mg2+ binding site [ion binding]; other site 191026013214 G-X-G motif; other site 191026013215 CT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_1; cd04870 191026013216 ACT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_2; cd04871 191026013217 phosphoserine phosphatase SerB; Region: serB; TIGR00338 191026013218 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 191026013219 motif II; other site 191026013220 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 191026013221 PAS fold; Region: PAS_3; pfam08447 191026013222 putative active site [active] 191026013223 heme pocket [chemical binding]; other site 191026013224 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 191026013225 PAS domain; Region: PAS_9; pfam13426 191026013226 putative active site [active] 191026013227 heme pocket [chemical binding]; other site 191026013228 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 191026013229 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 191026013230 metal binding site [ion binding]; metal-binding site 191026013231 active site 191026013232 I-site; other site 191026013233 Domain of unknown function (DUF4198); Region: DUF4198; pfam10670 191026013234 Ferrous iron transport protein B; Region: FeoB_N; pfam02421 191026013235 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 191026013236 G1 box; other site 191026013237 GTP/Mg2+ binding site [chemical binding]; other site 191026013238 Switch I region; other site 191026013239 G2 box; other site 191026013240 G3 box; other site 191026013241 Switch II region; other site 191026013242 G4 box; other site 191026013243 G5 box; other site 191026013244 Nucleoside recognition; Region: Gate; pfam07670 191026013245 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 191026013246 Nucleoside recognition; Region: Gate; pfam07670 191026013247 FeoA domain; Region: FeoA; pfam04023 191026013248 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 191026013249 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 191026013250 metal binding site [ion binding]; metal-binding site 191026013251 active site 191026013252 I-site; other site 191026013253 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 191026013254 metal binding site 2 [ion binding]; metal-binding site 191026013255 putative DNA binding helix; other site 191026013256 metal binding site 1 [ion binding]; metal-binding site 191026013257 dimer interface [polypeptide binding]; other site 191026013258 structural Zn2+ binding site [ion binding]; other site 191026013259 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 191026013260 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 191026013261 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 191026013262 motif II; other site 191026013263 Domain of unknown function (DUF4405); Region: DUF4405; pfam14358 191026013264 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 191026013265 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 191026013266 Soluble P-type ATPase [General function prediction only]; Region: COG4087 191026013267 FeoA domain; Region: FeoA; pfam04023 191026013268 FeoA domain; Region: FeoA; pfam04023 191026013269 FeoA domain; Region: FeoA; cl00838 191026013270 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14460 191026013271 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 191026013272 FeS/SAM binding site; other site 191026013273 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 191026013274 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 191026013275 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 191026013276 dimerization interface [polypeptide binding]; other site 191026013277 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 191026013278 PAS domain; Region: PAS; smart00091 191026013279 putative active site [active] 191026013280 heme pocket [chemical binding]; other site 191026013281 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 191026013282 dimer interface [polypeptide binding]; other site 191026013283 phosphorylation site [posttranslational modification] 191026013284 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 191026013285 ATP binding site [chemical binding]; other site 191026013286 Mg2+ binding site [ion binding]; other site 191026013287 G-X-G motif; other site 191026013288 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 191026013289 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 191026013290 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 191026013291 acetyl-CoA synthetase; Provisional; Region: PRK00174 191026013292 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 191026013293 active site 191026013294 CoA binding site [chemical binding]; other site 191026013295 acyl-activating enzyme (AAE) consensus motif; other site 191026013296 AMP binding site [chemical binding]; other site 191026013297 acetate binding site [chemical binding]; other site 191026013298 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 191026013299 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 191026013300 active site 191026013301 phosphorylation site [posttranslational modification] 191026013302 intermolecular recognition site; other site 191026013303 dimerization interface [polypeptide binding]; other site 191026013304 LytTr DNA-binding domain; Region: LytTR; smart00850 191026013305 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 191026013306 metal binding site 2 [ion binding]; metal-binding site 191026013307 putative DNA binding helix; other site 191026013308 metal binding site 1 [ion binding]; metal-binding site 191026013309 dimer interface [polypeptide binding]; other site 191026013310 structural Zn2+ binding site [ion binding]; other site 191026013311 Rubrerythrin [Energy production and conversion]; Region: COG1592 191026013312 Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041 191026013313 binuclear metal center [ion binding]; other site 191026013314 Rubredoxin_like; nonheme iron binding domain containing a [Fe(SCys)4] center. The family includes rubredoxins, a small electron transfer protein, and a slightly smaller modular rubredoxin domain present in rubrerythrin and nigerythrin and detected either...; Region: rubredoxin_like; cl00202 191026013315 iron binding site [ion binding]; other site 191026013316 desulfoferrodoxin; Region: dfx_rbo; TIGR00320 191026013317 Desulforedoxin (DSRD) domain; a small non-heme iron domain present in the desulforedoxin (rubredoxin oxidoreductase) and desulfoferrodoxin proteins of some archeael and bacterial methanogens and sulfate/sulfur reducers. Desulforedoxin is a small; Region: DSRD; cd00974 191026013318 non-heme iron binding site [ion binding]; other site 191026013319 dimer interface [polypeptide binding]; other site 191026013320 Superoxide reductase-like (SORL) domain, class I; SORL-domains are present in a family of mononuclear non-heme iron proteins that includes superoxide reductase and desulfoferrodoxin. Superoxide reductase-like proteins scavenge superoxide anion radicals...; Region: SORL_Dfx_classI; cd03171 191026013321 non-heme iron binding site [ion binding]; other site 191026013322 dimer interface [polypeptide binding]; other site 191026013323 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 11123953, 11751865, 12101220, 12142437, 12529359, 12586421, 20573621, 9660187; Product type c : carrier 191026013324 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 11123953, 11751865, 12101220, 12142437, 12529359, 12586421, 20573621, 9660187; Product type c : carrier 191026013325 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 11123953, 11751865, 12101220, 12142437, 12529359, 12586421, 20573621, 9660187; Product type c : carrier 191026013326 HEAT-like repeat; Region: HEAT_EZ; pfam13513 191026013327 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 191026013328 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 191026013329 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 191026013330 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 191026013331 Ferritin-like domain; Region: Ferritin; pfam00210 191026013332 ferroxidase diiron center [ion binding]; other site 191026013333 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 191026013334 dimerization interface [polypeptide binding]; other site 191026013335 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 191026013336 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 191026013337 putative active site [active] 191026013338 heme pocket [chemical binding]; other site 191026013339 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 191026013340 dimer interface [polypeptide binding]; other site 191026013341 phosphorylation site [posttranslational modification] 191026013342 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 191026013343 ATP binding site [chemical binding]; other site 191026013344 Mg2+ binding site [ion binding]; other site 191026013345 G-X-G motif; other site 191026013346 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_1; cd03169 191026013347 intracellular protease, PfpI family; Region: PfpI; TIGR01382 191026013348 conserved cys residue [active] 191026013349 Ribbon-helix-helix domain; Region: RHH_4; pfam13467 191026013350 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 191026013351 Metal binding protein HemV-2. These proteins are predicted to function as initial receptors in ABC transport of metal ions. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and ligand binding...; Region: HemV-2; cd01147 191026013352 putative metal binding site [ion binding]; other site 191026013353 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 191026013354 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 191026013355 ABC-ATPase subunit interface; other site 191026013356 dimer interface [polypeptide binding]; other site 191026013357 putative PBP binding regions; other site 191026013358 phosphonate ABC transporter, ATP-binding protein; Region: ABC_phnC; TIGR02315 191026013359 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 191026013360 Walker A/P-loop; other site 191026013361 ATP binding site [chemical binding]; other site 191026013362 Q-loop/lid; other site 191026013363 ABC transporter signature motif; other site 191026013364 Walker B; other site 191026013365 D-loop; other site 191026013366 H-loop/switch region; other site 191026013367 Formylmethanofuran dehydrogenase subunit E [Energy production and conversion]; Region: COG2191 191026013368 FmdE, Molybdenum formylmethanofuran dehydrogenase operon; Region: FmdE; pfam02663 191026013369 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; pfam01258 191026013370 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 191026013371 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 191026013372 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 191026013373 ligand binding site [chemical binding]; other site 191026013374 hypothetical protein; Provisional; Region: PRK09256 191026013375 This uncharacterized conserved protein belongs to a family of iron-molybdenum cluster-binding proteins that includes NifX, NifB, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of...; Region: MTH1175; cd00851 191026013376 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3012 191026013377 SEC-C motif; Region: SEC-C; pfam02810 191026013378 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cl00197 191026013379 active site 191026013380 Hemerythrin; Region: Hemerythrin; cd12107 191026013381 Fe binding site [ion binding]; other site 191026013382 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 191026013383 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 191026013384 putative dimer interface [polypeptide binding]; other site 191026013385 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 191026013386 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 191026013387 putative dimer interface [polypeptide binding]; other site 191026013388 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 191026013389 FKBP-type peptidyl-prolyl cis-trans isomerases 2 [Posttranslational modification, protein turnover, chaperones]; Region: SlpA; COG1047 191026013390 Trm112p-like protein; Region: Trm112p; cl01066 191026013391 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 191026013392 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 191026013393 active site 191026013394 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 191026013395 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 191026013396 Peptidase family U32; Region: Peptidase_U32; pfam01136 191026013397 FOG: CBS domain [General function prediction only]; Region: COG0517 191026013398 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the acetoin utilization proteins in bacteria. Acetoin is a product of fermentative metabolism in many prokaryotic and eukaryotic microorganisms. They produce...; Region: CBS_pair_ACT_assoc2; cd04585 191026013399 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 191026013400 Protein of unknown function (DUF2959); Region: DUF2959; pfam11172 191026013401 Helix-turn-helix domain; Region: HTH_17; pfam12728 191026013402 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 191026013403 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 191026013404 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 191026013405 ABC-type thiamine transport system, ATPase component [Coenzyme metabolism]; Region: ThiQ; COG3840 191026013406 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 191026013407 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 191026013408 active site 191026013409 metal binding site [ion binding]; metal-binding site 191026013410 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 191026013411 AAA domain; Region: AAA_23; pfam13476 191026013412 Walker A/P-loop; other site 191026013413 ATP binding site [chemical binding]; other site 191026013414 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 191026013415 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 191026013416 S-adenosylmethionine binding site [chemical binding]; other site 191026013417 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 191026013418 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 191026013419 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 191026013420 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 191026013421 DNA binding site [nucleotide binding] 191026013422 catalytic residue [active] 191026013423 H2TH interface [polypeptide binding]; other site 191026013424 putative catalytic residues [active] 191026013425 turnover-facilitating residue; other site 191026013426 intercalation triad [nucleotide binding]; other site 191026013427 8OG recognition residue [nucleotide binding]; other site 191026013428 putative reading head residues; other site 191026013429 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 191026013430 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 191026013431 Protein of unknown function, DUF399; Region: DUF399; pfam04187 191026013432 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 191026013433 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 191026013434 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 191026013435 acyl-activating enzyme (AAE) consensus motif; other site 191026013436 AMP binding site [chemical binding]; other site 191026013437 active site 191026013438 CoA binding site [chemical binding]; other site 191026013439 Cache domain; Region: Cache_1; pfam02743 191026013440 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 191026013441 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 191026013442 dimerization interface [polypeptide binding]; other site 191026013443 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 191026013444 dimer interface [polypeptide binding]; other site 191026013445 putative CheW interface [polypeptide binding]; other site 191026013446 Transcriptional regulators [Transcription]; Region: FadR; COG2186 191026013447 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 191026013448 DNA-binding site [nucleotide binding]; DNA binding site 191026013449 FCD domain; Region: FCD; pfam07729 191026013450 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 191026013451 fructuronate transporter; Provisional; Region: PRK10034; cl15264 191026013452 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 191026013453 TPR motif; other site 191026013454 binding surface 191026013455 Domain of unknown function (DUF4147); Region: DUF4147; pfam13660 191026013456 Putative glycerate kinase [Carbohydrate transport and metabolism]; Region: GckA; COG2379 191026013457 MOFRL family; Region: MOFRL; pfam05161 191026013458 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 191026013459 PAS domain; Region: PAS_9; pfam13426 191026013460 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 191026013461 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 191026013462 dimer interface [polypeptide binding]; other site 191026013463 putative CheW interface [polypeptide binding]; other site 191026013464 Amidohydrolase; Region: Amidohydro_2; pfam04909 191026013465 Surface antigen [Cell envelope biogenesis, outer membrane]; Region: LipA; COG4520 191026013466 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 191026013467 S-adenosylmethionine binding site [chemical binding]; other site 191026013468 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 191026013469 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 191026013470 dimer interface [polypeptide binding]; other site 191026013471 decamer (pentamer of dimers) interface [polypeptide binding]; other site 191026013472 catalytic triad [active] 191026013473 peroxidatic and resolving cysteines [active] 191026013474 Predicted Zn-dependent peptidases, insulinase-like [General function prediction only]; Region: COG1026 191026013475 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 191026013476 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 191026013477 Peptidase M16C associated; Region: M16C_assoc; pfam08367 191026013478 exosortase A system-associated amidotransferase 1; Region: eps_aminotran_1; TIGR03108 191026013479 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 191026013480 active site 191026013481 dimer interface [polypeptide binding]; other site 191026013482 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 191026013483 Ligand Binding Site [chemical binding]; other site 191026013484 Molecular Tunnel; other site 191026013485 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 191026013486 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 191026013487 putative ADP-binding pocket [chemical binding]; other site 191026013488 Escherichia coli YdjC-like family of proteins; Region: YdjC; cd10808 191026013489 putative active site [active] 191026013490 YdjC motif; other site 191026013491 Mg binding site [ion binding]; other site 191026013492 putative homodimer interface [polypeptide binding]; other site 191026013493 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 191026013494 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 191026013495 Ligand binding site; other site 191026013496 Putative Catalytic site; other site 191026013497 DXD motif; other site 191026013498 flagellar motor protein MotS; Reviewed; Region: PRK06925 191026013499 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 191026013500 ligand binding site [chemical binding]; other site 191026013501 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 191026013502 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 191026013503 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 191026013504 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 191026013505 ligand binding site [chemical binding]; other site 191026013506 flexible hinge region; other site 191026013507 FliG C-terminal domain; Region: FliG_C; pfam01706 191026013508 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 191026013509 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 191026013510 Putative catalytic domain, repeat 1, of uncharacterized proteins similar to bacterial cardiolipin synthase; Region: PLDc_CLS_unchar1_1; cd09156 191026013511 putative active site [active] 191026013512 catalytic site [active] 191026013513 Putative catalytic domain, repeat 2, of uncharacterized proteins similar to bacterial cardiolipin synthase; Region: PLDc_CLS_unchar1_2; cd09162 191026013514 putative active site [active] 191026013515 catalytic site [active] 191026013516 Zinc dependent phospholipase C; Region: Zn_dep_PLPC; pfam00882 191026013517 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 191026013518 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 191026013519 tandem repeat interface [polypeptide binding]; other site 191026013520 oligomer interface [polypeptide binding]; other site 191026013521 active site residues [active] 191026013522 chlorohydrolase; Provisional; Region: PRK08418 191026013523 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 191026013524 active site 191026013525 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 191026013526 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 191026013527 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 191026013528 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 191026013529 dihydroorotase; Validated; Region: pyrC; PRK09357 191026013530 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 191026013531 active site 191026013532 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 191026013533 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 191026013534 Zn2+ binding site [ion binding]; other site 191026013535 Mg2+ binding site [ion binding]; other site 191026013536 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 191026013537 diphosphate--fructose-6-phosphate 1-phosphotransferase; Provisional; Region: PRK06830 191026013538 6-phosphofructokinase; Region: PLN02884 191026013539 active site 191026013540 ADP/pyrophosphate binding site [chemical binding]; other site 191026013541 dimerization interface [polypeptide binding]; other site 191026013542 allosteric effector site; other site 191026013543 fructose-1,6-bisphosphate binding site; other site 191026013544 Domain of unknown function (DUF1992); Region: DUF1992; cl08096 191026013545 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 191026013546 mce related protein; Region: MCE; pfam02470 191026013547 MbeD/MobD like; Region: MbeD_MobD; pfam04899 191026013548 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 191026013549 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 191026013550 Walker A/P-loop; other site 191026013551 ATP binding site [chemical binding]; other site 191026013552 Q-loop/lid; other site 191026013553 ABC transporter signature motif; other site 191026013554 Walker B; other site 191026013555 D-loop; other site 191026013556 H-loop/switch region; other site 191026013557 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 191026013558 Permease; Region: Permease; pfam02405 191026013559 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 191026013560 anti sigma factor interaction site; other site 191026013561 regulatory phosphorylation site [posttranslational modification]; other site 191026013562 GAF domain; Region: GAF; pfam01590 191026013563 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 191026013564 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 191026013565 ADP-heptose synthase, bifunctional sugar kinase/adenylyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaE; COG2870 191026013566 RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172 191026013567 putative ribose interaction site [chemical binding]; other site 191026013568 putative ADP binding site [chemical binding]; other site 191026013569 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 191026013570 ParB-like nuclease domain; Region: ParB; smart00470 191026013571 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 191026013572 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 191026013573 P-loop; other site 191026013574 Magnesium ion binding site [ion binding]; other site 191026013575 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 191026013576 Magnesium ion binding site [ion binding]; other site 191026013577 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 191026013578 UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253 191026013579 putative NAD(P) binding site [chemical binding]; other site 191026013580 active site 191026013581 putative substrate binding site [chemical binding]; other site 191026013582 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 191026013583 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 191026013584 Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030 191026013585 Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763 191026013586 active site 191026013587 NfeD-like C-terminal, partner-binding; Region: NfeD; pfam01957 191026013588 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 191026013589 Flavoprotein; Region: Flavoprotein; pfam02441 191026013590 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 191026013591 V-type ATP synthase subunit I; Validated; Region: PRK05771 191026013592 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 191026013593 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 191026013594 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 191026013595 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 191026013596 2-ketoisovalerate ferredoxin reductase; Validated; Region: PRK07119 191026013597 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 191026013598 dimer interface [polypeptide binding]; other site 191026013599 PYR/PP interface [polypeptide binding]; other site 191026013600 TPP binding site [chemical binding]; other site 191026013601 substrate binding site [chemical binding]; other site 191026013602 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, beta subunit [Energy production and conversion]; Region: PorB; COG1013 191026013603 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 191026013604 TPP-binding site [chemical binding]; other site 191026013605 2-oxoglutarate ferredoxin oxidoreductase subunit gamma; Validated; Region: PRK08537 191026013606 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; pfam01558 191026013607 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 191026013608 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 191026013609 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 191026013610 shikimate binding site; other site 191026013611 NAD(P) binding site [chemical binding]; other site 191026013612 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 191026013613 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 191026013614 NAD(P) binding site [chemical binding]; other site 191026013615 catalytic residues [active] 191026013616 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 191026013617 N-acetyl-D-glucosamine binding site [chemical binding]; other site 191026013618 catalytic residue [active] 191026013619 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 191026013620 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 191026013621 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 191026013622 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 191026013623 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 191026013624 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 191026013625 flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700 191026013626 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 191026013627 Flagellar biosynthesis protein, FliO; Region: FliO; pfam04347 191026013628 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 191026013629 Flagellar basal body-associated protein FliL; Region: FliL; pfam03748 191026013630 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 191026013631 ligand binding site [chemical binding]; other site 191026013632 Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360 191026013633 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 191026013634 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 191026013635 ligand binding site [chemical binding]; other site 191026013636 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 191026013637 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 191026013638 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 191026013639 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 191026013640 catalytic residue [active] 191026013641 GTPase Era; Reviewed; Region: era; PRK00089 191026013642 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 191026013643 G1 box; other site 191026013644 GTP/Mg2+ binding site [chemical binding]; other site 191026013645 Switch I region; other site 191026013646 G2 box; other site 191026013647 Switch II region; other site 191026013648 G3 box; other site 191026013649 G4 box; other site 191026013650 G5 box; other site 191026013651 KH domain; Region: KH_2; pfam07650 191026013652 G-X-X-G motif; other site 191026013653 DNA topoisomerase I; Validated; Region: PRK06599 191026013654 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 191026013655 active site 191026013656 interdomain interaction site; other site 191026013657 putative metal-binding site [ion binding]; other site 191026013658 nucleotide binding site [chemical binding]; other site 191026013659 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 191026013660 domain I; other site 191026013661 DNA binding groove [nucleotide binding] 191026013662 phosphate binding site [ion binding]; other site 191026013663 domain II; other site 191026013664 domain III; other site 191026013665 nucleotide binding site [chemical binding]; other site 191026013666 catalytic site [active] 191026013667 domain IV; other site 191026013668 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 191026013669 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 191026013670 Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551 191026013671 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 191026013672 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 191026013673 Hpt domain; Region: Hpt; pfam01627 191026013674 putative binding surface; other site 191026013675 active site 191026013676 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 191026013677 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 191026013678 Protein export membrane protein; Region: SecD_SecF; cl14618 191026013679 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 191026013680 HlyD family secretion protein; Region: HlyD_3; pfam13437 191026013681 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 191026013682 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 191026013683 WHG domain; Region: WHG; pfam13305 191026013684 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 191026013685 Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437 191026013686 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 191026013687 active site 191026013688 phosphorylation site [posttranslational modification] 191026013689 intermolecular recognition site; other site 191026013690 dimerization interface [polypeptide binding]; other site 191026013691 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 191026013692 Zn2+ binding site [ion binding]; other site 191026013693 Mg2+ binding site [ion binding]; other site 191026013694 CHASE domain; Region: CHASE; cl01369 191026013695 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 191026013696 PAS fold; Region: PAS_3; pfam08447 191026013697 putative active site [active] 191026013698 heme pocket [chemical binding]; other site 191026013699 PAS domain S-box; Region: sensory_box; TIGR00229 191026013700 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 191026013701 PAS domain; Region: PAS_9; pfam13426 191026013702 putative active site [active] 191026013703 heme pocket [chemical binding]; other site 191026013704 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 191026013705 His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512 191026013706 dimer interface [polypeptide binding]; other site 191026013707 phosphorylation site [posttranslational modification] 191026013708 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 191026013709 ATP binding site [chemical binding]; other site 191026013710 Mg2+ binding site [ion binding]; other site 191026013711 G-X-G motif; other site 191026013712 Protein of unknown function (DUF3431); Region: DUF3431; pfam11913 191026013713 pH-dependent sodium/proton antiporter; Reviewed; Region: nhaA; PRK09560 191026013714 ferric uptake regulator; Provisional; Region: fur; PRK09462 191026013715 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 191026013716 metal binding site 2 [ion binding]; metal-binding site 191026013717 putative DNA binding helix; other site 191026013718 metal binding site 1 [ion binding]; metal-binding site 191026013719 dimer interface [polypeptide binding]; other site 191026013720 structural Zn2+ binding site [ion binding]; other site 191026013721 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 191026013722 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 191026013723 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 191026013724 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 191026013725 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 191026013726 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 191026013727 molybdopterin cofactor binding site; other site 191026013728 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cd02775 191026013729 molybdopterin cofactor binding site; other site 191026013730 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 191026013731 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 191026013732 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 191026013733 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 191026013734 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 191026013735 intersubunit interface [polypeptide binding]; other site 191026013736 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 191026013737 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 191026013738 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 191026013739 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 191026013740 ABC-ATPase subunit interface; other site 191026013741 dimer interface [polypeptide binding]; other site 191026013742 putative PBP binding regions; other site 191026013743 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 191026013744 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 191026013745 intersubunit interface [polypeptide binding]; other site 191026013746 Tetratricopeptide repeat; Region: TPR_12; pfam13424 191026013747 DNA gyrase subunit A; Validated; Region: PRK05560 191026013748 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 191026013749 CAP-like domain; other site 191026013750 active site 191026013751 primary dimer interface [polypeptide binding]; other site 191026013752 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 191026013753 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 191026013754 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 191026013755 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 191026013756 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 191026013757 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 191026013758 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 191026013759 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 191026013760 ATP binding site [chemical binding]; other site 191026013761 Mg2+ binding site [ion binding]; other site 191026013762 G-X-G motif; other site 191026013763 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 191026013764 anchoring element; other site 191026013765 dimer interface [polypeptide binding]; other site 191026013766 ATP binding site [chemical binding]; other site 191026013767 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 191026013768 active site 191026013769 putative metal-binding site [ion binding]; other site 191026013770 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 191026013771 DNA polymerase III subunit beta; Provisional; Region: PRK14947 191026013772 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 191026013773 putative DNA binding surface [nucleotide binding]; other site 191026013774 dimer interface [polypeptide binding]; other site 191026013775 beta-clamp/clamp loader binding surface; other site 191026013776 beta-clamp/translesion DNA polymerase binding surface; other site 191026013777 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 191026013778 DnaA N-terminal domain; Region: DnaA_N; pfam11638 191026013779 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 191026013780 Walker A motif; other site 191026013781 ATP binding site [chemical binding]; other site 191026013782 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 191026013783 DnaA box-binding interface [nucleotide binding]; other site 191026013784 Domain of unknown function DUF39; Region: DUF39; pfam01837 191026013785 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 191026013786 EamA-like transporter family; Region: EamA; pfam00892 191026013787 EamA-like transporter family; Region: EamA; pfam00892 191026013788 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 191026013789 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 191026013790 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 191026013791 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 191026013792 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 191026013793 motif II; other site 191026013794 Uncharacterized Fe-S center protein [General function prediction only]; Region: COG2768 191026013795 Uncharacterized conserved protein [Function unknown]; Region: COG2006 191026013796 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 191026013797 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 191026013798 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 191026013799 FtsX-like permease family; Region: FtsX; pfam02687 191026013800 cell division ATP-binding protein FtsE; Region: FtsE; TIGR02673 191026013801 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 191026013802 Walker A/P-loop; other site 191026013803 ATP binding site [chemical binding]; other site 191026013804 Q-loop/lid; other site 191026013805 ABC transporter signature motif; other site 191026013806 Walker B; other site 191026013807 D-loop; other site 191026013808 H-loop/switch region; other site 191026013809 aspartate aminotransferase; Provisional; Region: PRK05764 191026013810 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 191026013811 pyridoxal 5'-phosphate binding site [chemical binding]; other site 191026013812 homodimer interface [polypeptide binding]; other site 191026013813 catalytic residue [active] 191026013814 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 191026013815 dimer interface [polypeptide binding]; other site 191026013816 active site 191026013817 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 191026013818 dimer interface [polypeptide binding]; other site 191026013819 active site 191026013820 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 191026013821 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 191026013822 dimer interface [polypeptide binding]; other site 191026013823 phosphorylation site [posttranslational modification] 191026013824 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 191026013825 ATP binding site [chemical binding]; other site 191026013826 Mg2+ binding site [ion binding]; other site 191026013827 G-X-G motif; other site 191026013828 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 191026013829 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 191026013830 active site 191026013831 phosphorylation site [posttranslational modification] 191026013832 intermolecular recognition site; other site 191026013833 dimerization interface [polypeptide binding]; other site 191026013834 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 191026013835 Walker A motif; other site 191026013836 ATP binding site [chemical binding]; other site 191026013837 Walker B motif; other site 191026013838 arginine finger; other site 191026013839 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 191026013840 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 191026013841 Aldehyde:ferredoxin oxidoreductase [Energy production and conversion]; Region: COG2414 191026013842 Aldehyde ferredoxin oxidoreductase, N-terminal domain; Region: AFOR_N; smart00790 191026013843 Aldehyde ferredoxin oxidoreductase, domains 2 & 3; Region: AFOR_C; pfam01314 191026013844 HAMP domain; Region: HAMP; pfam00672 191026013845 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 191026013846 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 191026013847 dimer interface [polypeptide binding]; other site 191026013848 putative CheW interface [polypeptide binding]; other site 191026013849 S-ribosylhomocysteinase; Provisional; Region: PRK02260 191026013850 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 191026013851 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 191026013852 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 191026013853 dimerization interface [polypeptide binding]; other site 191026013854 Transcriptional regulator [Transcription]; Region: LysR; COG0583 191026013855 putative DNA binding site [nucleotide binding]; other site 191026013856 putative Zn2+ binding site [ion binding]; other site 191026013857 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 191026013858 dimerization interface [polypeptide binding]; other site 191026013859 Glycerophosphodiester phosphodiesterase domain similar to Escherichia coli periplasmic phosphodiesterase (GlpQ) include uncharacterized proteins; Region: GDPD_EcGlpQ_like_1; cd08560 191026013860 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 191026013861 putative active site [active] 191026013862 catalytic site [active] 191026013863 putative metal binding site [ion binding]; other site 191026013864 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 191026013865 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 191026013866 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 191026013867 DNA-binding site [nucleotide binding]; DNA binding site 191026013868 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 191026013869 pyridoxal 5'-phosphate binding site [chemical binding]; other site 191026013870 homodimer interface [polypeptide binding]; other site 191026013871 catalytic residue [active] 191026013872 4Fe-4S binding domain; Region: Fer4; pfam00037 191026013873 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 191026013874 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 191026013875 GAF domain; Region: GAF; pfam01590 191026013876 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 191026013877 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 191026013878 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 191026013879 Glutaredoxin-like domain protein; Region: GlrX_arch; TIGR02187 191026013880 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 191026013881 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 191026013882 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 191026013883 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 191026013884 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 191026013885 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 191026013886 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 191026013887 FeS/SAM binding site; other site 191026013888 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 191026013889 HIT family signature motif; other site 191026013890 catalytic residue [active] 191026013891 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 191026013892 IHF - DNA interface [nucleotide binding]; other site 191026013893 IHF dimer interface [polypeptide binding]; other site 191026013894 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 191026013895 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 191026013896 Sporulation related domain; Region: SPOR; pfam05036 191026013897 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 191026013898 AAA domain; Region: AAA_32; pfam13654 191026013899 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 191026013900 Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; pfam09527 191026013901 ATP synthase I chain; Region: ATP_synt_I; pfam03899 191026013902 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 191026013903 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 191026013904 ATP synthase subunit C; Region: ATP-synt_C; cl00466 191026013905 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 191026013906 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 191026013907 CoA binding domain; Region: CoA_binding; pfam02629 191026013908 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 191026013909 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 191026013910 active site 191026013911 phosphorylation site [posttranslational modification] 191026013912 intermolecular recognition site; other site 191026013913 dimerization interface [polypeptide binding]; other site 191026013914 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 191026013915 Walker A motif; other site 191026013916 ATP binding site [chemical binding]; other site 191026013917 Walker B motif; other site 191026013918 arginine finger; other site 191026013919 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 191026013920 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 191026013921 Major Facilitator Superfamily; Region: MFS_1; pfam07690 191026013922 putative substrate translocation pore; other site 191026013923 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 191026013924 putative substrate translocation pore; other site 191026013925 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; cl17726 191026013926 alkyl hydroperoxide reductase subunit F; Region: AhpF; TIGR03140 191026013927 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 191026013928 Predicted phosphoesterases, related to the Icc protein [General function prediction only]; Region: COG2129 191026013929 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 191026013930 active site 191026013931 metal binding site [ion binding]; metal-binding site 191026013932 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 191026013933 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 191026013934 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 191026013935 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 191026013936 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 191026013937 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 191026013938 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 191026013939 active site 191026013940 phosphorylation site [posttranslational modification] 191026013941 intermolecular recognition site; other site 191026013942 dimerization interface [polypeptide binding]; other site 191026013943 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 191026013944 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 191026013945 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 191026013946 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 191026013947 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 191026013948 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 191026013949 metal binding site [ion binding]; metal-binding site 191026013950 active site 191026013951 I-site; other site 191026013952 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 191026013953 dimerization interface [polypeptide binding]; other site 191026013954 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 191026013955 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 191026013956 dimer interface [polypeptide binding]; other site 191026013957 phosphorylation site [posttranslational modification] 191026013958 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 191026013959 ATP binding site [chemical binding]; other site 191026013960 Mg2+ binding site [ion binding]; other site 191026013961 G-X-G motif; other site 191026013962 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 191026013963 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 191026013964 active site 191026013965 phosphorylation site [posttranslational modification] 191026013966 intermolecular recognition site; other site 191026013967 dimerization interface [polypeptide binding]; other site 191026013968 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 191026013969 DNA binding site [nucleotide binding] 191026013970 Protein of unknown function (DUF3365); Region: DUF3365; pfam11845 191026013971 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 191026013972 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 191026013973 dimer interface [polypeptide binding]; other site 191026013974 putative CheW interface [polypeptide binding]; other site 191026013975 Response regulator receiver domain; Region: Response_reg; pfam00072 191026013976 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 191026013977 active site 191026013978 phosphorylation site [posttranslational modification] 191026013979 intermolecular recognition site; other site 191026013980 dimerization interface [polypeptide binding]; other site 191026013981 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 191026013982 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 191026013983 chemotaxis-specific methylesterase; Provisional; Region: PRK12555 191026013984 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 191026013985 active site 191026013986 phosphorylation site [posttranslational modification] 191026013987 intermolecular recognition site; other site 191026013988 CheB methylesterase; Region: CheB_methylest; pfam01339 191026013989 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 191026013990 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 191026013991 putative binding surface; other site 191026013992 active site 191026013993 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 191026013994 putative binding surface; other site 191026013995 active site 191026013996 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 191026013997 ATP binding site [chemical binding]; other site 191026013998 Mg2+ binding site [ion binding]; other site 191026013999 G-X-G motif; other site 191026014000 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 191026014001 Response regulator receiver domain; Region: Response_reg; pfam00072 191026014002 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 191026014003 active site 191026014004 phosphorylation site [posttranslational modification] 191026014005 intermolecular recognition site; other site 191026014006 dimerization interface [polypeptide binding]; other site 191026014007 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cd00588 191026014008 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 191026014009 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 191026014010 S-adenosylmethionine binding site [chemical binding]; other site 191026014011 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 191026014012 binding surface 191026014013 TPR motif; other site 191026014014 TPR repeat; Region: TPR_11; pfam13414 191026014015 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 191026014016 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 191026014017 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 191026014018 dimer interface [polypeptide binding]; other site 191026014019 putative CheW interface [polypeptide binding]; other site 191026014020 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 191026014021 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 191026014022 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 191026014023 conserved hypothetical integral membrane protein; Region: TIGR00697 191026014024 Sporulation related domain; Region: SPOR; pfam05036 191026014025 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 191026014026 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 191026014027 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 191026014028 active site 191026014029 HIGH motif; other site 191026014030 KMSK motif region; other site 191026014031 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 191026014032 tRNA binding surface [nucleotide binding]; other site 191026014033 anticodon binding site; other site 191026014034 S-adenosyl-l-methionine hydroxide adenosyltransferase; Region: SAM_adeno_trans; pfam01887 191026014035 cobalamin synthase; Reviewed; Region: cobS; PRK00235 191026014036 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 191026014037 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 191026014038 phosphorylation site [posttranslational modification] 191026014039 dimer interface [polypeptide binding]; other site 191026014040 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 191026014041 ATP binding site [chemical binding]; other site 191026014042 Mg2+ binding site [ion binding]; other site 191026014043 G-X-G motif; other site 191026014044 Cache domain; Region: Cache_2; cl07034 191026014045 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 191026014046 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 191026014047 dimerization interface [polypeptide binding]; other site 191026014048 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 191026014049 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 191026014050 putative active site [active] 191026014051 heme pocket [chemical binding]; other site 191026014052 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 191026014053 dimer interface [polypeptide binding]; other site 191026014054 phosphorylation site [posttranslational modification] 191026014055 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 191026014056 ATP binding site [chemical binding]; other site 191026014057 Mg2+ binding site [ion binding]; other site 191026014058 G-X-G motif; other site 191026014059 acetyl-CoA synthetase; Provisional; Region: PRK00174 191026014060 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 191026014061 active site 191026014062 CoA binding site [chemical binding]; other site 191026014063 acyl-activating enzyme (AAE) consensus motif; other site 191026014064 AMP binding site [chemical binding]; other site 191026014065 acetate binding site [chemical binding]; other site 191026014066 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 191026014067 CoA binding domain; Region: CoA_binding_2; pfam13380 191026014068 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 191026014069 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 191026014070 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 191026014071 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 191026014072 Uncharacterized protein conserved in archaea (DUF2139); Region: DUF2139; cl01925 191026014073 helicase/secretion neighborhood putative DEAH-box helicase; Region: DECH_helic; TIGR03817 191026014074 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 191026014075 ATP binding site [chemical binding]; other site 191026014076 putative Mg++ binding site [ion binding]; other site 191026014077 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 191026014078 nucleotide binding region [chemical binding]; other site 191026014079 ATP-binding site [chemical binding]; other site 191026014080 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 191026014081 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 191026014082 active site 191026014083 substrate binding site [chemical binding]; other site 191026014084 catalytic site [active] 191026014085 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 191026014086 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 191026014087 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 191026014088 serine/threonine transporter SstT; Provisional; Region: PRK13628 191026014089 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 191026014090 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA; cl00391 191026014091 active site clefts [active] 191026014092 zinc binding site [ion binding]; other site 191026014093 dimer interface [polypeptide binding]; other site 191026014094 Peptidase family C69; Region: Peptidase_C69; cl17793 191026014095 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 191026014096 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 191026014097 Response regulator receiver domain; Region: Response_reg; pfam00072 191026014098 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 191026014099 active site 191026014100 phosphorylation site [posttranslational modification] 191026014101 intermolecular recognition site; other site 191026014102 dimerization interface [polypeptide binding]; other site 191026014103 uncharacterized bacterial and archaeal solute carrier 6 subfamily; solute-binding domain; Region: SLC6sbd_u1; cd10334 191026014104 Na2 binding site [ion binding]; other site 191026014105 putative substrate binding site 1 [chemical binding]; other site 191026014106 Na binding site 1 [ion binding]; other site 191026014107 putative substrate binding site 2 [chemical binding]; other site 191026014108 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 191026014109 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 191026014110 active site 191026014111 phosphorylation site [posttranslational modification] 191026014112 intermolecular recognition site; other site 191026014113 dimerization interface [polypeptide binding]; other site 191026014114 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 191026014115 Walker A motif; other site 191026014116 ATP binding site [chemical binding]; other site 191026014117 Walker B motif; other site 191026014118 arginine finger; other site 191026014119 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 191026014120 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 191026014121 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 191026014122 active site 191026014123 phosphorylation site [posttranslational modification] 191026014124 intermolecular recognition site; other site 191026014125 dimerization interface [polypeptide binding]; other site 191026014126 Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437 191026014127 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 191026014128 Zn2+ binding site [ion binding]; other site 191026014129 Mg2+ binding site [ion binding]; other site 191026014130 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 191026014131 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 191026014132 dimerization interface [polypeptide binding]; other site 191026014133 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 191026014134 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 191026014135 putative active site [active] 191026014136 heme pocket [chemical binding]; other site 191026014137 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 191026014138 dimer interface [polypeptide binding]; other site 191026014139 phosphorylation site [posttranslational modification] 191026014140 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 191026014141 ATP binding site [chemical binding]; other site 191026014142 Mg2+ binding site [ion binding]; other site 191026014143 G-X-G motif; other site 191026014144 Domain of unknown function (DUF4390); Region: DUF4390; pfam14334 191026014145 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 191026014146 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 191026014147 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 191026014148 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 191026014149 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cl02931 191026014150 Bacterial protein of unknown function (DUF883); Region: DUF883; cl01888 191026014151 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 191026014152 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 191026014153 putative active site [active] 191026014154 heme pocket [chemical binding]; other site 191026014155 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 191026014156 dimer interface [polypeptide binding]; other site 191026014157 phosphorylation site [posttranslational modification] 191026014158 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 191026014159 ATP binding site [chemical binding]; other site 191026014160 Mg2+ binding site [ion binding]; other site 191026014161 G-X-G motif; other site 191026014162 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 191026014163 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 191026014164 active site 191026014165 phosphorylation site [posttranslational modification] 191026014166 intermolecular recognition site; other site 191026014167 dimerization interface [polypeptide binding]; other site 191026014168 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 191026014169 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 191026014170 TPP-binding site [chemical binding]; other site 191026014171 dimer interface [polypeptide binding]; other site 191026014172 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 191026014173 PYR/PP interface [polypeptide binding]; other site 191026014174 dimer interface [polypeptide binding]; other site 191026014175 TPP binding site [chemical binding]; other site 191026014176 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 191026014177 Ribose/Galactose Isomerase; Region: LacAB_rpiB; pfam02502 191026014178 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 191026014179 binding surface 191026014180 Tetratricopeptide repeat; Region: TPR_16; pfam13432 191026014181 TPR motif; other site 191026014182 TPR repeat; Region: TPR_11; pfam13414 191026014183 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 191026014184 binding surface 191026014185 TPR motif; other site 191026014186 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 191026014187 binding surface 191026014188 TPR motif; other site 191026014189 TPR repeat; Region: TPR_11; pfam13414 191026014190 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 191026014191 binding surface 191026014192 TPR motif; other site 191026014193 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 191026014194 Zn2+ binding site [ion binding]; other site 191026014195 Mg2+ binding site [ion binding]; other site 191026014196 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 191026014197 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 191026014198 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 191026014199 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 191026014200 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 191026014201 DNA binding residues [nucleotide binding] 191026014202 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105 191026014203 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 191026014204 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 191026014205 substrate binding pocket [chemical binding]; other site 191026014206 dimer interface [polypeptide binding]; other site 191026014207 inhibitor binding site; inhibition site 191026014208 B12 binding domain of corrinoid proteins. A family of small methanogenic corrinoid proteins that bind methyl-Co(III) 5-hydroxybenzimidazolylcobamide as a cofactor. They play a role on the methanogenesis from trimethylamine, dimethylamine or...; Region: corrinoid_protein_B12-BD; cd02070 191026014209 methyltransferase cognate corrinoid proteins, Methanosarcina family; Region: pyl_corrinoid; TIGR02370 191026014210 B12 binding site [chemical binding]; other site 191026014211 cobalt ligand [ion binding]; other site 191026014212 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 191026014213 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 191026014214 catalytic residues [active] 191026014215 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 191026014216 Coenzyme A binding pocket [chemical binding]; other site 191026014217 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 191026014218 active site 191026014219 zinc-ribbon domain; Region: zinc_ribbon_5; pfam13719 191026014220 Protein of unknown function (DUF3426); Region: DUF3426; pfam11906 191026014221 DNA repair protein RadA; Provisional; Region: PRK11823 191026014222 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 191026014223 Walker A motif; other site 191026014224 ATP binding site [chemical binding]; other site 191026014225 Walker B motif; other site 191026014226 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 191026014227 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 191026014228 active site 191026014229 UDP-N-acetylglucosamine 2-epimerase; Region: Epimerase_2; pfam02350 191026014230 homodimer interface [polypeptide binding]; other site 191026014231 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 191026014232 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 191026014233 dimer interface [polypeptide binding]; other site 191026014234 active site 191026014235 CoA binding pocket [chemical binding]; other site 191026014236 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 191026014237 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 191026014238 glycosyltransferase, TIGR04182 family; Region: glyco_TIGR04182 191026014239 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 191026014240 Ligand binding site; other site 191026014241 Putative Catalytic site; other site 191026014242 DXD motif; other site 191026014243 Predicted membrane protein [Function unknown]; Region: COG2246 191026014244 GtrA-like protein; Region: GtrA; pfam04138 191026014245 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 191026014246 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 191026014247 putative active site [active] 191026014248 CAAX protease self-immunity; Region: Abi; pfam02517 191026014249 type II secretion system protein D; Region: type_II_gspD; TIGR02517 191026014250 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 191026014251 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 191026014252 Type II/IV secretion system protein; Region: T2SE; pfam00437 191026014253 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 191026014254 Walker A motif; other site 191026014255 ATP binding site [chemical binding]; other site 191026014256 Walker B motif; other site 191026014257 Uncharacterized membrane protein, required for N-linked glycosylation [General function prediction only]; Region: COG1287 191026014258 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 191026014259 DNA-binding interface [nucleotide binding]; DNA binding site 191026014260 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 191026014261 Integrase core domain; Region: rve; pfam00665 191026014262 Integrase core domain; Region: rve_3; pfam13683 191026014263 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 191026014264 active site 191026014265 catalytic site [active] 191026014266 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 191026014267 short chain dehydrogenase; Provisional; Region: PRK12937 191026014268 NAD(P) binding site [chemical binding]; other site 191026014269 active site 191026014270 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 191026014271 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 191026014272 NAD(P) binding site [chemical binding]; other site 191026014273 active site 191026014274 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 191026014275 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 191026014276 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 191026014277 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 191026014278 WcxM-like, Left-handed parallel beta-Helix (LbH) N-terminal domain: This group is composed of Xanthomonas campestris WcxM and proteins with similarity to the WcxM N-terminal domain. WcxM is thought to be bifunctional, catalyzing both the isomerization...; Region: LbH_WxcM_N_like; cd03358 191026014279 putative trimer interface [polypeptide binding]; other site 191026014280 putative active site [active] 191026014281 putative substrate binding site [chemical binding]; other site 191026014282 putative CoA binding site [chemical binding]; other site 191026014283 Methyltransferase domain; Region: Methyltransf_23; pfam13489 191026014284 Methyltransferase domain; Region: Methyltransf_11; pfam08241 191026014285 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 191026014286 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 191026014287 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Region: lipid_A_lpxD; TIGR01853 191026014288 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 191026014289 putative trimer interface [polypeptide binding]; other site 191026014290 putative CoA binding site [chemical binding]; other site 191026014291 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 191026014292 Predicted enzyme involved in methoxymalonyl-ACP biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FkbH; COG3882 191026014293 Acid Phosphatase; Region: Acid_PPase; cl17256 191026014294 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 191026014295 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 191026014296 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 191026014297 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 191026014298 trimer interface [polypeptide binding]; other site 191026014299 active site 191026014300 substrate binding site [chemical binding]; other site 191026014301 CoA binding site [chemical binding]; other site 191026014302 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 191026014303 extended (e) SDRs; Region: SDR_e; cd08946 191026014304 NAD(P) binding site [chemical binding]; other site 191026014305 substrate binding site [chemical binding]; other site 191026014306 active site 191026014307 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 191026014308 catalytic triad [active] 191026014309 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 191026014310 active site 191026014311 oxyanion hole [active] 191026014312 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 191026014313 Methyltransferase domain; Region: Methyltransf_31; pfam13847 191026014314 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 191026014315 S-adenosylmethionine binding site [chemical binding]; other site 191026014316 Aminoglycoside 3-N-acetyltransferase; Region: Antibiotic_NAT; cl01051 191026014317 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 191026014318 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 191026014319 acyl-activating enzyme (AAE) consensus motif; other site 191026014320 AMP binding site [chemical binding]; other site 191026014321 active site 191026014322 CoA binding site [chemical binding]; other site 191026014323 hypothetical protein; Validated; Region: PRK06201 191026014324 Demethylmenaquinone methyltransferase [Coenzyme metabolism]; Region: MenG; COG0684 191026014325 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 191026014326 4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase,; Validated; Region: PRK08195 191026014327 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974 191026014328 active site 191026014329 catalytic residues [active] 191026014330 metal binding site [ion binding]; metal-binding site 191026014331 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 191026014332 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 191026014333 pyridoxal 5'-phosphate binding site [chemical binding]; other site 191026014334 homodimer interface [polypeptide binding]; other site 191026014335 catalytic residue [active] 191026014336 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 191026014337 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 191026014338 NodB motif; other site 191026014339 active site 191026014340 metal binding site [ion binding]; metal-binding site 191026014341 Capsule polysaccharide export protein [Cell envelope biogenesis, outer membrane]; Region: KpsS; COG3562 191026014342 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain associated with the NTP (Nucleotidyl transferase) domain downstream. CBS is a small domain originally identified in cystathionine beta-synthase and subsequently...; Region: CBS_pair_NTP_transferase_assoc; cd04607 191026014343 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 191026014344 NTP_trnasferase_like_2 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_2; cd06426 191026014345 Substrate binding site; other site 191026014346 metal-binding site 191026014347 N-acetylneuraminate synthase; Region: NeuB_NnaB; TIGR03569 191026014348 NeuB family; Region: NeuB; pfam03102 191026014349 C-terminal SAF domain of sialic acid synthetase; Region: SAF_NeuB_like; cd11615 191026014350 NeuB binding interface [polypeptide binding]; other site 191026014351 putative substrate binding site [chemical binding]; other site 191026014352 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 191026014353 active site 191026014354 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 191026014355 Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360 191026014356 sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570 191026014357 putative trimer interface [polypeptide binding]; other site 191026014358 putative CoA binding site [chemical binding]; other site 191026014359 CMP-NeuAc_Synthase activates N-acetylneuraminic acid by adding CMP moiety; Region: CMP-NeuAc_Synthase; cd02513 191026014360 ligand binding site; other site 191026014361 tetramer interface; other site 191026014362 aminotransferase, LLPSF_NHT_00031 family; Region: NHT_00031; TIGR04181 191026014363 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 191026014364 inhibitor-cofactor binding pocket; inhibition site 191026014365 pyridoxal 5'-phosphate binding site [chemical binding]; other site 191026014366 catalytic residue [active] 191026014367 Arna decarboxylase_like, extended (e) SDRs; Region: Arna_like_SDR_e; cd05257 191026014368 NAD dependent epimerase/dehydratase, LLPSF_EDH_00030 family; Region: EDH_00030; TIGR04180 191026014369 NAD binding site [chemical binding]; other site 191026014370 substrate binding site [chemical binding]; other site 191026014371 active site 191026014372 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 191026014373 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 191026014374 putative trimer interface [polypeptide binding]; other site 191026014375 putative CoA binding site [chemical binding]; other site 191026014376 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 191026014377 FeS/SAM binding site; other site 191026014378 Radical SAM superfamily; Region: Radical_SAM; pfam04055 191026014379 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 191026014380 trimer interface [polypeptide binding]; other site 191026014381 active site 191026014382 UDP-GlcNAc binding site [chemical binding]; other site 191026014383 lipid binding site [chemical binding]; lipid-binding site 191026014384 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 191026014385 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 191026014386 acyl-activating enzyme (AAE) consensus motif; other site 191026014387 active site 191026014388 AMP binding site [chemical binding]; other site 191026014389 CoA binding site [chemical binding]; other site 191026014390 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 191026014391 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 191026014392 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 191026014393 Walker A/P-loop; other site 191026014394 ATP binding site [chemical binding]; other site 191026014395 Q-loop/lid; other site 191026014396 ABC transporter signature motif; other site 191026014397 Walker B; other site 191026014398 D-loop; other site 191026014399 H-loop/switch region; other site 191026014400 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 191026014401 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 191026014402 NAD(P) binding site [chemical binding]; other site 191026014403 active site 191026014404 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 191026014405 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 191026014406 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 191026014407 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 191026014408 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 191026014409 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 191026014410 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 191026014411 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 191026014412 putative trimer interface [polypeptide binding]; other site 191026014413 WcxM-like, Left-handed parallel beta-Helix (LbH) N-terminal domain: This group is composed of Xanthomonas campestris WcxM and proteins with similarity to the WcxM N-terminal domain. WcxM is thought to be bifunctional, catalyzing both the isomerization...; Region: LbH_WxcM_N_like; cd03358 191026014414 putative CoA binding site [chemical binding]; other site 191026014415 putative trimer interface [polypeptide binding]; other site 191026014416 putative active site [active] 191026014417 putative substrate binding site [chemical binding]; other site 191026014418 putative CoA binding site [chemical binding]; other site 191026014419 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 191026014420 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 191026014421 inhibitor-cofactor binding pocket; inhibition site 191026014422 pyridoxal 5'-phosphate binding site [chemical binding]; other site 191026014423 catalytic residue [active] 191026014424 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 191026014425 dimerization interface [polypeptide binding]; other site 191026014426 putative DNA binding site [nucleotide binding]; other site 191026014427 putative Zn2+ binding site [ion binding]; other site 191026014428 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 191026014429 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 191026014430 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 191026014431 NAD(P) binding site [chemical binding]; other site 191026014432 homodimer interface [polypeptide binding]; other site 191026014433 substrate binding site [chemical binding]; other site 191026014434 active site 191026014435 aminotransferase, LLPSF_NHT_00031 family; Region: NHT_00031; TIGR04181 191026014436 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 191026014437 inhibitor-cofactor binding pocket; inhibition site 191026014438 pyridoxal 5'-phosphate binding site [chemical binding]; other site 191026014439 catalytic residue [active] 191026014440 Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360 191026014441 sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570 191026014442 putative trimer interface [polypeptide binding]; other site 191026014443 putative CoA binding site [chemical binding]; other site 191026014444 Bacterial sugar transferase; Region: Bac_transf; pfam02397 191026014445 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 191026014446 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 191026014447 putative ADP-binding pocket [chemical binding]; other site 191026014448 exosortase A system-associated amidotransferase 1; Region: eps_aminotran_1; TIGR03108 191026014449 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 191026014450 active site 191026014451 dimer interface [polypeptide binding]; other site 191026014452 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 191026014453 Ligand Binding Site [chemical binding]; other site 191026014454 Molecular Tunnel; other site 191026014455 D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892 191026014456 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 191026014457 putative active site [active] 191026014458 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 191026014459 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 191026014460 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 191026014461 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 191026014462 putative type II secretion protein GspC; Provisional; Region: PRK09681 191026014463 Type IV pilus biogenesis; Region: Pilus_PilP; pfam11356 191026014464 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 191026014465 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 191026014466 Response regulator receiver domain; Region: Response_reg; pfam00072 191026014467 active site 191026014468 phosphorylation site [posttranslational modification] 191026014469 intermolecular recognition site; other site 191026014470 dimerization interface [polypeptide binding]; other site 191026014471 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 191026014472 ATP binding site [chemical binding]; other site 191026014473 Mg2+ binding site [ion binding]; other site 191026014474 G-X-G motif; other site 191026014475 FOG: WD40 repeat [General function prediction only]; Region: COG2319 191026014476 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 191026014477 structural tetrad; other site 191026014478 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 191026014479 type II secretion system protein G; Region: typeII_sec_gspG; TIGR01710 191026014480 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 191026014481 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 191026014482 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 191026014483 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830 191026014484 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830 191026014485 Type II secretion system (T2SS), protein K; Region: T2SK; pfam03934 191026014486 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 191026014487 S-adenosylmethionine binding site [chemical binding]; other site 191026014488 Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069 191026014489 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 191026014490 phosphate binding site [ion binding]; other site 191026014491 Soluble P-type ATPase [General function prediction only]; Region: COG4087 191026014492 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 191026014493 AMIN domain; Region: AMIN; pfam11741 191026014494 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 191026014495 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 191026014496 active site 191026014497 metal binding site [ion binding]; metal-binding site 191026014498 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 191026014499 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 191026014500 putative active site [active] 191026014501 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 191026014502 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 191026014503 Substrate binding site; other site 191026014504 Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050 191026014505 Archaeal ATPase; Region: Arch_ATPase; pfam01637 191026014506 Curli production assembly/transport component CsgG; Region: CsgG; cl17434 191026014507 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 191026014508 binding surface 191026014509 TPR motif; other site 191026014510 Integrase core domain; Region: rve; pfam00665 191026014511 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK08270 191026014512 ATP cone domain; Region: ATP-cone; pfam03477 191026014513 Class III ribonucleotide reductase; Region: RNR_III; cd01675 191026014514 effector binding site; other site 191026014515 active site 191026014516 Zn binding site [ion binding]; other site 191026014517 glycine loop; other site 191026014518 Cache domain; Region: Cache_1; pfam02743 191026014519 HAMP domain; Region: HAMP; pfam00672 191026014520 PAS fold; Region: PAS_4; pfam08448 191026014521 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 191026014522 putative active site [active] 191026014523 heme pocket [chemical binding]; other site 191026014524 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 191026014525 dimer interface [polypeptide binding]; other site 191026014526 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 191026014527 putative CheW interface [polypeptide binding]; other site 191026014528 Cache domain; Region: Cache_1; pfam02743 191026014529 HAMP domain; Region: HAMP; pfam00672 191026014530 PAS fold; Region: PAS_4; pfam08448 191026014531 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 191026014532 dimer interface [polypeptide binding]; other site 191026014533 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 191026014534 putative CheW interface [polypeptide binding]; other site 191026014535 sodium/proton antiporter; Reviewed; Region: nhaB; PRK09547 191026014536 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 191026014537 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 191026014538 putative trimer interface [polypeptide binding]; other site 191026014539 putative CoA binding site [chemical binding]; other site 191026014540 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 191026014541 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 191026014542 transmembrane helices; other site 191026014543 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 191026014544 Response regulator receiver domain; Region: Response_reg; pfam00072 191026014545 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 191026014546 active site 191026014547 phosphorylation site [posttranslational modification] 191026014548 intermolecular recognition site; other site 191026014549 dimerization interface [polypeptide binding]; other site 191026014550 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 191026014551 PAS domain; Region: PAS_9; pfam13426 191026014552 putative active site [active] 191026014553 heme pocket [chemical binding]; other site 191026014554 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 191026014555 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 191026014556 Walker A motif; other site 191026014557 ATP binding site [chemical binding]; other site 191026014558 Walker B motif; other site 191026014559 arginine finger; other site 191026014560 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 191026014561 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 191026014562 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 191026014563 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 191026014564 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 191026014565 active site 191026014566 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 191026014567 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 191026014568 L-threonine-O-3-phosphate decarboxylase; Region: L_thr_O3P_dcar; TIGR01140 191026014569 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 191026014570 pyridoxal 5'-phosphate binding site [chemical binding]; other site 191026014571 homodimer interface [polypeptide binding]; other site 191026014572 catalytic residue [active] 191026014573 cobyric acid synthase; Provisional; Region: PRK00784 191026014574 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 191026014575 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 191026014576 catalytic triad [active] 191026014577 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 191026014578 TPR motif; other site 191026014579 Tetratricopeptide repeat; Region: TPR_12; pfam13424 191026014580 binding surface 191026014581 Tetratricopeptide repeat; Region: TPR_12; pfam13424 191026014582 GAF domain; Region: GAF_3; pfam13492 191026014583 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 191026014584 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 191026014585 metal binding site [ion binding]; metal-binding site 191026014586 active site 191026014587 I-site; other site 191026014588 Response regulator receiver domain; Region: Response_reg; pfam00072 191026014589 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 191026014590 active site 191026014591 phosphorylation site [posttranslational modification] 191026014592 intermolecular recognition site; other site 191026014593 dimerization interface [polypeptide binding]; other site 191026014594 ROS/MUCR transcriptional regulator protein; Region: ROS_MUCR; pfam05443 191026014595 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 191026014596 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 191026014597 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 191026014598 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 191026014599 putative metal binding site; other site 191026014600 WxcM-like, C-terminal; Region: FdtA; pfam05523 191026014601 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 191026014602 DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041 191026014603 inhibitor-cofactor binding pocket; inhibition site 191026014604 pyridoxal 5'-phosphate binding site [chemical binding]; other site 191026014605 catalytic residue [active] 191026014606 putative oxidoreductase; Provisional; Region: PRK12831 191026014607 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 191026014608 Alanine dehydrogenase/PNT, C-terminal domain; Region: AlaDh_PNT_C; smart01002 191026014609 ferredoxin-NADP(+) reductase subunit alpha; Reviewed; Region: PRK06222 191026014610 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase-like proteins. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)...; Region: DHOD_e_trans_like1; cd06219 191026014611 FAD binding pocket [chemical binding]; other site 191026014612 FAD binding motif [chemical binding]; other site 191026014613 phosphate binding motif [ion binding]; other site 191026014614 beta-alpha-beta structure motif; other site 191026014615 NAD binding pocket [chemical binding]; other site 191026014616 Iron coordination center [ion binding]; other site 191026014617 GTP-binding protein LepA; Provisional; Region: PRK05433 191026014618 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 191026014619 G1 box; other site 191026014620 putative GEF interaction site [polypeptide binding]; other site 191026014621 GTP/Mg2+ binding site [chemical binding]; other site 191026014622 Switch I region; other site 191026014623 G2 box; other site 191026014624 G3 box; other site 191026014625 Switch II region; other site 191026014626 G4 box; other site 191026014627 G5 box; other site 191026014628 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 191026014629 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 191026014630 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 191026014631 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 191026014632 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 191026014633 Catalytic site [active] 191026014634 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 191026014635 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 191026014636 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 191026014637 Walker A motif; other site 191026014638 ATP binding site [chemical binding]; other site 191026014639 Walker B motif; other site 191026014640 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 191026014641 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 191026014642 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 191026014643 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 191026014644 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 191026014645 active site 191026014646 Protoporphyrinogen oxidase [Coenzyme metabolism]; Region: HemY; COG1232 191026014647 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 191026014648 PBP superfamily domain; Region: PBP_like_2; cl17296 191026014649 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 191026014650 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 191026014651 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 191026014652 dimer interface [polypeptide binding]; other site 191026014653 conserved gate region; other site 191026014654 putative PBP binding loops; other site 191026014655 ABC-ATPase subunit interface; other site 191026014656 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 191026014657 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 191026014658 dimer interface [polypeptide binding]; other site 191026014659 conserved gate region; other site 191026014660 putative PBP binding loops; other site 191026014661 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 191026014662 ABC-ATPase subunit interface; other site 191026014663 Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242 191026014664 rod shape-determining protein MreB; Provisional; Region: PRK13927 191026014665 MreB and similar proteins; Region: MreB_like; cd10225 191026014666 nucleotide binding site [chemical binding]; other site 191026014667 Mg binding site [ion binding]; other site 191026014668 putative protofilament interaction site [polypeptide binding]; other site 191026014669 RodZ interaction site [polypeptide binding]; other site 191026014670 rod shape-determining protein MreC; Provisional; Region: PRK13922 191026014671 rod shape-determining protein MreC; Region: MreC; pfam04085 191026014672 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 191026014673 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 191026014674 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 191026014675 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 191026014676 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 191026014677 F0F1 ATP synthase subunit B'; Validated; Region: PRK07353 191026014678 ATP synthase B/B' CF(0); Region: ATP-synt_B; pfam00430 191026014679 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 191026014680 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 191026014681 F0F1 ATP synthase subunit delta; Provisional; Region: PRK13429 191026014682 F0F1-type ATP synthase, delta subunit (mitochondrial oligomycin sensitivity protein) [Energy production and conversion]; Region: AtpH; cl17210 191026014683 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 191026014684 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 191026014685 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 191026014686 beta subunit interaction interface [polypeptide binding]; other site 191026014687 Walker A motif; other site 191026014688 ATP binding site [chemical binding]; other site 191026014689 Walker B motif; other site 191026014690 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 191026014691 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 191026014692 core domain interface [polypeptide binding]; other site 191026014693 delta subunit interface [polypeptide binding]; other site 191026014694 epsilon subunit interface [polypeptide binding]; other site 191026014695 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 191026014696 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 191026014697 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 191026014698 alpha subunit interaction interface [polypeptide binding]; other site 191026014699 Walker A motif; other site 191026014700 ATP binding site [chemical binding]; other site 191026014701 Walker B motif; other site 191026014702 inhibitor binding site; inhibition site 191026014703 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 191026014704 F0F1 ATP synthase subunit epsilon; Provisional; Region: atpC; PRK13446 191026014705 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 191026014706 gamma subunit interface [polypeptide binding]; other site 191026014707 epsilon subunit interface [polypeptide binding]; other site 191026014708 LBP interface [polypeptide binding]; other site 191026014709 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14356 191026014710 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 191026014711 Substrate binding site; other site 191026014712 Mg++ binding site; other site 191026014713 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 191026014714 active site 191026014715 substrate binding site [chemical binding]; other site 191026014716 CoA binding site [chemical binding]; other site 191026014717 Cell division protein ZapA; Region: ZapA; pfam05164 191026014718 phosphodiesterase; Provisional; Region: PRK12704 191026014719 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 191026014720 Zn2+ binding site [ion binding]; other site 191026014721 Mg2+ binding site [ion binding]; other site 191026014722 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 191026014723 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 191026014724 putative active site [active] 191026014725 metal binding site [ion binding]; metal-binding site 191026014726 homodimer binding site [polypeptide binding]; other site 191026014727 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 191026014728 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 191026014729 active site 191026014730 HIGH motif; other site 191026014731 dimer interface [polypeptide binding]; other site 191026014732 KMSKS motif; other site 191026014733 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 191026014734 RNA binding surface [nucleotide binding]; other site 191026014735 Protein of unknown function, DUF606; Region: DUF606; pfam04657 191026014736 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337 191026014737 UbiA prenyltransferase family; Region: UbiA; pfam01040 191026014738 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 191026014739 PAS domain; Region: PAS_9; pfam13426 191026014740 putative active site [active] 191026014741 heme pocket [chemical binding]; other site 191026014742 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 191026014743 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 191026014744 dimer interface [polypeptide binding]; other site 191026014745 putative CheW interface [polypeptide binding]; other site 191026014746 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 191026014747 Histone deacetylases and histone-like deacetylases, classII; Region: HDAC_classII; cd09992 191026014748 active site 191026014749 Zn binding site [ion binding]; other site 191026014750 Nitrous oxide-stimulated promoter; Region: YgbA_NO; cl08119 191026014751 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 191026014752 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 191026014753 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 191026014754 GAF domain; Region: GAF_3; pfam13492 191026014755 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 191026014756 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 191026014757 Walker A motif; other site 191026014758 ATP binding site [chemical binding]; other site 191026014759 Walker B motif; other site 191026014760 arginine finger; other site 191026014761 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 191026014762 Metal binding protein ZntC. These proteins are predicted to function as initial receptors in ABC transport of metal ions. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and ligand binding...; Region: ZntC; cd01018 191026014763 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 191026014764 putative metal binding residues [ion binding]; other site 191026014765 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 191026014766 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 191026014767 Nitrogen regulatory protein P-II; Region: P-II; smart00938 191026014768 UTP:GlnB (protein PII) uridylyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: GlnD; COG2844 191026014769 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 191026014770 metal binding triad; other site 191026014771 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 191026014772 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 191026014773 Zn2+ binding site [ion binding]; other site 191026014774 Mg2+ binding site [ion binding]; other site 191026014775 ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900 191026014776 ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD; Region: ACT_UUR-ACR-like; cd04873 191026014777 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 191026014778 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 191026014779 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 191026014780 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 191026014781 AIR carboxylase; Region: AIRC; pfam00731 191026014782 Response regulator receiver domain; Region: Response_reg; pfam00072 191026014783 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 191026014784 active site 191026014785 phosphorylation site [posttranslational modification] 191026014786 intermolecular recognition site; other site 191026014787 dimerization interface [polypeptide binding]; other site 191026014788 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086 191026014789 putative binding surface; other site 191026014790 active site 191026014791 heat shock protein 90; Provisional; Region: PRK05218 191026014792 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 191026014793 ATP binding site [chemical binding]; other site 191026014794 Mg2+ binding site [ion binding]; other site 191026014795 G-X-G motif; other site 191026014796 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 191026014797 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 191026014798 DNA binding residues [nucleotide binding] 191026014799 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 191026014800 nucleotide binding site [chemical binding]; other site 191026014801 Type III pantothenate kinase; Region: Pan_kinase; cl17198 191026014802 enolase; Provisional; Region: eno; PRK00077 191026014803 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 191026014804 dimer interface [polypeptide binding]; other site 191026014805 metal binding site [ion binding]; metal-binding site 191026014806 substrate binding pocket [chemical binding]; other site 191026014807 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14184 191026014808 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 191026014809 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 191026014810 homodimer interface [polypeptide binding]; other site 191026014811 NADP binding site [chemical binding]; other site 191026014812 substrate binding site [chemical binding]; other site 191026014813 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 191026014814 Zn2+ binding site [ion binding]; other site 191026014815 Mg2+ binding site [ion binding]; other site 191026014816 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 191026014817 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 191026014818 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 191026014819 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 191026014820 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086 191026014821 putative binding surface; other site 191026014822 active site 191026014823 Alpha-acetolactate decarboxylase; Region: AAL_decarboxy; pfam03306 191026014824 CheD chemotactic sensory transduction; Region: CheD; cl00810 191026014825 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 191026014826 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 191026014827 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 191026014828 anti sigma factor interaction site; other site 191026014829 regulatory phosphorylation site [posttranslational modification]; other site 191026014830 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 191026014831 putative substrate translocation pore; other site 191026014832 Protein of unknown function DUF45; Region: DUF45; pfam01863 191026014833 aspartate aminotransferase; Provisional; Region: PRK06836 191026014834 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 191026014835 pyridoxal 5'-phosphate binding site [chemical binding]; other site 191026014836 homodimer interface [polypeptide binding]; other site 191026014837 catalytic residue [active] 191026014838 helicase 45; Provisional; Region: PTZ00424 191026014839 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 191026014840 ATP binding site [chemical binding]; other site 191026014841 Mg++ binding site [ion binding]; other site 191026014842 motif III; other site 191026014843 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 191026014844 nucleotide binding region [chemical binding]; other site 191026014845 ATP-binding site [chemical binding]; other site 191026014846 Methylamine utilisation protein MauE; Region: MauE; pfam07291 191026014847 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 191026014848 active site residue [active] 191026014849 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 191026014850 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 191026014851 dimerization interface [polypeptide binding]; other site 191026014852 PAS domain; Region: PAS; smart00091 191026014853 PAS fold; Region: PAS_4; pfam08448 191026014854 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 191026014855 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 191026014856 dimer interface [polypeptide binding]; other site 191026014857 putative CheW interface [polypeptide binding]; other site 191026014858 glycyl-radical enzyme activating protein family; Region: PFLE_PFLC; TIGR02494 191026014859 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 191026014860 glycyl radical enzyme, PFL2/glycerol dehydratase family; Region: PFL2-3; TIGR01774 191026014861 Pyruvate formate lyase 2 and related enzymes; Region: PFL2_DhaB_BssA; cd01677 191026014862 dimer interface [polypeptide binding]; other site 191026014863 active site 191026014864 glycine loop; other site 191026014865 Domain of unknown function (DUF336); Region: DUF336; pfam03928 191026014866 Sensory domain found in PocR; Region: PocR; pfam10114 191026014867 Predicted sensor domain [Signal transduction mechanisms / Transcription]; Region: PocR; COG4936 191026014868 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 191026014869 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 191026014870 putative active site [active] 191026014871 heme pocket [chemical binding]; other site 191026014872 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 191026014873 dimer interface [polypeptide binding]; other site 191026014874 phosphorylation site [posttranslational modification] 191026014875 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 191026014876 ATP binding site [chemical binding]; other site 191026014877 Mg2+ binding site [ion binding]; other site 191026014878 G-X-G motif; other site 191026014879 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 191026014880 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 191026014881 active site 191026014882 phosphorylation site [posttranslational modification] 191026014883 intermolecular recognition site; other site 191026014884 dimerization interface [polypeptide binding]; other site 191026014885 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 191026014886 Walker A motif; other site 191026014887 ATP binding site [chemical binding]; other site 191026014888 Walker B motif; other site 191026014889 arginine finger; other site 191026014890 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 191026014891 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 191026014892 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 191026014893 active site 191026014894 dimer interface [polypeptide binding]; other site 191026014895 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 191026014896 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 191026014897 active site 191026014898 trimer interface [polypeptide binding]; other site 191026014899 allosteric site; other site 191026014900 active site lid [active] 191026014901 hexamer (dimer of trimers) interface [polypeptide binding]; other site 191026014902 PTS system N-acetyl glucosamine specific transporter subunits IIABC; Provisional; Region: PRK10255 191026014903 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 191026014904 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 191026014905 active site turn [active] 191026014906 phosphorylation site [posttranslational modification] 191026014907 PTS system glucose-specific transporter subunit; Provisional; Region: PRK09439 191026014908 HPr interaction site; other site 191026014909 glycerol kinase (GK) interaction site [polypeptide binding]; other site 191026014910 active site 191026014911 phosphorylation site [posttranslational modification] 191026014912 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 191026014913 dimerization domain swap beta strand [polypeptide binding]; other site 191026014914 regulatory protein interface [polypeptide binding]; other site 191026014915 active site 191026014916 regulatory phosphorylation site [posttranslational modification]; other site 191026014917 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 191026014918 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 191026014919 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 191026014920 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 191026014921 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 191026014922 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 191026014923 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 191026014924 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 191026014925 RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399 191026014926 Protein of unknown function (DUF1611); Region: DUF1611; pfam07755 191026014927 Predicted amino acid racemase [Amino acid transport and metabolism]; Region: COG3457 191026014928 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase-like 1; Region: PLPDE_III_AR_like_1; cd06815 191026014929 active site 191026014930 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 191026014931 dimer interface [polypeptide binding]; other site 191026014932 substrate binding site [chemical binding]; other site 191026014933 catalytic residue [active] 191026014934 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 191026014935 active site 191026014936 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 191026014937 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 191026014938 Sulfate transporter family; Region: Sulfate_transp; pfam00916 191026014939 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 191026014940 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 191026014941 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 191026014942 substrate binding pocket [chemical binding]; other site 191026014943 membrane-bound complex binding site; other site 191026014944 hinge residues; other site 191026014945 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 191026014946 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 191026014947 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 191026014948 active site 191026014949 AMP binding site [chemical binding]; other site 191026014950 acyl-activating enzyme (AAE) consensus motif; other site 191026014951 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 191026014952 CoA binding site [chemical binding]; other site 191026014953 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 191026014954 active site 191026014955 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 191026014956 3-oxoacyl-acyl carrier protein synthase; Provisional; Region: PTZ00050 191026014957 dimer interface [polypeptide binding]; other site 191026014958 active site 191026014959 Phosphopantetheine attachment site; Region: PP-binding; cl09936 191026014960 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 191026014961 putative acyl-acceptor binding pocket; other site 191026014962 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 191026014963 Ligand binding site; other site 191026014964 Putative Catalytic site; other site 191026014965 DXD motif; other site 191026014966 Uncharacterized protein conserved in bacteria (DUF2062); Region: DUF2062; pfam09835 191026014967 lipid biosynthesis B12-binding/radical SAM protein; Region: rSAM_ladder_B12; TIGR04072 191026014968 Fe-S oxidoreductase [Energy production and conversion]; Region: COG1032 191026014969 B12 binding site [chemical binding]; other site 191026014970 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377 191026014971 FeS/SAM binding site; other site 191026014972 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 191026014973 active site 191026014974 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 191026014975 active site 2 [active] 191026014976 active site 1 [active] 191026014977 Predicted exporter [General function prediction only]; Region: COG4258 191026014978 Sterol-sensing domain of SREBP cleavage-activation; Region: Sterol-sensing; pfam12349 191026014979 lipoprotein chaperone; Reviewed; Region: lolA; PRK00031 191026014980 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl17548 191026014981 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 191026014982 active site 2 [active] 191026014983 active site 1 [active] 191026014984 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 191026014985 putative heme d1 biosynthesis radical SAM protein NirJ2; Region: rSAM_NirJ2; TIGR04055 191026014986 FeS/SAM binding site; other site 191026014987 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 191026014988 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 191026014989 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 191026014990 putative acyl-acceptor binding pocket; other site 191026014991 Phosphopantetheine attachment site; Region: PP-binding; cl09936 191026014992 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK09116 191026014993 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 191026014994 dimer interface [polypeptide binding]; other site 191026014995 active site 191026014996 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 191026014997 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 191026014998 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 191026014999 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 191026015000 dimer interface [polypeptide binding]; other site 191026015001 active site 191026015002 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 191026015003 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 191026015004 NAD(P) binding site [chemical binding]; other site 191026015005 homotetramer interface [polypeptide binding]; other site 191026015006 homodimer interface [polypeptide binding]; other site 191026015007 active site 191026015008 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 191026015009 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 191026015010 PAS fold; Region: PAS_3; pfam08447 191026015011 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 191026015012 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 191026015013 metal binding site [ion binding]; metal-binding site 191026015014 active site 191026015015 I-site; other site 191026015016 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 191026015017 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 191026015018 putative active site [active] 191026015019 heme pocket [chemical binding]; other site 191026015020 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 191026015021 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 191026015022 putative active site [active] 191026015023 heme pocket [chemical binding]; other site 191026015024 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 191026015025 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 191026015026 putative active site [active] 191026015027 heme pocket [chemical binding]; other site 191026015028 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 191026015029 putative active site [active] 191026015030 heme pocket [chemical binding]; other site 191026015031 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 191026015032 dimer interface [polypeptide binding]; other site 191026015033 phosphorylation site [posttranslational modification] 191026015034 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 191026015035 ATP binding site [chemical binding]; other site 191026015036 Mg2+ binding site [ion binding]; other site 191026015037 G-X-G motif; other site 191026015038 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 191026015039 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 191026015040 active site 191026015041 phosphorylation site [posttranslational modification] 191026015042 intermolecular recognition site; other site 191026015043 dimerization interface [polypeptide binding]; other site 191026015044 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 191026015045 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 191026015046 HlyD family secretion protein; Region: HlyD_3; pfam13437 191026015047 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 191026015048 Suppressor of fused protein (SUFU); Region: SUFU; pfam05076 191026015049 Protein export membrane protein; Region: SecD_SecF; cl14618 191026015050 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 191026015051 NeuB family; Region: NeuB; pfam03102 191026015052 N-terminal domain of RfaE; Region: RfaE_N; cd02172 191026015053 putative active site [active] 191026015054 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 191026015055 (T/H)XGH motif; other site 191026015056 RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172 191026015057 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 191026015058 putative ribose interaction site [chemical binding]; other site 191026015059 putative ADP binding site [chemical binding]; other site 191026015060 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 191026015061 active site 191026015062 dimer interface [polypeptide binding]; other site 191026015063 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 191026015064 Radical SAM superfamily; Region: Radical_SAM; pfam04055 191026015065 FeS/SAM binding site; other site 191026015066 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 191026015067 Phosphotransferase enzyme family; Region: APH; pfam01636 191026015068 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 191026015069 active site 191026015070 ATP binding site [chemical binding]; other site 191026015071 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 191026015072 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 191026015073 TPP-binding site [chemical binding]; other site 191026015074 dimer interface [polypeptide binding]; other site 191026015075 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 191026015076 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 191026015077 PYR/PP interface [polypeptide binding]; other site 191026015078 dimer interface [polypeptide binding]; other site 191026015079 TPP binding site [chemical binding]; other site 191026015080 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 191026015081 Methyltransferase domain; Region: Methyltransf_31; pfam13847 191026015082 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 191026015083 S-adenosylmethionine binding site [chemical binding]; other site 191026015084 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535 191026015085 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 191026015086 FeS/SAM binding site; other site 191026015087 CMP-NeuAc_Synthase activates N-acetylneuraminic acid by adding CMP moiety; Region: CMP-NeuAc_Synthase; cd02513 191026015088 ligand binding site; other site 191026015089 tetramer interface; other site 191026015090 N-acetylneuraminate synthase; Region: NeuB_NnaB; TIGR03569 191026015091 NeuB family; Region: NeuB; pfam03102 191026015092 C-terminal SAF domain of sialic acid synthetase; Region: SAF_NeuB_like; cd11615 191026015093 NeuB binding interface [polypeptide binding]; other site 191026015094 putative substrate binding site [chemical binding]; other site 191026015095 UDP-N-acetyl-D-glucosamine 2-epimerase, UDP-hydrolysing; Region: NeuC_NnaA; TIGR03568 191026015096 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 191026015097 active site 191026015098 homodimer interface [polypeptide binding]; other site 191026015099 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 191026015100 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 191026015101 active site 191026015102 metal binding site [ion binding]; metal-binding site 191026015103 LuxQ, periplasmic; Region: LuxQ-periplasm; pfam09308 191026015104 HAMP domain; Region: HAMP; pfam00672 191026015105 PAS domain S-box; Region: sensory_box; TIGR00229 191026015106 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 191026015107 putative active site [active] 191026015108 heme pocket [chemical binding]; other site 191026015109 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 191026015110 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 191026015111 putative active site [active] 191026015112 heme pocket [chemical binding]; other site 191026015113 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 191026015114 dimer interface [polypeptide binding]; other site 191026015115 phosphorylation site [posttranslational modification] 191026015116 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 191026015117 ATP binding site [chemical binding]; other site 191026015118 Mg2+ binding site [ion binding]; other site 191026015119 G-X-G motif; other site 191026015120 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 191026015121 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 191026015122 Uncharacterized member of the PurR regulon [General function prediction only]; Region: yhhQ; COG1738 191026015123 7-cyano-7-deazaguanine reductase; Provisional; Region: PRK13258 191026015124 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 191026015125 dimerization interface [polypeptide binding]; other site 191026015126 putative DNA binding site [nucleotide binding]; other site 191026015127 putative Zn2+ binding site [ion binding]; other site 191026015128 Predicted permeases [General function prediction only]; Region: COG0701 191026015129 DGC domain; Region: DGC; pfam08859 191026015130 Response regulator receiver domain; Region: Response_reg; pfam00072 191026015131 Response regulator receiver domain; Region: Response_reg; pfam00072 191026015132 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 191026015133 active site 191026015134 phosphorylation site [posttranslational modification] 191026015135 intermolecular recognition site; other site 191026015136 dimerization interface [polypeptide binding]; other site 191026015137 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 191026015138 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 191026015139 metal binding site [ion binding]; metal-binding site 191026015140 active site 191026015141 I-site; other site 191026015142 Late competence development protein ComFB; Region: ComFB; pfam10719 191026015143 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 191026015144 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 191026015145 HlyD family secretion protein; Region: HlyD_3; pfam13437 191026015146 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 191026015147 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 191026015148 PAS domain; Region: PAS_9; pfam13426 191026015149 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 191026015150 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 191026015151 ATP binding site [chemical binding]; other site 191026015152 Mg2+ binding site [ion binding]; other site 191026015153 G-X-G motif; other site 191026015154 META domain; Region: META; pfam03724 191026015155 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 191026015156 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 191026015157 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 191026015158 Domain of unknown function (DUF3391); Region: DUF3391; pfam11871 191026015159 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 191026015160 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 191026015161 Zn2+ binding site [ion binding]; other site 191026015162 Mg2+ binding site [ion binding]; other site 191026015163 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319 191026015164 active site 191026015165 4Fe-4S binding domain; Region: Fer4; pfam00037 191026015166 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 191026015167 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 191026015168 phosphate binding site [ion binding]; other site 191026015169 GXGXG domain. This domain of unknown function is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS), in subunit C of tungsten formylmethanofuran dehydrogenase (FwdC) and in subunit C of molybdenum formylmethanofuran...; Region: GXGXG; cl00239 191026015170 domain_subunit interface; other site 191026015171 putative glutamate synthase (NADPH) small subunit; Provisional; Region: PRK12771 191026015172 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 191026015173 4Fe-4S binding domain; Region: Fer4; pfam00037 191026015174 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 191026015175 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 191026015176 active site 191026015177 Bacterial OB fold (BOF) protein; Region: BOF; cl01196 191026015178 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 191026015179 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 191026015180 dimerization interface [polypeptide binding]; other site 191026015181 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 191026015182 dimer interface [polypeptide binding]; other site 191026015183 phosphorylation site [posttranslational modification] 191026015184 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 191026015185 ATP binding site [chemical binding]; other site 191026015186 Mg2+ binding site [ion binding]; other site 191026015187 G-X-G motif; other site 191026015188 Response regulator receiver domain; Region: Response_reg; pfam00072 191026015189 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 191026015190 active site 191026015191 phosphorylation site [posttranslational modification] 191026015192 intermolecular recognition site; other site 191026015193 dimerization interface [polypeptide binding]; other site 191026015194 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 191026015195 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 191026015196 ligand binding site [chemical binding]; other site 191026015197 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 191026015198 EamA-like transporter family; Region: EamA; pfam00892 191026015199 EamA-like transporter family; Region: EamA; pfam00892 191026015200 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 191026015201 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 191026015202 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 191026015203 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 191026015204 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 191026015205 DNA binding site [nucleotide binding] 191026015206 active site 191026015207 HDOD domain; Region: HDOD; pfam08668 191026015208 GAF domain; Region: GAF_3; pfam13492 191026015209 PAS domain; Region: PAS; smart00091 191026015210 PAS domain; Region: PAS_9; pfam13426 191026015211 putative active site [active] 191026015212 heme pocket [chemical binding]; other site 191026015213 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 191026015214 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 191026015215 dimer interface [polypeptide binding]; other site 191026015216 phosphorylation site [posttranslational modification] 191026015217 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 191026015218 ATP binding site [chemical binding]; other site 191026015219 Mg2+ binding site [ion binding]; other site 191026015220 G-X-G motif; other site 191026015221 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 191026015222 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 191026015223 PhnA protein; Region: PhnA; pfam03831 191026015224 DhnA-type fructose-1,6-bisphosphate aldolase and related enzymes [Carbohydrate transport and metabolism]; Region: FbaB; COG1830 191026015225 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 191026015226 putative active site; other site 191026015227 catalytic residue [active] 191026015228 tRNA and rRNA cytosine-C5-methylases [Translation, ribosomal structure and biogenesis]; Region: Sun; COG0144 191026015229 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 191026015230 S-adenosylmethionine binding site [chemical binding]; other site 191026015231 Family description; Region: VCBS; pfam13517 191026015232 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 191026015233 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 191026015234 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290 191026015235 DctM-like transporters; Region: DctM; pfam06808 191026015236 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 191026015237 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 191026015238 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 191026015239 RNA binding surface [nucleotide binding]; other site 191026015240 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 191026015241 active site 191026015242 Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I) [Energy production and conversion]; Region: NuoI; COG1143 191026015243 NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338 191026015244 Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261 191026015245 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl16917 191026015246 Ni,Fe-hydrogenase III small subunit [Energy production and conversion]; Region: COG3260 191026015247 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 191026015248 NADH dehydrogenase; Region: NADHdh; cl00469 191026015249 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12667 191026015250 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 191026015251 Orthopoxvirus protein of unknown function (DUF830); Region: DUF830; cl13998 191026015252 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 191026015253 NlpC/P60 family; Region: NLPC_P60; pfam00877 191026015254 putative regulatory protein, FmdB family; Region: CxxC_CxxC_SSSS; TIGR02605 191026015255 adenylosuccinate lyase; Provisional; Region: PRK07492 191026015256 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 191026015257 tetramer interface [polypeptide binding]; other site 191026015258 active site 191026015259 Adenylosuccinate lyase C-terminus; Region: ADSL_C; smart00998 191026015260 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 191026015261 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3034 191026015262 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 191026015263 active site 191026015264 Zn binding site [ion binding]; other site 191026015265 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 191026015266 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 191026015267 Metal-binding active site; metal-binding site 191026015268 DctM-like transporters; Region: DctM; pfam06808 191026015269 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274 191026015270 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290 191026015271 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 191026015272 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 191026015273 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 191026015274 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 191026015275 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 191026015276 Hydantoinase B/oxoprolinase; Region: Hydantoinase_B; pfam02538 191026015277 Branched-chain amino acid transport protein (AzlD); Region: AzlD; cl00735 191026015278 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 191026015279 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 191026015280 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 191026015281 DNA-binding site [nucleotide binding]; DNA binding site 191026015282 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 191026015283 pyridoxal 5'-phosphate binding site [chemical binding]; other site 191026015284 homodimer interface [polypeptide binding]; other site 191026015285 catalytic residue [active] 191026015286 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 191026015287 binding surface 191026015288 Tetratricopeptide repeat; Region: TPR_16; pfam13432 191026015289 TPR motif; other site 191026015290 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 191026015291 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 191026015292 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 191026015293 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 191026015294 RNA binding site [nucleotide binding]; other site 191026015295 Response regulator receiver domain; Region: Response_reg; pfam00072 191026015296 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 191026015297 active site 191026015298 phosphorylation site [posttranslational modification] 191026015299 intermolecular recognition site; other site 191026015300 dimerization interface [polypeptide binding]; other site 191026015301 3D domain; Region: 3D; cl01439 191026015302 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 191026015303 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 191026015304 Walker A/P-loop; other site 191026015305 ATP binding site [chemical binding]; other site 191026015306 Q-loop/lid; other site 191026015307 ABC transporter signature motif; other site 191026015308 Walker B; other site 191026015309 D-loop; other site 191026015310 H-loop/switch region; other site 191026015311 cobalt ABC transporter, permease protein CbiQ; Region: CbiQ_TIGR; TIGR02454 191026015312 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 191026015313 S-adenosylmethionine binding site [chemical binding]; other site 191026015314 Shikimate kinase; Region: SKI; pfam01202 191026015315 Amidinotransferase; Region: Amidinotransf; cl12043 191026015316 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 191026015317 Ligand binding site; other site 191026015318 DXD motif; other site 191026015319 Putative Catalytic site; other site 191026015320 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 191026015321 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 191026015322 Tetratricopeptide repeat; Region: TPR_16; pfam13432 191026015323 TPR motif; other site 191026015324 binding surface 191026015325 TPR repeat; Region: TPR_11; pfam13414 191026015326 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 191026015327 TPR repeat; Region: TPR_11; pfam13414 191026015328 binding surface 191026015329 TPR motif; other site 191026015330 Protein of unknown function (DUF401); Region: DUF401; cl00830 191026015331 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 191026015332 substrate binding site [chemical binding]; other site 191026015333 Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437 191026015334 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 191026015335 active site 191026015336 phosphorylation site [posttranslational modification] 191026015337 intermolecular recognition site; other site 191026015338 dimerization interface [polypeptide binding]; other site 191026015339 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 191026015340 Zn2+ binding site [ion binding]; other site 191026015341 Mg2+ binding site [ion binding]; other site 191026015342 4Fe-4S binding domain; Region: Fer4; pfam00037 191026015343 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 191026015344 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 191026015345 anti sigma factor interaction site; other site 191026015346 regulatory phosphorylation site [posttranslational modification]; other site 191026015347 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 191026015348 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 191026015349 multifunctional aminopeptidase A; Provisional; Region: PRK00913 191026015350 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 191026015351 interface (dimer of trimers) [polypeptide binding]; other site 191026015352 Substrate-binding/catalytic site; other site 191026015353 Zn-binding sites [ion binding]; other site 191026015354 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 191026015355 active site 191026015356 homotetramer interface [polypeptide binding]; other site 191026015357 homodimer interface [polypeptide binding]; other site 191026015358 PAS domain; Region: PAS_9; pfam13426 191026015359 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 191026015360 putative active site [active] 191026015361 heme pocket [chemical binding]; other site 191026015362 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 191026015363 PAS fold; Region: PAS_3; pfam08447 191026015364 putative active site [active] 191026015365 heme pocket [chemical binding]; other site 191026015366 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 191026015367 dimer interface [polypeptide binding]; other site 191026015368 phosphorylation site [posttranslational modification] 191026015369 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 191026015370 ATP binding site [chemical binding]; other site 191026015371 Mg2+ binding site [ion binding]; other site 191026015372 G-X-G motif; other site 191026015373 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 191026015374 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 191026015375 G1 box; other site 191026015376 putative GEF interaction site [polypeptide binding]; other site 191026015377 GTP/Mg2+ binding site [chemical binding]; other site 191026015378 Switch I region; other site 191026015379 G2 box; other site 191026015380 G3 box; other site 191026015381 Switch II region; other site 191026015382 G4 box; other site 191026015383 G5 box; other site 191026015384 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 191026015385 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 191026015386 FAD-dependent thymidylate synthase; Reviewed; Region: thyX; PRK00847 191026015387 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 191026015388 DnaA N-terminal domain; Region: DnaA_N; pfam11638 191026015389 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 191026015390 Walker A motif; other site 191026015391 ATP binding site [chemical binding]; other site 191026015392 Walker B motif; other site 191026015393 arginine finger; other site 191026015394 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 191026015395 DnaA box-binding interface [nucleotide binding]; other site 191026015396 DnaA N-terminal domain; Region: DnaA_N; pfam11638 191026015397 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 191026015398 PIN domain; Region: PIN_Smg5-Smg6-like; cd09880 191026015399 putative active site [active] 191026015400 PhoH-like protein; Region: PhoH; cl17668 191026015401 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 191026015402 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 191026015403 dimer interface [polypeptide binding]; other site 191026015404 putative functional site; other site 191026015405 putative MPT binding site; other site 191026015406 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 191026015407 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 191026015408 GTP binding site; other site 191026015409 Peptidase family C54; Region: Peptidase_C54; pfam03416 191026015410 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 191026015411 acetyl coenzyme A synthetase (ADP forming), alpha domain; Region: AcCoA-syn-alpha; TIGR02717 191026015412 CoA binding domain; Region: CoA_binding_2; pfam13380 191026015413 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 191026015414 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 191026015415 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 191026015416 BioD-like N-terminal domain of phosphotransacetylase [General function prediction only]; Region: Pta; COG0857 191026015417 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 191026015418 DRTGG domain; Region: DRTGG; pfam07085 191026015419 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 191026015420 Cysteine-rich domain; Region: CCG; pfam02754 191026015421 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168 191026015422 heme-binding residues [chemical binding]; other site 191026015423 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 191026015424 active site 191026015425 GTP-binding protein YchF; Reviewed; Region: PRK09601 191026015426 YchF GTPase; Region: YchF; cd01900 191026015427 G1 box; other site 191026015428 GTP/Mg2+ binding site [chemical binding]; other site 191026015429 Switch I region; other site 191026015430 G2 box; other site 191026015431 Switch II region; other site 191026015432 G3 box; other site 191026015433 G4 box; other site 191026015434 G5 box; other site 191026015435 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 191026015436 Domain of unknown function (DUF697); Region: DUF697; cl12064 191026015437 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 191026015438 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 191026015439 Phosphocholine cytidylyltransferases catalyze the synthesis of CDP-choline; Region: PC_cytidylyltransferase; cd02523 191026015440 active site 191026015441 metal-binding site 191026015442 CMP-NeuAc_Synthase activates N-acetylneuraminic acid by adding CMP moiety; Region: CMP-NeuAc_Synthase; cd02513 191026015443 ligand binding site; other site 191026015444 tetramer interface; other site 191026015445 Spore coat polysaccharide biosynthesis protein, predicted glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: spsG; COG3980 191026015446 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 191026015447 Methyltransferase domain; Region: Methyltransf_23; pfam13489 191026015448 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 191026015449 S-adenosylmethionine binding site [chemical binding]; other site 191026015450 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4627 191026015451 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 191026015452 Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465 191026015453 active site 191026015454 NAD binding site [chemical binding]; other site 191026015455 metal binding site [ion binding]; metal-binding site 191026015456 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 191026015457 PYR/PP interface [polypeptide binding]; other site 191026015458 dimer interface [polypeptide binding]; other site 191026015459 TPP binding site [chemical binding]; other site 191026015460 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 191026015461 TPP-binding site [chemical binding]; other site 191026015462 Sialic acid synthase [Cell envelope biogenesis, outer membrane]; Region: SpsE; COG2089 191026015463 NeuB family; Region: NeuB; pfam03102 191026015464 C-terminal SAF domain of sialic acid synthetase; Region: SAF_NeuB_like; cd11615 191026015465 putative substrate binding site [chemical binding]; other site 191026015466 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 191026015467 active site 191026015468 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 191026015469 S-adenosylmethionine binding site [chemical binding]; other site 191026015470 Predicted ATP-dependent carboligase related to biotin carboxylase [General function prediction only]; Region: COG2232 191026015471 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 191026015472 N-terminal catalytic domain of alpha-galactosidase; glycoside hydrolase family 57 (GH57); Region: GH57N_PfGalA_like; cd10794 191026015473 putative active site [active] 191026015474 catalytic site [active] 191026015475 UDP-N-acetylglucosamine 4,6-dehydratase; Region: PseB; TIGR03589 191026015476 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 191026015477 NAD(P) binding site [chemical binding]; other site 191026015478 homodimer interface [polypeptide binding]; other site 191026015479 substrate binding site [chemical binding]; other site 191026015480 active site 191026015481 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 191026015482 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 191026015483 inhibitor-cofactor binding pocket; inhibition site 191026015484 pyridoxal 5'-phosphate binding site [chemical binding]; other site 191026015485 catalytic residue [active] 191026015486 BNR repeat-like domain; Region: BNR_2; pfam13088 191026015487 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cl17698 191026015488 Asp-box motif; other site 191026015489 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 191026015490 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 191026015491 NAD(P) binding site [chemical binding]; other site 191026015492 active site 191026015493 HI0933-like protein; Region: HI0933_like; pfam03486 191026015494 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 191026015495 Response regulator receiver domain; Region: Response_reg; pfam00072 191026015496 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 191026015497 active site 191026015498 phosphorylation site [posttranslational modification] 191026015499 intermolecular recognition site; other site 191026015500 dimerization interface [polypeptide binding]; other site 191026015501 cytochrome-c3 hydrogenase subunit gamma; Provisional; Region: PRK08345 191026015502 Anaerobic sulfite reductase contains an FAD and NADPH binding module with structural similarity to ferredoxin reductase and sequence similarity to dihydroorotate dehydrogenases. Clostridium pasteurianum inducible dissimilatory type sulfite reductase is...; Region: sulfite_reductase_like; cd06221 191026015503 FAD binding pocket [chemical binding]; other site 191026015504 FAD binding motif [chemical binding]; other site 191026015505 phosphate binding motif [ion binding]; other site 191026015506 beta-alpha-beta structure motif; other site 191026015507 NAD binding pocket [chemical binding]; other site 191026015508 Iron coordination center [ion binding]; other site 191026015509 anaerobic sulfite reductase subunit A; Provisional; Region: PRK15055 191026015510 Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus; Region: FrhB_FdhB_C; pfam04432 191026015511 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 191026015512 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 191026015513 Methyl-viologen-reducing hydrogenase, delta subunit; Region: FlpD; pfam02662 191026015514 Heterodisulfide reductase, subunit A and related polyferredoxins [Energy production and conversion]; Region: HdrA; COG1148 191026015515 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 191026015516 Heterodisulfide reductase, subunit B [Energy production and conversion]; Region: HdrB; COG2048 191026015517 Cysteine-rich domain; Region: CCG; pfam02754 191026015518 Cysteine-rich domain; Region: CCG; pfam02754 191026015519 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 191026015520 4Fe-4S dicluster domain; Region: Fer4_17; pfam13534 191026015521 Cytochrome c554 and c-prime; Region: Cytochrome_C554; pfam13435 191026015522 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 191026015523 dimerization interface [polypeptide binding]; other site 191026015524 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 191026015525 PAS domain; Region: PAS_9; pfam13426 191026015526 putative active site [active] 191026015527 heme pocket [chemical binding]; other site 191026015528 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 191026015529 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 191026015530 dimer interface [polypeptide binding]; other site 191026015531 putative CheW interface [polypeptide binding]; other site 191026015532 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 191026015533 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 191026015534 ligand binding site [chemical binding]; other site 191026015535 L-cysteine desulfidase [Amino acid transport and metabolism]; Region: COG3681 191026015536 ADP-L-glycero-D-mannoheptose 6-epimerase (GME), extended (e) SDRs; Region: ADP_GME_SDR_e; cd05248 191026015537 ADP-L-glycero-D-manno-heptose-6-epimerase; Region: heptose_epim; TIGR02197 191026015538 NADP binding site [chemical binding]; other site 191026015539 homopentamer interface [polypeptide binding]; other site 191026015540 substrate binding site [chemical binding]; other site 191026015541 active site 191026015542 Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452 191026015543 Organic solvent tolerance protein; Region: OstA_C; pfam04453 191026015544 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 191026015545 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 191026015546 ATP binding site [chemical binding]; other site 191026015547 Mg2+ binding site [ion binding]; other site 191026015548 G-X-G motif; other site 191026015549 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 191026015550 ATP binding site [chemical binding]; other site 191026015551 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 191026015552 Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787 191026015553 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 191026015554 active site 191026015555 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 191026015556 dimer interface [polypeptide binding]; other site 191026015557 substrate binding site [chemical binding]; other site 191026015558 catalytic residues [active] 191026015559 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 191026015560 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 191026015561 Integrase core domain; Region: rve_3; pfam13683 191026015562 Transposase; Region: HTH_Tnp_1; cl17663 191026015563 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 191026015564 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 191026015565 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 191026015566 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 191026015567 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 191026015568 DNA binding residues [nucleotide binding] 191026015569 drug binding residues [chemical binding]; other site 191026015570 dimer interface [polypeptide binding]; other site 191026015571 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 191026015572 Multidrug resistance efflux transporter; Region: EmrE; pfam13536 191026015573 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 191026015574 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 191026015575 Hexamer interface [polypeptide binding]; other site 191026015576 Hexagonal pore residue; other site 191026015577 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 191026015578 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 191026015579 Hexamer interface [polypeptide binding]; other site 191026015580 Hexagonal pore residue; other site 191026015581 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 191026015582 putative catalytic cysteine [active] 191026015583 Pyruvate formate lyase 2 and related enzymes; Region: PFL2_DhaB_BssA; cd01677 191026015584 glycyl radical enzyme, PFL2/glycerol dehydratase family; Region: PFL2-3; TIGR01774 191026015585 dimer interface [polypeptide binding]; other site 191026015586 active site 191026015587 glycine loop; other site 191026015588 glycyl-radical enzyme activating protein family; Region: PFLE_PFLC; TIGR02494 191026015589 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 191026015590 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 191026015591 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 191026015592 Hexamer interface [polypeptide binding]; other site 191026015593 Hexagonal pore residue; other site 191026015594 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 191026015595 putative catalytic cysteine [active] 191026015596 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 191026015597 1,2-propanediol utilization protein A (PduA), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduA; cd07059 191026015598 Hexamer interface [polypeptide binding]; other site 191026015599 Putative hexagonal pore residue; other site 191026015600 propanediol utilization phosphotransacylase; Provisional; Region: PRK15070 191026015601 Propanediol utilisation protein PduL; Region: PduL; pfam06130 191026015602 Propanediol utilisation protein PduL; Region: PduL; pfam06130 191026015603 ethanolamine utilization protein EutJ; Provisional; Region: PRK15080 191026015604 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 191026015605 nucleotide binding site [chemical binding]; other site 191026015606 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 191026015607 ethanolamine utilization protein; Region: eut_hyp; TIGR02536 191026015608 Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614 191026015609 Hexamer/Pentamer interface [polypeptide binding]; other site 191026015610 central pore; other site 191026015611 PduT-like ethanolamine utilization protein; Region: eut_PduT; TIGR02526 191026015612 1,2-propanediol utilization protein T (PduT), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_PduT_repeat1; cd07053 191026015613 putative hexamer interface [polypeptide binding]; other site 191026015614 putative hexagonal pore; other site 191026015615 1,2-propanediol utilization protein T (PduT), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_PduT_repeat2; cd07054 191026015616 putative hexamer interface [polypeptide binding]; other site 191026015617 putative hexagonal pore; other site 191026015618 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 191026015619 1,2-propanediol utilization protein A (PduA), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduA; cd07059 191026015620 Hexamer interface [polypeptide binding]; other site 191026015621 Putative hexagonal pore residue; other site 191026015622 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 191026015623 1,3-propanediol dehydrogenase (PPD) catalyzes the reduction of 3-hydroxypropionaldehyde (3-HPA) to 1,3-propanediol in glycerol metabolism; Region: PDD; cd08180 191026015624 putative active site [active] 191026015625 metal binding site [ion binding]; metal-binding site 191026015626 Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512 191026015627 SLBB domain; Region: SLBB; pfam10531 191026015628 4Fe-4S dicluster domain; Region: Fer4_17; pfam13534 191026015629 RnfC Barrel sandwich hybrid domain; Region: RnfC_N; pfam13375 191026015630 PduT-like ethanolamine utilization protein; Region: eut_PduT; TIGR02526 191026015631 1,2-propanediol utilization protein T (PduT), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_PduT_repeat1; cd07053 191026015632 putative hexamer interface [polypeptide binding]; other site 191026015633 putative hexagonal pore; other site 191026015634 1,2-propanediol utilization protein T (PduT), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_PduT_repeat2; cd07054 191026015635 putative hexamer interface [polypeptide binding]; other site 191026015636 putative hexagonal pore; other site 191026015637 1,2-propanediol utilization protein U (PduU)/ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduU-EutS; cd07046 191026015638 putative hexamer interface [polypeptide binding]; other site 191026015639 putative hexagonal pore; other site 191026015640 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 191026015641 G1 box; other site 191026015642 GTP/Mg2+ binding site [chemical binding]; other site 191026015643 Switch I region; other site 191026015644 G3 box; other site 191026015645 Switch II region; other site 191026015646 G4 box; other site 191026015647 G5 box; other site 191026015648 Cache domain; Region: Cache_1; pfam02743 191026015649 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 191026015650 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 191026015651 dimerization interface [polypeptide binding]; other site 191026015652 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 191026015653 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 191026015654 Outer membrane efflux protein; Region: OEP; pfam02321 191026015655 Outer membrane efflux protein; Region: OEP; pfam02321 191026015656 Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999 191026015657 HlyD family secretion protein; Region: HlyD_3; pfam13437 191026015658 Protein of unknown function (DUF3347); Region: DUF3347; pfam11827 191026015659 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 191026015660 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 191026015661 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 191026015662 Ribonucleotide reductase, barrel domain; Region: Ribonuc_red_lgC; pfam02867 191026015663 TSCPD domain; Region: TSCPD; cl14834 191026015664 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 191026015665 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 191026015666 putative DNA binding site [nucleotide binding]; other site 191026015667 putative Zn2+ binding site [ion binding]; other site 191026015668 Methyltransferase domain; Region: Methyltransf_23; pfam13489 191026015669 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 191026015670 S-adenosylmethionine binding site [chemical binding]; other site 191026015671 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 191026015672 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 191026015673 metal binding site [ion binding]; metal-binding site 191026015674 active site 191026015675 I-site; other site 191026015676 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 191026015677 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 191026015678 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 191026015679 ATP binding site [chemical binding]; other site 191026015680 Mg2+ binding site [ion binding]; other site 191026015681 G-X-G motif; other site 191026015682 Protein of unknown function (DUF3478); Region: DUF3478; pfam11964 191026015683 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 191026015684 Domain of unknown function (DUF3412); Region: DUF3412; pfam11892 191026015685 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 191026015686 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 191026015687 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 191026015688 dimerization interface [polypeptide binding]; other site 191026015689 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 191026015690 dimer interface [polypeptide binding]; other site 191026015691 putative CheW interface [polypeptide binding]; other site 191026015692 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 191026015693 putative CheA interaction surface; other site 191026015694 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 191026015695 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 191026015696 PAS domain; Region: PAS_9; pfam13426 191026015697 putative active site [active] 191026015698 heme pocket [chemical binding]; other site 191026015699 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 191026015700 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 191026015701 dimer interface [polypeptide binding]; other site 191026015702 phosphorylation site [posttranslational modification] 191026015703 Response regulator receiver domain; Region: Response_reg; pfam00072 191026015704 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 191026015705 active site 191026015706 phosphorylation site [posttranslational modification] 191026015707 intermolecular recognition site; other site 191026015708 dimerization interface [polypeptide binding]; other site 191026015709 MarC family integral membrane protein; Region: MarC; cl00919 191026015710 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 191026015711 intersubunit interface [polypeptide binding]; other site 191026015712 active site 191026015713 Zn2+ binding site [ion binding]; other site 191026015714 Peptidase family M48; Region: Peptidase_M48; pfam01435 191026015715 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 191026015716 binding surface 191026015717 TPR motif; other site 191026015718 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 191026015719 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 191026015720 ring oligomerisation interface [polypeptide binding]; other site 191026015721 ATP/Mg binding site [chemical binding]; other site 191026015722 stacking interactions; other site 191026015723 hinge regions; other site 191026015724 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 191026015725 oligomerisation interface [polypeptide binding]; other site 191026015726 mobile loop; other site 191026015727 roof hairpin; other site 191026015728 Predicted transcriptional regulator [Transcription]; Region: COG2932 191026015729 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 191026015730 Catalytic site [active] 191026015731 Homeodomain-like domain; Region: HTH_23; pfam13384 191026015732 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 191026015733 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 191026015734 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 191026015735 putative active site [active] 191026015736 heme pocket [chemical binding]; other site 191026015737 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 191026015738 putative active site [active] 191026015739 heme pocket [chemical binding]; other site 191026015740 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 191026015741 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 191026015742 metal binding site [ion binding]; metal-binding site 191026015743 active site 191026015744 I-site; other site 191026015745 Predicted inhibitor of MCP methylation, homolog of CheC [Cell motility and secretion]; Region: COG1406 191026015746 Chemotaxis phosphatase CheX; Region: CheX; pfam13690 191026015747 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 191026015748 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 191026015749 active site 191026015750 HIGH motif; other site 191026015751 nucleotide binding site [chemical binding]; other site 191026015752 catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807 191026015753 KMSKS motif; other site 191026015754 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 191026015755 [FeFe] hydrogenase H-cluster maturation GTPase HydF; Region: GTP_HydF; TIGR03918 191026015756 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 191026015757 G1 box; other site 191026015758 GTP/Mg2+ binding site [chemical binding]; other site 191026015759 G2 box; other site 191026015760 Switch I region; other site 191026015761 G3 box; other site 191026015762 Switch II region; other site 191026015763 G4 box; other site 191026015764 G5 box; other site 191026015765 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 191026015766 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 191026015767 ligand binding site [chemical binding]; other site 191026015768 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 191026015769 dimerization interface [polypeptide binding]; other site 191026015770 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 191026015771 dimer interface [polypeptide binding]; other site 191026015772 phosphorylation site [posttranslational modification] 191026015773 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 191026015774 ATP binding site [chemical binding]; other site 191026015775 Mg2+ binding site [ion binding]; other site 191026015776 G-X-G motif; other site 191026015777 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 191026015778 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 191026015779 active site 191026015780 phosphorylation site [posttranslational modification] 191026015781 intermolecular recognition site; other site 191026015782 dimerization interface [polypeptide binding]; other site 191026015783 Response regulator receiver domain; Region: Response_reg; pfam00072 191026015784 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 191026015785 active site 191026015786 phosphorylation site [posttranslational modification] 191026015787 intermolecular recognition site; other site 191026015788 dimerization interface [polypeptide binding]; other site 191026015789 Hpt domain; Region: Hpt; pfam01627 191026015790 putative binding surface; other site 191026015791 active site 191026015792 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 191026015793 Sodium Bile acid symporter family; Region: SBF; pfam01758 191026015794 Flagellin N-methylase; Region: FliB; pfam03692 191026015795 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 191026015796 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 191026015797 pyridoxal 5'-phosphate binding site [chemical binding]; other site 191026015798 catalytic residue [active] 191026015799 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 191026015800 active site 191026015801 intersubunit interactions; other site 191026015802 catalytic residue [active] 191026015803 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 191026015804 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 191026015805 NMT1-like family; Region: NMT1_2; pfam13379 191026015806 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 191026015807 dimerization interface [polypeptide binding]; other site 191026015808 PAS domain S-box; Region: sensory_box; TIGR00229 191026015809 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 191026015810 putative active site [active] 191026015811 heme pocket [chemical binding]; other site 191026015812 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 191026015813 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 191026015814 putative active site [active] 191026015815 heme pocket [chemical binding]; other site 191026015816 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 191026015817 dimer interface [polypeptide binding]; other site 191026015818 phosphorylation site [posttranslational modification] 191026015819 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 191026015820 ATP binding site [chemical binding]; other site 191026015821 Mg2+ binding site [ion binding]; other site 191026015822 G-X-G motif; other site 191026015823 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 191026015824 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 191026015825 Walker A/P-loop; other site 191026015826 ATP binding site [chemical binding]; other site 191026015827 Q-loop/lid; other site 191026015828 ABC transporter signature motif; other site 191026015829 Walker B; other site 191026015830 D-loop; other site 191026015831 H-loop/switch region; other site 191026015832 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 191026015833 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 191026015834 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 191026015835 Walker A/P-loop; other site 191026015836 ATP binding site [chemical binding]; other site 191026015837 Q-loop/lid; other site 191026015838 ABC transporter signature motif; other site 191026015839 Walker B; other site 191026015840 D-loop; other site 191026015841 H-loop/switch region; other site 191026015842 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 191026015843 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 191026015844 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 191026015845 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 191026015846 dimer interface [polypeptide binding]; other site 191026015847 conserved gate region; other site 191026015848 putative PBP binding loops; other site 191026015849 ABC-ATPase subunit interface; other site 191026015850 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 191026015851 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 191026015852 dimer interface [polypeptide binding]; other site 191026015853 conserved gate region; other site 191026015854 putative PBP binding loops; other site 191026015855 ABC-ATPase subunit interface; other site 191026015856 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 191026015857 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_2; cd08498 191026015858 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 191026015859 dimerization interface [polypeptide binding]; other site 191026015860 nitrogen fixation negative regulator NifL; Region: nifL_nitrog; TIGR02938 191026015861 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 191026015862 putative active site [active] 191026015863 heme pocket [chemical binding]; other site 191026015864 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 191026015865 putative active site [active] 191026015866 heme pocket [chemical binding]; other site 191026015867 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 191026015868 dimer interface [polypeptide binding]; other site 191026015869 phosphorylation site [posttranslational modification] 191026015870 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 191026015871 ATP binding site [chemical binding]; other site 191026015872 Mg2+ binding site [ion binding]; other site 191026015873 G-X-G motif; other site 191026015874 Transcriptional regulator; Region: Rrf2; cl17282 191026015875 Rrf2 family protein; Region: rrf2_super; TIGR00738 191026015876 Response regulator receiver domain; Region: Response_reg; pfam00072 191026015877 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 191026015878 active site 191026015879 phosphorylation site [posttranslational modification] 191026015880 intermolecular recognition site; other site 191026015881 dimerization interface [polypeptide binding]; other site 191026015882 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 191026015883 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 191026015884 ATP binding site [chemical binding]; other site 191026015885 Mg2+ binding site [ion binding]; other site 191026015886 G-X-G motif; other site 191026015887 Response regulator receiver domain; Region: Response_reg; pfam00072 191026015888 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 191026015889 active site 191026015890 phosphorylation site [posttranslational modification] 191026015891 intermolecular recognition site; other site 191026015892 dimerization interface [polypeptide binding]; other site 191026015893 Response regulator receiver domain; Region: Response_reg; pfam00072 191026015894 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 191026015895 active site 191026015896 phosphorylation site [posttranslational modification] 191026015897 intermolecular recognition site; other site 191026015898 dimerization interface [polypeptide binding]; other site 191026015899 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 191026015900 Ligand Binding Site [chemical binding]; other site 191026015901 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 191026015902 Ligand Binding Site [chemical binding]; other site 191026015903 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 191026015904 Polysulphide reductase [Energy production and conversion]; Region: COG5557; cl17901 191026015905 Polysulphide reductase, NrfD; Region: NrfD; pfam03916 191026015906 hydrogenase 2 protein HybA; Provisional; Region: PRK10882 191026015907 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168 191026015908 heme-binding residues [chemical binding]; other site 191026015909 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168 191026015910 heme-binding residues [chemical binding]; other site 191026015911 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168 191026015912 heme-binding residues [chemical binding]; other site 191026015913 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168 191026015914 heme-binding residues [chemical binding]; other site 191026015915 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 191026015916 nucleoside/Zn binding site; other site 191026015917 dimer interface [polypeptide binding]; other site 191026015918 catalytic motif [active] 191026015919 Radical SAM superfamily; Region: Radical_SAM; pfam04055 191026015920 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 191026015921 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 191026015922 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 191026015923 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 191026015924 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 191026015925 active site 191026015926 DNA binding site [nucleotide binding] 191026015927 Int/Topo IB signature motif; other site 191026015928 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 191026015929 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 191026015930 This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798 191026015931 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 191026015932 DNA polymerase II large subunit; Validated; Region: PRK04023 191026015933 FOG: CBS domain [General function prediction only]; Region: COG0517 191026015934 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_17; cd04630 191026015935 Nitrogen regulatory protein P-II; Region: P-II; cl00412 191026015936 Nitrogen regulatory protein P-II; Region: P-II; smart00938 191026015937 Protein of unknown function (DUF1538); Region: DUF1538; pfam07556 191026015938 Protein of unknown function (DUF1538); Region: DUF1538; pfam07556 191026015939 Response regulator receiver domain; Region: Response_reg; pfam00072 191026015940 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 191026015941 active site 191026015942 phosphorylation site [posttranslational modification] 191026015943 intermolecular recognition site; other site 191026015944 dimerization interface [polypeptide binding]; other site 191026015945 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 191026015946 dimer interface [polypeptide binding]; other site 191026015947 phosphorylation site [posttranslational modification] 191026015948 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 191026015949 ATP binding site [chemical binding]; other site 191026015950 Mg2+ binding site [ion binding]; other site 191026015951 G-X-G motif; other site 191026015952 Response regulator receiver domain; Region: Response_reg; pfam00072 191026015953 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 191026015954 active site 191026015955 phosphorylation site [posttranslational modification] 191026015956 intermolecular recognition site; other site 191026015957 dimerization interface [polypeptide binding]; other site 191026015958 Response regulator receiver domain; Region: Response_reg; pfam00072 191026015959 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 191026015960 active site 191026015961 phosphorylation site [posttranslational modification] 191026015962 intermolecular recognition site; other site 191026015963 dimerization interface [polypeptide binding]; other site 191026015964 Response regulator receiver domain; Region: Response_reg; pfam00072 191026015965 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 191026015966 active site 191026015967 phosphorylation site [posttranslational modification] 191026015968 intermolecular recognition site; other site 191026015969 dimerization interface [polypeptide binding]; other site 191026015970 nitrogen fixation negative regulator NifL; Region: nifL_nitrog; TIGR02938 191026015971 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 191026015972 putative active site [active] 191026015973 heme pocket [chemical binding]; other site 191026015974 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 191026015975 dimer interface [polypeptide binding]; other site 191026015976 phosphorylation site [posttranslational modification] 191026015977 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 191026015978 ATP binding site [chemical binding]; other site 191026015979 Mg2+ binding site [ion binding]; other site 191026015980 G-X-G motif; other site 191026015981 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 191026015982 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 191026015983 active site 191026015984 phosphorylation site [posttranslational modification] 191026015985 intermolecular recognition site; other site 191026015986 dimerization interface [polypeptide binding]; other site 191026015987 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 191026015988 Walker A motif; other site 191026015989 ATP binding site [chemical binding]; other site 191026015990 Walker B motif; other site 191026015991 arginine finger; other site 191026015992 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 191026015993 Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823 191026015994 TSCPD domain; Region: TSCPD; cl14834 191026015995 putative metalloenzyme radical SAM/SPASM domain maturase; Region: rSAM_Geo_metal; TIGR04311 191026015996 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 191026015997 FeS/SAM binding site; other site 191026015998 Domain of unknown function (DUF4008); Region: DUF4008; pfam13186 191026015999 C-terminal peptidase (prc); Region: prc; TIGR00225 191026016000 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 191026016001 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 191026016002 Active site serine [active] 191026016003 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 191026016004 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 191026016005 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 191026016006 metal ion-dependent adhesion site (MIDAS); other site 191026016007 Tubulin like; Region: Tubulin_2; pfam13809 191026016008 AmmeMemoRadiSam system radical SAM enzyme; Region: AmmeMemoSam_rS; TIGR04337 191026016009 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 191026016010 FeS/SAM binding site; other site 191026016011 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 191026016012 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 191026016013 dimerization interface [polypeptide binding]; other site 191026016014 putative ATP binding site [chemical binding]; other site 191026016015 Protein of unknown function (DUF1318); Region: DUF1318; cl01547 191026016016 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 191026016017 Radical SAM superfamily; Region: Radical_SAM; pfam04055 191026016018 FeS/SAM binding site; other site 191026016019 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 191026016020 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 191026016021 dimer interface [polypeptide binding]; other site 191026016022 phosphorylation site [posttranslational modification] 191026016023 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 191026016024 ATP binding site [chemical binding]; other site 191026016025 Mg2+ binding site [ion binding]; other site 191026016026 G-X-G motif; other site 191026016027 EAL domain; Region: EAL; pfam00563 191026016028 Predicted signal transduction protein containing EAL and modified HD-GYP domains [Signal transduction mechanisms]; Region: COG3434 191026016029 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 191026016030 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 191026016031 23S rRNA interface [nucleotide binding]; other site 191026016032 L3 interface [polypeptide binding]; other site 191026016033 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 191026016034 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 191026016035 motif 1; other site 191026016036 active site 191026016037 motif 2; other site 191026016038 motif 3; other site 191026016039 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 191026016040 recombinase A; Provisional; Region: recA; PRK09354 191026016041 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 191026016042 hexamer interface [polypeptide binding]; other site 191026016043 Walker A motif; other site 191026016044 ATP binding site [chemical binding]; other site 191026016045 Walker B motif; other site 191026016046 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 191026016047 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 191026016048 Ligand Binding Site [chemical binding]; other site 191026016049 Domain of unknown function (DUF814); Region: DUF814; pfam05670 191026016050 Ca2+/Na+ antiporter [Inorganic ion transport and metabolism]; Region: ECM27; COG0530 191026016051 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 191026016052 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 191026016053 dipeptide/tripeptide permease B; Provisional; Region: PRK10207 191026016054 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 191026016055 putative substrate translocation pore; other site 191026016056 POT family; Region: PTR2; cl17359 191026016057 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 191026016058 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 191026016059 Tetraacyldisaccharide-1-P 4'-kinase [Cell envelope biogenesis, outer membrane]; Region: LpxK; COG1663 191026016060 Tetraacyldisaccharide-1-P 4'-kinase; Region: LpxK; pfam02606 191026016061 ribonuclease R; Region: RNase_R; TIGR02063 191026016062 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 191026016063 RNB domain; Region: RNB; pfam00773 191026016064 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 191026016065 RNA binding site [nucleotide binding]; other site 191026016066 Bacteriophage CI repressor helix-turn-helix domain; Region: Phage_CI_repr; pfam07022 191026016067 Predicted transcriptional regulator [Transcription]; Region: COG2932 191026016068 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 191026016069 Catalytic site [active] 191026016070 UPF0489 domain; Region: UPF0489; pfam12640 191026016071 ABC-type amino acid transport/signal transduction systems, periplasmic component/domain [Amino acid transport and metabolism / Signal transduction mechanisms]; Region: HisJ; COG0834 191026016072 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 191026016073 substrate binding pocket [chemical binding]; other site 191026016074 membrane-bound complex binding site; other site 191026016075 hinge residues; other site 191026016076 prolyl-tRNA synthetase, family II; Region: proS_fam_II; TIGR00409 191026016077 Galactose binding lectin domain; Region: Gal_Lectin; pfam02140 191026016078 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 191026016079 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 191026016080 substrate binding pocket [chemical binding]; other site 191026016081 membrane-bound complex binding site; other site 191026016082 hinge residues; other site 191026016083 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 191026016084 putative catalytic site [active] 191026016085 putative phosphate binding site [ion binding]; other site 191026016086 putative metal binding site [ion binding]; other site 191026016087 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 191026016088 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 191026016089 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 191026016090 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 191026016091 putative active site [active] 191026016092 heme pocket [chemical binding]; other site 191026016093 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 191026016094 dimer interface [polypeptide binding]; other site 191026016095 phosphorylation site [posttranslational modification] 191026016096 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 191026016097 ATP binding site [chemical binding]; other site 191026016098 Mg2+ binding site [ion binding]; other site 191026016099 G-X-G motif; other site 191026016100 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 191026016101 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 191026016102 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 191026016103 active site 191026016104 phosphorylation site [posttranslational modification] 191026016105 intermolecular recognition site; other site 191026016106 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 191026016107 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 191026016108 trimerization site [polypeptide binding]; other site 191026016109 active site 191026016110 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 191026016111 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 191026016112 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 191026016113 dimerization interface [polypeptide binding]; other site 191026016114 substrate binding pocket [chemical binding]; other site 191026016115 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; cl17497 191026016116 Protein of unknown function, DUF482; Region: DUF482; pfam04339 191026016117 Uncharacterized protein family (UPF0227); Region: UPF0227; cl14886 191026016118 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 191026016119 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 191026016120 Uncharacterized protein family UPF0052; Region: UPF0052; pfam01933 191026016121 phosphate binding site [ion binding]; other site 191026016122 putative substrate binding pocket [chemical binding]; other site 191026016123 dimer interface [polypeptide binding]; other site 191026016124 endonuclease IV; Provisional; Region: PRK01060 191026016125 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 191026016126 AP (apurinic/apyrimidinic) site pocket; other site 191026016127 DNA interaction; other site 191026016128 Metal-binding active site; metal-binding site 191026016129 Uncharacterized protein conserved in bacteria (DUF2325); Region: DUF2325; pfam10087 191026016130 PAS domain S-box; Region: sensory_box; TIGR00229 191026016131 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 191026016132 putative active site [active] 191026016133 heme pocket [chemical binding]; other site 191026016134 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 191026016135 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 191026016136 dimer interface [polypeptide binding]; other site 191026016137 phosphorylation site [posttranslational modification] 191026016138 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 191026016139 ATP binding site [chemical binding]; other site 191026016140 Mg2+ binding site [ion binding]; other site 191026016141 G-X-G motif; other site 191026016142 Response regulator receiver domain; Region: Response_reg; pfam00072 191026016143 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 191026016144 active site 191026016145 phosphorylation site [posttranslational modification] 191026016146 intermolecular recognition site; other site 191026016147 dimerization interface [polypeptide binding]; other site 191026016148 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 191026016149 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 191026016150 phosphate binding site [ion binding]; other site 191026016151 putative substrate binding pocket [chemical binding]; other site 191026016152 dimer interface [polypeptide binding]; other site 191026016153 HprK-related kinase B; Region: HprK_rel_B; TIGR04355 191026016154 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 191026016155 active site 191026016156 ATP-grasp enzyme, GAK system; Region: grasp_GAK; TIGR04356 191026016157 ATP-grasp domain; Region: ATP-grasp_4; cl17255 191026016158 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 191026016159 PhoU domain; Region: PhoU; pfam01895 191026016160 PhoU domain; Region: PhoU; pfam01895 191026016161 Phosphotransferase enzyme family; Region: APH; pfam01636 191026016162 amphi-Trp domain; Region: amphi-Trp; TIGR04354 191026016163 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 191026016164 XXXCH domain; Region: XXXCH_domain; TIGR04358 191026016165 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 191026016166 Zn2+ binding site [ion binding]; other site 191026016167 Mg2+ binding site [ion binding]; other site 191026016168 Transcriptional regulator [Transcription]; Region: LysR; COG0583 191026016169 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 191026016170 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 191026016171 dimerization interface [polypeptide binding]; other site 191026016172 substrate binding pocket [chemical binding]; other site 191026016173 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 191026016174 Protein of unknown function (DUF721); Region: DUF721; pfam05258 191026016175 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 191026016176 putative DNA binding site [nucleotide binding]; other site 191026016177 dimerization interface [polypeptide binding]; other site 191026016178 putative Zn2+ binding site [ion binding]; other site 191026016179 Methyltransferase domain; Region: Methyltransf_31; pfam13847 191026016180 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 191026016181 S-adenosylmethionine binding site [chemical binding]; other site 191026016182 Adenosylhomocysteinase; Provisional; Region: PTZ00075 191026016183 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 191026016184 homotetramer interface [polypeptide binding]; other site 191026016185 ligand binding site [chemical binding]; other site 191026016186 catalytic site [active] 191026016187 NAD binding site [chemical binding]; other site 191026016188 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 191026016189 DEAD-like helicases superfamily; Region: DEXDc; smart00487 191026016190 ATP binding site [chemical binding]; other site 191026016191 Mg++ binding site [ion binding]; other site 191026016192 motif III; other site 191026016193 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 191026016194 nucleotide binding region [chemical binding]; other site 191026016195 ATP-binding site [chemical binding]; other site 191026016196 RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399 191026016197 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042 191026016198 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 191026016199 aromatic amino acid transport protein; Region: araaP; TIGR00837 191026016200 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 191026016201 Aspartase; Region: Aspartase; cd01357 191026016202 active sites [active] 191026016203 tetramer interface [polypeptide binding]; other site 191026016204 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 191026016205 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 191026016206 putative active site [active] 191026016207 heme pocket [chemical binding]; other site 191026016208 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 191026016209 putative active site [active] 191026016210 heme pocket [chemical binding]; other site 191026016211 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 191026016212 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 191026016213 metal binding site [ion binding]; metal-binding site 191026016214 active site 191026016215 I-site; other site 191026016216 Predicted permeases [General function prediction only]; Region: RarD; COG2962 191026016217 Multidrug resistance efflux transporter; Region: EmrE; pfam13536 191026016218 DhnA-type fructose-1,6-bisphosphate aldolase and related enzymes [Carbohydrate transport and metabolism]; Region: FbaB; COG1830 191026016219 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 191026016220 putative active site; other site 191026016221 catalytic residue [active] 191026016222 Predicted alternative 3-dehydroquinate synthase [Amino acid transport and metabolism]; Region: COG1465 191026016223 3-dehydroquinate synthase; Provisional; Region: PRK02290 191026016224 Chorismate mutase type II; Region: CM_2; smart00830 191026016225 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 191026016226 Prephenate dehydratase; Region: PDT; pfam00800 191026016227 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 191026016228 putative L-Phe binding site [chemical binding]; other site 191026016229 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 191026016230 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 191026016231 hinge; other site 191026016232 active site 191026016233 arogenate dehydrogenase; Region: PLN02256 191026016234 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 191026016235 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 191026016236 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 191026016237 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 191026016238 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 191026016239 glutamine binding [chemical binding]; other site 191026016240 catalytic triad [active] 191026016241 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 191026016242 anthranilate phosphoribosyltransferase; Region: trpD; TIGR01245 191026016243 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 191026016244 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 191026016245 active site 191026016246 ribulose/triose binding site [chemical binding]; other site 191026016247 phosphate binding site [ion binding]; other site 191026016248 substrate (anthranilate) binding pocket [chemical binding]; other site 191026016249 product (indole) binding pocket [chemical binding]; other site 191026016250 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 191026016251 active site 191026016252 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 191026016253 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 191026016254 pyridoxal 5'-phosphate binding site [chemical binding]; other site 191026016255 catalytic residue [active] 191026016256 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 191026016257 substrate binding site [chemical binding]; other site 191026016258 active site 191026016259 catalytic residues [active] 191026016260 heterodimer interface [polypeptide binding]; other site 191026016261 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 191026016262 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 191026016263 dimerization interface [polypeptide binding]; other site 191026016264 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 191026016265 dimer interface [polypeptide binding]; other site 191026016266 phosphorylation site [posttranslational modification] 191026016267 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 191026016268 ATP binding site [chemical binding]; other site 191026016269 Mg2+ binding site [ion binding]; other site 191026016270 G-X-G motif; other site 191026016271 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 191026016272 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 191026016273 active site 191026016274 phosphorylation site [posttranslational modification] 191026016275 intermolecular recognition site; other site 191026016276 dimerization interface [polypeptide binding]; other site 191026016277 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 191026016278 DNA binding site [nucleotide binding] 191026016279 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 191026016280 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 191026016281 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 191026016282 HlyD family secretion protein; Region: HlyD_3; pfam13437 191026016283 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 191026016284 Protein export membrane protein; Region: SecD_SecF; cl14618 191026016285 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 191026016286 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 191026016287 putative active site [active] 191026016288 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 191026016289 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 191026016290 Flagellar hook capping protein [Cell motility and secretion]; Region: FlgD; COG1843 191026016291 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 191026016292 flagellar hook protein FlgE; Validated; Region: flgE; PRK05841 191026016293 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 191026016294 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 191026016295 flagellin; Provisional; Region: PRK12802 191026016296 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 191026016297 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 191026016298 ribonuclease III; Reviewed; Region: rnc; PRK00102 191026016299 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 191026016300 dimerization interface [polypeptide binding]; other site 191026016301 active site 191026016302 metal binding site [ion binding]; metal-binding site 191026016303 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 191026016304 dsRNA binding site [nucleotide binding]; other site 191026016305 acetyl coenzyme A synthetase (ADP forming), alpha domain; Region: AcCoA-syn-alpha; TIGR02717 191026016306 CoA binding domain; Region: CoA_binding_2; pfam13380 191026016307 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 191026016308 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 191026016309 BioD-like N-terminal domain of phosphotransacetylase [General function prediction only]; Region: Pta; COG0857 191026016310 DRTGG domain; Region: DRTGG; pfam07085 191026016311 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 191026016312 ABC-type amino acid transport/signal transduction systems, periplasmic component/domain [Amino acid transport and metabolism / Signal transduction mechanisms]; Region: HisJ; COG0834 191026016313 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 191026016314 substrate binding pocket [chemical binding]; other site 191026016315 membrane-bound complex binding site; other site 191026016316 hinge residues; other site 191026016317 dihydrolipoamide dehydrogenase; Region: lipoamide_DH; TIGR01350 191026016318 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 191026016319 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 191026016320 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 191026016321 glycine dehydrogenase subunit 2; Validated; Region: PRK04366 191026016322 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 191026016323 catalytic residue [active] 191026016324 Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403 191026016325 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 191026016326 tetramer interface [polypeptide binding]; other site 191026016327 pyridoxal 5'-phosphate binding site [chemical binding]; other site 191026016328 catalytic residue [active] 191026016329 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 191026016330 lipoyl attachment site [posttranslational modification]; other site 191026016331 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 191026016332 S-adenosylmethionine binding site [chemical binding]; other site 191026016333 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 191026016334 nickel responsive regulator; Provisional; Region: PRK04460 191026016335 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 191026016336 NikR C terminal nickel binding domain; Region: NikR_C; pfam08753 191026016337 putative GTP cyclohydrolase; Provisional; Region: PRK13674 191026016338 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 191026016339 active site residue [active] 191026016340 Protein of unknown function (DUF1499); Region: DUF1499; cl01841 191026016341 Transcriptional regulator; Region: Rrf2; cl17282 191026016342 Rrf2 family protein; Region: rrf2_super; TIGR00738 191026016343 Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl17341 191026016344 Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509 191026016345 D-xylose transporter XylE; Provisional; Region: xylE; PRK10077 191026016346 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 191026016347 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 191026016348 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 191026016349 Walker A motif; other site 191026016350 ATP binding site [chemical binding]; other site 191026016351 Walker B motif; other site 191026016352 arginine finger; other site 191026016353 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 191026016354 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 191026016355 Memo (mediator of ErbB2-driven cell motility) is co-precipitated with the C terminus of ErbB2, a protein involved in cell motility; Region: MEMO_like; cd07361 191026016356 putative ligand binding pocket/active site [active] 191026016357 putative metal binding site [ion binding]; other site 191026016358 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 191026016359 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 191026016360 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 191026016361 AAA domain; Region: AAA_26; pfam13500 191026016362 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 191026016363 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 191026016364 adenosylmethionine-8-amino-7-oxononanoate transaminase; Region: bioA; TIGR00508 191026016365 inhibitor-cofactor binding pocket; inhibition site 191026016366 pyridoxal 5'-phosphate binding site [chemical binding]; other site 191026016367 catalytic residue [active] 191026016368 biotin synthase; Region: bioB; TIGR00433 191026016369 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 191026016370 Flagellar protein YcgR; Region: YcgR_2; pfam12945 191026016371 PilZ domain; Region: PilZ; pfam07238 191026016372 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 191026016373 binding surface 191026016374 TPR motif; other site 191026016375 TPR repeat; Region: TPR_11; pfam13414 191026016376 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 191026016377 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 191026016378 Walker A/P-loop; other site 191026016379 ATP binding site [chemical binding]; other site 191026016380 Q-loop/lid; other site 191026016381 ABC transporter signature motif; other site 191026016382 Walker B; other site 191026016383 D-loop; other site 191026016384 H-loop/switch region; other site 191026016385 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 191026016386 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 191026016387 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 191026016388 Walker A/P-loop; other site 191026016389 ATP binding site [chemical binding]; other site 191026016390 Q-loop/lid; other site 191026016391 ABC transporter signature motif; other site 191026016392 Walker B; other site 191026016393 D-loop; other site 191026016394 H-loop/switch region; other site 191026016395 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 191026016396 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 191026016397 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 191026016398 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 191026016399 dimer interface [polypeptide binding]; other site 191026016400 conserved gate region; other site 191026016401 putative PBP binding loops; other site 191026016402 ABC-ATPase subunit interface; other site 191026016403 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 191026016404 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 191026016405 dimer interface [polypeptide binding]; other site 191026016406 conserved gate region; other site 191026016407 putative PBP binding loops; other site 191026016408 ABC-ATPase subunit interface; other site 191026016409 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_2; cd08498 191026016410 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 191026016411 radical SAM family uncharacterized protein; Region: rSAM_fuse_unch; TIGR03960 191026016412 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 191026016413 FeS/SAM binding site; other site 191026016414 radical SAM-linked protein; Region: sam_1_link_chp; TIGR03936 191026016415 Uncharacterized protein conserved in bacteria (DUF2344); Region: DUF2344; pfam10105 191026016416 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 191026016417 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 191026016418 acetyl-CoA synthetase; Provisional; Region: PRK00174 191026016419 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 191026016420 active site 191026016421 CoA binding site [chemical binding]; other site 191026016422 acyl-activating enzyme (AAE) consensus motif; other site 191026016423 AMP binding site [chemical binding]; other site 191026016424 acetate binding site [chemical binding]; other site 191026016425 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 191026016426 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 191026016427 putative active site [active] 191026016428 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 191026016429 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 191026016430 pyridoxal 5'-phosphate binding site [chemical binding]; other site 191026016431 homodimer interface [polypeptide binding]; other site 191026016432 catalytic residue [active] 191026016433 hypothetical protein; Provisional; Region: PRK11568 191026016434 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 191026016435 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 191026016436 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 191026016437 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 191026016438 PilZ domain; Region: PilZ; pfam07238 191026016439 Predicted exonuclease [DNA replication, recombination, and repair]; Region: COG3359 191026016440 RNase_H superfamily; Region: RNase_H_2; pfam13482 191026016441 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 191026016442 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 191026016443 ATP binding site [chemical binding]; other site 191026016444 Mg++ binding site [ion binding]; other site 191026016445 motif III; other site 191026016446 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 191026016447 nucleotide binding region [chemical binding]; other site 191026016448 ATP-binding site [chemical binding]; other site 191026016449 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 191026016450 MiaB-like tRNA modifying enzyme; Region: MiaB-like-C; TIGR01579 191026016451 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 191026016452 FeS/SAM binding site; other site 191026016453 hypothetical protein; Provisional; Region: PRK11820 191026016454 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 191026016455 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 191026016456 hypothetical protein; Provisional; Region: PRK04323 191026016457 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 191026016458 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 191026016459 catalytic site [active] 191026016460 G-X2-G-X-G-K; other site 191026016461 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 191026016462 active site 191026016463 dimer interface [polypeptide binding]; other site 191026016464 Tetratricopeptide repeat; Region: TPR_12; pfam13424 191026016465 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 191026016466 binding surface 191026016467 TPR motif; other site 191026016468 Tetratricopeptide repeat; Region: TPR_12; pfam13424 191026016469 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 191026016470 DHH family; Region: DHH; pfam01368 191026016471 DHHA1 domain; Region: DHHA1; pfam02272 191026016472 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 191026016473 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 191026016474 dimerization interface [polypeptide binding]; other site 191026016475 PAS fold; Region: PAS_4; pfam08448 191026016476 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 191026016477 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 191026016478 dimer interface [polypeptide binding]; other site 191026016479 putative CheW interface [polypeptide binding]; other site 191026016480 Protein of unknown function (DUF4242); Region: DUF4242; pfam14026 191026016481 lipoyl synthase; Provisional; Region: PRK05481 191026016482 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 191026016483 FeS/SAM binding site; other site 191026016484 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 191026016485 Mitochondrial small ribosomal subunit Rsm22; Region: Rsm22; cl17847 191026016486 Uncharacterized metal-binding protein [General function prediction only]; Region: COG3894 191026016487 Cobalt chelatase (CbiK); Region: CbiK; pfam06180 191026016488 Class II Chelatase: a family of ATP-independent monomeric or homodimeric enzymes that catalyze the insertion of metal into protoporphyrin rings. This family includes protoporphyrin IX ferrochelatase (HemH), sirohydrochlorin ferrochelatase (SirB) and the...; Region: Chelatase_Class_II; cl02784 191026016489 active site 191026016490 Class II Chelatase: a family of ATP-independent monomeric or homodimeric enzymes that catalyze the insertion of metal into protoporphyrin rings. This family includes protoporphyrin IX ferrochelatase (HemH), sirohydrochlorin ferrochelatase (SirB) and the...; Region: Chelatase_Class_II; cl02784 191026016491 active site 191026016492 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 191026016493 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 191026016494 ATP binding site [chemical binding]; other site 191026016495 Mg2+ binding site [ion binding]; other site 191026016496 G-X-G motif; other site 191026016497 CheW-like domain; Region: CheW; pfam01584 191026016498 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 191026016499 putative binding surface; other site 191026016500 active site 191026016501 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 191026016502 Response regulator receiver domain; Region: Response_reg; pfam00072 191026016503 active site 191026016504 phosphorylation site [posttranslational modification] 191026016505 intermolecular recognition site; other site 191026016506 dimerization interface [polypeptide binding]; other site 191026016507 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 191026016508 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 191026016509 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 191026016510 active site 191026016511 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 191026016512 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 191026016513 nudix motif; other site 191026016514 glycogen synthase; Provisional; Region: glgA; PRK00654 191026016515 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 191026016516 ADP-binding pocket [chemical binding]; other site 191026016517 homodimer interface [polypeptide binding]; other site 191026016518 glycogen branching enzyme; Provisional; Region: PRK12313 191026016519 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 191026016520 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 191026016521 active site 191026016522 catalytic site [active] 191026016523 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 191026016524 4-hydroxythreonine-4-phosphate dehydrogenase; Region: pdxA; TIGR00557 191026016525 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 191026016526 D,D-heptose 1,7-bisphosphate phosphatase; Validated; Region: PRK08942 191026016527 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 191026016528 active site 191026016529 motif I; other site 191026016530 motif II; other site 191026016531 TPR repeat; Region: TPR_11; pfam13414 191026016532 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 191026016533 TPR motif; other site 191026016534 binding surface 191026016535 TPR repeat; Region: TPR_11; pfam13414 191026016536 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 191026016537 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988 191026016538 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 191026016539 catalytic site [active] 191026016540 subunit interface [polypeptide binding]; other site 191026016541 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 191026016542 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 191026016543 Ligand binding site; other site 191026016544 oligomer interface; other site 191026016545 3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749 191026016546 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 191026016547 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 191026016548 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 191026016549 ATP-grasp domain; Region: ATP-grasp_4; cl17255 191026016550 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 191026016551 Dissimilatory sulfite reductase (desulfoviridin), gamma subunit [Inorganic ion transport and metabolism]; Region: DsrC; COG2920 191026016552 DsrC like protein; Region: DsrC; pfam04358 191026016553 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 191026016554 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 191026016555 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 191026016556 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 191026016557 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 191026016558 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 191026016559 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 191026016560 acyl-activating enzyme (AAE) consensus motif; other site 191026016561 AMP binding site [chemical binding]; other site 191026016562 active site 191026016563 CoA binding site [chemical binding]; other site 191026016564 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 191026016565 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 191026016566 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 191026016567 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 191026016568 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 191026016569 dimerization interface [polypeptide binding]; other site 191026016570 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 191026016571 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 191026016572 dimer interface [polypeptide binding]; other site 191026016573 putative CheW interface [polypeptide binding]; other site 191026016574 Cache domain; Region: Cache_1; pfam02743 191026016575 PAS domain; Region: PAS_9; pfam13426 191026016576 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 191026016577 putative active site [active] 191026016578 heme pocket [chemical binding]; other site 191026016579 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 191026016580 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 191026016581 dimer interface [polypeptide binding]; other site 191026016582 putative CheW interface [polypeptide binding]; other site 191026016583 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 191026016584 Response regulator receiver domain; Region: Response_reg; pfam00072 191026016585 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 191026016586 active site 191026016587 phosphorylation site [posttranslational modification] 191026016588 intermolecular recognition site; other site 191026016589 dimerization interface [polypeptide binding]; other site 191026016590 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 191026016591 dimer interface [polypeptide binding]; other site 191026016592 active site 191026016593 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 191026016594 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 191026016595 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 191026016596 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 191026016597 putative active site [active] 191026016598 heme pocket [chemical binding]; other site 191026016599 PAS domain; Region: PAS; smart00091 191026016600 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 191026016601 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 191026016602 dimer interface [polypeptide binding]; other site 191026016603 phosphorylation site [posttranslational modification] 191026016604 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 191026016605 ATP binding site [chemical binding]; other site 191026016606 Mg2+ binding site [ion binding]; other site 191026016607 G-X-G motif; other site 191026016608 flagellin; Provisional; Region: PRK12804 191026016609 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 191026016610 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 191026016611 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 191026016612 isocitrate dehydrogenase; Validated; Region: PRK07362 191026016613 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 191026016614 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 191026016615 HlyD family secretion protein; Region: HlyD_3; pfam13437 191026016616 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 191026016617 aspartate aminotransferase; Provisional; Region: PRK05764 191026016618 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 191026016619 pyridoxal 5'-phosphate binding site [chemical binding]; other site 191026016620 homodimer interface [polypeptide binding]; other site 191026016621 catalytic residue [active] 191026016622 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 191026016623 Glutamine amidotransferase class-I; Region: GATase; pfam00117 191026016624 glutamine binding [chemical binding]; other site 191026016625 catalytic triad [active] 191026016626 aminodeoxychorismate synthase, component I, clade 2; Region: PabB-clade2; TIGR01824 191026016627 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 191026016628 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 191026016629 homodimer interface [polypeptide binding]; other site 191026016630 substrate-cofactor binding pocket; other site 191026016631 Aminotransferase class IV; Region: Aminotran_4; pfam01063 191026016632 pyridoxal 5'-phosphate binding site [chemical binding]; other site 191026016633 catalytic residue [active] 191026016634 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 191026016635 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 191026016636 active site 191026016637 HIGH motif; other site 191026016638 dimer interface [polypeptide binding]; other site 191026016639 KMSKS motif; other site 191026016640 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 191026016641 Peptidase family M50; Region: Peptidase_M50; pfam02163 191026016642 active site 191026016643 putative substrate binding region [chemical binding]; other site 191026016644 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 191026016645 active site 191026016646 phosphorylation site [posttranslational modification] 191026016647 intermolecular recognition site; other site 191026016648 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 191026016649 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 191026016650 Ligand Binding Site [chemical binding]; other site 191026016651 TIGR00269 family protein; Region: TIGR00269 191026016652 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 191026016653 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 191026016654 active site 191026016655 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 191026016656 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 191026016657 RNase E interface [polypeptide binding]; other site 191026016658 trimer interface [polypeptide binding]; other site 191026016659 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 191026016660 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 191026016661 RNase E interface [polypeptide binding]; other site 191026016662 trimer interface [polypeptide binding]; other site 191026016663 active site 191026016664 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 191026016665 putative nucleic acid binding region [nucleotide binding]; other site 191026016666 G-X-X-G motif; other site 191026016667 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 191026016668 RNA binding site [nucleotide binding]; other site 191026016669 domain interface; other site 191026016670 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 191026016671 16S/18S rRNA binding site [nucleotide binding]; other site 191026016672 S13e-L30e interaction site [polypeptide binding]; other site 191026016673 25S rRNA binding site [nucleotide binding]; other site 191026016674 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 191026016675 tRNA pseudouridine(55) synthase; Region: TruB; TIGR00431 191026016676 RNA binding site [nucleotide binding]; other site 191026016677 active site 191026016678 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 191026016679 DHH family; Region: DHH; pfam01368 191026016680 DHHA1 domain; Region: DHHA1; pfam02272 191026016681 Ribosome-binding factor A; Region: RBFA; pfam02033 191026016682 Protein of unknown function (DUF503); Region: DUF503; pfam04456 191026016683 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 191026016684 translation initiation factor IF-2; Region: IF-2; TIGR00487 191026016685 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 191026016686 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 191026016687 G1 box; other site 191026016688 putative GEF interaction site [polypeptide binding]; other site 191026016689 GTP/Mg2+ binding site [chemical binding]; other site 191026016690 Switch I region; other site 191026016691 G2 box; other site 191026016692 G3 box; other site 191026016693 Switch II region; other site 191026016694 G4 box; other site 191026016695 G5 box; other site 191026016696 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 191026016697 Translation-initiation factor 2; Region: IF-2; pfam11987 191026016698 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 191026016699 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cl00189 191026016700 putative RNA binding cleft [nucleotide binding]; other site 191026016701 transcription elongation factor NusA; Validated; Region: nusA; PRK09202 191026016702 NusA N-terminal domain; Region: NusA_N; pfam08529 191026016703 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 191026016704 RNA binding site [nucleotide binding]; other site 191026016705 homodimer interface [polypeptide binding]; other site 191026016706 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 191026016707 G-X-X-G motif; other site 191026016708 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 191026016709 G-X-X-G motif; other site 191026016710 ribosome maturation protein RimP; Reviewed; Region: PRK00092 191026016711 Sm and related proteins; Region: Sm_like; cl00259 191026016712 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 191026016713 putative oligomer interface [polypeptide binding]; other site 191026016714 putative RNA binding site [nucleotide binding]; other site 191026016715 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgG; COG4786 191026016716 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 191026016717 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 191026016718 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693 191026016719 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 191026016720 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 191026016721 SAF-like; Region: SAF_2; pfam13144 191026016722 flagella basal body P-ring formation protein FlgA; Region: flgA_cterm; TIGR03170 191026016723 flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK12696 191026016724 Flagellar L-ring protein; Region: FlgH; pfam02107 191026016725 flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303 191026016726 flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622 191026016727 Rod binding protein; Region: Rod-binding; cl01626 191026016728 FlgN protein; Region: FlgN; pfam05130 191026016729 flagellar hook-associated protein FlgK; Region: flgK_ends; TIGR02492 191026016730 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK08471 191026016731 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 191026016732 flagellar hook-associated protein FlgL; Provisional; Region: flgL; PRK12718 191026016733 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 191026016734 Global regulator protein family; Region: CsrA; pfam02599 191026016735 flagellar assembly protein FliW; Provisional; Region: PRK13285 191026016736 flagellar biosynthesis anti-sigma factor FlgM; Region: FlgM_jcvi; TIGR03824 191026016737 NAD kinase [Coenzyme metabolism]; Region: nadF; COG0061 191026016738 ATP-NAD kinase; Region: NAD_kinase; pfam01513 191026016739 Protein of unknown function DUF89; Region: DUF89; cl15397 191026016740 MltA specific insert domain; Region: MltA; smart00925 191026016741 3D domain; Region: 3D; pfam06725 191026016742 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 191026016743 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 191026016744 GatB domain; Region: GatB_Yqey; smart00845 191026016745 Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]; Region: COG0182; cl00348 191026016746 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 191026016747 GTP-binding protein Der; Reviewed; Region: PRK00093 191026016748 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 191026016749 G1 box; other site 191026016750 GTP/Mg2+ binding site [chemical binding]; other site 191026016751 Switch I region; other site 191026016752 G2 box; other site 191026016753 Switch II region; other site 191026016754 G3 box; other site 191026016755 G4 box; other site 191026016756 G5 box; other site 191026016757 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 191026016758 G1 box; other site 191026016759 GTP/Mg2+ binding site [chemical binding]; other site 191026016760 Switch I region; other site 191026016761 G2 box; other site 191026016762 G3 box; other site 191026016763 Switch II region; other site 191026016764 G4 box; other site 191026016765 G5 box; other site 191026016766 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 191026016767 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 191026016768 active site 191026016769 phosphorylation site [posttranslational modification] 191026016770 intermolecular recognition site; other site 191026016771 dimerization interface [polypeptide binding]; other site 191026016772 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 191026016773 DNA binding residues [nucleotide binding] 191026016774 dimerization interface [polypeptide binding]; other site 191026016775 integrase; Provisional; Region: PRK09692 191026016776 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 191026016777 active site 191026016778 Int/Topo IB signature motif; other site 191026016779 Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; cl17523 191026016780 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 191026016781 non-specific DNA binding site [nucleotide binding]; other site 191026016782 salt bridge; other site 191026016783 sequence-specific DNA binding site [nucleotide binding]; other site 191026016784 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 191026016785 non-specific DNA binding site [nucleotide binding]; other site 191026016786 salt bridge; other site 191026016787 sequence-specific DNA binding site [nucleotide binding]; other site 191026016788 The accessory protein CooC, which contains a nucleotide-binding domain (P-loop) near the N-terminus, participates in the maturation of the nickel center of carbon monoxide dehydrogenase (CODH). CODH from Rhodospirillum rubrum catalyzes the reversible...; Region: CooC; cd02034 191026016789 P-loop; other site 191026016790 P-type conjugative transfer ATPase TrbB; Region: TrbB_P; TIGR02782 191026016791 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 191026016792 ATP binding site [chemical binding]; other site 191026016793 Walker A motif; other site 191026016794 hexamer interface [polypeptide binding]; other site 191026016795 Walker B motif; other site 191026016796 TrbC/VIRB2 family; Region: TrbC; pfam04956 191026016797 conjugal transfer protein TrbD; Provisional; Region: PRK13823 191026016798 conjugal transfer protein TrbE; Provisional; Region: PRK13891 191026016799 CagE, TrbE, VirB family, component of type IV transporter system; Region: CagE_TrbE_VirB; pfam03135 191026016800 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 191026016801 Walker A/P-loop; other site 191026016802 ATP binding site [chemical binding]; other site 191026016803 conjugal transfer protein TrbJ; Provisional; Region: PRK13874; cl02193 191026016804 conjugal transfer protein TrbJ; Provisional; Region: PRK13874; cl02193 191026016805 TrbL/VirB6 plasmid conjugal transfer protein; Region: TrbL; cl01503 191026016806 VirB8 protein; Region: VirB8; cl01500 191026016807 VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cd06911 191026016808 VirB7 interaction site; other site 191026016809 conjugal transfer protein TrbH; Provisional; Region: PRK13883 191026016810 Toxin co-regulated pilus biosynthesis protein Q; Region: TcpQ; pfam10671 191026016811 type IVB pilus formation outer membrane protein, R64 PilN family; Region: pilus_B_mal_scr; TIGR02520 191026016812 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 191026016813 Pilin accessory protein (PilO); Region: PAP_PilO; pfam06864 191026016814 Type IV pilus biogenesis; Region: Pilus_PilP; pfam11356 191026016815 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 191026016816 Walker A motif; other site 191026016817 ATP binding site [chemical binding]; other site 191026016818 Walker B motif; other site 191026016819 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 191026016820 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 191026016821 PilS N terminal; Region: PilS; pfam08805 191026016822 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 191026016823 Walker A motif; other site 191026016824 ATP binding site [chemical binding]; other site 191026016825 Walker B motif; other site 191026016826 PilM; Region: PilM; pfam07419 191026016827 Bacterial shufflon protein, N-terminal constant region; Region: Shufflon_N; pfam04917 191026016828 Bacterial conjugation TrbI-like protein; Region: TrbI; cl04242 191026016829 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 191026016830 Walker A motif; other site 191026016831 ATP binding site [chemical binding]; other site 191026016832 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 191026016833 Walker B motif; other site 191026016834 conjugative transfer signal peptidase TraF; Region: TraF_Ti; TIGR02771 191026016835 conjugal transfer pilin processing protease TraF; Provisional; Region: PRK13838 191026016836 DNA topoisomerase III; Provisional; Region: PRK07726 191026016837 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 191026016838 active site 191026016839 putative interdomain interaction site [polypeptide binding]; other site 191026016840 putative metal-binding site [ion binding]; other site 191026016841 putative nucleotide binding site [chemical binding]; other site 191026016842 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 191026016843 domain I; other site 191026016844 DNA binding groove [nucleotide binding] 191026016845 phosphate binding site [ion binding]; other site 191026016846 domain II; other site 191026016847 domain III; other site 191026016848 nucleotide binding site [chemical binding]; other site 191026016849 catalytic site [active] 191026016850 domain IV; other site 191026016851 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 191026016852 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 191026016853 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: HicB; COG4226 191026016854 HicB family; Region: HicB; pfam05534 191026016855 Antirestriction protein [DNA replication, recombination, and repair]; Region: COG4227 191026016856 Domain of unknown function (DUF1738); Region: DUF1738; pfam08401 191026016857 Protein of unknown function, DUF462; Region: DUF462; cl01190 191026016858 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4643 191026016859 TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029 191026016860 active site 191026016861 metal binding site [ion binding]; metal-binding site 191026016862 interdomain interaction site; other site 191026016863 Cytidylate kinase-like family; Region: Cytidylate_kin2; pfam13189 191026016864 putative transporter; Provisional; Region: PRK11660 191026016865 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 191026016866 Sulfate transporter family; Region: Sulfate_transp; pfam00916 191026016867 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 191026016868 Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432 191026016869 conjugal transfer relaxosome component TraJ; Provisional; Region: PRK13877 191026016870 Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; pfam09669 191026016871 helicase superfamily c-terminal domain; Region: HELICc; smart00490 191026016872 ATP-binding site [chemical binding]; other site 191026016873 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 191026016874 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 191026016875 active site 191026016876 phosphorylation site [posttranslational modification] 191026016877 intermolecular recognition site; other site 191026016878 CheB methylesterase; Region: CheB_methylest; pfam01339 191026016879 HEAT repeats; Region: HEAT_2; pfam13646 191026016880 HEAT repeats; Region: HEAT_2; pfam13646 191026016881 HEAT repeats; Region: HEAT_2; pfam13646 191026016882 HEAT repeats; Region: HEAT_2; pfam13646 191026016883 HEAT repeats; Region: HEAT_2; pfam13646 191026016884 HEAT repeats; Region: HEAT_2; pfam13646 191026016885 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 191026016886 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 191026016887 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 191026016888 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 191026016889 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 191026016890 P-loop; other site 191026016891 Magnesium ion binding site [ion binding]; other site 191026016892 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 191026016893 Magnesium ion binding site [ion binding]; other site 191026016894 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 191026016895 Response regulator receiver domain; Region: Response_reg; pfam00072 191026016896 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 191026016897 active site 191026016898 phosphorylation site [posttranslational modification] 191026016899 intermolecular recognition site; other site 191026016900 dimerization interface [polypeptide binding]; other site 191026016901 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 191026016902 putative binding surface; other site 191026016903 active site 191026016904 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 191026016905 putative binding surface; other site 191026016906 active site 191026016907 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 191026016908 putative binding surface; other site 191026016909 active site 191026016910 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 191026016911 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 191026016912 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 191026016913 ATP binding site [chemical binding]; other site 191026016914 Mg2+ binding site [ion binding]; other site 191026016915 G-X-G motif; other site 191026016916 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 191026016917 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 191026016918 Tetratricopeptide repeat; Region: TPR_6; pfam13174 191026016919 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 191026016920 DNA protecting protein DprA; Region: dprA; TIGR00732 191026016921 HDOD domain; Region: HDOD; pfam08668 191026016922 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 191026016923 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 191026016924 active site 191026016925 phosphorylation site [posttranslational modification] 191026016926 intermolecular recognition site; other site 191026016927 dimerization interface [polypeptide binding]; other site 191026016928 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 191026016929 metal binding site [ion binding]; metal-binding site 191026016930 active site 191026016931 I-site; other site 191026016932 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 191026016933 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 191026016934 active site 191026016935 Int/Topo IB signature motif; other site 191026016936 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 191026016937 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 191026016938 FMN binding site [chemical binding]; other site 191026016939 substrate binding site [chemical binding]; other site 191026016940 putative catalytic residue [active] 191026016941 Predicted dehydrogenase [General function prediction only]; Region: COG0579 191026016942 hydroxyglutarate oxidase; Provisional; Region: PRK11728 191026016943 double-strand break repair protein AddB, alphaproteobacterial type; Region: addB_alphas; TIGR02786 191026016944 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 191026016945 ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains) [DNA replication, recombination, and repair]; Region: RecB; COG1074 191026016946 Family description; Region: UvrD_C_2; pfam13538 191026016947 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 191026016948 EamA-like transporter family; Region: EamA; pfam00892 191026016949 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 191026016950 EamA-like transporter family; Region: EamA; pfam00892 191026016951 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 191026016952 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 191026016953 RNA binding surface [nucleotide binding]; other site 191026016954 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 191026016955 active site 191026016956 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 191026016957 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 191026016958 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 191026016959 P loop; other site 191026016960 GTP binding site [chemical binding]; other site 191026016961 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 191026016962 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318 191026016963 putative dimer interface [polypeptide binding]; other site 191026016964 putative anticodon binding site; other site 191026016965 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 191026016966 homodimer interface [polypeptide binding]; other site 191026016967 motif 1; other site 191026016968 motif 2; other site 191026016969 active site 191026016970 motif 3; other site 191026016971 GyrI-like small molecule binding domain; Region: GyrI-like; pfam06445 191026016972 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 191026016973 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 191026016974 GyrI-like small molecule binding domain; Region: GyrI-like; pfam06445 191026016975 The SYLF domain (also called DUF500), a novel lipid-binding module; Region: SYLF; cd11524 191026016976 putative amphipathic alpha helix; other site 191026016977 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 191026016978 Putative methyltransferase; Region: Methyltransf_20; pfam12147 191026016979 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 191026016980 transmembrane helices; other site 191026016981 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 191026016982 TrkA-C domain; Region: TrkA_C; pfam02080 191026016983 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 191026016984 DctM-like transporters; Region: DctM; pfam06808 191026016985 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 191026016986 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290 191026016987 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 191026016988 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 191026016989 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 191026016990 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 191026016991 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 191026016992 High-affinity nickel-transport protein; Region: NicO; cl00964 191026016993 TM1410 hypothetical-related protein; Region: DUF297; cl00997 191026016994 Curli production assembly/transport component CsgG; Region: CsgG; cl17434 191026016995 TM1410 hypothetical-related protein; Region: DUF297; pfam03537 191026016996 C-terminal Putative NodB-like catalytic domain of PelA-like uncharacterized hypothetical proteins found in bacteria; Region: CE4_PelA_like_C; cd10922 191026016997 putative active site [active] 191026016998 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 191026016999 TPR motif; other site 191026017000 binding surface 191026017001 Tetratricopeptide repeat; Region: TPR_16; pfam13432 191026017002 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 191026017003 TPR motif; other site 191026017004 binding surface 191026017005 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 191026017006 TPR motif; other site 191026017007 binding surface 191026017008 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 191026017009 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 191026017010 GAF domain; Region: GAF_3; pfam13492 191026017011 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 191026017012 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 191026017013 metal binding site [ion binding]; metal-binding site 191026017014 active site 191026017015 I-site; other site 191026017016 HEAT repeats; Region: HEAT_2; pfam13646 191026017017 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 191026017018 TPR motif; other site 191026017019 binding surface 191026017020 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_3; cd03813 191026017021 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 191026017022 Predicted membrane protein [Function unknown]; Region: COG4267 191026017023 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 191026017024 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 191026017025 NAD(P) binding site [chemical binding]; other site 191026017026 active site 191026017027 HDOD domain; Region: HDOD; pfam08668 191026017028 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 191026017029 Zn2+ binding site [ion binding]; other site 191026017030 Mg2+ binding site [ion binding]; other site 191026017031 Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675 191026017032 HAMP domain; Region: HAMP; pfam00672 191026017033 dimerization interface [polypeptide binding]; other site 191026017034 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 191026017035 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 191026017036 dimer interface [polypeptide binding]; other site 191026017037 putative CheW interface [polypeptide binding]; other site 191026017038 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 191026017039 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 191026017040 active site residue [active] 191026017041 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 191026017042 active site residue [active] 191026017043 Superoxide reductase-like (SORL) domain; present in a family of mononuclear non-heme iron proteins that includes superoxide reductase and desulfoferrodoxin. Superoxide reductase-like proteins scavenge superoxide anion radicals as a defense mechanism...; Region: SORL; cl00014 191026017044 non-heme iron binding site [ion binding]; other site 191026017045 Cache domain; Region: Cache_1; pfam02743 191026017046 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 191026017047 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 191026017048 dimer interface [polypeptide binding]; other site 191026017049 phosphorylation site [posttranslational modification] 191026017050 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 191026017051 ATP binding site [chemical binding]; other site 191026017052 Mg2+ binding site [ion binding]; other site 191026017053 G-X-G motif; other site 191026017054 Response regulator receiver domain; Region: Response_reg; pfam00072 191026017055 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 191026017056 active site 191026017057 phosphorylation site [posttranslational modification] 191026017058 intermolecular recognition site; other site 191026017059 dimerization interface [polypeptide binding]; other site 191026017060 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 191026017061 Ligand Binding Site [chemical binding]; other site 191026017062 Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075 191026017063 Protein of unknown function (DUF3365); Region: DUF3365; pfam11845 191026017064 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 191026017065 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 191026017066 dimer interface [polypeptide binding]; other site 191026017067 phosphorylation site [posttranslational modification] 191026017068 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 191026017069 ATP binding site [chemical binding]; other site 191026017070 Mg2+ binding site [ion binding]; other site 191026017071 G-X-G motif; other site 191026017072 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 191026017073 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 191026017074 active site 191026017075 phosphorylation site [posttranslational modification] 191026017076 intermolecular recognition site; other site 191026017077 dimerization interface [polypeptide binding]; other site 191026017078 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 191026017079 Walker A motif; other site 191026017080 ATP binding site [chemical binding]; other site 191026017081 Walker B motif; other site 191026017082 arginine finger; other site 191026017083 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 191026017084 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 191026017085 Predicted protein-tyrosine phosphatase [Signal transduction mechanisms]; Region: CDC14; COG2453 191026017086 active site 191026017087 catalytic residues [active] 191026017088 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 191026017089 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 191026017090 active site 191026017091 CoA binding site [chemical binding]; other site 191026017092 AMP binding site [chemical binding]; other site 191026017093 Uncharacterized BCR, YaiI/YqxD family COG1671; Region: DUF188; pfam02639 191026017094 Formylmethanofuran dehydrogenase subunit E [Energy production and conversion]; Region: COG2191 191026017095 FmdE, Molybdenum formylmethanofuran dehydrogenase operon; Region: FmdE; pfam02663 191026017096 MoeA_like. This domain is similar to a domain found in a variety of proteins involved in biosynthesis of molybdopterin cofactor, like MoaB, MogA, and MoeA. There this domain is presumed to bind molybdopterin. The exact function of this subgroup is...; Region: MoeA_like; cd03522 191026017097 putative MPT binding site; other site 191026017098 N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; cl17549 191026017099 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 191026017100 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 191026017101 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 191026017102 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 191026017103 molybdopterin cofactor binding site; other site 191026017104 4Fe-4S dicluster domain; Region: Fer4_11; pfam13247 191026017105 Protein involved in formate dehydrogenase formation; Region: FdhE; pfam04216 191026017106 formate dehydrogenase accessory protein FdhE; Region: FdhE; TIGR01562 191026017107 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 191026017108 active site 191026017109 thiamine phosphate binding site [chemical binding]; other site 191026017110 pyrophosphate binding site [ion binding]; other site 191026017111 thiamine biosynthesis protein ThiF; Provisional; Region: PRK08644 191026017112 Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cl17196 191026017113 ATP binding site [chemical binding]; other site 191026017114 substrate interface [chemical binding]; other site 191026017115 thiamine biosynthesis protein ThiH; Reviewed; Region: thiH; PRK09240 191026017116 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 191026017117 FeS/SAM binding site; other site 191026017118 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 191026017119 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 191026017120 ThiS interaction site; other site 191026017121 putative active site [active] 191026017122 tetramer interface [polypeptide binding]; other site 191026017123 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 191026017124 thiS-thiF/thiG interaction site; other site 191026017125 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 191026017126 PhoU domain; Region: PhoU; pfam01895 191026017127 PhoU domain; Region: PhoU; pfam01895 191026017128 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 191026017129 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 191026017130 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 191026017131 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 191026017132 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 191026017133 type I secretion system ATPase, LssB family; Region: type_I_sec_LssB; TIGR03375 191026017134 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 191026017135 ATP-binding cassette domain of bacteriocin exporters, subfamily C; Region: ABCC_bacteriocin_exporters; cd03245 191026017136 Walker A/P-loop; other site 191026017137 ATP binding site [chemical binding]; other site 191026017138 Q-loop/lid; other site 191026017139 ABC transporter signature motif; other site 191026017140 Walker B; other site 191026017141 D-loop; other site 191026017142 H-loop/switch region; other site 191026017143 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 191026017144 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 191026017145 HlyD family secretion protein; Region: HlyD_3; pfam13437 191026017146 PAS fold; Region: PAS_4; pfam08448 191026017147 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 191026017148 Zn2+ binding site [ion binding]; other site 191026017149 Mg2+ binding site [ion binding]; other site 191026017150 L-lactate permease; Region: Lactate_perm; cl00701 191026017151 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 191026017152 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 191026017153 type VI secretion-associated protein, VC_A0119 family; Region: VI_chp_7; TIGR03362 191026017154 Protein of unknown function (DUF770); Region: DUF770; pfam05591 191026017155 type VI secretion protein, EvpB/VC_A0108 family; Region: VI_chp_2; TIGR03355 191026017156 Protein of unknown function (DUF877); Region: DUF877; pfam05943 191026017157 type VI secretion system effector, Hcp1 family; Region: VI_effect_Hcp1; TIGR03344 191026017158 type VI secretion system lysozyme-like protein; Region: VI_zyme; TIGR03357 191026017159 Bacterial protein of unknown function (DUF879); Region: DUF879; pfam05947 191026017160 Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3519 191026017161 Protein of unknown function (DUF1305); Region: DUF1305; pfam06996 191026017162 type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345 191026017163 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 191026017164 Walker A motif; other site 191026017165 ATP binding site [chemical binding]; other site 191026017166 Walker B motif; other site 191026017167 arginine finger; other site 191026017168 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 191026017169 Walker A motif; other site 191026017170 ATP binding site [chemical binding]; other site 191026017171 Walker B motif; other site 191026017172 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 191026017173 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 191026017174 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 191026017175 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 191026017176 Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507 191026017177 trimer interface [polypeptide binding]; other site 191026017178 Uncharacterized protein conserved in bacteria (DUF2169); Region: DUF2169; pfam09937 191026017179 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 191026017180 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 191026017181 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 191026017182 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 191026017183 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 191026017184 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 191026017185 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 191026017186 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 191026017187 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 191026017188 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 191026017189 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 191026017190 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 191026017191 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 191026017192 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 191026017193 Protein of unknown function (DUF3540); Region: DUF3540; pfam12059 191026017194 Domain of unknown function (DUF4150); Region: DUF4150; pfam13665 191026017195 Protein of unknown function (DUF770); Region: DUF770; cl01402 191026017196 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3517; cl05484 191026017197 Type VI secretion lipoprotein; Region: T6SS-SciN; pfam12790 191026017198 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3522; cl01406 191026017199 Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936 191026017200 Uncharacterized protein conserved in bacteria (DUF2077); Region: DUF2077; pfam09850 191026017201 ImcF-related N-terminal domain; Region: ImcF-related_N; pfam14331 191026017202 Protein of unknown function (DUF1215); Region: DUF1215; pfam06744 191026017203 AMIN domain; Region: AMIN; pfam11741 191026017204 Cache domain; Region: Cache_1; pfam02743 191026017205 HAMP domain; Region: HAMP; pfam00672 191026017206 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 191026017207 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 191026017208 dimer interface [polypeptide binding]; other site 191026017209 putative CheW interface [polypeptide binding]; other site 191026017210 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 191026017211 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 191026017212 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 191026017213 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 191026017214 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 191026017215 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 191026017216 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 191026017217 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 191026017218 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 191026017219 nucleotide binding site [chemical binding]; other site 191026017220 NEF interaction site [polypeptide binding]; other site 191026017221 SBD interface [polypeptide binding]; other site 191026017222 GrpE; Region: GrpE; pfam01025 191026017223 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 191026017224 dimer interface [polypeptide binding]; other site 191026017225 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 191026017226 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 191026017227 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 191026017228 Fe2+ transport system protein A [Inorganic ion transport and metabolism]; Region: FeoA; COG1918 191026017229 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 191026017230 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 191026017231 G1 box; other site 191026017232 GTP/Mg2+ binding site [chemical binding]; other site 191026017233 Switch I region; other site 191026017234 G2 box; other site 191026017235 G3 box; other site 191026017236 Switch II region; other site 191026017237 G4 box; other site 191026017238 G5 box; other site 191026017239 Nucleoside recognition; Region: Gate; pfam07670 191026017240 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 191026017241 Nucleoside recognition; Region: Gate; pfam07670 191026017242 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 191026017243 Clp amino terminal domain; Region: Clp_N; pfam02861 191026017244 Clp amino terminal domain; Region: Clp_N; pfam02861 191026017245 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 191026017246 Walker A motif; other site 191026017247 ATP binding site [chemical binding]; other site 191026017248 Walker B motif; other site 191026017249 arginine finger; other site 191026017250 Calmodulin-binding; Region: Enkurin; pfam13864 191026017251 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 191026017252 Walker A motif; other site 191026017253 ATP binding site [chemical binding]; other site 191026017254 Walker B motif; other site 191026017255 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 191026017256 MerR HTH family regulatory protein; Region: MerR_2; pfam13591 191026017257 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 191026017258 DNA binding residues [nucleotide binding] 191026017259 curved DNA-binding protein CbpA; Provisional; Region: PRK10266 191026017260 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 191026017261 HSP70 interaction site [polypeptide binding]; other site 191026017262 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 191026017263 substrate binding site [polypeptide binding]; other site 191026017264 dimer interface [polypeptide binding]; other site 191026017265 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 191026017266 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 191026017267 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 191026017268 RNA binding surface [nucleotide binding]; other site 191026017269 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 191026017270 active site 191026017271 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 191026017272 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 191026017273 CoA-binding site [chemical binding]; other site 191026017274 ATP-binding [chemical binding]; other site 191026017275 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 191026017276 active site 191026017277 Xanthine/uracil permeases [Nucleotide transport and metabolism]; Region: UraA; COG2233 191026017278 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 191026017279 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 191026017280 Ligand Binding Site [chemical binding]; other site 191026017281 phosphatidylserine decarboxylase; Provisional; Region: PRK05305 191026017282 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 191026017283 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 191026017284 2-isopropylmalate synthase; Validated; Region: PRK00915 191026017285 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 191026017286 active site 191026017287 catalytic residues [active] 191026017288 metal binding site [ion binding]; metal-binding site 191026017289 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 191026017290 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 191026017291 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 191026017292 substrate binding site [chemical binding]; other site 191026017293 ligand binding site [chemical binding]; other site 191026017294 3-isopropylmalate dehydratase small subunit; Reviewed; Region: leuD; PRK00439 191026017295 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 191026017296 substrate binding site [chemical binding]; other site 191026017297 tartrate dehydrogenase; Region: TTC; TIGR02089 191026017298 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 191026017299 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 191026017300 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 191026017301 Cobalt chelatase (CbiK); Region: CbiK; pfam06180 191026017302 Anaerobic cobalamin biosynthetic cobalt chelatase (CbiK), N-terminal domain. CbiK is part of the cobalt-early path for cobalamin biosynthesis. It catalyzes the insertion of cobalt into the oxidized form of precorrin-2, factor II (sirohydrochlorin), the...; Region: CbiK_N; cd03412 191026017303 active site 191026017304 C-terminal domain interface [polypeptide binding]; other site 191026017305 Anaerobic cobalamin biosynthetic cobalt chelatase (CbiK), C-terminal domain. CbiK is part of the cobalt-early path for cobalamin biosynthesis. It catalyzes the insertion of cobalt into the oxidized form of precorrin-2, factor II (sirohydrochlorin), the...; Region: CbiK_C; cd03413 191026017306 active site 191026017307 N-terminal domain interface [polypeptide binding]; other site 191026017308 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 191026017309 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 191026017310 ABC-ATPase subunit interface; other site 191026017311 dimer interface [polypeptide binding]; other site 191026017312 putative PBP binding regions; other site 191026017313 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 191026017314 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 191026017315 Walker A/P-loop; other site 191026017316 ATP binding site [chemical binding]; other site 191026017317 Q-loop/lid; other site 191026017318 ABC transporter signature motif; other site 191026017319 Walker B; other site 191026017320 D-loop; other site 191026017321 H-loop/switch region; other site 191026017322 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 191026017323 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 191026017324 intersubunit interface [polypeptide binding]; other site 191026017325 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 191026017326 active site 191026017327 SAM binding site [chemical binding]; other site 191026017328 homodimer interface [polypeptide binding]; other site 191026017329 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 191026017330 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 191026017331 pyridoxal 5'-phosphate binding site [chemical binding]; other site 191026017332 catalytic residue [active] 191026017333 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 191026017334 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 191026017335 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 191026017336 FAD binding site [chemical binding]; other site 191026017337 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 191026017338 active site 191026017339 8-oxo-dGMP binding site [chemical binding]; other site 191026017340 nudix motif; other site 191026017341 metal binding site [ion binding]; metal-binding site 191026017342 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 191026017343 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 191026017344 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 191026017345 ABC transporter; Region: ABC_tran_2; pfam12848 191026017346 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 191026017347 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 191026017348 GIY-YIG motif/motif A; other site 191026017349 putative active site [active] 191026017350 putative metal binding site [ion binding]; other site 191026017351 Chloramphenicol O-acetyltransferase [Defense mechanisms]; Region: COG4845 191026017352 Chloramphenicol acetyltransferase; Region: CAT; cl02008 191026017353 DUF based on E. rectale Gene description (DUF3880); Region: DUF3880; pfam12996 191026017354 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 191026017355 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 191026017356 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 191026017357 active site 191026017358 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 191026017359 Uncharacterized protein related to glutamine synthetase [General function prediction only]; Region: COG3968 191026017360 Glutamine synthetase type III N terminal; Region: GSIII_N; pfam12437 191026017361 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 191026017362 glutamine ABC transporter periplasmic protein; Reviewed; Region: glnH; PRK09495 191026017363 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 191026017364 substrate binding pocket [chemical binding]; other site 191026017365 membrane-bound complex binding site; other site 191026017366 hinge residues; other site 191026017367 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 191026017368 dimer interface [polypeptide binding]; other site 191026017369 conserved gate region; other site 191026017370 putative PBP binding loops; other site 191026017371 ABC-ATPase subunit interface; other site 191026017372 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 191026017373 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 191026017374 Walker A/P-loop; other site 191026017375 ATP binding site [chemical binding]; other site 191026017376 Q-loop/lid; other site 191026017377 ABC transporter signature motif; other site 191026017378 Walker B; other site 191026017379 D-loop; other site 191026017380 H-loop/switch region; other site 191026017381 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cl17302 191026017382 Ca2+ binding site [ion binding]; other site 191026017383 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093 191026017384 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 191026017385 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344 191026017386 putative NAD(P) binding site [chemical binding]; other site 191026017387 putative active site [active] 191026017388 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; pfam01977 191026017389 Pleckstrin homology (PH)-like domains in bacteria (PHb); Region: PH-like_bacteria; cd13225 191026017390 pentamer interface [polypeptide binding]; other site 191026017391 dodecaamer interface [polypeptide binding]; other site 191026017392 conserved hypothetical protein; Region: TIGR02285 191026017393 Ferredoxin thioredoxin reductase catalytic beta chain; Region: FeThRed_B; cl01977 191026017394 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 191026017395 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535 191026017396 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 191026017397 FeS/SAM binding site; other site 191026017398 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 191026017399 Formyltransferase, catalytic core domain; Region: FMT_core; cl00395 191026017400 active site 191026017401 cosubstrate binding site; other site 191026017402 substrate binding site [chemical binding]; other site 191026017403 catalytic site [active] 191026017404 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 191026017405 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 191026017406 putative active site [active] 191026017407 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 191026017408 nucleoside/Zn binding site; other site 191026017409 dimer interface [polypeptide binding]; other site 191026017410 catalytic motif [active] 191026017411 CobB/CobQ-like glutamine amidotransferase domain; Region: GATase_5; pfam13507 191026017412 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 191026017413 conserved cys residue [active] 191026017414 CTP synthetase; Validated; Region: pyrG; PRK05380 191026017415 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 191026017416 Catalytic site [active] 191026017417 active site 191026017418 UTP binding site [chemical binding]; other site 191026017419 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 191026017420 active site 191026017421 putative oxyanion hole; other site 191026017422 catalytic triad [active] 191026017423 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198 191026017424 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 191026017425 HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662 191026017426 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 191026017427 active site 191026017428 motif I; other site 191026017429 motif II; other site 191026017430 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 191026017431 Bacterial SH3 domain; Region: SH3_3; pfam08239 191026017432 lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002 191026017433 OstA-like protein; Region: OstA; cl00844 191026017434 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 191026017435 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 191026017436 Walker A/P-loop; other site 191026017437 ATP binding site [chemical binding]; other site 191026017438 Q-loop/lid; other site 191026017439 ABC transporter signature motif; other site 191026017440 Walker B; other site 191026017441 D-loop; other site 191026017442 H-loop/switch region; other site 191026017443 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 191026017444 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 191026017445 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 191026017446 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 191026017447 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 191026017448 30S subunit binding site; other site 191026017449 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 191026017450 active site 191026017451 phosphorylation site [posttranslational modification] 191026017452 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 191026017453 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 191026017454 active pocket/dimerization site; other site 191026017455 active site 191026017456 phosphorylation site [posttranslational modification] 191026017457 PTS system sorbose subfamily IIB component; Region: PTSIIB_sorb; pfam03830 191026017458 active site 191026017459 phosphorylation site [posttranslational modification] 191026017460 PTS system sorbose-specific iic component; Region: EII-Sor; cl01506 191026017461 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427 191026017462 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 191026017463 DHHA2 domain; Region: DHHA2; pfam02833 191026017464 ThiS family; Region: ThiS; pfam02597 191026017465 charged pocket; other site 191026017466 hydrophobic patch; other site 191026017467 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 191026017468 tetramerization interface [polypeptide binding]; other site 191026017469 active site 191026017470 PEGA domain; Region: PEGA; pfam08308 191026017471 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 191026017472 Zn2+ binding site [ion binding]; other site 191026017473 Mg2+ binding site [ion binding]; other site 191026017474 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 191026017475 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 191026017476 Walker A/P-loop; other site 191026017477 ATP binding site [chemical binding]; other site 191026017478 Q-loop/lid; other site 191026017479 ABC transporter signature motif; other site 191026017480 Walker B; other site 191026017481 D-loop; other site 191026017482 H-loop/switch region; other site 191026017483 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 191026017484 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 191026017485 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 191026017486 Walker A/P-loop; other site 191026017487 ATP binding site [chemical binding]; other site 191026017488 Q-loop/lid; other site 191026017489 ABC transporter signature motif; other site 191026017490 Walker B; other site 191026017491 D-loop; other site 191026017492 H-loop/switch region; other site 191026017493 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 191026017494 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 191026017495 Glucose inhibited division protein A; Region: GIDA; pfam01134 191026017496 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 191026017497 dihydrodipicolinate synthase; Region: dapA; TIGR00674 191026017498 dimer interface [polypeptide binding]; other site 191026017499 active site 191026017500 catalytic residue [active] 191026017501 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 191026017502 IHF - DNA interface [nucleotide binding]; other site 191026017503 IHF dimer interface [polypeptide binding]; other site 191026017504 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 191026017505 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 191026017506 FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038 191026017507 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 191026017508 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 191026017509 metal binding site [ion binding]; metal-binding site 191026017510 active site 191026017511 I-site; other site 191026017512 This domain is found in peptide chain release factors; Region: PCRF; smart00937 191026017513 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 191026017514 RF-1 domain; Region: RF-1; pfam00472 191026017515 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 191026017516 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 191026017517 putative active site [active] 191026017518 catalytic triad [active] 191026017519 putative dimer interface [polypeptide binding]; other site 191026017520 FOG: CBS domain [General function prediction only]; Region: COG0517 191026017521 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 191026017522 Transporter associated domain; Region: CorC_HlyC; smart01091 191026017523 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 191026017524 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 191026017525 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 191026017526 diaminopimelate aminotransferase; Provisional; Region: PRK13983 191026017527 M20 Peptidases with similarity to acetylornithine deacetylases and succinyl-diaminopimelate desuccinylases; Region: M20_ArgE_DapE_like1; cd05650 191026017528 metal binding site [ion binding]; metal-binding site 191026017529 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 191026017530 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 191026017531 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 191026017532 active site 191026017533 seryl-tRNA synthetase; Provisional; Region: PRK05431 191026017534 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 191026017535 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 191026017536 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 191026017537 S-adenosylmethionine binding site [chemical binding]; other site 191026017538 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 191026017539 IHF dimer interface [polypeptide binding]; other site 191026017540 IHF - DNA interface [nucleotide binding]; other site 191026017541 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 191026017542 Yqey-like protein; Region: YqeY; pfam09424 191026017543 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 191026017544 MutS domain III; Region: MutS_III; pfam05192 191026017545 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 191026017546 Walker A/P-loop; other site 191026017547 ATP binding site [chemical binding]; other site 191026017548 Q-loop/lid; other site 191026017549 ABC transporter signature motif; other site 191026017550 Walker B; other site 191026017551 D-loop; other site 191026017552 H-loop/switch region; other site 191026017553 Smr domain; Region: Smr; pfam01713 191026017554 DNA primase, catalytic core; Region: dnaG; TIGR01391 191026017555 CHC2 zinc finger; Region: zf-CHC2; pfam01807 191026017556 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 191026017557 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 191026017558 active site 191026017559 metal binding site [ion binding]; metal-binding site 191026017560 interdomain interaction site; other site 191026017561 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 191026017562 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 191026017563 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 191026017564 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 191026017565 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 191026017566 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 191026017567 DNA binding residues [nucleotide binding] 191026017568 CobD/Cbib protein; Region: CobD_Cbib; pfam03186 191026017569 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 191026017570 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 191026017571 pyrroline-5-carboxylate reductase; Region: PLN02688 191026017572 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 191026017573 active site 191026017574 multimer interface [polypeptide binding]; other site 191026017575 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101 191026017576 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 191026017577 Walker A/P-loop; other site 191026017578 ATP binding site [chemical binding]; other site 191026017579 Q-loop/lid; other site 191026017580 ABC transporter signature motif; other site 191026017581 Walker B; other site 191026017582 D-loop; other site 191026017583 H-loop/switch region; other site 191026017584 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 191026017585 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574 191026017586 TM-ABC transporter signature motif; other site 191026017587 Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325 191026017588 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 191026017589 zinc binding site [ion binding]; other site 191026017590 putative ligand binding site [chemical binding]; other site 191026017591 Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936 191026017592 NodB motif; other site 191026017593 putative active site [active] 191026017594 putative catalytic site [active] 191026017595 Zn binding site [ion binding]; other site 191026017596 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 191026017597 C-terminal peptidase (prc); Region: prc; TIGR00225 191026017598 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 191026017599 protein binding site [polypeptide binding]; other site 191026017600 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 191026017601 Catalytic dyad [active] 191026017602 Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942 191026017603 Peptidase family M23; Region: Peptidase_M23; pfam01551 191026017604 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 191026017605 endonuclease III; Region: ENDO3c; smart00478 191026017606 minor groove reading motif; other site 191026017607 helix-hairpin-helix signature motif; other site 191026017608 substrate binding pocket [chemical binding]; other site 191026017609 active site 191026017610 ribosomal protein L11 methyltransferase; Reviewed; Region: prmA; PRK00517 191026017611 S-adenosylmethionine binding site [chemical binding]; other site 191026017612 Methyltransferase domain; Region: Methyltransf_18; pfam12847 191026017613 acetylornithine aminotransferase; Provisional; Region: PRK02627 191026017614 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 191026017615 inhibitor-cofactor binding pocket; inhibition site 191026017616 pyridoxal 5'-phosphate binding site [chemical binding]; other site 191026017617 catalytic residue [active] 191026017618 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 191026017619 trimer interface [polypeptide binding]; other site 191026017620 active site 191026017621 This family is most closely related to the oligosaccharide phosphorylase domain family and other unidentified sequences. Oligosaccharide phosphorylase catalyzes the breakdown of oligosaccharides into glucose-1-phosphate units. They are important...; Region: GT1_Glycogen_Phosphorylase_like; cd04299 191026017622 putative homodimer interface [polypeptide binding]; other site 191026017623 putative active site pocket [active] 191026017624 alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094 191026017625 Staphylococcal nuclease homologues; Region: SNc; smart00318 191026017626 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175 191026017627 Catalytic site; other site 191026017628 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 191026017629 4Fe-4S binding domain; Region: Fer4; pfam00037 191026017630 Conserved region in glutamate synthase; Region: Glu_synthase; pfam01645 191026017631 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 191026017632 active site 191026017633 FMN binding site [chemical binding]; other site 191026017634 substrate binding site [chemical binding]; other site 191026017635 3Fe-4S cluster binding site [ion binding]; other site 191026017636 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 191026017637 4Fe-4S binding domain; Region: Fer4; cl02805 191026017638 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 191026017639 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 191026017640 Glutamate synthase domain 1 [Amino acid transport and metabolism]; Region: GltB; COG0067 191026017641 Glutamine amidotransferases class-II (Gn-AT)_GlxB-type. GlxB is a glutamine amidotransferase-like protein of unknown function found in bacteria and archaea. GlxB has a structural fold similar to that of other class II glutamine amidotransferases...; Region: GlxB; cd01907 191026017642 putative active site [active] 191026017643 Archaeal-type gltB domain. This domain shares sequence similarity with a region of unknown function found in the large subunit of glutamate synthase, which is encoded by gltB and found in most bacteria and eukaryotes. It is predicted to be homologous to...; Region: arch_gltB; cd00981 191026017644 putative subunit interface; other site 191026017645 Preprotein translocase subunit; Region: YajC; pfam02699 191026017646 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 191026017647 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 191026017648 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 191026017649 Protein export membrane protein; Region: SecD_SecF; pfam02355 191026017650 Aldehyde ferredoxin oxidoreductase, N-terminal domain; Region: AFOR_N; smart00790 191026017651 Aldehyde:ferredoxin oxidoreductase [Energy production and conversion]; Region: COG2414 191026017652 Aldehyde ferredoxin oxidoreductase, domains 2 & 3; Region: AFOR_C; pfam01314 191026017653 4Fe-4S binding domain; Region: Fer4_5; pfam12801 191026017654 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 191026017655 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 191026017656 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 191026017657 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 191026017658 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 191026017659 NADP binding site [chemical binding]; other site 191026017660 active site 191026017661 putative substrate binding site [chemical binding]; other site 191026017662 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 191026017663 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 191026017664 NAD binding site [chemical binding]; other site 191026017665 substrate binding site [chemical binding]; other site 191026017666 homodimer interface [polypeptide binding]; other site 191026017667 active site 191026017668 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 191026017669 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 191026017670 homotrimer interaction site [polypeptide binding]; other site 191026017671 putative active site [active] 191026017672 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 191026017673 anti sigma factor interaction site; other site 191026017674 regulatory phosphorylation site [posttranslational modification]; other site 191026017675 Response regulator receiver domain; Region: Response_reg; pfam00072 191026017676 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 191026017677 active site 191026017678 phosphorylation site [posttranslational modification] 191026017679 intermolecular recognition site; other site 191026017680 dimerization interface [polypeptide binding]; other site 191026017681 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 191026017682 Histidine kinase; Region: HisKA_2; pfam07568 191026017683 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 191026017684 ATP binding site [chemical binding]; other site 191026017685 Mg2+ binding site [ion binding]; other site 191026017686 G-X-G motif; other site 191026017687 PilZ domain; Region: PilZ; pfam07238 191026017688 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 191026017689 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 191026017690 Walker A/P-loop; other site 191026017691 ATP binding site [chemical binding]; other site 191026017692 Q-loop/lid; other site 191026017693 ABC transporter signature motif; other site 191026017694 Walker B; other site 191026017695 D-loop; other site 191026017696 H-loop/switch region; other site 191026017697 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 191026017698 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 191026017699 dimer interface [polypeptide binding]; other site 191026017700 conserved gate region; other site 191026017701 putative PBP binding loops; other site 191026017702 ABC-ATPase subunit interface; other site 191026017703 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 191026017704 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 191026017705 substrate binding pocket [chemical binding]; other site 191026017706 membrane-bound complex binding site; other site 191026017707 hinge residues; other site 191026017708 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 191026017709 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 191026017710 substrate binding pocket [chemical binding]; other site 191026017711 membrane-bound complex binding site; other site 191026017712 hinge residues; other site 191026017713 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 191026017714 dimer interface [polypeptide binding]; other site 191026017715 conserved gate region; other site 191026017716 putative PBP binding loops; other site 191026017717 ABC-ATPase subunit interface; other site 191026017718 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 191026017719 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 191026017720 Walker A/P-loop; other site 191026017721 ATP binding site [chemical binding]; other site 191026017722 Q-loop/lid; other site 191026017723 ABC transporter signature motif; other site 191026017724 Walker B; other site 191026017725 D-loop; other site 191026017726 H-loop/switch region; other site 191026017727 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 191026017728 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 191026017729 active site 191026017730 phosphorylation site [posttranslational modification] 191026017731 intermolecular recognition site; other site 191026017732 dimerization interface [polypeptide binding]; other site 191026017733 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 191026017734 dimer interface [polypeptide binding]; other site 191026017735 phosphorylation site [posttranslational modification] 191026017736 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 191026017737 ATP binding site [chemical binding]; other site 191026017738 Mg2+ binding site [ion binding]; other site 191026017739 G-X-G motif; other site 191026017740 Response regulator receiver domain; Region: Response_reg; pfam00072 191026017741 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 191026017742 active site 191026017743 phosphorylation site [posttranslational modification] 191026017744 intermolecular recognition site; other site 191026017745 dimerization interface [polypeptide binding]; other site 191026017746 Domain of unknown function DUF20; Region: UPF0118; pfam01594 191026017747 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 191026017748 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 191026017749 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 191026017750 active site 191026017751 metal binding site [ion binding]; metal-binding site 191026017752 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 191026017753 Membrane-bound lytic murein transglycosylase [Cell envelope biogenesis, outer membrane]; Region: MltA; COG2821 191026017754 MltA specific insert domain; Region: MltA; smart00925 191026017755 3D domain; Region: 3D; pfam06725 191026017756 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 191026017757 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 191026017758 active site 191026017759 Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294 191026017760 active site 191026017761 substrate binding pocket [chemical binding]; other site 191026017762 dimer interface [polypeptide binding]; other site 191026017763 allantoate amidohydrolase; Reviewed; Region: PRK09290 191026017764 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 191026017765 active site 191026017766 metal binding site [ion binding]; metal-binding site 191026017767 dimer interface [polypeptide binding]; other site 191026017768 DctM-like transporters; Region: DctM; pfam06808 191026017769 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 191026017770 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290 191026017771 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 191026017772 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 191026017773 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 191026017774 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 191026017775 non-specific DNA binding site [nucleotide binding]; other site 191026017776 salt bridge; other site 191026017777 sequence-specific DNA binding site [nucleotide binding]; other site 191026017778 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 191026017779 Peptidase family U32; Region: Peptidase_U32; pfam01136 191026017780 Peptidase family U32; Region: Peptidase_U32; cl03113 191026017781 dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054 191026017782 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218 191026017783 FAD binding pocket [chemical binding]; other site 191026017784 FAD binding motif [chemical binding]; other site 191026017785 phosphate binding motif [ion binding]; other site 191026017786 beta-alpha-beta structure motif; other site 191026017787 NAD binding pocket [chemical binding]; other site 191026017788 Iron coordination center [ion binding]; other site 191026017789 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 191026017790 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 191026017791 heterodimer interface [polypeptide binding]; other site 191026017792 active site 191026017793 FMN binding site [chemical binding]; other site 191026017794 homodimer interface [polypeptide binding]; other site 191026017795 substrate binding site [chemical binding]; other site 191026017796 DEAD-like helicases superfamily; Region: DEXDc; smart00487 191026017797 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 191026017798 ATP binding site [chemical binding]; other site 191026017799 putative Mg++ binding site [ion binding]; other site 191026017800 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 191026017801 nucleotide binding region [chemical binding]; other site 191026017802 ATP-binding site [chemical binding]; other site 191026017803 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 191026017804 dimerization interface [polypeptide binding]; other site 191026017805 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 191026017806 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 191026017807 dimer interface [polypeptide binding]; other site 191026017808 putative CheW interface [polypeptide binding]; other site 191026017809 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 191026017810 TPR motif; other site 191026017811 TPR repeat; Region: TPR_11; pfam13414 191026017812 binding surface 191026017813 trigger factor; Region: tig; TIGR00115 191026017814 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 191026017815 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 191026017816 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 191026017817 oligomer interface [polypeptide binding]; other site 191026017818 active site residues [active] 191026017819 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 191026017820 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 191026017821 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 191026017822 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 191026017823 Walker A motif; other site 191026017824 ATP binding site [chemical binding]; other site 191026017825 Walker B motif; other site 191026017826 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 191026017827 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 191026017828 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 191026017829 PAS fold; Region: PAS_3; pfam08447 191026017830 putative active site [active] 191026017831 heme pocket [chemical binding]; other site 191026017832 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 191026017833 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 191026017834 putative active site [active] 191026017835 heme pocket [chemical binding]; other site 191026017836 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 191026017837 dimer interface [polypeptide binding]; other site 191026017838 phosphorylation site [posttranslational modification] 191026017839 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 191026017840 ATP binding site [chemical binding]; other site 191026017841 Mg2+ binding site [ion binding]; other site 191026017842 G-X-G motif; other site 191026017843 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 191026017844 Found in ATP-dependent protease La (LON); Region: LON; smart00464 191026017845 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 191026017846 Walker A motif; other site 191026017847 ATP binding site [chemical binding]; other site 191026017848 Walker B motif; other site 191026017849 arginine finger; other site 191026017850 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 191026017851 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 191026017852 Beta-lactamase; Region: Beta-lactamase; pfam00144 191026017853 Alkaline phosphatase [Inorganic ion transport and metabolism]; Region: PhoA; COG1785 191026017854 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cl15837 191026017855 dimer interface [polypeptide binding]; other site 191026017856 active site 191026017857 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cl15837 191026017858 YibE/F-like protein; Region: YibE_F; pfam07907 191026017859 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 191026017860 Peptidase family M23; Region: Peptidase_M23; pfam01551 191026017861 Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409 191026017862 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 191026017863 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 191026017864 Nickel-dependent hydrogenase; Region: NiFeSe_Hases; pfam00374 191026017865 Hydrogenase specific C-terminal endopeptidases, also called Hydrogen Maturation Proteases (H2MP). These enzymes belong to the peptidase family M52. Maturation of [FeNi] hydrogenases includes formation of the nickel metallocenter, proteolytic processing...; Region: H2MP; cl00477 191026017866 nickel binding site [ion binding]; other site 191026017867 FOG: CBS domain [General function prediction only]; Region: COG0517 191026017868 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 191026017869 Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518 191026017870 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 191026017871 S-adenosylmethionine binding site [chemical binding]; other site 191026017872 Domain of unknown function (DUF368); Region: DUF368; pfam04018 191026017873 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 191026017874 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 191026017875 Walker A motif; other site 191026017876 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 191026017877 Septum formation initiator; Region: DivIC; pfam04977 191026017878 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 191026017879 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 191026017880 TPR motif; other site 191026017881 binding surface 191026017882 Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354 191026017883 AMP binding site [chemical binding]; other site 191026017884 metal binding site [ion binding]; metal-binding site 191026017885 active site 191026017886 UGMP family protein; Validated; Region: PRK09604 191026017887 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 191026017888 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 191026017889 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 191026017890 catalytic residues [active] 191026017891 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 191026017892 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 191026017893 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 191026017894 outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302 191026017895 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cl10029 191026017896 elongation factor G; Reviewed; Region: PRK12740 191026017897 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 191026017898 G1 box; other site 191026017899 putative GEF interaction site [polypeptide binding]; other site 191026017900 GTP/Mg2+ binding site [chemical binding]; other site 191026017901 Switch I region; other site 191026017902 G2 box; other site 191026017903 G3 box; other site 191026017904 Switch II region; other site 191026017905 G4 box; other site 191026017906 G5 box; other site 191026017907 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 191026017908 Elongation Factor G-like domain IV. This family includes the translational elongation factor termed EF-2 (for Archaea and Eukarya) and EF-G (for Bacteria), ribosomal protection proteins that mediate tetracycline resistance and, an evolutionarily...; Region: EFG_like_IV; cd01680 191026017909 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 191026017910 Uncharacterized protein conserved in bacteria (DUF2062); Region: DUF2062; pfam09835 191026017911 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 191026017912 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 191026017913 putative binding surface; other site 191026017914 active site 191026017915 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 191026017916 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 191026017917 ATP binding site [chemical binding]; other site 191026017918 Mg2+ binding site [ion binding]; other site 191026017919 G-X-G motif; other site 191026017920 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 191026017921 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 191026017922 Methyltransferase, chemotaxis proteins; Region: MeTrc; smart00138 191026017923 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 191026017924 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 191026017925 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 191026017926 active site 191026017927 phosphorylation site [posttranslational modification] 191026017928 intermolecular recognition site; other site 191026017929 dimerization interface [polypeptide binding]; other site 191026017930 CheB methylesterase; Region: CheB_methylest; pfam01339 191026017931 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 191026017932 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 191026017933 putative active site [active] 191026017934 putative metal binding site [ion binding]; other site 191026017935 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 191026017936 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 191026017937 putative active site [active] 191026017938 heme pocket [chemical binding]; other site 191026017939 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 191026017940 ATP binding site [chemical binding]; other site 191026017941 Mg2+ binding site [ion binding]; other site 191026017942 G-X-G motif; other site 191026017943 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 191026017944 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 191026017945 active site 191026017946 phosphorylation site [posttranslational modification] 191026017947 intermolecular recognition site; other site 191026017948 dimerization interface [polypeptide binding]; other site 191026017949 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 191026017950 Walker A motif; other site 191026017951 ATP binding site [chemical binding]; other site 191026017952 Walker B motif; other site 191026017953 arginine finger; other site 191026017954 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 191026017955 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 191026017956 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 191026017957 acyl-activating enzyme (AAE) consensus motif; other site 191026017958 active site 191026017959 AMP binding site [chemical binding]; other site 191026017960 CoA binding site [chemical binding]; other site 191026017961 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 191026017962 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 191026017963 Walker A/P-loop; other site 191026017964 ATP binding site [chemical binding]; other site 191026017965 Q-loop/lid; other site 191026017966 ABC transporter signature motif; other site 191026017967 Walker B; other site 191026017968 D-loop; other site 191026017969 H-loop/switch region; other site 191026017970 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 191026017971 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_1; cd06334 191026017972 putative ligand binding site [chemical binding]; other site 191026017973 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 191026017974 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 191026017975 TM-ABC transporter signature motif; other site 191026017976 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 191026017977 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 191026017978 TM-ABC transporter signature motif; other site 191026017979 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 191026017980 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 191026017981 acyl-activating enzyme (AAE) consensus motif; other site 191026017982 putative AMP binding site [chemical binding]; other site 191026017983 putative active site [active] 191026017984 putative CoA binding site [chemical binding]; other site 191026017985 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 191026017986 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 191026017987 Walker A/P-loop; other site 191026017988 ATP binding site [chemical binding]; other site 191026017989 Q-loop/lid; other site 191026017990 ABC transporter signature motif; other site 191026017991 Walker B; other site 191026017992 D-loop; other site 191026017993 H-loop/switch region; other site 191026017994 FOG: CBS domain [General function prediction only]; Region: COG0517 191026017995 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 191026017996 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 191026017997 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 191026017998 classical (c) SDRs; Region: SDR_c; cd05233 191026017999 NAD(P) binding site [chemical binding]; other site 191026018000 active site 191026018001 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 191026018002 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 191026018003 Histidine kinase; Region: HisKA_3; pfam07730 191026018004 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 191026018005 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 191026018006 ATP binding site [chemical binding]; other site 191026018007 Mg2+ binding site [ion binding]; other site 191026018008 G-X-G motif; other site 191026018009 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 191026018010 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 191026018011 active site 191026018012 phosphorylation site [posttranslational modification] 191026018013 intermolecular recognition site; other site 191026018014 dimerization interface [polypeptide binding]; other site 191026018015 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 191026018016 DNA binding residues [nucleotide binding] 191026018017 dimerization interface [polypeptide binding]; other site 191026018018 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 191026018019 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 191026018020 4Fe-4S binding domain; Region: Fer4; pfam00037 191026018021 Nitroreductase family. Members of this family utilize FMN as a cofactor. This family is involved in the reduction of flavin or nitroaromatic compounds by using NAD(P)H as electron donor in a obligatory two-electron transfer. Nitrogenase is homodimer; Region: NADH_nitroreductase; cd02143 191026018022 putative FMN binding site [chemical binding]; other site 191026018023 Transcriptional regulator PadR-like family; Region: PadR; cl17335 191026018024 Predicted transcriptional regulators [Transcription]; Region: COG1695 191026018025 methanogenesis imperfect marker protein 11; Region: methan_mark_11; TIGR03280 191026018026 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 191026018027 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 191026018028 substrate binding pocket [chemical binding]; other site 191026018029 membrane-bound complex binding site; other site 191026018030 hinge residues; other site 191026018031 TRAP-type mannitol/chloroaromatic compound transport system, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT1; COG4663 191026018032 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 191026018033 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; cl01181 191026018034 TRAP-type mannitol/chloroaromatic compound transport system, large permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT3; COG4664 191026018035 DctM-like transporters; Region: DctM; pfam06808 191026018036 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 191026018037 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 191026018038 GAF domain; Region: GAF; cl17456 191026018039 Histidine kinase; Region: His_kinase; pfam06580 191026018040 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 191026018041 ATP binding site [chemical binding]; other site 191026018042 Mg2+ binding site [ion binding]; other site 191026018043 G-X-G motif; other site 191026018044 putative two-component response-regulatory protein YehT; Provisional; Region: PRK11697 191026018045 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 191026018046 active site 191026018047 phosphorylation site [posttranslational modification] 191026018048 intermolecular recognition site; other site 191026018049 dimerization interface [polypeptide binding]; other site 191026018050 LytTr DNA-binding domain; Region: LytTR; smart00850 191026018051 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 191026018052 Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093 191026018053 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 191026018054 non-specific DNA binding site [nucleotide binding]; other site 191026018055 salt bridge; other site 191026018056 sequence-specific DNA binding site [nucleotide binding]; other site 191026018057 Plasmid maintenance system killer protein; Region: Plasmid_killer; cl01422 191026018058 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 191026018059 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 191026018060 Walker A/P-loop; other site 191026018061 ATP binding site [chemical binding]; other site 191026018062 Q-loop/lid; other site 191026018063 ABC transporter signature motif; other site 191026018064 Walker B; other site 191026018065 D-loop; other site 191026018066 H-loop/switch region; other site 191026018067 TOBE domain; Region: TOBE_2; pfam08402 191026018068 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 191026018069 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 191026018070 dimer interface [polypeptide binding]; other site 191026018071 conserved gate region; other site 191026018072 putative PBP binding loops; other site 191026018073 ABC-ATPase subunit interface; other site 191026018074 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 191026018075 dimer interface [polypeptide binding]; other site 191026018076 conserved gate region; other site 191026018077 putative PBP binding loops; other site 191026018078 ABC-ATPase subunit interface; other site 191026018079 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 191026018080 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 191026018081 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 191026018082 sodium--glutamate symport carrier (gltS); Region: gltS; TIGR00210 191026018083 Domain of unknown function (DUF4172); Region: DUF4172; pfam13776 191026018084 Domain of unknown function (DUF4172); Region: DUF4172; pfam13776 191026018085 CRISPR/Cas system-associated RAMP superfamily protein Cas6f; Region: Cas6_I-F; cd09739 191026018086 CRISPR/Cas system-associated RAMP superfamily protein Csy3; Region: Csy3_I-F; cd09737 191026018087 CRISPR/Cas system-associated RAMP superfamily protein Csy2; Region: Csy2_I-F; cd09736 191026018088 CRISPR/Cas system-associated protein Csy1; Region: Csy1_I-F; cl09829 191026018089 CRISPR/Cas system-associated protein Cas3/Cas2; Region: Cas3_Cas2_I-F; cd09673 191026018090 CRISPR-associated helicase Cas3, subtype I-F/YPEST; Region: cas3_yersinia; TIGR02562 191026018091 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cl00656 191026018092 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 191026018093 Major Facilitator Superfamily; Region: MFS_1; pfam07690 191026018094 putative substrate translocation pore; other site 191026018095 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 191026018096 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 191026018097 Hemerythrin; Region: Hemerythrin; cd12107 191026018098 Fe binding site [ion binding]; other site 191026018099 FtsH Extracellular; Region: FtsH_ext; pfam06480 191026018100 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 191026018101 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 191026018102 Walker A motif; other site 191026018103 ATP binding site [chemical binding]; other site 191026018104 Walker B motif; other site 191026018105 arginine finger; other site 191026018106 Peptidase family M41; Region: Peptidase_M41; pfam01434 191026018107 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 191026018108 dihydropteroate synthase; Region: DHPS; TIGR01496 191026018109 substrate binding pocket [chemical binding]; other site 191026018110 dimer interface [polypeptide binding]; other site 191026018111 inhibitor binding site; inhibition site 191026018112 Uncharacterized conserved protein [Function unknown]; Region: COG1624 191026018113 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 191026018114 YbbR-like protein; Region: YbbR; pfam07949 191026018115 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14314 191026018116 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 191026018117 active site 191026018118 substrate binding site [chemical binding]; other site 191026018119 metal binding site [ion binding]; metal-binding site 191026018120 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 191026018121 active site 191026018122 tetramer interface; other site 191026018123 Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198 191026018124 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 191026018125 ATP binding site [chemical binding]; other site 191026018126 putative Mg++ binding site [ion binding]; other site 191026018127 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 191026018128 ATP-binding site [chemical binding]; other site 191026018129 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 191026018130 anti sigma factor interaction site; other site 191026018131 regulatory phosphorylation site [posttranslational modification]; other site 191026018132 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840 191026018133 Smr domain; Region: Smr; pfam01713 191026018134 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 191026018135 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 191026018136 Walker A/P-loop; other site 191026018137 ATP binding site [chemical binding]; other site 191026018138 Q-loop/lid; other site 191026018139 ABC transporter signature motif; other site 191026018140 Walker B; other site 191026018141 D-loop; other site 191026018142 H-loop/switch region; other site 191026018143 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 191026018144 Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458 191026018145 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307 191026018146 Uncharacterized Fe-S protein [Energy production and conversion]; Region: COG1600 191026018147 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 191026018148 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 191026018149 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 191026018150 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 191026018151 CoA-ligase; Region: Ligase_CoA; pfam00549 191026018152 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 191026018153 CoA binding domain; Region: CoA_binding; pfam02629 191026018154 CoA-ligase; Region: Ligase_CoA; pfam00549 191026018155 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 191026018156 multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase; Reviewed; Region: cca; PRK10885 191026018157 active site 191026018158 NTP binding site [chemical binding]; other site 191026018159 metal binding triad [ion binding]; metal-binding site 191026018160 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 191026018161 Uncharacterized conserved protein [Function unknown]; Region: COG0398 191026018162 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 191026018163 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 191026018164 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 191026018165 ligand binding site [chemical binding]; other site 191026018166 flexible hinge region; other site 191026018167 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 191026018168 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 191026018169 ligand binding site [chemical binding]; other site 191026018170 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 191026018171 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 191026018172 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 191026018173 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 191026018174 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl17700 191026018175 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 191026018176 putative exosortase-associated protein, TIGR04073 family; Region: exo_TIGR04073 191026018177 Thioredoxin; Region: Thioredoxin_4; pfam13462 191026018178 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 191026018179 Methyltransferase domain; Region: Methyltransf_31; pfam13847 191026018180 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 191026018181 S-adenosylmethionine binding site [chemical binding]; other site 191026018182 NCAIR mutase (PurE)-related proteins [General function prediction only]; Region: COG1691 191026018183 AIR carboxylase; Region: AIRC; smart01001 191026018184 hypothetical protein; Provisional; Region: PRK04194 191026018185 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 191026018186 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 191026018187 NAD binding site [chemical binding]; other site 191026018188 homodimer interface [polypeptide binding]; other site 191026018189 active site 191026018190 substrate binding site [chemical binding]; other site 191026018191 conserved hypothetical protein; Region: TIGR02231 191026018192 N-terminal domain of unknown function (DUF4140); Region: DUF4140; pfam13600 191026018193 Domain of unknown function (DUF4139); Region: DUF4139; pfam13598 191026018194 Long-chain fatty acid transport protein [Lipid metabolism]; Region: FadL; COG2067 191026018195 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 191026018196 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 191026018197 RNA binding surface [nucleotide binding]; other site 191026018198 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 191026018199 S-adenosylmethionine binding site [chemical binding]; other site 191026018200 threonine synthase; Validated; Region: PRK06260 191026018201 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 191026018202 homodimer interface [polypeptide binding]; other site 191026018203 pyridoxal 5'-phosphate binding site [chemical binding]; other site 191026018204 catalytic residue [active] 191026018205 Protein of unknown function (DUF456); Region: DUF456; pfam04306 191026018206 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 191026018207 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 191026018208 acyl-activating enzyme (AAE) consensus motif; other site 191026018209 AMP binding site [chemical binding]; other site 191026018210 active site 191026018211 CoA binding site [chemical binding]; other site 191026018212 replicative DNA helicase; Region: DnaB; TIGR00665 191026018213 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 191026018214 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 191026018215 Walker A motif; other site 191026018216 ATP binding site [chemical binding]; other site 191026018217 Walker B motif; other site 191026018218 DNA binding loops [nucleotide binding] 191026018219 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 191026018220 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 191026018221 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 191026018222 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 191026018223 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 191026018224 Enoyl-[acyl-carrier-protein]; Region: FabI; COG0623 191026018225 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 191026018226 NAD binding site [chemical binding]; other site 191026018227 homotetramer interface [polypeptide binding]; other site 191026018228 homodimer interface [polypeptide binding]; other site 191026018229 substrate binding site [chemical binding]; other site 191026018230 active site 191026018231 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 191026018232 ATP binding site [chemical binding]; other site 191026018233 active site 191026018234 substrate binding site [chemical binding]; other site 191026018235 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 191026018236 histidinol dehydrogenase; Region: hisD; TIGR00069 191026018237 NAD binding site [chemical binding]; other site 191026018238 dimerization interface [polypeptide binding]; other site 191026018239 product binding site; other site 191026018240 substrate binding site [chemical binding]; other site 191026018241 zinc binding site [ion binding]; other site 191026018242 catalytic residues [active] 191026018243 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 191026018244 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 191026018245 GIY-YIG motif/motif A; other site 191026018246 active site 191026018247 catalytic site [active] 191026018248 putative DNA binding site [nucleotide binding]; other site 191026018249 metal binding site [ion binding]; metal-binding site 191026018250 UvrB/uvrC motif; Region: UVR; pfam02151 191026018251 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 191026018252 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 191026018253 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 191026018254 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 191026018255 3-polyprenyl-4-hydroxybenzoate decarboxylase [Coenzyme metabolism]; Region: UbiX; COG0163 191026018256 Flavoprotein; Region: Flavoprotein; pfam02441 191026018257 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 191026018258 ATP-grasp domain; Region: ATP-grasp; pfam02222 191026018259 Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757 191026018260 PII-like signaling protein [Signal transduction mechanisms]; Region: COG1993 191026018261 Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239 191026018262 Adenylyl cyclase (AC) class IV-like, a subgroup of the CYTH-like superfamily; Region: CYTH-like_AC_IV-like; cd07890 191026018263 putative active site [active] 191026018264 putative metal binding residues [ion binding]; other site 191026018265 signature motif; other site 191026018266 putative triphosphate binding site [ion binding]; other site 191026018267 dimer interface [polypeptide binding]; other site 191026018268 Uncharacterized conserved protein [Function unknown]; Region: COG2127 191026018269 ATP-dependent Clp protease ATP-binding subunit clpA; Region: ClpA; TIGR02639 191026018270 Clp amino terminal domain; Region: Clp_N; pfam02861 191026018271 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 191026018272 Walker A motif; other site 191026018273 ATP binding site [chemical binding]; other site 191026018274 Walker B motif; other site 191026018275 arginine finger; other site 191026018276 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 191026018277 Walker A motif; other site 191026018278 ATP binding site [chemical binding]; other site 191026018279 Walker B motif; other site 191026018280 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 191026018281 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 191026018282 TPR motif; other site 191026018283 binding surface 191026018284 Tetratricopeptide repeat; Region: TPR_12; pfam13424 191026018285 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 191026018286 binding surface 191026018287 TPR motif; other site 191026018288 Tetratricopeptide repeat; Region: TPR_12; pfam13424 191026018289 Tetratricopeptide repeat; Region: TPR_12; pfam13424 191026018290 Tetratricopeptide repeat; Region: TPR_12; pfam13424 191026018291 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 191026018292 binding surface 191026018293 TPR motif; other site 191026018294 Tetratricopeptide repeat; Region: TPR_12; pfam13424 191026018295 Tetratricopeptide repeat; Region: TPR_12; pfam13424 191026018296 Chemotaxis phosphatase, CheZ; Region: CheZ; cl01219 191026018297 NIL domain; Region: NIL; pfam09383 191026018298 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 191026018299 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 191026018300 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 191026018301 Tetratricopeptide repeat; Region: TPR_6; pfam13174 191026018302 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 191026018303 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 191026018304 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 191026018305 lipoprotein signal peptidase; Provisional; Region: PRK14787 191026018306 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 191026018307 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 191026018308 active site 191026018309 HIGH motif; other site 191026018310 nucleotide binding site [chemical binding]; other site 191026018311 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 191026018312 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 191026018313 active site 191026018314 KMSKS motif; other site 191026018315 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 191026018316 tRNA binding surface [nucleotide binding]; other site 191026018317 anticodon binding site; other site 191026018318 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 191026018319 Protein of unknown function (DUF493); Region: DUF493; pfam04359 191026018320 N-terminal putative catalytic domain of mainly uncharacterized prokaryotic proteins similar to archaeal thermoactive amylopullulanases; glycoside hydrolase family 57 (GH57); Region: GH57N_APU_like_1; cd10797 191026018321 Glycosyl hydrolase family 57; Region: Glyco_hydro_57; pfam03065 191026018322 active site 191026018323 catalytic site [active] 191026018324 Domain of unknown function (DUF3536); Region: DUF3536; pfam12055 191026018325 Metal-dependent hydrolases of the beta-lactamase superfamily II [General function prediction only]; Region: COG1237 191026018326 putative alpha-isopropylmalate/homocitrate synthase family transferase; Provisional; Region: PRK12344 191026018327 Desulfobacterium autotrophicum LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA3; cd07941 191026018328 active site 191026018329 catalytic residues [active] 191026018330 metal binding site [ion binding]; metal-binding site 191026018331 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 191026018332 aspartate kinase; Reviewed; Region: PRK06635 191026018333 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 191026018334 putative nucleotide binding site [chemical binding]; other site 191026018335 putative catalytic residues [active] 191026018336 putative Mg ion binding site [ion binding]; other site 191026018337 putative aspartate binding site [chemical binding]; other site 191026018338 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 191026018339 putative allosteric regulatory site; other site 191026018340 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 191026018341 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 191026018342 FOG: CBS domain [General function prediction only]; Region: COG0517 191026018343 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 191026018344 putative carbohydrate kinase; Provisional; Region: PRK10565 191026018345 YjeF-related protein N-terminus; Region: YjeF_N; pfam03853 191026018346 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 191026018347 putative substrate binding site [chemical binding]; other site 191026018348 putative ATP binding site [chemical binding]; other site 191026018349 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK14657 191026018350 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003 191026018351 active site 191026018352 hydrophilic channel; other site 191026018353 dimerization interface [polypeptide binding]; other site 191026018354 catalytic residues [active] 191026018355 active site lid [active] 191026018356 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 191026018357 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 191026018358 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 191026018359 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 191026018360 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 191026018361 putative CheA interaction surface; other site 191026018362 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 191026018363 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; pfam02559 191026018364 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 191026018365 ATP binding site [chemical binding]; other site 191026018366 putative Mg++ binding site [ion binding]; other site 191026018367 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 191026018368 nucleotide binding region [chemical binding]; other site 191026018369 ATP-binding site [chemical binding]; other site 191026018370 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 191026018371 SurA N-terminal domain; Region: SurA_N_3; cl07813 191026018372 peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059 191026018373 SurA N-terminal domain; Region: SurA_N; pfam09312 191026018374 PPIC-type PPIASE domain; Region: Rotamase_2; cl08278 191026018375 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 191026018376 non-specific DNA binding site [nucleotide binding]; other site 191026018377 salt bridge; other site 191026018378 sequence-specific DNA binding site [nucleotide binding]; other site 191026018379 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 191026018380 Recombination protein O N terminal; Region: RecO_N; pfam11967 191026018381 DNA repair protein RecO; Region: reco; TIGR00613 191026018382 Recombination protein O C terminal; Region: RecO_C; pfam02565 191026018383 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 191026018384 dimer interface [polypeptide binding]; other site 191026018385 motif 1; other site 191026018386 active site 191026018387 motif 2; other site 191026018388 motif 3; other site 191026018389 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 191026018390 Filamentous haemagglutinin family outer membrane protein; Region: DUF3739; pfam12545 191026018391 DALR anticodon binding domain; Region: DALR_1; pfam05746 191026018392 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 191026018393 potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496 191026018394 TrkA-N domain; Region: TrkA_N; pfam02254 191026018395 TrkA-C domain; Region: TrkA_C; pfam02080 191026018396 TrkA-N domain; Region: TrkA_N; pfam02254 191026018397 TrkA-C domain; Region: TrkA_C; pfam02080 191026018398 Cation transport protein; Region: TrkH; cl17365 191026018399 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 191026018400 Aspartate oxidase [Coenzyme metabolism]; Region: NadB; COG0029 191026018401 L-aspartate oxidase; Provisional; Region: PRK06175 191026018402 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 191026018403 quinolinate synthetase; Provisional; Region: PRK09375 191026018404 Nicotinate-nucleotide pyrophosphorylase [Coenzyme metabolism]; Region: NadC; COG0157 191026018405 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 191026018406 dimerization interface [polypeptide binding]; other site 191026018407 active site 191026018408 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 191026018409 MgtE intracellular N domain; Region: MgtE_N; smart00924 191026018410 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 191026018411 Divalent cation transporter; Region: MgtE; pfam01769 191026018412 adenylate kinase; Provisional; Region: PRK14529 191026018413 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 191026018414 AMP-binding site [chemical binding]; other site 191026018415 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 191026018416 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 191026018417 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 191026018418 Ligand Binding Site [chemical binding]; other site 191026018419 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 191026018420 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 191026018421 tRNA; other site 191026018422 putative tRNA binding site [nucleotide binding]; other site 191026018423 putative NADP binding site [chemical binding]; other site 191026018424 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 191026018425 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 191026018426 Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme metabolism]; Region: CysG; COG1648 191026018427 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 191026018428 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 191026018429 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 191026018430 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4641 191026018431 DUF based on E. rectale Gene description (DUF3880); Region: DUF3880; pfam12996 191026018432 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 191026018433 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 191026018434 Methyltransferase, chemotaxis proteins; Region: MeTrc; smart00138 191026018435 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 191026018436 HDOD domain; Region: HDOD; pfam08668 191026018437 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 191026018438 Zn2+ binding site [ion binding]; other site 191026018439 Mg2+ binding site [ion binding]; other site 191026018440 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 191026018441 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 191026018442 putative active site [active] 191026018443 heme pocket [chemical binding]; other site 191026018444 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 191026018445 dimer interface [polypeptide binding]; other site 191026018446 phosphorylation site [posttranslational modification] 191026018447 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 191026018448 ATP binding site [chemical binding]; other site 191026018449 Mg2+ binding site [ion binding]; other site 191026018450 G-X-G motif; other site 191026018451 recombination factor protein RarA; Reviewed; Region: PRK13342 191026018452 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 191026018453 Walker A motif; other site 191026018454 ATP binding site [chemical binding]; other site 191026018455 Walker B motif; other site 191026018456 arginine finger; other site 191026018457 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 191026018458 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 191026018459 RNA methyltransferase, RsmE family; Region: TIGR00046 191026018460 diaminopimelate decarboxylase; Region: lysA; TIGR01048 191026018461 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 191026018462 active site 191026018463 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 191026018464 substrate binding site [chemical binding]; other site 191026018465 catalytic residues [active] 191026018466 dimer interface [polypeptide binding]; other site 191026018467 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 191026018468 MutS domain I; Region: MutS_I; pfam01624 191026018469 MutS domain II; Region: MutS_II; pfam05188 191026018470 MutS domain III; Region: MutS_III; pfam05192 191026018471 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 191026018472 Walker A/P-loop; other site 191026018473 ATP binding site [chemical binding]; other site 191026018474 Q-loop/lid; other site 191026018475 ABC transporter signature motif; other site 191026018476 Walker B; other site 191026018477 D-loop; other site 191026018478 H-loop/switch region; other site 191026018479 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 191026018480 TPR motif; other site 191026018481 Tetratricopeptide repeat; Region: TPR_12; pfam13424 191026018482 binding surface 191026018483 TPR repeat; Region: TPR_11; pfam13414 191026018484 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 191026018485 binding surface 191026018486 TPR motif; other site 191026018487 Tfp pilus assembly protein PilF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilF; COG3063 191026018488 Protein of unknown function (DUF1049); Region: DUF1049; pfam06305 191026018489 FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275 191026018490 nucleotide binding site/active site [active] 191026018491 HIT family signature motif; other site 191026018492 catalytic residue [active] 191026018493 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 191026018494 DHH family; Region: DHH; pfam01368 191026018495 DHHA1 domain; Region: DHHA1; pfam02272 191026018496 FOG: CBS domain [General function prediction only]; Region: COG0517 191026018497 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 191026018498 tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617 191026018499 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 191026018500 active site 191026018501 NTP binding site [chemical binding]; other site 191026018502 metal binding triad [ion binding]; metal-binding site 191026018503 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 191026018504 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 191026018505 active site 191026018506 Int/Topo IB signature motif; other site 191026018507 LL-diaminopimelate aminotransferase; Provisional; Region: PRK09276 191026018508 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 191026018509 pyridoxal 5'-phosphate binding site [chemical binding]; other site 191026018510 homodimer interface [polypeptide binding]; other site 191026018511 catalytic residue [active] 191026018512 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 191026018513 catalytic center binding site [active] 191026018514 ATP binding site [chemical binding]; other site 191026018515 Ribosomal protein L24e/L24 is a ribosomal protein found in eukaryotes (L24) and in archaea (L24e, distinct from archaeal L24). L24e/L24 is located on the surface of the large subunit, adjacent to proteins L14 and L3, and near the translation factor...; Region: Ribosomal_L24e_L24; cl00909 191026018516 Class I aldolases; Region: Aldolase_Class_I; cl17187 191026018517 catalytic residue [active] 191026018518 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 191026018519 DsrE/DsrF-like family; Region: DrsE; cl00672 191026018520 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 191026018521 pyridoxal 5'-phosphate binding site [chemical binding]; other site 191026018522 catalytic residue [active] 191026018523 Staphylococcal nuclease homologue; Region: SNase; pfam00565 191026018524 Catalytic site; other site 191026018525 Preprotein translocase SecG subunit; Region: SecG; pfam03840 191026018526 triosephosphate isomerase; Provisional; Region: PRK14565 191026018527 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 191026018528 substrate binding site [chemical binding]; other site 191026018529 dimer interface [polypeptide binding]; other site 191026018530 catalytic triad [active] 191026018531 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 191026018532 Phosphoglycerate kinase; Region: PGK; pfam00162 191026018533 substrate binding site [chemical binding]; other site 191026018534 hinge regions; other site 191026018535 ADP binding site [chemical binding]; other site 191026018536 catalytic site [active] 191026018537 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 191026018538 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 191026018539 Coenzyme A binding pocket [chemical binding]; other site 191026018540 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 191026018541 isopentenyl-diphosphate delta-isomerase, type 1; Region: IPP_isom_1; TIGR02150 191026018542 nudix motif; other site 191026018543 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 191026018544 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 191026018545 active site 191026018546 dimerization interface [polypeptide binding]; other site 191026018547 rod shape-determining protein MreB; Provisional; Region: PRK13930 191026018548 MreB and similar proteins; Region: MreB_like; cd10225 191026018549 nucleotide binding site [chemical binding]; other site 191026018550 Mg binding site [ion binding]; other site 191026018551 putative protofilament interaction site [polypeptide binding]; other site 191026018552 RodZ interaction site [polypeptide binding]; other site 191026018553 GAF domain; Region: GAF; pfam01590 191026018554 GAF domain; Region: GAF_2; pfam13185 191026018555 GAF domain; Region: GAF_3; pfam13492 191026018556 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 191026018557 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 191026018558 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 191026018559 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 191026018560 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 191026018561 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 191026018562 molybdopterin cofactor binding site; other site 191026018563 4Fe-4S dicluster domain; Region: Fer4_11; pfam13247 191026018564 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168 191026018565 heme-binding residues [chemical binding]; other site 191026018566 Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281 191026018567 homodimer interaction site [polypeptide binding]; other site 191026018568 cofactor binding site; other site 191026018569 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 191026018570 phosphoglyceromutase; Provisional; Region: PRK05434 191026018571 iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090 191026018572 phenylacetate-CoA ligase; Region: PA_CoA_ligase; TIGR02155 191026018573 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 191026018574 acyl-activating enzyme (AAE) consensus motif; other site 191026018575 AMP binding site [chemical binding]; other site 191026018576 active site 191026018577 CoA binding site [chemical binding]; other site 191026018578 ACT domain-containing protein [General function prediction only]; Region: COG4747 191026018579 N-terminal ACT domain of a novel protein composed almost entirely of two tandem ACT domains; Region: ACT_Bt0572_1; cd04908 191026018580 C-terminal ACT domain of a novel protein composed of just two ACT domains; Region: ACT_Bt0572_2; cd04882 191026018581 Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139 191026018582 hypothetical protein; Reviewed; Region: PRK09588 191026018583 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 191026018584 putative binding surface; other site 191026018585 active site 191026018586 K+ potassium transporter; Region: K_trans; pfam02705 191026018587 dihydrodipicolinate reductase; Provisional; Region: PRK00048 191026018588 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 191026018589 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 191026018590 NAD-dependent DNA ligase (contains BRCT domain type II) [DNA replication, recombination, and repair]; Region: Lig; COG0272 191026018591 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cl03295 191026018592 nucleotide binding pocket [chemical binding]; other site 191026018593 K-X-D-G motif; other site 191026018594 catalytic site [active] 191026018595 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 191026018596 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 191026018597 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 191026018598 Dimer interface [polypeptide binding]; other site 191026018599 BRCT sequence motif; other site 191026018600 Ion channel; Region: Ion_trans_2; pfam07885 191026018601 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 191026018602 TrkA-N domain; Region: TrkA_N; pfam02254 191026018603 TrkA-C domain; Region: TrkA_C; pfam02080 191026018604 excinuclease ABC subunit B; Provisional; Region: PRK05298 191026018605 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 191026018606 ATP binding site [chemical binding]; other site 191026018607 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 191026018608 nucleotide binding region [chemical binding]; other site 191026018609 ATP-binding site [chemical binding]; other site 191026018610 Ultra-violet resistance protein B; Region: UvrB; pfam12344 191026018611 leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301 191026018612 Quinol:fumarate reductase (QFR) Type B subfamily, transmembrane subunit; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinone...; Region: QFR_TypeB_TM; cd00581 191026018613 Iron-sulfur protein interface; other site 191026018614 proximal heme binding site [chemical binding]; other site 191026018615 distal heme binding site [chemical binding]; other site 191026018616 dimer interface [polypeptide binding]; other site 191026018617 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 191026018618 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 191026018619 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 191026018620 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 191026018621 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 191026018622 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 191026018623 M20 Peptidase T like enzymes specifically cleave tripeptides; Region: M20_peptT_like; cd05683 191026018624 peptidase T-like protein; Region: PepT-like; TIGR01883 191026018625 metal binding site [ion binding]; metal-binding site 191026018626 putative dimer interface [polypeptide binding]; other site 191026018627 A bacterial subgroup of the C-type lectin-like (CTLD) domain; a subgroup of bacterial protein domains homologous to the carbohydrate-recognition domains (CRDs) of the C-type lectins; Region: CLECT_VCBS; cd03603 191026018628 ligand binding surface [chemical binding]; other site 191026018629 HupF/HypC family; Region: HupF_HypC; pfam01455 191026018630 coenzyme F420-reducing hydrogenase delta subunit (putative coenzyme F420 hydrogenase processing subunit); Region: frhD; TIGR00130 191026018631 Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062 191026018632 putative substrate-binding site; other site 191026018633 nickel binding site [ion binding]; other site 191026018634 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 191026018635 Nickel-dependent hydrogenase; Region: NiFeSe_Hases; pfam00374 191026018636 Ni,Fe-hydrogenase I small subunit [Energy production and conversion]; Region: HyaA; COG1740 191026018637 Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409 191026018638 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 191026018639 thymidylate kinase; Validated; Region: tmk; PRK00698 191026018640 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 191026018641 TMP-binding site; other site 191026018642 ATP-binding site [chemical binding]; other site 191026018643 Predicted HD-superfamily hydrolase [General function prediction only]; Region: COG3481 191026018644 YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492 191026018645 generic binding surface I; other site 191026018646 generic binding surface II; other site 191026018647 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 191026018648 Zn2+ binding site [ion binding]; other site 191026018649 Mg2+ binding site [ion binding]; other site 191026018650 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 191026018651 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 191026018652 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 191026018653 intersubunit interface [polypeptide binding]; other site 191026018654 active site 191026018655 zinc binding site [ion binding]; other site 191026018656 Na+ binding site [ion binding]; other site 191026018657 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 191026018658 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 191026018659 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 191026018660 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 191026018661 dimer interface [polypeptide binding]; other site 191026018662 conserved gate region; other site 191026018663 putative PBP binding loops; other site 191026018664 ABC-ATPase subunit interface; other site 191026018665 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 191026018666 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 191026018667 substrate binding pocket [chemical binding]; other site 191026018668 membrane-bound complex binding site; other site 191026018669 hinge residues; other site 191026018670 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 191026018671 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 191026018672 dimer interface [polypeptide binding]; other site 191026018673 conserved gate region; other site 191026018674 ABC-ATPase subunit interface; other site 191026018675 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 191026018676 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 191026018677 Zn2+ binding site [ion binding]; other site 191026018678 Mg2+ binding site [ion binding]; other site 191026018679 HAMP domain; Region: HAMP; pfam00672 191026018680 PAS fold; Region: PAS; pfam00989 191026018681 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 191026018682 putative active site [active] 191026018683 heme pocket [chemical binding]; other site 191026018684 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 191026018685 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 191026018686 dimer interface [polypeptide binding]; other site 191026018687 putative CheW interface [polypeptide binding]; other site 191026018688 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: DUF374; Region: LPLAT_DUF374-like; cd07983 191026018689 putative acyl-acceptor binding pocket; other site 191026018690 lipid A export permease/ATP-binding protein MsbA; Region: MsbA_lipidA; TIGR02203 191026018691 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 191026018692 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 191026018693 Walker A/P-loop; other site 191026018694 ATP binding site [chemical binding]; other site 191026018695 Q-loop/lid; other site 191026018696 ABC transporter signature motif; other site 191026018697 Walker B; other site 191026018698 D-loop; other site 191026018699 H-loop/switch region; other site 191026018700 SirA_like_N, a protein of unknown function with an N-terminal SirA-like domain. The SirA, YedF, YeeD protein family is present in bacteria as well as archaea. SirA (also known as UvrY, and YhhP) belongs to a family of a two-component response...; Region: SirA_like_N; cd03421 191026018701 selenium metabolism protein YedF; Region: selenium_YedF; TIGR03527 191026018702 CPxP motif; other site 191026018703 DsrE/DsrF-like family; Region: DrsE; pfam02635 191026018704 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 191026018705 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 191026018706 RNA binding surface [nucleotide binding]; other site 191026018707 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 191026018708 active site 191026018709 Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834 191026018710 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl17548 191026018711 L-2-amino-thiazoline-4-carboxylic acid hydrolase; Region: ATC_hydrolase; pfam14196 191026018712 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 191026018713 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 191026018714 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 191026018715 elongation factor P; Validated; Region: PRK00529 191026018716 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 191026018717 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 191026018718 RNA binding site [nucleotide binding]; other site 191026018719 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 191026018720 RNA binding site [nucleotide binding]; other site 191026018721 Dehydroquinase class II; Region: DHquinase_II; pfam01220 191026018722 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 191026018723 trimer interface [polypeptide binding]; other site 191026018724 active site 191026018725 dimer interface [polypeptide binding]; other site 191026018726 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 191026018727 G1 box; other site 191026018728 GTP/Mg2+ binding site [chemical binding]; other site 191026018729 Switch I region; other site 191026018730 G2 box; other site 191026018731 G3 box; other site 191026018732 Switch II region; other site 191026018733 G4 box; other site 191026018734 G5 box; other site 191026018735 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 191026018736 Predicted permeases [General function prediction only]; Region: COG0795 191026018737 Predicted permeases [General function prediction only]; Region: COG0795 191026018738 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 191026018739 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 191026018740 NMT1/THI5 like; Region: NMT1; pfam09084 191026018741 PAS domain S-box; Region: sensory_box; TIGR00229 191026018742 PAS domain; Region: PAS; smart00091 191026018743 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 191026018744 dimer interface [polypeptide binding]; other site 191026018745 phosphorylation site [posttranslational modification] 191026018746 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 191026018747 ATP binding site [chemical binding]; other site 191026018748 Mg2+ binding site [ion binding]; other site 191026018749 G-X-G motif; other site 191026018750 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 191026018751 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 191026018752 substrate binding pocket [chemical binding]; other site 191026018753 membrane-bound complex binding site; other site 191026018754 hinge residues; other site 191026018755 Micrococcal nuclease (thermonuclease) homologs [DNA replication, recombination, and repair]; Region: COG1525 191026018756 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 191026018757 Domain of unknown function (DUF4198); Region: DUF4198; pfam10670 191026018758 Response regulator receiver domain; Region: Response_reg; pfam00072 191026018759 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 191026018760 active site 191026018761 phosphorylation site [posttranslational modification] 191026018762 intermolecular recognition site; other site 191026018763 Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437 191026018764 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 191026018765 active site 191026018766 phosphorylation site [posttranslational modification] 191026018767 intermolecular recognition site; other site 191026018768 dimerization interface [polypeptide binding]; other site 191026018769 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 191026018770 Zn2+ binding site [ion binding]; other site 191026018771 Mg2+ binding site [ion binding]; other site 191026018772 Helix-turn-helix domain; Region: HTH_28; pfam13518 191026018773 Winged helix-turn helix; Region: HTH_29; pfam13551 191026018774 Homeodomain-like domain; Region: HTH_32; pfam13565 191026018775 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 191026018776 Integrase core domain; Region: rve; pfam00665 191026018777 Integrase core domain; Region: rve_3; pfam13683 191026018778 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 191026018779 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 191026018780 Transposase; Region: HTH_Tnp_1; cl17663 191026018781 Integrase core domain; Region: rve; pfam00665 191026018782 Integrase core domain; Region: rve_3; pfam13683 191026018783 Methylamine utilisation protein MauE; Region: MauE; pfam07291 191026018784 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 191026018785 active site residue [active] 191026018786 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 191026018787 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 191026018788 putative substrate translocation pore; other site 191026018789 Cupin domain; Region: Cupin_2; pfam07883 191026018790 3,4-dihydroxy-2-butanone 4-phosphate synthase; Provisional; Region: ribB; PRK03353 191026018791 3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108 191026018792 argininosuccinate lyase; Provisional; Region: PRK00855 191026018793 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 191026018794 active sites [active] 191026018795 tetramer interface [polypeptide binding]; other site 191026018796 argininosuccinate synthase; Provisional; Region: PRK13820 191026018797 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 191026018798 ANP binding site [chemical binding]; other site 191026018799 Substrate Binding Site II [chemical binding]; other site 191026018800 Substrate Binding Site I [chemical binding]; other site 191026018801 ornithine carbamoyltransferase; Provisional; Region: PRK00779 191026018802 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 191026018803 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 191026018804 Uncharacterized protein family UPF0054; Region: UPF0054; pfam02130 191026018805 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 191026018806 PhoH-like protein; Region: PhoH; pfam02562 191026018807 Response regulator receiver domain; Region: Response_reg; pfam00072 191026018808 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 191026018809 active site 191026018810 phosphorylation site [posttranslational modification] 191026018811 intermolecular recognition site; other site 191026018812 dimerization interface [polypeptide binding]; other site 191026018813 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 191026018814 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 191026018815 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 191026018816 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 191026018817 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 191026018818 Na binding site [ion binding]; other site 191026018819 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 191026018820 dimer interface [polypeptide binding]; other site 191026018821 substrate binding site [chemical binding]; other site 191026018822 phosphomethylpyrimidine kinase; Provisional; Region: PRK08573 191026018823 ATP binding site [chemical binding]; other site 191026018824 Putative aldolase; Region: Aldolase_2; pfam10120 191026018825 uncharacterized radical SAM protein YgiQ; Region: SAM_YgiQ; TIGR03904 191026018826 Radical SAM N-terminal; Region: Radical_SAM_N; pfam08497 191026018827 Domain of unknown function (DUF3362); Region: DUF3362; pfam11842 191026018828 Acetolactate synthase, small (regulatory) subunit [Amino acid transport and metabolism]; Region: IlvH; COG0440 191026018829 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 191026018830 putative valine binding site [chemical binding]; other site 191026018831 dimer interface [polypeptide binding]; other site 191026018832 acetolactate synthase catalytic subunit; Validated; Region: PRK08155 191026018833 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 191026018834 PYR/PP interface [polypeptide binding]; other site 191026018835 dimer interface [polypeptide binding]; other site 191026018836 TPP binding site [chemical binding]; other site 191026018837 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 191026018838 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 191026018839 TPP-binding site [chemical binding]; other site 191026018840 dimer interface [polypeptide binding]; other site 191026018841 Methyltransferase domain; Region: Methyltransf_23; pfam13489 191026018842 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 191026018843 S-adenosylmethionine binding site [chemical binding]; other site 191026018844 Predicted glycosyl transferase [General function prediction only]; Region: COG4671 191026018845 Predicted glycosyl transferase [General function prediction only]; Region: COG4671 191026018846 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 191026018847 This is a family of GT1 glycosyltransferases found specifically in certain bacteria. amsK in Erwinia amylovora, has been reported to be involved in the biosynthesis of amylovoran, a exopolysaccharide acting as a virulence factor; Region: GT1_amsK_like; cd03799 191026018848 putative ADP-binding pocket [chemical binding]; other site 191026018849 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 191026018850 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 191026018851 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 191026018852 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 191026018853 catalytic core [active] 191026018854 Predicted glycosyl transferase [General function prediction only]; Region: COG4671 191026018855 Glycosyltransferase family 28 C-terminal domain; Region: Glyco_tran_28_C; cl17369 191026018856 Putative catalytic domain of uncharacterized bacterial proteins from the carbohydrate esterase 4 superfamily; Region: CE4_u4; cd10928 191026018857 NodB motif; other site 191026018858 putative active site [active] 191026018859 putative catalytic site [active] 191026018860 putative Zn binding site [ion binding]; other site 191026018861 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 191026018862 FtsX-like permease family; Region: FtsX; pfam02687 191026018863 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 191026018864 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 191026018865 Walker A/P-loop; other site 191026018866 ATP binding site [chemical binding]; other site 191026018867 Q-loop/lid; other site 191026018868 ABC transporter signature motif; other site 191026018869 Walker B; other site 191026018870 D-loop; other site 191026018871 H-loop/switch region; other site 191026018872 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 191026018873 PA: Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain; Region: PA; cl08238 191026018874 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 191026018875 metal binding site [ion binding]; metal-binding site 191026018876 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492 191026018877 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 191026018878 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 191026018879 FtsX-like permease family; Region: FtsX; pfam02687 191026018880 Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; cl05126 191026018881 Domain of unknown function (DUF3391); Region: DUF3391; pfam11871 191026018882 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 191026018883 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 191026018884 Zn2+ binding site [ion binding]; other site 191026018885 Mg2+ binding site [ion binding]; other site 191026018886 Hpt domain; Region: Hpt; pfam01627 191026018887 putative binding surface; other site 191026018888 active site 191026018889 Tim44-like domain; Region: Tim44; pfam04280 191026018890 Response regulator receiver domain; Region: Response_reg; pfam00072 191026018891 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 191026018892 active site 191026018893 phosphorylation site [posttranslational modification] 191026018894 intermolecular recognition site; other site 191026018895 dimerization interface [polypeptide binding]; other site 191026018896 DMAP1-binding Domain; Region: DMAP_binding; pfam06464 191026018897 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 191026018898 Zn2+ binding site [ion binding]; other site 191026018899 Mg2+ binding site [ion binding]; other site 191026018900 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 191026018901 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 191026018902 YfhG lipoprotein; Region: Lipoprotein_20; cl08141 191026018903 HAD superfamily, subfamily IIIB (Acid phosphatase); Region: Acid_phosphat_B; cl17236 191026018904 YibE/F-like protein; Region: YibE_F; pfam07907 191026018905 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cl15837 191026018906 Alkaline phosphatase homologues; Region: alkPPc; smart00098 191026018907 active site 191026018908 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cl15837 191026018909 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168 191026018910 heme-binding residues [chemical binding]; other site 191026018911 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168 191026018912 heme-binding residues [chemical binding]; other site 191026018913 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168 191026018914 heme-binding residues [chemical binding]; other site 191026018915 Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512 191026018916 4Fe-4S dicluster domain; Region: Fer4_17; pfam13534 191026018917 NQR2, RnfD, RnfE family; Region: NQR2_RnfD_RnfE; pfam03116 191026018918 FMN-binding domain; Region: FMN_bind; cl01081 191026018919 electron transport complex RsxE subunit; Provisional; Region: PRK12405 191026018920 Predicted NADH:ubiquinone oxidoreductase, subunit RnfA [Energy production and conversion]; Region: RnfA; COG4657 191026018921 electron transport complex, RnfABCDGE type, B subunit; Region: rnfB; TIGR01944 191026018922 putative glutamate synthase subunit beta; Provisional; Region: PRK12770 191026018923 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 191026018924 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; pfam09723 191026018925 Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009 191026018926 Transglycosylase; Region: Transgly; pfam00912 191026018927 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 191026018928 Glutamine phosphoribosylpyrophosphate amidotransferase [Nucleotide transport and metabolism]; Region: PurF; COG0034 191026018929 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 191026018930 active site 191026018931 tetramer interface [polypeptide binding]; other site 191026018932 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 191026018933 active site 191026018934 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 191026018935 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 191026018936 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 191026018937 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 191026018938 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 191026018939 ATP-grasp domain; Region: ATP-grasp_4; cl17255 191026018940 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 191026018941 IMP binding site; other site 191026018942 dimer interface [polypeptide binding]; other site 191026018943 interdomain contacts; other site 191026018944 partial ornithine binding site; other site 191026018945 FeoA domain; Region: FeoA; pfam04023 191026018946 SlyX; Region: SlyX; pfam04102 191026018947 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 191026018948 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 191026018949 active site 191026018950 HIGH motif; other site 191026018951 KMSKS motif; other site 191026018952 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 191026018953 anticodon binding site; other site 191026018954 tRNA binding surface [nucleotide binding]; other site 191026018955 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 191026018956 dimer interface [polypeptide binding]; other site 191026018957 putative tRNA-binding site [nucleotide binding]; other site 191026018958 PSP1 C-terminal conserved region; Region: PSP1; cl00770 191026018959 Response regulator receiver domain; Region: Response_reg; pfam00072 191026018960 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 191026018961 active site 191026018962 phosphorylation site [posttranslational modification] 191026018963 intermolecular recognition site; other site 191026018964 dimerization interface [polypeptide binding]; other site 191026018965 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 191026018966 Competence protein; Region: Competence; pfam03772 191026018967 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 191026018968 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 191026018969 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 191026018970 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 191026018971 hinge; other site 191026018972 active site 191026018973 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 191026018974 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 191026018975 tetramer interface [polypeptide binding]; other site 191026018976 heme binding pocket [chemical binding]; other site 191026018977 NADPH binding site [chemical binding]; other site 191026018978 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 191026018979 metal binding site 2 [ion binding]; metal-binding site 191026018980 putative DNA binding helix; other site 191026018981 metal binding site 1 [ion binding]; metal-binding site 191026018982 dimer interface [polypeptide binding]; other site 191026018983 structural Zn2+ binding site [ion binding]; other site 191026018984 selenocysteine-specific elongation factor SelB; Region: selB; TIGR00475 191026018985 SelB, the dedicated elongation factor for delivery of selenocysteinyl-tRNA to the ribosome; Region: SelB; cd04171 191026018986 G1 box; other site 191026018987 putative GEF interaction site [polypeptide binding]; other site 191026018988 GTP/Mg2+ binding site [chemical binding]; other site 191026018989 Switch I region; other site 191026018990 G2 box; other site 191026018991 G3 box; other site 191026018992 Switch II region; other site 191026018993 G4 box; other site 191026018994 G5 box; other site 191026018995 selB_II: this subfamily represents the domain of elongation factor SelB, homologous to domain II of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several...; Region: selB_II; cd03696 191026018996 This family represents the domain of elongation factor SelB, homologous to domain III of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several elements:...; Region: selB_III; cd04094 191026018997 Elongation factor SelB, winged helix; Region: SelB-wing_2; pfam09106 191026018998 Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107 191026018999 M18 Peptidase Aminopeptidase I; Region: M18_API; cd05659 191026019000 Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127 191026019001 oligomer interface [polypeptide binding]; other site 191026019002 putative active site [active] 191026019003 metal binding site [ion binding]; metal-binding site 191026019004 selenocysteine synthase; Provisional; Region: PRK04311 191026019005 Selenocysteine synthase N terminal; Region: Se-cys_synth_N; pfam12390 191026019006 Selenocysteine synthase [seryl-tRNASer selenium transferase] [Amino acid transport and metabolism]; Region: SelA; COG1921 191026019007 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 191026019008 catalytic residue [active] 191026019009 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 191026019010 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 191026019011 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 191026019012 Mechanosensitive ion channel; Region: MS_channel; pfam00924 191026019013 Conserved TM helix; Region: TM_helix; pfam05552 191026019014 Mechanosensitive ion channel; Region: MS_channel; pfam00924 191026019015 Phophatidylserine decarboxylase; Region: PSDC; pfam12588 191026019016 Phosphatidylserine decarboxylase; Region: PS_Dcarbxylase; pfam02666 191026019017 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme 191026019018 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme 191026019019 Fe-S-cluster-containing hydrogenase components 2 [Energy production and conversion]; Region: HycB; COG1142 191026019020 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 191026019021 [FeFe] hydrogenase, group A; Region: FeFe_hydrog_A; TIGR02512 191026019022 4Fe-4S binding domain; Region: Fer4; pfam00037 191026019023 Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906 191026019024 Iron hydrogenase small subunit; Region: Fe_hyd_SSU; pfam02256 191026019025 Fe-S-cluster-containing hydrogenase components 2 [Energy production and conversion]; Region: HycB; COG1142 191026019026 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 191026019027 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 191026019028 core domain interface [polypeptide binding]; other site 191026019029 delta subunit interface [polypeptide binding]; other site 191026019030 epsilon subunit interface [polypeptide binding]; other site 191026019031 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 191026019032 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 191026019033 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 191026019034 Walker A motif; other site 191026019035 ATP binding site [chemical binding]; other site 191026019036 Walker B motif; other site 191026019037 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 191026019038 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 191026019039 alternate F1F0 ATPase, F0 subunit B; Region: alt_F1F0_F0_B; TIGR03321 191026019040 F0F1 ATP synthase subunit C; Provisional; Region: PRK13468 191026019041 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 191026019042 ATP synthase A chain; Region: ATP-synt_A; cl00413 191026019043 N-ATPase, AtpR subunit; Region: AtpR; pfam12966 191026019044 Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; cl09754 191026019045 F0F1 ATP synthase subunit epsilon; Validated; Region: PRK06228 191026019046 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 191026019047 gamma subunit interface [polypeptide binding]; other site 191026019048 epsilon subunit interface [polypeptide binding]; other site 191026019049 LBP interface [polypeptide binding]; other site 191026019050 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 191026019051 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 191026019052 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 191026019053 alpha subunit interaction interface [polypeptide binding]; other site 191026019054 Walker A motif; other site 191026019055 ATP binding site [chemical binding]; other site 191026019056 Walker B motif; other site 191026019057 inhibitor binding site; inhibition site 191026019058 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 191026019059 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 191026019060 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 191026019061 ATP binding site [chemical binding]; other site 191026019062 putative Mg++ binding site [ion binding]; other site 191026019063 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 191026019064 nucleotide binding region [chemical binding]; other site 191026019065 ATP-binding site [chemical binding]; other site 191026019066 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 191026019067 HRDC domain; Region: HRDC; pfam00570 191026019068 Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668 191026019069 Predicted transcriptional regulator [Transcription]; Region: COG3905 191026019070 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 191026019071 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 191026019072 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 191026019073 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 191026019074 Low molecular weight phosphatase family; Region: LMWPc; cd00115 191026019075 active site 191026019076 ABC transporter substrate binding protein; Region: ABC_sub_bind; cl17301 191026019077 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 191026019078 Ligand Binding Site [chemical binding]; other site 191026019079 GTPase RsgA; Reviewed; Region: PRK01889 191026019080 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 191026019081 GTPase/Zn-binding domain interface [polypeptide binding]; other site 191026019082 GTP/Mg2+ binding site [chemical binding]; other site 191026019083 G4 box; other site 191026019084 G5 box; other site 191026019085 G1 box; other site 191026019086 Switch I region; other site 191026019087 G2 box; other site 191026019088 G3 box; other site 191026019089 Switch II region; other site 191026019090 Esterase-like activity of phytase; Region: Phytase-like; pfam13449 191026019091 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 191026019092 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 191026019093 substrate binding pocket [chemical binding]; other site 191026019094 membrane-bound complex binding site; other site 191026019095 hinge residues; other site 191026019096 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 191026019097 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 191026019098 putative active site [active] 191026019099 heme pocket [chemical binding]; other site 191026019100 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 191026019101 dimer interface [polypeptide binding]; other site 191026019102 phosphorylation site [posttranslational modification] 191026019103 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 191026019104 ATP binding site [chemical binding]; other site 191026019105 Mg2+ binding site [ion binding]; other site 191026019106 G-X-G motif; other site 191026019107 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 191026019108 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 191026019109 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762 191026019110 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 191026019111 Ligand Binding Site [chemical binding]; other site 191026019112 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 191026019113 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 191026019114 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 191026019115 Catalytic site [active] 191026019116 DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609 191026019117 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 191026019118 active site 191026019119 DNA binding site [nucleotide binding] 191026019120 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 191026019121 TPR repeat; Region: TPR_11; pfam13414 191026019122 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 191026019123 TPR motif; other site 191026019124 TPR repeat; Region: TPR_11; pfam13414 191026019125 binding surface 191026019126 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 191026019127 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 191026019128 ATP-grasp domain; Region: ATP-grasp_4; cl17255 191026019129 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 191026019130 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 191026019131 Acetyl-CoA carboxylase beta subunit [Lipid metabolism]; Region: AccD; COG0777 191026019132 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 191026019133 N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; cl17549 191026019134 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 191026019135 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; Region: MATE_NorM_like; cd13137 191026019136 Uncharacterized conserved protein (DUF2156); Region: DUF2156; cl12090 191026019137 Uncharacterized conserved protein [Function unknown]; Region: COG3379 191026019138 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 191026019139 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 191026019140 Part of AAA domain; Region: AAA_19; pfam13245 191026019141 Family description; Region: UvrD_C_2; pfam13538 191026019142 thiamine monophosphate kinase; Provisional; Region: PRK05731 191026019143 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 191026019144 ATP binding site [chemical binding]; other site 191026019145 dimerization interface [polypeptide binding]; other site 191026019146 Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281 191026019147 homodimer interaction site [polypeptide binding]; other site 191026019148 cofactor binding site; other site 191026019149 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 191026019150 rRNA binding site [nucleotide binding]; other site 191026019151 predicted 30S ribosome binding site; other site 191026019152 RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399 191026019153 ketol-acid reductoisomerase; Provisional; Region: PRK05479 191026019154 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 191026019155 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 191026019156 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 191026019157 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 191026019158 putative valine binding site [chemical binding]; other site 191026019159 dimer interface [polypeptide binding]; other site 191026019160 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 191026019161 acetolactate synthase 3 catalytic subunit; Reviewed; Region: PRK06048 191026019162 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 191026019163 PYR/PP interface [polypeptide binding]; other site 191026019164 dimer interface [polypeptide binding]; other site 191026019165 TPP binding site [chemical binding]; other site 191026019166 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 191026019167 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 191026019168 TPP-binding site [chemical binding]; other site 191026019169 dimer interface [polypeptide binding]; other site 191026019170 Uncharacterized ACR, YggU family COG1872; Region: DUF167; pfam02594 191026019171 DivIVA protein; Region: DivIVA; pfam05103 191026019172 DivIVA domain; Region: DivI1A_domain; TIGR03544 191026019173 YGGT family; Region: YGGT; pfam02325 191026019174 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 191026019175 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 191026019176 active site 191026019177 motif I; other site 191026019178 motif II; other site 191026019179 twin arginine translocase protein A; Provisional; Region: tatA; PRK14859 191026019180 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 191026019181 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 191026019182 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 191026019183 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 191026019184 active site 191026019185 (T/H)XGH motif; other site 191026019186 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 191026019187 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 191026019188 S-adenosylmethionine binding site [chemical binding]; other site 191026019189 Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236 191026019190 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 191026019191 Beta-Casp domain; Region: Beta-Casp; smart01027 191026019192 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 191026019193 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 191026019194 EamA-like transporter family; Region: EamA; pfam00892 191026019195 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 191026019196 molybdate ABC transporter periplasmic substrate-binding protein; Provisional; Region: PRK04168 191026019197 tungstate ABC transporter binding protein WtpA; Region: tungstate_WtpA; TIGR03730 191026019198 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 191026019199 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 191026019200 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 191026019201 Heparinase II/III-like protein; Region: Hepar_II_III; pfam07940 191026019202 putative secretion ATPase, PEP-CTERM locus subfamily; Region: pepcterm_ATPase; TIGR03015 191026019203 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 191026019204 Walker A motif; other site 191026019205 ATP binding site [chemical binding]; other site 191026019206 Walker B motif; other site 191026019207 arginine finger; other site 191026019208 exopolysaccharide/PEP-CTERM locus tyrosine autokinase; Region: pepcterm_TyrKin; TIGR03018 191026019209 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 191026019210 polysaccharide chain length determinant protein, PEP-CTERM locus subfamily; Region: pepcterm_ChnLen; TIGR03007 191026019211 Chain length determinant protein; Region: Wzz; cl15801 191026019212 Actin cytoskeleton-regulatory complex protein END3; Region: End3; pfam12761 191026019213 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 191026019214 Chain length determinant protein; Region: Wzz; cl15801 191026019215 uncharacterized protein, PEP-CTERM system associated; Region: pepcterm_hypo_1; TIGR03016 191026019216 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 191026019217 putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027 191026019218 SLBB domain; Region: SLBB; pfam10531 191026019219 Undecaprenyl-phosphate glucose phosphotransferase; Region: WcaJ_sugtrans; TIGR03023 191026019220 Bacterial sugar transferase; Region: Bac_transf; pfam02397 191026019221 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 191026019222 binding surface 191026019223 Tetratricopeptide repeat; Region: TPR_16; pfam13432 191026019224 TPR motif; other site 191026019225 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 191026019226 binding surface 191026019227 TPR motif; other site 191026019228 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 191026019229 binding surface 191026019230 TPR motif; other site 191026019231 TPR repeat; Region: TPR_11; pfam13414 191026019232 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 191026019233 binding surface 191026019234 TPR motif; other site 191026019235 TPR repeat; Region: TPR_11; pfam13414 191026019236 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 191026019237 TPR motif; other site 191026019238 binding surface 191026019239 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 191026019240 binding surface 191026019241 Tetratricopeptide repeat; Region: TPR_16; pfam13432 191026019242 TPR motif; other site 191026019243 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 191026019244 TPR motif; other site 191026019245 binding surface 191026019246 Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895 191026019247 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 191026019248 binding surface 191026019249 TPR motif; other site 191026019250 exosortase D, VPLPA-CTERM-specific; Region: exosort_VPLPA; TIGR04152 191026019251 Predicted membrane protein [Function unknown]; Region: COG4083; cl15694 191026019252 Protein of unknown function (DUF3485); Region: DUF3485; pfam11984 191026019253 Heparinase II/III-like protein; Region: Hepar_II_III; pfam07940 191026019254 O-Antigen ligase; Region: Wzy_C; cl04850 191026019255 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 191026019256 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 191026019257 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 191026019258 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the GGDEF (DiGuanylate-Cyclase (DGC)) domain. The GGDEF domain has been suggested to be homologous to the adenylyl cyclase catalytic domain and...; Region: CBS_pair_GGDEF_assoc; cd04598 191026019259 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 191026019260 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 191026019261 metal binding site [ion binding]; metal-binding site 191026019262 active site 191026019263 I-site; other site 191026019264 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 191026019265 AAA domain; Region: AAA_30; pfam13604 191026019266 Family description; Region: UvrD_C_2; pfam13538 191026019267 recombination protein RecR; Reviewed; Region: recR; PRK00076 191026019268 RecR protein; Region: RecR; pfam02132 191026019269 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 191026019270 active site 191026019271 metal binding site [ion binding]; metal-binding site 191026019272 hypothetical protein; Validated; Region: PRK00153 191026019273 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14959 191026019274 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 191026019275 Walker A motif; other site 191026019276 ATP binding site [chemical binding]; other site 191026019277 Walker B motif; other site 191026019278 arginine finger; other site 191026019279 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 191026019280 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 191026019281 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 191026019282 homodimer interface [polypeptide binding]; other site 191026019283 substrate-cofactor binding pocket; other site 191026019284 catalytic residue [active] 191026019285 N-terminal Early set domain associated with the catalytic domain of isoamylase-like (also called glycogen 6-glucanohydrolase) proteins; Region: E_set_Isoamylase_like_N; cd07184 191026019286 aminotransferase; Validated; Region: PRK08175 191026019287 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 191026019288 pyridoxal 5'-phosphate binding site [chemical binding]; other site 191026019289 homodimer interface [polypeptide binding]; other site 191026019290 catalytic residue [active] 191026019291 homoserine dehydrogenase; Provisional; Region: PRK06349 191026019292 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 191026019293 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 191026019294 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 191026019295 cofactor-independent phosphoglycerate mutase; Provisional; Region: PRK04200 191026019296 2,3-bisphosphoglycerate-independent phosphoglycerate mutase; Region: PhosphMutase; cl17294 191026019297 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 191026019298 active site 191026019299 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 191026019300 Protein of unknown function (DUF2867); Region: DUF2867; pfam11066 191026019301 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 191026019302 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 191026019303 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 191026019304 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168 191026019305 heme-binding residues [chemical binding]; other site 191026019306 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 191026019307 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 191026019308 Walker A/P-loop; other site 191026019309 ATP binding site [chemical binding]; other site 191026019310 Q-loop/lid; other site 191026019311 ABC transporter signature motif; other site 191026019312 Walker B; other site 191026019313 D-loop; other site 191026019314 H-loop/switch region; other site 191026019315 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 191026019316 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 191026019317 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 191026019318 TM-ABC transporter signature motif; other site 191026019319 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 191026019320 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 191026019321 TM-ABC transporter signature motif; other site 191026019322 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 191026019323 Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353 191026019324 putative ligand binding site [chemical binding]; other site 191026019325 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 191026019326 active site 191026019327 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 191026019328 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 191026019329 metal binding site [ion binding]; metal-binding site 191026019330 active site 191026019331 I-site; other site 191026019332 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 191026019333 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 191026019334 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01096 191026019335 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; smart00471 191026019336 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 191026019337 mercuric reductase; Validated; Region: PRK06370 191026019338 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 191026019339 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 191026019340 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 191026019341 Glucokinase; Region: Glucokinase; cl17310 191026019342 glucokinase, proteobacterial type; Region: glk; TIGR00749 191026019343 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 191026019344 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 191026019345 ligand binding site [chemical binding]; other site 191026019346 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 191026019347 Maf-like protein; Reviewed; Region: PRK00078 191026019348 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 191026019349 active site 191026019350 dimer interface [polypeptide binding]; other site 191026019351 Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878 191026019352 PAS fold; Region: PAS_4; pfam08448 191026019353 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 191026019354 PAS domain; Region: PAS_9; pfam13426 191026019355 putative active site [active] 191026019356 heme pocket [chemical binding]; other site 191026019357 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 191026019358 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 191026019359 metal binding site [ion binding]; metal-binding site 191026019360 active site 191026019361 I-site; other site 191026019362 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 191026019363 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 191026019364 tetramer interfaces [polypeptide binding]; other site 191026019365 binuclear metal-binding site [ion binding]; other site 191026019366 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 191026019367 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 191026019368 ligand binding site [chemical binding]; other site 191026019369 tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800 191026019370 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 191026019371 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 191026019372 TolA protein; Region: tolA_full; TIGR02794 191026019373 TonB C terminal; Region: TonB_2; pfam13103 191026019374 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 191026019375 TolR protein; Region: tolR; TIGR02801 191026019376 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 191026019377 NAD-dependent deacetylase; Provisional; Region: PRK00481 191026019378 SIR2 family of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2-fam; cd01407 191026019379 NAD+ binding site [chemical binding]; other site 191026019380 substrate binding site [chemical binding]; other site 191026019381 Zn binding site [ion binding]; other site 191026019382 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase; Region: PHP_HisPPase; cd07432 191026019383 active site 191026019384 hypothetical protein; Provisional; Region: PRK06361 191026019385 Bifunctional nuclease; Region: DNase-RNase; pfam02577 191026019386 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14337 191026019387 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 191026019388 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 191026019389 FeS/SAM binding site; other site 191026019390 TRAM domain; Region: TRAM; cl01282 191026019391 Ketosteroid isomerase homolog [Function unknown]; Region: COG4319 191026019392 SnoaL-like domain; Region: SnoaL_3; pfam13474 191026019393 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 191026019394 Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125 191026019395 active site 191026019396 Phosphotransferase enzyme family; Region: APH; pfam01636 191026019397 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 191026019398 Ribokinase-like subgroup A. Found in bacteria and archaea, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_A; cd01942 191026019399 substrate binding site [chemical binding]; other site 191026019400 ATP binding site [chemical binding]; other site 191026019401 Uncharacterized protein involved in tolerance to divalent cations [Inorganic ion transport and metabolism]; Region: CutA; COG1324 191026019402 Cytochrome c; Region: Cytochrom_C; cl11414 191026019403 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 191026019404 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 191026019405 minor groove reading motif; other site 191026019406 helix-hairpin-helix signature motif; other site 191026019407 substrate binding pocket [chemical binding]; other site 191026019408 active site 191026019409 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 191026019410 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 191026019411 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 191026019412 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 191026019413 putative active site [active] 191026019414 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK11468 191026019415 Dak1 domain; Region: Dak1; pfam02733 191026019416 DAK2 domain; Region: Dak2; cl03685 191026019417 dihydroxyacetone kinase subunit M; Provisional; Region: PRK11377 191026019418 dihydroxyacetone kinase, phosphotransfer subunit; Region: dha_pts; TIGR02364 191026019419 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 191026019420 regulatory protein interface [polypeptide binding]; other site 191026019421 active site 191026019422 regulatory phosphorylation site [posttranslational modification]; other site 191026019423 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 191026019424 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 191026019425 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 191026019426 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 191026019427 Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412 191026019428 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 191026019429 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 191026019430 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 191026019431 Iron-containing alcohol dehydrogenases-like; Region: Fe-ADH1; cd08185 191026019432 putative active site [active] 191026019433 metal binding site [ion binding]; metal-binding site 191026019434 AMIN domain; Region: AMIN; pfam11741 191026019435 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 191026019436 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 191026019437 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 191026019438 active site 191026019439 CoA binding domain; Region: CoA_binding_2; pfam13380 191026019440 Flagellin N-methylase; Region: FliB; pfam03692 191026019441 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 191026019442 HSP70 interaction site [polypeptide binding]; other site 191026019443 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141 191026019444 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 191026019445 putative active site [active] 191026019446 oxyanion strand; other site 191026019447 catalytic triad [active] 191026019448 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 191026019449 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 191026019450 substrate binding site [chemical binding]; other site 191026019451 glutamase interaction surface [polypeptide binding]; other site 191026019452 PPIC-type PPIASE domain; Region: Rotamase_2; cl08278 191026019453 Virulence protein RhuM family; Region: Virulence_RhuM; pfam13310 191026019454 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 191026019455 Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439 191026019456 PAP2_like_4 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_4; cd03395 191026019457 active site 191026019458 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 191026019459 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 191026019460 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 191026019461 dimer interface [polypeptide binding]; other site 191026019462 active site 191026019463 glycine-pyridoxal phosphate binding site [chemical binding]; other site 191026019464 folate binding site [chemical binding]; other site 191026019465 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 191026019466 chromosome replication initiation inhibitor protein; Validated; Region: PRK03635 191026019467 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 191026019468 The C-terminal substrate binding domain of LysR-type transcriptional regulator, ArgP (IciA), for arginine exporter (ArgO); contains the type 2 periplasmic binding fold; Region: PBP2_IciA_ArgP; cd08428 191026019469 putative dimerization interface [polypeptide binding]; other site 191026019470 Lysine efflux permease [General function prediction only]; Region: COG1279 191026019471 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 191026019472 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 191026019473 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 191026019474 Ligand binding site; other site 191026019475 Putative Catalytic site; other site 191026019476 DXD motif; other site 191026019477 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 191026019478 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 191026019479 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 191026019480 Walker A motif; other site 191026019481 ATP binding site [chemical binding]; other site 191026019482 Walker B motif; other site 191026019483 arginine finger; other site 191026019484 Putative metallopeptidase domain; Region: DUF2201_N; pfam13203 191026019485 VWA-like domain (DUF2201); Region: DUF2201; pfam09967 191026019486 Predicted membrane protein [Function unknown]; Region: COG1971 191026019487 Domain of unknown function DUF; Region: DUF204; pfam02659 191026019488 Domain of unknown function DUF; Region: DUF204; pfam02659 191026019489 Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG0429 191026019490 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086 191026019491 putative binding surface; other site 191026019492 active site 191026019493 Cache domain; Region: Cache_2; cl07034 191026019494 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 191026019495 dimerization interface [polypeptide binding]; other site 191026019496 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 191026019497 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 191026019498 dimer interface [polypeptide binding]; other site 191026019499 putative CheW interface [polypeptide binding]; other site 191026019500 Stress responsive A/B Barrel Domain; Region: Dabb; smart00886 191026019501 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 191026019502 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 191026019503 dimerization interface [polypeptide binding]; other site 191026019504 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 191026019505 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 191026019506 dimer interface [polypeptide binding]; other site 191026019507 putative CheW interface [polypeptide binding]; other site 191026019508 Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139 191026019509 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 191026019510 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 191026019511 Cysteine-rich domain; Region: CCG; pfam02754 191026019512 Cysteine-rich domain; Region: CCG; pfam02754 191026019513 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 191026019514 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 191026019515 propionate/acetate kinase; Provisional; Region: PRK12379 191026019516 phosphate acetyltransferase; Reviewed; Region: PRK05632 191026019517 Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132 191026019518 DRTGG domain; Region: DRTGG; pfam07085 191026019519 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 191026019520 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 191026019521 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 191026019522 Cysteine-rich domain; Region: CCG; pfam02754 191026019523 Cysteine-rich domain; Region: CCG; pfam02754 191026019524 FAD binding domain; Region: FAD_binding_4; pfam01565 191026019525 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 191026019526 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 191026019527 L-lactate permease; Region: Lactate_perm; cl00701 191026019528 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 191026019529 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 191026019530 dimer interface [polypeptide binding]; other site 191026019531 PYR/PP interface [polypeptide binding]; other site 191026019532 TPP binding site [chemical binding]; other site 191026019533 substrate binding site [chemical binding]; other site 191026019534 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 191026019535 Domain of unknown function; Region: EKR; smart00890 191026019536 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 191026019537 Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377 191026019538 TPP-binding site [chemical binding]; other site 191026019539 dimer interface [polypeptide binding]; other site 191026019540 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 191026019541 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 191026019542 active site 191026019543 phosphorylation site [posttranslational modification] 191026019544 intermolecular recognition site; other site 191026019545 dimerization interface [polypeptide binding]; other site 191026019546 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 191026019547 Walker A motif; other site 191026019548 ATP binding site [chemical binding]; other site 191026019549 Walker B motif; other site 191026019550 arginine finger; other site 191026019551 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 191026019552 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 191026019553 dimer interface [polypeptide binding]; other site 191026019554 phosphorylation site [posttranslational modification] 191026019555 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 191026019556 ATP binding site [chemical binding]; other site 191026019557 Mg2+ binding site [ion binding]; other site 191026019558 G-X-G motif; other site 191026019559 Response regulator receiver domain; Region: Response_reg; pfam00072 191026019560 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 191026019561 active site 191026019562 phosphorylation site [posttranslational modification] 191026019563 intermolecular recognition site; other site 191026019564 dimerization interface [polypeptide binding]; other site 191026019565 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4246 191026019566 Esterase-like activity of phytase; Region: Phytase-like; pfam13449 191026019567 PAS fold; Region: PAS_4; pfam08448 191026019568 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 191026019569 putative active site [active] 191026019570 heme pocket [chemical binding]; other site 191026019571 PAS domain S-box; Region: sensory_box; TIGR00229 191026019572 PAS domain; Region: PAS_8; pfam13188 191026019573 putative active site [active] 191026019574 heme pocket [chemical binding]; other site 191026019575 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 191026019576 Histidine kinase; Region: HisKA_2; pfam07568 191026019577 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 191026019578 ATP binding site [chemical binding]; other site 191026019579 Mg2+ binding site [ion binding]; other site 191026019580 G-X-G motif; other site 191026019581 Protein of unknown function (DUF3568); Region: DUF3568; pfam12092 191026019582 Response regulator receiver domain; Region: Response_reg; pfam00072 191026019583 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 191026019584 active site 191026019585 phosphorylation site [posttranslational modification] 191026019586 intermolecular recognition site; other site 191026019587 dimerization interface [polypeptide binding]; other site 191026019588 coenzyme A disulfide reductase; Reviewed; Region: PRK09564 191026019589 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 191026019590 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 191026019591 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 191026019592 active site residue [active] 191026019593 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 191026019594 trimer interface [polypeptide binding]; other site 191026019595 dimer interface [polypeptide binding]; other site 191026019596 putative active site [active] 191026019597 chaperone protein DnaJ; Provisional; Region: PRK14301 191026019598 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 191026019599 HSP70 interaction site [polypeptide binding]; other site 191026019600 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 191026019601 substrate binding site [polypeptide binding]; other site 191026019602 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 191026019603 Zn binding sites [ion binding]; other site 191026019604 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 191026019605 dimer interface [polypeptide binding]; other site 191026019606 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 191026019607 Domain of unknown function (DUF4340); Region: DUF4340; pfam14238 191026019608 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 191026019609 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 191026019610 Ligand Binding Site [chemical binding]; other site 191026019611 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 191026019612 Peptidase family M23; Region: Peptidase_M23; pfam01551 191026019613 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 191026019614 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 191026019615 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 191026019616 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 191026019617 FHIPEP family; Region: FHIPEP; pfam00771 191026019618 flagellar biosynthetic protein FlhF; Region: FlhF; TIGR03499 191026019619 SRP54-type protein, GTPase domain; Region: SRP54; smart00962 191026019620 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 191026019621 FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038 191026019622 P-loop; other site 191026019623 RNA polymerase sigma factor, FliA/WhiG family; Region: FliA_WhiG; TIGR02479 191026019624 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 191026019625 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 191026019626 DNA binding residues [nucleotide binding] 191026019627 chemotaxis regulatory protein CheY; Provisional; Region: PRK10610 191026019628 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 191026019629 active site 191026019630 phosphorylation site [posttranslational modification] 191026019631 intermolecular recognition site; other site 191026019632 dimerization interface [polypeptide binding]; other site 191026019633 Flagellar basal body-associated protein FliL; Region: FliL; pfam03748 191026019634 K+-transporting ATPase, c chain; Region: KdpC; cl00944 191026019635 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 191026019636 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 191026019637 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 191026019638 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 191026019639 dimer interface [polypeptide binding]; other site 191026019640 putative CheW interface [polypeptide binding]; other site 191026019641 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 191026019642 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 191026019643 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 191026019644 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 191026019645 S-adenosylmethionine binding site [chemical binding]; other site 191026019646 peptide chain release factor 1; Validated; Region: prfA; PRK00591 191026019647 This domain is found in peptide chain release factors; Region: PCRF; smart00937 191026019648 RF-1 domain; Region: RF-1; pfam00472 191026019649 Protein of unknown function (DUF1385); Region: DUF1385; pfam07136 191026019650 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 191026019651 Dissimilatory sulfite reductase (desulfoviridin), gamma subunit [Inorganic ion transport and metabolism]; Region: DsrC; COG2920 191026019652 DsrC like protein; Region: DsrC; pfam04358 191026019653 putative methanogenesis marker protein 1; Region: methan_mark_1; TIGR03266 191026019654 YcaO-like family; Region: YcaO; pfam02624 191026019655 TPR repeat; Region: TPR_11; pfam13414 191026019656 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 191026019657 TPR motif; other site 191026019658 binding surface 191026019659 TPR repeat; Region: TPR_11; pfam13414 191026019660 RNA polymerase-binding protein DksA; Region: dksA; TIGR02420 191026019661 Predicted RNA-binding protein homologous to eukaryotic snRNP [Transcription]; Region: COG1293 191026019662 Domain of unknown function (DUF814); Region: DUF814; pfam05670 191026019663 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 191026019664 TPR motif; other site 191026019665 binding surface 191026019666 TPR repeat; Region: TPR_11; pfam13414 191026019667 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cl00399 191026019668 MoaE homodimer interface [polypeptide binding]; other site 191026019669 MoaD interaction [polypeptide binding]; other site 191026019670 active site residues [active] 191026019671 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 191026019672 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 191026019673 active site 191026019674 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 191026019675 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 191026019676 Methyltransferase domain; Region: Methyltransf_31; pfam13847 191026019677 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 191026019678 S-adenosylmethionine binding site [chemical binding]; other site 191026019679 Transglycosylase SLT domain; Region: SLT_2; pfam13406 191026019680 murein hydrolase B; Provisional; Region: PRK10760; cl17906 191026019681 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 191026019682 N-acetyl-D-glucosamine binding site [chemical binding]; other site 191026019683 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 191026019684 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 191026019685 MPT binding site; other site 191026019686 trimer interface [polypeptide binding]; other site 191026019687 Protein of unknown function (DUF1614); Region: DUF1614; pfam07758 191026019688 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 191026019689 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 191026019690 substrate binding site; other site 191026019691 tetramer interface; other site 191026019692 PilZ domain; Region: PilZ; pfam07238 191026019693 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 191026019694 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_4; cd12162 191026019695 putative ligand binding site [chemical binding]; other site 191026019696 putative NAD binding site [chemical binding]; other site 191026019697 catalytic site [active] 191026019698 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 191026019699 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 191026019700 active site 191026019701 phosphorylation site [posttranslational modification] 191026019702 intermolecular recognition site; other site 191026019703 dimerization interface [polypeptide binding]; other site 191026019704 Putative exonuclease, RdgC; Region: RdgC; cl01122 191026019705 Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822 191026019706 active site 191026019707 catalytic triad [active] 191026019708 oxyanion hole [active] 191026019709 switch loop; other site 191026019710 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 191026019711 active site 191026019712 nucleophile elbow; other site 191026019713 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 191026019714 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 191026019715 putative efflux pump membrane fusion protein; Provisional; Region: PRK03598 191026019716 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 191026019717 HlyD family secretion protein; Region: HlyD_3; pfam13437 191026019718 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 191026019719 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 191026019720 Walker A/P-loop; other site 191026019721 ATP binding site [chemical binding]; other site 191026019722 Q-loop/lid; other site 191026019723 ABC transporter signature motif; other site 191026019724 Walker B; other site 191026019725 D-loop; other site 191026019726 H-loop/switch region; other site 191026019727 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 191026019728 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 191026019729 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 191026019730 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 191026019731 Domain of unknown function (DUF4198); Region: DUF4198; pfam10670 191026019732 MG2 domain; Region: A2M_N; pfam01835 191026019733 hypothetical protein; Region: PHA00670 191026019734 Bacteriophage head to tail connecting protein; Region: Head-tail_con; pfam12236 191026019735 Phage-related terminase [General function prediction only]; Region: COG5362; cl02216 191026019736 Protein of unknown function (DUF3154); Region: DUF3154; pfam11351 191026019737 Uncharacterized conserved protein [Function unknown]; Region: COG0398 191026019738 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 191026019739 YcaO-like family; Region: YcaO; pfam02624 191026019740 Fic family protein [Function unknown]; Region: COG3177 191026019741 Fic/DOC family; Region: Fic; pfam02661 191026019742 hypothetical protein; Provisional; Region: PRK09936 191026019743 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 191026019744 binding surface 191026019745 TPR motif; other site 191026019746 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 191026019747 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 191026019748 binding surface 191026019749 TPR motif; other site 191026019750 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 191026019751 binding surface 191026019752 TPR motif; other site 191026019753 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 191026019754 binding surface 191026019755 TPR motif; other site 191026019756 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 191026019757 binding surface 191026019758 TPR motif; other site 191026019759 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 191026019760 binding surface 191026019761 TPR motif; other site 191026019762 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 191026019763 binding surface 191026019764 TPR motif; other site 191026019765 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 191026019766 binding surface 191026019767 TPR motif; other site 191026019768 Bacteriophage N adsorption protein A C-term; Region: NfrA_C; pfam13283 191026019769 bacteriophage N4 adsorption protein B; Provisional; Region: nfrB; PRK11234 191026019770 active site 191026019771 Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632 191026019772 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 191026019773 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 191026019774 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 191026019775 active site 191026019776 homodimer interface [polypeptide binding]; other site 191026019777 PAS domain S-box; Region: sensory_box; TIGR00229 191026019778 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 191026019779 putative active site [active] 191026019780 heme pocket [chemical binding]; other site 191026019781 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 191026019782 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 191026019783 dimer interface [polypeptide binding]; other site 191026019784 phosphorylation site [posttranslational modification] 191026019785 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 191026019786 ATP binding site [chemical binding]; other site 191026019787 Mg2+ binding site [ion binding]; other site 191026019788 G-X-G motif; other site 191026019789 Iron-containing alcohol dehydrogenases-like; Region: Fe-ADH4; cd08188 191026019790 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 191026019791 putative active site [active] 191026019792 metal binding site [ion binding]; metal-binding site 191026019793 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 191026019794 Cache domain; Region: Cache_1; pfam02743 191026019795 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 191026019796 dimerization interface [polypeptide binding]; other site 191026019797 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 191026019798 PAS domain; Region: PAS_9; pfam13426 191026019799 putative active site [active] 191026019800 heme pocket [chemical binding]; other site 191026019801 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 191026019802 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 191026019803 metal binding site [ion binding]; metal-binding site 191026019804 active site 191026019805 I-site; other site 191026019806 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 191026019807 [FeFe] hydrogenase H-cluster maturation GTPase HydF; Region: GTP_HydF; TIGR03918 191026019808 E. coli Ras-like protein (Era)-like GTPase; Region: Era_like; cd00880 191026019809 G1 box; other site 191026019810 GTP/Mg2+ binding site [chemical binding]; other site 191026019811 Switch I region; other site 191026019812 G2 box; other site 191026019813 Switch II region; other site 191026019814 G3 box; other site 191026019815 G4 box; other site 191026019816 G5 box; other site 191026019817 biotin synthase; Provisional; Region: PRK07094 191026019818 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 191026019819 FeS/SAM binding site; other site 191026019820 Biotin and Thiamin Synthesis associated domain; Region: BATS; cl06149 191026019821 thiamine biosynthesis protein ThiH; Reviewed; Region: thiH; PRK09613 191026019822 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 191026019823 FeS/SAM binding site; other site 191026019824 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 191026019825 putative iron-only hydrogenase system regulator; Region: hyd_TM1266; TIGR03959 191026019826 Iron hydrogenase small subunit; Region: Fe_hyd_SSU; smart00902 191026019827 4Fe-4S binding domain; Region: Fer4_6; pfam12837 191026019828 Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906 191026019829 Domain of unknown function (DUF4301); Region: DUF4301; pfam14134 191026019830 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958 191026019831 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 191026019832 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 191026019833 homodimer interface [polypeptide binding]; other site 191026019834 substrate-cofactor binding pocket; other site 191026019835 pyridoxal 5'-phosphate binding site [chemical binding]; other site 191026019836 catalytic residue [active] 191026019837 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 191026019838 L-Ala-D/L-Glu epimerase; Provisional; Region: PRK15129 191026019839 active site 191026019840 Protein of unknown function (DUF1611); Region: DUF1611; pfam07755 191026019841 FeoA domain; Region: FeoA; pfam04023 191026019842 ferrous iron transport protein B; Reviewed; Region: feoB; PRK09554 191026019843 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 191026019844 G1 box; other site 191026019845 GTP/Mg2+ binding site [chemical binding]; other site 191026019846 Switch I region; other site 191026019847 G2 box; other site 191026019848 G3 box; other site 191026019849 Switch II region; other site 191026019850 G4 box; other site 191026019851 G5 box; other site 191026019852 Nucleoside recognition; Region: Gate; pfam07670 191026019853 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 191026019854 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 191026019855 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 191026019856 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 191026019857 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 191026019858 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12668 191026019859 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 191026019860 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK08375 191026019861 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 191026019862 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492 191026019863 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 191026019864 NADH-quinone oxidoreductase, chain I; Region: NuoI; TIGR01971 191026019865 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 191026019866 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 191026019867 NADH dehydrogenase subunit D; Validated; Region: PRK06075 191026019868 NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649 191026019869 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; pfam00329 191026019870 NADH dehydrogenase subunit B; Validated; Region: PRK06411 191026019871 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535 191026019872 response regulator PleD; Reviewed; Region: pleD; PRK09581 191026019873 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 191026019874 active site 191026019875 phosphorylation site [posttranslational modification] 191026019876 intermolecular recognition site; other site 191026019877 dimerization interface [polypeptide binding]; other site 191026019878 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 191026019879 putative active site [active] 191026019880 heme pocket [chemical binding]; other site 191026019881 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 191026019882 metal binding site [ion binding]; metal-binding site 191026019883 active site 191026019884 I-site; other site 191026019885 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 191026019886 UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs; Region: UGD_SDR_e; cd05230 191026019887 NAD binding site [chemical binding]; other site 191026019888 putative substrate binding site 2 [chemical binding]; other site 191026019889 putative substrate binding site 1 [chemical binding]; other site 191026019890 active site 191026019891 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 191026019892 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 191026019893 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 191026019894 Coenzyme A binding pocket [chemical binding]; other site 191026019895 OsmC-like protein; Region: OsmC; pfam02566 191026019896 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 191026019897 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 191026019898 Bacterial Ig-like domain (group 1); Region: Big_1; cl17740 191026019899 Transglutaminase-like superfamily; Region: Transglut_core; cl17362 191026019900 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 191026019901 PAS domain; Region: PAS_9; pfam13426 191026019902 putative active site [active] 191026019903 heme pocket [chemical binding]; other site 191026019904 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 191026019905 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 191026019906 PAS domain S-box; Region: sensory_box; TIGR00229 191026019907 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 191026019908 putative active site [active] 191026019909 heme pocket [chemical binding]; other site 191026019910 PAS domain S-box; Region: sensory_box; TIGR00229 191026019911 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 191026019912 putative active site [active] 191026019913 heme pocket [chemical binding]; other site 191026019914 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 191026019915 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 191026019916 metal binding site [ion binding]; metal-binding site 191026019917 active site 191026019918 I-site; other site 191026019919 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 191026019920 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 191026019921 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 191026019922 putative valine binding site [chemical binding]; other site 191026019923 dimer interface [polypeptide binding]; other site 191026019924 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 191026019925 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl17212 191026019926 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 191026019927 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 191026019928 substrate binding pocket [chemical binding]; other site 191026019929 membrane-bound complex binding site; other site 191026019930 hinge residues; other site 191026019931 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 191026019932 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 191026019933 substrate binding pocket [chemical binding]; other site 191026019934 membrane-bound complex binding site; other site 191026019935 hinge residues; other site 191026019936 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964 191026019937 YheO-like PAS domain; Region: PAS_6; pfam08348 191026019938 HTH domain; Region: HTH_22; pfam13309 191026019939 leucine transcriptional activator; Reviewed; Region: leuO; PRK09508 191026019940 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 191026019941 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 191026019942 substrate binding pocket [chemical binding]; other site 191026019943 dimerization interface [polypeptide binding]; other site 191026019944 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 191026019945 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 191026019946 dimer interface [polypeptide binding]; other site 191026019947 putative CheW interface [polypeptide binding]; other site 191026019948 Hemerythrin; Region: Hemerythrin; cd12107 191026019949 Fe binding site [ion binding]; other site 191026019950 Transcriptional regulators [Transcription]; Region: FadR; COG2186 191026019951 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 191026019952 DNA-binding site [nucleotide binding]; DNA binding site 191026019953 FCD domain; Region: FCD; pfam07729 191026019954 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 191026019955 Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809 191026019956 active site 191026019957 substrate binding site [chemical binding]; other site 191026019958 FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070 191026019959 FMN binding site [chemical binding]; other site 191026019960 putative catalytic residues [active] 191026019961 DNA polymerase III, delta subunit; Region: DNA_pol3_delta2; pfam13177 191026019962 DNA polymerase III subunit delta'; Validated; Region: PRK08485 191026019963 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 191026019964 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 191026019965 GDP-binding site [chemical binding]; other site 191026019966 ACT binding site; other site 191026019967 IMP binding site; other site 191026019968 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 191026019969 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 191026019970 N-acetyl-D-glucosamine binding site [chemical binding]; other site 191026019971 catalytic residue [active] 191026019972 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 191026019973 RNB domain; Region: RNB; pfam00773 191026019974 Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; cl00410 191026019975 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 191026019976 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 191026019977 active site 191026019978 phosphorylation site [posttranslational modification] 191026019979 intermolecular recognition site; other site 191026019980 Domain of unknown function (DUF3369); Region: DUF3369; pfam11849 191026019981 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 191026019982 Zn2+ binding site [ion binding]; other site 191026019983 Mg2+ binding site [ion binding]; other site 191026019984 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 191026019985 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 191026019986 active site 191026019987 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 191026019988 phosphorylation site [posttranslational modification] 191026019989 intermolecular recognition site; other site 191026019990 Domain of unknown function (DUF3369); Region: DUF3369; pfam11849 191026019991 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 191026019992 dimer interface [polypeptide binding]; other site 191026019993 phosphorylation site [posttranslational modification] 191026019994 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 191026019995 ATP binding site [chemical binding]; other site 191026019996 Mg2+ binding site [ion binding]; other site 191026019997 G-X-G motif; other site 191026019998 FOG: CBS domain [General function prediction only]; Region: COG0517 191026019999 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the acetoin utilization proteins in bacteria. Acetoin is a product of fermentative metabolism in many prokaryotic and eukaryotic microorganisms. They produce...; Region: CBS_pair_ACT_assoc; cd04584 191026020000 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 191026020001 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 191026020002 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 191026020003 S-adenosylmethionine binding site [chemical binding]; other site 191026020004 2-keto-3-deoxy-galactonokinase [Carbohydrate transport and metabolism]; Region: DgoK; COG3734 191026020005 8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958 191026020006 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 191026020007 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 191026020008 catalytic residue [active] 191026020009 SPRY domain; Region: SPRY; cl02614 191026020010 hypothetical protein; Region: PHA01733 191026020011 hypothetical protein; Region: PHA00661 191026020012 hypothetical protein; Region: PHA00662 191026020013 hypothetical protein; Region: PHA00664 191026020014 major capsid protein; Region: PHA00665 191026020015 putative protease; Region: PHA00666 191026020016 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 191026020017 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 191026020018 thiamine biosynthesis protein ThiC; Provisional; Region: PRK13352 191026020019 thiamine biosynthesis protein ThiC; Region: thiC; TIGR00190 191026020020 Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757 191026020021 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR_like; cd08242 191026020022 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 191026020023 putative NAD(P) binding site [chemical binding]; other site 191026020024 catalytic Zn binding site [ion binding]; other site 191026020025 structural Zn binding site [ion binding]; other site 191026020026 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 191026020027 Uncharacterized ArCR, COG2043; Region: DUF169; pfam02596 191026020028 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 191026020029 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 191026020030 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 191026020031 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 191026020032 putative active site [active] 191026020033 heme pocket [chemical binding]; other site 191026020034 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 191026020035 dimer interface [polypeptide binding]; other site 191026020036 phosphorylation site [posttranslational modification] 191026020037 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 191026020038 ATP binding site [chemical binding]; other site 191026020039 Mg2+ binding site [ion binding]; other site 191026020040 G-X-G motif; other site 191026020041 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 191026020042 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 191026020043 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 191026020044 binding surface 191026020045 TPR motif; other site 191026020046 Stage II sporulation protein; Region: SpoIID; pfam08486 191026020047 SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669 191026020048 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 191026020049 Interdomain contacts; other site 191026020050 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 191026020051 LPP20 lipoprotein; Region: LPP20; cl15824 191026020052 TPR repeat; Region: TPR_11; pfam13414 191026020053 S-layer homology domain; Region: SLH; pfam00395 191026020054 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 191026020055 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 191026020056 sodium/proton antiporter; Reviewed; Region: nhaB; PRK09547 191026020057 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 191026020058 acetyl coenzyme A synthetase (ADP forming), alpha domain; Region: AcCoA-syn-alpha; TIGR02717 191026020059 CoA binding domain; Region: CoA_binding_2; pfam13380 191026020060 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 191026020061 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 191026020062 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 191026020063 putative active site [active] 191026020064 heme pocket [chemical binding]; other site 191026020065 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 191026020066 putative active site [active] 191026020067 heme pocket [chemical binding]; other site 191026020068 PAS domain; Region: PAS; smart00091 191026020069 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 191026020070 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 191026020071 dimer interface [polypeptide binding]; other site 191026020072 phosphorylation site [posttranslational modification] 191026020073 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 191026020074 ATP binding site [chemical binding]; other site 191026020075 Mg2+ binding site [ion binding]; other site 191026020076 G-X-G motif; other site 191026020077 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 191026020078 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 191026020079 WHG domain; Region: WHG; pfam13305 191026020080 squalene-hopene cyclase; Region: hopene_cyclase; TIGR01507 191026020081 Squalene cyclase (SQCY) domain subgroup 1; found in class II terpene cyclases that have an alpha 6 - alpha 6 barrel fold. Squalene cyclase (SQCY) and 2,3-oxidosqualene cyclase (OSQCY) are integral membrane proteins that catalyze a cationic cyclization...; Region: SQCY_1; cd02892 191026020082 Active site cavity [active] 191026020083 catalytic acid [active] 191026020084 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 191026020085 Acyl-ACP thioesterase [Lipid metabolism]; Region: FatA; COG3884 191026020086 active site 2 [active] 191026020087 active site 1 [active] 191026020088 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 191026020089 active site 1 [active] 191026020090 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 191026020091 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 191026020092 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 191026020093 active site 191026020094 dimer interface [polypeptide binding]; other site 191026020095 motif 1; other site 191026020096 motif 2; other site 191026020097 motif 3; other site 191026020098 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 191026020099 anticodon binding site; other site 191026020100 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 191026020101 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 191026020102 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 191026020103 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 191026020104 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 191026020105 23S rRNA binding site [nucleotide binding]; other site 191026020106 L21 binding site [polypeptide binding]; other site 191026020107 L13 binding site [polypeptide binding]; other site 191026020108 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 191026020109 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 191026020110 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 191026020111 dimer interface [polypeptide binding]; other site 191026020112 motif 1; other site 191026020113 active site 191026020114 motif 2; other site 191026020115 motif 3; other site 191026020116 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 191026020117 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 191026020118 putative tRNA-binding site [nucleotide binding]; other site 191026020119 B3/4 domain; Region: B3_4; pfam03483 191026020120 tRNA synthetase B5 domain; Region: B5; smart00874 191026020121 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 191026020122 dimer interface [polypeptide binding]; other site 191026020123 motif 1; other site 191026020124 motif 3; other site 191026020125 motif 2; other site 191026020126 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 191026020127 DNA-binding transcriptional repressor AcrR; Provisional; Region: PRK10668 191026020128 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 191026020129 MAATS-type transcriptional repressor, C-terminal region; Region: TetR_C_2; pfam08361 191026020130 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 191026020131 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 191026020132 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 191026020133 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 191026020134 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 191026020135 binding surface 191026020136 TPR motif; other site 191026020137 TPR repeat; Region: TPR_11; pfam13414 191026020138 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 191026020139 binding surface 191026020140 TPR motif; other site 191026020141 Tetratricopeptide repeat; Region: TPR_12; pfam13424 191026020142 multidrug efflux protein; Reviewed; Region: PRK09579 191026020143 phosphoglucomutase; Validated; Region: PRK07564 191026020144 This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801 191026020145 active site 191026020146 substrate binding site [chemical binding]; other site 191026020147 metal binding site [ion binding]; metal-binding site 191026020148 Response regulator receiver domain; Region: Response_reg; pfam00072 191026020149 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 191026020150 active site 191026020151 phosphorylation site [posttranslational modification] 191026020152 intermolecular recognition site; other site 191026020153 dimerization interface [polypeptide binding]; other site 191026020154 PAS domain; Region: PAS; smart00091 191026020155 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 191026020156 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 191026020157 dimer interface [polypeptide binding]; other site 191026020158 phosphorylation site [posttranslational modification] 191026020159 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 191026020160 ATP binding site [chemical binding]; other site 191026020161 Mg2+ binding site [ion binding]; other site 191026020162 G-X-G motif; other site 191026020163 Response regulator receiver domain; Region: Response_reg; pfam00072 191026020164 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 191026020165 active site 191026020166 phosphorylation site [posttranslational modification] 191026020167 intermolecular recognition site; other site 191026020168 dimerization interface [polypeptide binding]; other site 191026020169 Hpt domain; Region: Hpt; pfam01627 191026020170 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 191026020171 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 191026020172 active site 191026020173 phosphorylation site [posttranslational modification] 191026020174 intermolecular recognition site; other site 191026020175 dimerization interface [polypeptide binding]; other site 191026020176 CheB methylesterase; Region: CheB_methylest; pfam01339 191026020177 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 191026020178 putative binding surface; other site 191026020179 active site 191026020180 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 191026020181 ATP binding site [chemical binding]; other site 191026020182 Mg2+ binding site [ion binding]; other site 191026020183 G-X-G motif; other site 191026020184 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 191026020185 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 191026020186 Response regulator receiver domain; Region: Response_reg; pfam00072 191026020187 active site 191026020188 phosphorylation site [posttranslational modification] 191026020189 intermolecular recognition site; other site 191026020190 dimerization interface [polypeptide binding]; other site 191026020191 CheW-like domain; Region: CheW; pfam01584 191026020192 Methyltransferase, chemotaxis proteins; Region: MeTrc; smart00138 191026020193 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 191026020194 TPR repeat; Region: TPR_11; pfam13414 191026020195 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 191026020196 binding surface 191026020197 TPR motif; other site 191026020198 Tetratricopeptide repeat; Region: TPR_16; pfam13432 191026020199 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 191026020200 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 191026020201 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 191026020202 N-acetyl-D-glucosamine binding site [chemical binding]; other site 191026020203 catalytic residue [active] 191026020204 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 191026020205 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 191026020206 metal binding site [ion binding]; metal-binding site 191026020207 active site 191026020208 I-site; other site 191026020209 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 191026020210 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 191026020211 TPR motif; other site 191026020212 binding surface 191026020213 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 191026020214 binding surface 191026020215 TPR motif; other site 191026020216 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 191026020217 TPR motif; other site 191026020218 binding surface 191026020219 pantoate--beta-alanine ligase; Region: panC; TIGR00018 191026020220 Pantoate-beta-alanine ligase; Region: PanC; cd00560 191026020221 active site 191026020222 ATP-binding site [chemical binding]; other site 191026020223 pantoate-binding site; other site 191026020224 HXXH motif; other site 191026020225 S-adenosylmethionine synthetase; Validated; Region: PRK05250 191026020226 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 191026020227 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 191026020228 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 191026020229 Short C-terminal domain; Region: SHOCT; pfam09851 191026020230 spore photoproduct lyase; Region: photo_TT_lyase; cl15393 191026020231 Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170 191026020232 elongation factor G; Reviewed; Region: PRK12740 191026020233 G1 box; other site 191026020234 putative GEF interaction site [polypeptide binding]; other site 191026020235 GTP/Mg2+ binding site [chemical binding]; other site 191026020236 Switch I region; other site 191026020237 G2 box; other site 191026020238 G3 box; other site 191026020239 Switch II region; other site 191026020240 G4 box; other site 191026020241 G5 box; other site 191026020242 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 191026020243 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 191026020244 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 191026020245 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 191026020246 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 191026020247 putative acyl-acceptor binding pocket; other site 191026020248 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 191026020249 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 191026020250 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 191026020251 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 191026020252 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 191026020253 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 191026020254 rRNA interaction site [nucleotide binding]; other site 191026020255 S8 interaction site; other site 191026020256 putative laminin-1 binding site; other site 191026020257 elongation factor Ts; Reviewed; Region: tsf; PRK12332 191026020258 UBA/TS-N domain; Region: UBA; pfam00627 191026020259 Elongation factor TS; Region: EF_TS; pfam00889 191026020260 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 191026020261 putative nucleotide binding site [chemical binding]; other site 191026020262 uridine monophosphate binding site [chemical binding]; other site 191026020263 homohexameric interface [polypeptide binding]; other site 191026020264 ribosome recycling factor; Reviewed; Region: frr; PRK00083 191026020265 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 191026020266 hinge region; other site 191026020267 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 191026020268 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 191026020269 catalytic residue [active] 191026020270 putative FPP diphosphate binding site; other site 191026020271 putative FPP binding hydrophobic cleft; other site 191026020272 dimer interface [polypeptide binding]; other site 191026020273 putative IPP diphosphate binding site; other site 191026020274 Bacterial SH3 domain; Region: SH3_3; pfam08239 191026020275 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 191026020276 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 191026020277 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 191026020278 Zn2+ binding site [ion binding]; other site 191026020279 Mg2+ binding site [ion binding]; other site 191026020280 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 191026020281 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 191026020282 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 191026020283 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 191026020284 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 191026020285 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 191026020286 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 191026020287 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 191026020288 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 191026020289 active site 191026020290 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 191026020291 protein binding site [polypeptide binding]; other site 191026020292 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 191026020293 putative substrate binding region [chemical binding]; other site 191026020294 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 191026020295 flagellin; Provisional; Region: PRK12804 191026020296 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 191026020297 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 191026020298 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 191026020299 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 191026020300 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 191026020301 Flagellin-specific chaperone FliS [Cell motility and secretion / Intracellular trafficking and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FliS; COG1516 191026020302 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 191026020303 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 191026020304 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 191026020305 active site 191026020306 zinc-ribbon domain; Region: zinc_ribbon_4; pfam13717 191026020307 Uncharacterized protein conserved in archaea [Function unknown]; Region: COG2881 191026020308 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 191026020309 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 191026020310 ligand binding site [chemical binding]; other site 191026020311 putative heme d1 biosynthesis radical SAM protein NirJ1; Region: rSAM_NirJ1; TIGR04054 191026020312 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 191026020313 FeS/SAM binding site; other site 191026020314 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 191026020315 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 191026020316 dimer interface [polypeptide binding]; other site 191026020317 active site 191026020318 Schiff base residues; other site 191026020319 putative heme d1 biosynthesis radical SAM protein NirJ2; Region: rSAM_NirJ2; TIGR04055 191026020320 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 191026020321 FeS/SAM binding site; other site 191026020322 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 191026020323 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 191026020324 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 191026020325 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 191026020326 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 191026020327 substrate binding site [chemical binding]; other site 191026020328 hexamer interface [polypeptide binding]; other site 191026020329 metal binding site [ion binding]; metal-binding site 191026020330 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399 191026020331 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 191026020332 PAS domain; Region: PAS_9; pfam13426 191026020333 putative active site [active] 191026020334 heme pocket [chemical binding]; other site 191026020335 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 191026020336 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 191026020337 metal binding site [ion binding]; metal-binding site 191026020338 active site 191026020339 I-site; other site 191026020340 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3009 191026020341 Protein of unknown function (DUF330); Region: DUF330; cl01135 191026020342 mce related protein; Region: MCE; pfam02470 191026020343 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 191026020344 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 191026020345 Walker A/P-loop; other site 191026020346 ATP binding site [chemical binding]; other site 191026020347 Q-loop/lid; other site 191026020348 ABC transporter signature motif; other site 191026020349 Walker B; other site 191026020350 D-loop; other site 191026020351 H-loop/switch region; other site 191026020352 STAS domain; Region: STAS_2; pfam13466 191026020353 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 191026020354 Permease; Region: Permease; pfam02405 191026020355 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 191026020356 dimer interface [polypeptide binding]; other site 191026020357 putative CheW interface [polypeptide binding]; other site 191026020358 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 191026020359 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 191026020360 dimer interface [polypeptide binding]; other site 191026020361 putative CheW interface [polypeptide binding]; other site 191026020362 Proline dehydrogenase; Region: Pro_dh; cl03282 191026020363 1-pyrroline-5-carboxylate dehydrogenase; Provisional; Region: PRK03137 191026020364 Delta(1)-pyrroline-5-carboxylate dehydrogenase, RocA; Region: ALDH_PutA-P5CDH-RocA; cd07124 191026020365 Glutamate binding site [chemical binding]; other site 191026020366 homodimer interface [polypeptide binding]; other site 191026020367 NAD binding site [chemical binding]; other site 191026020368 catalytic residues [active] 191026020369 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 191026020370 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 191026020371 putative DNA binding site [nucleotide binding]; other site 191026020372 putative Zn2+ binding site [ion binding]; other site 191026020373 AsnC family; Region: AsnC_trans_reg; pfam01037 191026020374 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 191026020375 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 191026020376 motif II; other site 191026020377 ribulose bisphosphate carboxylase; Provisional; Region: PRK13475 191026020378 Ribulose bisphosphate carboxylase large chain, Form II; Region: RuBisCO_large_II; cd08211 191026020379 dimer interface [polypeptide binding]; other site 191026020380 active site 191026020381 catalytic residue [active] 191026020382 metal binding site [ion binding]; metal-binding site 191026020383 phosphoribulokinase; Provisional; Region: PRK07429 191026020384 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 191026020385 active site 191026020386 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 191026020387 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 191026020388 putative active site [active] 191026020389 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 191026020390 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 191026020391 Walker A motif; other site 191026020392 ATP binding site [chemical binding]; other site 191026020393 Walker B motif; other site 191026020394 arginine finger; other site 191026020395 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 191026020396 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 191026020397 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 191026020398 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 191026020399 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 191026020400 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 191026020401 substrate binding site [chemical binding]; other site 191026020402 hexamer interface [polypeptide binding]; other site 191026020403 metal binding site [ion binding]; metal-binding site 191026020404 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 191026020405 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 191026020406 intersubunit interface [polypeptide binding]; other site 191026020407 active site 191026020408 zinc binding site [ion binding]; other site 191026020409 Na+ binding site [ion binding]; other site 191026020410 phosphoglycerate kinase; Provisional; Region: pgk; PRK00073 191026020411 Phosphoglycerate kinase; Region: PGK; pfam00162 191026020412 substrate binding site [chemical binding]; other site 191026020413 hinge regions; other site 191026020414 ADP binding site [chemical binding]; other site 191026020415 catalytic site [active] 191026020416 transketolase; Reviewed; Region: PRK12753 191026020417 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 191026020418 TPP-binding site [chemical binding]; other site 191026020419 dimer interface [polypeptide binding]; other site 191026020420 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 191026020421 PYR/PP interface [polypeptide binding]; other site 191026020422 dimer interface [polypeptide binding]; other site 191026020423 TPP binding site [chemical binding]; other site 191026020424 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 191026020425 EamA-like transporter family; Region: EamA; pfam00892 191026020426 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 191026020427 EamA-like transporter family; Region: EamA; pfam00892 191026020428 Protein of unknown function (DUF615); Region: DUF615; pfam04751 191026020429 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 191026020430 EamA-like transporter family; Region: EamA; pfam00892 191026020431 EamA-like transporter family; Region: EamA; pfam00892 191026020432 Menaquinone biosynthesis; Region: VitK2_biosynth; cl17475 191026020433 putative menaquinone biosynthesis protein, SCO4494 family; Region: mena_SCO4494; TIGR03700 191026020434 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377 191026020435 FeS/SAM binding site; other site 191026020436 menaquinone biosynthesis protein, SCO4550 family; Region: mena_SCO4550; TIGR03699 191026020437 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 191026020438 FeS/SAM binding site; other site 191026020439 Menaquinone biosynthesis; Region: VitK2_biosynth; pfam02621 191026020440 Transcriptional regulator [Transcription]; Region: LysR; COG0583 191026020441 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 191026020442 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 191026020443 putative dimerization interface [polypeptide binding]; other site 191026020444 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 191026020445 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 191026020446 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 191026020447 alphaNTD - beta interaction site [polypeptide binding]; other site 191026020448 alphaNTD homodimer interface [polypeptide binding]; other site 191026020449 alphaNTD - beta' interaction site [polypeptide binding]; other site 191026020450 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 191026020451 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 191026020452 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 191026020453 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 191026020454 RNA binding surface [nucleotide binding]; other site 191026020455 30S ribosomal protein S11; Validated; Region: PRK05309 191026020456 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 191026020457 30S ribosomal protein S13; Region: bact_S13; TIGR03631 191026020458 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 191026020459 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 191026020460 active site 191026020461 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 191026020462 SecY translocase; Region: SecY; pfam00344 191026020463 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 191026020464 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 191026020465 23S rRNA binding site [nucleotide binding]; other site 191026020466 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 191026020467 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 191026020468 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 191026020469 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 191026020470 5S rRNA interface [nucleotide binding]; other site 191026020471 L27 interface [polypeptide binding]; other site 191026020472 23S rRNA interface [nucleotide binding]; other site 191026020473 L5 interface [polypeptide binding]; other site 191026020474 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 191026020475 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 191026020476 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 191026020477 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 191026020478 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 191026020479 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 191026020480 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 191026020481 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 191026020482 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 191026020483 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 191026020484 RNA binding site [nucleotide binding]; other site 191026020485 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 191026020486 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 191026020487 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 191026020488 23S rRNA interface [nucleotide binding]; other site 191026020489 putative translocon interaction site; other site 191026020490 signal recognition particle (SRP54) interaction site; other site 191026020491 L23 interface [polypeptide binding]; other site 191026020492 trigger factor interaction site; other site 191026020493 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 191026020494 23S rRNA interface [nucleotide binding]; other site 191026020495 5S rRNA interface [nucleotide binding]; other site 191026020496 putative antibiotic binding site [chemical binding]; other site 191026020497 L25 interface [polypeptide binding]; other site 191026020498 L27 interface [polypeptide binding]; other site 191026020499 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 191026020500 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 191026020501 G-X-X-G motif; other site 191026020502 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 191026020503 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 191026020504 putative translocon binding site; other site 191026020505 protein-rRNA interface [nucleotide binding]; other site 191026020506 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 191026020507 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 191026020508 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 191026020509 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 191026020510 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 191026020511 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 191026020512 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 191026020513 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 191026020514 elongation factor G; Reviewed; Region: PRK00007 191026020515 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 191026020516 G1 box; other site 191026020517 putative GEF interaction site [polypeptide binding]; other site 191026020518 GTP/Mg2+ binding site [chemical binding]; other site 191026020519 Switch I region; other site 191026020520 G2 box; other site 191026020521 G3 box; other site 191026020522 Switch II region; other site 191026020523 G4 box; other site 191026020524 G5 box; other site 191026020525 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 191026020526 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 191026020527 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 191026020528 30S ribosomal protein S7; Validated; Region: PRK05302 191026020529 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 191026020530 S17 interaction site [polypeptide binding]; other site 191026020531 S8 interaction site; other site 191026020532 16S rRNA interaction site [nucleotide binding]; other site 191026020533 streptomycin interaction site [chemical binding]; other site 191026020534 23S rRNA interaction site [nucleotide binding]; other site 191026020535 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 191026020536 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 191026020537 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 191026020538 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 191026020539 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 191026020540 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 191026020541 RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998 191026020542 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 191026020543 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 191026020544 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 191026020545 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 191026020546 DNA binding site [nucleotide binding] 191026020547 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 191026020548 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 191026020549 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 191026020550 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 191026020551 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 191026020552 RPB11 interaction site [polypeptide binding]; other site 191026020553 RPB12 interaction site [polypeptide binding]; other site 191026020554 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 191026020555 RPB3 interaction site [polypeptide binding]; other site 191026020556 RPB1 interaction site [polypeptide binding]; other site 191026020557 RPB11 interaction site [polypeptide binding]; other site 191026020558 RPB10 interaction site [polypeptide binding]; other site 191026020559 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 191026020560 core dimer interface [polypeptide binding]; other site 191026020561 peripheral dimer interface [polypeptide binding]; other site 191026020562 L10 interface [polypeptide binding]; other site 191026020563 L11 interface [polypeptide binding]; other site 191026020564 putative EF-Tu interaction site [polypeptide binding]; other site 191026020565 putative EF-G interaction site [polypeptide binding]; other site 191026020566 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 191026020567 23S rRNA interface [nucleotide binding]; other site 191026020568 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 191026020569 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 191026020570 mRNA/rRNA interface [nucleotide binding]; other site 191026020571 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 191026020572 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 191026020573 23S rRNA interface [nucleotide binding]; other site 191026020574 L7/L12 interface [polypeptide binding]; other site 191026020575 putative thiostrepton binding site; other site 191026020576 L25 interface [polypeptide binding]; other site 191026020577 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 191026020578 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 191026020579 putative homodimer interface [polypeptide binding]; other site 191026020580 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 191026020581 heterodimer interface [polypeptide binding]; other site 191026020582 homodimer interface [polypeptide binding]; other site 191026020583 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK05740 191026020584 elongation factor Tu; Reviewed; Region: PRK00049 191026020585 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 191026020586 G1 box; other site 191026020587 GEF interaction site [polypeptide binding]; other site 191026020588 GTP/Mg2+ binding site [chemical binding]; other site 191026020589 Switch I region; other site 191026020590 G2 box; other site 191026020591 G3 box; other site 191026020592 Switch II region; other site 191026020593 G4 box; other site 191026020594 G5 box; other site 191026020595 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 191026020596 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 191026020597 Antibiotic Binding Site [chemical binding]; other site 191026020598 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 191026020599 tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042 191026020600 FMN binding site [chemical binding]; other site 191026020601 active site 191026020602 catalytic residues [active] 191026020603 substrate binding site [chemical binding]; other site 191026020604 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 191026020605 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 191026020606 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 191026020607 active site 191026020608 phosphorylation site [posttranslational modification] 191026020609 intermolecular recognition site; other site 191026020610 dimerization interface [polypeptide binding]; other site 191026020611 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 191026020612 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 191026020613 Cl- selectivity filter; other site 191026020614 Cl- binding residues [ion binding]; other site 191026020615 pore gating glutamate residue; other site 191026020616 dimer interface [polypeptide binding]; other site 191026020617 FOG: CBS domain [General function prediction only]; Region: COG0517 191026020618 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with either the SpoIVFB domain (sporulation protein, stage IV cell wall formation, F locus, promoter-distal B) or the chloride channel protein EriC; Region: CBS_pair_SpoIVFB_EriC_assoc2; cd04613 191026020619 HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis. HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197 191026020620 dimerization interface [polypeptide binding]; other site 191026020621 hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124 191026020622 ATP binding site [chemical binding]; other site 191026020623 hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062 191026020624 hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075 191026020625 Response regulator receiver domain; Region: Response_reg; pfam00072 191026020626 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 191026020627 active site 191026020628 phosphorylation site [posttranslational modification] 191026020629 intermolecular recognition site; other site 191026020630 dimerization interface [polypeptide binding]; other site 191026020631 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 191026020632 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 191026020633 active site 191026020634 phosphorylation site [posttranslational modification] 191026020635 intermolecular recognition site; other site 191026020636 dimerization interface [polypeptide binding]; other site 191026020637 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 191026020638 DNA-binding site [nucleotide binding]; DNA binding site 191026020639 RNA-binding motif; other site 191026020640 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 191026020641 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 191026020642 HflX GTPase family; Region: HflX; cd01878 191026020643 G1 box; other site 191026020644 GTP/Mg2+ binding site [chemical binding]; other site 191026020645 Switch I region; other site 191026020646 G2 box; other site 191026020647 G3 box; other site 191026020648 Switch II region; other site 191026020649 G4 box; other site 191026020650 G5 box; other site 191026020651 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 191026020652 purine monophosphate binding site [chemical binding]; other site 191026020653 dimer interface [polypeptide binding]; other site 191026020654 putative catalytic residues [active] 191026020655 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 191026020656 binding surface 191026020657 TPR motif; other site 191026020658 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 191026020659 binding surface 191026020660 TPR motif; other site 191026020661 flagellar basal body rod protein FlgB; Provisional; Region: flgB; PRK12621 191026020662 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182 191026020663 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 191026020664 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 191026020665 Flagellar hook-basal body complex protein FliE; Region: FliE; pfam02049 191026020666 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 191026020667 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 191026020668 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 191026020669 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 191026020670 MgtE intracellular N domain; Region: MgtE_N; cl15244 191026020671 FliG C-terminal domain; Region: FliG_C; pfam01706 191026020672 Flagellar assembly protein FliH; Region: FliH; pfam02108 191026020673 flagellar protein export ATPase FliI; Region: FliI_clade1; TIGR03496 191026020674 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 191026020675 Walker A motif/ATP binding site; other site 191026020676 Walker B motif; other site 191026020677 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 191026020678 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 191026020679 substrate binding pocket [chemical binding]; other site 191026020680 membrane-bound complex binding site; other site 191026020681 hinge residues; other site 191026020682 Response regulator receiver domain; Region: Response_reg; pfam00072 191026020683 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 191026020684 active site 191026020685 phosphorylation site [posttranslational modification] 191026020686 intermolecular recognition site; other site 191026020687 dimerization interface [polypeptide binding]; other site 191026020688 Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331 191026020689 hypothetical protein; Provisional; Region: PRK08328 191026020690 Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cl17196 191026020691 ATP binding site [chemical binding]; other site 191026020692 substrate interface [chemical binding]; other site 191026020693 ThiS family; Region: ThiS; pfam02597 191026020694 charged pocket; other site 191026020695 hydrophobic patch; other site 191026020696 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 191026020697 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 191026020698 putative molybdenum transport ATP-binding protein ModF; Provisional; Region: PRK10938 191026020699 Walker A/P-loop; other site 191026020700 ATP binding site [chemical binding]; other site 191026020701 ABC transporter signature motif; other site 191026020702 Walker B; other site 191026020703 D-loop; other site 191026020704 H-loop/switch region; other site 191026020705 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 191026020706 Walker A/P-loop; other site 191026020707 ATP binding site [chemical binding]; other site 191026020708 Q-loop/lid; other site 191026020709 ABC transporter signature motif; other site 191026020710 Walker B; other site 191026020711 D-loop; other site 191026020712 H-loop/switch region; other site 191026020713 Uncharacterized conserved protein [Function unknown]; Region: COG2006 191026020714 Domain of unknown function (DUF362); Region: DUF362; pfam04015 191026020715 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068 191026020716 Acylphosphatase; Region: Acylphosphatase; pfam00708 191026020717 HypF finger; Region: zf-HYPF; pfam07503 191026020718 HypF finger; Region: zf-HYPF; pfam07503 191026020719 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 191026020720 Response regulator receiver domain; Region: Response_reg; pfam00072 191026020721 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 191026020722 active site 191026020723 phosphorylation site [posttranslational modification] 191026020724 intermolecular recognition site; other site 191026020725 dimerization interface [polypeptide binding]; other site 191026020726 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 191026020727 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 191026020728 dimer interface [polypeptide binding]; other site 191026020729 phosphorylation site [posttranslational modification] 191026020730 Response regulator receiver domain; Region: Response_reg; pfam00072 191026020731 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 191026020732 active site 191026020733 phosphorylation site [posttranslational modification] 191026020734 intermolecular recognition site; other site 191026020735 dimerization interface [polypeptide binding]; other site 191026020736 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 191026020737 dimer interface [polypeptide binding]; other site 191026020738 phosphorylation site [posttranslational modification] 191026020739 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 191026020740 ATP binding site [chemical binding]; other site 191026020741 Mg2+ binding site [ion binding]; other site 191026020742 G-X-G motif; other site 191026020743 Cytidylate kinase-like family; Region: Cytidylate_kin2; pfam13189 191026020744 Response regulator receiver domain; Region: Response_reg; pfam00072 191026020745 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 191026020746 active site 191026020747 phosphorylation site [posttranslational modification] 191026020748 intermolecular recognition site; other site 191026020749 dimerization interface [polypeptide binding]; other site 191026020750 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 191026020751 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 191026020752 Sulfate transporter family; Region: Sulfate_transp; pfam00916 191026020753 Sulfate transporter family; Region: Sulfate_transp; pfam00916 191026020754 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 191026020755 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 191026020756 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 191026020757 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 191026020758 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 191026020759 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 191026020760 catalytic residue [active] 191026020761 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 191026020762 FAD binding domain; Region: FAD_binding_4; pfam01565 191026020763 FAD linked oxidases, C-terminal domain; Region: FAD-oxidase_C; pfam02913 191026020764 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 191026020765 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 191026020766 Cysteine-rich domain; Region: CCG; pfam02754 191026020767 Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652 191026020768 YceG-like family; Region: YceG; pfam02618 191026020769 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 191026020770 dimerization interface [polypeptide binding]; other site 191026020771 Predicted permease; Region: DUF318; cl17795 191026020772 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 191026020773 dimerization interface [polypeptide binding]; other site 191026020774 putative DNA binding site [nucleotide binding]; other site 191026020775 putative Zn2+ binding site [ion binding]; other site 191026020776 Putative molybdenum carrier; Region: MoCo_carrier; pfam12694 191026020777 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 191026020778 dimerization interface [polypeptide binding]; other site 191026020779 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 191026020780 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 191026020781 putative active site [active] 191026020782 heme pocket [chemical binding]; other site 191026020783 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 191026020784 dimer interface [polypeptide binding]; other site 191026020785 phosphorylation site [posttranslational modification] 191026020786 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 191026020787 ATP binding site [chemical binding]; other site 191026020788 Mg2+ binding site [ion binding]; other site 191026020789 G-X-G motif; other site 191026020790 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 191026020791 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 191026020792 active site 191026020793 phosphorylation site [posttranslational modification] 191026020794 intermolecular recognition site; other site 191026020795 dimerization interface [polypeptide binding]; other site 191026020796 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 191026020797 Type I periplasmic binding domain of uncharacterized extracellular ligand-binding proteins; Region: PBP1_STKc_like; cd06326 191026020798 putative ligand binding site [chemical binding]; other site 191026020799 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 191026020800 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 191026020801 Zn2+ binding site [ion binding]; other site 191026020802 Mg2+ binding site [ion binding]; other site 191026020803 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 191026020804 Response regulator receiver domain; Region: Response_reg; pfam00072 191026020805 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 191026020806 active site 191026020807 phosphorylation site [posttranslational modification] 191026020808 intermolecular recognition site; other site 191026020809 dimerization interface [polypeptide binding]; other site 191026020810 Type I periplasmic binding domain of uncharacterized extracellular ligand-binding proteins; Region: PBP1_STKc_like; cd06326 191026020811 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 191026020812 putative ligand binding site [chemical binding]; other site 191026020813 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 191026020814 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 191026020815 putative active site [active] 191026020816 heme pocket [chemical binding]; other site 191026020817 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 191026020818 dimer interface [polypeptide binding]; other site 191026020819 phosphorylation site [posttranslational modification] 191026020820 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 191026020821 ATP binding site [chemical binding]; other site 191026020822 Mg2+ binding site [ion binding]; other site 191026020823 G-X-G motif; other site 191026020824 Response regulator receiver domain; Region: Response_reg; pfam00072 191026020825 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 191026020826 active site 191026020827 phosphorylation site [posttranslational modification] 191026020828 intermolecular recognition site; other site 191026020829 dimerization interface [polypeptide binding]; other site 191026020830 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 191026020831 anti sigma factor interaction site; other site 191026020832 regulatory phosphorylation site [posttranslational modification]; other site 191026020833 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 191026020834 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 191026020835 ABC-ATPase subunit interface; other site 191026020836 dimer interface [polypeptide binding]; other site 191026020837 putative PBP binding regions; other site 191026020838 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 191026020839 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 191026020840 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 191026020841 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 191026020842 tetramer interface [polypeptide binding]; other site 191026020843 pyridoxal 5'-phosphate binding site [chemical binding]; other site 191026020844 catalytic residue [active] 191026020845 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ACT14924; Region: LPLAT_ACT14924-like; cd07986 191026020846 putative acyl-acceptor binding pocket; other site 191026020847 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; pfam13444 191026020848 N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853 191026020849 malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402 191026020850 Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325 191026020851 catalytic site [active] 191026020852 active site 191026020853 4-alpha-glucanotransferase; Provisional; Region: PRK14508 191026020854 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 191026020855 S-adenosylmethionine binding site [chemical binding]; other site 191026020856 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 191026020857 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900 191026020858 GT_2_like_a represents a glycosyltransferase family-2 subfamily with unknown function; Region: GT_2_like_a; cd02522 191026020859 transferase 2, rSAM/selenodomain-associated; Region: glyco_like_mftF; TIGR04283 191026020860 Probable Catalytic site; other site 191026020861 transferase 1, rSAM/selenodomain-associated; Region: glyco_like_cofC; TIGR04282 191026020862 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 191026020863 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 191026020864 trmE is a tRNA modification GTPase; Region: trmE; cd04164 191026020865 G1 box; other site 191026020866 GTP/Mg2+ binding site [chemical binding]; other site 191026020867 Switch I region; other site 191026020868 G2 box; other site 191026020869 Switch II region; other site 191026020870 G3 box; other site 191026020871 G4 box; other site 191026020872 G5 box; other site 191026020873 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 191026020874 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 191026020875 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 191026020876 G-X-X-G motif; other site 191026020877 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 191026020878 RxxxH motif; other site 191026020879 membrane protein insertase; Provisional; Region: PRK01318 191026020880 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 191026020881 Ribonuclease P; Region: Ribonuclease_P; pfam00825 191026020882 Ribosomal protein L34; Region: Ribosomal_L34; cl00370 191026020883 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 191026020884 hypothetical protein; Provisional; Region: PRK04334 191026020885 Domain of unknown function DUF77; Region: DUF77; pfam01910 191026020886 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 191026020887 FeS/SAM binding site; other site 191026020888 Domain of unknown function (DUF4008); Region: DUF4008; pfam13186 191026020889 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 191026020890 homodimer interface [polypeptide binding]; other site 191026020891 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 191026020892 active site pocket [active] 191026020893 Beta-lactamase; Region: Beta-lactamase; pfam00144 191026020894 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 191026020895 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 191026020896 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 191026020897 Walker A/P-loop; other site 191026020898 ATP binding site [chemical binding]; other site 191026020899 Q-loop/lid; other site 191026020900 ABC transporter signature motif; other site 191026020901 Walker B; other site 191026020902 D-loop; other site 191026020903 H-loop/switch region; other site 191026020904 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 191026020905 dimer interface [polypeptide binding]; other site 191026020906 conserved gate region; other site 191026020907 putative PBP binding loops; other site 191026020908 ABC-ATPase subunit interface; other site 191026020909 PBP superfamily domain; Region: PBP_like_2; pfam12849 191026020910 FdhD/NarQ family; Region: FdhD-NarQ; pfam02634 191026020911 Protein involved in formate dehydrogenase formation; Region: FdhE; pfam04216 191026020912 formate dehydrogenase accessory protein FdhE; Region: FdhE; TIGR01562 191026020913 molybdenum cofactor biosynthesis protein A, bacterial; Region: moaA; TIGR02666 191026020914 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 191026020915 FeS/SAM binding site; other site 191026020916 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 191026020917 Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760 191026020918 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; cl01481 191026020919 Cache domain; Region: Cache_1; pfam02743 191026020920 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 191026020921 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 191026020922 metal binding site [ion binding]; metal-binding site 191026020923 active site 191026020924 I-site; other site 191026020925 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 191026020926 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 191026020927 Walker A motif; other site 191026020928 ATP binding site [chemical binding]; other site 191026020929 Walker B motif; other site 191026020930 arginine finger; other site 191026020931 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 191026020932 Holliday junction DNA helicase RuvA; Provisional; Region: ruvA; PRK14602 191026020933 RuvA N terminal domain; Region: RuvA_N; pfam01330 191026020934 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 191026020935 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 191026020936 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 191026020937 active site 191026020938 putative DNA-binding cleft [nucleotide binding]; other site 191026020939 dimer interface [polypeptide binding]; other site 191026020940 hypothetical protein; Validated; Region: PRK00110 191026020941 23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293 191026020942 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 191026020943 S-adenosylmethionine binding site [chemical binding]; other site 191026020944 DUF based on E. rectale Gene description (DUF3880); Region: DUF3880; pfam12996 191026020945 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 191026020946 outer membrane lipoprotein; Provisional; Region: PRK11023 191026020947 BON domain; Region: BON; pfam04972 191026020948 Transcriptional regulators [Transcription]; Region: FadR; COG2186 191026020949 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 191026020950 DNA-binding site [nucleotide binding]; DNA binding site 191026020951 FCD domain; Region: FCD; pfam07729 191026020952 Cache domain; Region: Cache_1; pfam02743 191026020953 HAMP domain; Region: HAMP; pfam00672 191026020954 dimerization interface [polypeptide binding]; other site 191026020955 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 191026020956 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 191026020957 dimer interface [polypeptide binding]; other site 191026020958 putative CheW interface [polypeptide binding]; other site 191026020959 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 191026020960 dimerization interface [polypeptide binding]; other site 191026020961 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 191026020962 PAS fold; Region: PAS_3; pfam08447 191026020963 putative active site [active] 191026020964 heme pocket [chemical binding]; other site 191026020965 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 191026020966 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 191026020967 dimer interface [polypeptide binding]; other site 191026020968 phosphorylation site [posttranslational modification] 191026020969 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 191026020970 ATP binding site [chemical binding]; other site 191026020971 Mg2+ binding site [ion binding]; other site 191026020972 G-X-G motif; other site 191026020973 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 191026020974 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 191026020975 AsnC family; Region: AsnC_trans_reg; pfam01037 191026020976 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 191026020977 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 191026020978 substrate-cofactor binding pocket; other site 191026020979 pyridoxal 5'-phosphate binding site [chemical binding]; other site 191026020980 catalytic residue [active] 191026020981 L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396 191026020982 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 191026020983 NAD(P) binding site [chemical binding]; other site 191026020984 AsmA family; Region: AsmA; pfam05170 191026020985 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 191026020986 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 191026020987 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 191026020988 dimer interface [polypeptide binding]; other site 191026020989 putative CheW interface [polypeptide binding]; other site 191026020990 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 191026020991 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 191026020992 DNA binding residues [nucleotide binding] 191026020993 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 191026020994 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 191026020995 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 191026020996 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 191026020997 protein binding site [polypeptide binding]; other site 191026020998 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 191026020999 protein binding site [polypeptide binding]; other site 191026021000 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK14615 191026021001 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 191026021002 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 191026021003 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 191026021004 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 191026021005 active site 191026021006 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 191026021007 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 191026021008 5S rRNA interface [nucleotide binding]; other site 191026021009 CTC domain interface [polypeptide binding]; other site 191026021010 L16 interface [polypeptide binding]; other site 191026021011 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 191026021012 putative active site [active] 191026021013 catalytic residue [active] 191026021014 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588 191026021015 transcription termination factor Rho; Provisional; Region: rho; PRK09376 191026021016 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 191026021017 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 191026021018 RNA binding site [nucleotide binding]; other site 191026021019 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 191026021020 multimer interface [polypeptide binding]; other site 191026021021 Walker A motif; other site 191026021022 ATP binding site [chemical binding]; other site 191026021023 Walker B motif; other site 191026021024 Peptidase family M48; Region: Peptidase_M48; pfam01435 191026021025 TPR repeat; Region: TPR_11; pfam13414 191026021026 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 191026021027 binding surface 191026021028 TPR motif; other site 191026021029 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 191026021030 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 191026021031 active site 191026021032 Riboflavin kinase; Region: Flavokinase; pfam01687 191026021033 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 191026021034 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 191026021035 Cl- selectivity filter; other site 191026021036 Cl- binding residues [ion binding]; other site 191026021037 pore gating glutamate residue; other site 191026021038 dimer interface [polypeptide binding]; other site 191026021039 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with either the SpoIVFB domain (sporulation protein, stage IV cell wall formation, F locus, promoter-distal B) or the chloride channel protein EriC; Region: CBS_pair_SpoIVFB_EriC_assoc2; cd04613 191026021040 FOG: CBS domain [General function prediction only]; Region: COG0517 191026021041 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 191026021042 active site 191026021043 HslU subunit interaction site [polypeptide binding]; other site 191026021044 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 191026021045 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 191026021046 Walker A motif; other site 191026021047 ATP binding site [chemical binding]; other site 191026021048 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 191026021049 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 191026021050 TPR repeat; Region: TPR_11; pfam13414 191026021051 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 191026021052 binding surface 191026021053 TPR motif; other site 191026021054 Tetratricopeptide repeat; Region: TPR_12; pfam13424 191026021055 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 191026021056 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 191026021057 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 191026021058 Uncharacterized family of ferritin-like proteins found in archaea and bacteria; Region: Ferritin_like_AB; cd01045 191026021059 diiron binding motif [ion binding]; other site 191026021060 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086 191026021061 putative binding surface; other site 191026021062 active site 191026021063 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 191026021064 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 191026021065 pyridoxal 5'-phosphate binding site [chemical binding]; other site 191026021066 homodimer interface [polypeptide binding]; other site 191026021067 catalytic residue [active] 191026021068 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 191026021069 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 191026021070 dimerization interface [polypeptide binding]; other site 191026021071 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 191026021072 dimer interface [polypeptide binding]; other site 191026021073 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 191026021074 putative CheW interface [polypeptide binding]; other site 191026021075 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 191026021076 Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_12; cd06347 191026021077 putative ligand binding site [chemical binding]; other site 191026021078 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 191026021079 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 191026021080 TM-ABC transporter signature motif; other site 191026021081 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 191026021082 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 191026021083 TM-ABC transporter signature motif; other site 191026021084 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 191026021085 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 191026021086 Walker A/P-loop; other site 191026021087 ATP binding site [chemical binding]; other site 191026021088 Q-loop/lid; other site 191026021089 ABC transporter signature motif; other site 191026021090 Walker B; other site 191026021091 D-loop; other site 191026021092 H-loop/switch region; other site 191026021093 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 191026021094 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 191026021095 Walker A/P-loop; other site 191026021096 ATP binding site [chemical binding]; other site 191026021097 Q-loop/lid; other site 191026021098 ABC transporter signature motif; other site 191026021099 Walker B; other site 191026021100 D-loop; other site 191026021101 H-loop/switch region; other site 191026021102 hypothetical protein; Provisional; Region: PRK10578 191026021103 UPF0126 domain; Region: UPF0126; pfam03458 191026021104 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 191026021105 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 191026021106 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 191026021107 putative active site [active] 191026021108 putative substrate binding site [chemical binding]; other site 191026021109 putative cosubstrate binding site; other site 191026021110 catalytic site [active] 191026021111 Radical SAM superfamily; Region: Radical_SAM; pfam04055 191026021112 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 191026021113 FeS/SAM binding site; other site 191026021114 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK08270 191026021115 ATP cone domain; Region: ATP-cone; pfam03477 191026021116 Class III ribonucleotide reductase; Region: RNR_III; cd01675 191026021117 effector binding site; other site 191026021118 active site 191026021119 Zn binding site [ion binding]; other site 191026021120 glycine loop; other site 191026021121 Response regulator receiver domain; Region: Response_reg; pfam00072 191026021122 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 191026021123 active site 191026021124 phosphorylation site [posttranslational modification] 191026021125 intermolecular recognition site; other site 191026021126 dimerization interface [polypeptide binding]; other site 191026021127 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 191026021128 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 191026021129 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 191026021130 EAL domain; Region: EAL; pfam00563 191026021131 Predicted signal transduction protein containing EAL and modified HD-GYP domains [Signal transduction mechanisms]; Region: COG3434 191026021132 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 191026021133 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 191026021134 Domain of unknown function (DUF1844); Region: DUF1844; pfam08899 191026021135 DNA polymerase I; Provisional; Region: PRK05755 191026021136 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 191026021137 active site 191026021138 metal binding site 1 [ion binding]; metal-binding site 191026021139 putative 5' ssDNA interaction site; other site 191026021140 metal binding site 3; metal-binding site 191026021141 metal binding site 2 [ion binding]; metal-binding site 191026021142 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 191026021143 putative DNA binding site [nucleotide binding]; other site 191026021144 putative metal binding site [ion binding]; other site 191026021145 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 191026021146 active site 191026021147 substrate binding site [chemical binding]; other site 191026021148 catalytic site [active] 191026021149 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 191026021150 active site 191026021151 DNA binding site [nucleotide binding] 191026021152 catalytic site [active] 191026021153 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 191026021154 DHH family; Region: DHH; pfam01368 191026021155 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 191026021156 Walker A motif; other site 191026021157 ATP binding site [chemical binding]; other site 191026021158 Walker B motif; other site 191026021159 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 191026021160 PHP family phosphoesterase with a Zn ribbon [General function prediction only]; Region: COG1379 191026021161 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 191026021162 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 191026021163 Part of AAA domain; Region: AAA_19; pfam13245 191026021164 Family description; Region: UvrD_C_2; pfam13538 191026021165 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 191026021166 zinc transporter ZupT; Provisional; Region: PRK04201 191026021167 ZIP Zinc transporter; Region: Zip; pfam02535 191026021168 putative cation:proton antiport protein; Provisional; Region: PRK10669 191026021169 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 191026021170 TrkA-N domain; Region: TrkA_N; pfam02254 191026021171 TrkA-C domain; Region: TrkA_C; pfam02080 191026021172 DnaK suppressor protein [Signal transduction mechanisms]; Region: DksA; COG1734 191026021173 Cache domain; Region: Cache_1; pfam02743 191026021174 HAMP domain; Region: HAMP; pfam00672 191026021175 PAS domain; Region: PAS_9; pfam13426 191026021176 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 191026021177 putative active site [active] 191026021178 heme pocket [chemical binding]; other site 191026021179 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 191026021180 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 191026021181 dimer interface [polypeptide binding]; other site 191026021182 putative CheW interface [polypeptide binding]; other site 191026021183 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 191026021184 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 191026021185 Walker A/P-loop; other site 191026021186 ATP binding site [chemical binding]; other site 191026021187 Q-loop/lid; other site 191026021188 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 191026021189 ABC transporter; Region: ABC_tran_2; pfam12848 191026021190 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 191026021191 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 191026021192 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 191026021193 metal binding site [ion binding]; metal-binding site 191026021194 active site 191026021195 I-site; other site 191026021196 PAS domain S-box; Region: sensory_box; TIGR00229 191026021197 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 191026021198 putative active site [active] 191026021199 heme pocket [chemical binding]; other site 191026021200 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 191026021201 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 191026021202 metal binding site [ion binding]; metal-binding site 191026021203 active site 191026021204 I-site; other site 191026021205 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 191026021206 VacJ like lipoprotein; Region: VacJ; cl01073 191026021207 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 191026021208 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_2; cd03138 191026021209 conserved cys residue [active] 191026021210 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 191026021211 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 191026021212 Isochorismatase family; Region: Isochorismatase; pfam00857 191026021213 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 191026021214 catalytic triad [active] 191026021215 conserved cis-peptide bond; other site 191026021216 Domain of unknown function (DUF4198); Region: DUF4198; pfam10670 191026021217 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 191026021218 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 191026021219 metal binding site [ion binding]; metal-binding site 191026021220 putative dimer interface [polypeptide binding]; other site 191026021221 Protein of unknown function (DUF3100); Region: DUF3100; pfam11299 191026021222 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 191026021223 active site 191026021224 Predicted membrane protein (DUF2335); Region: DUF2335; pfam10097 191026021225 Peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: MsrA; COG0225 191026021226 methionine sulfoxide reductase B; Provisional; Region: PRK00222 191026021227 SelR domain; Region: SelR; pfam01641 191026021228 D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813 191026021229 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_2; cd06310 191026021230 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 191026021231 putative ligand binding site [chemical binding]; other site 191026021232 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466 191026021233 uncharacterized subgroup of aldehyde reductase and flavonoid reductase related proteins, extended (e) SDRs; Region: AR_FR_like_1_SDR_e; cd05228 191026021234 putative NADP binding site [chemical binding]; other site 191026021235 putative substrate binding site [chemical binding]; other site 191026021236 active site 191026021237 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 191026021238 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 191026021239 active site 191026021240 phosphorylation site [posttranslational modification] 191026021241 intermolecular recognition site; other site 191026021242 dimerization interface [polypeptide binding]; other site 191026021243 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 191026021244 binding surface 191026021245 TPR motif; other site 191026021246 TPR repeat; Region: TPR_11; pfam13414 191026021247 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 191026021248 binding surface 191026021249 TPR motif; other site 191026021250 TPR repeat; Region: TPR_11; pfam13414 191026021251 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 191026021252 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 191026021253 DNA binding site [nucleotide binding] 191026021254 active site 191026021255 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 191026021256 dimerization interface [polypeptide binding]; other site 191026021257 PAS domain S-box; Region: sensory_box; TIGR00229 191026021258 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 191026021259 putative active site [active] 191026021260 heme pocket [chemical binding]; other site 191026021261 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 191026021262 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 191026021263 metal binding site [ion binding]; metal-binding site 191026021264 active site 191026021265 I-site; other site 191026021266 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 191026021267 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 191026021268 Uncharacterized conserved protein [Function unknown]; Region: COG1359 191026021269 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 191026021270 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 191026021271 putative substrate translocation pore; other site 191026021272 Protein of unknown function (DUF3365); Region: DUF3365; pfam11845 191026021273 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 191026021274 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 191026021275 putative active site [active] 191026021276 heme pocket [chemical binding]; other site 191026021277 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 191026021278 ATP binding site [chemical binding]; other site 191026021279 Mg2+ binding site [ion binding]; other site 191026021280 G-X-G motif; other site 191026021281 Ion channel; Region: Ion_trans_2; pfam07885 191026021282 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 191026021283 TrkA-N domain; Region: TrkA_N; pfam02254 191026021284 TrkA-C domain; Region: TrkA_C; pfam02080 191026021285 Predicted membrane protein [Function unknown]; Region: COG3152 191026021286 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 191026021287 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 191026021288 dimer interface [polypeptide binding]; other site 191026021289 putative CheW interface [polypeptide binding]; other site 191026021290 Hemerythrin; Region: Hemerythrin; cd12107 191026021291 Fe binding site [ion binding]; other site 191026021292 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 191026021293 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 191026021294 dimerization interface [polypeptide binding]; other site 191026021295 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 191026021296 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 191026021297 metal binding site [ion binding]; metal-binding site 191026021298 active site 191026021299 I-site; other site 191026021300 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 191026021301 Periplasmic binding component of a family of basic membrane lipoproteins from Borrelia and various putative lipoproteins from other bacteria; Region: PBP1_BmpA_like; cd06304 191026021302 ligand binding site [chemical binding]; other site 191026021303 Peroxiredoxin (PRX) family, AhpE-like subfamily; composed of proteins similar to Mycobacterium tuberculosis AhpE. AhpE is described as a 1-cys PRX because of the absence of a resolving cysteine. The structure and sequence of AhpE, however, show greater...; Region: PRX_AhpE_like; cd03018 191026021304 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 191026021305 dimer interface [polypeptide binding]; other site 191026021306 catalytic triad [active] 191026021307 Protein of unknown function, DUF481; Region: DUF481; pfam04338 191026021308 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 191026021309 ApbE family; Region: ApbE; pfam02424 191026021310 Putative Fe-S cluster; Region: FeS; cl17515 191026021311 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 191026021312 4Fe-4S binding domain; Region: Fer4; pfam00037 191026021313 dihydropyrimidine dehydrogenase subunit A; Provisional; Region: PRK11749 191026021314 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 191026021315 electron transport complex, RnfABCDGE type, A subunit; Region: rnfA; TIGR01943 191026021316 electron transport complex RsxE subunit; Provisional; Region: PRK12405 191026021317 FMN-binding domain; Region: FMN_bind; cl01081 191026021318 NQR2, RnfD, RnfE family; Region: NQR2_RnfD_RnfE; pfam03116 191026021319 electron transport complex, RnfABCDGE type, C subunit; Region: rnfC; TIGR01945 191026021320 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 191026021321 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168 191026021322 heme-binding residues [chemical binding]; other site 191026021323 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 191026021324 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 191026021325 dimerization interface [polypeptide binding]; other site 191026021326 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 191026021327 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 191026021328 dimer interface [polypeptide binding]; other site 191026021329 putative CheW interface [polypeptide binding]; other site 191026021330 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 191026021331 TMAO reductase system periplasmic protein TorT; Region: TMAO_TorT; TIGR02955 191026021332 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 191026021333 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 191026021334 substrate binding pocket [chemical binding]; other site 191026021335 membrane-bound complex binding site; other site 191026021336 hinge residues; other site 191026021337 PAS domain S-box; Region: sensory_box; TIGR00229 191026021338 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 191026021339 putative active site [active] 191026021340 heme pocket [chemical binding]; other site 191026021341 PAS domain S-box; Region: sensory_box; TIGR00229 191026021342 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 191026021343 putative active site [active] 191026021344 heme pocket [chemical binding]; other site 191026021345 GAF domain; Region: GAF_2; pfam13185 191026021346 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 191026021347 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 191026021348 PAS fold; Region: PAS_3; pfam08447 191026021349 putative active site [active] 191026021350 heme pocket [chemical binding]; other site 191026021351 PAS fold; Region: PAS_4; pfam08448 191026021352 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 191026021353 putative active site [active] 191026021354 heme pocket [chemical binding]; other site 191026021355 PAS domain S-box; Region: sensory_box; TIGR00229 191026021356 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 191026021357 putative active site [active] 191026021358 heme pocket [chemical binding]; other site 191026021359 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 191026021360 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 191026021361 metal binding site [ion binding]; metal-binding site 191026021362 active site 191026021363 I-site; other site 191026021364 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390 191026021365 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4619 191026021366 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 191026021367 Walker A/P-loop; other site 191026021368 ATP binding site [chemical binding]; other site 191026021369 Q-loop/lid; other site 191026021370 ABC transporter signature motif; other site 191026021371 Walker B; other site 191026021372 D-loop; other site 191026021373 H-loop/switch region; other site 191026021374 Peptidase family M48; Region: Peptidase_M48; pfam01435 191026021375 Tetratricopeptide repeat; Region: TPR_16; pfam13432 191026021376 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 191026021377 binding surface 191026021378 TPR motif; other site 191026021379 Tetratricopeptide repeat; Region: TPR_16; pfam13432 191026021380 malate synthase G; Provisional; Region: PRK02999 191026021381 active site 191026021382 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 191026021383 nitrogen fixation negative regulator NifL; Region: nifL_nitrog; TIGR02938 191026021384 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 191026021385 putative active site [active] 191026021386 heme pocket [chemical binding]; other site 191026021387 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 191026021388 putative active site [active] 191026021389 heme pocket [chemical binding]; other site 191026021390 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 191026021391 dimer interface [polypeptide binding]; other site 191026021392 phosphorylation site [posttranslational modification] 191026021393 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 191026021394 ATP binding site [chemical binding]; other site 191026021395 Mg2+ binding site [ion binding]; other site 191026021396 G-X-G motif; other site 191026021397 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 191026021398 nucleotide binding site [chemical binding]; other site 191026021399 substrate binding site [chemical binding]; other site 191026021400 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 191026021401 Sulfate transporter family; Region: Sulfate_transp; pfam00916 191026021402 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 191026021403 putative trimer interface [polypeptide binding]; other site 191026021404 putative CoA binding site [chemical binding]; other site 191026021405 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 191026021406 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 191026021407 PAS fold; Region: PAS; pfam00989 191026021408 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 191026021409 putative active site [active] 191026021410 heme pocket [chemical binding]; other site 191026021411 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 191026021412 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 191026021413 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 191026021414 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 191026021415 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 191026021416 dimer interface [polypeptide binding]; other site 191026021417 conserved gate region; other site 191026021418 putative PBP binding loops; other site 191026021419 ABC-ATPase subunit interface; other site 191026021420 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 191026021421 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 191026021422 Walker A/P-loop; other site 191026021423 ATP binding site [chemical binding]; other site 191026021424 Q-loop/lid; other site 191026021425 ABC transporter signature motif; other site 191026021426 Walker B; other site 191026021427 D-loop; other site 191026021428 H-loop/switch region; other site 191026021429 benzoyl-CoA reductase, subunit C; Region: benz_CoA_red_C; TIGR02263 191026021430 2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050 191026021431 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 191026021432 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 191026021433 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 191026021434 dimerization interface [polypeptide binding]; other site 191026021435 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 191026021436 dimer interface [polypeptide binding]; other site 191026021437 phosphorylation site [posttranslational modification] 191026021438 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 191026021439 ATP binding site [chemical binding]; other site 191026021440 Mg2+ binding site [ion binding]; other site 191026021441 G-X-G motif; other site 191026021442 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 191026021443 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 191026021444 active site 191026021445 phosphorylation site [posttranslational modification] 191026021446 intermolecular recognition site; other site 191026021447 dimerization interface [polypeptide binding]; other site 191026021448 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 191026021449 Walker A motif; other site 191026021450 ATP binding site [chemical binding]; other site 191026021451 Walker B motif; other site 191026021452 arginine finger; other site 191026021453 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 191026021454 Response regulator receiver domain; Region: Response_reg; pfam00072 191026021455 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 191026021456 active site 191026021457 phosphorylation site [posttranslational modification] 191026021458 intermolecular recognition site; other site 191026021459 dimerization interface [polypeptide binding]; other site 191026021460 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 191026021461 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 191026021462 Walker A motif; other site 191026021463 ATP binding site [chemical binding]; other site 191026021464 Walker B motif; other site 191026021465 arginine finger; other site 191026021466 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 191026021467 DNA topoisomerase IV subunit A; Provisional; Region: PRK13979 191026021468 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 191026021469 TrkA-C domain; Region: TrkA_C; pfam02080 191026021470 TrkA-C domain; Region: TrkA_C; pfam02080 191026021471 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 191026021472 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 191026021473 sodium/proton antiporter; Reviewed; Region: nhaB; PRK09547 191026021474 Methyltransferase domain; Region: Methyltransf_31; pfam13847 191026021475 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 191026021476 S-adenosylmethionine binding site [chemical binding]; other site