-- dump date   	20140619_063929
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
696281000001	chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149
696281000002	DnaA N-terminal domain; Region: DnaA_N; pfam11638
696281000003	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
696281000004	Walker A motif; other site
696281000005	ATP binding site [chemical binding]; other site
696281000006	Walker B motif; other site
696281000007	arginine finger; other site
696281000008	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
696281000009	DnaA box-binding interface [nucleotide binding]; other site
696281000010	DNA polymerase III subunit beta; Validated; Region: PRK05643
696281000011	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
696281000012	putative DNA binding surface [nucleotide binding]; other site
696281000013	dimer interface [polypeptide binding]; other site
696281000014	beta-clamp/clamp loader binding surface; other site
696281000015	beta-clamp/translesion DNA polymerase binding surface; other site
696281000016	S4 domain; Region: S4_2; pfam13275
696281000017	recombination protein F; Reviewed; Region: recF; PRK00064
696281000018	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
696281000019	Walker A/P-loop; other site
696281000020	ATP binding site [chemical binding]; other site
696281000021	Q-loop/lid; other site
696281000022	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
696281000023	ABC transporter signature motif; other site
696281000024	Walker B; other site
696281000025	D-loop; other site
696281000026	H-loop/switch region; other site
696281000027	DNA gyrase subunit B; Validated; Region: gyrB; PRK05644
696281000028	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
696281000029	Mg2+ binding site [ion binding]; other site
696281000030	G-X-G motif; other site
696281000031	Y-family of DNA polymerases; Region: PolY; cl12025
696281000032	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
696281000033	anchoring element; other site
696281000034	dimer interface [polypeptide binding]; other site
696281000035	ATP binding site [chemical binding]; other site
696281000036	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
696281000037	active site
696281000038	putative metal-binding site [ion binding]; other site
696281000039	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
696281000040	Methyltransferase domain; Region: Methyltransf_23; pfam13489
696281000041	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
696281000042	S-adenosylmethionine binding site [chemical binding]; other site
696281000043	DNA gyrase subunit A; Validated; Region: PRK05560
696281000044	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
696281000045	CAP-like domain; other site
696281000046	active site
696281000047	primary dimer interface [polypeptide binding]; other site
696281000048	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
696281000049	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
696281000050	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
696281000051	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
696281000052	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
696281000053	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
696281000054	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
696281000055	Zn2+ binding site [ion binding]; other site
696281000056	Mg2+ binding site [ion binding]; other site
696281000057	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
696281000058	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
696281000059	Zn2+ binding site [ion binding]; other site
696281000060	Mg2+ binding site [ion binding]; other site
696281000061	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964
696281000062	YheO-like PAS domain; Region: PAS_6; pfam08348
696281000063	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
696281000064	DNA-binding interface [nucleotide binding]; DNA binding site
696281000065	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
696281000066	homotrimer interaction site [polypeptide binding]; other site
696281000067	putative active site [active]
696281000068	threonine synthase; Validated; Region: PRK08197
696281000069	Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of  threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563
696281000070	homodimer interface [polypeptide binding]; other site
696281000071	pyridoxal 5'-phosphate binding site [chemical binding]; other site
696281000072	catalytic residue [active]
696281000073	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
696281000074	Sodium:dicarboxylate symporter family; Region: SDF; cl00573
696281000075	pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343
696281000076	PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP,  present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727
696281000077	active site
696281000078	multimer interface [polypeptide binding]; other site
696281000079	Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749
696281000080	Glutamine amidotransferase [Amino acid transport and metabolism]; Region: HisH; COG0118
696281000081	predicted active site [active]
696281000082	catalytic triad [active]
696281000083	N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247
696281000084	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
696281000085	Alanine-glyoxylate aminotransferase (AGAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to alanine-glyoxylate aminotransferase (AGAT); Region: AGAT_like; cd06451
696281000086	homodimer interface [polypeptide binding]; other site
696281000087	pyridoxal 5'-phosphate binding site [chemical binding]; other site
696281000088	catalytic residue [active]
696281000089	D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581
696281000090	Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173
696281000091	ligand binding site [chemical binding]; other site
696281000092	NAD binding site [chemical binding]; other site
696281000093	dimerization interface [polypeptide binding]; other site
696281000094	catalytic site [active]
696281000095	C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902
696281000096	putative L-serine binding site [chemical binding]; other site
696281000097	seryl-tRNA synthetase; Provisional; Region: PRK05431
696281000098	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
696281000099	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770
696281000100	dimer interface [polypeptide binding]; other site
696281000101	active site
696281000102	motif 1; other site
696281000103	motif 2; other site
696281000104	motif 3; other site
696281000105	SnoaL-like domain; Region: SnoaL_2; pfam12680
696281000106	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205
696281000107	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
696281000108	nucleoside/Zn binding site; other site
696281000109	dimer interface [polypeptide binding]; other site
696281000110	catalytic motif [active]
696281000111	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
696281000112	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
696281000113	active site
696281000114	phosphorylation site [posttranslational modification]
696281000115	intermolecular recognition site; other site
696281000116	dimerization interface [polypeptide binding]; other site
696281000117	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
696281000118	DNA binding site [nucleotide binding]
696281000119	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
696281000120	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
696281000121	dimer interface [polypeptide binding]; other site
696281000122	phosphorylation site [posttranslational modification]
696281000123	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
696281000124	ATP binding site [chemical binding]; other site
696281000125	Mg2+ binding site [ion binding]; other site
696281000126	G-X-G motif; other site
696281000127	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
696281000128	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768
696281000129	Domain of unknown function (DUF1992); Region: DUF1992; pfam09350
696281000130	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
696281000131	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
696281000132	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
696281000133	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
696281000134	dimer interface [polypeptide binding]; other site
696281000135	conserved gate region; other site
696281000136	ABC-ATPase subunit interface; other site
696281000137	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
696281000138	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
696281000139	dimer interface [polypeptide binding]; other site
696281000140	conserved gate region; other site
696281000141	putative PBP binding loops; other site
696281000142	ABC-ATPase subunit interface; other site
696281000143	HlyD family secretion protein; Region: HlyD_2; pfam12700
696281000144	PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cl00162
696281000145	HlyD family secretion protein; Region: HlyD_3; pfam13437
696281000146	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
696281000147	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
696281000148	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
696281000149	Walker A/P-loop; other site
696281000150	ATP binding site [chemical binding]; other site
696281000151	Q-loop/lid; other site
696281000152	ABC transporter signature motif; other site
696281000153	Walker B; other site
696281000154	D-loop; other site
696281000155	H-loop/switch region; other site
696281000156	TOBE domain; Region: TOBE_2; pfam08402
696281000157	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
696281000158	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
696281000159	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
696281000160	active site 1 [active]
696281000161	Acyl-ACP thioesterase; Region: Acyl-ACP_TE; pfam01643
696281000162	active site 2 [active]
696281000163	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
696281000164	Coenzyme A binding pocket [chemical binding]; other site
696281000165	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
696281000166	MarR family; Region: MarR_2; pfam12802
696281000167	Uncharacterized conserved protein [Function unknown]; Region: COG1284
696281000168	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
696281000169	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
696281000170	Helix-Turn-Helix DNA binding domain of the BltR transcription regulator; Region: HTH_BltR; cd04782
696281000171	DNA binding residues [nucleotide binding]
696281000172	dimer interface [polypeptide binding]; other site
696281000173	GyrI-like small molecule binding domain; Region: GyrI-like; cl01368
696281000174	MarR family; Region: MarR_2; pfam12802
696281000175	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
696281000176	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_10; cd07251
696281000177	Predicted branched-chain amino acid permeases (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlD; COG1687
696281000178	4-azaleucine resistance probable transporter AzlC; Region: azlC; TIGR00346
696281000179	Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051
696281000180	Uncharacterized conserved protein [Function unknown]; Region: COG1633
696281000181	dimanganese center [ion binding]; other site
696281000182	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
696281000183	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
696281000184	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
696281000185	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
696281000186	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
696281000187	EamA-like transporter family; Region: EamA; pfam00892
696281000188	EamA-like transporter family; Region: EamA; pfam00892
696281000189	2-isopropylmalate synthase; Validated; Region: PRK00915
696281000190	2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940
696281000191	active site
696281000192	catalytic residues [active]
696281000193	metal binding site [ion binding]; metal-binding site
696281000194	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917
696281000195	Predicted transcriptional regulator [Transcription]; Region: COG2378
696281000196	HTH domain; Region: HTH_11; pfam08279
696281000197	WYL domain; Region: WYL; pfam13280
696281000198	Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871
696281000199	ABC transporter ATP-binding protein; Provisional; Region: PRK15064
696281000200	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
696281000201	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
696281000202	ABC transporter; Region: ABC_tran_2; pfam12848
696281000203	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
696281000204	Arsenate Reductase (ArsC) family; composed of TRX-fold arsenic reductases and similar proteins including the transcriptional regulator, Spx. ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], using reducing equivalents derived from...; Region: ArsC_family; cd02977
696281000205	ArsC family; Region: ArsC; pfam03960
696281000206	catalytic residue [active]
696281000207	pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182
696281000208	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
696281000209	tetramer interface [polypeptide binding]; other site
696281000210	TPP-binding site [chemical binding]; other site
696281000211	heterodimer interface [polypeptide binding]; other site
696281000212	phosphorylation loop region [posttranslational modification]
696281000213	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
696281000214	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
696281000215	alpha subunit interface [polypeptide binding]; other site
696281000216	TPP binding site [chemical binding]; other site
696281000217	heterodimer interface [polypeptide binding]; other site
696281000218	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
696281000219	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
696281000220	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day.  Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803
696281000221	active site
696281000222	FMN binding site [chemical binding]; other site
696281000223	substrate binding site [chemical binding]; other site
696281000224	putative catalytic residue [active]
696281000225	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
696281000226	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
696281000227	active site
696281000228	phosphorylation site [posttranslational modification]
696281000229	intermolecular recognition site; other site
696281000230	dimerization interface [polypeptide binding]; other site
696281000231	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
696281000232	Walker A motif; other site
696281000233	ATP binding site [chemical binding]; other site
696281000234	Walker B motif; other site
696281000235	arginine finger; other site
696281000236	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
696281000237	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256
696281000238	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
696281000239	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
696281000240	dimer interface [polypeptide binding]; other site
696281000241	putative CheW interface [polypeptide binding]; other site
696281000242	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
696281000243	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
696281000244	Zn2+ binding site [ion binding]; other site
696281000245	Mg2+ binding site [ion binding]; other site
696281000246	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
696281000247	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
696281000248	Catalytic site [active]
696281000249	Ferredoxin-like protein [Energy production and conversion]; Region: FixX; COG2440
696281000250	Electron transfer flavoprotein-ubiquinone oxidoreductase; Region: ETF_QO; pfam05187
696281000251	oxidoreductase; Provisional; Region: PRK10015
696281000252	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
696281000253	4Fe-4S binding domain; Region: Fer4; pfam00037
696281000254	Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025
696281000255	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715
696281000256	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
696281000257	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
696281000258	Ligand binding site [chemical binding]; other site
696281000259	Electron transfer flavoprotein domain; Region: ETF; pfam01012
696281000260	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
696281000261	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
696281000262	transmembrane helices; other site
696281000263	Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973
696281000264	Part of AAA domain; Region: AAA_19; pfam13245
696281000265	Family description; Region: UvrD_C_2; pfam13538
696281000266	PAS domain; Region: PAS_9; pfam13426
696281000267	psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974
696281000268	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
696281000269	Walker A motif; other site
696281000270	ATP binding site [chemical binding]; other site
696281000271	Walker B motif; other site
696281000272	arginine finger; other site
696281000273	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
696281000274	Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872
696281000275	active site
696281000276	NAD binding site [chemical binding]; other site
696281000277	metal binding site [ion binding]; metal-binding site
696281000278	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
696281000279	Uncharacterized ALDH (y4uC) with similarity to Tortula ruralis aldehyde dehydrogenase ALDH21A1; Region: ALDH_y4uC; cd07149
696281000280	NAD(P) binding site [chemical binding]; other site
696281000281	catalytic residues [active]
696281000282	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
696281000283	Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173
696281000284	ligand binding site [chemical binding]; other site
696281000285	NAD binding site [chemical binding]; other site
696281000286	dimerization interface [polypeptide binding]; other site
696281000287	catalytic site [active]
696281000288	Malate/L-lactate dehydrogenases [Energy production and conversion]; Region: COG2055
696281000289	Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613
696281000290	D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295
696281000291	benzoate transport; Region: 2A0115; TIGR00895
696281000292	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
696281000293	putative substrate translocation pore; other site
696281000294	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
696281000295	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
696281000296	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
696281000297	haloalkane dehalogenase; Provisional; Region: PRK03592
696281000298	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
696281000299	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
696281000300	ligand binding site [chemical binding]; other site
696281000301	flexible hinge region; other site
696281000302	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
696281000303	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
696281000304	Walker A motif; other site
696281000305	ATP binding site [chemical binding]; other site
696281000306	Walker B motif; other site
696281000307	The TGS domain, named after the ThrRS, GTPase, and SpoT/RelA proteins where it occurs, is structurally similar to ubiquitin. TGS is a small domain of about 50 amino acid residues with a predominantly beta-sheet structure. There is no direct information...; Region: TGS; cl15768
696281000308	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469
696281000309	Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572
696281000310	Uridine monophosphate kinase_like (UMPK_like) is a family of proteins highly similar to the uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK); Region: UMPK_like; cd02028
696281000311	active site
696281000312	Uncharacterized conserved protein [Function unknown]; Region: COG2006
696281000313	Domain of unknown function (DUF362); Region: DUF362; pfam04015
696281000314	4Fe-4S binding domain; Region: Fer4; cl02805
696281000315	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
696281000316	4Fe-4S dicluster domain; Region: Fer4_9; pfam13187
696281000317	DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563
696281000318	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
696281000319	Walker A motif; other site
696281000320	ATP binding site [chemical binding]; other site
696281000321	Walker B motif; other site
696281000322	arginine finger; other site
696281000323	DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169
696281000324	hypothetical protein; Validated; Region: PRK00153
696281000325	recombination protein RecR; Reviewed; Region: recR; PRK00076
696281000326	RecR protein; Region: RecR; pfam02132
696281000327	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
696281000328	putative active site [active]
696281000329	putative metal-binding site [ion binding]; other site
696281000330	tetramer interface [polypeptide binding]; other site
696281000331	SigmaK-factor processing regulatory protein BofA; Region: BofA; cl06466
696281000332	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
696281000333	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
696281000334	2-oxoglutarate ferredoxin oxidoreductase subunit alpha; Validated; Region: PRK08659
696281000335	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
696281000336	dimer interface [polypeptide binding]; other site
696281000337	PYR/PP interface [polypeptide binding]; other site
696281000338	TPP binding site [chemical binding]; other site
696281000339	substrate binding site [chemical binding]; other site
696281000340	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629
696281000341	TPP-binding site [chemical binding]; other site
696281000342	2-oxoglutarate ferredoxin oxidoreductase subunit gamma; Validated; Region: PRK08537
696281000343	Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014
696281000344	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
696281000345	Spore germination protein; Region: Spore_permease; cl17796
696281000346	germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887
696281000347	Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504
696281000348	Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323
696281000349	Spore germination protein; Region: Spore_permease; cl17796
696281000350	Inhibitor of sigma-G Gin; Region: Gin; pfam10764
696281000351	Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982
696281000352	Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615
696281000353	homodimer interface [polypeptide binding]; other site
696281000354	pyridoxal 5'-phosphate binding site [chemical binding]; other site
696281000355	catalytic residue [active]
696281000356	Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711
696281000357	thymidylate kinase; Validated; Region: tmk; PRK00698
696281000358	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
696281000359	TMP-binding site; other site
696281000360	ATP-binding site [chemical binding]; other site
696281000361	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
696281000362	DNA polymerase III, delta subunit; Region: DNA_pol3_delta2; pfam13177
696281000363	Walker A motif; other site
696281000364	ATP binding site [chemical binding]; other site
696281000365	Walker B motif; other site
696281000366	arginine finger; other site
696281000367	Uncharacterized homolog of PSP1 [Function unknown]; Region: COG1774
696281000368	Protein of unknown function (DUF972); Region: DUF972; pfam06156
696281000369	Predicted methyltransferases [General function prediction only]; Region: COG0313
696281000370	Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648
696281000371	putative SAM binding site [chemical binding]; other site
696281000372	putative homodimer interface [polypeptide binding]; other site
696281000373	SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966
696281000374	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
696281000375	Transposase; Region: HTH_Tnp_1; cl17663
696281000376	Helix-turn-helix domain; Region: HTH_28; pfam13518
696281000377	putative transposase OrfB; Reviewed; Region: PHA02517
696281000378	HTH-like domain; Region: HTH_21; pfam13276
696281000379	Integrase core domain; Region: rve; pfam00665
696281000380	Integrase core domain; Region: rve_2; pfam13333
696281000381	methionyl-tRNA synthetase; Reviewed; Region: PRK11893
696281000382	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
696281000383	HIGH motif; other site
696281000384	active site
696281000385	KMSKS motif; other site
696281000386	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
696281000387	tRNA binding surface [nucleotide binding]; other site
696281000388	anticodon binding site; other site
696281000389	Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099
696281000390	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
696281000391	active site
696281000392	ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109
696281000393	ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561
696281000394	homodimer interface [polypeptide binding]; other site
696281000395	Walker A motif; other site
696281000396	ATP binding site [chemical binding]; other site
696281000397	hydroxycobalamin binding site [chemical binding]; other site
696281000398	Walker B motif; other site
696281000399	Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878
696281000400	SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339
696281000401	Domain of unknown function (DUF3794); Region: DUF3794; pfam12673
696281000402	G5 domain; Region: G5; pfam07501
696281000403	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584
696281000404	Domain of unknown function (DUF348); Region: DUF348; pfam03990
696281000405	G5 domain; Region: G5; pfam07501
696281000406	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584
696281000407	Thiamine pyrophosphokinase; Region: TPK; cd07995
696281000408	thiamine pyrophosphokinase; Region: thi_PPkinase; TIGR01378
696281000409	active site
696281000410	dimerization interface [polypeptide binding]; other site
696281000411	thiamine binding site [chemical binding]; other site
696281000412	Domain of unknown function DUF77; Region: DUF77; pfam01910
696281000413	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
696281000414	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
696281000415	ABC-ATPase subunit interface; other site
696281000416	putative PBP binding loops; other site
696281000417	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432
696281000418	NMT1/THI5 like; Region: NMT1; pfam09084
696281000419	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
696281000420	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
696281000421	Walker A/P-loop; other site
696281000422	ATP binding site [chemical binding]; other site
696281000423	Q-loop/lid; other site
696281000424	ABC transporter signature motif; other site
696281000425	Walker B; other site
696281000426	D-loop; other site
696281000427	H-loop/switch region; other site
696281000428	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
696281000429	substrate binding site [chemical binding]; other site
696281000430	dimer interface [polypeptide binding]; other site
696281000431	ATP binding site [chemical binding]; other site
696281000432	thiamine biosynthesis protein ThiC; Provisional; Region: PRK13352
696281000433	thiamine biosynthesis protein ThiC; Region: thiC; TIGR00190
696281000434	haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702
696281000435	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
696281000436	ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565
696281000437	thiS-thiF/thiG interaction site; other site
696281000438	thiazole synthase; Reviewed; Region: thiG; PRK00208
696281000439	phosphate binding site [ion binding]; other site
696281000440	thiamine biosynthesis protein ThiH; Reviewed; Region: thiH; PRK09240
696281000441	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
696281000442	FeS/SAM binding site; other site
696281000443	Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968
696281000444	thiamine biosynthesis protein ThiF; Provisional; Region: PRK08644
696281000445	Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cl17196
696281000446	ATP binding site [chemical binding]; other site
696281000447	substrate interface [chemical binding]; other site
696281000448	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
696281000449	thiamine phosphate binding site [chemical binding]; other site
696281000450	active site
696281000451	pyrophosphate binding site [ion binding]; other site
696281000452	16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274
696281000453	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
696281000454	S-adenosylmethionine binding site [chemical binding]; other site
696281000455	Protein of unknown function (DUF458); Region: DUF458; pfam04308
696281000456	manganese transport transcriptional regulator; Provisional; Region: PRK03902
696281000457	Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325
696281000458	Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742
696281000459	ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803
696281000460	Metal binding protein TroA. These proteins have been shown to function as initial receptors in ABC transport of Zn2+ and possibly Fe3+ in many eubacterial species.  The TroA proteins belong to the TroA superfamily of periplasmic metal binding proteins...; Region: TroA; cd01016
696281000461	metal binding site [ion binding]; metal-binding site
696281000462	intersubunit interface [polypeptide binding]; other site
696281000463	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
696281000464	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
696281000465	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
696281000466	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
696281000467	ABC-ATPase subunit  interface; other site
696281000468	dimer interface [polypeptide binding]; other site
696281000469	putative PBP binding regions; other site
696281000470	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
696281000471	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
696281000472	ABC-ATPase subunit  interface; other site
696281000473	dimer interface [polypeptide binding]; other site
696281000474	putative PBP binding regions; other site
696281000475	YabG peptidase U57; Region: Peptidase_U57; pfam05582
696281000476	Peptidase family S64; Region: Peptidase_S64; pfam08192
696281000477	SCP: SCP-like extracellular protein domain, found in eukaryotes and prokaryotes. This family includes plant pathogenesis-related protein 1 (PR-1), which accumulates after infections with pathogens, and may act as an anti-fungal agent or be involved in...; Region: SCP; cl00133
696281000478	Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340
696281000479	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
696281000480	Domain of unknown function (DUF3794); Region: DUF3794; pfam12673
696281000481	Domain of unknown function (DUF3794); Region: DUF3794; pfam12673
696281000482	Domain of unknown function (DUF3794); Region: DUF3794; pfam12673
696281000483	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
696281000484	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
696281000485	Domain of unknown function (DUF3794); Region: DUF3794; pfam12673
696281000486	YbaB/EbfC DNA-binding family; Region: YbaB_DNA_bd; pfam02575
696281000487	YbaB/EbfC DNA-binding family; Region: YbaB_DNA_bd; pfam02575
696281000488	ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent; Region: NrdJ_Z; TIGR02504
696281000489	Peptidase S8 family domain in Subtilisin proteins; Region: Peptidases_S8_Subtilisin_subset; cd07477
696281000490	active site
696281000491	catalytic residues [active]
696281000492	Copper chaperone [Inorganic ion transport and metabolism]; Region: CopZ; COG2608
696281000493	Protein of unknown function, DUF606; Region: DUF606; pfam04657
696281000494	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
696281000495	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
696281000496	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
696281000497	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128
696281000498	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
696281000499	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
696281000500	Transcriptional regulators [Transcription]; Region: GntR; COG1802
696281000501	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
696281000502	DNA-binding site [nucleotide binding]; DNA binding site
696281000503	FCD domain; Region: FCD; pfam07729
696281000504	threonine dehydratase; Provisional; Region: PRK08198
696281000505	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
696281000506	tetramer interface [polypeptide binding]; other site
696281000507	pyridoxal 5'-phosphate binding site [chemical binding]; other site
696281000508	catalytic residue [active]
696281000509	C-terminal ACT domain of biodegradative (catabolic) threonine dehydratase II (ThrD-II) and other related ACT domains; Region: ACT_ThrD-II-like; cd04886
696281000510	regulatory protein SpoVG; Reviewed; Region: PRK13259
696281000511	bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354
696281000512	N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540
696281000513	Substrate binding site; other site
696281000514	Mg++ binding site; other site
696281000515	N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353
696281000516	active site
696281000517	substrate binding site [chemical binding]; other site
696281000518	CoA binding site [chemical binding]; other site
696281000519	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259
696281000520	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
696281000521	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
696281000522	active site
696281000523	Domain of unknown function DUF39; Region: DUF39; pfam01837
696281000524	This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930
696281000525	4Fe-4S binding domain; Region: Fer4; pfam00037
696281000526	hypothetical protein; Provisional; Region: PRK04334
696281000527	Uncharacterized family of ferritin-like proteins found in archaea and bacteria; Region: Ferritin_like_AB; cd01045
696281000528	diiron binding motif [ion binding]; other site
696281000529	PRC-barrel domain containing protein [General function prediction only]; Region: COG3881
696281000530	PRC-barrel domain; Region: PRC; pfam05239
696281000531	Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495
696281000532	ribosomal protein L25, Ctc-form; Region: ctc_TL5; TIGR00731
696281000533	5S rRNA interface [nucleotide binding]; other site
696281000534	CTC domain interface [polypeptide binding]; other site
696281000535	L16 interface [polypeptide binding]; other site
696281000536	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
696281000537	putative active site [active]
696281000538	catalytic residue [active]
696281000539	Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197
696281000540	CarD-like/TRCF domain; Region: CarD_TRCF; smart01058
696281000541	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
696281000542	ATP binding site [chemical binding]; other site
696281000543	putative Mg++ binding site [ion binding]; other site
696281000544	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
696281000545	nucleotide binding region [chemical binding]; other site
696281000546	ATP-binding site [chemical binding]; other site
696281000547	This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982
696281000548	peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059
696281000549	PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145
696281000550	stage V sporulation protein T; Region: spore_V_T; TIGR02851
696281000551	Antidote-toxin recognition MazE; Region: Antitoxin-MazE; pfam04014
696281000552	GAF domain; Region: GAF; pfam01590
696281000553	N-terminal S-AdoMet dependent methylase domain of Bacillus subtilis YabN and related proteins; Region: YabN_N; cd11723
696281000554	putative SAM binding site [chemical binding]; other site
696281000555	putative homodimer interface [polypeptide binding]; other site
696281000556	Protein containing tetrapyrrole methyltransferase domain and MazG-like (predicted pyrophosphatase) domain [General function prediction only]; Region: COG3956
696281000557	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528
696281000558	homodimer interface [polypeptide binding]; other site
696281000559	metal binding site [ion binding]; metal-binding site
696281000560	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529
696281000561	homodimer interface [polypeptide binding]; other site
696281000562	active site
696281000563	putative chemical substrate binding site [chemical binding]; other site
696281000564	metal binding site [ion binding]; metal-binding site
696281000565	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
696281000566	IHF dimer interface [polypeptide binding]; other site
696281000567	IHF - DNA interface [nucleotide binding]; other site
696281000568	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
696281000569	RNA binding surface [nucleotide binding]; other site
696281000570	Stage II sporulation protein; Region: SpoIID; pfam08486
696281000571	SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669
696281000572	HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078
696281000573	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
696281000574	Zn2+ binding site [ion binding]; other site
696281000575	Mg2+ binding site [ion binding]; other site
696281000576	Uncharacterized conserved protein [Function unknown]; Region: COG3465
696281000577	YabP family; Region: YabP; cl06766
696281000578	Spore cortex protein YabQ (Spore_YabQ); Region: Spore_YabQ; pfam09578
696281000579	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
696281000580	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
696281000581	Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919
696281000582	Septum formation initiator; Region: DivIC; pfam04977
696281000583	hypothetical protein; Provisional; Region: PRK08582
696281000584	S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692
696281000585	RNA binding site [nucleotide binding]; other site
696281000586	exopolyphosphatase; Region: exo_poly_only; TIGR03706
696281000587	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
696281000588	nucleotide binding site [chemical binding]; other site
696281000589	stage II sporulation protein E; Region: spore_II_E; TIGR02865
696281000590	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
696281000591	tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037
696281000592	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
696281000593	TilS substrate C-terminal domain; Region: TilS_C; smart00977
696281000594	FtsH Extracellular; Region: FtsH_ext; pfam06480
696281000595	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
696281000596	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
696281000597	Walker A motif; other site
696281000598	ATP binding site [chemical binding]; other site
696281000599	Walker B motif; other site
696281000600	arginine finger; other site
696281000601	Peptidase family M41; Region: Peptidase_M41; pfam01434
696281000602	Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413
696281000603	active site
696281000604	multimer interface [polypeptide binding]; other site
696281000605	Predicted thioesterase [General function prediction only]; Region: COG5496
696281000606	formate--tetrahydrofolate ligase; Provisional; Region: PRK13505
696281000607	Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477
696281000608	Potassium binding sites [ion binding]; other site
696281000609	Cesium cation binding sites [ion binding]; other site
696281000610	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
696281000611	Major Facilitator Superfamily; Region: MFS_1; pfam07690
696281000612	intracellular protease, PfpI family; Region: PfpI; TIGR01382
696281000613	A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134
696281000614	proposed catalytic triad [active]
696281000615	conserved cys residue [active]
696281000616	Heterodisulfide reductase, subunit A and related polyferredoxins [Energy production and conversion]; Region: HdrA; COG1148
696281000617	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
696281000618	4Fe-4S binding domain; Region: Fer4; pfam00037
696281000619	Heterodisulfide reductase, subunit A and related polyferredoxins [Energy production and conversion]; Region: HdrA; COG1148
696281000620	Heterodisulfide reductase, subunit A and related polyferredoxins [Energy production and conversion]; Region: HdrA; COG1148
696281000621	4Fe-4S binding domain; Region: Fer4; pfam00037
696281000622	Methyl-viologen-reducing hydrogenase, delta subunit; Region: FlpD; pfam02662
696281000623	Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus; Region: FrhB_FdhB_C; pfam04432
696281000624	4Fe-4S dicluster domain; Region: Fer4_18; pfam13746
696281000625	anaerobic sulfite reductase subunit A; Provisional; Region: PRK15055
696281000626	cytochrome-c3 hydrogenase subunit gamma; Provisional; Region: PRK08345
696281000627	Anaerobic sulfite reductase contains an FAD and NADPH binding module with structural similarity to ferredoxin reductase and sequence similarity to dihydroorotate dehydrogenases. Clostridium pasteurianum inducible dissimilatory type sulfite reductase is...; Region: sulfite_reductase_like; cd06221
696281000628	FAD binding pocket [chemical binding]; other site
696281000629	FAD binding motif [chemical binding]; other site
696281000630	phosphate binding motif [ion binding]; other site
696281000631	beta-alpha-beta structure motif; other site
696281000632	NAD binding pocket [chemical binding]; other site
696281000633	Iron coordination center [ion binding]; other site
696281000634	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
696281000635	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
696281000636	4Fe-4S binding domain; Region: Fer4; pfam00037
696281000637	4Fe-4S dicluster domain; Region: Fer4_9; pfam13187
696281000638	Heterodisulfide reductase, subunit A and related polyferredoxins [Energy production and conversion]; Region: HdrA; COG1148
696281000639	Heterodisulfide reductase, subunit A and related polyferredoxins [Energy production and conversion]; Region: HdrA; COG1148
696281000640	4Fe-4S binding domain; Region: Fer4; pfam00037
696281000641	Methyl-viologen-reducing hydrogenase, delta subunit; Region: FlpD; pfam02662
696281000642	Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus; Region: FrhB_FdhB_C; pfam04432
696281000643	4Fe-4S dicluster domain; Region: Fer4_18; pfam13746
696281000644	anaerobic sulfite reductase subunit A; Provisional; Region: PRK15055
696281000645	cytochrome-c3 hydrogenase subunit gamma; Provisional; Region: PRK08345
696281000646	Anaerobic sulfite reductase contains an FAD and NADPH binding module with structural similarity to ferredoxin reductase and sequence similarity to dihydroorotate dehydrogenases. Clostridium pasteurianum inducible dissimilatory type sulfite reductase is...; Region: sulfite_reductase_like; cd06221
696281000647	FAD binding pocket [chemical binding]; other site
696281000648	FAD binding motif [chemical binding]; other site
696281000649	phosphate binding motif [ion binding]; other site
696281000650	beta-alpha-beta structure motif; other site
696281000651	NAD binding pocket [chemical binding]; other site
696281000652	Iron coordination center [ion binding]; other site
696281000653	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
696281000654	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
696281000655	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
696281000656	substrate binding pocket [chemical binding]; other site
696281000657	membrane-bound complex binding site; other site
696281000658	hinge residues; other site
696281000659	Predicted membrane protein [Function unknown]; Region: COG3428
696281000660	Bacterial PH domain; Region: DUF304; cl01348
696281000661	Bacterial PH domain; Region: DUF304; pfam03703
696281000662	Bacterial PH domain; Region: DUF304; pfam03703
696281000663	Uncharacterized conserved protein [Function unknown]; Region: COG3402
696281000664	MarR family; Region: MarR; pfam01047
696281000665	Putative cyclase; Region: Cyclase; cl00814
696281000666	ATP-utilizing enzymes of the PP-loop superfamily [General function prediction only]; Region: COG1606
696281000667	This is a subfamily of Adenine nucleotide alpha hydrolases superfamily. Adenine nucleotide alpha hydrolases superfamily  includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which  binds to Adenosine group.  This subfamily; Region: Alpha_ANH_like_I; cd01990
696281000668	Ligand Binding Site [chemical binding]; other site
696281000669	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
696281000670	CoenzymeA binding site [chemical binding]; other site
696281000671	subunit interaction site [polypeptide binding]; other site
696281000672	PHB binding site; other site
696281000673	NAD(P)H:flavin oxidoreductase-like family 1.  A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes; Region: NADPH_oxidoreductase_1; cd02150
696281000674	putative FMN binding site [chemical binding]; other site
696281000675	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
696281000676	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
696281000677	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
696281000678	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
696281000679	dihydropteroate synthase; Region: DHPS; TIGR01496
696281000680	substrate binding pocket [chemical binding]; other site
696281000681	dimer interface [polypeptide binding]; other site
696281000682	inhibitor binding site; inhibition site
696281000683	Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534
696281000684	homooctamer interface [polypeptide binding]; other site
696281000685	active site
696281000686	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
696281000687	catalytic center binding site [active]
696281000688	ATP binding site [chemical binding]; other site
696281000689	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
696281000690	tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617
696281000691	active site
696281000692	NTP binding site [chemical binding]; other site
696281000693	metal binding triad [ion binding]; metal-binding site
696281000694	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
696281000695	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
696281000696	Zn2+ binding site [ion binding]; other site
696281000697	Mg2+ binding site [ion binding]; other site
696281000698	Protein of unknown function (DUF1648); Region: DUF1648; pfam07853
696281000699	Uncharacterized conserved protein [Function unknown]; Region: COG5495
696281000700	Rossmann-like domain; Region: Rossmann-like; pfam10727
696281000701	Domain of unknown function (DUF2520); Region: DUF2520; pfam10728
696281000702	Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557
696281000703	oligomerization interface [polypeptide binding]; other site
696281000704	active site
696281000705	metal binding site [ion binding]; metal-binding site
696281000706	pantoate--beta-alanine ligase; Region: panC; TIGR00018
696281000707	Pantoate-beta-alanine ligase; Region: PanC; cd00560
696281000708	active site
696281000709	ATP-binding site [chemical binding]; other site
696281000710	pantoate-binding site; other site
696281000711	HXXH motif; other site
696281000712	Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent  decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919
696281000713	tetramerization interface [polypeptide binding]; other site
696281000714	active site
696281000715	Quinolinate synthetase A protein; Region: NadA; pfam02445
696281000716	Aspartate oxidase [Coenzyme metabolism]; Region: NadB; COG0029
696281000717	L-aspartate oxidase; Provisional; Region: PRK06175
696281000718	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
696281000719	Nicotinate-nucleotide pyrophosphorylase [Coenzyme metabolism]; Region: NadC; COG0157
696281000720	Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572
696281000721	dimerization interface [polypeptide binding]; other site
696281000722	active site
696281000723	biotin synthase; Region: bioB; TIGR00433
696281000724	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
696281000725	FeS/SAM binding site; other site
696281000726	Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968
696281000727	Biotin operon repressor [Transcription]; Region: BirA; COG1654
696281000728	Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340
696281000729	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057
696281000730	Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237
696281000731	BioY family; Region: BioY; pfam02632
696281000732	putative beta-lysine N-acetyltransferase; Region: GNAT_ablB; TIGR03827
696281000733	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
696281000734	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
696281000735	Nitrite and sulphite reductase 4Fe-4S domain; Region: NIR_SIR; pfam01077
696281000736	pantothenate kinase; Reviewed; Region: PRK13318
696281000737	putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737
696281000738	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
696281000739	FMN binding site [chemical binding]; other site
696281000740	active site
696281000741	catalytic residues [active]
696281000742	substrate binding site [chemical binding]; other site
696281000743	NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226
696281000744	NAD(P) binding pocket [chemical binding]; other site
696281000745	Uncharacterized conserved protein, YhbC family [Function unknown]; Region: COG0782
696281000746	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
696281000747	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
696281000748	lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484
696281000749	LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322
696281000750	dimer interface [polypeptide binding]; other site
696281000751	putative anticodon binding site; other site
696281000752	Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775
696281000753	motif 1; other site
696281000754	active site
696281000755	motif 2; other site
696281000756	motif 3; other site
696281000757	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
696281000758	Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234
696281000759	nucleotide binding site [chemical binding]; other site
696281000760	NEF interaction site [polypeptide binding]; other site
696281000761	SBD interface [polypeptide binding]; other site
696281000762	chaperone protein DnaJ; Region: DnaJ_bact; TIGR02349
696281000763	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
696281000764	HSP70 interaction site [polypeptide binding]; other site
696281000765	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
696281000766	substrate binding site [polypeptide binding]; other site
696281000767	dimer interface [polypeptide binding]; other site
696281000768	chaperone-modulator protein CbpM; Provisional; Region: PRK10265
696281000769	MerR HTH family regulatory protein; Region: MerR_2; pfam13591
696281000770	ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346
696281000771	Clp amino terminal domain; Region: Clp_N; pfam02861
696281000772	Clp amino terminal domain; Region: Clp_N; pfam02861
696281000773	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
696281000774	Walker A motif; other site
696281000775	ATP binding site [chemical binding]; other site
696281000776	Walker B motif; other site
696281000777	arginine finger; other site
696281000778	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
696281000779	Walker A motif; other site
696281000780	ATP binding site [chemical binding]; other site
696281000781	Walker B motif; other site
696281000782	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
696281000783	Firmicute transcriptional repressor of class III stress genes (CtsR); Region: CtsR; pfam05848
696281000784	Modulator of heat shock repressor CtsR, McsA [Signal transduction    mechanisms]; Region: COG3880
696281000785	UvrB/uvrC motif; Region: UVR; pfam02151
696281000786	ATP:guanido phosphotransferase; Provisional; Region: PRK01059
696281000787	Phosphagen (guanidino) kinases found in bacteria; Region: bacterial_phosphagen_kinase; cd07930
696281000788	ADP binding site [chemical binding]; other site
696281000789	phosphagen binding site; other site
696281000790	substrate specificity loop; other site
696281000791	Clp protease ATP binding subunit; Region: clpC; CHL00095
696281000792	Clp amino terminal domain; Region: Clp_N; pfam02861
696281000793	Clp amino terminal domain; Region: Clp_N; pfam02861
696281000794	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
696281000795	Walker A motif; other site
696281000796	ATP binding site [chemical binding]; other site
696281000797	Walker B motif; other site
696281000798	arginine finger; other site
696281000799	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
696281000800	Walker A motif; other site
696281000801	ATP binding site [chemical binding]; other site
696281000802	Walker B motif; other site
696281000803	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
696281000804	DNA repair protein RadA; Provisional; Region: PRK11823
696281000805	Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121
696281000806	Walker A motif/ATP binding site; other site
696281000807	ATP binding site [chemical binding]; other site
696281000808	Walker B motif; other site
696281000809	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
696281000810	DNA integrity scanning protein DisA; Provisional; Region: PRK13482
696281000811	DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457
696281000812	DisA bacterial checkpoint controller linker region; Region: DisA-linker; pfam10635
696281000813	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cl16941
696281000814	Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329
696281000815	Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956
696281000816	PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877
696281000817	putative active site [active]
696281000818	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
696281000819	substrate binding site; other site
696281000820	dimer interface; other site
696281000821	MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554
696281000822	homotrimer interaction site [polypeptide binding]; other site
696281000823	zinc binding site [ion binding]; other site
696281000824	CDP-binding sites; other site
696281000825	glutaminyl-tRNA synthetase; Provisional; Region: PRK05347
696281000826	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
696281000827	active site
696281000828	HIGH motif; other site
696281000829	nucleotide binding site [chemical binding]; other site
696281000830	catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807
696281000831	KMSKS motif; other site
696281000832	tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950
696281000833	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
696281000834	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
696281000835	active site
696281000836	HIGH motif; other site
696281000837	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
696281000838	active site
696281000839	KMSKS motif; other site
696281000840	Serine acetyltransferase [Amino acid transport and metabolism]; Region: CysE; COG1045
696281000841	Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762
696281000842	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
696281000843	trimer interface [polypeptide binding]; other site
696281000844	active site
696281000845	substrate binding site [chemical binding]; other site
696281000846	CoA binding site [chemical binding]; other site
696281000847	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
696281000848	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
696281000849	active site
696281000850	HIGH motif; other site
696281000851	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
696281000852	KMSKS motif; other site
696281000853	Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963
696281000854	tRNA binding surface [nucleotide binding]; other site
696281000855	anticodon binding site; other site
696281000856	Ribonuclease III family protein [Replication, recombination, and    repair]; Region: COG1939
696281000857	active site
696281000858	metal binding site [ion binding]; metal-binding site
696281000859	dimerization interface [polypeptide binding]; other site
696281000860	FAD-dependent thymidylate synthase; Reviewed; Region: thyX; PRK00847
696281000861	rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186
696281000862	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967
696281000863	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
696281000864	YacP-like NYN domain; Region: NYN_YacP; pfam05991
696281000865	RNA polymerase factor sigma-70; Validated; Region: PRK08295
696281000866	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
696281000867	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
696281000868	elongation factor Tu; Reviewed; Region: PRK00049
696281000869	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
696281000870	G1 box; other site
696281000871	GEF interaction site [polypeptide binding]; other site
696281000872	GTP/Mg2+ binding site [chemical binding]; other site
696281000873	Switch I region; other site
696281000874	G2 box; other site
696281000875	G3 box; other site
696281000876	Switch II region; other site
696281000877	G4 box; other site
696281000878	G5 box; other site
696281000879	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
696281000880	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
696281000881	Antibiotic Binding Site [chemical binding]; other site
696281000882	50S ribosomal protein L33; Validated; Region: rpmG; PRK00504
696281000883	SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; pfam00584
696281000884	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
696281000885	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
696281000886	putative homodimer interface [polypeptide binding]; other site
696281000887	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
696281000888	heterodimer interface [polypeptide binding]; other site
696281000889	homodimer interface [polypeptide binding]; other site
696281000890	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
696281000891	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
696281000892	23S rRNA interface [nucleotide binding]; other site
696281000893	L7/L12 interface [polypeptide binding]; other site
696281000894	putative thiostrepton binding site; other site
696281000895	L25 interface [polypeptide binding]; other site
696281000896	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
696281000897	mRNA/rRNA interface [nucleotide binding]; other site
696281000898	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
696281000899	23S rRNA interface [nucleotide binding]; other site
696281000900	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
696281000901	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
696281000902	peripheral dimer interface [polypeptide binding]; other site
696281000903	core dimer interface [polypeptide binding]; other site
696281000904	L10 interface [polypeptide binding]; other site
696281000905	L11 interface [polypeptide binding]; other site
696281000906	putative EF-Tu interaction site [polypeptide binding]; other site
696281000907	putative EF-G interaction site [polypeptide binding]; other site
696281000908	DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405
696281000909	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
696281000910	RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561
696281000911	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
696281000912	RPB1 interaction site [polypeptide binding]; other site
696281000913	RPB10 interaction site [polypeptide binding]; other site
696281000914	RPB11 interaction site [polypeptide binding]; other site
696281000915	RPB3 interaction site [polypeptide binding]; other site
696281000916	RPB12 interaction site [polypeptide binding]; other site
696281000917	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
696281000918	DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566
696281000919	RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663
696281000920	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
696281000921	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
696281000922	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
696281000923	Rpb1 - Rpb6 interaction site [polypeptide binding]; other site
696281000924	Apocytochrome F, C-terminal; Region: Apocytochr_F_C; cl03168
696281000925	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
696281000926	DNA binding site [nucleotide binding]
696281000927	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
696281000928	putative ribosomal protein L7Ae-like; Provisional; Region: PRK13602
696281000929	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
696281000930	S17 interaction site [polypeptide binding]; other site
696281000931	S8 interaction site; other site
696281000932	16S rRNA interaction site [nucleotide binding]; other site
696281000933	streptomycin interaction site [chemical binding]; other site
696281000934	23S rRNA interaction site [nucleotide binding]; other site
696281000935	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
696281000936	30S ribosomal protein S7; Validated; Region: PRK05302
696281000937	elongation factor G; Reviewed; Region: PRK00007
696281000938	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
696281000939	G1 box; other site
696281000940	putative GEF interaction site [polypeptide binding]; other site
696281000941	GTP/Mg2+ binding site [chemical binding]; other site
696281000942	Switch I region; other site
696281000943	G2 box; other site
696281000944	G3 box; other site
696281000945	Switch II region; other site
696281000946	G4 box; other site
696281000947	G5 box; other site
696281000948	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
696281000949	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
696281000950	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
696281000951	elongation factor Tu; Reviewed; Region: PRK00049
696281000952	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
696281000953	G1 box; other site
696281000954	GEF interaction site [polypeptide binding]; other site
696281000955	GTP/Mg2+ binding site [chemical binding]; other site
696281000956	Switch I region; other site
696281000957	G2 box; other site
696281000958	G3 box; other site
696281000959	Switch II region; other site
696281000960	G4 box; other site
696281000961	G5 box; other site
696281000962	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
696281000963	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
696281000964	Antibiotic Binding Site [chemical binding]; other site
696281000965	30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596
696281000966	50S ribosomal protein L3; Validated; Region: rplC; PRK00001
696281000967	50S ribosomal protein L4; Provisional; Region: rplD; PRK05319
696281000968	50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738
696281000969	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
696281000970	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
696281000971	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
696281000972	30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357
696281000973	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
696281000974	putative translocon binding site; other site
696281000975	protein-rRNA interface [nucleotide binding]; other site
696281000976	30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310
696281000977	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
696281000978	G-X-X-G motif; other site
696281000979	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
696281000980	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
696281000981	23S rRNA interface [nucleotide binding]; other site
696281000982	5S rRNA interface [nucleotide binding]; other site
696281000983	putative antibiotic binding site [chemical binding]; other site
696281000984	L25 interface [polypeptide binding]; other site
696281000985	L27 interface [polypeptide binding]; other site
696281000986	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427
696281000987	23S rRNA interface [nucleotide binding]; other site
696281000988	putative translocon interaction site; other site
696281000989	signal recognition particle (SRP54) interaction site; other site
696281000990	L23 interface [polypeptide binding]; other site
696281000991	trigger factor interaction site; other site
696281000992	30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610
696281000993	50S ribosomal protein L14; Validated; Region: rplN; PRK05483
696281000994	50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004
696281000995	KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089
696281000996	RNA binding site [nucleotide binding]; other site
696281000997	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
696281000998	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
696281000999	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
696281001000	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061
696281001001	30S ribosomal protein S8; Validated; Region: rpsH; PRK00136
696281001002	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
696281001003	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
696281001004	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
696281001005	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
696281001006	23S rRNA interface [nucleotide binding]; other site
696281001007	5S rRNA interface [nucleotide binding]; other site
696281001008	L27 interface [polypeptide binding]; other site
696281001009	L5 interface [polypeptide binding]; other site
696281001010	30S ribosomal protein S5; Validated; Region: rpsE; PRK00550
696281001011	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
696281001012	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
696281001013	Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658
696281001014	23S rRNA binding site [nucleotide binding]; other site
696281001015	50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592
696281001016	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
696281001017	SecY translocase; Region: SecY; pfam00344
696281001018	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
696281001019	active site
696281001020	KOW motif of Ribosomal Protein L14; Region: KOW_RPL14; cd06088
696281001021	RNA binding site [nucleotide binding]; other site
696281001022	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
696281001023	rRNA binding site [nucleotide binding]; other site
696281001024	predicted 30S ribosome binding site; other site
696281001025	50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465
696281001026	30S ribosomal protein S13; Validated; Region: rpsM; PRK05179
696281001027	30S ribosomal protein S13; Region: bact_S13; TIGR03631
696281001028	30S ribosomal protein S11; Validated; Region: PRK05309
696281001029	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
696281001030	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
696281001031	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
696281001032	RNA binding surface [nucleotide binding]; other site
696281001033	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
696281001034	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
696281001035	alphaNTD homodimer interface [polypeptide binding]; other site
696281001036	alphaNTD - beta interaction site [polypeptide binding]; other site
696281001037	alphaNTD - beta' interaction site [polypeptide binding]; other site
696281001038	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
696281001039	50S ribosomal protein L17; Validated; Region: rplQ; PRK05591
696281001040	cobalt transporter ATP-binding subunit; Provisional; Region: PRK13633
696281001041	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
696281001042	Walker A/P-loop; other site
696281001043	ATP binding site [chemical binding]; other site
696281001044	Q-loop/lid; other site
696281001045	ABC transporter signature motif; other site
696281001046	Walker B; other site
696281001047	D-loop; other site
696281001048	H-loop/switch region; other site
696281001049	cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13637
696281001050	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
696281001051	Walker A/P-loop; other site
696281001052	ATP binding site [chemical binding]; other site
696281001053	Q-loop/lid; other site
696281001054	ABC transporter signature motif; other site
696281001055	Walker B; other site
696281001056	D-loop; other site
696281001057	H-loop/switch region; other site
696281001058	ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619
696281001059	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
696281001060	Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA; Region: PseudoU_synth_EcTruA; cd02570
696281001061	dimerization interface 3.5A [polypeptide binding]; other site
696281001062	active site
696281001063	xanthine permease; Region: pbuX; TIGR03173
696281001064	S-layer homology domain; Region: SLH; pfam00395
696281001065	S-layer homology domain; Region: SLH; pfam00395
696281001066	S-layer homology domain; Region: SLH; pfam00395
696281001067	Holin family; Region: Phage_holin_4; pfam05105
696281001068	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
696281001069	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
696281001070	DNA binding residues [nucleotide binding]
696281001071	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
696281001072	23S rRNA interface [nucleotide binding]; other site
696281001073	L3 interface [polypeptide binding]; other site
696281001074	30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132
696281001075	ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389
696281001076	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
696281001077	ATP binding site [chemical binding]; other site
696281001078	putative Mg++ binding site [ion binding]; other site
696281001079	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
696281001080	nucleotide binding region [chemical binding]; other site
696281001081	ATP-binding site [chemical binding]; other site
696281001082	This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956
696281001083	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4955
696281001084	HRDC domain; Region: HRDC; pfam00570
696281001085	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
696281001086	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
696281001087	active site
696281001088	metal binding site [ion binding]; metal-binding site
696281001089	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
696281001090	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
696281001091	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
696281001092	catalytic residue [active]
696281001093	Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822
696281001094	hypothetical protein; Provisional; Region: PRK03881
696281001095	The N-terminal domain, an extradiol dioxygenase class III subunit B-like domain, of unknown proteins containing a C-terminal AMMECR1 domain; Region: ED_3B_N_AMMECR1; cd07951
696281001096	AMMECR1; Region: AMMECR1; pfam01871
696281001097	AmmeMemoRadiSam system radical SAM enzyme; Region: AmmeMemoSam_rS; TIGR04337
696281001098	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
696281001099	FeS/SAM binding site; other site
696281001100	N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436
696281001101	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
696281001102	Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152
696281001103	heterotetramer interface [polypeptide binding]; other site
696281001104	active site pocket [active]
696281001105	cleavage site
696281001106	AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250
696281001107	feedback inhibition sensing region; other site
696281001108	homohexameric interface [polypeptide binding]; other site
696281001109	nucleotide binding site [chemical binding]; other site
696281001110	N-acetyl-L-glutamate binding site [chemical binding]; other site
696281001111	acetylornithine aminotransferase; Provisional; Region: PRK02627
696281001112	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
696281001113	inhibitor-cofactor binding pocket; inhibition site
696281001114	pyridoxal 5'-phosphate binding site [chemical binding]; other site
696281001115	catalytic residue [active]
696281001116	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
696281001117	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
696281001118	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
696281001119	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
696281001120	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
696281001121	ATP-grasp domain; Region: ATP-grasp_4; cl17255
696281001122	MGS-like domain. This domain composes the whole protein of methylglyoxal synthetase, which catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The family also includes the C-terminal domain in carbamoyl phosphate...; Region: MGS-like; cl00245
696281001123	substrate binding site [chemical binding]; other site
696281001124	ornithine carbamoyltransferase; Provisional; Region: PRK00779
696281001125	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
696281001126	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
696281001127	argininosuccinate synthase; Provisional; Region: PRK13820
696281001128	Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate .  In...; Region: Argininosuccinate_Synthase; cd01999
696281001129	ANP binding site [chemical binding]; other site
696281001130	Substrate Binding Site II [chemical binding]; other site
696281001131	Substrate Binding Site I [chemical binding]; other site
696281001132	argininosuccinate lyase; Provisional; Region: PRK00855
696281001133	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
696281001134	active sites [active]
696281001135	tetramer interface [polypeptide binding]; other site
696281001136	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
696281001137	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
696281001138	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
696281001139	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
696281001140	Zn2+ binding site [ion binding]; other site
696281001141	Mg2+ binding site [ion binding]; other site
696281001142	dihydroxy-acid dehydratase; Provisional; Region: PRK00911
696281001143	acetolactate synthase, large subunit, biosynthetic type; Region: acolac_lg; TIGR00118
696281001144	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
696281001145	PYR/PP interface [polypeptide binding]; other site
696281001146	dimer interface [polypeptide binding]; other site
696281001147	TPP binding site [chemical binding]; other site
696281001148	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
696281001149	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
696281001150	TPP-binding site [chemical binding]; other site
696281001151	dimer interface [polypeptide binding]; other site
696281001152	acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895
696281001153	N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878
696281001154	putative valine binding site [chemical binding]; other site
696281001155	dimer interface [polypeptide binding]; other site
696281001156	Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369
696281001157	ketol-acid reductoisomerase; Provisional; Region: PRK05479
696281001158	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991
696281001159	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
696281001160	acetolactate synthase, large subunit, biosynthetic type; Region: acolac_lg; TIGR00118
696281001161	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
696281001162	PYR/PP interface [polypeptide binding]; other site
696281001163	dimer interface [polypeptide binding]; other site
696281001164	TPP binding site [chemical binding]; other site
696281001165	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cd00368
696281001166	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
696281001167	TPP-binding site [chemical binding]; other site
696281001168	dimer interface [polypeptide binding]; other site
696281001169	2-isopropylmalate synthase; Validated; Region: PRK00915
696281001170	2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940
696281001171	active site
696281001172	catalytic residues [active]
696281001173	metal binding site [ion binding]; metal-binding site
696281001174	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502
696281001175	3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
696281001176	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
696281001177	substrate binding site [chemical binding]; other site
696281001178	ligand binding site [chemical binding]; other site
696281001179	3-isopropylmalate dehydratase small subunit; Reviewed; Region: leuD; PRK00439
696281001180	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
696281001181	substrate binding site [chemical binding]; other site
696281001182	3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772
696281001183	tartrate dehydrogenase; Region: TTC; TIGR02089
696281001184	putative alpha-isopropylmalate/homocitrate synthase family transferase; Provisional; Region: PRK12344
696281001185	Desulfobacterium autotrophicum LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA3; cd07941
696281001186	active site
696281001187	catalytic residues [active]
696281001188	metal binding site [ion binding]; metal-binding site
696281001189	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917
696281001190	Uncharacterized conserved protein [Function unknown]; Region: COG1624
696281001191	DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457
696281001192	YbbR-like protein; Region: YbbR; pfam07949
696281001193	YbbR-like protein; Region: YbbR; pfam07949
696281001194	phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316
696281001195	GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802
696281001196	active site
696281001197	substrate binding site [chemical binding]; other site
696281001198	metal binding site [ion binding]; metal-binding site
696281001199	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
696281001200	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
696281001201	glutaminase active site [active]
696281001202	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
696281001203	dimer interface [polypeptide binding]; other site
696281001204	active site
696281001205	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
696281001206	dimer interface [polypeptide binding]; other site
696281001207	active site
696281001208	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
696281001209	DNA methylase; Region: N6_N4_Mtase; pfam01555
696281001210	Restriction endonuclease BglII; Region: Endonuc-BglII; pfam09195
696281001211	Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553
696281001212	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
696281001213	ATP binding site [chemical binding]; other site
696281001214	putative Mg++ binding site [ion binding]; other site
696281001215	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
696281001216	nucleotide binding region [chemical binding]; other site
696281001217	ATP-binding site [chemical binding]; other site
696281001218	Domain of unknown function (DUF3883); Region: DUF3883; pfam13020
696281001219	Rubredoxin, Small Modular nonheme iron binding domain containing a [Fe(SCys)4] center, present in rubrerythrin and nigerythrin and detected either N- or C-terminal to such proteins as flavin reductase, NAD(P)H-nitrite reductase, and...; Region: rubredoxin_SM; cd00729
696281001220	iron binding site [ion binding]; other site
696281001221	Rubrerythrin [Energy production and conversion]; Region: COG1592
696281001222	rubrerythrin-like, diiron-binding domain; Region: Rubrerythrin_like; cd01046
696281001223	diiron binding motif [ion binding]; other site
696281001224	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
696281001225	metal binding site 2 [ion binding]; metal-binding site
696281001226	putative DNA binding helix; other site
696281001227	metal binding site 1 [ion binding]; metal-binding site
696281001228	dimer interface [polypeptide binding]; other site
696281001229	structural Zn2+ binding site [ion binding]; other site
696281001230	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
696281001231	dimerization interface [polypeptide binding]; other site
696281001232	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
696281001233	dimer interface [polypeptide binding]; other site
696281001234	Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015
696281001235	putative CheW interface [polypeptide binding]; other site
696281001236	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
696281001237	2-phosphosulpholactate phosphatase; Region: 2-ph_phosp; pfam04029
696281001238	Phosphosulfolactate phosphohydrolase and related enzymes [Coenzyme metabolism / General function prediction only]; Region: COG2045
696281001239	sulfite reductase, dissimilatory-type beta subunit; Region: dsrB; TIGR02066
696281001240	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
696281001241	sulfite reductase, dissimilatory-type alpha subunit; Region: dsrA; TIGR02064
696281001242	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
696281001243	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
696281001244	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
696281001245	DNA-binding site [nucleotide binding]; DNA binding site
696281001246	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
696281001247	pyridoxal 5'-phosphate binding site [chemical binding]; other site
696281001248	homodimer interface [polypeptide binding]; other site
696281001249	catalytic residue [active]
696281001250	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
696281001251	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
696281001252	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
696281001253	NAD(P)H:flavin oxidoreductase-like family 1.  A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes; Region: NADPH_oxidoreductase_1; cd02150
696281001254	putative FMN binding site [chemical binding]; other site
696281001255	Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385
696281001256	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
696281001257	putative active site [active]
696281001258	putative metal binding site [ion binding]; other site
696281001259	RNA polymerase sigma-70 factor, TIGR02954 family; Region: Sig70_famx3
696281001260	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
696281001261	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
696281001262	DNA binding residues [nucleotide binding]
696281001263	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
696281001264	salt bridge; other site
696281001265	non-specific DNA binding site [nucleotide binding]; other site
696281001266	sequence-specific DNA binding site [nucleotide binding]; other site
696281001267	Protein of unknown function (DUF3036); Region: DUF3036; pfam11234
696281001268	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
696281001269	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
696281001270	non-specific DNA binding site [nucleotide binding]; other site
696281001271	salt bridge; other site
696281001272	sequence-specific DNA binding site [nucleotide binding]; other site
696281001273	Cupin domain; Region: Cupin_2; pfam07883
696281001274	AzlC protein; Region: AzlC; cl00570
696281001275	Branched-chain amino acid transport protein (AzlD); Region: AzlD; pfam05437
696281001276	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587
696281001277	ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496
696281001278	ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496
696281001279	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587
696281001280	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4586
696281001281	ATP-binding cassette domain of an uncharacterized transporter similar in sequence to NatA; Region: ABC_NatA_like; cd03267
696281001282	Walker A/P-loop; other site
696281001283	ATP binding site [chemical binding]; other site
696281001284	Q-loop/lid; other site
696281001285	ABC transporter signature motif; other site
696281001286	Walker B; other site
696281001287	D-loop; other site
696281001288	H-loop/switch region; other site
696281001289	Domain of unknown function (DUF4162); Region: DUF4162; pfam13732
696281001290	1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080
696281001291	UbiA prenyltransferase family; Region: UbiA; pfam01040
696281001292	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
696281001293	heavy metal response regulator; Region: cztR_silR_copR; TIGR01387
696281001294	active site
696281001295	phosphorylation site [posttranslational modification]
696281001296	intermolecular recognition site; other site
696281001297	dimerization interface [polypeptide binding]; other site
696281001298	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
696281001299	DNA binding site [nucleotide binding]
696281001300	heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386
696281001301	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
696281001302	dimerization interface [polypeptide binding]; other site
696281001303	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
696281001304	dimer interface [polypeptide binding]; other site
696281001305	phosphorylation site [posttranslational modification]
696281001306	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
696281001307	ATP binding site [chemical binding]; other site
696281001308	Mg2+ binding site [ion binding]; other site
696281001309	G-X-G motif; other site
696281001310	Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506
696281001311	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
696281001312	catalytic residues [active]
696281001313	Cache domain; Region: Cache_1; pfam02743
696281001314	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
696281001315	dimerization interface [polypeptide binding]; other site
696281001316	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
696281001317	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
696281001318	dimer interface [polypeptide binding]; other site
696281001319	putative CheW interface [polypeptide binding]; other site
696281001320	benzoate transport; Region: 2A0115; TIGR00895
696281001321	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
696281001322	putative substrate translocation pore; other site
696281001323	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
696281001324	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
696281001325	EamA-like transporter family; Region: EamA; pfam00892
696281001326	EamA-like transporter family; Region: EamA; pfam00892
696281001327	Transcriptional regulator [Transcription]; Region: LysR; COG0583
696281001328	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
696281001329	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
696281001330	dimerization interface [polypeptide binding]; other site
696281001331	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
696281001332	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
696281001333	non-specific DNA binding site [nucleotide binding]; other site
696281001334	salt bridge; other site
696281001335	sequence-specific DNA binding site [nucleotide binding]; other site
696281001336	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
696281001337	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
696281001338	dimer interface [polypeptide binding]; other site
696281001339	putative functional site; other site
696281001340	putative MPT binding site; other site
696281001341	Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116
696281001342	Walker A motif; other site
696281001343	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
696281001344	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
696281001345	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
696281001346	Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792
696281001347	molybdopterin cofactor binding site; other site
696281001348	DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951
696281001349	Catalase-like heme-binding proteins and protein domains; Region: catalase_like; cl09506
696281001350	Polysulphide reductase [Energy production and conversion]; Region: COG5557; cl17901
696281001351	Polysulphide reductase, NrfD; Region: NrfD; pfam03916
696281001352	formate dehydrogenase accessory protein FdhE; Region: FdhE; TIGR01562
696281001353	Protein involved in formate dehydrogenase formation; Region: FdhE; pfam04216
696281001354	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
696281001355	Major Facilitator Superfamily; Region: MFS_1; pfam07690
696281001356	putative substrate translocation pore; other site
696281001357	Uncharacterized conserved protein (DUF2196); Region: DUF2196; pfam09962
696281001358	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
696281001359	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
696281001360	BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271
696281001361	Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) [Lipid metabolism]; Region: COG1924
696281001362	BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271
696281001363	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3580
696281001364	2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050
696281001365	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3581
696281001366	Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cl15837
696281001367	dimer interface [polypeptide binding]; other site
696281001368	Alkaline phosphatase homologues; Region: alkPPc; smart00098
696281001369	active site
696281001370	Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cl15837
696281001371	H+ Antiporter protein; Region: 2A0121; TIGR00900
696281001372	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
696281001373	putative substrate translocation pore; other site
696281001374	SirA_like_N, a protein of unknown function with an N-terminal SirA-like domain.  The SirA, YedF, YeeD protein family is present in bacteria as well as archaea. SirA (also known as UvrY,  and YhhP) belongs to a family of a two-component response...; Region: SirA_like_N; cd03421
696281001375	CPxP  motif; other site
696281001376	putative selenium metabolism protein, YedE family; Region: seleno_YedE; TIGR04112
696281001377	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
696281001378	Radical SAM superfamily; Region: Radical_SAM; pfam04055
696281001379	FeS/SAM binding site; other site
696281001380	Coproporphyrinogen III oxidase and related Fe-S oxidoreductases [Coenzyme metabolism]; Region: HemN; COG0635
696281001381	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
696281001382	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
696281001383	non-specific DNA binding site [nucleotide binding]; other site
696281001384	salt bridge; other site
696281001385	sequence-specific DNA binding site [nucleotide binding]; other site
696281001386	M20 Peptidase Arginine utilization protein, RocB; Region: M20_ArgE_RocB; cd05654
696281001387	putative metal binding site [ion binding]; other site
696281001388	putative dimer interface [polypeptide binding]; other site
696281001389	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
696281001390	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
696281001391	substrate binding pocket [chemical binding]; other site
696281001392	membrane-bound complex binding site; other site
696281001393	hinge residues; other site
696281001394	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
696281001395	dimer interface [polypeptide binding]; other site
696281001396	conserved gate region; other site
696281001397	putative PBP binding loops; other site
696281001398	ABC-ATPase subunit interface; other site
696281001399	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
696281001400	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
696281001401	Walker A/P-loop; other site
696281001402	ATP binding site [chemical binding]; other site
696281001403	Q-loop/lid; other site
696281001404	ABC transporter signature motif; other site
696281001405	Walker B; other site
696281001406	D-loop; other site
696281001407	H-loop/switch region; other site
696281001408	Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707
696281001409	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
696281001410	active site
696281001411	phosphorylation site [posttranslational modification]
696281001412	intermolecular recognition site; other site
696281001413	dimerization interface [polypeptide binding]; other site
696281001414	ANTAR domain; Region: ANTAR; pfam03861
696281001415	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
696281001416	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
696281001417	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
696281001418	Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069
696281001419	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
696281001420	active site
696281001421	FMN binding site [chemical binding]; other site
696281001422	substrate binding site [chemical binding]; other site
696281001423	3Fe-4S cluster binding site [ion binding]; other site
696281001424	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
696281001425	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
696281001426	dimer interface [polypeptide binding]; other site
696281001427	pyridoxal 5'-phosphate binding site [chemical binding]; other site
696281001428	catalytic residue [active]
696281001429	This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens  ProX Ala-tRNA(Pro)...; Region: ProX_deacylase; cd04333
696281001430	putative deacylase active site [active]
696281001431	This model contains proteins with the VRR-NUC domain; Region: VRR_NUC; smart00990
696281001432	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
696281001433	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
696281001434	Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989
696281001435	Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750
696281001436	Type IV leader peptidase family; Region: Peptidase_A24; pfam01478
696281001437	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544
696281001438	Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165
696281001439	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544
696281001440	Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165
696281001441	Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805
696281001442	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
696281001443	ATP binding site [chemical binding]; other site
696281001444	Walker B motif; other site
696281001445	Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157
696281001446	Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804
696281001447	PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129
696281001448	Walker A motif; other site
696281001449	ATP binding site [chemical binding]; other site
696281001450	Walker B motif; other site
696281001451	Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459
696281001452	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
696281001453	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
696281001454	Predicted ATPase [General function prediction only]; Region: COG3910
696281001455	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
696281001456	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
696281001457	Walker A/P-loop; other site
696281001458	Walker A/P-loop; other site
696281001459	ATP binding site [chemical binding]; other site
696281001460	ATP binding site [chemical binding]; other site
696281001461	Q-loop/lid; other site
696281001462	ABC transporter signature motif; other site
696281001463	Walker B; other site
696281001464	D-loop; other site
696281001465	H-loop/switch region; other site
696281001466	Iron-containing alcohol dehydrogenase; Region: Fe-ADH8; cd08186
696281001467	Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465
696281001468	putative active site [active]
696281001469	metal binding site [ion binding]; metal-binding site
696281001470	Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159
696281001471	active site
696281001472	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
696281001473	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
696281001474	DNA-binding site [nucleotide binding]; DNA binding site
696281001475	UTRA domain; Region: UTRA; pfam07702
696281001476	metabolite-proton symporter; Region: 2A0106; TIGR00883
696281001477	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
696281001478	putative substrate translocation pore; other site
696281001479	glycyl radical enzyme, PFL2/glycerol dehydratase family; Region: PFL2-3; TIGR01774
696281001480	Pyruvate formate lyase 2 and related enzymes; Region: PFL2_DhaB_BssA; cd01677
696281001481	dimer interface [polypeptide binding]; other site
696281001482	active site
696281001483	glycine loop; other site
696281001484	glycyl-radical enzyme activating protein family; Region: PFLE_PFLC; TIGR02494
696281001485	4Fe-4S binding domain; Region: Fer4; pfam00037
696281001486	DsrE/DsrF-like family; Region: DrsE; cl00672
696281001487	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
696281001488	Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385
696281001489	Sodium Bile acid symporter family; Region: SBF; cl17470
696281001490	heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386
696281001491	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
696281001492	dimerization interface [polypeptide binding]; other site
696281001493	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
696281001494	dimer interface [polypeptide binding]; other site
696281001495	phosphorylation site [posttranslational modification]
696281001496	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
696281001497	ATP binding site [chemical binding]; other site
696281001498	Mg2+ binding site [ion binding]; other site
696281001499	G-X-G motif; other site
696281001500	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
696281001501	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
696281001502	active site
696281001503	phosphorylation site [posttranslational modification]
696281001504	intermolecular recognition site; other site
696281001505	dimerization interface [polypeptide binding]; other site
696281001506	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
696281001507	DNA binding site [nucleotide binding]
696281001508	nascent polypeptide-associated complex protein; Reviewed; Region: nac; PRK06369
696281001509	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
696281001510	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
696281001511	putative active site [active]
696281001512	heme pocket [chemical binding]; other site
696281001513	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
696281001514	dimer interface [polypeptide binding]; other site
696281001515	phosphorylation site [posttranslational modification]
696281001516	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
696281001517	ATP binding site [chemical binding]; other site
696281001518	Mg2+ binding site [ion binding]; other site
696281001519	G-X-G motif; other site
696281001520	Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829
696281001521	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
696281001522	Walker A motif; other site
696281001523	ATP binding site [chemical binding]; other site
696281001524	Walker B motif; other site
696281001525	arginine finger; other site
696281001526	Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420
696281001527	L-cysteine desulfidase [Amino acid transport and metabolism]; Region: COG3681
696281001528	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
696281001529	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
696281001530	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
696281001531	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
696281001532	TM-ABC transporter signature motif; other site
696281001533	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
696281001534	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
696281001535	TM-ABC transporter signature motif; other site
696281001536	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
696281001537	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
696281001538	Walker A/P-loop; other site
696281001539	ATP binding site [chemical binding]; other site
696281001540	Q-loop/lid; other site
696281001541	ABC transporter signature motif; other site
696281001542	Walker B; other site
696281001543	D-loop; other site
696281001544	H-loop/switch region; other site
696281001545	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
696281001546	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
696281001547	Walker A/P-loop; other site
696281001548	ATP binding site [chemical binding]; other site
696281001549	Q-loop/lid; other site
696281001550	ABC transporter signature motif; other site
696281001551	Walker B; other site
696281001552	D-loop; other site
696281001553	H-loop/switch region; other site
696281001554	L-lactate permease [Energy production and conversion]; Region: LldP; COG1620
696281001555	L-lactate permease; Region: Lactate_perm; cl00701
696281001556	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
696281001557	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
696281001558	Predicted permeases [General function prediction only]; Region: RarD; COG2962
696281001559	EamA-like transporter family; Region: EamA; cl17759
696281001560	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
696281001561	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
696281001562	active site
696281001563	phosphorylation site [posttranslational modification]
696281001564	intermolecular recognition site; other site
696281001565	dimerization interface [polypeptide binding]; other site
696281001566	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
696281001567	DNA binding site [nucleotide binding]
696281001568	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
696281001569	dimerization interface [polypeptide binding]; other site
696281001570	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
696281001571	dimer interface [polypeptide binding]; other site
696281001572	phosphorylation site [posttranslational modification]
696281001573	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
696281001574	ATP binding site [chemical binding]; other site
696281001575	Mg2+ binding site [ion binding]; other site
696281001576	G-X-G motif; other site
696281001577	Polyferredoxin [Energy production and conversion]; Region: NapH; COG0348
696281001578	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
696281001579	dimerization interface [polypeptide binding]; other site
696281001580	putative DNA binding site [nucleotide binding]; other site
696281001581	putative Zn2+ binding site [ion binding]; other site
696281001582	ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591
696281001583	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
696281001584	FtsX-like permease family; Region: FtsX; pfam02687
696281001585	FtsX-like permease family; Region: FtsX; pfam02687
696281001586	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
696281001587	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
696281001588	Walker A/P-loop; other site
696281001589	ATP binding site [chemical binding]; other site
696281001590	Q-loop/lid; other site
696281001591	ABC transporter signature motif; other site
696281001592	Walker B; other site
696281001593	D-loop; other site
696281001594	H-loop/switch region; other site
696281001595	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
696281001596	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
696281001597	dimer interface [polypeptide binding]; other site
696281001598	phosphorylation site [posttranslational modification]
696281001599	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
696281001600	ATP binding site [chemical binding]; other site
696281001601	Mg2+ binding site [ion binding]; other site
696281001602	G-X-G motif; other site
696281001603	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
696281001604	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
696281001605	active site
696281001606	phosphorylation site [posttranslational modification]
696281001607	intermolecular recognition site; other site
696281001608	dimerization interface [polypeptide binding]; other site
696281001609	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
696281001610	DNA binding site [nucleotide binding]
696281001611	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
696281001612	MarR family; Region: MarR; pfam01047
696281001613	Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509
696281001614	hydroxyglutarate oxidase; Provisional; Region: PRK11728
696281001615	Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598
696281001616	Thermotoga maritima CorA-like family; Region: TmCorA-like; cd12822
696281001617	oligomer interface [polypeptide binding]; other site
696281001618	metal binding site [ion binding]; metal-binding site
696281001619	metal binding site [ion binding]; metal-binding site
696281001620	putative Cl binding site [ion binding]; other site
696281001621	aspartate ring; other site
696281001622	basic sphincter; other site
696281001623	hydrophobic gate; other site
696281001624	periplasmic entrance; other site
696281001625	glycyl-radical enzyme activating protein family; Region: PFLE_PFLC; TIGR02494
696281001626	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
696281001627	glycyl radical enzyme, PFL2/glycerol dehydratase family; Region: PFL2-3; TIGR01774
696281001628	Pyruvate formate lyase 2 and related enzymes; Region: PFL2_DhaB_BssA; cd01677
696281001629	dimer interface [polypeptide binding]; other site
696281001630	active site
696281001631	glycine loop; other site
696281001632	TfoX C-terminal domain; Region: TfoX_C; pfam04994
696281001633	Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230
696281001634	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
696281001635	S-adenosylmethionine binding site [chemical binding]; other site
696281001636	Sm and related proteins; Region: Sm_like; cl00259
696281001637	Sm1 motif; other site
696281001638	Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561
696281001639	Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257
696281001640	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064
696281001641	putative dimer interface [polypeptide binding]; other site
696281001642	[2Fe-2S] cluster binding site [ion binding]; other site
696281001643	Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980
696281001644	dimer interface [polypeptide binding]; other site
696281001645	[2Fe-2S] cluster binding site [ion binding]; other site
696281001646	NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894
696281001647	SLBB domain; Region: SLBB; pfam10531
696281001648	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928
696281001649	4Fe-4S binding domain; Region: Fer4; pfam00037
696281001650	4Fe-4S dicluster domain; Region: Fer4_10; pfam13237
696281001651	Ferredoxin [Energy production and conversion]; Region: NapF; COG1145
696281001652	4Fe-4S binding domain; Region: Fer4; pfam00037
696281001653	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
696281001654	catalytic loop [active]
696281001655	iron binding site [ion binding]; other site
696281001656	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588
696281001657	[FeFe] hydrogenase, group A; Region: FeFe_hydrog_A; TIGR02512
696281001658	Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906
696281001659	Iron hydrogenase small subunit; Region: Fe_hyd_SSU; pfam02256
696281001660	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
696281001661	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
696281001662	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
696281001663	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
696281001664	Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508
696281001665	PBP superfamily domain; Region: PBP_like_2; pfam12849
696281001666	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
696281001667	PBP superfamily domain; Region: PBP_like_2; pfam12849
696281001668	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
696281001669	MoeA_like. This domain is similar to a domain found in a variety of proteins involved in biosynthesis of molybdopterin cofactor, like MoaB, MogA, and MoeA. There this domain is presumed to bind molybdopterin. The exact function of this subgroup is...; Region: MoeA_like; cd03522
696281001670	putative MPT binding site; other site
696281001671	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
696281001672	selenium-dependent molybdenum hydroxylase 1; Region: Se_dep_Molyb_1; TIGR03311
696281001673	catalytic loop [active]
696281001674	iron binding site [ion binding]; other site
696281001675	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
696281001676	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
696281001677	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
696281001678	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
696281001679	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
696281001680	Cysteine-rich domain; Region: CCG; pfam02754
696281001681	Methyltransferase domain; Region: Methyltransf_31; pfam13847
696281001682	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
696281001683	S-adenosylmethionine binding site [chemical binding]; other site
696281001684	Putative redox-active protein (C_GCAxxG_C_C); Region: C_GCAxxG_C_C; pfam09719
696281001685	Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG1964
696281001686	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
696281001687	FeS/SAM binding site; other site
696281001688	Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541
696281001689	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
696281001690	acyl-activating enzyme (AAE) consensus motif; other site
696281001691	AMP binding site [chemical binding]; other site
696281001692	active site
696281001693	CoA binding site [chemical binding]; other site
696281001694	Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975
696281001695	XdhC and CoxI family; Region: XdhC_CoxI; pfam02625
696281001696	XdhC Rossmann domain; Region: XdhC_C; pfam13478
696281001697	GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182
696281001698	metal-binding site
696281001699	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
696281001700	Zn2+ binding site [ion binding]; other site
696281001701	Mg2+ binding site [ion binding]; other site
696281001702	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
696281001703	catalytic core [active]
696281001704	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
696281001705	catalytic core [active]
696281001706	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
696281001707	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
696281001708	molybdenum-pterin binding domain; Region: Mop; TIGR00638
696281001709	PBP superfamily domain; Region: PBP_like_2; cl17296
696281001710	ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725
696281001711	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
696281001712	membrane-bound complex binding site; other site
696281001713	hinge residues; other site
696281001714	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
696281001715	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
696281001716	dimer interface [polypeptide binding]; other site
696281001717	conserved gate region; other site
696281001718	putative PBP binding loops; other site
696281001719	ABC-ATPase subunit interface; other site
696281001720	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
696281001721	thiamine ABC transporter, ATP-binding protein; Region: thiQ; TIGR01277
696281001722	Walker A/P-loop; other site
696281001723	ATP binding site [chemical binding]; other site
696281001724	Q-loop/lid; other site
696281001725	ABC transporter signature motif; other site
696281001726	Walker B; other site
696281001727	D-loop; other site
696281001728	H-loop/switch region; other site
696281001729	1-pyrroline-5-carboxylate dehydrogenase; Provisional; Region: PRK03137
696281001730	Delta(1)-pyrroline-5-carboxylate dehydrogenase, RocA; Region: ALDH_PutA-P5CDH-RocA; cd07124
696281001731	Glutamate binding site [chemical binding]; other site
696281001732	homodimer interface [polypeptide binding]; other site
696281001733	NAD binding site [chemical binding]; other site
696281001734	catalytic residues [active]
696281001735	Uncharacterized conserved protein [Function unknown]; Region: COG1633
696281001736	Uncharacterized family of ferritin-like proteins found in archaea and bacteria; Region: Ferritin_like_AB; cd01045
696281001737	diiron binding motif [ion binding]; other site
696281001738	undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281
696281001739	Protein of unknown function (DUF1624); Region: DUF1624; pfam07786
696281001740	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
696281001741	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
696281001742	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
696281001743	active site
696281001744	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
696281001745	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: GT1_like_1; cd04950
696281001746	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
696281001747	putative homodimer interface [polypeptide binding]; other site
696281001748	Peptidase family M48; Region: Peptidase_M48; pfam01435
696281001749	Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436
696281001750	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
696281001751	pyridoxal 5'-phosphate binding site [chemical binding]; other site
696281001752	homodimer interface [polypeptide binding]; other site
696281001753	catalytic residue [active]
696281001754	DsrE/DsrF-like family; Region: DrsE; cl00672
696281001755	ferredoxin; Validated; Region: PRK07118
696281001756	Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785
696281001757	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; pfam02683
696281001758	Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334
696281001759	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
696281001760	NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076
696281001761	NAD(P) binding site [chemical binding]; other site
696281001762	Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels [Inorganic ion transport and metabolism]; Region: COG0490
696281001763	TrkA-C domain; Region: TrkA_C; pfam02080
696281001764	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
696281001765	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
696281001766	PAS domain; Region: PAS; smart00091
696281001767	PAS domain; Region: PAS_9; pfam13426
696281001768	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
696281001769	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
696281001770	ATP binding site [chemical binding]; other site
696281001771	Mg2+ binding site [ion binding]; other site
696281001772	G-X-G motif; other site
696281001773	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06710
696281001774	Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936
696281001775	acyl-activating enzyme (AAE) consensus motif; other site
696281001776	putative AMP binding site [chemical binding]; other site
696281001777	putative active site [active]
696281001778	putative CoA binding site [chemical binding]; other site
696281001779	Sporulation protein YtrH; Region: Spore_YtrH; pfam14034
696281001780	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
696281001781	NIPSNAP; Region: NIPSNAP; pfam07978
696281001782	Helix-turn-helix domain; Region: HTH_28; pfam13518
696281001783	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
696281001784	Helix-turn-helix domain; Region: HTH_28; pfam13518
696281001785	Beta propeller domain; Region: Beta_propel; pfam09826
696281001786	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
696281001787	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
696281001788	DNA-binding site [nucleotide binding]; DNA binding site
696281001789	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
696281001790	pyridoxal 5'-phosphate binding site [chemical binding]; other site
696281001791	homodimer interface [polypeptide binding]; other site
696281001792	catalytic residue [active]
696281001793	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
696281001794	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
696281001795	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
696281001796	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
696281001797	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
696281001798	Ankyrin repeats (many copies); Region: Ank_5; pfam13857
696281001799	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
696281001800	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
696281001801	Ankyrin repeats (many copies); Region: Ank_5; pfam13857
696281001802	Sodium Bile acid symporter family; Region: SBF; cl17470
696281001803	CHASE3 domain; Region: CHASE3; cl05000
696281001804	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
696281001805	dimerization interface [polypeptide binding]; other site
696281001806	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
696281001807	dimer interface [polypeptide binding]; other site
696281001808	Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015
696281001809	putative CheW interface [polypeptide binding]; other site
696281001810	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
696281001811	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
696281001812	Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929
696281001813	Uncharacterized protein conserved in bacteria (DUF2325); Region: DUF2325; pfam10087
696281001814	VanZ like family; Region: VanZ; cl01971
696281001815	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
696281001816	putative active site [active]
696281001817	Uncharacterized protein conserved in archaea (DUF2250); Region: DUF2250; pfam10007
696281001818	G:T/U mismatch specific DNA glcosylase (MUG); Region: UDG_F2_MUG; cd10028
696281001819	active site
696281001820	SUMO-1 interface [polypeptide binding]; other site
696281001821	Predicted transcriptional regulators [Transcription]; Region: COG1695
696281001822	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
696281001823	tungstate ABC transporter binding protein WtpA; Region: tungstate_WtpA; TIGR03730
696281001824	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
696281001825	Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872
696281001826	Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465
696281001827	active site
696281001828	NAD binding site [chemical binding]; other site
696281001829	metal binding site [ion binding]; metal-binding site
696281001830	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
696281001831	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
696281001832	DNA-binding site [nucleotide binding]; DNA binding site
696281001833	UTRA domain; Region: UTRA; pfam07702
696281001834	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
696281001835	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
696281001836	Walker A/P-loop; other site
696281001837	ATP binding site [chemical binding]; other site
696281001838	Q-loop/lid; other site
696281001839	ABC transporter signature motif; other site
696281001840	Walker B; other site
696281001841	D-loop; other site
696281001842	H-loop/switch region; other site
696281001843	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
696281001844	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432
696281001845	substrate binding pocket [chemical binding]; other site
696281001846	membrane-bound complex binding site; other site
696281001847	hinge residues; other site
696281001848	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
696281001849	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
696281001850	dimer interface [polypeptide binding]; other site
696281001851	conserved gate region; other site
696281001852	ABC-ATPase subunit interface; other site
696281001853	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
696281001854	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
696281001855	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
696281001856	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
696281001857	Walker A/P-loop; other site
696281001858	ATP binding site [chemical binding]; other site
696281001859	Q-loop/lid; other site
696281001860	ABC transporter signature motif; other site
696281001861	Walker B; other site
696281001862	D-loop; other site
696281001863	H-loop/switch region; other site
696281001864	Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686
696281001865	Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305
696281001866	hexamer interface [polypeptide binding]; other site
696281001867	ligand binding site [chemical binding]; other site
696281001868	putative active site [active]
696281001869	NAD(P) binding site [chemical binding]; other site
696281001870	aminotransferase; Validated; Region: PRK07678
696281001871	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
696281001872	inhibitor-cofactor binding pocket; inhibition site
696281001873	pyridoxal 5'-phosphate binding site [chemical binding]; other site
696281001874	catalytic residue [active]
696281001875	sulfoacetaldehyde acetyltransferase; Validated; Region: PRK07525
696281001876	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
696281001877	PYR/PP interface [polypeptide binding]; other site
696281001878	dimer interface [polypeptide binding]; other site
696281001879	TPP binding site [chemical binding]; other site
696281001880	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
696281001881	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629
696281001882	TPP-binding site [chemical binding]; other site
696281001883	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
696281001884	Major Facilitator Superfamily; Region: MFS_1; pfam07690
696281001885	putative substrate translocation pore; other site
696281001886	4Fe-4S dicluster domain; Region: Fer4_10; pfam13237
696281001887	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
696281001888	hybrid cluster protein; Provisional; Region: PRK05290
696281001889	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
696281001890	ACS interaction site; other site
696281001891	CODH interaction site; other site
696281001892	Hybrid cluster protein (HCP), formerly known as prismane, is thought to play a role in nitrogen metabolism but its specific function is unknown. HCP has three structural domains, an N-terminal alpha-helical domain, and two similar domains comprising a...; Region: HCP; cd01914
696281001893	hybrid metal cluster; other site
696281001894	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
696281001895	Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281
696281001896	Malic enzyme, N-terminal domain; Region: malic; pfam00390
696281001897	NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311
696281001898	putative NAD(P) binding site [chemical binding]; other site
696281001899	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
696281001900	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
696281001901	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
696281001902	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
696281001903	HlyD family secretion protein; Region: HlyD_3; pfam13437
696281001904	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
696281001905	C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663
696281001906	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
696281001907	D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295
696281001908	Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613
696281001909	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686
696281001910	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
696281001911	Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943
696281001912	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
696281001913	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
696281001914	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
696281001915	HlyD family secretion protein; Region: HlyD_3; pfam13437
696281001916	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
696281001917	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
696281001918	QacR-like protein, C-terminal region; Region: TetR_C_5; pfam08360
696281001919	Domain of unknown function (DUF4397); Region: DUF4397; pfam14344
696281001920	Domain of unknown function (DUF4397); Region: DUF4397; pfam14344
696281001921	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
696281001922	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
696281001923	nucleotide binding site [chemical binding]; other site
696281001924	Hexokinase; Region: Hexokinase_2; pfam03727
696281001925	HPP family; Region: HPP; pfam04982
696281001926	Rrf2 family protein; Region: rrf2_super; TIGR00738
696281001927	Transcriptional regulator; Region: Rrf2; pfam02082
696281001928	Uncharacterized family of ferritin-like proteins found in archaea and bacteria; Region: Ferritin_like_AB; cd01045
696281001929	diiron binding motif [ion binding]; other site
696281001930	Rubredoxin [Energy production and conversion]; Region: COG1773
696281001931	Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730
696281001932	iron binding site [ion binding]; other site
696281001933	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
696281001934	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
696281001935	catalytic site [active]
696281001936	Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116
696281001937	THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715
696281001938	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
696281001939	Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561
696281001940	bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805
696281001941	Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122
696281001942	putative catalytic cysteine [active]
696281001943	C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178
696281001944	putative active site [active]
696281001945	metal binding site [ion binding]; metal-binding site
696281001946	Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin; Region: ARM; cl02500
696281001947	protein binding surface [polypeptide binding]; other site
696281001948	HEAT-like repeat; Region: HEAT_EZ; pfam13513
696281001949	E-Z type HEAT repeats; Region: EZ_HEAT; smart00567
696281001950	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
696281001951	HlyD family secretion protein; Region: HlyD_3; pfam13437
696281001952	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
696281001953	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
696281001954	Walker A/P-loop; other site
696281001955	ATP binding site [chemical binding]; other site
696281001956	Q-loop/lid; other site
696281001957	ABC transporter signature motif; other site
696281001958	Walker B; other site
696281001959	D-loop; other site
696281001960	H-loop/switch region; other site
696281001961	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
696281001962	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
696281001963	FtsX-like permease family; Region: FtsX; pfam02687
696281001964	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
696281001965	EamA-like transporter family; Region: EamA; pfam00892
696281001966	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
696281001967	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
696281001968	DNA binding site [nucleotide binding]
696281001969	active site
696281001970	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
696281001971	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
696281001972	Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283
696281001973	Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
696281001974	Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
696281001975	PhoU domain; Region: PhoU; pfam01895
696281001976	Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230
696281001977	Methyltransferase domain; Region: Methyltransf_24; pfam13578
696281001978	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
696281001979	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
696281001980	active site
696281001981	peptide chain release factor 3; Provisional; Region: prfC; PRK00741
696281001982	Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169
696281001983	G1 box; other site
696281001984	putative GEF interaction site [polypeptide binding]; other site
696281001985	GTP/Mg2+ binding site [chemical binding]; other site
696281001986	Switch I region; other site
696281001987	G2 box; other site
696281001988	G3 box; other site
696281001989	Switch II region; other site
696281001990	G4 box; other site
696281001991	G5 box; other site
696281001992	RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689
696281001993	Uncharacterized conserved protein [Function unknown]; Region: COG5663
696281001994	haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702
696281001995	S-layer homology domain; Region: SLH; pfam00395
696281001996	S-layer homology domain; Region: SLH; pfam00395
696281001997	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
696281001998	non-specific DNA binding site [nucleotide binding]; other site
696281001999	salt bridge; other site
696281002000	sequence-specific DNA binding site [nucleotide binding]; other site
696281002001	Probable zinc-binding domain; Region: zf-trcl; pfam13451
696281002002	CxxC-x17-CxxC domain; Region: cxxc_cxxc_Mbark; TIGR04272
696281002003	Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070
696281002004	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
696281002005	FMN binding site [chemical binding]; other site
696281002006	substrate binding site [chemical binding]; other site
696281002007	putative catalytic residue [active]
696281002008	Mn-containing catalase [Inorganic ion transport and metabolism]; Region: COG3546
696281002009	dinuclear metal binding motif [ion binding]; other site
696281002010	Protein of unknown function (DUF2688); Region: DUF2688; pfam10892
696281002011	Conjugative transposon protein TcpC; Region: TpcC; pfam12642
696281002012	TcpE family; Region: TcpE; pfam12648
696281002013	AAA-like domain; Region: AAA_10; pfam12846
696281002014	RbsD / FucU transport protein family; Region: RbsD_FucU; cl00809
696281002015	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
696281002016	N-acetyl-D-glucosamine binding site [chemical binding]; other site
696281002017	catalytic residue [active]
696281002018	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
696281002019	Peptidase family M23; Region: Peptidase_M23; pfam01551
696281002020	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
696281002021	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
696281002022	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
696281002023	metal binding site [ion binding]; metal-binding site
696281002024	active site
696281002025	I-site; other site
696281002026	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
696281002027	AAA domain; Region: AAA_31; pfam13614
696281002028	Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455
696281002029	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
696281002030	Flp pilus assembly protein CpaB [Intracellular trafficking and secretion]; Region: CpaB; COG3745
696281002031	SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614
696281002032	Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455
696281002033	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
696281002034	Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962
696281002035	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
696281002036	Walker A motif; other site
696281002037	ATP binding site [chemical binding]; other site
696281002038	Walker B motif; other site
696281002039	Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965
696281002040	Flp pilus assembly protein TadC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: TadC; COG2064
696281002041	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
696281002042	Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989
696281002043	Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750
696281002044	Type IV leader peptidase family; Region: Peptidase_A24; pfam01478
696281002045	The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia.  This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775
696281002046	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604
696281002047	PIN domain of the Pyrobaculum aerophilum Pae0151 and Pae2754 proteins and homologs; Region: PIN_Pae0151; cd09873
696281002048	putative active site [active]
696281002049	homotetrameric interface [polypeptide binding]; other site
696281002050	metal binding site [ion binding]; metal-binding site
696281002051	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
696281002052	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
696281002053	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
696281002054	Uncharacterized conserved protein [Function unknown]; Region: COG5663
696281002055	Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227
696281002056	PRTRC system protein D; Region: PRTRC_D; TIGR03739
696281002057	Mg binding site [ion binding]; other site
696281002058	nucleotide binding site [chemical binding]; other site
696281002059	putative protofilament interface [polypeptide binding]; other site
696281002060	Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; cl00868
696281002061	AAA-like domain; Region: AAA_10; pfam12846
696281002062	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
696281002063	Walker A motif; other site
696281002064	ATP binding site [chemical binding]; other site
696281002065	Walker B motif; other site
696281002066	Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; cl00868
696281002067	30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676
696281002068	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
696281002069	Coenzyme A binding pocket [chemical binding]; other site
696281002070	Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cd00352
696281002071	active site
696281002072	Recombinase; Region: Recombinase; pfam07508
696281002073	tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224
696281002074	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
696281002075	active site
696281002076	Int/Topo IB signature motif; other site
696281002077	DNA binding site [nucleotide binding]
696281002078	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200
696281002079	DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674
696281002080	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
696281002081	Replication-relaxation; Region: Replic_Relax; pfam13814
696281002082	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
696281002083	non-specific DNA binding site [nucleotide binding]; other site
696281002084	salt bridge; other site
696281002085	sequence-specific DNA binding site [nucleotide binding]; other site
696281002086	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
696281002087	non-specific DNA binding site [nucleotide binding]; other site
696281002088	salt bridge; other site
696281002089	sequence-specific DNA binding site [nucleotide binding]; other site
696281002090	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
696281002091	non-specific DNA binding site [nucleotide binding]; other site
696281002092	salt bridge; other site
696281002093	sequence-specific DNA binding site [nucleotide binding]; other site
696281002094	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
696281002095	non-specific DNA binding site [nucleotide binding]; other site
696281002096	salt bridge; other site
696281002097	sequence-specific DNA binding site [nucleotide binding]; other site
696281002098	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
696281002099	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
696281002100	P-loop; other site
696281002101	Magnesium ion binding site [ion binding]; other site
696281002102	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
696281002103	Magnesium ion binding site [ion binding]; other site
696281002104	ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180
696281002105	ParB-like nuclease domain; Region: ParB; smart00470
696281002106	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
696281002107	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
696281002108	catalytic residues [active]
696281002109	catalytic nucleophile [active]
696281002110	Recombinase; Region: Recombinase; pfam07508
696281002111	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264
696281002112	CotJB protein; Region: CotJB; pfam12652
696281002113	Spore coat associated protein JA (CotJA); Region: CotJA; pfam11007
696281002114	glucose-6-phosphate isomerase; Provisional; Region: PRK00973
696281002115	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
696281002116	active site
696281002117	dimer interface [polypeptide binding]; other site
696281002118	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
696281002119	dimer interface [polypeptide binding]; other site
696281002120	active site
696281002121	Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705
696281002122	YmaF family; Region: YmaF; pfam12788
696281002123	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
696281002124	Coenzyme A binding pocket [chemical binding]; other site
696281002125	zinc-ribbon domain; Region: zf-ribbon_3; pfam13248
696281002126	acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895
696281002127	N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878
696281002128	putative valine binding site [chemical binding]; other site
696281002129	dimer interface [polypeptide binding]; other site
696281002130	Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369
696281002131	Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402
696281002132	PemK-like protein; Region: PemK; pfam02452
696281002133	Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071
696281002134	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745
696281002135	catalytic triad [active]
696281002136	Metallo-dependent hydrolases, subgroup C is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_C; cd01309
696281002137	Amidohydrolase; Region: Amidohydro_4; pfam13147
696281002138	active site
696281002139	Response regulator receiver domain; Region: Response_reg; pfam00072
696281002140	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
696281002141	active site
696281002142	phosphorylation site [posttranslational modification]
696281002143	intermolecular recognition site; other site
696281002144	dimerization interface [polypeptide binding]; other site
696281002145	Predicted ATPase or kinase [General function prediction only]; Region: COG0802
696281002146	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
696281002147	Glycoprotease family; Region: Peptidase_M22; pfam00814
696281002148	ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575
696281002149	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
696281002150	Coenzyme A binding pocket [chemical binding]; other site
696281002151	UGMP family protein; Validated; Region: PRK09604
696281002152	Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884
696281002153	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
696281002154	phenylacetate-CoA ligase; Region: PA_CoA_ligase; TIGR02155
696281002155	acyl-activating enzyme (AAE) consensus motif; other site
696281002156	AMP binding site [chemical binding]; other site
696281002157	active site
696281002158	CoA binding site [chemical binding]; other site
696281002159	ACT domain-containing protein [General function prediction only]; Region: COG4747
696281002160	N-terminal ACT domain of a novel protein composed almost entirely of two tandem ACT domains; Region: ACT_Bt0572_1; cd04908
696281002161	C-terminal ACT domain of a novel protein composed of just two ACT domains; Region: ACT_Bt0572_2; cd04882
696281002162	5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812
696281002163	5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727
696281002164	Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519
696281002165	Putative zinc-finger; Region: zf-HC2; pfam13490
696281002166	RNA polymerase sigma factor SigW; Provisional; Region: PRK09641
696281002167	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
696281002168	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
696281002169	DNA binding residues [nucleotide binding]
696281002170	coproporphyrinogen III oxidase; Provisional; Region: PRK08207
696281002171	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
696281002172	FeS/SAM binding site; other site
696281002173	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
696281002174	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
696281002175	dimer interface [polypeptide binding]; other site
696281002176	putative functional site; other site
696281002177	putative MPT binding site; other site
696281002178	putative molybdopterin biosynthesis protein MoeA/LysR substrate binding-domain-containing protein; Provisional; Region: PRK14498
696281002179	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
696281002180	dimer interface [polypeptide binding]; other site
696281002181	putative functional site; other site
696281002182	putative MPT binding site; other site
696281002183	PBP superfamily domain; Region: PBP_like; pfam12727
696281002184	N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; COG2005
696281002185	FdhD/NarQ family; Region: FdhD-NarQ; pfam02634
696281002186	MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886
696281002187	MPT binding site; other site
696281002188	trimer interface [polypeptide binding]; other site
696281002189	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
696281002190	oligomerisation interface [polypeptide binding]; other site
696281002191	mobile loop; other site
696281002192	roof hairpin; other site
696281002193	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
696281002194	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
696281002195	ring oligomerisation interface [polypeptide binding]; other site
696281002196	ATP/Mg binding site [chemical binding]; other site
696281002197	stacking interactions; other site
696281002198	hinge regions; other site
696281002199	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
696281002200	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
696281002201	dimer interface [polypeptide binding]; other site
696281002202	pyridoxal 5'-phosphate binding site [chemical binding]; other site
696281002203	catalytic residue [active]
696281002204	Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967
696281002205	nucleotidyl binding site; other site
696281002206	metal binding site [ion binding]; metal-binding site
696281002207	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
696281002208	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the GGDEF (DiGuanylate-Cyclase (DGC)) domain. The GGDEF domain has been suggested to be homologous to the adenylyl cyclase catalytic domain and...; Region: CBS_pair_GGDEF_assoc; cd04598
696281002209	FOG: CBS domain [General function prediction only]; Region: COG0517
696281002210	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
696281002211	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
696281002212	metal binding site [ion binding]; metal-binding site
696281002213	active site
696281002214	I-site; other site
696281002215	acetyl-CoA synthetase; Provisional; Region: PRK00174
696281002216	Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966
696281002217	active site
696281002218	CoA binding site [chemical binding]; other site
696281002219	acyl-activating enzyme (AAE) consensus motif; other site
696281002220	AMP binding site [chemical binding]; other site
696281002221	acetate binding site [chemical binding]; other site
696281002222	GAF domain; Region: GAF; pfam01590
696281002223	Histidine kinase; Region: His_kinase; pfam06580
696281002224	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
696281002225	ATP binding site [chemical binding]; other site
696281002226	Mg2+ binding site [ion binding]; other site
696281002227	G-X-G motif; other site
696281002228	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
696281002229	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
696281002230	active site
696281002231	phosphorylation site [posttranslational modification]
696281002232	intermolecular recognition site; other site
696281002233	dimerization interface [polypeptide binding]; other site
696281002234	LytTr DNA-binding domain; Region: LytTR; smart00850
696281002235	4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070
696281002236	Uncharacterized conserved protein [Function unknown]; Region: COG0062
696281002237	putative carbohydrate kinase; Provisional; Region: PRK10565
696281002238	B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171
696281002239	putative substrate binding site [chemical binding]; other site
696281002240	putative ATP binding site [chemical binding]; other site
696281002241	TIR domain; Region: TIR_2; pfam13676
696281002242	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
696281002243	homotrimer interaction site [polypeptide binding]; other site
696281002244	putative active site [active]
696281002245	Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422
696281002246	active site
696281002247	dimer interfaces [polypeptide binding]; other site
696281002248	catalytic residues [active]
696281002249	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
696281002250	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
696281002251	active site
696281002252	phosphorylation site [posttranslational modification]
696281002253	intermolecular recognition site; other site
696281002254	dimerization interface [polypeptide binding]; other site
696281002255	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
696281002256	DNA binding site [nucleotide binding]
696281002257	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
696281002258	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
696281002259	dimerization interface [polypeptide binding]; other site
696281002260	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
696281002261	dimer interface [polypeptide binding]; other site
696281002262	phosphorylation site [posttranslational modification]
696281002263	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
696281002264	ATP binding site [chemical binding]; other site
696281002265	Mg2+ binding site [ion binding]; other site
696281002266	G-X-G motif; other site
696281002267	outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302
696281002268	translocation protein TolB; Provisional; Region: tolB; PRK04922
696281002269	tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800
696281002270	Domain of unknown function (DUF4309); Region: DUF4309; pfam14172
696281002271	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
696281002272	MarR family; Region: MarR; pfam01047
696281002273	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
696281002274	active site
696281002275	catalytic residues [active]
696281002276	metal binding site [ion binding]; metal-binding site
696281002277	ATP-binding cassette domain of MutS-like homolog; Region: ABC_MutS-like; cd03283
696281002278	Walker A/P-loop; other site
696281002279	ATP binding site [chemical binding]; other site
696281002280	Q-loop/lid; other site
696281002281	ABC transporter signature motif; other site
696281002282	Walker B; other site
696281002283	D-loop; other site
696281002284	H-loop/switch region; other site
696281002285	Transposase domain (DUF772); Region: DUF772; pfam05598
696281002286	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
696281002287	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
696281002288	Protein of unknown function (DUF3189); Region: DUF3189; pfam11385
696281002289	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430
696281002290	alanine racemase; Reviewed; Region: alr; PRK00053
696281002291	active site
696281002292	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
696281002293	dimer interface [polypeptide binding]; other site
696281002294	substrate binding site [chemical binding]; other site
696281002295	catalytic residues [active]
696281002296	Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707
696281002297	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736
696281002298	active site
696281002299	phosphorylation site [posttranslational modification]
696281002300	intermolecular recognition site; other site
696281002301	dimerization interface [polypeptide binding]; other site
696281002302	ANTAR domain; Region: ANTAR; pfam03861
696281002303	Nitrogen regulatory protein P-II; Region: P-II; pfam00543
696281002304	Nitrogen regulatory protein P-II; Region: P-II; smart00938
696281002305	Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004
696281002306	Nitrogen regulatory protein P-II; Region: P-II; pfam00543
696281002307	Nitrogen regulatory protein P-II; Region: P-II; smart00938
696281002308	S-layer homology domain; Region: SLH; pfam00395
696281002309	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
696281002310	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
696281002311	active site
696281002312	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
696281002313	active site
696281002314	metal binding site [ion binding]; metal-binding site
696281002315	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
696281002316	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
696281002317	CHASE3 domain; Region: CHASE3; cl05000
696281002318	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
696281002319	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
696281002320	dimerization interface [polypeptide binding]; other site
696281002321	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
696281002322	dimer interface [polypeptide binding]; other site
696281002323	putative CheW interface [polypeptide binding]; other site
696281002324	PAS domain; Region: PAS; smart00091
696281002325	PAS domain; Region: PAS_9; pfam13426
696281002326	putative active site [active]
696281002327	heme pocket [chemical binding]; other site
696281002328	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
696281002329	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
696281002330	Zn2+ binding site [ion binding]; other site
696281002331	Mg2+ binding site [ion binding]; other site
696281002332	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
696281002333	Putative catalytic NodB homology domain of uncharacterized BH1302 protein from Bacillus halodurans and its bacterial homologs; Region: CE4_BH1302_like; cd10956
696281002334	NodB motif; other site
696281002335	putative active site [active]
696281002336	putative catalytic site [active]
696281002337	putative Zn binding site [ion binding]; other site
696281002338	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG2607
696281002339	Protein of unknown function (DUF815); Region: DUF815; pfam05673
696281002340	Walker A motif; other site
696281002341	ATP binding site [chemical binding]; other site
696281002342	Walker B motif; other site
696281002343	FMN-binding domain; Region: FMN_bind; cl01081
696281002344	RNA replicase, beta subunit; Region: rep; PHA00028
696281002345	S-layer homology domain; Region: SLH; pfam00395
696281002346	S-layer homology domain; Region: SLH; pfam00395
696281002347	S-layer homology domain; Region: SLH; pfam00395
696281002348	Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477
696281002349	ApbE family; Region: ApbE; pfam02424
696281002350	Listerrria innocua Lin0431  is similar to the N-Utilization Substance G (NusG) N terminal (NGN) insert (DII); Region: Lin0431_like; cd09911
696281002351	trimer interface [polypeptide binding]; other site
696281002352	Heptaprenyl diphosphate synthase component I; Region: Hpre_diP_synt_I; pfam07456
696281002353	putative transposase OrfB; Reviewed; Region: PHA02517
696281002354	HTH-like domain; Region: HTH_21; pfam13276
696281002355	Integrase core domain; Region: rve; pfam00665
696281002356	Integrase core domain; Region: rve_2; pfam13333
696281002357	Helix-turn-helix domain; Region: HTH_28; pfam13518
696281002358	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
696281002359	Helix-turn-helix domain; Region: HTH_28; pfam13518
696281002360	Predicted transcriptional regulators [Transcription]; Region: COG1733
696281002361	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
696281002362	Tellurite-resistance/Dicarboxylate Transporter (TDT) family includes SLAC1 (Slow Anion Channel-Associated 1); Region: TDT_SLAC1_like; cd09323
696281002363	gating phenylalanine in ion channel; other site
696281002364	Predicted transcriptional regulators [Transcription]; Region: COG1695
696281002365	Transcriptional regulator PadR-like family; Region: PadR; cl17335
696281002366	Predicted transcriptional regulators [Transcription]; Region: COG1733
696281002367	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
696281002368	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
696281002369	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
696281002370	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
696281002371	PAS fold; Region: PAS_4; pfam08448
696281002372	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
696281002373	putative active site [active]
696281002374	heme pocket [chemical binding]; other site
696281002375	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
696281002376	PAS domain; Region: PAS_9; pfam13426
696281002377	putative active site [active]
696281002378	heme pocket [chemical binding]; other site
696281002379	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
696281002380	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
696281002381	putative active site [active]
696281002382	heme pocket [chemical binding]; other site
696281002383	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
696281002384	dimer interface [polypeptide binding]; other site
696281002385	phosphorylation site [posttranslational modification]
696281002386	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
696281002387	ATP binding site [chemical binding]; other site
696281002388	Mg2+ binding site [ion binding]; other site
696281002389	G-X-G motif; other site
696281002390	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
696281002391	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
696281002392	active site
696281002393	phosphorylation site [posttranslational modification]
696281002394	intermolecular recognition site; other site
696281002395	dimerization interface [polypeptide binding]; other site
696281002396	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
696281002397	Walker A motif; other site
696281002398	ATP binding site [chemical binding]; other site
696281002399	Walker B motif; other site
696281002400	arginine finger; other site
696281002401	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
696281002402	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
696281002403	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
696281002404	ligand binding site [chemical binding]; other site
696281002405	flexible hinge region; other site
696281002406	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
696281002407	putative switch regulator; other site
696281002408	non-specific DNA interactions [nucleotide binding]; other site
696281002409	DNA binding site [nucleotide binding]
696281002410	sequence specific DNA binding site [nucleotide binding]; other site
696281002411	putative cAMP binding site [chemical binding]; other site
696281002412	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
696281002413	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
696281002414	transmembrane helices; other site
696281002415	adenylylsulfate reductase subunit alpha; Validated; Region: PRK06854
696281002416	L-aspartate oxidase; Provisional; Region: PRK06175
696281002417	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
696281002418	adenosine phosphosulphate reductase, beta subunit; Region: aprB; TIGR02060
696281002419	S-layer homology domain; Region: SLH; pfam00395
696281002420	S-layer homology domain; Region: SLH; pfam00395
696281002421	hypothetical protein; Provisional; Region: PRK06851
696281002422	hypothetical protein; Provisional; Region: PRK06761
696281002423	Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835
696281002424	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
696281002425	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
696281002426	dimerization interface [polypeptide binding]; other site
696281002427	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
696281002428	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
696281002429	dimer interface [polypeptide binding]; other site
696281002430	putative CheW interface [polypeptide binding]; other site
696281002431	PAS domain S-box; Region: sensory_box; TIGR00229
696281002432	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
696281002433	putative active site [active]
696281002434	heme pocket [chemical binding]; other site
696281002435	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
696281002436	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
696281002437	putative active site [active]
696281002438	heme pocket [chemical binding]; other site
696281002439	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
696281002440	putative active site [active]
696281002441	heme pocket [chemical binding]; other site
696281002442	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
696281002443	PAS domain; Region: PAS_9; pfam13426
696281002444	putative active site [active]
696281002445	heme pocket [chemical binding]; other site
696281002446	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
696281002447	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
696281002448	metal binding site [ion binding]; metal-binding site
696281002449	active site
696281002450	I-site; other site
696281002451	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
696281002452	Glutamine amidotransferases class-II (GATase) asparagine synthase_B type.  Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a  glutaminase domain and a...; Region: AsnB; cd00712
696281002453	active site
696281002454	asparagine synthase (glutamine-hydrolyzing); Region: asn_synth_AEB; TIGR01536
696281002455	dimer interface [polypeptide binding]; other site
696281002456	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
696281002457	Ligand Binding Site [chemical binding]; other site
696281002458	Molecular Tunnel; other site
696281002459	Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707
696281002460	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
696281002461	active site
696281002462	phosphorylation site [posttranslational modification]
696281002463	intermolecular recognition site; other site
696281002464	dimerization interface [polypeptide binding]; other site
696281002465	ANTAR domain; Region: ANTAR; pfam03861
696281002466	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
696281002467	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
696281002468	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
696281002469	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
696281002470	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
696281002471	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
696281002472	glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750
696281002473	Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713
696281002474	active site
696281002475	dimer interface [polypeptide binding]; other site
696281002476	Glutamate synthase central domain; Region: Glu_syn_central; pfam04898
696281002477	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
696281002478	active site
696281002479	FMN binding site [chemical binding]; other site
696281002480	substrate binding site [chemical binding]; other site
696281002481	3Fe-4S cluster binding site [ion binding]; other site
696281002482	gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982
696281002483	domain interface; other site
696281002484	glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810
696281002485	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
696281002486	putative transposase OrfB; Reviewed; Region: PHA02517
696281002487	HTH-like domain; Region: HTH_21; pfam13276
696281002488	Integrase core domain; Region: rve; pfam00665
696281002489	Integrase core domain; Region: rve_2; pfam13333
696281002490	Helix-turn-helix domain; Region: HTH_28; pfam13518
696281002491	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
696281002492	Helix-turn-helix domain; Region: HTH_28; pfam13518
696281002493	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
696281002494	putative catalytic site [active]
696281002495	putative metal binding site [ion binding]; other site
696281002496	putative phosphate binding site [ion binding]; other site
696281002497	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
696281002498	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
696281002499	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
696281002500	Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486
696281002501	NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl17195
696281002502	LDH/MDH dimer interface [polypeptide binding]; other site
696281002503	NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl17195
696281002504	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
696281002505	Mechanosensitive ion channel; Region: MS_channel; pfam00924
696281002506	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4200
696281002507	ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730
696281002508	ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730
696281002509	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
696281002510	ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268
696281002511	Walker A/P-loop; other site
696281002512	ATP binding site [chemical binding]; other site
696281002513	Q-loop/lid; other site
696281002514	ABC transporter signature motif; other site
696281002515	Walker B; other site
696281002516	D-loop; other site
696281002517	H-loop/switch region; other site
696281002518	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
696281002519	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
696281002520	active site
696281002521	phosphorylation site [posttranslational modification]
696281002522	intermolecular recognition site; other site
696281002523	dimerization interface [polypeptide binding]; other site
696281002524	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
696281002525	DNA binding site [nucleotide binding]
696281002526	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
696281002527	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
696281002528	dimer interface [polypeptide binding]; other site
696281002529	phosphorylation site [posttranslational modification]
696281002530	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
696281002531	ATP binding site [chemical binding]; other site
696281002532	Mg2+ binding site [ion binding]; other site
696281002533	G-X-G motif; other site
696281002534	Protein of unknown function (DUF1113); Region: DUF1113; pfam06541
696281002535	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
696281002536	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
696281002537	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
696281002538	Group of bacterial proteins containing an alpha crystallin domain (ACD) similar to Lactobacillus plantarum (Lp) small heat shock proteins (sHsp) HSP 18.5, HSP 18.55 and HSP 19.3. sHsps are molecular chaperones that suppress protein aggregation and...; Region: ACD_LpsHSP_like; cd06471
696281002539	putative dimer interface [polypeptide binding]; other site
696281002540	Putative redox-active protein (C_GCAxxG_C_C); Region: C_GCAxxG_C_C; pfam09719
696281002541	Protein of unknown function (DUF3189); Region: DUF3189; pfam11385
696281002542	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
696281002543	putative CheW interface [polypeptide binding]; other site
696281002544	Uncharacterized conserved protein (DUF2164); Region: DUF2164; pfam09932
696281002545	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
696281002546	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
696281002547	Walker A/P-loop; other site
696281002548	ATP binding site [chemical binding]; other site
696281002549	Q-loop/lid; other site
696281002550	ABC transporter signature motif; other site
696281002551	Walker B; other site
696281002552	D-loop; other site
696281002553	H-loop/switch region; other site
696281002554	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
696281002555	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
696281002556	dimer interface [polypeptide binding]; other site
696281002557	conserved gate region; other site
696281002558	putative PBP binding loops; other site
696281002559	ABC-ATPase subunit interface; other site
696281002560	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
696281002561	ABC transporter periplasmic binding protein, urea carboxylase region; Region: ABC_peri_uca; TIGR03427
696281002562	Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283
696281002563	Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
696281002564	Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
696281002565	PhoU domain; Region: PhoU; pfam01895
696281002566	PhoU domain; Region: PhoU; pfam01895
696281002567	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
696281002568	global nitrogen regulator NtcA, cyanobacterial; Region: NtcA_cyano; TIGR03697
696281002569	ligand binding site [chemical binding]; other site
696281002570	flexible hinge region; other site
696281002571	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
696281002572	putative switch regulator; other site
696281002573	non-specific DNA interactions [nucleotide binding]; other site
696281002574	DNA binding site [nucleotide binding]
696281002575	sequence specific DNA binding site [nucleotide binding]; other site
696281002576	putative cAMP binding site [chemical binding]; other site
696281002577	carbon-monoxide dehydrogenase, catalytic subunit; Region: CO_DH_cata; TIGR01702
696281002578	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
696281002579	ACS interaction site; other site
696281002580	CODH interaction site; other site
696281002581	metal cluster binding site [ion binding]; other site
696281002582	CO dehydrogenase maturation factor [Cell division and chromosome partitioning]; Region: CooC; COG3640
696281002583	The accessory protein CooC, which contains a nucleotide-binding domain (P-loop) near the N-terminus, participates in the maturation of the nickel center of carbon monoxide dehydrogenase (CODH). CODH from Rhodospirillum rubrum catalyzes the reversible...; Region: CooC; cd02034
696281002584	P-loop; other site
696281002585	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
696281002586	Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer,  utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514
696281002587	FMN binding site [chemical binding]; other site
696281002588	dimer interface [polypeptide binding]; other site
696281002589	Protein of unknown function DUF45; Region: DUF45; pfam01863
696281002590	Transposase; Region: DEDD_Tnp_IS110; pfam01548
696281002591	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
696281002592	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
696281002593	solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336
696281002594	Na2 binding site [ion binding]; other site
696281002595	putative substrate binding site 1 [chemical binding]; other site
696281002596	Na binding site 1 [ion binding]; other site
696281002597	putative substrate binding site 2 [chemical binding]; other site
696281002598	Zinc dependent phospholipase C (alpha toxin); Region: Zn_dep_PLPC; cd11009
696281002599	Zn binding site [ion binding]; other site
696281002600	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
696281002601	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
696281002602	NlpC/P60 family; Region: NLPC_P60; pfam00877
696281002603	S-layer homology domain; Region: SLH; pfam00395
696281002604	S-layer homology domain; Region: SLH; pfam00395
696281002605	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
696281002606	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
696281002607	dimerization interface [polypeptide binding]; other site
696281002608	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
696281002609	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
696281002610	dimer interface [polypeptide binding]; other site
696281002611	putative CheW interface [polypeptide binding]; other site
696281002612	Sporulation and spore germination; Region: Germane; pfam10646
696281002613	GAF domain; Region: GAF_2; pfam13185
696281002614	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
696281002615	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
696281002616	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
696281002617	Zn2+ binding site [ion binding]; other site
696281002618	Mg2+ binding site [ion binding]; other site
696281002619	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
696281002620	dimer interface [polypeptide binding]; other site
696281002621	putative CheW interface [polypeptide binding]; other site
696281002622	This entry represents the core domain of the ferrous iron (Fe2+) transport protein FeoA found in bacteria; Region: FeoA; smart00899
696281002623	Fe2+ transport system protein A [Inorganic ion transport and metabolism]; Region: FeoA; COG1918
696281002624	Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370
696281002625	Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879
696281002626	G1 box; other site
696281002627	GTP/Mg2+ binding site [chemical binding]; other site
696281002628	Switch I region; other site
696281002629	G2 box; other site
696281002630	G3 box; other site
696281002631	Switch II region; other site
696281002632	G4 box; other site
696281002633	G5 box; other site
696281002634	Nucleoside recognition; Region: Gate; pfam07670
696281002635	Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664
696281002636	Nucleoside recognition; Region: Gate; pfam07670
696281002637	heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525
696281002638	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
696281002639	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
696281002640	motif I; other site
696281002641	motif II; other site
696281002642	5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222
696281002643	CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312
696281002644	THF binding site; other site
696281002645	CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311
696281002646	substrate binding site [chemical binding]; other site
696281002647	THF binding site; other site
696281002648	zinc-binding site [ion binding]; other site
696281002649	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565
696281002650	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
696281002651	NAD(P) binding site [chemical binding]; other site
696281002652	active site
696281002653	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4564
696281002654	Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049
696281002655	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
696281002656	dimerization interface [polypeptide binding]; other site
696281002657	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
696281002658	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
696281002659	dimer interface [polypeptide binding]; other site
696281002660	putative CheW interface [polypeptide binding]; other site
696281002661	Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645
696281002662	active site
696281002663	SAM binding site [chemical binding]; other site
696281002664	homodimer interface [polypeptide binding]; other site
696281002665	Cobalt chelatase (CbiK); Region: CbiK; pfam06180
696281002666	Anaerobic cobalamin biosynthetic cobalt chelatase (CbiK), N-terminal domain. CbiK is part of the cobalt-early path for cobalamin biosynthesis. It catalyzes the insertion of cobalt into the oxidized form of precorrin-2, factor II (sirohydrochlorin), the...; Region: CbiK_N; cd03412
696281002667	active site
696281002668	C-terminal domain interface [polypeptide binding]; other site
696281002669	Anaerobic cobalamin biosynthetic cobalt chelatase (CbiK), C-terminal domain. CbiK is part of the cobalt-early path for cobalamin biosynthesis. It catalyzes the insertion of cobalt into the oxidized form of precorrin-2, factor II (sirohydrochlorin), the...; Region: CbiK_C; cd03413
696281002670	active site
696281002671	N-terminal domain interface [polypeptide binding]; other site
696281002672	Phosphoribosyltransferase; Region: DBI_PRT; pfam02277
696281002673	Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439
696281002674	putative dimer interface [polypeptide binding]; other site
696281002675	active site pocket [active]
696281002676	putative cataytic base [active]
696281002677	manganese transport transcriptional regulator; Provisional; Region: PRK03902
696281002678	Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325
696281002679	Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742
696281002680	Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370
696281002681	Nucleoside recognition; Region: Gate; pfam07670
696281002682	Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664
696281002683	Nucleoside recognition; Region: Gate; pfam07670
696281002684	Ferrous iron transport protein B; Region: FeoB_N; pfam02421
696281002685	Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879
696281002686	G1 box; other site
696281002687	GTP/Mg2+ binding site [chemical binding]; other site
696281002688	Switch I region; other site
696281002689	G2 box; other site
696281002690	G3 box; other site
696281002691	Switch II region; other site
696281002692	G4 box; other site
696281002693	G5 box; other site
696281002694	FeoA domain; Region: FeoA; pfam04023
696281002695	YibE/F-like protein; Region: YibE_F; pfam07907
696281002696	Uncharacterized protein conserved in bacteria (DUF2325); Region: DUF2325; pfam10087
696281002697	prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK12437
696281002698	cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077
696281002699	dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090
696281002700	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130
696281002701	catalytic triad [active]
696281002702	cobalt-precorrin-6A synthase; Reviewed; Region: cbiD; PRK00075
696281002703	Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644
696281002704	active site
696281002705	putative homodimer interface [polypeptide binding]; other site
696281002706	SAM binding site [chemical binding]; other site
696281002707	Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242
696281002708	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
696281002709	S-adenosylmethionine binding site [chemical binding]; other site
696281002710	Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641
696281002711	active site
696281002712	SAM binding site [chemical binding]; other site
696281002713	homodimer interface [polypeptide binding]; other site
696281002714	cobalamin biosynthesis protein CbiG; Validated; Region: PRK05788
696281002715	Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760
696281002716	Cobalamin biosynthesis central region; Region: CbiG_mid; pfam11761
696281002717	Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890
696281002718	Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646
696281002719	active site
696281002720	SAM binding site [chemical binding]; other site
696281002721	homodimer interface [polypeptide binding]; other site
696281002722	Precorrin-6x reductase CbiJ/CobK; Region: CbiJ; cl00922
696281002723	Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138
696281002724	Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416
696281002725	putative active site [active]
696281002726	cobalt-precorrin-8X methylmutase; Validated; Region: cbiC; cl00913
696281002727	Precorrin-8X methylmutase; Region: CbiC; pfam02570
696281002728	cobyric acid synthase; Provisional; Region: PRK00784
696281002729	Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132
696281002730	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750
696281002731	catalytic triad [active]
696281002732	CobD/Cbib protein; Region: CobD_Cbib; pfam03186
696281002733	cobalamin synthase; Reviewed; Region: cobS; PRK00235
696281002734	Protein involved in propanediol utilization, and related proteins (includes coumermycin biosynthetic protein), possible kinase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduX; COG4542
696281002735	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
696281002736	L-threonine-O-3-phosphate decarboxylase; Region: L_thr_O3P_dcar; TIGR01140
696281002737	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
696281002738	pyridoxal 5'-phosphate binding site [chemical binding]; other site
696281002739	homodimer interface [polypeptide binding]; other site
696281002740	catalytic residue [active]
696281002741	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
696281002742	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
696281002743	metal binding site [ion binding]; metal-binding site
696281002744	active site
696281002745	I-site; other site
696281002746	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
696281002747	ATP binding site [chemical binding]; other site
696281002748	putative Mg++ binding site [ion binding]; other site
696281002749	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
696281002750	nucleotide binding region [chemical binding]; other site
696281002751	ATP-binding site [chemical binding]; other site
696281002752	DSHCT (NUC185) domain; Region: DSHCT; pfam08148
696281002753	Protein of unknown function (DUF541); Region: SIMPL; pfam04402
696281002754	Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340
696281002755	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
696281002756	S-layer homology domain; Region: SLH; pfam00395
696281002757	ascorbic acid mannose pathway regulator 1; Provisional; Region: PLN03215
696281002758	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
696281002759	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
696281002760	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
696281002761	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
696281002762	Bacterial SH3 domain; Region: SH3_3; pfam08239
696281002763	Bacterial SH3 domain; Region: SH3_3; pfam08239
696281002764	Bacterial SH3 domain; Region: SH3_3; pfam08239
696281002765	AMIN domain; Region: AMIN; pfam11741
696281002766	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
696281002767	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
696281002768	active site
696281002769	metal binding site [ion binding]; metal-binding site
696281002770	B12 binding domain of glutamate mutase (Glm). Glutamate mutase catalysis the conversion of (S)-glutamate with (2S,3S)-3-methylaspartate. The rearrangement reaction is initiated by the extraction of a hydrogen from the protein-bound substrate by a 5'...; Region: Glm_B12_BD; cd02072
696281002771	B12 binding site [chemical binding]; other site
696281002772	heterodimer interface [polypeptide binding]; other site
696281002773	cobalt ligand [ion binding]; other site
696281002774	MutL protein; Region: MutL; pfam13941
696281002775	Coenzyme B12-dependent glutamate mutase epsilon subunit-like family; contains proteins similar to Clostridium cochlearium glutamate mutase (Glm) and Streptomyces tendae Tu901 NikV. Glm catalyzes a carbon-skeleton rearrangement of L-glutamate to...; Region: Glm_e; cd00245
696281002776	substrate binding site [chemical binding]; other site
696281002777	B12 cofactor binding site [chemical binding]; other site
696281002778	heterodimer (sigma-epsilon) interface [polypeptide binding]; other site
696281002779	homodimer (epsilon-epsilon) interface [polypeptide binding]; other site
696281002780	methylaspartate ammonia-lyase; Region: B_methylAsp_ase; TIGR01502
696281002781	Methylaspartate ammonia lyase (3-methylaspartase, MAL) is a homodimeric enzyme, catalyzing the magnesium-dependent reversible alpha,beta-elimination of ammonia from L-threo-(2S,3S)-3-methylaspartic acid to mesaconic acid. This reaction is part of the...; Region: MAL; cd03314
696281002782	dimer interface [polypeptide binding]; other site
696281002783	active site
696281002784	2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050
696281002785	BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271
696281002786	Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234
696281002787	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469
696281002788	ribonuclease PH; Reviewed; Region: rph; PRK00173
696281002789	Ribonuclease PH; Region: RNase_PH_bact; cd11362
696281002790	hexamer interface [polypeptide binding]; other site
696281002791	active site
696281002792	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
696281002793	active site
696281002794	dimerization interface [polypeptide binding]; other site
696281002795	Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841
696281002796	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
696281002797	active site
696281002798	metal binding site [ion binding]; metal-binding site
696281002799	homotetramer interface [polypeptide binding]; other site
696281002800	Protein of unknown function (DUF3788); Region: DUF3788; pfam12663
696281002801	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
696281002802	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
696281002803	Walker A/P-loop; other site
696281002804	ATP binding site [chemical binding]; other site
696281002805	Q-loop/lid; other site
696281002806	ABC transporter signature motif; other site
696281002807	Walker B; other site
696281002808	D-loop; other site
696281002809	H-loop/switch region; other site
696281002810	HlyD family secretion protein; Region: HlyD_2; pfam12700
696281002811	HlyD family secretion protein; Region: HlyD_3; pfam13437
696281002812	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
696281002813	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
696281002814	FtsX-like permease family; Region: FtsX; pfam02687
696281002815	Outer membrane efflux protein; Region: OEP; pfam02321
696281002816	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
696281002817	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
696281002818	dimerization interface [polypeptide binding]; other site
696281002819	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
696281002820	dimer interface [polypeptide binding]; other site
696281002821	phosphorylation site [posttranslational modification]
696281002822	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
696281002823	ATP binding site [chemical binding]; other site
696281002824	Mg2+ binding site [ion binding]; other site
696281002825	G-X-G motif; other site
696281002826	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
696281002827	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
696281002828	active site
696281002829	phosphorylation site [posttranslational modification]
696281002830	intermolecular recognition site; other site
696281002831	dimerization interface [polypeptide binding]; other site
696281002832	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
696281002833	DNA binding site [nucleotide binding]
696281002834	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
696281002835	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
696281002836	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
696281002837	dimer interface [polypeptide binding]; other site
696281002838	putative CheW interface [polypeptide binding]; other site
696281002839	Uncharacterized conserved protein [Function unknown]; Region: COG2461
696281002840	Family of unknown function (DUF438); Region: DUF438; pfam04282
696281002841	Hemerythrin-like domain; Region: Hr-like; cd12108
696281002842	Sm and related proteins; Region: Sm_like; cl00259
696281002843	heptamer interface [polypeptide binding]; other site
696281002844	Sm1 motif; other site
696281002845	hexamer interface [polypeptide binding]; other site
696281002846	RNA binding site [nucleotide binding]; other site
696281002847	Sm2 motif; other site
696281002848	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
696281002849	Arylsulfatase regulator (Fe-S oxidoreductase) [General function prediction only]; Region: AslB; COG0641
696281002850	FeS/SAM binding site; other site
696281002851	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
696281002852	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
696281002853	Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392
696281002854	sporulation sigma factor SigK; Reviewed; Region: PRK05803
696281002855	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
696281002856	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
696281002857	DNA binding residues [nucleotide binding]
696281002858	Protein of unknown function (DUF502); Region: DUF502; cl01107
696281002859	Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385
696281002860	Sodium Bile acid symporter family; Region: SBF; cl17470
696281002861	Transposase domain (DUF772); Region: DUF772; pfam05598
696281002862	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
696281002863	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
696281002864	DNA polymerase IV; Reviewed; Region: PRK03103
696281002865	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
696281002866	active site
696281002867	DNA binding site [nucleotide binding]
696281002868	Domain of unknown function (DUF4113); Region: DUF4113; pfam13438
696281002869	antitoxin MqsA for MqsR toxin; Region: MqsA; cl15819
696281002870	Zn binding site [ion binding]; other site
696281002871	toxin interface [polypeptide binding]; other site
696281002872	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
696281002873	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
696281002874	gluconate 5-dehydrogenase; Provisional; Region: PRK08213
696281002875	gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347
696281002876	NADP binding site [chemical binding]; other site
696281002877	homodimer interface [polypeptide binding]; other site
696281002878	active site
696281002879	DNA topoisomerase I, archaeal; Region: topA_arch; TIGR01057
696281002880	histidinol-phosphatase; Provisional; Region: PRK07328
696281002881	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase of Hisj like; Region: PHP_HisPPase_Hisj_like; cd12110
696281002882	active site
696281002883	dimer interface [polypeptide binding]; other site
696281002884	Predicted membrane protein [Function unknown]; Region: COG4129
696281002885	Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081
696281002886	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
696281002887	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
696281002888	active site
696281002889	metal binding site [ion binding]; metal-binding site
696281002890	Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333
696281002891	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
696281002892	Protein of unknown function (DUF3006); Region: DUF3006; pfam11213
696281002893	Domain of unknown function (DUF378); Region: DUF378; pfam04070
696281002894	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
696281002895	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
696281002896	substrate binding pocket [chemical binding]; other site
696281002897	membrane-bound complex binding site; other site
696281002898	hinge residues; other site
696281002899	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
696281002900	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
696281002901	dimer interface [polypeptide binding]; other site
696281002902	conserved gate region; other site
696281002903	putative PBP binding loops; other site
696281002904	ABC-ATPase subunit interface; other site
696281002905	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
696281002906	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
696281002907	Walker A/P-loop; other site
696281002908	ATP binding site [chemical binding]; other site
696281002909	Q-loop/lid; other site
696281002910	ABC transporter signature motif; other site
696281002911	Walker B; other site
696281002912	D-loop; other site
696281002913	H-loop/switch region; other site
696281002914	DsrE/DsrF/DrsH-like family; Region: DrsE_2; pfam13686
696281002915	SirA-like protein; Region: SirA; pfam01206
696281002916	CPxP  motif; other site
696281002917	CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385
696281002918	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
696281002919	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
696281002920	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
696281002921	active site residue [active]
696281002922	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
696281002923	dimerization interface [polypeptide binding]; other site
696281002924	putative DNA binding site [nucleotide binding]; other site
696281002925	putative Zn2+ binding site [ion binding]; other site
696281002926	Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840
696281002927	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
696281002928	active site
696281002929	metal binding site [ion binding]; metal-binding site
696281002930	DNA binding site [nucleotide binding]
696281002931	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419
696281002932	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
696281002933	Walker A/P-loop; other site
696281002934	ATP binding site [chemical binding]; other site
696281002935	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
696281002936	Q-loop/lid; other site
696281002937	ABC transporter signature motif; other site
696281002938	Walker B; other site
696281002939	D-loop; other site
696281002940	H-loop/switch region; other site
696281002941	Protein of unknown function, DUF485; Region: DUF485; cl01231
696281002942	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
696281002943	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
696281002944	Na binding site [ion binding]; other site
696281002945	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
696281002946	active site
696281002947	catalytic site [active]
696281002948	substrate binding site [chemical binding]; other site
696281002949	FOG: CBS domain [General function prediction only]; Region: COG0517
696281002950	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with either the CAP_ED (cAMP receptor protein effector domain) family of transcription factors and the DUF294 domain or the PB1 (Phox and Bem1p) domain; Region: CBS_pair_CAP-ED_DUF294_PBI_assoc2; cd04800
696281002951	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
696281002952	metal binding triad; other site
696281002953	Putative nucleotidyltransferase substrate binding domain; Region: DUF294_C; pfam10335
696281002954	Branched-chain amino acid transport protein (AzlD); Region: AzlD; pfam05437
696281002955	Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296
696281002956	EamA-like transporter family; Region: EamA; pfam00892
696281002957	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
696281002958	EamA-like transporter family; Region: EamA; pfam00892
696281002959	ABC-type Co2+ transport system, permease component [Inorganic ion transport and metabolism]; Region: CbiM; cl00397
696281002960	Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891
696281002961	PDGLE domain; Region: PDGLE; pfam13190
696281002962	cobalt ABC transporter, permease protein CbiQ; Region: CbiQ_TIGR; TIGR02454
696281002963	cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13647
696281002964	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
696281002965	Walker A/P-loop; other site
696281002966	ATP binding site [chemical binding]; other site
696281002967	Q-loop/lid; other site
696281002968	ABC transporter signature motif; other site
696281002969	Walker B; other site
696281002970	D-loop; other site
696281002971	H-loop/switch region; other site
696281002972	Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668
696281002973	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153
696281002974	Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102
696281002975	PHP family phosphoesterase with a Zn ribbon [General function prediction only]; Region: COG1379
696281002976	active site
696281002977	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
696281002978	Part of AAA domain; Region: AAA_19; pfam13245
696281002979	Family description; Region: UvrD_C_2; pfam13538
696281002980	polyphosphate:AMP phosphotransferase; Region: poly_P_AMP_trns; TIGR03708
696281002981	Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971
696281002982	Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971
696281002983	Neurexophilin; Region: Neurexophilin; pfam06312
696281002984	trigger factor; Provisional; Region: tig; PRK01490
696281002985	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
696281002986	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
696281002987	Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740
696281002988	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
696281002989	oligomer interface [polypeptide binding]; other site
696281002990	active site residues [active]
696281002991	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
696281002992	ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689
696281002993	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
696281002994	Walker A motif; other site
696281002995	ATP binding site [chemical binding]; other site
696281002996	Walker B motif; other site
696281002997	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
696281002998	ATP-dependent protease LonB; Region: spore_lonB; TIGR02902
696281002999	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
696281003000	Walker A motif; other site
696281003001	ATP binding site [chemical binding]; other site
696281003002	Walker B motif; other site
696281003003	arginine finger; other site
696281003004	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
696281003005	ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466
696281003006	Found in ATP-dependent protease La (LON); Region: LON; smart00464
696281003007	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
696281003008	Walker A motif; other site
696281003009	ATP binding site [chemical binding]; other site
696281003010	Walker B motif; other site
696281003011	arginine finger; other site
696281003012	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
696281003013	YihA (EngB) GTPase family; Region: YihA_EngB; cd01876
696281003014	Elongation factor Tu GTP binding domain; Region: GTP_EFTU; pfam00009
696281003015	G1 box; other site
696281003016	GTP/Mg2+ binding site [chemical binding]; other site
696281003017	Switch I region; other site
696281003018	G2 box; other site
696281003019	G3 box; other site
696281003020	Switch II region; other site
696281003021	G4 box; other site
696281003022	G5 box; other site
696281003023	Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644
696281003024	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
696281003025	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
696281003026	Protein of unknown function (DUF3792); Region: DUF3792; pfam12670
696281003027	valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729
696281003028	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
696281003029	HIGH motif; other site
696281003030	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
696281003031	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
696281003032	active site
696281003033	KMSKS motif; other site
696281003034	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
696281003035	tRNA binding surface [nucleotide binding]; other site
696281003036	anticodon binding site; other site
696281003037	Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458
696281003038	Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681
696281003039	Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285
696281003040	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
696281003041	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
696281003042	redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472
696281003043	Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971
696281003044	CoA binding domain; Region: CoA_binding; smart00881
696281003045	Maf-like protein; Reviewed; Region: PRK00078
696281003046	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
696281003047	active site
696281003048	dimer interface [polypeptide binding]; other site
696281003049	hypothetical protein; Reviewed; Region: PRK00024
696281003050	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
696281003051	MPN+ (JAMM) motif; other site
696281003052	Zinc-binding site [ion binding]; other site
696281003053	rod shape-determining protein MreB; Provisional; Region: PRK13927
696281003054	MreB and similar proteins; Region: MreB_like; cd10225
696281003055	nucleotide binding site [chemical binding]; other site
696281003056	Mg binding site [ion binding]; other site
696281003057	putative protofilament interaction site [polypeptide binding]; other site
696281003058	RodZ interaction site [polypeptide binding]; other site
696281003059	rod shape-determining protein MreC; Provisional; Region: PRK13922
696281003060	rod shape-determining protein MreC; Region: MreC; pfam04085
696281003061	rod shape-determining protein MreD; Region: shape_MreD; TIGR03426
696281003062	penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423
696281003063	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
696281003064	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
696281003065	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
696281003066	Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775
696281003067	septum site-determining protein MinD; Region: minD_bact; TIGR01968
696281003068	Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036
696281003069	Switch I; other site
696281003070	Switch II; other site
696281003071	Septum formation topological specificity factor MinE; Region: MinE; cl00538
696281003072	rod shape-determining protein RodA; Region: rodA_shape; TIGR02210
696281003073	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
696281003074	Peptidase family M23; Region: Peptidase_M23; pfam01551
696281003075	SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. SpoIVFB (sporulation protein, stage IV cell wall formation, F...; Region: S2P-M50_SpoIVFB; cd06161
696281003076	active site
696281003077	putative substrate binding region [chemical binding]; other site
696281003078	radical SAM family uncharacterized protein; Region: rSAM_fuse_unch; TIGR03960
696281003079	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
696281003080	B12 binding site [chemical binding]; other site
696281003081	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
696281003082	FeS/SAM binding site; other site
696281003083	radical SAM-linked protein; Region: sam_1_link_chp; TIGR03936
696281003084	Uncharacterized protein conserved in bacteria (DUF2344); Region: DUF2344; pfam10105
696281003085	ribonuclease G; Provisional; Region: PRK11712
696281003086	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
696281003087	homodimer interface [polypeptide binding]; other site
696281003088	oligonucleotide binding site [chemical binding]; other site
696281003089	TRAM domain; Region: TRAM; cl01282
696281003090	50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278
696281003091	50S ribosomal protein L21; Validated; Region: rplU; PRK05573
696281003092	50S ribosomal protein L27; Validated; Region: rpmA; PRK05435
696281003093	Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290
696281003094	GTPase CgtA; Reviewed; Region: obgE; PRK12297
696281003095	GTP1/OBG; Region: GTP1_OBG; pfam01018
696281003096	Obg GTPase; Region: Obg; cd01898
696281003097	G1 box; other site
696281003098	GTP/Mg2+ binding site [chemical binding]; other site
696281003099	Switch I region; other site
696281003100	G2 box; other site
696281003101	G3 box; other site
696281003102	Switch II region; other site
696281003103	G4 box; other site
696281003104	G5 box; other site
696281003105	Domain of unknown function (DUF1967); Region: DUF1967; pfam09269
696281003106	DNA-binding protein, stimulates sugar fermentation [General function prediction only]; Region: SfsA; COG1489
696281003107	Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853
696281003108	Sporulation protein YtfJ (Spore_YtfJ); Region: Spore_YtfJ; cl01596
696281003109	heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525
696281003110	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
696281003111	Soluble P-type ATPase [General function prediction only]; Region: COG4087
696281003112	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
696281003113	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
696281003114	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690
696281003115	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
696281003116	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
696281003117	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
696281003118	motif II; other site
696281003119	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
696281003120	Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729
696281003121	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
696281003122	FeS/SAM binding site; other site
696281003123	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
696281003124	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
696281003125	Zn2+ binding site [ion binding]; other site
696281003126	Mg2+ binding site [ion binding]; other site
696281003127	Protein of unknown function (DUF342); Region: DUF342; pfam03961
696281003128	Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519
696281003129	Protein of unknown function (DUF998); Region: DUF998; pfam06197
696281003130	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
696281003131	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
696281003132	ligand binding site [chemical binding]; other site
696281003133	flexible hinge region; other site
696281003134	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
696281003135	putative switch regulator; other site
696281003136	non-specific DNA interactions [nucleotide binding]; other site
696281003137	DNA binding site [nucleotide binding]
696281003138	sequence specific DNA binding site [nucleotide binding]; other site
696281003139	putative cAMP binding site [chemical binding]; other site
696281003140	DNA ligase 1; Provisional; Region: PLN03113
696281003141	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
696281003142	Protein of unknown function (DUF1847); Region: DUF1847; cl02037
696281003143	FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275
696281003144	nucleotide binding site/active site [active]
696281003145	HIT family signature motif; other site
696281003146	catalytic residue [active]
696281003147	nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071
696281003148	Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165
696281003149	active site
696281003150	(T/H)XGH motif; other site
696281003151	RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399
696281003152	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
696281003153	Zn2+ binding site [ion binding]; other site
696281003154	Mg2+ binding site [ion binding]; other site
696281003155	iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090
696281003156	AMP-binding domain protein; Validated; Region: PRK08315
696281003157	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
696281003158	Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917
696281003159	acyl-activating enzyme (AAE) consensus motif; other site
696281003160	putative AMP binding site [chemical binding]; other site
696281003161	putative active site [active]
696281003162	putative CoA binding site [chemical binding]; other site
696281003163	leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
696281003164	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
696281003165	HIGH motif; other site
696281003166	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
696281003167	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
696281003168	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
696281003169	active site
696281003170	KMSKS motif; other site
696281003171	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
696281003172	tRNA binding surface [nucleotide binding]; other site
696281003173	hypothetical protein; Provisional; Region: PRK04164
696281003174	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
696281003175	Predicted membrane protein [Function unknown]; Region: COG2323
696281003176	SLBB domain; Region: SLBB; pfam10531
696281003177	comEA protein; Region: comE; TIGR01259
696281003178	Helix-hairpin-helix motif; Region: HHH; pfam00633
696281003179	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
696281003180	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
696281003181	N-acetyl-D-glucosamine binding site [chemical binding]; other site
696281003182	catalytic residue [active]
696281003183	Domain of unknown function (DUF4131); Region: DUF4131; pfam13567
696281003184	Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658
696281003185	Competence protein; Region: Competence; pfam03772
696281003186	Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333
696281003187	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
696281003188	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
696281003189	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
696281003190	non-specific DNA binding site [nucleotide binding]; other site
696281003191	salt bridge; other site
696281003192	sequence-specific DNA binding site [nucleotide binding]; other site
696281003193	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
696281003194	S-adenosylmethionine binding site [chemical binding]; other site
696281003195	Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974
696281003196	phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189
696281003197	Int/Topo IB signature motif; other site
696281003198	Domain of unknown function (DUF955); Region: DUF955; pfam06114
696281003199	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
696281003200	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
696281003201	non-specific DNA binding site [nucleotide binding]; other site
696281003202	salt bridge; other site
696281003203	sequence-specific DNA binding site [nucleotide binding]; other site
696281003204	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200
696281003205	non-specific DNA binding site [nucleotide binding]; other site
696281003206	salt bridge; other site
696281003207	sequence-specific DNA binding site [nucleotide binding]; other site
696281003208	Uncharacterized phage-encoded protein [Function unknown]; Region: COG3646
696281003209	Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; pfam09669
696281003210	Helix-turn-helix domain; Region: HTH_17; pfam12728
696281003211	Sporulation initiation factor Spo0A C terminal; Region: Spo0A_C; pfam08769
696281003212	Protein of unknown function (DUF2800); Region: DUF2800; pfam10926
696281003213	Protein of unknown function (DUF2815); Region: DUF2815; pfam10991
696281003214	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_A; cd08642
696281003215	active site
696281003216	DNA binding site [nucleotide binding]
696281003217	catalytic site [active]
696281003218	HNH endonuclease; Region: HNH_3; pfam13392
696281003219	Virulence-associated protein E; Region: VirE; pfam05272
696281003220	VRR-NUC domain; Region: VRR_NUC; pfam08774
696281003221	SNF2 family N-terminal domain; Region: SNF2_N; pfam00176
696281003222	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
696281003223	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351
696281003224	Phage terminase large subunit; Region: Terminase_3; cl12054
696281003225	Phage-related holin (Lysis protein) [General function prediction only]; Region: COG4824
696281003226	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
696281003227	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
696281003228	active site
696281003229	metal binding site [ion binding]; metal-binding site
696281003230	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
696281003231	Uncharacterized conserved protein [Function unknown]; Region: COG4127
696281003232	hypothetical protein; Provisional; Region: PRK02237
696281003233	hypothetical protein; Provisional; Region: PRK02237
696281003234	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
696281003235	Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107
696281003236	DNA binding residues [nucleotide binding]
696281003237	drug binding residues [chemical binding]; other site
696281003238	dimer interface [polypeptide binding]; other site
696281003239	Transcriptional regulator, effector-binding domain/component [Transcription / Signal transduction mechanisms]; Region: COG4978
696281003240	cardiolipin synthase; Region: bac_cardiolipin; TIGR04265
696281003241	Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110
696281003242	putative active site [active]
696281003243	catalytic site [active]
696281003244	catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112
696281003245	putative active site [active]
696281003246	catalytic site [active]
696281003247	Domain of unknown function (DUF4163); Region: DUF4163; pfam13739
696281003248	Protein of unknown function (DUF3298); Region: DUF3298; pfam11738
696281003249	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
696281003250	Methyltransferase domain; Region: Methyltransf_23; pfam13489
696281003251	Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226
696281003252	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
696281003253	S-adenosylmethionine binding site [chemical binding]; other site
696281003254	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: GT1_like_1; cd04950
696281003255	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
696281003256	putative homodimer interface [polypeptide binding]; other site
696281003257	Glycosyltransferase like family; Region: Glyco_tranf_2_5; pfam13712
696281003258	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
696281003259	Probable Catalytic site; other site
696281003260	metal-binding site
696281003261	Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027
696281003262	shikimate kinase; Reviewed; Region: aroK; PRK00131
696281003263	ligand-binding site [chemical binding]; other site
696281003264	Methyltransferase domain; Region: Methyltransf_24; pfam13578
696281003265	Methyltransferase domain; Region: Methyltransf_31; pfam13847
696281003266	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
696281003267	S-adenosylmethionine binding site [chemical binding]; other site
696281003268	dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254
696281003269	RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321
696281003270	NADP binding site [chemical binding]; other site
696281003271	active site
696281003272	putative substrate binding site [chemical binding]; other site
696281003273	dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfbC; COG1898
696281003274	G1P_TT_long represents the long form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_long; cd04189
696281003275	glucose-1-phosphate thymidylylransferase, long form; Region: rmlA_long; TIGR01208
696281003276	substrate binding site; other site
696281003277	metal-binding site
696281003278	Oligomer interface; other site
696281003279	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
696281003280	dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088
696281003281	dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246
696281003282	NAD binding site [chemical binding]; other site
696281003283	substrate binding site [chemical binding]; other site
696281003284	homodimer interface [polypeptide binding]; other site
696281003285	active site
696281003286	Protein of unknown function (DUF1444); Region: DUF1444; cl02011
696281003287	Domain of unknown function DUF77; Region: DUF77; pfam01910
696281003288	DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574
696281003289	DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144
696281003290	30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239
696281003291	Membrane protein of unknown function; Region: DUF360; cl00850
696281003292	stage II sporulation protein P; Region: spore_II_P; TIGR02867
696281003293	GTP-binding protein LepA; Provisional; Region: PRK05433
696281003294	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
696281003295	G1 box; other site
696281003296	putative GEF interaction site [polypeptide binding]; other site
696281003297	GTP/Mg2+ binding site [chemical binding]; other site
696281003298	Switch I region; other site
696281003299	G2 box; other site
696281003300	G3 box; other site
696281003301	Switch II region; other site
696281003302	G4 box; other site
696281003303	G5 box; other site
696281003304	lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699
696281003305	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
696281003306	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
696281003307	Coproporphyrinogen III oxidase and related Fe-S oxidoreductases [Coenzyme metabolism]; Region: HemN; COG0635
696281003308	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
696281003309	FeS/SAM binding site; other site
696281003310	HemN C-terminal domain; Region: HemN_C; pfam06969
696281003311	heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082
696281003312	Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444
696281003313	chaperonin families, type I and type II. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. There are 2 main chaperonin groups. The...; Region: chaperonin_type_I_II; cd00309
696281003314	thermosome, various subunits, archaeal; Region: thermosome_arch; TIGR02339
696281003315	ATP/Mg binding site [chemical binding]; other site
696281003316	ring oligomerisation interface [polypeptide binding]; other site
696281003317	hinge regions; other site
696281003318	stacking interactions; other site
696281003319	GrpE; Region: GrpE; pfam01025
696281003320	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
696281003321	dimer interface [polypeptide binding]; other site
696281003322	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
696281003323	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
696281003324	Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234
696281003325	nucleotide binding site [chemical binding]; other site
696281003326	NEF interaction site [polypeptide binding]; other site
696281003327	SBD interface [polypeptide binding]; other site
696281003328	chaperone protein DnaJ; Provisional; Region: PRK10767
696281003329	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
696281003330	HSP70 interaction site [polypeptide binding]; other site
696281003331	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262
696281003332	substrate binding site [polypeptide binding]; other site
696281003333	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
696281003334	Zn binding sites [ion binding]; other site
696281003335	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
696281003336	dimer interface [polypeptide binding]; other site
696281003337	ribosomal protein L11 methyltransferase; Reviewed; Region: prmA; PRK00517
696281003338	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
696281003339	S-adenosylmethionine binding site [chemical binding]; other site
696281003340	16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713
696281003341	RNA methyltransferase, RsmE family; Region: TIGR00046
696281003342	2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621
696281003343	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
696281003344	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
696281003345	FeS/SAM binding site; other site
696281003346	Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276
696281003347	nucleotide binding site/active site [active]
696281003348	HIT family signature motif; other site
696281003349	catalytic residue [active]
696281003350	30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270
696281003351	Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030
696281003352	hypothetical protein; Provisional; Region: PRK13665
696281003353	YabP family; Region: YabP; cl06766
696281003354	Putative stage IV sporulation protein YqfD; Region: YqfD; pfam06898
696281003355	sporulation protein YqfD; Region: spore_yqfD; TIGR02876
696281003356	Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702
696281003357	PhoH-like protein; Region: PhoH; pfam02562
696281003358	Predicted membrane-associated HD superfamily hydrolase [General function prediction only]; Region: COG1480
696281003359	7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698
696281003360	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
696281003361	Zn2+ binding site [ion binding]; other site
696281003362	Mg2+ binding site [ion binding]; other site
696281003363	metal-binding heat shock protein; Provisional; Region: PRK00016
696281003364	Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; pfam01219
696281003365	Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283
696281003366	active site
696281003367	catalytic motif [active]
696281003368	Zn binding site [ion binding]; other site
696281003369	GTPase Era; Reviewed; Region: era; PRK00089
696281003370	E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163
696281003371	G1 box; other site
696281003372	GTP/Mg2+ binding site [chemical binding]; other site
696281003373	Switch I region; other site
696281003374	G2 box; other site
696281003375	Switch II region; other site
696281003376	G3 box; other site
696281003377	G4 box; other site
696281003378	G5 box; other site
696281003379	KH domain; Region: KH_2; pfam07650
696281003380	Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239
696281003381	MgtE intracellular N domain; Region: MgtE_N; pfam03448
696281003382	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE.  MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606
696281003383	Divalent cation transporter; Region: MgtE; pfam01769
696281003384	3-polyprenyl-4-hydroxybenzoate decarboxylase [Coenzyme metabolism]; Region: UbiX; COG0163
696281003385	Flavoprotein; Region: Flavoprotein; pfam02441
696281003386	DNA repair protein RecO; Reviewed; Region: recO; PRK00085
696281003387	Recombination protein O N terminal; Region: RecO_N; pfam11967
696281003388	Recombination protein O C terminal; Region: RecO_C; pfam02565
696281003389	Domain of unknown function (DUF4342); Region: DUF4342; pfam14242
696281003390	Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733
696281003391	dimer interface [polypeptide binding]; other site
696281003392	motif 1; other site
696281003393	active site
696281003394	motif 2; other site
696281003395	motif 3; other site
696281003396	glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233
696281003397	DALR anticodon binding domain; Region: DALR_1; pfam05746
696281003398	HTH domain; Region: HTH_11; pfam08279
696281003399	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
696281003400	Kinase/pyrophosphorylase; Region: Kinase-PPPase; pfam03618
696281003401	pyruvate phosphate dikinase; Provisional; Region: PRK09279
696281003402	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
696281003403	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
696281003404	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
696281003405	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604
696281003406	2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258
696281003407	LigT like Phosphoesterase; Region: LigT_PEase; pfam02834
696281003408	Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655
696281003409	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
696281003410	deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01286
696281003411	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
696281003412	Zn2+ binding site [ion binding]; other site
696281003413	Mg2+ binding site [ion binding]; other site
696281003414	Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286
696281003415	DNA primase; Validated; Region: dnaG; PRK05667
696281003416	CHC2 zinc finger; Region: zf-CHC2; pfam01807
696281003417	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
696281003418	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
696281003419	active site
696281003420	metal binding site [ion binding]; metal-binding site
696281003421	interdomain interaction site; other site
696281003422	RNA polymerase sigma factor RpoD; Validated; Region: PRK09210
696281003423	Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979
696281003424	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
696281003425	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
696281003426	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
696281003427	DNA binding residues [nucleotide binding]
696281003428	CRISPR/Cas system-associated RAMP superfamily protein Cmr1; Region: Cmr1_III-B; cl17436
696281003429	CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cl17214
696281003430	CRISPR/Cas system-associated protein Cas10; Region: Cas10_III; cd09701
696281003431	CRISPR-associated protein, Csx11 family; Region: cas_csx11; TIGR02682
696281003432	CRISPR/Cas system-associated RAMP superfamily protein Cmr4; Region: Cmr4_III-B; cl17440
696281003433	SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966
696281003434	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
696281003435	dimerization interface [polypeptide binding]; other site
696281003436	Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015
696281003437	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
696281003438	dimer interface [polypeptide binding]; other site
696281003439	putative CheW interface [polypeptide binding]; other site
696281003440	Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384
696281003441	Family of unknown function (DUF633); Region: DUF633; pfam04816
696281003442	Uncharacterized conserved protein [Function unknown]; Region: COG0327
696281003443	NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784
696281003444	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323
696281003445	Uncharacterized conserved protein [Function unknown]; Region: COG0327
696281003446	NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784
696281003447	Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579
696281003448	Putative zinc ribbon domain; Region: DUF164; pfam02591
696281003449	oligoendopeptidase F; Region: pepF; TIGR00181
696281003450	Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608
696281003451	active site
696281003452	Zn binding site [ion binding]; other site
696281003453	D-cysteine desulfhydrase; Validated; Region: PRK03910
696281003454	Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342
696281003455	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
696281003456	catalytic residue [active]
696281003457	RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278
696281003458	RNA/DNA hybrid binding site [nucleotide binding]; other site
696281003459	active site
696281003460	metallo-beta-lactamase/flavodoxin domain-containing protein; Provisional; Region: PRK11921
696281003461	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
696281003462	Flavodoxin; Region: Flavodoxin_1; pfam00258
696281003463	Flavin reductase like domain; Region: Flavin_Reduct; pfam01613
696281003464	Rubredoxin, Small Modular nonheme iron binding domain containing a [Fe(SCys)4] center, present in rubrerythrin and nigerythrin and detected either N- or C-terminal to such proteins as flavin reductase, NAD(P)H-nitrite reductase, and...; Region: rubredoxin_SM; cd00729
696281003465	Rubredoxin; Region: Rubredoxin; pfam00301
696281003466	iron binding site [ion binding]; other site
696281003467	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
696281003468	The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493
696281003469	peptide binding site [polypeptide binding]; other site
696281003470	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
696281003471	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
696281003472	dimer interface [polypeptide binding]; other site
696281003473	conserved gate region; other site
696281003474	putative PBP binding loops; other site
696281003475	ABC-ATPase subunit interface; other site
696281003476	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
696281003477	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
696281003478	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
696281003479	dimer interface [polypeptide binding]; other site
696281003480	conserved gate region; other site
696281003481	putative PBP binding loops; other site
696281003482	ABC-ATPase subunit interface; other site
696281003483	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
696281003484	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
696281003485	Walker A/P-loop; other site
696281003486	ATP binding site [chemical binding]; other site
696281003487	Q-loop/lid; other site
696281003488	ABC transporter signature motif; other site
696281003489	Walker B; other site
696281003490	D-loop; other site
696281003491	H-loop/switch region; other site
696281003492	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
696281003493	dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308
696281003494	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
696281003495	Walker A/P-loop; other site
696281003496	ATP binding site [chemical binding]; other site
696281003497	Q-loop/lid; other site
696281003498	ABC transporter signature motif; other site
696281003499	Walker B; other site
696281003500	D-loop; other site
696281003501	H-loop/switch region; other site
696281003502	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
696281003503	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
696281003504	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
696281003505	metal binding site [ion binding]; metal-binding site
696281003506	active site
696281003507	I-site; other site
696281003508	pyrophosphatase PpaX; Provisional; Region: PRK13288
696281003509	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
696281003510	motif II; other site
696281003511	acyl-CoA synthetase; Validated; Region: PRK07868
696281003512	The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425
696281003513	active site
696281003514	8-oxo-dGMP binding site [chemical binding]; other site
696281003515	nudix motif; other site
696281003516	metal binding site [ion binding]; metal-binding site
696281003517	2-phosphosulfolactate phosphatase; Provisional; Region: PRK00886
696281003518	Phosphosulfolactate phosphohydrolase and related enzymes [Coenzyme metabolism / General function prediction only]; Region: COG2045
696281003519	Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291
696281003520	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
696281003521	flagellar motor protein MotD; Reviewed; Region: PRK09038
696281003522	Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677
696281003523	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
696281003524	ligand binding site [chemical binding]; other site
696281003525	CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732
696281003526	putative CheA interaction surface; other site
696281003527	Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643
696281003528	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
696281003529	putative binding surface; other site
696281003530	active site
696281003531	P2 response regulator binding domain; Region: P2; pfam07194
696281003532	Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895
696281003533	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
696281003534	ATP binding site [chemical binding]; other site
696281003535	Mg2+ binding site [ion binding]; other site
696281003536	G-X-G motif; other site
696281003537	CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731
696281003538	chemotaxis-specific methylesterase; Provisional; Region: PRK00742
696281003539	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
696281003540	active site
696281003541	phosphorylation site [posttranslational modification]
696281003542	intermolecular recognition site; other site
696281003543	dimerization interface [polypeptide binding]; other site
696281003544	CheB methylesterase; Region: CheB_methylest; pfam01339
696281003545	flagellar biosynthesis anti-sigma factor FlgM; Region: FlgM_jcvi; TIGR03824
696281003546	FlgN protein; Region: FlgN; pfam05130
696281003547	flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK07739
696281003548	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
696281003549	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
696281003550	flagellar hook-associated protein FlgL; Validated; Region: flgL; PRK07701
696281003551	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
696281003552	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
696281003553	flagellin; Provisional; Region: PRK12804
696281003554	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
696281003555	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2604
696281003556	UDP-N-acetylglucosamine 4,6-dehydratase; Region: PseB; TIGR03589
696281003557	UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237
696281003558	NAD(P) binding site [chemical binding]; other site
696281003559	homodimer interface [polypeptide binding]; other site
696281003560	substrate binding site [chemical binding]; other site
696281003561	active site
696281003562	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
696281003563	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
696281003564	inhibitor-cofactor binding pocket; inhibition site
696281003565	pyridoxal 5'-phosphate binding site [chemical binding]; other site
696281003566	catalytic residue [active]
696281003567	SpsF is a glycosyltrnasferase implicated in the synthesis of the spore coat; Region: GT2_SpsF; cd02518
696281003568	ligand binding site; other site
696281003569	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
696281003570	pseudaminic acid biosynthesis-associated protein PseG; Region: PseG; TIGR03590
696281003571	Glycosyltransferase family 28 C-terminal domain; Region: Glyco_tran_28_C; cl17369
696281003572	pseudaminic acid biosynthesis N-acetyl transferase; Region: PseH; TIGR03585
696281003573	Uncharacterized proteins, LmbE homologs [Function unknown]; Region: COG2120
696281003574	pseudaminic acid synthase; Region: PseI; TIGR03586
696281003575	NeuB family; Region: NeuB; pfam03102
696281003576	C-terminal SAF domain of sialic acid synthetase; Region: SAF_NeuB_like; cd11615
696281003577	NeuB binding interface [polypeptide binding]; other site
696281003578	putative substrate binding site [chemical binding]; other site
696281003579	Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465
696281003580	Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195
696281003581	Global regulator protein family; Region: CsrA; pfam02599
696281003582	FliW protein; Region: FliW; cl00740
696281003583	Flagellar protein FliS; Region: FliS; cl00654
696281003584	Flagellar protein FliT; Region: FliT; cl05125
696281003585	FlaG protein; Region: FlaG; pfam03646
696281003586	Protein of unknown function DUF86; Region: DUF86; pfam01934
696281003587	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
696281003588	active site
696281003589	NTP binding site [chemical binding]; other site
696281003590	metal binding triad [ion binding]; metal-binding site
696281003591	antibiotic binding site [chemical binding]; other site
696281003592	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
696281003593	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
696281003594	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
696281003595	catalytic residue [active]
696281003596	Flagellar basal body protein [Cell motility and secretion]; Region: FlgB; COG1815
696281003597	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
696281003598	flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182
696281003599	flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681
696281003600	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
696281003601	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
696281003602	Flagellar hook-basal body complex protein FliE; Region: FliE; pfam02049
696281003603	flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007
696281003604	Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907
696281003605	Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345
696281003606	flagellar motor switch protein G; Validated; Region: fliG; PRK05686
696281003607	FliG C-terminal domain; Region: FliG_C; pfam01706
696281003608	type III secretion apparatus protein, HrpE/YscL family; Region: HrpE_YscL_not; TIGR02499
696281003609	ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192
696281003610	Flagellar assembly protein FliH; Region: FliH; pfam02108
696281003611	flagellar protein export ATPase FliI; Region: FliI_clade2; TIGR03497
696281003612	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
696281003613	Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136
696281003614	Walker A motif/ATP binding site; other site
696281003615	Walker B motif; other site
696281003616	flagellar export protein FliJ; Region: flagell_FliJ; TIGR02473
696281003617	Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120
696281003618	Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963
696281003619	flagellar basal body rod modification protein; Provisional; Region: flgD; PRK09618
696281003620	Protein of unknown function (DUF3766); Region: DUF3766; cl11797
696281003621	flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12636
696281003622	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
696281003623	Fascin-like domain; members include actin-bundling/crosslinking proteins facsin, histoactophilin and singed;  identified in sea urchin, Drosophila, Xenopus, rodents, and humans; The fascin-like domain adopts a beta-trefoil topology and contains an...; Region: Fascin; cl00187
696281003624	PKC phosphorylation site [posttranslational modification]; other site
696281003625	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
696281003626	Flagellar basal body-associated protein FliL; Region: FliL; pfam03748
696281003627	Flagellar motor switch/type III secretory pathway protein [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliN; COG1886
696281003628	Flagellar biosynthesis protein, FliO; Region: FliO; pfam04347
696281003629	flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699
696281003630	flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700
696281003631	flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701
696281003632	flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702
696281003633	Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257
696281003634	flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012
696281003635	FHIPEP family; Region: FHIPEP; pfam00771
696281003636	flagellar biosynthesis regulator FlhF; Validated; Region: flhF; PRK05703
696281003637	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
696281003638	Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455
696281003639	FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038
696281003640	P-loop; other site
696281003641	c-di-GMP-binding protein [Signal transduction mechanisms]; Region: COG5581
696281003642	Flagellar protein YcgR; Region: YcgR_2; pfam12945
696281003643	PilZ domain; Region: PilZ; pfam07238
696281003644	RNA polymerase sigma factor WhiG; Reviewed; Region: PRK06288
696281003645	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
696281003646	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
696281003647	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
696281003648	DNA binding residues [nucleotide binding]
696281003649	Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgG; COG4786
696281003650	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
696281003651	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
696281003652	flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693
696281003653	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
696281003654	flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490
696281003655	CheD chemotactic sensory transduction; Region: CheD; cl00810
696281003656	Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352
696281003657	CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705
696281003658	CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739
696281003659	Chemotaxis protein CheC, inhibitor of MCP methylation [Cell motility and secretion / Signal transduction mechanisms]; Region: CheC; COG1776
696281003660	CheC-like family; Region: CheC; pfam04509
696281003661	CheC-like family; Region: CheC; pfam04509
696281003662	Response regulator receiver domain; Region: Response_reg; pfam00072
696281003663	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
696281003664	active site
696281003665	phosphorylation site [posttranslational modification]
696281003666	intermolecular recognition site; other site
696281003667	dimerization interface [polypeptide binding]; other site
696281003668	flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666
696281003669	Surface presentation of antigens (SPOA); Region: SpoA; pfam01052
696281003670	flagellar motor switch protein; Validated; Region: PRK08119
696281003671	CheC-like family; Region: CheC; pfam04509
696281003672	CheC-like family; Region: CheC; pfam04509
696281003673	Surface presentation of antigens (SPOA); Region: SpoA; cl00819
696281003674	Protein of unknown function (DUF1015); Region: DUF1015; pfam06245
696281003675	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain putative pyrophosphatase YpjD from Bacillus subtilis and its bacterial homologs; Region: NTP-PPase_BsYpjD; cd11531
696281003676	homodimer interface [polypeptide binding]; other site
696281003677	metal binding site [ion binding]; metal-binding site
696281003678	Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065
696281003679	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
696281003680	active site
696281003681	GMP synthase; Reviewed; Region: guaA; PRK00074
696281003682	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
696281003683	AMP/PPi binding site [chemical binding]; other site
696281003684	candidate oxyanion hole; other site
696281003685	catalytic triad [active]
696281003686	potential glutamine specificity residues [chemical binding]; other site
696281003687	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
696281003688	ATP Binding subdomain [chemical binding]; other site
696281003689	Ligand Binding sites [chemical binding]; other site
696281003690	Dimerization subdomain; other site
696281003691	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
696281003692	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
696281003693	AIR carboxylase; Region: AIRC; pfam00731
696281003694	adenylosuccinate lyase; Provisional; Region: PRK07492
696281003695	Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360
696281003696	tetramer interface [polypeptide binding]; other site
696281003697	active site
696281003698	Adenylosuccinate lyase C-terminus; Region: ADSL_C; smart00998
696281003699	phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362
696281003700	bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415
696281003701	ATP binding site [chemical binding]; other site
696281003702	active site
696281003703	substrate binding site [chemical binding]; other site
696281003704	Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; pfam02700
696281003705	phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619
696281003706	Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
696281003707	putative active site [active]
696281003708	catalytic triad [active]
696281003709	phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213
696281003710	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203
696281003711	dimerization interface [polypeptide binding]; other site
696281003712	ATP binding site [chemical binding]; other site
696281003713	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204
696281003714	dimerization interface [polypeptide binding]; other site
696281003715	ATP binding site [chemical binding]; other site
696281003716	amidophosphoribosyltransferase; Provisional; Region: PRK05793
696281003717	Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of  glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715
696281003718	active site
696281003719	tetramer interface [polypeptide binding]; other site
696281003720	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
696281003721	active site
696281003722	phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385
696281003723	PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196
696281003724	dimerization interface [polypeptide binding]; other site
696281003725	putative ATP binding site [chemical binding]; other site
696281003726	phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647
696281003727	Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645
696281003728	active site
696281003729	substrate binding site [chemical binding]; other site
696281003730	cosubstrate binding site; other site
696281003731	catalytic site [active]
696281003732	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881
696281003733	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates...; Region: IMPCH; cd01421
696281003734	purine monophosphate binding site [chemical binding]; other site
696281003735	dimer interface [polypeptide binding]; other site
696281003736	putative catalytic residues [active]
696281003737	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798
696281003738	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362
696281003739	phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885
696281003740	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
696281003741	Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071
696281003742	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
696281003743	Trp repressor protein; Region: Trp_repressor; cl17266
696281003744	ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12292
696281003745	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
696281003746	dimer interface [polypeptide binding]; other site
696281003747	motif 1; other site
696281003748	active site
696281003749	motif 2; other site
696281003750	motif 3; other site
696281003751	ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686
696281003752	ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040
696281003753	Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572
696281003754	histidinol dehydrogenase; Region: hisD; TIGR00069
696281003755	NAD binding site [chemical binding]; other site
696281003756	dimerization interface [polypeptide binding]; other site
696281003757	product binding site; other site
696281003758	substrate binding site [chemical binding]; other site
696281003759	zinc binding site [ion binding]; other site
696281003760	catalytic residues [active]
696281003761	histidinol-phosphate aminotransferase; Region: hisC; TIGR01141
696281003762	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
696281003763	pyridoxal 5'-phosphate binding site [chemical binding]; other site
696281003764	homodimer interface [polypeptide binding]; other site
696281003765	catalytic residue [active]
696281003766	Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914
696281003767	putative active site pocket [active]
696281003768	4-fold oligomerization interface [polypeptide binding]; other site
696281003769	metal binding residues [ion binding]; metal-binding site
696281003770	3-fold/trimer interface [polypeptide binding]; other site
696281003771	imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141
696281003772	Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748
696281003773	putative active site [active]
696281003774	oxyanion strand; other site
696281003775	catalytic triad [active]
696281003776	HisA.  Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732
696281003777	phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007
696281003778	catalytic residues [active]
696281003779	The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731
696281003780	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
696281003781	substrate binding site [chemical binding]; other site
696281003782	glutamase interaction surface [polypeptide binding]; other site
696281003783	phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051
696281003784	bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759
696281003785	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534
696281003786	metal binding site [ion binding]; metal-binding site
696281003787	Reovirus sigma C capsid protein; Region: Reo_sigmaC; pfam04582
696281003788	ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073
696281003789	Part of AAA domain; Region: AAA_19; pfam13245
696281003790	Family description; Region: UvrD_C_2; pfam13538
696281003791	Protein of unknown function (DUF2837); Region: DUF2837; pfam10997
696281003792	NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956
696281003793	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
696281003794	nucleotide binding pocket [chemical binding]; other site
696281003795	K-X-D-G motif; other site
696281003796	catalytic site [active]
696281003797	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
696281003798	NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119
696281003799	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
696281003800	Dimer interface [polypeptide binding]; other site
696281003801	BRCT sequence motif; other site
696281003802	PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493
696281003803	Trp docking motif [polypeptide binding]; other site
696281003804	active site
696281003805	PQQ-like domain; Region: PQQ_2; pfam13360
696281003806	S-layer homology domain; Region: SLH; pfam00395
696281003807	S-layer homology domain; Region: SLH; pfam00395
696281003808	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
696281003809	homotrimer interaction site [polypeptide binding]; other site
696281003810	putative active site [active]
696281003811	aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034
696281003812	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
696281003813	aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012
696281003814	aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477
696281003815	GatB/GatE catalytic domain; Region: GatB_N; pfam02934
696281003816	GatB domain; Region: GatB_Yqey; smart00845
696281003817	trans-homoaconitate synthase; Reviewed; Region: aksA; PRK11858
696281003818	Streptomyces rubellomurinus FrbC and related proteins, catalytic TIM barrel domain; Region: DRE_TIM_NifV; cd07939
696281003819	active site
696281003820	catalytic residues [active]
696281003821	metal binding site [ion binding]; metal-binding site
696281003822	3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
696281003823	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
696281003824	substrate binding site [chemical binding]; other site
696281003825	ligand binding site [chemical binding]; other site
696281003826	3-isopropylmalate dehydratase small subunit; Reviewed; Region: leuD; PRK00439
696281003827	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
696281003828	substrate binding site [chemical binding]; other site
696281003829	Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473
696281003830	tartrate dehydrogenase; Region: TTC; TIGR02089
696281003831	Methyltransferase domain; Region: Methyltransf_31; pfam13847
696281003832	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
696281003833	S-adenosylmethionine binding site [chemical binding]; other site
696281003834	Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196
696281003835	Phage tail sheath protein; Region: Phage_sheath_1; pfam04984
696281003836	Protein of unknown function (DUF2001); Region: DUF2001; pfam09393
696281003837	Phage XkdN-like protein; Region: XkdN; pfam08890
696281003838	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
696281003839	Protein of unknown function (DUF2577); Region: DUF2577; pfam10844
696281003840	Protein of unknown function (DUF2634); Region: DUF2634; pfam10934
696281003841	Uncharacterized homolog of phage Mu protein gp47 [Function unknown]; Region: XkdT; COG3299
696281003842	Uncharacterized protein conserved in bacteria (DUF2313); Region: DUF2313; cl01542
696281003843	Phage uncharacterized protein (Phage_XkdX); Region: Phage_XkdX; pfam09693
696281003844	Carbohydrate binding domain; Region: CBM_25; smart01066
696281003845	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
696281003846	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
696281003847	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
696281003848	NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181
696281003849	active site
696281003850	Substrate binding site; other site
696281003851	Mg++ binding site; other site
696281003852	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
696281003853	putative trimer interface [polypeptide binding]; other site
696281003854	putative CoA binding site [chemical binding]; other site
696281003855	phosphoglucosamine mutase; Region: Arch_GlmM; TIGR03990
696281003856	GTP-mannose-1-phosphate guanyltransferase (MPG1 transferase), also known as GDP-mannose pyrophosphorylase, is a bifunctional enzyme with both phosphomannose isomerase (PMI) activity and GDP-mannose phosphorylase (GMP) activity.  The protein contains an...; Region: MPG1_transferase; cd05805
696281003857	Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain [General function prediction only]; Region: COG2872
696281003858	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
696281003859	Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219
696281003860	Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177
696281003861	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
696281003862	minor groove reading motif; other site
696281003863	helix-hairpin-helix signature motif; other site
696281003864	substrate binding pocket [chemical binding]; other site
696281003865	active site
696281003866	Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576
696281003867	Predicted CoA-binding protein [General function prediction only]; Region: COG1832
696281003868	Membrane protein of unknown function (DUF340); Region: DUF340; cl01028
696281003869	Membrane protein of unknown function (DUF340); Region: DUF340; pfam03956
696281003870	CAAX protease self-immunity; Region: Abi; pfam02517
696281003871	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3330
696281003872	Uncharacterized conserved protein [Function unknown]; Region: COG1543
696281003873	N-terminal catalytic domain of  alpha-amylase ( AmyC ) and similar proteins; Region: GH57N_AmyC_like; cd10792
696281003874	active site
696281003875	substrate binding site [chemical binding]; other site
696281003876	catalytic site [active]
696281003877	Domain of unknown function (DUF1957); Region: DUF1957; pfam09210
696281003878	bacillithiol biosynthesis deacetylase BshB1; Region: thiol_BshB1; TIGR04001
696281003879	N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA; Region: thiol_BshA; TIGR03999
696281003880	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_5; cd04962
696281003881	Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992
696281003882	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
696281003883	NlpC/P60 family; Region: NLPC_P60; pfam00877
696281003884	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1655
696281003885	Uncharacterized protein conserved in bacteria (DUF2225); Region: DUF2225; pfam09986
696281003886	DNA polymerase III DnaE; Reviewed; Region: dnaE; PRK06826
696281003887	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113
696281003888	active site
696281003889	PHP Thumb interface [polypeptide binding]; other site
696281003890	metal binding site [ion binding]; metal-binding site
696281003891	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
696281003892	generic binding surface I; other site
696281003893	generic binding surface II; other site
696281003894	Cation transport protein; Region: TrkH; cl17365
696281003895	TrkA-C domain; Region: TrkA_C; pfam02080
696281003896	transcription attenuation protein MtrB; Provisional; Region: PRK13251
696281003897	acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654
696281003898	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
696281003899	acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724
696281003900	acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198
696281003901	6-phosphofructokinase; Provisional; Region: PRK03202
696281003902	6-phosphofructokinase; Region: PFKA_ATP; TIGR02482
696281003903	active site
696281003904	ADP/pyrophosphate binding site [chemical binding]; other site
696281003905	dimerization interface [polypeptide binding]; other site
696281003906	allosteric effector site; other site
696281003907	fructose-1,6-bisphosphate binding site; other site
696281003908	pyruvate kinase; Provisional; Region: PRK06354
696281003909	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
696281003910	domain interfaces; other site
696281003911	active site
696281003912	Phosphohistidine swiveling domain [Signal transduction mechanisms]; Region: COG3848
696281003913	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
696281003914	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
696281003915	Macro domain, a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases). Some macro domains recognize poly...; Region: Macro; cl00019
696281003916	Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_like_4; cd04501
696281003917	active site
696281003918	catalytic triad [active]
696281003919	oxyanion hole [active]
696281003920	anthranilate synthase component I, non-proteobacterial lineages; Region: trpE_most; TIGR00564
696281003921	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
696281003922	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
696281003923	para-aminobenzoate synthase component II; Provisional; Region: PRK08857
696281003924	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
696281003925	glutamine binding [chemical binding]; other site
696281003926	catalytic triad [active]
696281003927	anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188
696281003928	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
696281003929	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
696281003930	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
696281003931	active site
696281003932	ribulose/triose binding site [chemical binding]; other site
696281003933	phosphate binding site [ion binding]; other site
696281003934	substrate (anthranilate) binding pocket [chemical binding]; other site
696281003935	product (indole) binding pocket [chemical binding]; other site
696281003936	Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405
696281003937	active site
696281003938	tryptophan synthase, beta subunit; Region: trpB; TIGR00263
696281003939	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
696281003940	pyridoxal 5'-phosphate binding site [chemical binding]; other site
696281003941	catalytic residue [active]
696281003942	tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200
696281003943	Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724
696281003944	substrate binding site [chemical binding]; other site
696281003945	active site
696281003946	catalytic residues [active]
696281003947	heterodimer interface [polypeptide binding]; other site
696281003948	putative RNA polymerase sigma factor SigI; Reviewed; Region: PRK08311
696281003949	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
696281003950	Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598
696281003951	Thermotoga maritima CorA-like family; Region: TmCorA-like; cd12822
696281003952	oligomer interface [polypeptide binding]; other site
696281003953	metal binding site [ion binding]; metal-binding site
696281003954	metal binding site [ion binding]; metal-binding site
696281003955	putative Cl binding site [ion binding]; other site
696281003956	aspartate ring; other site
696281003957	basic sphincter; other site
696281003958	hydrophobic gate; other site
696281003959	periplasmic entrance; other site
696281003960	Iron only hydrogenase large subunit, C-terminal domain [General function prediction only]; Region: COG4624
696281003961	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
696281003962	Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906
696281003963	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
696281003964	dimerization interface [polypeptide binding]; other site
696281003965	putative DNA binding site [nucleotide binding]; other site
696281003966	putative Zn2+ binding site [ion binding]; other site
696281003967	Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016
696281003968	RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652
696281003969	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
696281003970	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
696281003971	DNA binding residues [nucleotide binding]
696281003972	Putative zinc-finger; Region: zf-HC2; pfam13490
696281003973	Domain of unknown function (DUF4349); Region: DUF4349; pfam14257
696281003974	Protein of unknown function (DUF972); Region: DUF972; pfam06156
696281003975	Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694
696281003976	NifU-like domain; Region: NifU; cl00484
696281003977	Transcriptional regulator [Transcription]; Region: LysR; COG0583
696281003978	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
696281003979	C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420
696281003980	putative dimerization interface [polypeptide binding]; other site
696281003981	Predicted amidohydrolase [General function prediction only]; Region: COG0388
696281003982	Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572
696281003983	putative active site [active]
696281003984	catalytic triad [active]
696281003985	dimer interface [polypeptide binding]; other site
696281003986	Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176
696281003987	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
696281003988	dimer interface [polypeptide binding]; other site
696281003989	active site
696281003990	metal binding site [ion binding]; metal-binding site
696281003991	Iron-containing alcohol dehydrogenases-like; Region: Fe-ADH4; cd08188
696281003992	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
696281003993	putative active site [active]
696281003994	metal binding site [ion binding]; metal-binding site
696281003995	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
696281003996	GAF domain; Region: GAF_3; pfam13492
696281003997	PAS fold; Region: PAS_4; pfam08448
696281003998	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
696281003999	dimer interface [polypeptide binding]; other site
696281004000	phosphorylation site [posttranslational modification]
696281004001	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
696281004002	ATP binding site [chemical binding]; other site
696281004003	G-X-G motif; other site
696281004004	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
696281004005	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
696281004006	active site
696281004007	phosphorylation site [posttranslational modification]
696281004008	intermolecular recognition site; other site
696281004009	dimerization interface [polypeptide binding]; other site
696281004010	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
696281004011	Walker A motif; other site
696281004012	ATP binding site [chemical binding]; other site
696281004013	Walker B motif; other site
696281004014	arginine finger; other site
696281004015	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
696281004016	Ubiquitin-like proteins; Region: UBQ; cl00155
696281004017	charged pocket; other site
696281004018	hydrophobic patch; other site
696281004019	Aldehyde ferredoxin oxidoreductase, N-terminal domain; Region: AFOR_N; pfam02730
696281004020	Aldehyde:ferredoxin oxidoreductase [Energy production and conversion]; Region: COG2414
696281004021	Aldehyde ferredoxin oxidoreductase, domains 2 & 3; Region: AFOR_C; pfam01314
696281004022	ThiS family; Region: ThiS; pfam02597
696281004023	charged pocket; other site
696281004024	hydrophobic patch; other site
696281004025	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
696281004026	dimer interface [polypeptide binding]; other site
696281004027	conserved gate region; other site
696281004028	putative PBP binding loops; other site
696281004029	ABC-ATPase subunit interface; other site
696281004030	sulfate ABC transporter, ATP-binding protein; Region: 3a0106s01; TIGR00968
696281004031	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
696281004032	Walker A/P-loop; other site
696281004033	ATP binding site [chemical binding]; other site
696281004034	Q-loop/lid; other site
696281004035	ABC transporter signature motif; other site
696281004036	Walker B; other site
696281004037	D-loop; other site
696281004038	H-loop/switch region; other site
696281004039	molybdenum cofactor biosynthesis protein A, bacterial; Region: moaA; TIGR02666
696281004040	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
696281004041	FeS/SAM binding site; other site
696281004042	Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463
696281004043	MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420
696281004044	trimer interface [polypeptide binding]; other site
696281004045	dimer interface [polypeptide binding]; other site
696281004046	putative active site [active]
696281004047	MOSC domain; Region: MOSC; pfam03473
696281004048	Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116
696281004049	Walker A motif; other site
696281004050	molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690
696281004051	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
696281004052	ATP binding site [chemical binding]; other site
696281004053	substrate interface [chemical binding]; other site
696281004054	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
696281004055	Major Facilitator Superfamily; Region: MFS_1; pfam07690
696281004056	putative substrate translocation pore; other site
696281004057	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
696281004058	EamA-like transporter family; Region: EamA; pfam00892
696281004059	EamA-like transporter family; Region: EamA; pfam00892
696281004060	Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753
696281004061	Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156
696281004062	tetramer interface [polypeptide binding]; other site
696281004063	heme binding pocket [chemical binding]; other site
696281004064	NADPH binding site [chemical binding]; other site
696281004065	Predicted RNA-binding protein, contains TRAM domain [General function prediction only]; Region: COG3269
696281004066	SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265
696281004067	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
696281004068	S-adenosylmethionine binding site [chemical binding]; other site
696281004069	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
696281004070	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
696281004071	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
696281004072	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
696281004073	DNA-binding interface [nucleotide binding]; DNA binding site
696281004074	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
696281004075	HTH-like domain; Region: HTH_21; pfam13276
696281004076	Integrase core domain; Region: rve; pfam00665
696281004077	Integrase core domain; Region: rve_3; pfam13683
696281004078	CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641
696281004079	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
696281004080	CRISPR-associated protein (Cas_Cas5); Region: Cas_Cas5d; pfam09704
696281004081	CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I-C; cd09651
696281004082	CRISPR/Cas system-associated protein Cas8c; Region: Cas8c_I-C; cl12004
696281004083	CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I-C; cl01465
696281004084	Domain of unknown function DUF83; Region: Cas_Cas4; pfam01930
696281004085	CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-C; cd09721
696281004086	CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725
696281004087	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
696281004088	DNA-binding interface [nucleotide binding]; DNA binding site
696281004089	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
696281004090	HTH-like domain; Region: HTH_21; pfam13276
696281004091	Integrase core domain; Region: rve; pfam00665
696281004092	Integrase core domain; Region: rve_3; pfam13683
696281004093	Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002
696281004094	looped-hinge helix DNA binding domain, AbrB family; Region: lp_hng_hel_AbrB; TIGR01439
696281004095	glucans biosynthesis protein; Provisional; Region: opgC; PRK03854
696281004096	Acyltransferase family; Region: Acyl_transf_3; pfam01757
696281004097	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
696281004098	Ligand Binding Site [chemical binding]; other site
696281004099	Transposase IS200 like; Region: Y1_Tnp; pfam01797
696281004100	Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028
696281004101	classical (c) SDRs; Region: SDR_c; cd05233
696281004102	NAD(P) binding site [chemical binding]; other site
696281004103	active site
696281004104	AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719
696281004105	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
696281004106	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
696281004107	Transposase IS200 like; Region: Y1_Tnp; cl00848
696281004108	tyrosyl-tRNA synthetase; Validated; Region: PRK05912
696281004109	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
696281004110	active site
696281004111	HIGH motif; other site
696281004112	dimer interface [polypeptide binding]; other site
696281004113	KMSKS motif; other site
696281004114	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
696281004115	RNA binding surface [nucleotide binding]; other site
696281004116	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
696281004117	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
696281004118	Choloylglycine hydrolase (CGH)_like. This family of choloylglycine hydrolase-like proteins includes conjugated bile acid hydrolase (CBAH), penicillin V acylase (PVA), acid ceramidase (AC), and N-acylethanolamine-hydrolyzing acid amidase (NAAA) which...; Region: Ntn_CGH_like; cd01935
696281004119	active site
696281004120	Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase; Region: AAT; pfam03417
696281004121	Methyltransferase domain; Region: Methyltransf_23; pfam13489
696281004122	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
696281004123	S-adenosylmethionine binding site [chemical binding]; other site
696281004124	Methyltransferase domain; Region: Methyltransf_31; pfam13847
696281004125	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
696281004126	S-adenosylmethionine binding site [chemical binding]; other site
696281004127	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
696281004128	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
696281004129	active site
696281004130	phosphorylation site [posttranslational modification]
696281004131	intermolecular recognition site; other site
696281004132	dimerization interface [polypeptide binding]; other site
696281004133	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
696281004134	DNA binding site [nucleotide binding]
696281004135	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
696281004136	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
696281004137	dimerization interface [polypeptide binding]; other site
696281004138	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
696281004139	dimer interface [polypeptide binding]; other site
696281004140	phosphorylation site [posttranslational modification]
696281004141	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
696281004142	ATP binding site [chemical binding]; other site
696281004143	Mg2+ binding site [ion binding]; other site
696281004144	G-X-G motif; other site
696281004145	NnaC (CMP-NeuNAc synthetase) _like subfamily of SGNH_hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: NnaC_like; cd01841
696281004146	active site
696281004147	catalytic triad [active]
696281004148	oxyanion hole [active]
696281004149	Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696
696281004150	DHHW protein; Region: DHHW; pfam14286
696281004151	Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106
696281004152	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
696281004153	DNA binding residues [nucleotide binding]
696281004154	dimer interface [polypeptide binding]; other site
696281004155	TipAS antibiotic-recognition domain; Region: TipAS; pfam07739
696281004156	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
696281004157	DNA-binding interface [nucleotide binding]; DNA binding site
696281004158	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
696281004159	HTH-like domain; Region: HTH_21; pfam13276
696281004160	Integrase core domain; Region: rve; pfam00665
696281004161	Integrase core domain; Region: rve_3; pfam13683
696281004162	Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229
696281004163	Uncharacterized conserved protein [Function unknown]; Region: COG0432
696281004164	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
696281004165	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
696281004166	non-specific DNA binding site [nucleotide binding]; other site
696281004167	salt bridge; other site
696281004168	sequence-specific DNA binding site [nucleotide binding]; other site
696281004169	Cupin domain; Region: Cupin_2; pfam07883
696281004170	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
696281004171	Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365
696281004172	acyl-activating enzyme (AAE) consensus motif; other site
696281004173	AMP binding site [chemical binding]; other site
696281004174	active site
696281004175	CoA binding site [chemical binding]; other site
696281004176	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
696281004177	yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840
696281004178	catalytic triad [active]
696281004179	catalytic triad [active]
696281004180	oxyanion hole [active]
696281004181	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
696281004182	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
696281004183	active site
696281004184	phosphorylation site [posttranslational modification]
696281004185	intermolecular recognition site; other site
696281004186	dimerization interface [polypeptide binding]; other site
696281004187	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
696281004188	DNA binding site [nucleotide binding]
696281004189	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
696281004190	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
696281004191	dimerization interface [polypeptide binding]; other site
696281004192	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
696281004193	dimer interface [polypeptide binding]; other site
696281004194	phosphorylation site [posttranslational modification]
696281004195	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
696281004196	ATP binding site [chemical binding]; other site
696281004197	Mg2+ binding site [ion binding]; other site
696281004198	G-X-G motif; other site
696281004199	Predicted transcriptional regulators [Transcription]; Region: COG1695
696281004200	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
696281004201	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
696281004202	Methyltransferase domain; Region: Methyltransf_23; pfam13489
696281004203	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
696281004204	S-adenosylmethionine binding site [chemical binding]; other site
696281004205	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
696281004206	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
696281004207	efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998
696281004208	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
696281004209	HlyD family secretion protein; Region: HlyD_3; pfam13437
696281004210	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
696281004211	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
696281004212	putative substrate translocation pore; other site
696281004213	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
696281004214	Ligand Binding Site [chemical binding]; other site
696281004215	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
696281004216	Domain of unknown function (DUF4180); Region: DUF4180; pfam13788
696281004217	zinc-ribbon domain; Region: zf-ribbon_3; cl11198
696281004218	Double zinc ribbon; Region: DZR; pfam12773
696281004219	Catalytic domain of Protein Kinases; Region: PKc; cd00180
696281004220	active site
696281004221	ATP binding site [chemical binding]; other site
696281004222	substrate binding site [chemical binding]; other site
696281004223	activation loop (A-loop); other site
696281004224	Transcriptional regulators [Transcription]; Region: PurR; COG1609
696281004225	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
696281004226	DNA binding site [nucleotide binding]
696281004227	domain linker motif; other site
696281004228	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
696281004229	dimerization interface [polypeptide binding]; other site
696281004230	ligand binding site [chemical binding]; other site
696281004231	D-ribose pyranase; Provisional; Region: PRK11797
696281004232	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
696281004233	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
696281004234	Walker A/P-loop; other site
696281004235	ATP binding site [chemical binding]; other site
696281004236	Q-loop/lid; other site
696281004237	ABC transporter signature motif; other site
696281004238	Walker B; other site
696281004239	D-loop; other site
696281004240	H-loop/switch region; other site
696281004241	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
696281004242	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
696281004243	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
696281004244	TM-ABC transporter signature motif; other site
696281004245	D-ribose transporter subunit RbsB; Provisional; Region: PRK10653
696281004246	Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323
696281004247	ligand binding site [chemical binding]; other site
696281004248	dimerization interface [polypeptide binding]; other site
696281004249	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
696281004250	Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174
696281004251	substrate binding site [chemical binding]; other site
696281004252	dimer interface [polypeptide binding]; other site
696281004253	ATP binding site [chemical binding]; other site
696281004254	2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959
696281004255	intersubunit interface [polypeptide binding]; other site
696281004256	active site
696281004257	catalytic residue [active]
696281004258	ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866
696281004259	ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730
696281004260	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
696281004261	ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268
696281004262	Walker A/P-loop; other site
696281004263	ATP binding site [chemical binding]; other site
696281004264	Q-loop/lid; other site
696281004265	ABC transporter signature motif; other site
696281004266	Walker B; other site
696281004267	D-loop; other site
696281004268	H-loop/switch region; other site
696281004269	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
696281004270	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
696281004271	active site
696281004272	phosphorylation site [posttranslational modification]
696281004273	intermolecular recognition site; other site
696281004274	dimerization interface [polypeptide binding]; other site
696281004275	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
696281004276	DNA binding site [nucleotide binding]
696281004277	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
696281004278	dimerization interface [polypeptide binding]; other site
696281004279	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
696281004280	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
696281004281	dimer interface [polypeptide binding]; other site
696281004282	phosphorylation site [posttranslational modification]
696281004283	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
696281004284	ATP binding site [chemical binding]; other site
696281004285	Mg2+ binding site [ion binding]; other site
696281004286	G-X-G motif; other site
696281004287	Domain of unknown function (DUF4353); Region: DUF4353; pfam14262
696281004288	Domain of unknown function (DUF4353); Region: DUF4353; pfam14262
696281004289	CotH protein; Region: CotH; pfam08757
696281004290	Polyphosphate(polyP) polymerase domain of yeast vacuolar transport chaperone (VTC) proteins VTC-2, -3 and- 4, and similar proteins; Region: PolyPPase_VTC_like; cd07750
696281004291	putative metal binding residues [ion binding]; other site
696281004292	signature motif; other site
696281004293	dimer interface [polypeptide binding]; other site
696281004294	active site
696281004295	polyP binding site; other site
696281004296	substrate binding site [chemical binding]; other site
696281004297	acceptor-phosphate pocket; other site
696281004298	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
696281004299	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
696281004300	active site
696281004301	phosphorylation site [posttranslational modification]
696281004302	intermolecular recognition site; other site
696281004303	dimerization interface [polypeptide binding]; other site
696281004304	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
696281004305	DNA binding site [nucleotide binding]
696281004306	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
696281004307	dimer interface [polypeptide binding]; other site
696281004308	phosphorylation site [posttranslational modification]
696281004309	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
696281004310	ATP binding site [chemical binding]; other site
696281004311	Mg2+ binding site [ion binding]; other site
696281004312	G-X-G motif; other site
696281004313	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
696281004314	active site
696281004315	DNA binding site [nucleotide binding]
696281004316	Int/Topo IB signature motif; other site
696281004317	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
696281004318	Zn2+ binding site [ion binding]; other site
696281004319	Mg2+ binding site [ion binding]; other site
696281004320	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
696281004321	MarR family; Region: MarR; pfam01047
696281004322	FOG: CBS domain [General function prediction only]; Region: COG0517
696281004323	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
696281004324	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
696281004325	Predicted oxidoreductases of the aldo/keto reductase family [General function prediction only]; Region: COG1453
696281004326	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
696281004327	active site
696281004328	catalytic tetrad [active]
696281004329	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
696281004330	hypothetical protein; Provisional; Region: PRK04194
696281004331	Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954
696281004332	A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; cl17448
696281004333	NCAIR mutase (PurE)-related proteins [General function prediction only]; Region: COG1691
696281004334	AIR carboxylase; Region: AIRC; smart01001
696281004335	Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589
696281004336	Transcriptional regulators [Transcription]; Region: MarR; COG1846
696281004337	MarR family; Region: MarR_2; pfam12802
696281004338	MarR family; Region: MarR_2; cl17246
696281004339	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
696281004340	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
696281004341	Coenzyme A binding pocket [chemical binding]; other site
696281004342	tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282
696281004343	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
696281004344	active site
696281004345	HIGH motif; other site
696281004346	dimer interface [polypeptide binding]; other site
696281004347	KMSKS motif; other site
696281004348	Predicted flavin-nucleotide-binding protein [General function prediction only]; Region: COG3467
696281004349	small acid-soluble spore protein Tlp; Provisional; Region: PRK03830
696281004350	Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315
696281004351	Pirin-related protein [General function prediction only]; Region: COG1741
696281004352	Pirin; Region: Pirin; pfam02678
696281004353	Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726
696281004354	mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997
696281004355	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day.  Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803
696281004356	active site
696281004357	FMN binding site [chemical binding]; other site
696281004358	substrate binding site [chemical binding]; other site
696281004359	putative catalytic residue [active]
696281004360	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
696281004361	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
696281004362	Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655
696281004363	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
696281004364	Predicted transcriptional regulators [Transcription]; Region: COG1733
696281004365	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
696281004366	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
696281004367	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
696281004368	A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066
696281004369	active site
696281004370	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
696281004371	DNA binding residues [nucleotide binding]
696281004372	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
696281004373	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
696281004374	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
696281004375	MarR family; Region: MarR; pfam01047
696281004376	MYM-type Zinc finger with FCS sequence motif; Region: zf-FCS; pfam06467
696281004377	mttA/Hcf106 family; Region: MttA_Hcf106; cl00788
696281004378	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
696281004379	DNA-binding interface [nucleotide binding]; DNA binding site
696281004380	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
696281004381	HTH-like domain; Region: HTH_21; pfam13276
696281004382	Integrase core domain; Region: rve; pfam00665
696281004383	Integrase core domain; Region: rve_3; pfam13683
696281004384	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
696281004385	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
696281004386	active site
696281004387	phosphorylation site [posttranslational modification]
696281004388	intermolecular recognition site; other site
696281004389	dimerization interface [polypeptide binding]; other site
696281004390	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
696281004391	DNA binding site [nucleotide binding]
696281004392	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
696281004393	dimerization interface [polypeptide binding]; other site
696281004394	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
696281004395	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
696281004396	dimer interface [polypeptide binding]; other site
696281004397	phosphorylation site [posttranslational modification]
696281004398	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
696281004399	ATP binding site [chemical binding]; other site
696281004400	Mg2+ binding site [ion binding]; other site
696281004401	G-X-G motif; other site
696281004402	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
696281004403	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
696281004404	active site
696281004405	phosphorylation site [posttranslational modification]
696281004406	intermolecular recognition site; other site
696281004407	dimerization interface [polypeptide binding]; other site
696281004408	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
696281004409	DNA binding site [nucleotide binding]
696281004410	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
696281004411	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
696281004412	dimerization interface [polypeptide binding]; other site
696281004413	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
696281004414	dimer interface [polypeptide binding]; other site
696281004415	phosphorylation site [posttranslational modification]
696281004416	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
696281004417	ATP binding site [chemical binding]; other site
696281004418	Mg2+ binding site [ion binding]; other site
696281004419	G-X-G motif; other site
696281004420	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
696281004421	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
696281004422	Walker A/P-loop; other site
696281004423	ATP binding site [chemical binding]; other site
696281004424	Q-loop/lid; other site
696281004425	ABC transporter signature motif; other site
696281004426	Walker B; other site
696281004427	D-loop; other site
696281004428	H-loop/switch region; other site
696281004429	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
696281004430	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
696281004431	E3 interaction surface; other site
696281004432	lipoyl attachment site [posttranslational modification]; other site
696281004433	HlyD family secretion protein; Region: HlyD_3; pfam13437
696281004434	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
696281004435	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
696281004436	FtsX-like permease family; Region: FtsX; pfam02687
696281004437	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
696281004438	Uncharacterized metal-binding protein [General function prediction only]; Region: COG3894
696281004439	catalytic loop [active]
696281004440	iron binding site [ion binding]; other site
696281004441	The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464
696281004442	methyltransferase cognate corrinoid proteins, Methanosarcina family; Region: pyl_corrinoid; TIGR02370
696281004443	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
696281004444	B12 binding site [chemical binding]; other site
696281004445	methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252
696281004446	The URO-D _like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases. Uroporphyrinogen decarboxylase (URO-D) decarboxylates the four...; Region: URO-D_like; cd03465
696281004447	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
696281004448	GAF domain; Region: GAF; cl17456
696281004449	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
696281004450	ATP binding site [chemical binding]; other site
696281004451	Mg2+ binding site [ion binding]; other site
696281004452	G-X-G motif; other site
696281004453	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
696281004454	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
696281004455	active site
696281004456	phosphorylation site [posttranslational modification]
696281004457	intermolecular recognition site; other site
696281004458	dimerization interface [polypeptide binding]; other site
696281004459	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
696281004460	Walker A motif; other site
696281004461	ATP binding site [chemical binding]; other site
696281004462	Walker B motif; other site
696281004463	arginine finger; other site
696281004464	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
696281004465	Cytochrome c; Region: Cytochrom_C; cl11414
696281004466	Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723
696281004467	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
696281004468	iron-sulfur cluster [ion binding]; other site
696281004469	[2Fe-2S] cluster binding site [ion binding]; other site
696281004470	Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290
696281004471	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859
696281004472	intrachain domain interface; other site
696281004473	interchain domain interface [polypeptide binding]; other site
696281004474	heme bH binding site [chemical binding]; other site
696281004475	Qi binding site; other site
696281004476	heme bL binding site [chemical binding]; other site
696281004477	Qo binding site; other site
696281004478	Cytochrome b(C-terminus)/b6/petD:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cl00193
696281004479	nitrous-oxide reductase, Sec-dependent; Region: nitrous_NosZ_Gp; TIGR04246
696281004480	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
696281004481	nitrous oxide reductase family maturation protein NosD; Region: NosD_copper_fam; TIGR04247
696281004482	parallel beta-helix repeat (two copies); Region: para_beta_helix; TIGR03804
696281004483	parallel beta-helix repeat (two copies); Region: para_beta_helix; TIGR03804
696281004484	parallel beta-helix repeat (two copies); Region: para_beta_helix; TIGR03804
696281004485	NosL; Region: NosL; cl01769
696281004486	ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866
696281004487	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
696281004488	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
696281004489	Walker A/P-loop; other site
696281004490	ATP binding site [chemical binding]; other site
696281004491	Q-loop/lid; other site
696281004492	ABC transporter signature motif; other site
696281004493	Walker B; other site
696281004494	D-loop; other site
696281004495	H-loop/switch region; other site
696281004496	ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125
696281004497	ResB-like family; Region: ResB; pfam05140
696281004498	cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144
696281004499	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
696281004500	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
696281004501	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
696281004502	ferric uptake regulator; Provisional; Region: fur; PRK09462
696281004503	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
696281004504	metal binding site 2 [ion binding]; metal-binding site
696281004505	putative DNA binding helix; other site
696281004506	metal binding site 1 [ion binding]; metal-binding site
696281004507	dimer interface [polypeptide binding]; other site
696281004508	structural Zn2+ binding site [ion binding]; other site
696281004509	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
696281004510	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
696281004511	Coenzyme A binding pocket [chemical binding]; other site
696281004512	YoaP-like; Region: YoaP; pfam14268
696281004513	Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036
696281004514	ArsC family; Region: ArsC; pfam03960
696281004515	putative ArsC-like catalytic residues; other site
696281004516	putative TRX-like catalytic residues [active]
696281004517	Rubrerythrin [Energy production and conversion]; Region: COG1592
696281004518	Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041
696281004519	binuclear metal center [ion binding]; other site
696281004520	Rubredoxin, Small Modular nonheme iron binding domain containing a [Fe(SCys)4] center, present in rubrerythrin and nigerythrin and detected either N- or C-terminal to such proteins as flavin reductase, NAD(P)H-nitrite reductase, and...; Region: rubredoxin_SM; cd00729
696281004521	iron binding site [ion binding]; other site
696281004522	GTP-binding protein YchF; Reviewed; Region: PRK09601
696281004523	YchF GTPase; Region: YchF; cd01900
696281004524	G1 box; other site
696281004525	GTP/Mg2+ binding site [chemical binding]; other site
696281004526	Switch I region; other site
696281004527	G2 box; other site
696281004528	Switch II region; other site
696281004529	G3 box; other site
696281004530	G4 box; other site
696281004531	G5 box; other site
696281004532	TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
696281004533	flavoprotein, HI0933 family; Region: TIGR00275
696281004534	Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965
696281004535	Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105
696281004536	Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574
696281004537	Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH).  DHPS, a...; Region: Pterin_binding; cl00219
696281004538	substrate binding pocket [chemical binding]; other site
696281004539	dimer interface [polypeptide binding]; other site
696281004540	inhibitor binding site; inhibition site
696281004541	B12 binding domain of corrinoid proteins. A family of small methanogenic corrinoid proteins that bind methyl-Co(III) 5-hydroxybenzimidazolylcobamide as a cofactor. They play a role on the methanogenesis from trimethylamine, dimethylamine or...; Region: corrinoid_protein_B12-BD; cd02070
696281004542	methyltransferase cognate corrinoid proteins, Methanosarcina family; Region: pyl_corrinoid; TIGR02370
696281004543	B12 binding site [chemical binding]; other site
696281004544	cobalt ligand [ion binding]; other site
696281004545	Uncharacterized metal-binding protein [General function prediction only]; Region: COG3894
696281004546	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
696281004547	Ferredoxin [Energy production and conversion]; Region: COG1146
696281004548	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
696281004549	Ferredoxin [Energy production and conversion]; Region: Fer; COG1141
696281004550	4Fe-4S binding domain; Region: Fer4; cl02805
696281004551	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
696281004552	This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808
696281004553	putative ADP-binding pocket [chemical binding]; other site
696281004554	Phosphopentomutase [Carbohydrate transport and metabolism]; Region: DeoB; cl17415
696281004555	S-adenosylmethionine decarboxylase proenzyme; Provisional; Region: PRK03124
696281004556	Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210
696281004557	substrate binding pocket [chemical binding]; other site
696281004558	Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226
696281004559	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
696281004560	S-adenosylmethionine binding site [chemical binding]; other site
696281004561	menaquinone biosynthesis decarboxylase, SCO4490 family; Region: mena_SCO4490; TIGR03701
696281004562	4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337
696281004563	UbiA prenyltransferase family; Region: UbiA; pfam01040
696281004564	putative menaquinone biosynthesis protein, SCO4494 family; Region: mena_SCO4494; TIGR03700
696281004565	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
696281004566	FeS/SAM binding site; other site
696281004567	Menaquinone biosynthesis; Region: VitK2_biosynth; pfam02621
696281004568	menaquinone biosynthesis protein, SCO4550 family; Region: mena_SCO4550; TIGR03699
696281004569	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
696281004570	FeS/SAM binding site; other site
696281004571	Rubrerythrin [Energy production and conversion]; Region: COG1592
696281004572	Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041
696281004573	binuclear metal center [ion binding]; other site
696281004574	Rubredoxin, Small Modular nonheme iron binding domain containing a [Fe(SCys)4] center, present in rubrerythrin and nigerythrin and detected either N- or C-terminal to such proteins as flavin reductase, NAD(P)H-nitrite reductase, and...; Region: rubredoxin_SM; cd00729
696281004575	iron binding site [ion binding]; other site
696281004576	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537
696281004577	FAD binding site [chemical binding]; other site
696281004578	Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_7; cd07585
696281004579	Predicted amidohydrolase [General function prediction only]; Region: COG0388
696281004580	putative active site [active]
696281004581	catalytic triad [active]
696281004582	putative dimer interface [polypeptide binding]; other site
696281004583	L-lactate permease; Region: Lactate_perm; cl00701
696281004584	L-lactate permease [Energy production and conversion]; Region: LldP; COG1620
696281004585	L-lactate permease; Region: Lactate_perm; cl00701
696281004586	L-lactate permease [Energy production and conversion]; Region: LldP; COG1620
696281004587	Transcriptional regulators [Transcription]; Region: FadR; COG2186
696281004588	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
696281004589	DNA-binding site [nucleotide binding]; DNA binding site
696281004590	FCD domain; Region: FCD; pfam07729
696281004591	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
696281004592	DNA-binding interface [nucleotide binding]; DNA binding site
696281004593	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
696281004594	HTH-like domain; Region: HTH_21; pfam13276
696281004595	Integrase core domain; Region: rve; pfam00665
696281004596	Integrase core domain; Region: rve_3; pfam13683
696281004597	Transcriptional regulators [Transcription]; Region: FadR; COG2186
696281004598	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
696281004599	DNA-binding site [nucleotide binding]; DNA binding site
696281004600	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
696281004601	selenocysteine synthase; Provisional; Region: PRK04311
696281004602	Selenocysteine synthase N terminal; Region: Se-cys_synth_N; pfam12390
696281004603	Selenocysteine synthase [seryl-tRNASer selenium transferase] [Amino acid transport and metabolism]; Region: SelA; COG1921
696281004604	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
696281004605	catalytic residue [active]
696281004606	selenocysteinyl-tRNA-specific translation factor; Provisional; Region: PRK10512
696281004607	SelB, the dedicated elongation factor for delivery of selenocysteinyl-tRNA to the ribosome; Region: SelB; cd04171
696281004608	G1 box; other site
696281004609	putative GEF interaction site [polypeptide binding]; other site
696281004610	GTP/Mg2+ binding site [chemical binding]; other site
696281004611	Switch I region; other site
696281004612	G2 box; other site
696281004613	G3 box; other site
696281004614	Switch II region; other site
696281004615	G4 box; other site
696281004616	G5 box; other site
696281004617	selB_II: this subfamily represents the domain of elongation factor SelB, homologous to domain II of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several...; Region: selB_II; cd03696
696281004618	This family represents the domain of elongation factor SelB, homologous to domain III of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several elements:...; Region: selB_III; cd04094
696281004619	Elongation factor SelB, winged helix; Region: SelB-wing_2; pfam09106
696281004620	Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107
696281004621	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
696281004622	bis(5'-nucleosyl)-tetraphosphatase PrpE; Provisional; Region: PRK13625
696281004623	active site
696281004624	metal binding site [ion binding]; metal-binding site
696281004625	DNA polymerase II large subunit; Provisional; Region: PRK14714
696281004626	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
696281004627	DNA-binding site [nucleotide binding]; DNA binding site
696281004628	RNA-binding motif; other site
696281004629	Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744
696281004630	Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353
696281004631	putative ligand binding site [chemical binding]; other site
696281004632	ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845
696281004633	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
696281004634	Walker A/P-loop; other site
696281004635	ATP binding site [chemical binding]; other site
696281004636	Q-loop/lid; other site
696281004637	ABC transporter signature motif; other site
696281004638	Walker B; other site
696281004639	D-loop; other site
696281004640	H-loop/switch region; other site
696281004641	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
696281004642	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
696281004643	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
696281004644	TM-ABC transporter signature motif; other site
696281004645	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
696281004646	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
696281004647	TM-ABC transporter signature motif; other site
696281004648	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
696281004649	active site
696281004650	S-layer homology domain; Region: SLH; pfam00395
696281004651	PrcB C-terminal; Region: PrcB_C; pfam14343
696281004652	Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455
696281004653	cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592
696281004654	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
696281004655	Late competence development protein ComFB; Region: ComFB; pfam10719
696281004656	Domain of unknown function (DUF4261); Region: DUF4261; pfam14080
696281004657	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
696281004658	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
696281004659	metal binding site [ion binding]; metal-binding site
696281004660	active site
696281004661	I-site; other site
696281004662	Predicted hydrocarbon binding protein (contains V4R domain) [General function prediction only]; Region: COG1719
696281004663	The V4R (vinyl 4 reductase) domain is a predicted small molecular binding domain, that may bind to hydrocarbons; Region: V4R; smart00989
696281004664	Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049
696281004665	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
696281004666	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
696281004667	dimer interface [polypeptide binding]; other site
696281004668	putative CheW interface [polypeptide binding]; other site
696281004669	Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835
696281004670	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
696281004671	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
696281004672	active site
696281004673	phosphorylation site [posttranslational modification]
696281004674	intermolecular recognition site; other site
696281004675	dimerization interface [polypeptide binding]; other site
696281004676	Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049
696281004677	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
696281004678	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
696281004679	dimer interface [polypeptide binding]; other site
696281004680	putative CheW interface [polypeptide binding]; other site
696281004681	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
696281004682	CESA_like is  the cellulose synthase superfamily; Region: CESA_like; cd06423
696281004683	DXD motif; other site
696281004684	Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632
696281004685	Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247
696281004686	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
696281004687	Coenzyme A binding pocket [chemical binding]; other site
696281004688	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
696281004689	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
696281004690	ATP binding site [chemical binding]; other site
696281004691	Mg2+ binding site [ion binding]; other site
696281004692	G-X-G motif; other site
696281004693	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
696281004694	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
696281004695	active site
696281004696	phosphorylation site [posttranslational modification]
696281004697	intermolecular recognition site; other site
696281004698	LytTr DNA-binding domain; Region: LytTR; pfam04397
696281004699	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
696281004700	Ligand Binding Site [chemical binding]; other site
696281004701	Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer,  utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cd02062
696281004702	FMN binding site [chemical binding]; other site
696281004703	dimer interface [polypeptide binding]; other site
696281004704	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
696281004705	EamA-like transporter family; Region: EamA; pfam00892
696281004706	EamA-like transporter family; Region: EamA; pfam00892
696281004707	Transcriptional regulator [Transcription]; Region: LysR; COG0583
696281004708	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
696281004709	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
696281004710	dimerization interface [polypeptide binding]; other site
696281004711	Flagellin N-methylase; Region: FliB; cl00497
696281004712	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
696281004713	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
696281004714	Coenzyme A binding pocket [chemical binding]; other site
696281004715	Predicted membrane protein [Function unknown]; Region: COG2860
696281004716	UPF0126 domain; Region: UPF0126; pfam03458
696281004717	UPF0126 domain; Region: UPF0126; pfam03458
696281004718	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
696281004719	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
696281004720	active site
696281004721	metal binding site [ion binding]; metal-binding site
696281004722	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
696281004723	Transposase; Region: DEDD_Tnp_IS110; pfam01548
696281004724	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
696281004725	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
696281004726	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
696281004727	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; pfam01118
696281004728	Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272
696281004729	channel protein, hemolysin III family; Region: hlyIII; TIGR01065
696281004730	YkyB-like protein; Region: YkyB; pfam14177
696281004731	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
696281004732	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
696281004733	substrate binding pocket [chemical binding]; other site
696281004734	chain length determination region; other site
696281004735	substrate-Mg2+ binding site; other site
696281004736	catalytic residues [active]
696281004737	aspartate-rich region 1; other site
696281004738	active site lid residues [active]
696281004739	aspartate-rich region 2; other site
696281004740	Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme metabolism]; Region: CysG; COG1648
696281004741	Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241
696281004742	glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045
696281004743	NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213
696281004744	tRNA; other site
696281004745	putative tRNA binding site [nucleotide binding]; other site
696281004746	putative NADP binding site [chemical binding]; other site
696281004747	Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745
696281004748	porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072
696281004749	Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494
696281004750	domain interfaces; other site
696281004751	active site
696281004752	Diphthamide biosynthesis methyltransferase [Translation, ribosomal structure and biogenesis]; Region: DPH5; COG1798
696281004753	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
696281004754	active site
696281004755	SAM binding site [chemical binding]; other site
696281004756	homodimer interface [polypeptide binding]; other site
696281004757	Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587
696281004758	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
696281004759	active site
696281004760	putative heme d1 biosynthesis radical SAM protein NirJ1; Region: rSAM_NirJ1; TIGR04054
696281004761	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
696281004762	FeS/SAM binding site; other site
696281004763	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
696281004764	Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384
696281004765	dimer interface [polypeptide binding]; other site
696281004766	active site
696281004767	Schiff base residues; other site
696281004768	putative heme d1 biosynthesis radical SAM protein NirJ2; Region: rSAM_NirJ2; TIGR04055
696281004769	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
696281004770	FeS/SAM binding site; other site
696281004771	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
696281004772	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
696281004773	AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404
696281004774	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
696281004775	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220
696281004776	glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062
696281004777	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
696281004778	inhibitor-cofactor binding pocket; inhibition site
696281004779	pyridoxal 5'-phosphate binding site [chemical binding]; other site
696281004780	catalytic residue [active]
696281004781	Putative heavy-metal-binding; Region: YbjQ_1; cl00426
696281004782	CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732
696281004783	putative CheA interaction surface; other site
696281004784	putative iron-only hydrogenase system regulator; Region: hyd_TM1266; TIGR03959
696281004785	aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273
696281004786	Aspartase; Region: Aspartase; cd01357
696281004787	active sites [active]
696281004788	tetramer interface [polypeptide binding]; other site
696281004789	[FeFe] hydrogenase H-cluster maturation GTPase HydF; Region: GTP_HydF; TIGR03918
696281004790	E. coli Ras-like protein (Era)-like GTPase; Region: Era_like; cd00880
696281004791	G1 box; other site
696281004792	GTP/Mg2+ binding site [chemical binding]; other site
696281004793	Switch I region; other site
696281004794	G2 box; other site
696281004795	Switch II region; other site
696281004796	G3 box; other site
696281004797	G4 box; other site
696281004798	G5 box; other site
696281004799	biotin synthase; Provisional; Region: PRK07094
696281004800	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
696281004801	FeS/SAM binding site; other site
696281004802	Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876
696281004803	thiamine biosynthesis protein ThiH; Reviewed; Region: thiH; PRK09613
696281004804	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
696281004805	FeS/SAM binding site; other site
696281004806	Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876
696281004807	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
696281004808	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
696281004809	DNA-binding site [nucleotide binding]; DNA binding site
696281004810	TrkA-C domain; Region: TrkA_C; pfam02080
696281004811	Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509
696281004812	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
696281004813	FeS/SAM binding site; other site
696281004814	Lysine-2,3-aminomutase; Region: LAM_C; pfam12544
696281004815	SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195
696281004816	DNA alkylation repair enzyme [DNA replication, recombination, and repair]; Region: COG4335
696281004817	Stress responsive A/B Barrel Domain; Region: Dabb; smart00886
696281004818	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
696281004819	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
696281004820	Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148
696281004821	The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia.  This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cd00316
696281004822	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
696281004823	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
696281004824	Coenzyme A binding pocket [chemical binding]; other site
696281004825	This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267
696281004826	Prenyltransferase-like; Region: Prenyltrans_1; pfam13243
696281004827	Aminoglycoside-2''-adenylyltransferase; Region: Aminoglyc_resit; pfam10706
696281004828	PAS domain; Region: PAS_9; pfam13426
696281004829	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
696281004830	putative active site [active]
696281004831	heme pocket [chemical binding]; other site
696281004832	PAS fold; Region: PAS_4; pfam08448
696281004833	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
696281004834	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
696281004835	putative active site [active]
696281004836	heme pocket [chemical binding]; other site
696281004837	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
696281004838	dimer interface [polypeptide binding]; other site
696281004839	phosphorylation site [posttranslational modification]
696281004840	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
696281004841	ATP binding site [chemical binding]; other site
696281004842	Mg2+ binding site [ion binding]; other site
696281004843	G-X-G motif; other site
696281004844	Response regulator receiver domain; Region: Response_reg; pfam00072
696281004845	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
696281004846	active site
696281004847	phosphorylation site [posttranslational modification]
696281004848	intermolecular recognition site; other site
696281004849	dimerization interface [polypeptide binding]; other site
696281004850	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
696281004851	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
696281004852	active site
696281004853	phosphorylation site [posttranslational modification]
696281004854	intermolecular recognition site; other site
696281004855	Response regulator receiver domain; Region: Response_reg; pfam00072
696281004856	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
696281004857	active site
696281004858	phosphorylation site [posttranslational modification]
696281004859	intermolecular recognition site; other site
696281004860	dimerization interface [polypeptide binding]; other site
696281004861	Hpt domain; Region: Hpt; pfam01627
696281004862	putative binding surface; other site
696281004863	active site
696281004864	branched-chain amino acid aminotransferase; Provisional; Region: PRK13357
696281004865	BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids  leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557
696281004866	homodimer interface [polypeptide binding]; other site
696281004867	substrate-cofactor binding pocket; other site
696281004868	catalytic residue [active]
696281004869	Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519
696281004870	Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519
696281004871	Dienelactone hydrolase family; Region: DLH; pfam01738
696281004872	benzoate transport; Region: 2A0115; TIGR00895
696281004873	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
696281004874	putative substrate translocation pore; other site
696281004875	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
696281004876	Transcriptional regulator [Transcription]; Region: LysR; COG0583
696281004877	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
696281004878	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
696281004879	dimerization interface [polypeptide binding]; other site
696281004880	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
696281004881	lipoyl attachment site [posttranslational modification]; other site
696281004882	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
696281004883	anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG2; TIGR02495
696281004884	Domain of unknown function (DUF1877); Region: DUF1877; pfam08974
696281004885	Arylsulfotransferase (ASST); Region: Arylsulfotrans; pfam05935
696281004886	dihydrolipoamide dehydrogenase; Region: lipoamide_DH; TIGR01350
696281004887	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
696281004888	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
696281004889	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
696281004890	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
696281004891	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
696281004892	ligand binding site [chemical binding]; other site
696281004893	flexible hinge region; other site
696281004894	Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545
696281004895	putative switch regulator; other site
696281004896	non-specific DNA interactions [nucleotide binding]; other site
696281004897	DNA binding site [nucleotide binding]
696281004898	sequence specific DNA binding site [nucleotide binding]; other site
696281004899	putative cAMP binding site [chemical binding]; other site
696281004900	Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239
696281004901	Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239
696281004902	Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663
696281004903	Sulfatase; Region: Sulfatase; cl17466
696281004904	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
696281004905	Nitrite and sulphite reductase 4Fe-4S domain; Region: NIR_SIR; pfam01077
696281004906	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
696281004907	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
696281004908	active site
696281004909	phosphorylation site [posttranslational modification]
696281004910	intermolecular recognition site; other site
696281004911	dimerization interface [polypeptide binding]; other site
696281004912	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
696281004913	DNA binding residues [nucleotide binding]
696281004914	dimerization interface [polypeptide binding]; other site
696281004915	Sensor protein DegS; Region: DegS; pfam05384
696281004916	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
696281004917	Histidine kinase; Region: HisKA_3; pfam07730
696281004918	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
696281004919	ATP binding site [chemical binding]; other site
696281004920	Mg2+ binding site [ion binding]; other site
696281004921	G-X-G motif; other site
696281004922	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
696281004923	dimerization interface [polypeptide binding]; other site
696281004924	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
696281004925	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
696281004926	dimer interface [polypeptide binding]; other site
696281004927	putative CheW interface [polypeptide binding]; other site
696281004928	PBP superfamily domain; Region: PBP_like_2; cl17296
696281004929	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
696281004930	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573
696281004931	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
696281004932	dimer interface [polypeptide binding]; other site
696281004933	conserved gate region; other site
696281004934	putative PBP binding loops; other site
696281004935	ABC-ATPase subunit interface; other site
696281004936	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581
696281004937	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
696281004938	dimer interface [polypeptide binding]; other site
696281004939	conserved gate region; other site
696281004940	putative PBP binding loops; other site
696281004941	ABC-ATPase subunit interface; other site
696281004942	Replication initiation and membrane attachment; Region: DnaB_2; pfam07261
696281004943	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
696281004944	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
696281004945	Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486
696281004946	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
696281004947	Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605
696281004948	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
696281004949	Transglycosylase; Region: Transgly; pfam00912
696281004950	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
696281004951	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
696281004952	Protein of unknown function (DUF2892); Region: DUF2892; pfam11127
696281004953	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
696281004954	H+ Antiporter protein; Region: 2A0121; TIGR00900
696281004955	putative substrate translocation pore; other site
696281004956	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_17; cd04676
696281004957	nudix motif; other site
696281004958	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
696281004959	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
696281004960	Transcriptional regulators [Transcription]; Region: FadR; COG2186
696281004961	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
696281004962	DNA-binding site [nucleotide binding]; DNA binding site
696281004963	FCD domain; Region: FCD; pfam07729
696281004964	Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173
696281004965	ligand binding site [chemical binding]; other site
696281004966	NAD binding site [chemical binding]; other site
696281004967	dimerization interface [polypeptide binding]; other site
696281004968	catalytic site [active]
696281004969	Malate/L-lactate dehydrogenases [Energy production and conversion]; Region: COG2055
696281004970	Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613
696281004971	D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295
696281004972	Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331
696281004973	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3333
696281004974	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181
696281004975	integral membrane protein, YjbE family; Region: R_switched_YjbE; TIGR03717
696281004976	Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613
696281004977	D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295
696281004978	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181
696281004979	ABC-type amino acid transport/signal transduction systems, periplasmic component/domain [Amino acid transport and metabolism / Signal transduction mechanisms]; Region: HisJ; COG0834
696281004980	propanediol utilization phosphotransacylase; Provisional; Region: PRK15070
696281004981	Propanediol utilisation protein PduL; Region: PduL; pfam06130
696281004982	Propanediol utilisation protein PduL; Region: PduL; pfam06130
696281004983	acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180
696281004984	propionate/acetate kinase; Provisional; Region: PRK12379
696281004985	riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326
696281004986	Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284
696281004987	catalytic motif [active]
696281004988	Zn binding site [ion binding]; other site
696281004989	RibD C-terminal domain; Region: RibD_C; cl17279
696281004990	Lumazine binding domain; Region: Lum_binding; pfam00677
696281004991	riboflavin synthase subunit alpha; Provisional; Region: PRK09289
696281004992	Lumazine binding domain; Region: Lum_binding; pfam00677
696281004993	bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311
696281004994	3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926
696281004995	GTP cyclohydrolase II (RibA).  GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641
696281004996	dimerization interface [polypeptide binding]; other site
696281004997	active site
696281004998	lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209
696281004999	homopentamer interface [polypeptide binding]; other site
696281005000	active site
696281005001	50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359
696281005002	ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917
696281005003	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
696281005004	generic binding surface II; other site
696281005005	ssDNA binding site; other site
696281005006	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
696281005007	ATP binding site [chemical binding]; other site
696281005008	putative Mg++ binding site [ion binding]; other site
696281005009	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
696281005010	nucleotide binding region [chemical binding]; other site
696281005011	ATP-binding site [chemical binding]; other site
696281005012	Formylmethanofuran dehydrogenase subunit E [Energy production and conversion]; Region: COG2191
696281005013	FmdE, Molybdenum formylmethanofuran dehydrogenase operon; Region: FmdE; pfam02663
696281005014	Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; pfam01258
696281005015	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
696281005016	Metal binding protein HemV-2.  These proteins are predicted to function as initial receptors in ABC transport of metal ions.  They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and ligand binding...; Region: HemV-2; cd01147
696281005017	putative metal binding site [ion binding]; other site
696281005018	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
696281005019	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
696281005020	ABC-ATPase subunit  interface; other site
696281005021	dimer interface [polypeptide binding]; other site
696281005022	putative PBP binding regions; other site
696281005023	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
696281005024	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
696281005025	Walker A/P-loop; other site
696281005026	ATP binding site [chemical binding]; other site
696281005027	Q-loop/lid; other site
696281005028	ABC transporter signature motif; other site
696281005029	Walker B; other site
696281005030	D-loop; other site
696281005031	H-loop/switch region; other site
696281005032	germination protease; Provisional; Region: PRK12362
696281005033	Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602
696281005034	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
696281005035	S-adenosylmethionine binding site [chemical binding]; other site
696281005036	phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168
696281005037	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
696281005038	active site
696281005039	(T/H)XGH motif; other site
696281005040	Hsp70 protein; Region: HSP70; pfam00012
696281005041	BioD-like N-terminal domain of phosphotransacetylase [General function prediction only]; Region: Pta; COG0857
696281005042	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
696281005043	DRTGG domain; Region: DRTGG; pfam07085
696281005044	acetyl coenzyme A synthetase (ADP forming), alpha domain; Region: AcCoA-syn-alpha; TIGR02717
696281005045	CoA binding domain; Region: CoA_binding_2; pfam13380
696281005046	Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607
696281005047	ATP-grasp domain; Region: ATP-grasp_5; pfam13549
696281005048	Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042
696281005049	sporulation integral membrane protein YlbJ; Region: spore_ylbJ; TIGR02871
696281005050	Nucleoside recognition; Region: Gate; pfam07670
696281005051	Uncharacterized ACR, COG1399; Region: DUF177; pfam02620
696281005052	50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286
696281005053	fatty acid biosynthesis transcriptional regulator; Provisional; Region: PRK04424
696281005054	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531
696281005055	HGG motif-containing thioesterase, possibly involved in aromatic compounds catabolism [Secondary metabolites biosynthesis,    transport, and catabolism]; Region: PaaI; COG2050
696281005056	active site 2 [active]
696281005057	putative phosphate acyltransferase; Provisional; Region: PRK05331
696281005058	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
696281005059	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
696281005060	dimer interface [polypeptide binding]; other site
696281005061	active site
696281005062	CoA binding pocket [chemical binding]; other site
696281005063	putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151
696281005064	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
696281005065	FMN binding site [chemical binding]; other site
696281005066	substrate binding site [chemical binding]; other site
696281005067	putative catalytic residue [active]
696281005068	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
696281005069	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
696281005070	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
696281005071	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
696281005072	NAD(P) binding site [chemical binding]; other site
696281005073	active site
696281005074	acyl carrier protein; Provisional; Region: acpP; PRK00982
696281005075	beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150
696281005076	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
696281005077	dimer interface [polypeptide binding]; other site
696281005078	active site
696281005079	ribonuclease III; Reviewed; Region: rnc; PRK00102
696281005080	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
696281005081	dimerization interface [polypeptide binding]; other site
696281005082	active site
696281005083	metal binding site [ion binding]; metal-binding site
696281005084	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
696281005085	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
696281005086	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
696281005087	Walker A/P-loop; other site
696281005088	ATP binding site [chemical binding]; other site
696281005089	SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968
696281005090	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
696281005091	ABC transporter signature motif; other site
696281005092	Walker B; other site
696281005093	D-loop; other site
696281005094	H-loop/switch region; other site
696281005095	signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416
696281005096	SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881
696281005097	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
696281005098	P loop; other site
696281005099	GTP binding site [chemical binding]; other site
696281005100	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
696281005101	Domain of unknown function DUF21; Region: DUF21; pfam01595
696281005102	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
696281005103	Transporter associated domain; Region: CorC_HlyC; smart01091
696281005104	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
696281005105	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
696281005106	active site
696281005107	metal binding site [ion binding]; metal-binding site
696281005108	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
696281005109	Uncharacterized protein conserved in bacteria (DUF2313); Region: DUF2313; cl01542
696281005110	Uncharacterized homolog of phage Mu protein gp47 [Function unknown]; Region: XkdT; COG3299
696281005111	Gene 25-like lysozyme; Region: GPW_gp25; pfam04965
696281005112	Phage late control gene D protein (GPD); Region: Phage_GPD; cl15796
696281005113	Uncharacterized protein containing LysM domain [Function unknown]; Region: XkdP; COG1652
696281005114	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
696281005115	phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760
696281005116	Protein of unknown function (DUF2001); Region: DUF2001; pfam09393
696281005117	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
696281005118	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
696281005119	Phage tail sheath protein; Region: Phage_sheath_1; pfam04984
696281005120	Phage virion morphogenesis family; Region: Phage_tail_S; cl02089
696281005121	Phage major capsid protein E; Region: Phage_cap_E; pfam03864
696281005122	Mu-like prophage I protein; Region: Mu-like_Pro; pfam10123
696281005123	Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072
696281005124	Protein of unknown function (DUF935); Region: DUF935; pfam06074
696281005125	Phage terminase large subunit (GpA); Region: Terminase_GpA; pfam05876
696281005126	Protein of unknown function (DUF3486); Region: DUF3486; pfam11985
696281005127	Mor transcription activator family; Region: Mor; cl02360
696281005128	Protein of unknown function (DUF1018); Region: DUF1018; cl01815
696281005129	Bacteriophage Mu Gam like protein; Region: Phage_Mu_Gam; cl01825
696281005130	hypothetical protein; Validated; Region: PRK08116
696281005131	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
696281005132	Walker A motif; other site
696281005133	ATP binding site [chemical binding]; other site
696281005134	GIYX(10-11)YIG family of class I homing endonucleases C-terminus (GIY-YIG_Cterm). Homing endonucleases promote the mobility of intron or intein by recognizing and cleaving a homologous allele that lacks the sequence. They catalyze a double-strand break...; Region: GIY-YIG_Cterm; cl11508
696281005135	AAA domain; Region: AAA_22; pfam13401
696281005136	AAA domain; Region: AAA_14; pfam13173
696281005137	Winged helix-turn helix; Region: HTH_29; pfam13551
696281005138	Mu DNA binding, I gamma subdomain; Region: HTH_Tnp_Mu_2; pfam09039
696281005139	Integrase core domain; Region: rve; pfam00665
696281005140	Integrase core domain; Region: rve_3; cl15866
696281005141	Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299
696281005142	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
696281005143	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
696281005144	non-specific DNA binding site [nucleotide binding]; other site
696281005145	salt bridge; other site
696281005146	sequence-specific DNA binding site [nucleotide binding]; other site
696281005147	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
696281005148	Catalytic site [active]
696281005149	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
696281005150	Domain of unknown function DUF21; Region: DUF21; pfam01595
696281005151	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
696281005152	Transporter associated domain; Region: CorC_HlyC; smart01091
696281005153	Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg4; cd04779
696281005154	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
696281005155	DNA binding residues [nucleotide binding]
696281005156	putative dimer interface [polypeptide binding]; other site
696281005157	Sporulation control protein [General function prediction only]; Region: Spo0M; COG4326
696281005158	Peptidase family M48; Region: Peptidase_M48; cl12018
696281005159	5'-methylthioadenosine phosphorylase; Validated; Region: PRK08666
696281005160	Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]; Region: COG0182
696281005161	methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720
696281005162	S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476
696281005163	S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401
696281005164	homotetramer interface [polypeptide binding]; other site
696281005165	ligand binding site [chemical binding]; other site
696281005166	catalytic site [active]
696281005167	NAD binding site [chemical binding]; other site
696281005168	Ribulose-5-phosphate 4-epimerase and related epimerases and aldolases [Carbohydrate transport and metabolism]; Region: AraD; COG0235
696281005169	intersubunit interface [polypeptide binding]; other site
696281005170	active site
696281005171	Zn2+ binding site [ion binding]; other site
696281005172	N-ethylammeline chlorohydrolase; Provisional; Region: PRK06038
696281005173	TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298
696281005174	active site
696281005175	putative substrate binding pocket [chemical binding]; other site
696281005176	Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase; Region: PUA; smart00359
696281005177	Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092
696281005178	Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572
696281005179	putative RNA binding site [nucleotide binding]; other site
696281005180	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
696281005181	S-adenosylmethionine binding site [chemical binding]; other site
696281005182	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
696281005183	Divergent AAA domain; Region: AAA_4; pfam04326
696281005184	Ornithine/acetylornithine aminotransferase [Amino acid transport and metabolism]; Region: ArgD; COG4992
696281005185	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
696281005186	inhibitor-cofactor binding pocket; inhibition site
696281005187	pyridoxal 5'-phosphate binding site [chemical binding]; other site
696281005188	catalytic residue [active]
696281005189	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
696281005190	DNA binding residues [nucleotide binding]
696281005191	signal recognition particle protein; Provisional; Region: PRK10867
696281005192	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
696281005193	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
696281005194	P loop; other site
696281005195	GTP binding site [chemical binding]; other site
696281005196	Signal peptide binding domain; Region: SRP_SPB; pfam02978
696281005197	30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040
696281005198	Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837
696281005199	hypothetical protein; Provisional; Region: PRK00468
696281005200	Protein of unknown function (DUF2869); Region: DUF2869; pfam11068
696281005201	16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122
696281005202	RimM N-terminal domain; Region: RimM; pfam01782
696281005203	tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026
696281005204	50S ribosomal protein L19; Provisional; Region: rplS; PRK05338
696281005205	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
696281005206	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
696281005207	Catalytic site [active]
696281005208	GTPase YlqF; Reviewed; Region: rbgA; PRK09563
696281005209	Circularly permuted YlqF GTPase; Region: YlqF; cd01856
696281005210	GTP/Mg2+ binding site [chemical binding]; other site
696281005211	G4 box; other site
696281005212	G5 box; other site
696281005213	G1 box; other site
696281005214	Switch I region; other site
696281005215	G2 box; other site
696281005216	G3 box; other site
696281005217	Switch II region; other site
696281005218	bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
696281005219	RNA/DNA hybrid binding site [nucleotide binding]; other site
696281005220	active site
696281005221	NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535
696281005222	NADH dehydrogenase subunit B; Validated; Region: PRK06411
696281005223	NADH:ubiquinone oxidoreductase 27 kD subunit [Energy production and conversion]; Region: NuoC; COG0852
696281005224	Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; pfam00329
696281005225	NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649
696281005226	NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338
696281005227	NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076
696281005228	Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650
696281005229	NADH-quinone oxidoreductase, chain I; Region: NuoI; TIGR01971
696281005230	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
696281005231	NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638
696281005232	NADH dehydrogenase subunit J; Provisional; Region: PRK06433
696281005233	NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715
696281005234	NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590
696281005235	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662
696281005236	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
696281005237	NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846
696281005238	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
696281005239	NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777
696281005240	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
696281005241	hypothetical protein; Reviewed; Region: PRK12497
696281005242	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
696281005243	RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652
696281005244	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
696281005245	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
696281005246	DNA binding residues [nucleotide binding]
696281005247	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
696281005248	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
696281005249	dimerization interface [polypeptide binding]; other site
696281005250	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
696281005251	dimer interface [polypeptide binding]; other site
696281005252	Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015
696281005253	putative CheW interface [polypeptide binding]; other site
696281005254	Uncharacterized conserved protein [Function unknown]; Region: COG3603
696281005255	Family description; Region: ACT_7; pfam13840
696281005256	transaminase; Validated; Region: PRK07324
696281005257	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
696281005258	pyridoxal 5'-phosphate binding site [chemical binding]; other site
696281005259	homodimer interface [polypeptide binding]; other site
696281005260	catalytic residue [active]
696281005261	Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606
696281005262	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
696281005263	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
696281005264	Walker A motif; other site
696281005265	ATP binding site [chemical binding]; other site
696281005266	Walker B motif; other site
696281005267	arginine finger; other site
696281005268	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335
696281005269	O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873
696281005270	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
696281005271	homodimer interface [polypeptide binding]; other site
696281005272	substrate-cofactor binding pocket; other site
696281005273	pyridoxal 5'-phosphate binding site [chemical binding]; other site
696281005274	catalytic residue [active]
696281005275	homoserine O-succinyltransferase; Provisional; Region: PRK05368
696281005276	Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131
696281005277	proposed active site lysine [active]
696281005278	conserved cys residue [active]
696281005279	FOG: CBS domain [General function prediction only]; Region: COG0517
696281005280	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the BON (bacterial OsmY and nodulation domain) domain. BON is a putative phospholipid-binding domain found in a family of osmotic shock protection...; Region: CBS_pair_BON_assoc; cd04586
696281005281	Protein of unknown function DUF89; Region: DUF89; cl15397
696281005282	Domain of unknown function (DUF1992); Region: DUF1992; pfam09350
696281005283	Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055
696281005284	Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the...; Region: P_permease; cd01116
696281005285	transmembrane helices; other site
696281005286	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
696281005287	exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025
696281005288	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
696281005289	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
696281005290	Walker A motif; other site
696281005291	ATP binding site [chemical binding]; other site
696281005292	Walker B motif; other site
696281005293	arginine finger; other site
696281005294	Protein of unknown function (DUF456); Region: DUF456; pfam04306
696281005295	UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769
696281005296	Domain of unknown function (DUF1727); Region: DUF1727; pfam08353
696281005297	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750
696281005298	catalytic triad [active]
696281005299	Putative Ser protein kinase [Signal transduction mechanisms]; Region: PrkA; COG2766
696281005300	PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798
696281005301	sporulation protein YhbH; Region: spore_yhbH; TIGR02877
696281005302	SpoVR like protein; Region: SpoVR; pfam04293
696281005303	Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719
696281005304	Ku protein, prokaryotic; Region: Ku_bact; TIGR02772
696281005305	Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789
696281005306	putative DNA binding site [nucleotide binding]; other site
696281005307	putative homodimer interface [polypeptide binding]; other site
696281005308	Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906
696281005309	DNA polymerase LigD, ligase domain; Region: NHEJ_ligase_lig; TIGR02779
696281005310	active site
696281005311	DNA binding site [nucleotide binding]
696281005312	The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971
696281005313	DNA binding site [nucleotide binding]
696281005314	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
696281005315	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
696281005316	active site
696281005317	phosphorylation site [posttranslational modification]
696281005318	intermolecular recognition site; other site
696281005319	dimerization interface [polypeptide binding]; other site
696281005320	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
696281005321	Walker A motif; other site
696281005322	ATP binding site [chemical binding]; other site
696281005323	Walker B motif; other site
696281005324	arginine finger; other site
696281005325	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
696281005326	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
696281005327	dimer interface [polypeptide binding]; other site
696281005328	phosphorylation site [posttranslational modification]
696281005329	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
696281005330	ATP binding site [chemical binding]; other site
696281005331	Mg2+ binding site [ion binding]; other site
696281005332	G-X-G motif; other site
696281005333	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205
696281005334	Helix-turn-helix domain; Region: HTH_36; pfam13730
696281005335	WYL domain; Region: WYL; pfam13280
696281005336	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
696281005337	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
696281005338	Sulfate transporter family; Region: Sulfate_transp; pfam00916
696281005339	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
696281005340	Uncharacterized conserved protein (DUF2294); Region: DUF2294; pfam10057
696281005341	LigD_Pol_like_2: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD, subgroup 2. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required...; Region: LigD_Pol_like_2; cd04865
696281005342	nucleotide binding site [chemical binding]; other site
696281005343	Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758
696281005344	DNA protecting protein DprA; Region: dprA; TIGR00732
696281005345	DNA topoisomerase I; Validated; Region: PRK05582
696281005346	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363
696281005347	active site
696281005348	interdomain interaction site; other site
696281005349	putative metal-binding site [ion binding]; other site
696281005350	nucleotide binding site [chemical binding]; other site
696281005351	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
696281005352	domain I; other site
696281005353	DNA binding groove [nucleotide binding]
696281005354	phosphate binding site [ion binding]; other site
696281005355	domain II; other site
696281005356	domain III; other site
696281005357	nucleotide binding site [chemical binding]; other site
696281005358	catalytic site [active]
696281005359	domain IV; other site
696281005360	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
696281005361	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
696281005362	tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335
696281005363	Glucose inhibited division protein A; Region: GIDA; pfam01134
696281005364	XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798
696281005365	tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224
696281005366	active site
696281005367	Int/Topo IB signature motif; other site
696281005368	Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913
696281005369	active site
696281005370	HslU subunit interaction site [polypeptide binding]; other site
696281005371	ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201
696281005372	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
696281005373	Walker A motif; other site
696281005374	ATP binding site [chemical binding]; other site
696281005375	AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724
696281005376	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
696281005377	transcriptional repressor CodY; Validated; Region: PRK04158
696281005378	CodY GAF-like domain; Region: CodY; pfam06018
696281005379	CodY helix-turn-helix domain; Region: HTH_CodY; pfam08222
696281005380	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
696281005381	rRNA interaction site [nucleotide binding]; other site
696281005382	S8 interaction site; other site
696281005383	putative laminin-1 binding site; other site
696281005384	elongation factor Ts; Reviewed; Region: tsf; PRK12332
696281005385	UBA/TS-N domain; Region: UBA; pfam00627
696281005386	Elongation factor TS; Region: EF_TS; pfam00889
696281005387	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
696281005388	putative nucleotide binding site [chemical binding]; other site
696281005389	uridine monophosphate binding site [chemical binding]; other site
696281005390	homohexameric interface [polypeptide binding]; other site
696281005391	ribosome recycling factor; Reviewed; Region: frr; PRK00083
696281005392	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520
696281005393	hinge region; other site
696281005394	PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and...; Region: PASTA; cl02768
696281005395	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
696281005396	4Fe-4S dicluster domain; Region: Fer4_9; pfam13187
696281005397	Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020
696281005398	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475
696281005399	catalytic residue [active]
696281005400	putative FPP diphosphate  binding site; other site
696281005401	putative FPP binding hydrophobic cleft; other site
696281005402	dimer interface [polypeptide binding]; other site
696281005403	putative IPP diphosphate binding site; other site
696281005404	CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575
696281005405	Cytidylyltransferase family; Region: CTP_transf_1; pfam01148
696281005406	Domain of unknown function DUF20; Region: UPF0118; pfam01594
696281005407	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465
696281005408	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447
696281005409	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670
696281005410	1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436
696281005411	DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288
696281005412	Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750
696281005413	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
696281005414	active site
696281005415	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
696281005416	protein binding site [polypeptide binding]; other site
696281005417	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
696281005418	putative substrate binding region [chemical binding]; other site
696281005419	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366
696281005420	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
696281005421	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
696281005422	prolyl-tRNA synthetase; Provisional; Region: PRK09194
696281005423	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779
696281005424	dimer interface [polypeptide binding]; other site
696281005425	motif 1; other site
696281005426	active site
696281005427	motif 2; other site
696281005428	INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334
696281005429	putative deacylase active site [active]
696281005430	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
696281005431	active site
696281005432	motif 3; other site
696281005433	ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861
696281005434	anticodon binding site; other site
696281005435	diacylglycerol glucosyltransferase; Provisional; Region: PRK13609
696281005436	Monogalactosyldiacylglycerol (MGDG) synthase; Region: MGDG_synth; pfam06925
696281005437	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
696281005438	DNA polymerase III PolC; Validated; Region: polC; PRK00448
696281005439	DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490
696281005440	polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484
696281005441	generic binding surface II; other site
696281005442	generic binding surface I; other site
696281005443	Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102
696281005444	active site
696281005445	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
696281005446	active site
696281005447	catalytic site [active]
696281005448	substrate binding site [chemical binding]; other site
696281005449	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435
696281005450	Putative regulatory protein; Region: CxxC_CXXC_SSSS; smart00834
696281005451	Bacterial Ig-like domain; Region: Big_5; pfam13205
696281005452	Catalytic NodB homology domain of Bacillus subtilis polysaccharide deacetylase PdaA, and its bacterial homologs; Region: CE4_BsPdaA_like; cd10948
696281005453	delta-lactam-biosynthetic de-N-acetylase; Region: spore_pdaA; TIGR02884
696281005454	NodB motif; other site
696281005455	active site
696281005456	catalytic site [active]
696281005457	Cd binding site [ion binding]; other site
696281005458	DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595
696281005459	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
696281005460	Domain of unknown function (DUF4179); Region: DUF4179; pfam13786
696281005461	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
696281005462	DNA-binding interface [nucleotide binding]; DNA binding site
696281005463	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
696281005464	HTH-like domain; Region: HTH_21; pfam13276
696281005465	Integrase core domain; Region: rve; pfam00665
696281005466	Integrase core domain; Region: rve_3; pfam13683
696281005467	Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613
696281005468	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase; Region: PHP_HisPPase; cd07432
696281005469	active site
696281005470	Protein of unknown function (DUF1049); Region: DUF1049; pfam06305
696281005471	ribosome maturation protein RimP; Reviewed; Region: PRK00092
696281005472	Sm and related proteins; Region: Sm_like; cl00259
696281005473	Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734
696281005474	putative oligomer interface [polypeptide binding]; other site
696281005475	putative RNA binding site [nucleotide binding]; other site
696281005476	transcription elongation factor NusA; Provisional; Region: nusA; PRK12327
696281005477	NusA N-terminal domain; Region: NusA_N; pfam08529
696281005478	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
696281005479	RNA binding site [nucleotide binding]; other site
696281005480	homodimer interface [polypeptide binding]; other site
696281005481	NusA-like KH domain; Region: KH_5; pfam13184
696281005482	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
696281005483	G-X-X-G motif; other site
696281005484	Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279
696281005485	putative RNA binding cleft [nucleotide binding]; other site
696281005486	Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600
696281005487	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
696281005488	Prion/Doppel alpha-helical domain; Region: Prion; cl02493
696281005489	translation initiation factor IF-2; Region: IF-2; TIGR00487
696281005490	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
696281005491	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
696281005492	G1 box; other site
696281005493	putative GEF interaction site [polypeptide binding]; other site
696281005494	GTP/Mg2+ binding site [chemical binding]; other site
696281005495	Switch I region; other site
696281005496	G2 box; other site
696281005497	G3 box; other site
696281005498	Switch II region; other site
696281005499	G4 box; other site
696281005500	G5 box; other site
696281005501	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
696281005502	Translation-initiation factor 2; Region: IF-2; pfam11987
696281005503	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
696281005504	ribosome-binding factor A; Validated; Region: rbfA; PRK00521
696281005505	Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618
696281005506	DHH family; Region: DHH; pfam01368
696281005507	DHHA1 domain; Region: DHHA1; pfam02272
696281005508	tRNA pseudouridine synthase B; Provisional; Region: truB; PRK00130
696281005509	Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573
696281005510	RNA binding site [nucleotide binding]; other site
696281005511	active site
696281005512	PUA domain; Region: PUA; pfam01472
696281005513	bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627
696281005514	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
696281005515	active site
696281005516	Riboflavin kinase; Region: Flavokinase; pfam01687
696281005517	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
696281005518	16S/18S rRNA binding site [nucleotide binding]; other site
696281005519	S13e-L30e interaction site [polypeptide binding]; other site
696281005520	25S rRNA binding site [nucleotide binding]; other site
696281005521	polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824
696281005522	Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363
696281005523	RNase E interface [polypeptide binding]; other site
696281005524	trimer interface [polypeptide binding]; other site
696281005525	Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726
696281005526	Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364
696281005527	RNase E interface [polypeptide binding]; other site
696281005528	trimer interface [polypeptide binding]; other site
696281005529	active site
696281005530	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
696281005531	putative nucleic acid binding region [nucleotide binding]; other site
696281005532	G-X-X-G motif; other site
696281005533	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
696281005534	RNA binding site [nucleotide binding]; other site
696281005535	domain interface; other site
696281005536	spore cortex-lytic enzyme; Region: spore_SleB; TIGR02869
696281005537	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
696281005538	Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486
696281005539	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
696281005540	Putative catalytic NodB homology domain of uncharacterized protein YlxY from Bacillus subtilis and its bacterial homologs; Region: CE4_BsYlxY_like; cd10950
696281005541	NodB motif; other site
696281005542	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
696281005543	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
696281005544	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
696281005545	sporulation protein, YlmC/YmxH family; Region: spore_YlmC_YmxH; TIGR02888
696281005546	dihydrodipicolinate reductase; Provisional; Region: PRK00048
696281005547	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
696281005548	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
696281005549	dipicolinate synthase subunit A; Reviewed; Region: PRK08306
696281005550	Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240
696281005551	NAD binding site [chemical binding]; other site
696281005552	dipicolinate synthase subunit B; Reviewed; Region: spoVFB; PRK08305
696281005553	aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874
696281005554	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
696281005555	aspartate kinase I; Reviewed; Region: PRK08210
696281005556	Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452
696281005557	nucleotide binding site [chemical binding]; other site
696281005558	substrate binding site [chemical binding]; other site
696281005559	ACT domains of the diaminopimelate-sensitive aspartokinase (AK) isoenzyme AKI; Region: ACT_AKi-DapG-BS_1; cd04914
696281005560	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
696281005561	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
696281005562	dihydrodipicolinate synthase; Region: dapA; TIGR00674
696281005563	dimer interface [polypeptide binding]; other site
696281005564	active site
696281005565	catalytic residue [active]
696281005566	mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595
696281005567	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
696281005568	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
696281005569	Clp protease; Region: CLP_protease; pfam00574
696281005570	Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763
696281005571	active site
696281005572	YlzJ-like protein; Region: YlzJ; pfam14035
696281005573	Coat F domain; Region: Coat_F; pfam07875
696281005574	Domain of unknown function (DUF4117); Region: DUF4117; pfam13491
696281005575	DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674
696281005576	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
696281005577	Ftsk gamma domain; Region: Ftsk_gamma; pfam09397
696281005578	tRNA 2-selenouridine synthase; Provisional; Region: PRK11784
696281005579	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
696281005580	active site residue [active]
696281005581	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
696281005582	active site
696281005583	Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426
696281005584	Helix-turn-helix domain; Region: HTH_25; pfam13413
696281005585	Domain of unknown function (DUF4115); Region: DUF4115; pfam13464
696281005586	bacteriophage N4 adsorption protein B; Provisional; Region: PRK14716
696281005587	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
696281005588	active site
696281005589	Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632
696281005590	Recombinational DNA repair protein (RecF pathway) [DNA replication, recombination, and repair]; Region: RecR; COG0353
696281005591	DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481
696281005592	DNA protecting protein DprA; Region: dprA; TIGR00732
696281005593	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666
696281005594	Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740
696281005595	ribosomal protein S12 methylthiotransferase RimO; Region: TIGR01125
696281005596	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
696281005597	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
696281005598	FeS/SAM binding site; other site
696281005599	CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; Region: pgsA; TIGR00560
696281005600	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
696281005601	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
696281005602	Walker A motif; other site
696281005603	ATP binding site [chemical binding]; other site
696281005604	Walker B motif; other site
696281005605	arginine finger; other site
696281005606	Peptidase family M41; Region: Peptidase_M41; pfam01434
696281005607	competence damage-inducible protein A; Provisional; Region: PRK00549
696281005608	Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885
696281005609	putative MPT binding site; other site
696281005610	Competence-damaged protein; Region: CinA; pfam02464
696281005611	helicase 45; Provisional; Region: PTZ00424
696281005612	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
696281005613	ATP binding site [chemical binding]; other site
696281005614	Mg++ binding site [ion binding]; other site
696281005615	motif III; other site
696281005616	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
696281005617	nucleotide binding region [chemical binding]; other site
696281005618	ATP-binding site [chemical binding]; other site
696281005619	RNA recognition motif in the DbpA subfamily of prokaryotic DEAD-box rRNA helicases; Region: RRM_DbpA; cd12252
696281005620	RNA binding site [nucleotide binding]; other site
696281005621	recombinase A; Provisional; Region: recA; PRK09354
696281005622	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
696281005623	hexamer interface [polypeptide binding]; other site
696281005624	Walker A motif; other site
696281005625	ATP binding site [chemical binding]; other site
696281005626	Walker B motif; other site
696281005627	phosphodiesterase; Provisional; Region: PRK12704
696281005628	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
696281005629	Zn2+ binding site [ion binding]; other site
696281005630	Mg2+ binding site [ion binding]; other site
696281005631	Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382
696281005632	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
696281005633	putative active site [active]
696281005634	metal binding site [ion binding]; metal-binding site
696281005635	homodimer binding site [polypeptide binding]; other site
696281005636	Stage V sporulation protein S (SpoVS); Region: SpoVS; pfam04232
696281005637	Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355
696281005638	renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301
696281005639	active site
696281005640	dimer interface [polypeptide binding]; other site
696281005641	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438
696281005642	Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613
696281005643	active site
696281005644	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438
696281005645	LL-diaminopimelate aminotransferase; Provisional; Region: PRK09276
696281005646	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
696281005647	pyridoxal 5'-phosphate binding site [chemical binding]; other site
696281005648	homodimer interface [polypeptide binding]; other site
696281005649	catalytic residue [active]
696281005650	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
696281005651	Domain of unknown function (DUF3842); Region: DUF3842; pfam12953
696281005652	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215
696281005653	Zn2+ binding site [ion binding]; other site
696281005654	Mg2+ binding site [ion binding]; other site
696281005655	Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544
696281005656	homotrimer interface [polypeptide binding]; other site
696281005657	Walker A motif; other site
696281005658	GTP binding site [chemical binding]; other site
696281005659	Walker B motif; other site
696281005660	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
696281005661	catalytic core [active]
696281005662	Transcriptional regulator PadR-like family; Region: PadR; cl17335
696281005663	Predicted transcriptional regulators [Transcription]; Region: COG1695
696281005664	inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567
696281005665	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
696281005666	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein.  IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601
696281005667	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
696281005668	active site
696281005669	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
696281005670	Coenzyme A binding pocket [chemical binding]; other site
696281005671	Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196
696281005672	AAA domain; Region: AAA_31; pfam13614
696281005673	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
696281005674	G3 box; other site
696281005675	Switch II region; other site
696281005676	G4 box; other site
696281005677	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
696281005678	dimer interface [polypeptide binding]; other site
696281005679	ADP-ribose binding site [chemical binding]; other site
696281005680	active site
696281005681	nudix motif; other site
696281005682	metal binding site [ion binding]; metal-binding site
696281005683	septum formation inhibitor; Reviewed; Region: minC; PRK00513
696281005684	Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775
696281005685	carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459
696281005686	dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726
696281005687	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
696281005688	Ligand binding site; other site
696281005689	Putative Catalytic site; other site
696281005690	DXD motif; other site
696281005691	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
696281005692	G1P_cytidylyltransferase catalyzes the production of CDP-D-Glucose; Region: G1P_cytidylyltransferase; cd02524
696281005693	substrate binding site; other site
696281005694	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
696281005695	CDP-glucose 4,6-dehydratase; Region: CDP_4_6_dhtase; TIGR02622
696281005696	NAD(P) binding site [chemical binding]; other site
696281005697	active site
696281005698	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
696281005699	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
696281005700	NAD(P) binding site [chemical binding]; other site
696281005701	active site
696281005702	Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365
696281005703	Medium-chain acyl-CoA synthetase (MACS or ACSM); Region: MACS_like; cd05972
696281005704	active site
696281005705	acyl-activating enzyme (AAE) consensus motif; other site
696281005706	putative CoA binding site [chemical binding]; other site
696281005707	AMP binding site [chemical binding]; other site
696281005708	Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028
696281005709	Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039
696281005710	PYR/PP interface [polypeptide binding]; other site
696281005711	dimer interface [polypeptide binding]; other site
696281005712	tetramer interface [polypeptide binding]; other site
696281005713	TPP binding site [chemical binding]; other site
696281005714	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
696281005715	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629
696281005716	TPP-binding site [chemical binding]; other site
696281005717	NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976
696281005718	catalytic residues [active]
696281005719	Ferredoxin thioredoxin reductase catalytic beta chain; Region: FeThRed_B; cl01977
696281005720	(dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14328
696281005721	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
696281005722	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
696281005723	FeS/SAM binding site; other site
696281005724	Protein of unknown function (DUF964); Region: DUF964; pfam06133
696281005725	DNA mismatch repair protein MutS; Provisional; Region: PRK05399
696281005726	MutS domain I; Region: MutS_I; pfam01624
696281005727	MutS domain II; Region: MutS_II; pfam05188
696281005728	MutS domain III; Region: MutS_III; pfam05192
696281005729	ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284
696281005730	Walker A/P-loop; other site
696281005731	ATP binding site [chemical binding]; other site
696281005732	Q-loop/lid; other site
696281005733	ABC transporter signature motif; other site
696281005734	Walker B; other site
696281005735	D-loop; other site
696281005736	H-loop/switch region; other site
696281005737	N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145
696281005738	Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378
696281005739	Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968
696281005740	Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123
696281005741	Histone deacetylases and histone-like deacetylases, classII; Region: HDAC_classII; cd09992
696281005742	active site
696281005743	Zn binding site [ion binding]; other site
696281005744	DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095
696281005745	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
696281005746	ATP binding site [chemical binding]; other site
696281005747	Mg2+ binding site [ion binding]; other site
696281005748	G-X-G motif; other site
696281005749	MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782
696281005750	ATP binding site [chemical binding]; other site
696281005751	MutL C terminal dimerisation domain; Region: MutL_C; pfam08676
696281005752	Putative SAM-dependent methyltransferase; Region: SAM_MT; cl17517
696281005753	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
696281005754	tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091
696281005755	bacterial Hfq-like; Region: Hfq; cd01716
696281005756	hexamer interface [polypeptide binding]; other site
696281005757	Sm1 motif; other site
696281005758	RNA binding site [nucleotide binding]; other site
696281005759	Sm2 motif; other site
696281005760	stage V sporulation protein K; Region: spore_V_K; TIGR02881
696281005761	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
696281005762	Walker A motif; other site
696281005763	ATP binding site [chemical binding]; other site
696281005764	Walker B motif; other site
696281005765	arginine finger; other site
696281005766	Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100
696281005767	Aluminium resistance protein; Region: Alum_res; pfam06838
696281005768	sporulation lipoprotein, YhcN/YlaJ family; Region: spore_YhcN_YlaJ; TIGR02898
696281005769	Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580
696281005770	4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170
696281005771	substrate binding site [chemical binding]; other site
696281005772	multimerization interface [polypeptide binding]; other site
696281005773	ATP binding site [chemical binding]; other site
696281005774	Protein of unknown function (DUF1446); Region: DUF1446; pfam07287
696281005775	Domain of unknown function (DUF4387); Region: DUF4387; pfam14330
696281005776	Helix-Turn-Helix DNA binding domain of putative HspR-like transcription regulators; Region: HTH_HspR-like_MBC; cd04767
696281005777	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
696281005778	DNA binding residues [nucleotide binding]
696281005779	putative dimer interface [polypeptide binding]; other site
696281005780	putative metal binding residues [ion binding]; other site
696281005781	Predicted DNA-binding proteins [General function prediction only]; Region: COG1342
696281005782	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
696281005783	DNA binding residues [nucleotide binding]
696281005784	NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822
696281005785	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
696281005786	trimerization site [polypeptide binding]; other site
696281005787	active site
696281005788	This uncharacterized conserved protein belongs to a family of iron-molybdenum cluster-binding proteins that includes NifX, NifB, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of...; Region: MTH1175; cd00851
696281005789	MinD superfamily P-loop ATPase containing an inserted ferredoxin domain [Energy production and conversion]; Region: COG1149
696281005790	This protein family's function is unkown. It contains nucleotide binding site. It uses NTP as energy source to transfer electron or ion; Region: Fer4_NifH_child; cd03110
696281005791	P loop nucleotide binding; other site
696281005792	switch II; other site
696281005793	This protein family's function is unkown. It contains nucleotide binding site. It uses NTP as energy source to transfer electron or ion; Region: Fer4_NifH_child; cd03110
696281005794	P loop nucleotide binding; other site
696281005795	4Fe-4S dicluster domain; Region: Fer4_10; pfam13237
696281005796	switch II; other site
696281005797	This uncharacterized conserved protein belongs to a family of iron-molybdenum cluster-binding proteins that includes NifX, NifB, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of...; Region: MTH1175; cd00851
696281005798	LexA repressor; Validated; Region: PRK00215
696281005799	LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726
696281005800	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
696281005801	Catalytic site [active]
696281005802	PAS domain S-box; Region: sensory_box; TIGR00229
696281005803	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
696281005804	putative active site [active]
696281005805	heme pocket [chemical binding]; other site
696281005806	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221
696281005807	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
696281005808	Walker A motif; other site
696281005809	ATP binding site [chemical binding]; other site
696281005810	Walker B motif; other site
696281005811	arginine finger; other site
696281005812	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
696281005813	fumarate hydratase; Provisional; Region: PRK06246
696281005814	Fumarase C-terminus; Region: Fumerase_C; cl00795
696281005815	phosphoenolpyruvate carboxykinase; Provisional; Region: PRK09344
696281005816	Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293
696281005817	active site
696281005818	metal-binding site [ion binding]
696281005819	nucleotide-binding site [chemical binding]; other site
696281005820	Succinate:quinone oxidoreductase (SQR) Type B subfamily 1, transmembrane subunit; composed of proteins similar to Bacillus subtilis SQR. SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Bacillus subtilis...; Region: SQR_TypeB_1_TM; cd03497
696281005821	putative Iron-sulfur protein interface [polypeptide binding]; other site
696281005822	proximal heme binding site [chemical binding]; other site
696281005823	distal heme binding site [chemical binding]; other site
696281005824	putative dimer interface [polypeptide binding]; other site
696281005825	succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08641
696281005826	L-aspartate oxidase; Provisional; Region: PRK06175
696281005827	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
696281005828	succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK08640
696281005829	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085
696281005830	malate dehydrogenase; Reviewed; Region: PRK06223
696281005831	L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339
696281005832	NAD(P) binding site [chemical binding]; other site
696281005833	dimer interface [polypeptide binding]; other site
696281005834	tetramer (dimer of dimers) interface [polypeptide binding]; other site
696281005835	substrate binding site [chemical binding]; other site
696281005836	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
696281005837	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
696281005838	active site
696281005839	phosphorylation site [posttranslational modification]
696281005840	intermolecular recognition site; other site
696281005841	dimerization interface [polypeptide binding]; other site
696281005842	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
696281005843	DNA binding site [nucleotide binding]
696281005844	Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075
696281005845	Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772
696281005846	Transcriptional regulator PadR-like family; Region: PadR; cl17335
696281005847	Predicted transcriptional regulators [Transcription]; Region: COG1695
696281005848	RNA polymerase factor sigma C; Reviewed; Region: PRK09415
696281005849	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
696281005850	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
696281005851	DNA binding residues [nucleotide binding]
696281005852	PAS domain; Region: PAS; smart00091
696281005853	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
696281005854	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
696281005855	active site
696281005856	phosphorylation site [posttranslational modification]
696281005857	intermolecular recognition site; other site
696281005858	dimerization interface [polypeptide binding]; other site
696281005859	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
696281005860	DNA binding residues [nucleotide binding]
696281005861	dimerization interface [polypeptide binding]; other site
696281005862	CHASE3 domain; Region: CHASE3; cl05000
696281005863	PAS domain; Region: PAS_9; pfam13426
696281005864	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
696281005865	Histidine kinase; Region: HisKA_3; pfam07730
696281005866	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
696281005867	ATP binding site [chemical binding]; other site
696281005868	Mg2+ binding site [ion binding]; other site
696281005869	G-X-G motif; other site
696281005870	Predicted membrane protein [Function unknown]; Region: COG2855
696281005871	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
696281005872	Ligand Binding Site [chemical binding]; other site
696281005873	Putative ammonia monooxygenase [General function prediction only]; Region: AbrB; COG3180
696281005874	membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082
696281005875	membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082
696281005876	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
696281005877	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205
696281005878	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
696281005879	HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304
696281005880	dimerization interface [polypeptide binding]; other site
696281005881	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
696281005882	dimer interface [polypeptide binding]; other site
696281005883	phosphorylation site [posttranslational modification]
696281005884	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
696281005885	ATP binding site [chemical binding]; other site
696281005886	Mg2+ binding site [ion binding]; other site
696281005887	G-X-G motif; other site
696281005888	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
696281005889	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
696281005890	active site
696281005891	phosphorylation site [posttranslational modification]
696281005892	intermolecular recognition site; other site
696281005893	dimerization interface [polypeptide binding]; other site
696281005894	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
696281005895	Walker A motif; other site
696281005896	ATP binding site [chemical binding]; other site
696281005897	Walker B motif; other site
696281005898	arginine finger; other site
696281005899	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
696281005900	Protein of unknown function (DUF342); Region: DUF342; pfam03961
696281005901	Helix-turn-helix domain; Region: HTH_17; pfam12728
696281005902	PBP superfamily domain; Region: PBP_like; pfam12727
696281005903	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
696281005904	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
696281005905	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
696281005906	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
696281005907	dimer interface [polypeptide binding]; other site
696281005908	conserved gate region; other site
696281005909	putative PBP binding loops; other site
696281005910	ABC-ATPase subunit interface; other site
696281005911	ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839
696281005912	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
696281005913	Walker A/P-loop; other site
696281005914	ATP binding site [chemical binding]; other site
696281005915	Q-loop/lid; other site
696281005916	ABC transporter signature motif; other site
696281005917	Walker B; other site
696281005918	D-loop; other site
696281005919	H-loop/switch region; other site
696281005920	Domain of unknown function (DUF364); Region: DUF364; pfam04016
696281005921	Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076
696281005922	Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076
696281005923	UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472
696281005924	This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853
696281005925	Mg++ binding site [ion binding]; other site
696281005926	putative catalytic motif [active]
696281005927	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
696281005928	HAMP domain; Region: HAMP; pfam00672
696281005929	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
696281005930	dimer interface [polypeptide binding]; other site
696281005931	phosphorylation site [posttranslational modification]
696281005932	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
696281005933	ATP binding site [chemical binding]; other site
696281005934	Mg2+ binding site [ion binding]; other site
696281005935	G-X-G motif; other site
696281005936	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
696281005937	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
696281005938	active site
696281005939	phosphorylation site [posttranslational modification]
696281005940	intermolecular recognition site; other site
696281005941	dimerization interface [polypeptide binding]; other site
696281005942	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
696281005943	DNA binding site [nucleotide binding]
696281005944	poly-gamma-glutamate synthase PgsB/CapB; Region: poly_gGlu_PgsB; TIGR04012
696281005945	Protein of unknown function (DUF867); Region: DUF867; pfam05908
696281005946	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
696281005947	NlpC/P60 family; Region: NLPC_P60; cl17555
696281005948	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
696281005949	NlpC/P60 family; Region: NLPC_P60; pfam00877
696281005950	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
696281005951	NlpC/P60 family; Region: NLPC_P60; cl17555
696281005952	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
696281005953	NlpC/P60 family; Region: NLPC_P60; pfam00877
696281005954	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
696281005955	NlpC/P60 family; Region: NLPC_P60; pfam00877
696281005956	Protein of unknown function (DUF2680); Region: DUF2680; pfam10925
696281005957	Hydrogenase specific C-terminal endopeptidases, also called Hydrogen Maturation Proteases (H2MP). These enzymes belong to the peptidase family M52. Maturation of [FeNi] hydrogenases includes formation of the nickel metallocenter, proteolytic processing...; Region: H2MP; cd00518
696281005958	nickel binding site [ion binding]; other site
696281005959	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
696281005960	H+ Antiporter protein; Region: 2A0121; TIGR00900
696281005961	putative substrate translocation pore; other site
696281005962	phosphoenolpyruvate synthase; Validated; Region: PRK06241
696281005963	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
696281005964	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
696281005965	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
696281005966	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
696281005967	Domain of unknown function (DUF4317); Region: DUF4317; pfam14199
696281005968	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
696281005969	salt bridge; other site
696281005970	non-specific DNA binding site [nucleotide binding]; other site
696281005971	sequence-specific DNA binding site [nucleotide binding]; other site
696281005972	Protein of unknown function (DUF3036); Region: DUF3036; pfam11234
696281005973	Uncharacterized Fe-S center protein [General function prediction only]; Region: COG2768
696281005974	Uncharacterized conserved protein [Function unknown]; Region: COG2006
696281005975	4Fe-4S binding domain; Region: Fer4; pfam00037
696281005976	4Fe-4S binding domain; Region: Fer4; pfam00037
696281005977	Peptidylarginine deiminase and related enzymes [Amino acid transport and metabolism]; Region: COG2957; cl01113
696281005978	Porphyromonas-type peptidyl-arginine deiminase; Region: PAD_porph; pfam04371
696281005979	SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500
696281005980	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
696281005981	S-adenosylmethionine binding site [chemical binding]; other site
696281005982	Uncharacterized conserved protein [Function unknown]; Region: COG0398
696281005983	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
696281005984	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
696281005985	Response regulator receiver domain; Region: Response_reg; pfam00072
696281005986	active site
696281005987	phosphorylation site [posttranslational modification]
696281005988	intermolecular recognition site; other site
696281005989	dimerization interface [polypeptide binding]; other site
696281005990	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
696281005991	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
696281005992	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
696281005993	Sensory domain found in PocR; Region: PocR; pfam10114
696281005994	Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972
696281005995	Histidine kinase; Region: His_kinase; pfam06580
696281005996	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
696281005997	ATP binding site [chemical binding]; other site
696281005998	Mg2+ binding site [ion binding]; other site
696281005999	G-X-G motif; other site
696281006000	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
696281006001	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
696281006002	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
696281006003	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
696281006004	Walker A/P-loop; other site
696281006005	ATP binding site [chemical binding]; other site
696281006006	Q-loop/lid; other site
696281006007	ABC transporter signature motif; other site
696281006008	Walker B; other site
696281006009	D-loop; other site
696281006010	H-loop/switch region; other site
696281006011	First Helix-Turn-Helix DNA binding domain of the regulatory protein TioE; Region: HTH_TioE_rpt1; cd04772
696281006012	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
696281006013	DNA binding residues [nucleotide binding]
696281006014	putative dimer interface [polypeptide binding]; other site
696281006015	Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592
696281006016	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
696281006017	DNA binding residues [nucleotide binding]
696281006018	Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577
696281006019	1,2-propanediol utilization protein A (PduA), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduA; cd07059
696281006020	Hexamer interface [polypeptide binding]; other site
696281006021	Putative hexagonal pore residue; other site
696281006022	Propanediol utilization protein [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduL; COG4869
696281006023	Propanediol utilisation protein PduL; Region: PduL; pfam06130
696281006024	Propanediol utilisation protein PduL; Region: PduL; pfam06130
696281006025	Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122
696281006026	NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012
696281006027	putative catalytic cysteine [active]
696281006028	Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577
696281006029	Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045
696281006030	Hexamer interface [polypeptide binding]; other site
696281006031	Hexagonal pore residue; other site
696281006032	ethanolamine utilization protein EutQ; Provisional; Region: PRK15457
696281006033	Ethanolamine utilisation protein EutQ; Region: EutQ; pfam06249
696281006034	PduT-like ethanolamine utilization protein; Region: eut_PduT; TIGR02526
696281006035	1,2-propanediol utilization protein T (PduT), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_PduT_repeat1; cd07053
696281006036	putative hexamer interface [polypeptide binding]; other site
696281006037	putative hexagonal pore; other site
696281006038	1,2-propanediol utilization protein T (PduT), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_PduT_repeat2; cd07054
696281006039	putative hexamer interface [polypeptide binding]; other site
696281006040	putative hexagonal pore; other site
696281006041	Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512
696281006042	SLBB domain; Region: SLBB; pfam10531
696281006043	4Fe-4S dicluster domain; Region: Fer4_17; pfam13534
696281006044	M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393
696281006045	Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614
696281006046	Hexamer/Pentamer interface [polypeptide binding]; other site
696281006047	central pore; other site
696281006048	Bacterial Micro-Compartment (BMC) domain; Region: BMC; cl01982
696281006049	Hexamer interface [polypeptide binding]; other site
696281006050	Hexagonal pore residue; other site
696281006051	ethanolamine utilization protein EutJ; Provisional; Region: PRK15080
696281006052	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
696281006053	nucleotide binding site [chemical binding]; other site
696281006054	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
696281006055	nucleotide binding site [chemical binding]; other site
696281006056	Cobalamin adenosyltransferase; Region: Cob_adeno_trans; cl00920
696281006057	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882
696281006058	G1 box; other site
696281006059	GTP/Mg2+ binding site [chemical binding]; other site
696281006060	G2 box; other site
696281006061	Switch I region; other site
696281006062	G3 box; other site
696281006063	Switch II region; other site
696281006064	G4 box; other site
696281006065	G5 box; other site
696281006066	1,2-propanediol utilization protein U (PduU)/ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduU-EutS; cd07046
696281006067	putative hexamer interface [polypeptide binding]; other site
696281006068	putative hexagonal pore; other site
696281006069	glycyl-radical enzyme activating protein family; Region: PFLE_PFLC; TIGR02494
696281006070	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
696281006071	Multidrug resistance efflux transporter; Region: EmrE; pfam13536
696281006072	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
696281006073	EamA-like transporter family; Region: EamA; cl17759
696281006074	glycyl radical enzyme, PFL2/glycerol dehydratase family; Region: PFL2-3; TIGR01774
696281006075	Pyruvate formate lyase 2 and related enzymes; Region: PFL2_DhaB_BssA; cd01677
696281006076	dimer interface [polypeptide binding]; other site
696281006077	active site
696281006078	glycine loop; other site
696281006079	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
696281006080	1,3-propanediol dehydrogenase (PPD) catalyzes the reduction of 3-hydroxypropionaldehyde (3-HPA) to 1,3-propanediol in glycerol metabolism; Region: PDD; cd08180
696281006081	putative active site [active]
696281006082	metal binding site [ion binding]; metal-binding site
696281006083	Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122
696281006084	putative catalytic cysteine [active]
696281006085	Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577
696281006086	Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045
696281006087	Hexamer interface [polypeptide binding]; other site
696281006088	Hexagonal pore residue; other site
696281006089	Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577
696281006090	Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045
696281006091	Hexamer interface [polypeptide binding]; other site
696281006092	Hexagonal pore residue; other site
696281006093	Choline Kinase (ChoK). The ChoK subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: ChoK; cd05151
696281006094	Phosphotransferase enzyme family; Region: APH; pfam01636
696281006095	active site
696281006096	ATP binding site [chemical binding]; other site
696281006097	substrate binding site [chemical binding]; other site
696281006098	dimer interface [polypeptide binding]; other site
696281006099	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
696281006100	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
696281006101	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
696281006102	catalytic residues [active]
696281006103	Uncharacterized conserved protein [Function unknown]; Region: COG3379
696281006104	Uncharacterized conserved protein [Function unknown]; Region: COG3379
696281006105	Abortive infection C-terminus; Region: Abi_C; pfam14355
696281006106	putative RNA polymerase sigma factor SigI; Reviewed; Region: PRK08311
696281006107	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
696281006108	Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841
696281006109	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
696281006110	active site
696281006111	metal binding site [ion binding]; metal-binding site
696281006112	homotetramer interface [polypeptide binding]; other site
696281006113	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
696281006114	putative DNA binding site [nucleotide binding]; other site
696281006115	dimerization interface [polypeptide binding]; other site
696281006116	putative Zn2+ binding site [ion binding]; other site
696281006117	Arsenical resistance operon trans-acting repressor ArsD; Region: ArsD; pfam06953
696281006118	arsenical pump-driving ATPase; Region: arsen_driv_ArsA; TIGR04291
696281006119	ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
696281006120	P loop; other site
696281006121	Nucleotide binding site [chemical binding]; other site
696281006122	DTAP/Switch II; other site
696281006123	Switch I; other site
696281006124	ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
696281006125	P loop; other site
696281006126	Nucleotide binding site [chemical binding]; other site
696281006127	DTAP/Switch II; other site
696281006128	Switch I; other site
696281006129	Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798
696281006130	arsenical-resistance protein; Region: acr3; TIGR00832
696281006131	Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113
696281006132	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
696281006133	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143
696281006134	Transcriptional regulators [Transcription]; Region: MarR; COG1846
696281006135	MarR family; Region: MarR; pfam01047
696281006136	Cache domain; Region: Cache_1; pfam02743
696281006137	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
696281006138	dimerization interface [polypeptide binding]; other site
696281006139	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
696281006140	dimer interface [polypeptide binding]; other site
696281006141	Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015
696281006142	putative CheW interface [polypeptide binding]; other site
696281006143	Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518
696281006144	ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608
696281006145	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
696281006146	Walker A/P-loop; other site
696281006147	ATP binding site [chemical binding]; other site
696281006148	Q-loop/lid; other site
696281006149	ABC transporter signature motif; other site
696281006150	Walker B; other site
696281006151	D-loop; other site
696281006152	H-loop/switch region; other site
696281006153	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
696281006154	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
696281006155	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
696281006156	Walker A/P-loop; other site
696281006157	ATP binding site [chemical binding]; other site
696281006158	Q-loop/lid; other site
696281006159	ABC transporter signature motif; other site
696281006160	Walker B; other site
696281006161	D-loop; other site
696281006162	H-loop/switch region; other site
696281006163	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
696281006164	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
696281006165	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
696281006166	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
696281006167	dimer interface [polypeptide binding]; other site
696281006168	conserved gate region; other site
696281006169	putative PBP binding loops; other site
696281006170	ABC-ATPase subunit interface; other site
696281006171	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
696281006172	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
696281006173	dimer interface [polypeptide binding]; other site
696281006174	conserved gate region; other site
696281006175	putative PBP binding loops; other site
696281006176	ABC-ATPase subunit interface; other site
696281006177	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
696281006178	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512
696281006179	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
696281006180	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
696281006181	Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092
696281006182	active site
696281006183	Cupin domain; Region: Cupin_2; pfam07883
696281006184	N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146
696281006185	Hydantoinase B/oxoprolinase; Region: Hydantoinase_B; pfam02538
696281006186	N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145
696281006187	Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378
696281006188	Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968
696281006189	DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943
696281006190	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
696281006191	non-specific DNA binding site [nucleotide binding]; other site
696281006192	salt bridge; other site
696281006193	sequence-specific DNA binding site [nucleotide binding]; other site
696281006194	Cupin domain; Region: Cupin_2; pfam07883
696281006195	Predicted membrane protein (DUF2238); Region: DUF2238; pfam09997
696281006196	GDYXXLXY protein; Region: GDYXXLXY; pfam14345
696281006197	Predicted membrane protein (DUF2157); Region: DUF2157; pfam09925
696281006198	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
696281006199	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831
696281006200	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
696281006201	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
696281006202	Soluble P-type ATPase [General function prediction only]; Region: COG4087
696281006203	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
696281006204	CHASE3 domain; Region: CHASE3; cl05000
696281006205	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
696281006206	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
696281006207	dimerization interface [polypeptide binding]; other site
696281006208	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
696281006209	dimer interface [polypeptide binding]; other site
696281006210	Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015
696281006211	putative CheW interface [polypeptide binding]; other site
696281006212	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
696281006213	non-specific DNA binding site [nucleotide binding]; other site
696281006214	salt bridge; other site
696281006215	sequence-specific DNA binding site [nucleotide binding]; other site
696281006216	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
696281006217	non-specific DNA binding site [nucleotide binding]; other site
696281006218	salt bridge; other site
696281006219	sequence-specific DNA binding site [nucleotide binding]; other site
696281006220	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
696281006221	EamA-like transporter family; Region: EamA; pfam00892
696281006222	EamA-like transporter family; Region: EamA; pfam00892
696281006223	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
696281006224	Cysteine-rich domain; Region: CCG; pfam02754
696281006225	Cysteine-rich domain; Region: CCG; pfam02754
696281006226	FAD binding domain; Region: FAD_binding_4; pfam01565
696281006227	glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387
696281006228	short chain dehydrogenase; Provisional; Region: PRK06701
696281006229	classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355
696281006230	NAD binding site [chemical binding]; other site
696281006231	metal binding site [ion binding]; metal-binding site
696281006232	active site
696281006233	CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cl01482
696281006234	dimer interface [polypeptide binding]; other site
696281006235	3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250
696281006236	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
696281006237	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
696281006238	glycyl-radical enzyme activating protein family; Region: PFLE_PFLC; TIGR02494
696281006239	anaerobic ribonucleotide reductase-activating protein; Provisional; Region: nrdG; cl15804
696281006240	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
696281006241	FeS/SAM binding site; other site
696281006242	glycyl radical enzyme, PFL2/glycerol dehydratase family; Region: PFL2-3; TIGR01774
696281006243	Pyruvate formate lyase 2 and related enzymes; Region: PFL2_DhaB_BssA; cd01677
696281006244	dimer interface [polypeptide binding]; other site
696281006245	active site
696281006246	glycine loop; other site
696281006247	Transcriptional regulators [Transcription]; Region: GntR; COG1802
696281006248	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
696281006249	DNA-binding site [nucleotide binding]; DNA binding site
696281006250	FCD domain; Region: FCD; pfam07729
696281006251	GTPase RsgA; Reviewed; Region: PRK01889
696281006252	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
696281006253	RNA binding site [nucleotide binding]; other site
696281006254	Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854
696281006255	GTPase/Zn-binding domain interface [polypeptide binding]; other site
696281006256	GTP/Mg2+ binding site [chemical binding]; other site
696281006257	G4 box; other site
696281006258	G5 box; other site
696281006259	G1 box; other site
696281006260	Switch I region; other site
696281006261	G2 box; other site
696281006262	G3 box; other site
696281006263	Switch II region; other site
696281006264	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
696281006265	Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761
696281006266	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
696281006267	Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057
696281006268	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
696281006269	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
696281006270	Glycerol-3-phosphate responsive antiterminator; Region: G3P_antiterm; cl00852
696281006271	Predicted permeases [General function prediction only]; Region: COG0701
696281006272	TIGR03943 family protein; Region: TIGR03943
696281006273	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
696281006274	pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493
696281006275	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
696281006276	FeS/SAM binding site; other site
696281006277	Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076
696281006278	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
696281006279	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
696281006280	formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255
696281006281	Pyruvate formate lyase 1; Region: PFL1; cd01678
696281006282	coenzyme A binding site [chemical binding]; other site
696281006283	active site
696281006284	catalytic residues [active]
696281006285	glycine loop; other site
696281006286	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
696281006287	dimerization interface [polypeptide binding]; other site
696281006288	putative DNA binding site [nucleotide binding]; other site
696281006289	putative Zn2+ binding site [ion binding]; other site
696281006290	Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513
696281006291	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
696281006292	ATP binding site [chemical binding]; other site
696281006293	Mg++ binding site [ion binding]; other site
696281006294	motif III; other site
696281006295	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
696281006296	nucleotide binding region [chemical binding]; other site
696281006297	ATP-binding site [chemical binding]; other site
696281006298	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
696281006299	active site
696281006300	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
696281006301	germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887
696281006302	Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504
696281006303	Spore germination protein; Region: Spore_permease; cl17796
696281006304	Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323
696281006305	Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019
696281006306	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Ornithine Decarboxylase; Region: PLPDE_III_ODC; cd00622
696281006307	dimer interface [polypeptide binding]; other site
696281006308	active site
696281006309	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
696281006310	catalytic residues [active]
696281006311	substrate binding site [chemical binding]; other site
696281006312	Yqey-like protein; Region: YqeY; pfam09424
696281006313	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
696281006314	Major Facilitator Superfamily; Region: MFS_1; pfam07690
696281006315	putative substrate translocation pore; other site
696281006316	Transglycosylase; Region: Transgly; pfam00912
696281006317	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
696281006318	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
696281006319	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
696281006320	This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1; Region: GT1_UGDG_like; cd03817
696281006321	putative ADP-binding pocket [chemical binding]; other site
696281006322	Late competence development protein ComFB; Region: ComFB; pfam10719
696281006323	6-phosphofructokinase; Region: PFKA_ATP; TIGR02482
696281006324	phosphofructokinase; Region: PFK_mixed; TIGR02483
696281006325	active site
696281006326	ADP/pyrophosphate binding site [chemical binding]; other site
696281006327	dimerization interface [polypeptide binding]; other site
696281006328	allosteric effector site; other site
696281006329	fructose-1,6-bisphosphate binding site; other site
696281006330	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
696281006331	Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_12; cd06347
696281006332	putative ligand binding site [chemical binding]; other site
696281006333	Uncharacterized conserved protein [Function unknown]; Region: COG1615
696281006334	Uncharacterized protein family (UPF0182); Region: UPF0182; pfam03699
696281006335	threonine synthase; Validated; Region: PRK06450
696281006336	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
696281006337	D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372
696281006338	ATP-grasp domain; Region: ATP-grasp_4; cl17255
696281006339	[FeFe] hydrogenase, group B1/B3; Region: FeFe_hydrog_B1; TIGR04105
696281006340	4Fe-4S binding domain; Region: Fer4; pfam00037
696281006341	4Fe-4S binding domain; Region: Fer4; pfam00037
696281006342	Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906
696281006343	Nitrogen regulatory protein P-II; Region: P-II; smart00938
696281006344	Protein of unknown function (DUF1538); Region: DUF1538; pfam07556
696281006345	Protein of unknown function (DUF1538); Region: DUF1538; pfam07556
696281006346	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205
696281006347	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
696281006348	metal-binding site [ion binding]
696281006349	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
696281006350	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
696281006351	metal-binding site [ion binding]
696281006352	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
696281006353	Soluble P-type ATPase [General function prediction only]; Region: COG4087
696281006354	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
696281006355	metal-binding site [ion binding]
696281006356	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
696281006357	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
696281006358	metal-binding site [ion binding]
696281006359	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
696281006360	haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710
696281006361	zinc transporter ZupT; Provisional; Region: PRK04201
696281006362	ZIP Zinc transporter; Region: Zip; pfam02535
696281006363	Transposase; Region: DEDD_Tnp_IS110; pfam01548
696281006364	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
696281006365	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
696281006366	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
696281006367	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
696281006368	Protein of unknown function (DUF2512); Region: DUF2512; pfam10710
696281006369	Thiamine biosynthesis enzyme ThiH and related uncharacterized enzymes [Coenzyme metabolism / General function prediction only]; Region: ThiH; COG1060
696281006370	Biotin and Thiamin Synthesis associated domain; Region: BATS; cl06149
696281006371	Minimal MMP-like domain found in Thermus thermophilus hypothetical protein TTHA0227 and similar proteins; Region: MMP_TTHA0227; cd12953
696281006372	phosphoenolpyruvate synthase; Validated; Region: PRK06241
696281006373	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
696281006374	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
696281006375	EamA-like transporter family; Region: EamA; pfam00892
696281006376	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
696281006377	EamA-like transporter family; Region: EamA; pfam00892
696281006378	Putative cyclase; Region: Cyclase; pfam04199
696281006379	Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535
696281006380	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
696281006381	FeS/SAM binding site; other site
696281006382	Domain of unknown function (DUF4008); Region: DUF4008; pfam13186
696281006383	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812
696281006384	hydrophobic ligand binding site; other site
696281006385	hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466
696281006386	uncharacterized subgroup of aldehyde reductase and flavonoid reductase related proteins, extended (e) SDRs; Region: AR_FR_like_1_SDR_e; cd05228
696281006387	putative NADP binding site [chemical binding]; other site
696281006388	putative substrate binding site [chemical binding]; other site
696281006389	active site
696281006390	Methyltransferase domain; Region: Methyltransf_23; pfam13489
696281006391	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
696281006392	S-adenosylmethionine binding site [chemical binding]; other site
696281006393	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
696281006394	3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304
696281006395	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
696281006396	dimer interface [polypeptide binding]; other site
696281006397	active site
696281006398	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
696281006399	beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150
696281006400	dimer interface [polypeptide binding]; other site
696281006401	active site
696281006402	Protein of unknown function (DUF422); Region: DUF422; cl00991
696281006403	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
696281006404	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
696281006405	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
696281006406	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
696281006407	Walker A/P-loop; other site
696281006408	ATP binding site [chemical binding]; other site
696281006409	Q-loop/lid; other site
696281006410	ABC transporter signature motif; other site
696281006411	Walker B; other site
696281006412	D-loop; other site
696281006413	H-loop/switch region; other site
696281006414	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
696281006415	putative efflux pump membrane fusion protein; Provisional; Region: PRK03598
696281006416	The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; Region: BAR; cl12013
696281006417	HlyD family secretion protein; Region: HlyD_3; pfam13437
696281006418	Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170
696281006419	elongation factor G; Reviewed; Region: PRK12740
696281006420	G1 box; other site
696281006421	putative GEF interaction site [polypeptide binding]; other site
696281006422	GTP/Mg2+ binding site [chemical binding]; other site
696281006423	Switch I region; other site
696281006424	G2 box; other site
696281006425	G3 box; other site
696281006426	Switch II region; other site
696281006427	G4 box; other site
696281006428	G5 box; other site
696281006429	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
696281006430	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
696281006431	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
696281006432	stage V sporulation protein B; Region: spore_V_B; TIGR02900
696281006433	Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124
696281006434	oxidase reductase; Provisional; Region: PTZ00273
696281006435	5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346
696281006436	Protein of unknown function (DUF4264); Region: DUF4264; pfam14084
696281006437	GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate.  The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria.  In...; Region: GTP_cyclohydro1; cd00642
696281006438	homodecamer interface [polypeptide binding]; other site
696281006439	GTP cyclohydrolase I; Provisional; Region: PLN03044
696281006440	active site
696281006441	putative catalytic site residues [active]
696281006442	zinc binding site [ion binding]; other site
696281006443	GTP-CH-I/GFRP interaction surface; other site
696281006444	Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602
696281006445	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
696281006446	FeS/SAM binding site; other site
696281006447	Domain of unknown function (DUF366); Region: DUF366; pfam04017
696281006448	Predicted PP-loop superfamily ATPase [General function prediction only]; Region: COG0603
696281006449	Ligand Binding Site [chemical binding]; other site
696281006450	6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242
696281006451	active site
696281006452	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
696281006453	TPR motif; other site
696281006454	TPR repeat; Region: TPR_11; pfam13414
696281006455	TPR repeat; Region: TPR_11; pfam13414
696281006456	TPR repeat; Region: TPR_11; pfam13414
696281006457	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
696281006458	binding surface
696281006459	TPR motif; other site
696281006460	TPR repeat; Region: TPR_11; pfam13414
696281006461	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
696281006462	binding surface
696281006463	TPR repeat; Region: TPR_11; pfam13414
696281006464	TPR motif; other site
696281006465	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
696281006466	Tetratricopeptide repeat; Region: TPR_16; pfam13432
696281006467	binding surface
696281006468	TPR motif; other site
696281006469	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
696281006470	Coenzyme A binding pocket [chemical binding]; other site
696281006471	Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492
696281006472	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
696281006473	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
696281006474	metal-binding site [ion binding]
696281006475	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
696281006476	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
696281006477	metal-binding site [ion binding]
696281006478	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
696281006479	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
696281006480	metal-binding site [ion binding]
696281006481	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
696281006482	Soluble P-type ATPase [General function prediction only]; Region: COG4087
696281006483	radical SAM protein, TatD family-associated; Region: tatD_link_rSAM; TIGR04038
696281006484	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
696281006485	FeS/SAM binding site; other site
696281006486	putative membrane protein, TIGR04086 family; Region: TIGR04086_membr
696281006487	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
696281006488	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
696281006489	dimer interface [polypeptide binding]; other site
696281006490	phosphorylation site [posttranslational modification]
696281006491	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
696281006492	ATP binding site [chemical binding]; other site
696281006493	Mg2+ binding site [ion binding]; other site
696281006494	G-X-G motif; other site
696281006495	Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183
696281006496	Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558
696281006497	bifunctional ATP-dependent DNA helicase/DNA polymerase III subunit epsilon; Validated; Region: PRK08074
696281006498	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
696281006499	active site
696281006500	catalytic site [active]
696281006501	substrate binding site [chemical binding]; other site
696281006502	CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cl17460
696281006503	Helicase C-terminal domain; Region: Helicase_C_2; pfam13307
696281006504	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317
696281006505	active site
696281006506	thiamine biosynthesis protein ThiH; Reviewed; Region: thiH; PRK09613
696281006507	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
696281006508	FeS/SAM binding site; other site
696281006509	Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876
696281006510	Uncharacterized family 3; belongs to a superfamily containing the transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this family was previously known as part of DUF156; Region: CsoR-like_DUF156_3; cd10160
696281006511	putative homodimer interface [polypeptide binding]; other site
696281006512	putative homotetramer interface [polypeptide binding]; other site
696281006513	putative metal binding site [ion binding]; other site
696281006514	putative homodimer-homodimer interface [polypeptide binding]; other site
696281006515	heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525
696281006516	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
696281006517	Soluble P-type ATPase [General function prediction only]; Region: COG4087
696281006518	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
696281006519	dimerization interface [polypeptide binding]; other site
696281006520	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
696281006521	dimer interface [polypeptide binding]; other site
696281006522	phosphorylation site [posttranslational modification]
696281006523	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
696281006524	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
696281006525	ATP binding site [chemical binding]; other site
696281006526	Mg2+ binding site [ion binding]; other site
696281006527	G-X-G motif; other site
696281006528	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
696281006529	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
696281006530	active site
696281006531	phosphorylation site [posttranslational modification]
696281006532	intermolecular recognition site; other site
696281006533	dimerization interface [polypeptide binding]; other site
696281006534	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
696281006535	DNA binding site [nucleotide binding]
696281006536	Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076
696281006537	Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076
696281006538	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
696281006539	Predicted permease; Region: DUF318; cl17795
696281006540	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489
696281006541	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
696281006542	Walker A motif; other site
696281006543	Rrf2 family protein; Region: rrf2_super; TIGR00738
696281006544	Transcriptional regulator; Region: Rrf2; pfam02082
696281006545	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143
696281006546	multidrug efflux pump VmrA; Reviewed; Region: vmrA; PRK09575
696281006547	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
696281006548	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
696281006549	DNA binding residues [nucleotide binding]
696281006550	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
696281006551	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
696281006552	metal-dependent hydrolase; Provisional; Region: PRK00685
696281006553	succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678
696281006554	CoA binding domain; Region: CoA_binding; pfam02629
696281006555	CoA-ligase; Region: Ligase_CoA; pfam00549
696281006556	succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696
696281006557	ATP-grasp domain; Region: ATP-grasp_2; pfam08442
696281006558	CoA-ligase; Region: Ligase_CoA; pfam00549
696281006559	Transcriptional regulator of aromatic amino acids metabolism [Transcription / Amino acid transport and metabolism]; Region: TyrR; COG3283
696281006560	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
696281006561	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
696281006562	putative active site [active]
696281006563	heme pocket [chemical binding]; other site
696281006564	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
696281006565	Walker A motif; other site
696281006566	ATP binding site [chemical binding]; other site
696281006567	Walker B motif; other site
696281006568	arginine finger; other site
696281006569	Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl17212
696281006570	butyrate kinase; Provisional; Region: PRK03011
696281006571	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
696281006572	Transcriptional regulator [Transcription]; Region: IclR; COG1414
696281006573	Bacterial transcriptional regulator; Region: IclR; pfam01614
696281006574	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
696281006575	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
696281006576	DNA binding site [nucleotide binding]
696281006577	DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595
696281006578	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
696281006579	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
696281006580	DNA binding residues [nucleotide binding]
696281006581	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
696281006582	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
696281006583	active site
696281006584	phosphorylation site [posttranslational modification]
696281006585	intermolecular recognition site; other site
696281006586	dimerization interface [polypeptide binding]; other site
696281006587	LytTr DNA-binding domain; Region: LytTR; smart00850
696281006588	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
696281006589	DNA-binding interface [nucleotide binding]; DNA binding site
696281006590	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
696281006591	HTH-like domain; Region: HTH_21; pfam13276
696281006592	Integrase core domain; Region: rve; pfam00665
696281006593	Integrase core domain; Region: rve_3; pfam13683
696281006594	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
696281006595	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
696281006596	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
696281006597	HEAT repeats; Region: HEAT_2; pfam13646
696281006598	germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887
696281006599	Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504
696281006600	Spore germination protein; Region: Spore_permease; cl17796
696281006601	Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323
696281006602	Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546
696281006603	2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867
696281006604	Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375
696281006605	TPP-binding site [chemical binding]; other site
696281006606	2-oxoglutarate ferredoxin oxidoreductase subunit alpha; Validated; Region: PRK08659
696281006607	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
696281006608	dimer interface [polypeptide binding]; other site
696281006609	PYR/PP interface [polypeptide binding]; other site
696281006610	TPP binding site [chemical binding]; other site
696281006611	substrate binding site [chemical binding]; other site
696281006612	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
696281006613	4Fe-4S dicluster domain; Region: Fer4_10; pfam13237
696281006614	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
696281006615	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
696281006616	hydroxyglutarate oxidase; Provisional; Region: PRK11728
696281006617	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
696281006618	2-oxoacid:acceptor oxidoreductase, delta subunit, pyruvate/2-ketoisovalerate family; Region: PorD_KorD; TIGR02179
696281006619	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
696281006620	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
696281006621	catalytic loop [active]
696281006622	iron binding site [ion binding]; other site
696281006623	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205
696281006624	PAS domain S-box; Region: sensory_box; TIGR00229
696281006625	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
696281006626	putative active site [active]
696281006627	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
696281006628	psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974
696281006629	Walker A motif; other site
696281006630	ATP binding site [chemical binding]; other site
696281006631	Walker B motif; other site
696281006632	arginine finger; other site
696281006633	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
696281006634	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
696281006635	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
696281006636	Walker A/P-loop; other site
696281006637	ATP binding site [chemical binding]; other site
696281006638	Q-loop/lid; other site
696281006639	ABC transporter signature motif; other site
696281006640	Walker B; other site
696281006641	D-loop; other site
696281006642	H-loop/switch region; other site
696281006643	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
696281006644	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
696281006645	Walker A/P-loop; other site
696281006646	ATP binding site [chemical binding]; other site
696281006647	Q-loop/lid; other site
696281006648	ABC transporter signature motif; other site
696281006649	Walker B; other site
696281006650	D-loop; other site
696281006651	H-loop/switch region; other site
696281006652	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
696281006653	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
696281006654	TM-ABC transporter signature motif; other site
696281006655	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
696281006656	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
696281006657	TM-ABC transporter signature motif; other site
696281006658	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
696281006659	Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_12; cd06347
696281006660	putative ligand binding site [chemical binding]; other site
696281006661	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
696281006662	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
696281006663	PAS domain; Region: PAS_9; pfam13426
696281006664	psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974
696281006665	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
696281006666	Walker A motif; other site
696281006667	ATP binding site [chemical binding]; other site
696281006668	Walker B motif; other site
696281006669	arginine finger; other site
696281006670	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
696281006671	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
696281006672	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
696281006673	Walker A/P-loop; other site
696281006674	ATP binding site [chemical binding]; other site
696281006675	Q-loop/lid; other site
696281006676	ABC transporter signature motif; other site
696281006677	Walker B; other site
696281006678	D-loop; other site
696281006679	H-loop/switch region; other site
696281006680	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
696281006681	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
696281006682	Walker A/P-loop; other site
696281006683	ATP binding site [chemical binding]; other site
696281006684	Q-loop/lid; other site
696281006685	ABC transporter signature motif; other site
696281006686	Walker B; other site
696281006687	D-loop; other site
696281006688	H-loop/switch region; other site
696281006689	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
696281006690	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
696281006691	TM-ABC transporter signature motif; other site
696281006692	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
696281006693	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
696281006694	TM-ABC transporter signature motif; other site
696281006695	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
696281006696	Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_12; cd06347
696281006697	putative ligand binding site [chemical binding]; other site
696281006698	putative transposase OrfB; Reviewed; Region: PHA02517
696281006699	HTH-like domain; Region: HTH_21; pfam13276
696281006700	Integrase core domain; Region: rve; pfam00665
696281006701	Integrase core domain; Region: rve_2; pfam13333
696281006702	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
696281006703	Transposase; Region: HTH_Tnp_1; cl17663
696281006704	Helix-turn-helix domain; Region: HTH_28; pfam13518
696281006705	Purine nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pnp; COG0005
696281006706	adenylate kinase; Reviewed; Region: adk; PRK00279
696281006707	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
696281006708	AMP-binding site [chemical binding]; other site
696281006709	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
696281006710	ABC-type ATPase fused to a predicted acetyltransferase domain [General function prediction only]; Region: COG2401
696281006711	Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036
696281006712	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
696281006713	substrate binding site [chemical binding]; other site
696281006714	hexamer interface [polypeptide binding]; other site
696281006715	metal binding site [ion binding]; metal-binding site
696281006716	GTPase RsgA; Reviewed; Region: PRK00098
696281006717	S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466
696281006718	RNA binding site [nucleotide binding]; other site
696281006719	homodimer interface [polypeptide binding]; other site
696281006720	Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854
696281006721	GTPase/Zn-binding domain interface [polypeptide binding]; other site
696281006722	GTP/Mg2+ binding site [chemical binding]; other site
696281006723	G4 box; other site
696281006724	G5 box; other site
696281006725	G1 box; other site
696281006726	Switch I region; other site
696281006727	G2 box; other site
696281006728	G3 box; other site
696281006729	Switch II region; other site
696281006730	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
696281006731	Catalytic domain of Protein Kinases; Region: PKc; cd00180
696281006732	active site
696281006733	ATP binding site [chemical binding]; other site
696281006734	substrate binding site [chemical binding]; other site
696281006735	activation loop (A-loop); other site
696281006736	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
696281006737	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
696281006738	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
696281006739	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
696281006740	Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772
696281006741	Protein phosphatase 2C; Region: PP2C; pfam00481
696281006742	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
696281006743	active site
696281006744	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
696281006745	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
696281006746	phosphopeptide binding site; other site
696281006747	Protein of unknown function (DUF2662); Region: DUF3662; pfam12401
696281006748	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
696281006749	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
696281006750	phosphopeptide binding site; other site
696281006751	ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14454
696281006752	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
696281006753	FeS/SAM binding site; other site
696281006754	16S rRNA methyltransferase B; Provisional; Region: PRK14902
696281006755	NusB family; Region: NusB; pfam01029
696281006756	putative RNA binding site [nucleotide binding]; other site
696281006757	FtsJ-like methyltransferase; Region: FtsJ; cl17430
696281006758	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
696281006759	S-adenosylmethionine binding site [chemical binding]; other site
696281006760	Protein of unknown function DUF116; Region: DUF116; pfam01976
696281006761	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
696281006762	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
696281006763	putative active site [active]
696281006764	substrate binding site [chemical binding]; other site
696281006765	putative cosubstrate binding site; other site
696281006766	catalytic site [active]
696281006767	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
696281006768	substrate binding site [chemical binding]; other site
696281006769	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
696281006770	active site
696281006771	catalytic residues [active]
696281006772	metal binding site [ion binding]; metal-binding site
696281006773	primosome assembly protein PriA; Validated; Region: PRK05580
696281006774	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
696281006775	DNA binding residues [nucleotide binding]
696281006776	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
696281006777	ATP binding site [chemical binding]; other site
696281006778	putative Mg++ binding site [ion binding]; other site
696281006779	helicase superfamily c-terminal domain; Region: HELICc; smart00490
696281006780	nucleotide binding region [chemical binding]; other site
696281006781	bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579
696281006782	Flavoprotein; Region: Flavoprotein; pfam02441
696281006783	DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127
696281006784	DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392
696281006785	Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194
696281006786	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
696281006787	catalytic site [active]
696281006788	G-X2-G-X-G-K; other site
696281006789	hypothetical protein; Provisional; Region: PRK04323
696281006790	hypothetical protein; Provisional; Region: PRK11820
696281006791	YicC-like family, N-terminal region; Region: YicC_N; pfam03755
696281006792	Domain of unknown function (DUF1732); Region: DUF1732; pfam08340
696281006793	Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755
696281006794	aspartate aminotransferase; Provisional; Region: PRK05764
696281006795	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
696281006796	pyridoxal 5'-phosphate binding site [chemical binding]; other site
696281006797	homodimer interface [polypeptide binding]; other site
696281006798	catalytic residue [active]
696281006799	LL-diaminopimelate aminotransferase; Provisional; Region: PRK09276
696281006800	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
696281006801	pyridoxal 5'-phosphate binding site [chemical binding]; other site
696281006802	homodimer interface [polypeptide binding]; other site
696281006803	catalytic residue [active]
696281006804	diaminopimelate epimerase; Provisional; Region: dapF; PRK00450
696281006805	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
696281006806	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
696281006807	23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088
696281006808	Methyltransferase domain; Region: Methyltransf_11; pfam08241
696281006809	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
696281006810	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831
696281006811	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
696281006812	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
696281006813	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
696281006814	motif II; other site
696281006815	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
696281006816	Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833
696281006817	Domain of unknown function (DUF814); Region: DUF814; pfam05670
696281006818	Uncharacterized conserved protein [Function unknown]; Region: COG3379
696281006819	Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663
696281006820	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
696281006821	active site
696281006822	lipoprotein signal peptidase; Provisional; Region: PRK14787
696281006823	Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458
696281006824	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725
696281006825	active site
696281006826	dimer interface [polypeptide binding]; other site
696281006827	dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037
696281006828	Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740
696281006829	heterodimer interface [polypeptide binding]; other site
696281006830	active site
696281006831	FMN binding site [chemical binding]; other site
696281006832	homodimer interface [polypeptide binding]; other site
696281006833	substrate binding site [chemical binding]; other site
696281006834	dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054
696281006835	FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218
696281006836	FAD binding pocket [chemical binding]; other site
696281006837	FAD binding motif [chemical binding]; other site
696281006838	phosphate binding motif [ion binding]; other site
696281006839	beta-alpha-beta structure motif; other site
696281006840	NAD binding pocket [chemical binding]; other site
696281006841	Iron coordination center [ion binding]; other site
696281006842	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
696281006843	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
696281006844	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
696281006845	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
696281006846	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
696281006847	ATP-grasp domain; Region: ATP-grasp_4; cl17255
696281006848	Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424
696281006849	IMP binding site; other site
696281006850	dimer interface [polypeptide binding]; other site
696281006851	interdomain contacts; other site
696281006852	partial ornithine binding site; other site
696281006853	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
696281006854	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988
696281006855	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
696281006856	catalytic site [active]
696281006857	subunit interface [polypeptide binding]; other site
696281006858	dihydroorotase; Validated; Region: pyrC; PRK09357
696281006859	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
696281006860	Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317
696281006861	active site
696281006862	aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856
696281006863	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
696281006864	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
696281006865	Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065
696281006866	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
696281006867	active site
696281006868	Protein of unknown function (DUF2619); Region: DUF2619; pfam10942
696281006869	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
696281006870	Major Facilitator Superfamily; Region: MFS_1; pfam07690
696281006871	putative substrate translocation pore; other site
696281006872	(2R)-phospho-3-sulfolactate synthase (ComA); Region: ComA; pfam02679
696281006873	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
696281006874	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
696281006875	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
696281006876	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
696281006877	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
696281006878	Walker A/P-loop; other site
696281006879	ATP binding site [chemical binding]; other site
696281006880	Q-loop/lid; other site
696281006881	ABC transporter signature motif; other site
696281006882	Walker B; other site
696281006883	D-loop; other site
696281006884	H-loop/switch region; other site
696281006885	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
696281006886	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
696281006887	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
696281006888	Walker A/P-loop; other site
696281006889	ATP binding site [chemical binding]; other site
696281006890	Q-loop/lid; other site
696281006891	ABC transporter signature motif; other site
696281006892	Walker B; other site
696281006893	D-loop; other site
696281006894	H-loop/switch region; other site
696281006895	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
696281006896	non-specific DNA binding site [nucleotide binding]; other site
696281006897	salt bridge; other site
696281006898	sequence-specific DNA binding site [nucleotide binding]; other site
696281006899	Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662
696281006900	Uncharacterized conserved protein [Function unknown]; Region: COG5646
696281006901	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
696281006902	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
696281006903	metal binding site [ion binding]; metal-binding site
696281006904	active site
696281006905	I-site; other site
696281006906	Spore germination protein; Region: Spore_permease; cl17796
696281006907	Spore germination protein; Region: Spore_permease; cl17796
696281006908	Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323
696281006909	germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887
696281006910	Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504
696281006911	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
696281006912	active site
696281006913	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
696281006914	active site
696281006915	FMN binding site [chemical binding]; other site
696281006916	substrate binding site [chemical binding]; other site
696281006917	3Fe-4S cluster binding site [ion binding]; other site
696281006918	Protein of unknown function (DUF441); Region: DUF441; pfam04284
696281006919	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
696281006920	Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375
696281006921	Hydrogenase expression/synthesis hypA family; Region: HypA; pfam01155
696281006922	Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypE; COG0309
696281006923	HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis.  HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197
696281006924	dimerization interface [polypeptide binding]; other site
696281006925	ATP binding site [chemical binding]; other site
696281006926	hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075
696281006927	hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062
696281006928	HupF/HypC family; Region: HupF_HypC; pfam01455
696281006929	Acylphosphatase; Region: Acylphosphatase; pfam00708
696281006930	Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068
696281006931	HypF finger; Region: zf-HYPF; pfam07503
696281006932	HypF finger; Region: zf-HYPF; pfam07503
696281006933	Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300
696281006934	coenzyme F420-reducing hydrogenase delta subunit (putative coenzyme F420 hydrogenase processing subunit); Region: frhD; TIGR00130
696281006935	Hydrogenase specific C-terminal endopeptidases, also called Hydrogen Maturation Proteases (H2MP). These enzymes belong to the peptidase family M52. Maturation of [FeNi] hydrogenases includes formation of the nickel metallocenter, proteolytic processing...; Region: H2MP; cd00518
696281006936	nickel binding site [ion binding]; other site
696281006937	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859
696281006938	Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374
696281006939	Nickel-dependent hydrogenase; Region: NiFeSe_Hases; pfam00374
696281006940	Ni,Fe-hydrogenase I small subunit [Energy production and conversion]; Region: HyaA; COG1740
696281006941	NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058
696281006942	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
696281006943	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
696281006944	RNA binding surface [nucleotide binding]; other site
696281006945	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
696281006946	active site
696281006947	Uncharacterized proteins with similarity to Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL_like_DUF711; cd08025
696281006948	ACT domain proteins similar to the yet uncharacterized Streptococcus pneumoniae ACT domain protein; Region: ACT_1ZPV; cd04872
696281006949	preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022
696281006950	SecD/SecF GG Motif; Region: Sec_GG; pfam07549
696281006951	Protein export membrane protein; Region: SecD_SecF; pfam02355
696281006952	protein-export membrane protein SecD; Region: secD; TIGR01129
696281006953	protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916
696281006954	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
696281006955	Zn2+ binding site [ion binding]; other site
696281006956	Mg2+ binding site [ion binding]; other site
696281006957	Preprotein translocase subunit; Region: YajC; pfam02699
696281006958	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112
696281006959	Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343
696281006960	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147
696281006961	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113
696281006962	Protein of unknown function (DUF2905); Region: DUF2905; pfam11146
696281006963	Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases and ATP sulphurylases. The domain forms a apha/beta/apha fold which  binds to Adenosine group; Region: Alpha_ANH_like; cd01986
696281006964	Ligand Binding Site [chemical binding]; other site
696281006965	Reovirus sigma C capsid protein; Region: Reo_sigmaC; pfam04582
696281006966	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
696281006967	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
696281006968	Walker A motif; other site
696281006969	ATP binding site [chemical binding]; other site
696281006970	Walker B motif; other site
696281006971	arginine finger; other site
696281006972	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
696281006973	Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116
696281006974	RuvA N terminal domain; Region: RuvA_N; pfam01330
696281006975	RuvA, C-terminal domain; Region: RuvA_C; pfam07499
696281006976	Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529
696281006977	active site
696281006978	putative DNA-binding cleft [nucleotide binding]; other site
696281006979	dimer interface [polypeptide binding]; other site
696281006980	hypothetical protein; Validated; Region: PRK00110
696281006981	NAD synthetase; Provisional; Region: PRK13980
696281006982	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
696281006983	homodimer interface [polypeptide binding]; other site
696281006984	NAD binding pocket [chemical binding]; other site
696281006985	ATP binding pocket [chemical binding]; other site
696281006986	Mg binding site [ion binding]; other site
696281006987	active-site loop [active]
696281006988	Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257
696281006989	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064
696281006990	putative dimer interface [polypeptide binding]; other site
696281006991	[2Fe-2S] cluster binding site [ion binding]; other site
696281006992	Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980
696281006993	dimer interface [polypeptide binding]; other site
696281006994	[2Fe-2S] cluster binding site [ion binding]; other site
696281006995	NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894
696281006996	SLBB domain; Region: SLBB; pfam10531
696281006997	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589
696281006998	4Fe-4S binding domain; Region: Fer4; pfam00037
696281006999	4Fe-4S dicluster domain; Region: Fer4_10; pfam13237
696281007000	bidirectional hydrogenase complex protein HoxU; Validated; Region: PRK07569
696281007001	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
696281007002	catalytic loop [active]
696281007003	iron binding site [ion binding]; other site
696281007004	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588
696281007005	[FeFe] hydrogenase, group A; Region: FeFe_hydrog_A; TIGR02512
696281007006	Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906
696281007007	Iron hydrogenase small subunit; Region: Fe_hyd_SSU; pfam02256
696281007008	Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257
696281007009	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064
696281007010	putative dimer interface [polypeptide binding]; other site
696281007011	[2Fe-2S] cluster binding site [ion binding]; other site
696281007012	Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980
696281007013	dimer interface [polypeptide binding]; other site
696281007014	[2Fe-2S] cluster binding site [ion binding]; other site
696281007015	NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894
696281007016	SLBB domain; Region: SLBB; pfam10531
696281007017	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928
696281007018	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
696281007019	catalytic loop [active]
696281007020	iron binding site [ion binding]; other site
696281007021	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588
696281007022	[FeFe] hydrogenase, group A; Region: FeFe_hydrog_A; TIGR02512
696281007023	Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906
696281007024	Iron hydrogenase small subunit; Region: Fe_hyd_SSU; pfam02256
696281007025	TGF-beta propeptide; Region: TGFb_propeptide; pfam00688
696281007026	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
696281007027	active site
696281007028	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
696281007029	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
696281007030	active site
696281007031	UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511
696281007032	putative metal binding site; other site
696281007033	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
696281007034	binding surface
696281007035	type IV pilus biogenesis/stability protein PilW; Region: type_IV_pilW; TIGR02521
696281007036	TPR motif; other site
696281007037	UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511
696281007038	putative metal binding site; other site
696281007039	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
696281007040	binding surface
696281007041	TPR motif; other site
696281007042	TPR repeat; Region: TPR_11; pfam13414
696281007043	UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511
696281007044	putative metal binding site; other site
696281007045	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
696281007046	binding surface
696281007047	TPR motif; other site
696281007048	Tetratricopeptide repeat; Region: TPR_12; pfam13424
696281007049	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
696281007050	binding surface
696281007051	TPR motif; other site
696281007052	Flagellin N-methylase; Region: FliB; cl00497
696281007053	Ethanolamine utilisation protein EutA; Region: EutA; pfam06277
696281007054	ethanolamine ammonia-lyase small subunit; Provisional; Region: PRK05465
696281007055	ethanolamine ammonia lyase large subunit; Provisional; Region: PRK15067
696281007056	Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; pfam06751
696281007057	ethanolamine permease; Region: 2A0305; TIGR00908
696281007058	Response regulator receiver domain; Region: Response_reg; pfam00072
696281007059	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
696281007060	active site
696281007061	phosphorylation site [posttranslational modification]
696281007062	intermolecular recognition site; other site
696281007063	dimerization interface [polypeptide binding]; other site
696281007064	Signal transduction histidine kinase; Region: H_kinase_N; pfam12282
696281007065	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
696281007066	Histidine kinase; Region: HisKA_2; pfam07568
696281007067	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
696281007068	ATP binding site [chemical binding]; other site
696281007069	Mg2+ binding site [ion binding]; other site
696281007070	G-X-G motif; other site
696281007071	Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707
696281007072	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
696281007073	active site
696281007074	phosphorylation site [posttranslational modification]
696281007075	intermolecular recognition site; other site
696281007076	dimerization interface [polypeptide binding]; other site
696281007077	ANTAR domain; Region: ANTAR; pfam03861
696281007078	dihydroxy-acid dehydratase; Provisional; Region: PRK00911
696281007079	C-terminal binding protein (CtBP), D-isomer-specific 2-hydroxyacid dehydrogenases related repressor; Region: CtBP_dh; cd05299
696281007080	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
696281007081	ligand binding site [chemical binding]; other site
696281007082	NAD binding site [chemical binding]; other site
696281007083	catalytic site [active]
696281007084	2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800
696281007085	KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452
696281007086	active site
696281007087	intersubunit interface [polypeptide binding]; other site
696281007088	catalytic residue [active]
696281007089	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
696281007090	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
696281007091	substrate binding site [chemical binding]; other site
696281007092	ATP binding site [chemical binding]; other site
696281007093	2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800
696281007094	KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452
696281007095	active site
696281007096	intersubunit interface [polypeptide binding]; other site
696281007097	catalytic residue [active]
696281007098	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
696281007099	Transcriptional regulator [Transcription]; Region: IclR; COG1414
696281007100	Bacterial transcriptional regulator; Region: IclR; pfam01614
696281007101	Domain of unknown function (DUF2088); Region: DUF2088; cl15406
696281007102	DctM-like transporters; Region: DctM; pfam06808
696281007103	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593
696281007104	TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090
696281007105	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
696281007106	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480
696281007107	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
696281007108	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
696281007109	NAD(P) binding site [chemical binding]; other site
696281007110	gluconate 5-dehydrogenase; Provisional; Region: PRK08213
696281007111	gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347
696281007112	NADP binding site [chemical binding]; other site
696281007113	homodimer interface [polypeptide binding]; other site
696281007114	active site
696281007115	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
696281007116	Predicted membrane protein [Function unknown]; Region: COG2364
696281007117	Sporulation protein YunB (Spo_YunB); Region: Spore_YunB; cl09783
696281007118	Transglycosylase; Region: Transgly; pfam00912
696281007119	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
696281007120	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
696281007121	putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272
696281007122	EamA-like transporter family; Region: EamA; pfam00892
696281007123	EamA-like transporter family; Region: EamA; pfam00892
696281007124	ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866
696281007125	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
696281007126	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
696281007127	Walker A/P-loop; other site
696281007128	ATP binding site [chemical binding]; other site
696281007129	Q-loop/lid; other site
696281007130	ABC transporter signature motif; other site
696281007131	Walker B; other site
696281007132	D-loop; other site
696281007133	H-loop/switch region; other site
696281007134	Putative zinc-finger; Region: zf-HC2; pfam13490
696281007135	Domain of unknown function (DUF4367); Region: DUF4367; pfam14285
696281007136	RNA polymerase sigma factor SigX; Provisional; Region: PRK09639
696281007137	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
696281007138	DNA binding residues [nucleotide binding]
696281007139	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
696281007140	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
696281007141	metal binding site [ion binding]; metal-binding site
696281007142	active site
696281007143	I-site; other site
696281007144	Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385
696281007145	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
696281007146	putative active site [active]
696281007147	putative metal binding site [ion binding]; other site
696281007148	Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257
696281007149	Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305
696281007150	E-class dimer interface [polypeptide binding]; other site
696281007151	P-class dimer interface [polypeptide binding]; other site
696281007152	active site
696281007153	Cu2+ binding site [ion binding]; other site
696281007154	Zn2+ binding site [ion binding]; other site
696281007155	EVE domain; Region: EVE; pfam01878
696281007156	ABC-type transport system involved in cytochrome bd biosynthesis, fused ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydC; COG4987
696281007157	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
696281007158	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
696281007159	Walker A/P-loop; other site
696281007160	ATP binding site [chemical binding]; other site
696281007161	Q-loop/lid; other site
696281007162	ABC transporter signature motif; other site
696281007163	Walker B; other site
696281007164	D-loop; other site
696281007165	H-loop/switch region; other site
696281007166	thiol reductant ABC exporter, CydD subunit; Region: CydD; TIGR02857
696281007167	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
696281007168	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
696281007169	Walker A/P-loop; other site
696281007170	ATP binding site [chemical binding]; other site
696281007171	Q-loop/lid; other site
696281007172	ABC transporter signature motif; other site
696281007173	Walker B; other site
696281007174	D-loop; other site
696281007175	H-loop/switch region; other site
696281007176	Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322
696281007177	cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219
696281007178	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654
696281007179	cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097
696281007180	Rrf2 family protein; Region: rrf2_super; TIGR00738
696281007181	Transcriptional regulator; Region: Rrf2; pfam02082
696281007182	Salmonella virulence plasmid 28.1kDa A protein; Region: VRP1; pfam03538
696281007183	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
696281007184	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
696281007185	Coenzyme A binding pocket [chemical binding]; other site
696281007186	recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409
696281007187	MutS domain III; Region: MutS_III; pfam05192
696281007188	ATP-binding cassette domain of MutS2; Region: ABC_MutS2; cd03280
696281007189	Walker A/P-loop; other site
696281007190	ATP binding site [chemical binding]; other site
696281007191	Q-loop/lid; other site
696281007192	ABC transporter signature motif; other site
696281007193	Walker B; other site
696281007194	D-loop; other site
696281007195	H-loop/switch region; other site
696281007196	ATP synthase B/B' CF(0); Region: ATP-synt_B; pfam00430
696281007197	Smr domain; Region: Smr; pfam01713
696281007198	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
696281007199	Peptidase family U32; Region: Peptidase_U32; pfam01136
696281007200	Collagenase; Region: DUF3656; pfam12392
696281007201	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
696281007202	Peptidase family U32; Region: Peptidase_U32; pfam01136
696281007203	Uncharacterized conserved protein [Function unknown]; Region: COG0327
696281007204	NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371
696281007205	Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540
696281007206	active site
696281007207	DNA binding site [nucleotide binding]
696281007208	Nucleotidyltransferase (NT) domain of family X DNA Polymerases; Region: NT_POLXc; cd00141
696281007209	hypothetical protein; Provisional; Region: PRK08609
696281007210	active site
696281007211	primer binding site [nucleotide binding]; other site
696281007212	NTP  binding site [chemical binding]; other site
696281007213	metal binding triad [ion binding]; metal-binding site
696281007214	Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436
696281007215	active site
696281007216	Cell division protein ZapA; Region: ZapA; cl01146
696281007217	4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnF; Provisional; Region: PRK02971
696281007218	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
696281007219	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
696281007220	putative tRNA-binding site [nucleotide binding]; other site
696281007221	B3/4 domain; Region: B3_4; pfam03483
696281007222	tRNA synthetase B5 domain; Region: B5; smart00874
696281007223	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
696281007224	dimer interface [polypeptide binding]; other site
696281007225	motif 1; other site
696281007226	motif 3; other site
696281007227	motif 2; other site
696281007228	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147
696281007229	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
696281007230	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
696281007231	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
696281007232	dimer interface [polypeptide binding]; other site
696281007233	motif 1; other site
696281007234	active site
696281007235	motif 2; other site
696281007236	motif 3; other site
696281007237	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
696281007238	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967
696281007239	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
696281007240	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
696281007241	TrkA-N domain; Region: TrkA_N; pfam02254
696281007242	TrkA-C domain; Region: TrkA_C; pfam02080
696281007243	Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168
696281007244	potassium uptake protein, TrkH family; Region: 2a38; TIGR00933
696281007245	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
696281007246	23S rRNA binding site [nucleotide binding]; other site
696281007247	L21 binding site [polypeptide binding]; other site
696281007248	L13 binding site [polypeptide binding]; other site
696281007249	50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172
696281007250	translation initiation factor IF-3; Region: infC; TIGR00168
696281007251	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
696281007252	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
696281007253	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413
696281007254	TGS _ThrRS_N:  ThrRS (threonyl-tRNA Synthetase)  is a class II tRNA synthetase that couples threonine to its cognate tRNA.  In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667
696281007255	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973
696281007256	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
696281007257	active site
696281007258	dimer interface [polypeptide binding]; other site
696281007259	motif 1; other site
696281007260	motif 2; other site
696281007261	motif 3; other site
696281007262	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
696281007263	anticodon binding site; other site
696281007264	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399
696281007265	Protein of unknown function (DUF445); Region: DUF445; pfam04286
696281007266	YtxC-like family; Region: YtxC; pfam08812
696281007267	Serine dehydrogenase proteinase; Region: SDH_sah; pfam01972
696281007268	Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763
696281007269	active site
696281007270	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
696281007271	lipoyl attachment site [posttranslational modification]; other site
696281007272	FOG: CBS domain [General function prediction only]; Region: COG0517
696281007273	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205
696281007274	PAS fold; Region: PAS; pfam00989
696281007275	psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974
696281007276	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
696281007277	Walker A motif; other site
696281007278	ATP binding site [chemical binding]; other site
696281007279	Walker B motif; other site
696281007280	arginine finger; other site
696281007281	Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322
696281007282	Na binding site [ion binding]; other site
696281007283	Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765
696281007284	dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416
696281007285	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
696281007286	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
696281007287	Staphylococcal nuclease homologues; Region: SNc; smart00318
696281007288	Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175
696281007289	Catalytic site; other site
696281007290	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
696281007291	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686
696281007292	Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936
696281007293	Putative catalytic NodB homology domain of Bacillus subtilis putative polysaccharide deacetylase PdaB, and its bacterial homologs; Region: CE4_BsPdaB_like; cd10949
696281007294	NodB motif; other site
696281007295	putative active site [active]
696281007296	putative catalytic site [active]
696281007297	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
696281007298	Uncharacterized conserved protein [Function unknown]; Region: COG0398
696281007299	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
696281007300	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
696281007301	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
696281007302	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
696281007303	C-terminal peptidase (prc); Region: prc; TIGR00225
696281007304	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
696281007305	protein binding site [polypeptide binding]; other site
696281007306	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
696281007307	Catalytic dyad [active]
696281007308	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
696281007309	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
696281007310	DNA polymerase I; Provisional; Region: PRK05755
696281007311	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
696281007312	active site
696281007313	metal binding site 1 [ion binding]; metal-binding site
696281007314	putative 5' ssDNA interaction site; other site
696281007315	metal binding site 3; metal-binding site
696281007316	metal binding site 2 [ion binding]; metal-binding site
696281007317	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
696281007318	putative DNA binding site [nucleotide binding]; other site
696281007319	putative metal binding site [ion binding]; other site
696281007320	inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140
696281007321	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
696281007322	active site
696281007323	DNA binding site [nucleotide binding]
696281007324	catalytic site [active]
696281007325	formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103
696281007326	N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966
696281007327	DNA binding site [nucleotide binding]
696281007328	catalytic residue [active]
696281007329	H2TH interface [polypeptide binding]; other site
696281007330	putative catalytic residues [active]
696281007331	turnover-facilitating residue; other site
696281007332	intercalation triad [nucleotide binding]; other site
696281007333	8OG recognition residue [nucleotide binding]; other site
696281007334	putative reading head residues; other site
696281007335	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
696281007336	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
696281007337	putative sporulation protein YtaF; Region: spore_YtaF; TIGR02840
696281007338	Domain of unknown function DUF; Region: DUF204; pfam02659
696281007339	Domain of unknown function DUF; Region: DUF204; pfam02659
696281007340	Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237
696281007341	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
696281007342	CoA-binding site [chemical binding]; other site
696281007343	ATP-binding [chemical binding]; other site
696281007344	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
696281007345	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
696281007346	N-acetyl-D-glucosamine binding site [chemical binding]; other site
696281007347	catalytic residue [active]
696281007348	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
696281007349	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
696281007350	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
696281007351	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
696281007352	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
696281007353	ATP-binding cassette domain of the lipid transporters, subfamily A; Region: ABC_subfamily_A; cd03263
696281007354	Walker A/P-loop; other site
696281007355	ATP binding site [chemical binding]; other site
696281007356	Q-loop/lid; other site
696281007357	ABC transporter signature motif; other site
696281007358	Walker B; other site
696281007359	D-loop; other site
696281007360	H-loop/switch region; other site
696281007361	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
696281007362	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
696281007363	Walker A/P-loop; other site
696281007364	ATP binding site [chemical binding]; other site
696281007365	Q-loop/lid; other site
696281007366	ABC transporter signature motif; other site
696281007367	Walker B; other site
696281007368	D-loop; other site
696281007369	H-loop/switch region; other site
696281007370	putative efflux pump membrane fusion protein; Provisional; Region: PRK03598
696281007371	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
696281007372	HlyD family secretion protein; Region: HlyD_3; pfam13437
696281007373	[FeFe] hydrogenase, group A; Region: FeFe_hydrog_A; TIGR02512
696281007374	Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906
696281007375	Putative Fe-S cluster; Region: FeS; cl17515
696281007376	PAS fold; Region: PAS; pfam00989
696281007377	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
696281007378	putative active site [active]
696281007379	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
696281007380	Coat F domain; Region: Coat_F; pfam07875
696281007381	Domain of unknown function (DUF2935); Region: DUF2935; pfam11155
696281007382	Domain of unknown function (DUF2935); Region: DUF2935; pfam11155
696281007383	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
696281007384	IHF dimer interface [polypeptide binding]; other site
696281007385	IHF - DNA interface [nucleotide binding]; other site
696281007386	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
696281007387	non-specific DNA binding site [nucleotide binding]; other site
696281007388	salt bridge; other site
696281007389	sequence-specific DNA binding site [nucleotide binding]; other site
696281007390	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
696281007391	mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479
696281007392	active site
696281007393	Cupin domain; Region: Cupin_2; cl17218
696281007394	Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215
696281007395	CESA_like_2 is a member of the cellulose synthase superfamily; Region: CESA_like_2; cd06427
696281007396	DXD motif; other site
696281007397	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
696281007398	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
696281007399	Ligand binding site; other site
696281007400	Putative Catalytic site; other site
696281007401	DXD motif; other site
696281007402	DNA topoisomerase III; Provisional; Region: PRK07726
696281007403	TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362
696281007404	active site
696281007405	putative interdomain interaction site [polypeptide binding]; other site
696281007406	putative metal-binding site [ion binding]; other site
696281007407	putative nucleotide binding site [chemical binding]; other site
696281007408	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
696281007409	domain I; other site
696281007410	DNA binding groove [nucleotide binding]
696281007411	phosphate binding site [ion binding]; other site
696281007412	domain II; other site
696281007413	domain III; other site
696281007414	nucleotide binding site [chemical binding]; other site
696281007415	catalytic site [active]
696281007416	domain IV; other site
696281007417	C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342
696281007418	C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342
696281007419	Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283
696281007420	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
696281007421	NAD binding site [chemical binding]; other site
696281007422	catalytic Zn binding site [ion binding]; other site
696281007423	structural Zn binding site [ion binding]; other site
696281007424	Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508
696281007425	Coenzyme A binding pocket [chemical binding]; other site
696281007426	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
696281007427	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
696281007428	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
696281007429	putative dimer interface [polypeptide binding]; other site
696281007430	Transcriptional regulator [Transcription]; Region: LysR; COG0583
696281007431	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
696281007432	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
696281007433	dimerization interface [polypeptide binding]; other site
696281007434	CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311
696281007435	substrate binding site [chemical binding]; other site
696281007436	THF binding site; other site
696281007437	zinc-binding site [ion binding]; other site
696281007438	L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948
696281007439	Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316
696281007440	active site pocket [active]
696281007441	nucleoside diphosphate kinase regulator; Provisional; Region: PRK05753
696281007442	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
696281007443	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
696281007444	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
696281007445	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
696281007446	PAS fold; Region: PAS_3; pfam08447
696281007447	putative active site [active]
696281007448	heme pocket [chemical binding]; other site
696281007449	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
696281007450	PAS fold; Region: PAS_3; pfam08447
696281007451	putative active site [active]
696281007452	heme pocket [chemical binding]; other site
696281007453	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
696281007454	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
696281007455	dimer interface [polypeptide binding]; other site
696281007456	putative CheW interface [polypeptide binding]; other site
696281007457	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
696281007458	Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644
696281007459	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
696281007460	BclB C-terminal domain; Region: exospore_TM; TIGR03721
696281007461	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
696281007462	UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511
696281007463	putative metal binding site; other site
696281007464	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
696281007465	binding surface
696281007466	TPR motif; other site
696281007467	FOG: CBS domain [General function prediction only]; Region: COG0517
696281007468	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
696281007469	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
696281007470	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
696281007471	putative substrate translocation pore; other site
696281007472	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
696281007473	HlyD family secretion protein; Region: HlyD_3; pfam13437
696281007474	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
696281007475	HlyD family secretion protein; Region: HlyD_3; pfam13437
696281007476	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
696281007477	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
696281007478	Walker A/P-loop; other site
696281007479	ATP binding site [chemical binding]; other site
696281007480	Q-loop/lid; other site
696281007481	ABC transporter signature motif; other site
696281007482	Walker B; other site
696281007483	D-loop; other site
696281007484	H-loop/switch region; other site
696281007485	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
696281007486	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
696281007487	FtsX-like permease family; Region: FtsX; pfam02687
696281007488	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
696281007489	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
696281007490	active site
696281007491	phosphorylation site [posttranslational modification]
696281007492	intermolecular recognition site; other site
696281007493	dimerization interface [polypeptide binding]; other site
696281007494	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
696281007495	DNA binding site [nucleotide binding]
696281007496	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066
696281007497	Iron only nitrogenase protein AnfO (AnfO_nitrog); Region: AnfO_nitrog; cl17112
696281007498	Integrase core domain; Region: rve; pfam00665
696281007499	NAD-dependent deacetylase; Provisional; Region: PRK00481
696281007500	SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195
696281007501	PilZ domain; Region: PilZ; cl01260
696281007502	Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536
696281007503	ligand binding site [chemical binding]; other site
696281007504	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
696281007505	Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908
696281007506	putative ADP-ribose binding site [chemical binding]; other site
696281007507	putative active site [active]
696281007508	Uncharacterized protein family UPF0047; Region: UPF0047; pfam01894
696281007509	heat shock protein 90; Provisional; Region: PRK05218
696281007510	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
696281007511	ATP binding site [chemical binding]; other site
696281007512	Mg2+ binding site [ion binding]; other site
696281007513	G-X-G motif; other site
696281007514	germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887
696281007515	Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504
696281007516	Spore germination protein; Region: Spore_permease; cl17796
696281007517	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
696281007518	Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323
696281007519	Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055
696281007520	Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the...; Region: P_permease; cd01116
696281007521	transmembrane helices; other site
696281007522	peroxiredoxin; Provisional; Region: PRK13189
696281007523	Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by...; Region: PRX_1cys; cd03016
696281007524	dimer interface [polypeptide binding]; other site
696281007525	decamer (pentamer of dimers) interface [polypeptide binding]; other site
696281007526	catalytic triad [active]
696281007527	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
696281007528	nudix motif; other site
696281007529	Domain of unknown function (DUF4363); Region: DUF4363; pfam14276
696281007530	Predicted membrane protein [Function unknown]; Region: COG2323
696281007531	Protein of unknown function (DUF1657); Region: DUF1657; pfam07870
696281007532	Protein of unknown function (DUF1657); Region: DUF1657; pfam07870
696281007533	Predicted membrane protein [Function unknown]; Region: COG2323
696281007534	Protein of unknown function (DUF1657); Region: DUF1657; pfam07870
696281007535	stage V sporulation protein AC; Region: spore_V_AC; TIGR02838
696281007536	stage V sporulation protein AD; Provisional; Region: PRK12404
696281007537	Stage V sporulation protein AD (SpoVAD); Region: SpoVAD; pfam07451
696281007538	stage V sporulation protein AE; Region: spore_V_AE; TIGR02839
696281007539	Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580
696281007540	Restriction endonuclease BglII; Region: Endonuc-BglII; pfam09195
696281007541	NAD synthetase; Provisional; Region: PRK13981
696281007542	Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570
696281007543	multimer interface [polypeptide binding]; other site
696281007544	active site
696281007545	catalytic triad [active]
696281007546	protein interface 1 [polypeptide binding]; other site
696281007547	Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which  binds to Adenosine nucleotide; Region: AANH_like; cl00292
696281007548	4-alpha-glucanotransferase; Provisional; Region: PRK14508
696281007549	N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857
696281007550	homodimer interface [polypeptide binding]; other site
696281007551	maltodextrin glucosidase; Provisional; Region: PRK10785
696281007552	Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338
696281007553	active site
696281007554	homodimer interface [polypeptide binding]; other site
696281007555	catalytic site [active]
696281007556	glycogen synthase; Provisional; Region: glgA; PRK00654
696281007557	This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791
696281007558	ADP-binding pocket [chemical binding]; other site
696281007559	homodimer interface [polypeptide binding]; other site
696281007560	glucose-1-phosphate adenylyltransferase, GlgD subunit; Region: glgD; TIGR02092
696281007561	ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508
696281007562	ligand binding site; other site
696281007563	oligomer interface; other site
696281007564	Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651
696281007565	dimer interface [polypeptide binding]; other site
696281007566	N-terminal domain interface [polypeptide binding]; other site
696281007567	sulfate 1 binding site; other site
696281007568	glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK05293
696281007569	ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508
696281007570	ligand binding site; other site
696281007571	oligomer interface; other site
696281007572	Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651
696281007573	dimer interface [polypeptide binding]; other site
696281007574	N-terminal domain interface [polypeptide binding]; other site
696281007575	sulfate 1 binding site; other site
696281007576	glycogen branching enzyme; Provisional; Region: PRK12313
696281007577	N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855
696281007578	Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322
696281007579	active site
696281007580	catalytic site [active]
696281007581	Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806
696281007582	Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077
696281007583	Prephenate dehydratase; Region: PDT; pfam00800
696281007584	C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905
696281007585	putative L-Phe binding site [chemical binding]; other site
696281007586	Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075
696281007587	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
696281007588	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
696281007589	dimer interface [polypeptide binding]; other site
696281007590	putative CheW interface [polypeptide binding]; other site
696281007591	Cache domain; Region: Cache_1; pfam02743
696281007592	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
696281007593	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
696281007594	Zn2+ binding site [ion binding]; other site
696281007595	Mg2+ binding site [ion binding]; other site
696281007596	Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020
696281007597	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230
696281007598	catalytic residue [active]
696281007599	putative FPP diphosphate  binding site; other site
696281007600	putative FPP binding hydrophobic cleft; other site
696281007601	dimer interface [polypeptide binding]; other site
696281007602	putative IPP diphosphate binding site; other site
696281007603	Domain of unknown function (DUF4365); Region: DUF4365; pfam14280
696281007604	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
696281007605	Cysteine-rich domain; Region: CCG; pfam02754
696281007606	Nitrate reductase gamma subunit; Region: Nitrate_red_gam; cl00959
696281007607	Predicted O-methyltransferase [General function prediction only]; Region: COG4122
696281007608	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
696281007609	S-adenosylmethionine binding site [chemical binding]; other site
696281007610	LysR transcriptional regulator; Provisional; Region: rbcR; CHL00180
696281007611	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
696281007612	C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420
696281007613	putative dimerization interface [polypeptide binding]; other site
696281007614	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
696281007615	[FeFe] hydrogenase, group A; Region: FeFe_hydrog_A; TIGR02512
696281007616	Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906
696281007617	Iron hydrogenase small subunit; Region: Fe_hyd_SSU; pfam02256
696281007618	DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951
696281007619	Polysulphide reductase [Energy production and conversion]; Region: COG5557; cl17901
696281007620	Flagellin N-methylase; Region: FliB; pfam03692
696281007621	Iron only hydrogenase large subunit, C-terminal domain [General function prediction only]; Region: COG4624
696281007622	Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906
696281007623	flavoprotein, HI0933 family; Region: TIGR00275
696281007624	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
696281007625	Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509
696281007626	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
696281007627	galactoside O-acetyltransferase; Reviewed; Region: lacA; PRK09527
696281007628	Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357
696281007629	active site
696281007630	substrate binding site [chemical binding]; other site
696281007631	trimer interface [polypeptide binding]; other site
696281007632	CoA binding site [chemical binding]; other site
696281007633	The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456
696281007634	GIY-YIG motif/motif A; other site
696281007635	putative active site [active]
696281007636	putative metal binding site [ion binding]; other site
696281007637	Metal-dependent hydrolases of the beta-lactamase superfamily II [General function prediction only]; Region: COG1237
696281007638	Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer,  utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514
696281007639	FMN binding site [chemical binding]; other site
696281007640	dimer interface [polypeptide binding]; other site
696281007641	Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer,  utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cd02062
696281007642	dimer interface [polypeptide binding]; other site
696281007643	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268
696281007644	Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  These two proteins are lipid raft-associated.  Individual proteins of...; Region: Band_7_flotillin; cd03399
696281007645	NfeD-like C-terminal, partner-binding; Region: NfeD; cl00686
696281007646	Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842
696281007647	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
696281007648	Major Facilitator Superfamily; Region: MFS_1; pfam07690
696281007649	putative substrate translocation pore; other site
696281007650	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
696281007651	Major Facilitator Superfamily; Region: MFS_1; pfam07690
696281007652	putative substrate translocation pore; other site
696281007653	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
696281007654	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
696281007655	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
696281007656	ABC transporter; Region: ABC_tran_2; pfam12848
696281007657	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
696281007658	FOG: CBS domain [General function prediction only]; Region: COG0517
696281007659	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205
696281007660	Nuclease-related domain; Region: NERD; pfam08378
696281007661	superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280
696281007662	heme-binding site [chemical binding]; other site
696281007663	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
696281007664	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
696281007665	dimer interface [polypeptide binding]; other site
696281007666	putative CheW interface [polypeptide binding]; other site
696281007667	recombination factor protein RarA; Reviewed; Region: PRK13342
696281007668	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
696281007669	Walker A motif; other site
696281007670	ATP binding site [chemical binding]; other site
696281007671	Walker B motif; other site
696281007672	arginine finger; other site
696281007673	MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
696281007674	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
696281007675	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
696281007676	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
696281007677	metal ion-dependent adhesion site (MIDAS); other site
696281007678	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
696281007679	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
696281007680	Walker A motif; other site
696281007681	ATP binding site [chemical binding]; other site
696281007682	Walker B motif; other site
696281007683	arginine finger; other site
696281007684	helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785
696281007685	hypothetical protein; Provisional; Region: PRK09947
696281007686	Family description; Region: UvrD_C_2; pfam13538
696281007687	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
696281007688	helicase-exonuclease AddAB, AddB subunit; Region: addB_Gpos; TIGR02773
696281007689	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
696281007690	Penicillinase repressor; Region: Pencillinase_R; pfam03965
696281007691	BlaR1 peptidase M56; Region: Peptidase_M56; pfam05569
696281007692	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
696281007693	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
696281007694	active site
696281007695	metal binding site [ion binding]; metal-binding site
696281007696	Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498
696281007697	Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560
696281007698	pyridoxal 5'-phosphate binding site [chemical binding]; other site
696281007699	catalytic residue [active]
696281007700	Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113
696281007701	N-carbamoylputrescine amidohydrolase (CPA) (class 11 nitrilases); Region: CPA; cd07573
696281007702	N-carbamoylputrescine amidase; Region: agmatine_aguB; TIGR03381
696281007703	putative active site; other site
696281007704	catalytic triad [active]
696281007705	putative dimer interface [polypeptide binding]; other site
696281007706	Peptidylarginine deiminase and related enzymes [Amino acid transport and metabolism]; Region: COG2957; cl01113
696281007707	Porphyromonas-type peptidyl-arginine deiminase; Region: PAD_porph; pfam04371
696281007708	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
696281007709	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
696281007710	Cysteine-rich domain; Region: CCG; pfam02754
696281007711	Cysteine-rich domain; Region: CCG; pfam02754
696281007712	glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387
696281007713	FAD binding domain; Region: FAD_binding_4; pfam01565
696281007714	Uncharacterized conserved protein [Function unknown]; Region: COG1633
696281007715	Uncharacterized family of ferritin-like proteins found in archaea and bacteria; Region: Ferritin_like_AB; cd01045
696281007716	diiron binding motif [ion binding]; other site
696281007717	Uncharacterized BCR, YaiI/YqxD family COG1671; Region: DUF188; cl00727
696281007718	Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849
696281007719	Cell division protein FtsA; Region: FtsA; smart00842
696281007720	Cell division protein FtsA; Region: FtsA; pfam14450
696281007721	This family is most closely related to the oligosaccharide phosphorylase domain family and other unidentified sequences. Oligosaccharide phosphorylase catalyzes the breakdown of oligosaccharides into glucose-1-phosphate units. They are important...; Region: GT1_Glycogen_Phosphorylase_like; cd04299
696281007722	putative homodimer interface [polypeptide binding]; other site
696281007723	putative active site pocket [active]
696281007724	alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094
696281007725	TPR repeat; Region: TPR_11; pfam13414
696281007726	PRC-barrel domain containing protein [General function prediction only]; Region: COG3881
696281007727	Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229
696281007728	VanW like protein; Region: VanW; pfam04294
696281007729	G5 domain; Region: G5; pfam07501
696281007730	Rdx family; Region: Rdx; pfam10262
696281007731	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
696281007732	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
696281007733	dimer interface [polypeptide binding]; other site
696281007734	pyridoxal 5'-phosphate binding site [chemical binding]; other site
696281007735	catalytic residue [active]
696281007736	AAA domain; Region: AAA_32; pfam13654
696281007737	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078
696281007738	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
696281007739	Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242
696281007740	phosphoenolpyruvate synthase; Validated; Region: PRK06241
696281007741	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
696281007742	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
696281007743	S-layer homology domain; Region: SLH; pfam00395
696281007744	ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277
696281007745	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
696281007746	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
696281007747	Walker A/P-loop; other site
696281007748	ATP binding site [chemical binding]; other site
696281007749	Q-loop/lid; other site
696281007750	ABC transporter signature motif; other site
696281007751	Walker B; other site
696281007752	D-loop; other site
696281007753	H-loop/switch region; other site
696281007754	tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800
696281007755	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
696281007756	RNA polymerase sigma-70 factor, TIGR02952 family; Region: Sig70_famx2
696281007757	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
696281007758	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
696281007759	DNA binding residues [nucleotide binding]
696281007760	Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516
696281007761	Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320
696281007762	putative active site [active]
696281007763	Major Facilitator Superfamily; Region: MFS_1; pfam07690
696281007764	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
696281007765	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
696281007766	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
696281007767	active site
696281007768	Uncharacterized conserved protein [Function unknown]; Region: COG5582
696281007769	UPF0302 domain; Region: UPF0302; pfam08864
696281007770	IDEAL domain; Region: IDEAL; pfam08858
696281007771	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
696281007772	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
696281007773	dimerization interface [polypeptide binding]; other site
696281007774	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
696281007775	PAS domain; Region: PAS_9; pfam13426
696281007776	putative active site [active]
696281007777	heme pocket [chemical binding]; other site
696281007778	PAS fold; Region: PAS_4; pfam08448
696281007779	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
696281007780	putative active site [active]
696281007781	heme pocket [chemical binding]; other site
696281007782	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
696281007783	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
696281007784	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
696281007785	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
696281007786	metal binding site [ion binding]; metal-binding site
696281007787	active site
696281007788	I-site; other site
696281007789	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
696281007790	Stress responsive A/B Barrel Domain; Region: Dabb; smart00886
696281007791	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
696281007792	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
696281007793	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
696281007794	Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918
696281007795	putative active site [active]
696281007796	putative metal binding site [ion binding]; other site
696281007797	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
696281007798	binding surface
696281007799	TPR repeat; Region: TPR_11; pfam13414
696281007800	TPR motif; other site
696281007801	TPR repeat; Region: TPR_11; pfam13414
696281007802	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
696281007803	binding surface
696281007804	TPR motif; other site
696281007805	TPR repeat; Region: TPR_11; pfam13414
696281007806	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
696281007807	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
696281007808	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
696281007809	active site
696281007810	phosphorylation site [posttranslational modification]
696281007811	intermolecular recognition site; other site
696281007812	dimerization interface [polypeptide binding]; other site
696281007813	LytTr DNA-binding domain; Region: LytTR; smart00850
696281007814	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
696281007815	CoenzymeA binding site [chemical binding]; other site
696281007816	subunit interaction site [polypeptide binding]; other site
696281007817	PHB binding site; other site
696281007818	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
696281007819	Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114
696281007820	Heat shock protein 33 (Hsp33):  Cytosolic protein that acts as a molecular chaperone under oxidative conditions.  In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498
696281007821	dimerization interface [polypeptide binding]; other site
696281007822	domain crossover interface; other site
696281007823	redox-dependent activation switch; other site
696281007824	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661
696281007825	putative active site pocket [active]
696281007826	dimerization interface [polypeptide binding]; other site
696281007827	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl15777
696281007828	putative catalytic residue [active]
696281007829	butyryl-CoA:acetate CoA-transferase; Region: butyr_acet_CoA; TIGR03948
696281007830	Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550
696281007831	Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336
696281007832	This uncharacterized conserved protein belongs to a family of iron-molybdenum cluster-binding proteins that includes NifX, NifB, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of...; Region: MTH1175; cd00851
696281007833	Predicted DNA-binding proteins [General function prediction only]; Region: COG1342
696281007834	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
696281007835	Domain of unknown function (DUF4379); Region: DUF4379; pfam14311
696281007836	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
696281007837	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
696281007838	active site
696281007839	phosphorylation site [posttranslational modification]
696281007840	intermolecular recognition site; other site
696281007841	dimerization interface [polypeptide binding]; other site
696281007842	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
696281007843	DNA binding site [nucleotide binding]
696281007844	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
696281007845	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
696281007846	dimer interface [polypeptide binding]; other site
696281007847	phosphorylation site [posttranslational modification]
696281007848	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
696281007849	ATP binding site [chemical binding]; other site
696281007850	Mg2+ binding site [ion binding]; other site
696281007851	G-X-G motif; other site
696281007852	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
696281007853	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
696281007854	Walker A/P-loop; other site
696281007855	ATP binding site [chemical binding]; other site
696281007856	Q-loop/lid; other site
696281007857	ABC transporter signature motif; other site
696281007858	Walker B; other site
696281007859	D-loop; other site
696281007860	H-loop/switch region; other site
696281007861	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
696281007862	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
696281007863	FtsX-like permease family; Region: FtsX; pfam02687
696281007864	PspC domain; Region: PspC; pfam04024
696281007865	Protein of unknown function (DUF1294); Region: DUF1294; pfam06961
696281007866	Chromate transporter; Region: Chromate_transp; pfam02417
696281007867	L-asparaginase II; Region: Asparaginase_II; pfam06089
696281007868	Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486
696281007869	putative iron-only hydrogenase system regulator; Region: hyd_TM1266; TIGR03959
696281007870	Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus; Region: FrhB_FdhB_C; pfam04432
696281007871	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
696281007872	4Fe-4S dicluster domain; Region: Fer4_8; pfam13183
696281007873	Methyl-viologen-reducing hydrogenase, delta subunit; Region: FlpD; pfam02662
696281007874	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
696281007875	FAD dependent oxidoreductase; Region: DAO; pfam01266
696281007876	4Fe-4S binding domain; Region: Fer4; pfam00037
696281007877	4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484
696281007878	Heterodisulfide reductase, subunit A and related polyferredoxins [Energy production and conversion]; Region: HdrA; COG1148
696281007879	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
696281007880	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
696281007881	Heterodisulfide reductase, subunit A and related polyferredoxins [Energy production and conversion]; Region: HdrA; COG1148
696281007882	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
696281007883	glutamate synthase (NADPH), homotetrameric; Region: gltA; TIGR01316
696281007884	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
696281007885	Heterodisulfide reductase, subunit A and related polyferredoxins [Energy production and conversion]; Region: HdrA; COG1148
696281007886	Heterodisulfide reductase, subunit A and related polyferredoxins [Energy production and conversion]; Region: HdrA; COG1148
696281007887	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
696281007888	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
696281007889	Heterodisulfide reductase, subunit B [Energy production and conversion]; Region: HdrB; COG2048
696281007890	Cysteine-rich domain; Region: CCG; pfam02754
696281007891	Cysteine-rich domain; Region: CCG; pfam02754
696281007892	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
696281007893	4Fe-4S dicluster domain; Region: Fer4_17; pfam13534
696281007894	Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269
696281007895	tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696
696281007896	This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily  includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which  binds to Adenosine group.  This subfamily; Region: Alpha_ANH_like_II; cd01993
696281007897	Ligand Binding Site [chemical binding]; other site
696281007898	Protein of unknown function (DUF552); Region: DUF552; pfam04472
696281007899	NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976
696281007900	catalytic residues [active]
696281007901	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
696281007902	active site
696281007903	uracil transporter; Provisional; Region: PRK10720
696281007904	putative transposase OrfB; Reviewed; Region: PHA02517
696281007905	HTH-like domain; Region: HTH_21; pfam13276
696281007906	Integrase core domain; Region: rve; pfam00665
696281007907	Integrase core domain; Region: rve_2; pfam13333
696281007908	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
696281007909	Transposase; Region: HTH_Tnp_1; cl17663
696281007910	Helix-turn-helix domain; Region: HTH_28; pfam13518
696281007911	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
696281007912	butyryl-CoA:acetate CoA-transferase; Region: butyr_acet_CoA; TIGR03948
696281007913	Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550
696281007914	Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336
696281007915	Putative transmembrane protein (Alph_Pro_TM); Region: Alph_Pro_TM; cl09826
696281007916	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
696281007917	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
696281007918	active site
696281007919	phosphorylation site [posttranslational modification]
696281007920	intermolecular recognition site; other site
696281007921	dimerization interface [polypeptide binding]; other site
696281007922	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
696281007923	Walker A motif; other site
696281007924	ATP binding site [chemical binding]; other site
696281007925	Walker B motif; other site
696281007926	arginine finger; other site
696281007927	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
696281007928	sensory histidine kinase AtoS; Provisional; Region: PRK11360
696281007929	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
696281007930	putative active site [active]
696281007931	heme pocket [chemical binding]; other site
696281007932	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
696281007933	dimer interface [polypeptide binding]; other site
696281007934	phosphorylation site [posttranslational modification]
696281007935	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
696281007936	ATP binding site [chemical binding]; other site
696281007937	Mg2+ binding site [ion binding]; other site
696281007938	G-X-G motif; other site
696281007939	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
696281007940	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
696281007941	ABC-ATPase subunit  interface; other site
696281007942	dimer interface [polypeptide binding]; other site
696281007943	putative PBP binding regions; other site
696281007944	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
696281007945	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
696281007946	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
696281007947	metal binding site 2 [ion binding]; metal-binding site
696281007948	putative DNA binding helix; other site
696281007949	metal binding site 1 [ion binding]; metal-binding site
696281007950	dimer interface [polypeptide binding]; other site
696281007951	structural Zn2+ binding site [ion binding]; other site
696281007952	BON domain; Region: BON; pfam04972
696281007953	BON domain; Region: BON; pfam04972
696281007954	Uncharacterized conserved protein [Function unknown]; Region: COG1683
696281007955	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
696281007956	Cation efflux family; Region: Cation_efflux; pfam01545
696281007957	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657
696281007958	dinuclear metal binding motif [ion binding]; other site
696281007959	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
696281007960	Response regulator receiver domain; Region: Response_reg; pfam00072
696281007961	active site
696281007962	phosphorylation site [posttranslational modification]
696281007963	intermolecular recognition site; other site
696281007964	dimerization interface [polypeptide binding]; other site
696281007965	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
696281007966	Nitroreductase-like family 3. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_3; cd02139
696281007967	putative FMN binding site [chemical binding]; other site
696281007968	3,4-dihydroxy-2-butanone 4-phosphate synthase; Provisional; Region: ribB; PRK03353
696281007969	3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108
696281007970	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
696281007971	dimer interface [polypeptide binding]; other site
696281007972	putative CheW interface [polypeptide binding]; other site
696281007973	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
696281007974	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
696281007975	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
696281007976	activation loop (A-loop); other site
696281007977	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
696281007978	Transposase; Region: DEDD_Tnp_IS110; pfam01548
696281007979	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
696281007980	spermidine synthase; Provisional; Region: PRK00811
696281007981	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
696281007982	S-adenosylmethionine binding site [chemical binding]; other site
696281007983	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
696281007984	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
696281007985	Walker A/P-loop; other site
696281007986	ATP binding site [chemical binding]; other site
696281007987	Q-loop/lid; other site
696281007988	ABC transporter signature motif; other site
696281007989	Walker B; other site
696281007990	D-loop; other site
696281007991	H-loop/switch region; other site
696281007992	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
696281007993	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
696281007994	Walker A/P-loop; other site
696281007995	ATP binding site [chemical binding]; other site
696281007996	Q-loop/lid; other site
696281007997	ABC transporter signature motif; other site
696281007998	Walker B; other site
696281007999	D-loop; other site
696281008000	H-loop/switch region; other site
696281008001	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
696281008002	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
696281008003	TM-ABC transporter signature motif; other site
696281008004	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
696281008005	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
696281008006	TM-ABC transporter signature motif; other site
696281008007	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
696281008008	Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_12; cd06347
696281008009	putative ligand binding site [chemical binding]; other site
696281008010	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315
696281008011	Uncharacterized protein conserved in bacteria (DUF2087); Region: DUF2087; pfam09860
696281008012	Uncharacterized protein conserved in bacteria (DUF2087); Region: DUF2087; pfam09860
696281008013	GIY-YIG domain of LuxR and ArsR family transcriptional regulators, and uncharacterized hypothetical proteins found in bacteria; Region: GIY-YIG_LuxR_like; cd10451
696281008014	GIY-YIG motif/motif A; other site
696281008015	Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655
696281008016	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
696281008017	Uncharacterized conserved protein [Function unknown]; Region: COG1739
696281008018	Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205
696281008019	Domain of unknown function (DUF1949); Region: DUF1949; pfam09186
696281008020	2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982
696281008021	ABC1 family; Region: ABC1; pfam03109
696281008022	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
696281008023	active site
696281008024	ATP binding site [chemical binding]; other site
696281008025	Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109
696281008026	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
696281008027	DNA binding residues [nucleotide binding]
696281008028	putative dimer interface [polypeptide binding]; other site
696281008029	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
696281008030	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
696281008031	ABC transporter; Region: ABC_tran_2; pfam12848
696281008032	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
696281008033	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
696281008034	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246
696281008035	putative dimer interface [polypeptide binding]; other site
696281008036	Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281
696281008037	homodimer interaction site [polypeptide binding]; other site
696281008038	cofactor binding site; other site
696281008039	Response regulator containing CheY-like receiver and SARP domains [Signal transduction mechanisms]; Region: COG3947
696281008040	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
696281008041	active site
696281008042	phosphorylation site [posttranslational modification]
696281008043	intermolecular recognition site; other site
696281008044	dimerization interface [polypeptide binding]; other site
696281008045	Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862
696281008046	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
696281008047	7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695
696281008048	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
696281008049	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
696281008050	dimer interface [polypeptide binding]; other site
696281008051	phosphorylation site [posttranslational modification]
696281008052	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
696281008053	ATP binding site [chemical binding]; other site
696281008054	Mg2+ binding site [ion binding]; other site
696281008055	G-X-G motif; other site
696281008056	Response regulator receiver domain; Region: Response_reg; pfam00072
696281008057	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
696281008058	active site
696281008059	phosphorylation site [posttranslational modification]
696281008060	intermolecular recognition site; other site
696281008061	dimerization interface [polypeptide binding]; other site
696281008062	Histidine kinase; Region: His_kinase; pfam06580
696281008063	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
696281008064	ATP binding site [chemical binding]; other site
696281008065	Mg2+ binding site [ion binding]; other site
696281008066	G-X-G motif; other site
696281008067	The GLUG motif; Region: Glug; pfam07581
696281008068	Immunoglobulin I-set domain; Region: I-set; pfam07679
696281008069	Immunoglobulin; Region: IG; smart00409
696281008070	Immunoglobulin I-set domain; Region: I-set; pfam07679
696281008071	Immunoglobulin domain; Region: Ig; cd00096
696281008072	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
696281008073	Interdomain contacts; other site
696281008074	Cytokine receptor motif; other site
696281008075	S-layer homology domain; Region: SLH; pfam00395
696281008076	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
696281008077	non-specific DNA binding site [nucleotide binding]; other site
696281008078	salt bridge; other site
696281008079	sequence-specific DNA binding site [nucleotide binding]; other site
696281008080	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
696281008081	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
696281008082	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708
696281008083	Putative zinc ribbon domain; Region: Zn_ribbon_2; pfam12674
696281008084	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
696281008085	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
696281008086	Uncharacterized family 1; belongs to a superfamily containing the transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this family was previously known as part of DUF156; Region: CsoR-like_DUF156_1; cd10158
696281008087	putative homodimer interface [polypeptide binding]; other site
696281008088	putative homotetramer interface [polypeptide binding]; other site
696281008089	putative metal binding site [ion binding]; other site
696281008090	putative homodimer-homodimer interface [polypeptide binding]; other site
696281008091	putative allosteric switch controlling residues; other site
696281008092	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
696281008093	EamA-like transporter family; Region: EamA; pfam00892
696281008094	Transcriptional regulators [Transcription]; Region: FadR; COG2186
696281008095	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
696281008096	DNA-binding site [nucleotide binding]; DNA binding site
696281008097	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
696281008098	dihydroxy-acid dehydratase; Provisional; Region: PRK00911
696281008099	Protein of unknown function (DUF2680); Region: DUF2680; pfam10925
696281008100	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
696281008101	MarR family; Region: MarR_2; pfam12802
696281008102	Holin family; Region: Phage_holin_4; pfam05105
696281008103	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
696281008104	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
696281008105	non-specific DNA binding site [nucleotide binding]; other site
696281008106	salt bridge; other site
696281008107	sequence-specific DNA binding site [nucleotide binding]; other site
696281008108	Protein of unknown function (DUF2762); Region: DUF2762; pfam10960
696281008109	phosphodiesterase; Provisional; Region: PRK12704
696281008110	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
696281008111	DNA-binding interface [nucleotide binding]; DNA binding site
696281008112	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
696281008113	HTH-like domain; Region: HTH_21; pfam13276
696281008114	Integrase core domain; Region: rve; pfam00665
696281008115	Integrase core domain; Region: rve_3; pfam13683
696281008116	Transposase; Region: DEDD_Tnp_IS110; pfam01548
696281008117	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
696281008118	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
696281008119	probable DNA metabolism protein; Region: SAM_7_link_chp; TIGR03915
696281008120	putative DNA modification/repair radical SAM protein; Region: rSAM_link_UDG; TIGR03916
696281008121	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
696281008122	FeS/SAM binding site; other site
696281008123	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
696281008124	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day.  Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803
696281008125	active site
696281008126	FMN binding site [chemical binding]; other site
696281008127	substrate binding site [chemical binding]; other site
696281008128	putative catalytic residue [active]
696281008129	Predicted transcriptional regulators [Transcription]; Region: COG1733
696281008130	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
696281008131	asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932
696281008132	AsnRS_cyto_like_N: N-terminal, anticodon recognition domain of the type found in human and Saccharomyces cerevisiae cytoplasmic asparaginyl-tRNA synthetase (AsnRS), in Brugia malayai AsnRs and, in various putative bacterial AsnRSs.  This domain is a...; Region: AsnRS_cyto_like_N; cd04323
696281008133	putative dimer interface [polypeptide binding]; other site
696281008134	putative anticodon binding site; other site
696281008135	Asx tRNA synthetase (AspRS/AsnRS) class II core domain.  Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776
696281008136	homodimer interface [polypeptide binding]; other site
696281008137	motif 1; other site
696281008138	motif 2; other site
696281008139	active site
696281008140	motif 3; other site
696281008141	BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271
696281008142	benzoyl-CoA reductase, subunit C; Region: benz_CoA_red_C; TIGR02263
696281008143	2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050
696281008144	Uncharacterized Fe-S center protein [General function prediction only]; Region: COG2768
696281008145	Uncharacterized conserved protein [Function unknown]; Region: COG2006
696281008146	4Fe-4S binding domain; Region: Fer4; pfam00037
696281008147	Protein of unknown function (DUF503); Region: DUF503; pfam04456
696281008148	Peptidase family M48; Region: Peptidase_M48; cl12018
696281008149	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
696281008150	CoenzymeA binding site [chemical binding]; other site
696281008151	subunit interaction site [polypeptide binding]; other site
696281008152	PHB binding site; other site
696281008153	H+ Antiporter protein; Region: 2A0121; TIGR00900
696281008154	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
696281008155	putative substrate translocation pore; other site
696281008156	EDD domain protein, DegV family; Region: DegV; TIGR00762
696281008157	Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645
696281008158	DAK2 domain fusion protein YloV; Region: YloV; TIGR03599
696281008159	DAK2 domain; Region: Dak2; pfam02734
696281008160	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
696281008161	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
696281008162	catalytic residues [active]
696281008163	Protein of unknown function (DUF2089); Region: DUF2089; pfam09862
696281008164	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
696281008165	Protein of unknown function (DUF1212); Region: DUF1212; pfam06738
696281008166	Membrane protein of unknown function; Region: DUF360; pfam04020
696281008167	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
696281008168	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
696281008169	non-specific DNA binding site [nucleotide binding]; other site
696281008170	salt bridge; other site
696281008171	sequence-specific DNA binding site [nucleotide binding]; other site
696281008172	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4877
696281008173	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
696281008174	A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  Many of these band 7 domain-containing proteins are lipid raft-associated.  Individual...; Region: Band_7_2; cd03402
696281008175	S-layer homology domain; Region: SLH; pfam00395
696281008176	S-layer homology domain; Region: SLH; pfam00395
696281008177	PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172
696281008178	Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644
696281008179	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
696281008180	Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841
696281008181	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
696281008182	active site
696281008183	metal binding site [ion binding]; metal-binding site
696281008184	homotetramer interface [polypeptide binding]; other site
696281008185	GTP-binding protein HflX; Region: GTP_HflX; TIGR03156
696281008186	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
696281008187	HflX GTPase family; Region: HflX; cd01878
696281008188	G1 box; other site
696281008189	GTP/Mg2+ binding site [chemical binding]; other site
696281008190	Switch I region; other site
696281008191	G2 box; other site
696281008192	G3 box; other site
696281008193	Switch II region; other site
696281008194	G4 box; other site
696281008195	G5 box; other site
696281008196	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
696281008197	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
696281008198	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
696281008199	Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809
696281008200	active site
696281008201	substrate binding site [chemical binding]; other site
696281008202	FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070
696281008203	FMN binding site [chemical binding]; other site
696281008204	putative catalytic residues [active]
696281008205	FOG: CBS domain [General function prediction only]; Region: COG0517
696281008206	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in  the acetoin utilization proteins in bacteria. Acetoin is a product of fermentative metabolism in many prokaryotic and eukaryotic microorganisms.  They produce...; Region: CBS_pair_ACT_assoc; cd04584
696281008207	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
696281008208	Rubredoxin_like; nonheme iron binding domain containing a [Fe(SCys)4] center. The family includes rubredoxins, a small electron transfer protein, and a slightly smaller modular rubredoxin domain present in rubrerythrin and nigerythrin and detected either...; Region: rubredoxin_like; cl00202
696281008209	iron binding site [ion binding]; other site
696281008210	Flavin reductase like domain; Region: Flavin_Reduct; pfam01613
696281008211	Methyltransferase domain; Region: Methyltransf_23; pfam13489
696281008212	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
696281008213	S-adenosylmethionine binding site [chemical binding]; other site
696281008214	putative menaquinone biosynthesis protein, SCO4494 family; Region: mena_SCO4494; TIGR03700
696281008215	Serine dehydratase alpha chain; Region: SDH_alpha; cl12120
696281008216	L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760
696281008217	L-serine dehydratase, iron-sulfur-dependent, beta subunit; Region: sda_beta; TIGR00719
696281008218	Serine dehydratase beta chain; Region: SDH_beta; pfam03315
696281008219	C-terminal ACT domain of the L-serine dehydratase (LSD), iron-sulfur-dependent, beta subunit; Region: ACT_LSD; cd04903
696281008220	putative L-serine binding site [chemical binding]; other site
696281008221	MarR family; Region: MarR; pfam01047
696281008222	Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541
696281008223	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
696281008224	acyl-activating enzyme (AAE) consensus motif; other site
696281008225	AMP binding site [chemical binding]; other site
696281008226	active site
696281008227	CoA binding site [chemical binding]; other site
696281008228	indolepyruvate oxidoreductase subunit beta; Reviewed; Region: PRK06853
696281008229	2-oxoglutarate ferredoxin oxidoreductase subunit gamma; Validated; Region: PRK08537
696281008230	indolepyruvate ferredoxin oxidoreductase, alpha subunit; Region: IOR_alpha; TIGR03336
696281008231	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
696281008232	dimer interface [polypeptide binding]; other site
696281008233	PYR/PP interface [polypeptide binding]; other site
696281008234	TPP binding site [chemical binding]; other site
696281008235	substrate binding site [chemical binding]; other site
696281008236	Thiamine pyrophosphate (TPP) family, IOR-alpha subfamily, TPP-binding module; composed of proteins similar to indolepyruvate ferredoxin oxidoreductase (IOR) alpha subunit. IOR catalyzes the oxidative decarboxylation of arylpyruvates, such as...; Region: TPP_IOR_alpha; cd02008
696281008237	TPP-binding site; other site
696281008238	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
696281008239	ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619
696281008240	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
696281008241	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
696281008242	Walker A/P-loop; other site
696281008243	ATP binding site [chemical binding]; other site
696281008244	Q-loop/lid; other site
696281008245	ABC transporter signature motif; other site
696281008246	Walker B; other site
696281008247	D-loop; other site
696281008248	H-loop/switch region; other site
696281008249	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
696281008250	Walker A/P-loop; other site
696281008251	ATP binding site [chemical binding]; other site
696281008252	ABC transporter; Region: ABC_tran; pfam00005
696281008253	Q-loop/lid; other site
696281008254	ABC transporter signature motif; other site
696281008255	Walker B; other site
696281008256	D-loop; other site
696281008257	H-loop/switch region; other site
696281008258	SirA_like_N, a protein of unknown function with an N-terminal SirA-like domain.  The SirA, YedF, YeeD protein family is present in bacteria as well as archaea. SirA (also known as UvrY,  and YhhP) belongs to a family of a two-component response...; Region: SirA_like_N; cd03421
696281008259	selenium metabolism protein YedF; Region: selenium_YedF; TIGR03527
696281008260	CPxP  motif; other site
696281008261	selenophosphate synthetase; Provisional; Region: PRK00943
696281008262	Selenophosphate synthetase  (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195
696281008263	dimerization interface [polypeptide binding]; other site
696281008264	putative ATP binding site [chemical binding]; other site
696281008265	glutamate racemase; Provisional; Region: PRK00865
696281008266	Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cl17698
696281008267	Asp-box motif; other site
696281008268	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
696281008269	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
696281008270	active site
696281008271	phosphorylation site [posttranslational modification]
696281008272	intermolecular recognition site; other site
696281008273	dimerization interface [polypeptide binding]; other site
696281008274	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355
696281008275	DNA binding site [nucleotide binding]
696281008276	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
696281008277	dimer interface [polypeptide binding]; other site
696281008278	phosphorylation site [posttranslational modification]
696281008279	Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172
696281008280	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
696281008281	ATP binding site [chemical binding]; other site
696281008282	Mg2+ binding site [ion binding]; other site
696281008283	G-X-G motif; other site
696281008284	Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681
696281008285	Post-segregation antitoxin CcdA; Region: CcdA; cl02188
696281008286	Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605
696281008287	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
696281008288	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
696281008289	Acetyltransferase (GNAT) domain; Region: Acetyltransf_9; pfam13527
696281008290	Sterol carrier protein domain; Region: SCP2_2; pfam13530
696281008291	PIN domain of the Pyrobaculum aerophilum Pae0151 and Pae2754 proteins and homologs; Region: PIN_Pae0151; cd09873
696281008292	putative active site [active]
696281008293	homotetrameric interface [polypeptide binding]; other site
696281008294	metal binding site [ion binding]; metal-binding site
696281008295	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604
696281008296	Fic family protein [Function unknown]; Region: COG3177
696281008297	Fic/DOC family; Region: Fic; pfam02661
696281008298	site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236
696281008299	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
696281008300	active site
696281008301	DNA binding site [nucleotide binding]
696281008302	Int/Topo IB signature motif; other site
696281008303	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
696281008304	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
696281008305	Winged helix DNA-binding domain; Region: HTH_27; pfam13463
696281008306	Protein of unknown function (DUF2807); Region: DUF2807; pfam10988
696281008307	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
696281008308	ATP binding site [chemical binding]; other site
696281008309	Mg2+ binding site [ion binding]; other site
696281008310	G-X-G motif; other site
696281008311	Accessory gene regulator B; Region: AgrB; pfam04647
696281008312	cyclic lactone autoinducer peptide; Region: quorum_AgrD; TIGR04223
696281008313	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
696281008314	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
696281008315	active site
696281008316	phosphorylation site [posttranslational modification]
696281008317	intermolecular recognition site; other site
696281008318	dimerization interface [polypeptide binding]; other site
696281008319	LytTr DNA-binding domain; Region: LytTR; smart00850
696281008320	Predicted membrane protein [Function unknown]; Region: COG2510
696281008321	Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982
696281008322	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
696281008323	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
696281008324	catalytic residue [active]
696281008325	Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711
696281008326	VanW like protein; Region: VanW; pfam04294
696281008327	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
696281008328	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
696281008329	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
696281008330	ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254
696281008331	Walker A/P-loop; other site
696281008332	ATP binding site [chemical binding]; other site
696281008333	Q-loop/lid; other site
696281008334	ABC transporter signature motif; other site
696281008335	Walker B; other site
696281008336	D-loop; other site
696281008337	H-loop/switch region; other site
696281008338	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
696281008339	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
696281008340	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
696281008341	Walker A/P-loop; other site
696281008342	ATP binding site [chemical binding]; other site
696281008343	Q-loop/lid; other site
696281008344	ABC transporter signature motif; other site
696281008345	Walker B; other site
696281008346	D-loop; other site
696281008347	H-loop/switch region; other site
696281008348	Predicted transcriptional regulators [Transcription]; Region: COG1725
696281008349	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
696281008350	DNA-binding site [nucleotide binding]; DNA binding site
696281008351	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
696281008352	gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740
696281008353	Walker A/P-loop; other site
696281008354	ATP binding site [chemical binding]; other site
696281008355	Q-loop/lid; other site
696281008356	ABC transporter signature motif; other site
696281008357	Walker B; other site
696281008358	D-loop; other site
696281008359	H-loop/switch region; other site
696281008360	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
696281008361	Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113
696281008362	Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686
696281008363	Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305
696281008364	hexamer interface [polypeptide binding]; other site
696281008365	ligand binding site [chemical binding]; other site
696281008366	putative active site [active]
696281008367	NAD(P) binding site [chemical binding]; other site
696281008368	diaminopimelate decarboxylase; Region: lysA; TIGR01048
696281008369	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
696281008370	active site
696281008371	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
696281008372	substrate binding site [chemical binding]; other site
696281008373	catalytic residues [active]
696281008374	dimer interface [polypeptide binding]; other site
696281008375	Sugar-specific transcriptional regulator TrmB; Region: TrmB; pfam01978
696281008376	Predicted transcriptional regulators [Transcription]; Region: COG1378
696281008377	Middle phospholipase D-like domain of the transcriptional regulator TrmB and similar proteins; Region: PLDc_like_TrmB_middle; cd09124
696281008378	C-terminal domain interface [polypeptide binding]; other site
696281008379	sugar binding site [chemical binding]; other site
696281008380	4Fe-4S binding domain; Region: Fer4; pfam00037
696281008381	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
696281008382	putative sporulation protein YtaF; Region: spore_YtaF; TIGR02840
696281008383	Domain of unknown function DUF; Region: DUF204; pfam02659
696281008384	anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK07111
696281008385	Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670
696281008386	BAX inhibitor (BI)-1/YccA-like protein family; Region: BI-1-like; cl00473
696281008387	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
696281008388	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
696281008389	Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086
696281008390	putative catalytic site [active]
696281008391	putative phosphate binding site [ion binding]; other site
696281008392	active site
696281008393	metal binding site A [ion binding]; metal-binding site
696281008394	DNA binding site [nucleotide binding]
696281008395	putative AP binding site [nucleotide binding]; other site
696281008396	putative metal binding site B [ion binding]; other site
696281008397	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215
696281008398	Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125
696281008399	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
696281008400	TMP-binding site; other site
696281008401	ATP-binding site [chemical binding]; other site
696281008402	Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125
696281008403	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
696281008404	TMP-binding site; other site
696281008405	ATP-binding site [chemical binding]; other site
696281008406	Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248
696281008407	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
696281008408	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
696281008409	Zn2+ binding site [ion binding]; other site
696281008410	Mg2+ binding site [ion binding]; other site
696281008411	Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229
696281008412	VanW like protein; Region: VanW; pfam04294
696281008413	G5 domain; Region: G5; pfam07501
696281008414	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
696281008415	CHASE3 domain; Region: CHASE3; cl05000
696281008416	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
696281008417	dimerization interface [polypeptide binding]; other site
696281008418	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
696281008419	dimer interface [polypeptide binding]; other site
696281008420	Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015
696281008421	putative CheW interface [polypeptide binding]; other site
696281008422	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
696281008423	dimer interface [polypeptide binding]; other site
696281008424	putative CheW interface [polypeptide binding]; other site
696281008425	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4365
696281008426	bacillithiol biosynthesis cysteine-adding enzyme BshC; Region: thiol_BshC; TIGR03998
696281008427	voltage-gated potassium channel; Provisional; Region: PRK10537
696281008428	Zinc ribbon domain; Region: CxxC_CxxC_SSSS; pfam09723
696281008429	Copper chaperone [Inorganic ion transport and metabolism]; Region: CopZ; COG2608
696281008430	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
696281008431	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
696281008432	Coenzyme A binding pocket [chemical binding]; other site
696281008433	gamma-glutamyl kinase; Provisional; Region: PRK05429
696281008434	AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242
696281008435	nucleotide binding site [chemical binding]; other site
696281008436	homotetrameric interface [polypeptide binding]; other site
696281008437	putative phosphate binding site [ion binding]; other site
696281008438	putative allosteric binding site; other site
696281008439	Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079
696281008440	gamma-glutamyl phosphate reductase; Region: proA; TIGR00407
696281008441	putative catalytic cysteine [active]
696281008442	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232
696281008443	pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880
696281008444	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
696281008445	Ligand Binding Site [chemical binding]; other site
696281008446	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
696281008447	Ligand Binding Site [chemical binding]; other site
696281008448	copper transport repressor, CopY/TcrY family; Region: CopY_TcrY; TIGR02698
696281008449	Penicillinase repressor; Region: Pencillinase_R; pfam03965
696281008450	BlaR1 peptidase M56; Region: Peptidase_M56; pfam05569
696281008451	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
696281008452	MarR family; Region: MarR; pfam01047
696281008453	MarR family; Region: MarR_2; cl17246
696281008454	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
696281008455	Major Facilitator Superfamily; Region: MFS_1; pfam07690
696281008456	putative substrate translocation pore; other site
696281008457	Putative exporter of polyketide antibiotics [Cell envelope biogenesis, outer membrane]; Region: TnrB3; COG3559
696281008458	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
696281008459	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
696281008460	Walker A/P-loop; other site
696281008461	ATP binding site [chemical binding]; other site
696281008462	Q-loop/lid; other site
696281008463	ABC transporter signature motif; other site
696281008464	Walker B; other site
696281008465	D-loop; other site
696281008466	H-loop/switch region; other site
696281008467	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
696281008468	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
696281008469	phosphoenolpyruvate synthase; Validated; Region: PRK06241
696281008470	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
696281008471	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
696281008472	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
696281008473	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
696281008474	aspartate kinase; Reviewed; Region: PRK06635
696281008475	AAK_AK-DapG-like: Amino Acid Kinase Superfamily (AAK), AK-DapG-like; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the diaminopimelate-sensitive aspartokinase isoenzyme AKI (DapG), a monofunctional enzymes found in Bacilli; Region: AAK_AK-DapG-like; cd04246
696281008476	putative catalytic residues [active]
696281008477	putative nucleotide binding site [chemical binding]; other site
696281008478	putative aspartate binding site [chemical binding]; other site
696281008479	ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913
696281008480	putative allosteric regulatory site; other site
696281008481	ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936
696281008482	putative allosteric regulatory residue; other site
696281008483	homoserine kinase; Provisional; Region: PRK01212
696281008484	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
696281008485	homoserine dehydrogenase; Provisional; Region: PRK06349
696281008486	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
696281008487	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
696281008488	ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881
696281008489	hypothetical protein; Provisional; Region: PRK04435
696281008490	C-terminal ACT domain of a small (; 147 a.a.) putative phenylalanine biosynthetic pathway protein described in Bacillus subtilis (BS) PheB (PheB-BS) and related domains; Region: ACT_PheB-BS; cd04888
696281008491	Stage IV sporulation protein A (spore_IV_A); Region: Spore_IV_A; pfam09547
696281008492	stage IV sporulation protein A; Region: spore_IV_A; TIGR02836
696281008493	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094
696281008494	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
696281008495	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
696281008496	Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; cl00410
696281008497	GTP-binding protein Der; Reviewed; Region: PRK00093
696281008498	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
696281008499	G1 box; other site
696281008500	GTP/Mg2+ binding site [chemical binding]; other site
696281008501	Switch I region; other site
696281008502	G2 box; other site
696281008503	Switch II region; other site
696281008504	G3 box; other site
696281008505	G4 box; other site
696281008506	G5 box; other site
696281008507	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
696281008508	G1 box; other site
696281008509	GTP/Mg2+ binding site [chemical binding]; other site
696281008510	Switch I region; other site
696281008511	G2 box; other site
696281008512	G3 box; other site
696281008513	Switch II region; other site
696281008514	G4 box; other site
696281008515	G5 box; other site
696281008516	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
696281008517	putative FeS-containing Cyanobacterial-specific oxidoreductase; Region: cyano_FeS_chp; TIGR03279
696281008518	Protein of unknown function (DUF512); Region: DUF512; pfam04459
696281008519	YIEGIA protein; Region: YIEGIA; pfam14045
696281008520	Stage II sporulation protein P (SpoIIP); Region: SpoIIP; pfam07454
696281008521	stage II sporulation protein P; Region: spore_II_P; TIGR02867
696281008522	Protein of unknown function (DUF1614); Region: DUF1614; pfam07758
696281008523	Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075
696281008524	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
696281008525	RNA binding site [nucleotide binding]; other site
696281008526	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
696281008527	YD repeat (two copies); Region: YD_repeat_2x; TIGR01643
696281008528	RHS Repeat; Region: RHS_repeat; pfam05593
696281008529	YD repeat (two copies); Region: YD_repeat_2x; TIGR01643
696281008530	RHS protein; Region: RHS; pfam03527
696281008531	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
696281008532	4-hydroxy-3-methylbut-2-enyl diphosphate reductase/S1 RNA-binding domain protein; Reviewed; Region: PRK00087
696281008533	4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761
696281008534	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
696281008535	RNA binding site [nucleotide binding]; other site
696281008536	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
696281008537	RNA binding site [nucleotide binding]; other site
696281008538	S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688
696281008539	RNA binding site [nucleotide binding]; other site
696281008540	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
696281008541	RNA binding site [nucleotide binding]; other site
696281008542	domain interface; other site
696281008543	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
696281008544	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
696281008545	putative acyl-acceptor binding pocket; other site
696281008546	cytidylate kinase; Provisional; Region: cmk; PRK00023
696281008547	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
696281008548	CMP-binding site; other site
696281008549	The sites determining sugar specificity; other site
696281008550	3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427
696281008551	EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556
696281008552	hinge; other site
696281008553	active site
696281008554	Prephenate dehydrogenase [Amino acid transport and metabolism]; Region: TyrA; COG0287
696281008555	prephenate dehydrogenase; Validated; Region: PRK08507
696281008556	3-deoxy-7-phosphoheptulonate synthase; Reviewed; Region: PRK08673
696281008557	phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361
696281008558	aspartate aminotransferase; Provisional; Region: PRK06836
696281008559	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
696281008560	pyridoxal 5'-phosphate binding site [chemical binding]; other site
696281008561	homodimer interface [polypeptide binding]; other site
696281008562	catalytic residue [active]
696281008563	Chorismate mutase (AroH) is one of at least five chorismate-utilizing enzymes present in microorganisms that catalyze the rearrangement of chorismate to prephenic acid, the first committed step in the biosynthesis of aromatic amino acids. In prokaryotes; Region: AroH; cd02185
696281008564	homotrimer interaction site [polypeptide binding]; other site
696281008565	active site
696281008566	Histidine Utilizing Protein, the hut operon positive regulatory protein; Region: HutP; cd11640
696281008567	hexamer interface [polypeptide binding]; other site
696281008568	RNA binding site [nucleotide binding]; other site
696281008569	Histidine-zinc binding site [chemical binding]; other site
696281008570	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
696281008571	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
696281008572	RNA binding surface [nucleotide binding]; other site
696281008573	Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870
696281008574	active site
696281008575	Uncharacterized membrane protein [Function unknown]; Region: SpmB; COG0700
696281008576	Uncharacterized membrane protein, required for spore maturation in B.subtilis. [General function prediction only]; Region: SpmA; COG2715
696281008577	nitrogen regulation protein NR(II); Provisional; Region: glnL; PRK11073
696281008578	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
696281008579	putative active site [active]
696281008580	heme pocket [chemical binding]; other site
696281008581	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
696281008582	dimer interface [polypeptide binding]; other site
696281008583	phosphorylation site [posttranslational modification]
696281008584	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
696281008585	ATP binding site [chemical binding]; other site
696281008586	G-X-G motif; other site
696281008587	Sporulation protein YtfJ (Spore_YtfJ); Region: Spore_YtfJ; cl01596
696281008588	Protein of unknown function (DUF2953); Region: DUF2953; pfam11167
696281008589	Immunoglobulin-like domain of bacterial spore germination; Region: Gmad2; pfam10648
696281008590	Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079
696281008591	segregation and condensation protein A; Reviewed; Region: scpA; PRK00104
696281008592	tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282
696281008593	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
696281008594	active site
696281008595	HIGH motif; other site
696281008596	dimer interface [polypeptide binding]; other site
696281008597	KMSKS motif; other site
696281008598	Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158
696281008599	Peptidase family M50; Region: Peptidase_M50; pfam02163
696281008600	active site
696281008601	putative substrate binding region [chemical binding]; other site
696281008602	Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618
696281008603	DHH family; Region: DHH; pfam01368
696281008604	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
696281008605	FOG: CBS domain [General function prediction only]; Region: COG0517
696281008606	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with an upstream DHH domain which performs a phosphoesterase function and a downstream polyA polymerase domain. CBS is a small domain originally...; Region: CBS_pair_DHH_polyA_Pol_assoc; cd04595
696281008607	tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617
696281008608	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
696281008609	active site
696281008610	NTP binding site [chemical binding]; other site
696281008611	metal binding triad [ion binding]; metal-binding site
696281008612	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
696281008613	diaminopimelate decarboxylase; Region: lysA; TIGR01048
696281008614	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
696281008615	active site
696281008616	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
696281008617	substrate binding site [chemical binding]; other site
696281008618	catalytic residues [active]
696281008619	dimer interface [polypeptide binding]; other site
696281008620	Transcriptional accessory protein [Transcription]; Region: Tex; COG2183
696281008621	Tex-like protein N-terminal domain; Region: Tex_N; pfam09371
696281008622	Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732
696281008623	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
696281008624	RNA binding site [nucleotide binding]; other site
696281008625	Helix-turn-helix domain; Region: HTH_28; pfam13518
696281008626	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
696281008627	Helix-turn-helix domain; Region: HTH_28; pfam13518
696281008628	putative transposase OrfB; Reviewed; Region: PHA02517
696281008629	HTH-like domain; Region: HTH_21; pfam13276
696281008630	Integrase core domain; Region: rve; pfam00665
696281008631	Integrase core domain; Region: rve_2; pfam13333
696281008632	Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) [Lipid metabolism]; Region: COG1924
696281008633	BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271
696281008634	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3581
696281008635	CoA enzyme activase uncharacterized domain (DUF2229); Region: DUF2229; pfam09989
696281008636	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3581
696281008637	Protein of unknown function (DUF1657); Region: DUF1657; pfam07870
696281008638	NADP(H)-dependent alcohol dehydrogenases; Region: NADP_ADH; cd08285
696281008639	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
696281008640	tetramer interface [polypeptide binding]; other site
696281008641	catalytic Zn binding site [ion binding]; other site
696281008642	NADP binding site [chemical binding]; other site
696281008643	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
696281008644	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
696281008645	active site
696281008646	phosphorylation site [posttranslational modification]
696281008647	intermolecular recognition site; other site
696281008648	dimerization interface [polypeptide binding]; other site
696281008649	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
696281008650	DNA binding residues [nucleotide binding]
696281008651	dimerization interface [polypeptide binding]; other site
696281008652	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
696281008653	GAF domain; Region: GAF_3; pfam13492
696281008654	GAF domain; Region: GAF_2; pfam13185
696281008655	GAF domain; Region: GAF; cl17456
696281008656	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
696281008657	Histidine kinase; Region: HisKA_3; pfam07730
696281008658	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
696281008659	ATP binding site [chemical binding]; other site
696281008660	Mg2+ binding site [ion binding]; other site
696281008661	G-X-G motif; other site
696281008662	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
696281008663	Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872
696281008664	active site
696281008665	NAD binding site [chemical binding]; other site
696281008666	metal binding site [ion binding]; metal-binding site
696281008667	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
696281008668	CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725
696281008669	CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-B; cd09722
696281008670	Domain of unknown function DUF83; Region: Cas_Cas4; pfam01930
696281008671	CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641
696281008672	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
696281008673	CRISPR-associated protein Cas5, subtype I-B/HMARI; Region: cas_Cas5h; TIGR02592
696281008674	CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I; cl12040
696281008675	Family of unknown function (DUF694); Region: DUF694; pfam05107
696281008676	CRISPR/Cas system-associated protein Cas8b; Region: Cas8b_I-B; cl09718
696281008677	CRISPR associated protein Cas6; Region: Cas_Cas6; pfam01881
696281008678	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
696281008679	molybdopterin cofactor binding site; other site
696281008680	Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929
696281008681	molybdopterin cofactor binding site; other site
696281008682	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
696281008683	catalytic loop [active]
696281008684	iron binding site [ion binding]; other site
696281008685	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588
696281008686	4Fe-4S dicluster domain; Region: Fer4_10; pfam13237
696281008687	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
696281008688	Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980
696281008689	dimer interface [polypeptide binding]; other site
696281008690	[2Fe-2S] cluster binding site [ion binding]; other site
696281008691	NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894
696281008692	SLBB domain; Region: SLBB; pfam10531
696281008693	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928
696281008694	4Fe-4S binding domain; Region: Fer4; pfam00037
696281008695	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
696281008696	Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257
696281008697	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064
696281008698	putative dimer interface [polypeptide binding]; other site
696281008699	[2Fe-2S] cluster binding site [ion binding]; other site
696281008700	Sec-independent protein translocase protein (TatC); Region: TatC; pfam00902
696281008701	Protein involved in formate dehydrogenase formation; Region: FdhE; pfam04216
696281008702	formate dehydrogenase accessory protein FdhE; Region: FdhE; TIGR01562
696281008703	Polysulphide reductase [Energy production and conversion]; Region: COG5557; cl17901
696281008704	Polysulphide reductase, NrfD; Region: NrfD; pfam03916
696281008705	4Fe-4S dicluster domain; Region: Fer4_11; pfam13247
696281008706	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
696281008707	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
696281008708	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
696281008709	Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792
696281008710	molybdopterin cofactor binding site; other site
696281008711	TAT (twin-arginine translocation) pathway signal sequence; Region: TAT_signal; pfam10518
696281008712	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
696281008713	MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503
696281008714	molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317
696281008715	GTP binding site; other site
696281008716	Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323
696281008717	Stage V sporulation protein AE1; Region: SpoVAE; pfam14097
696281008718	stage V sporulation protein AE; Region: spore_V_AE; TIGR02839
696281008719	stage V sporulation protein AD; Validated; Region: PRK08304
696281008720	stage V sporulation protein AD; Provisional; Region: PRK12404
696281008721	SpoVA protein; Region: SpoVA; cl04298
696281008722	sporulation sigma factor SigF; Validated; Region: PRK05572
696281008723	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
696281008724	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
696281008725	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
696281008726	DNA binding residues [nucleotide binding]
696281008727	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
696281008728	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
696281008729	ATP binding site [chemical binding]; other site
696281008730	Mg2+ binding site [ion binding]; other site
696281008731	G-X-G motif; other site
696281008732	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
696281008733	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
696281008734	anti sigma factor interaction site; other site
696281008735	regulatory phosphorylation site [posttranslational modification]; other site
696281008736	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686
696281008737	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
696281008738	Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936
696281008739	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
696281008740	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
696281008741	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
696281008742	putative Zn2+ binding site [ion binding]; other site
696281008743	putative DNA binding site [nucleotide binding]; other site
696281008744	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
696281008745	Major Facilitator Superfamily; Region: MFS_1; pfam07690
696281008746	putative substrate translocation pore; other site
696281008747	Predicted transcriptional regulators [Transcription]; Region: COG1725
696281008748	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
696281008749	DNA-binding site [nucleotide binding]; DNA binding site
696281008750	Predicted membrane protein [General function prediction only]; Region: COG4194
696281008751	pyrimidine-nucleoside phosphorylase; Reviewed; Region: PRK06078
696281008752	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
696281008753	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
696281008754	Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941
696281008755	phosphopentomutase; Provisional; Region: PRK05362
696281008756	Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676
696281008757	XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798
696281008758	tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225
696281008759	active site
696281008760	Int/Topo IB signature motif; other site
696281008761	Protein of unknown function (DUF441); Region: DUF441; pfam04284
696281008762	Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269
696281008763	Integral membrane protein DUF95; Region: DUF95; cl00572
696281008764	Protein of unknown function (DUF3795); Region: DUF3795; pfam12675
696281008765	Protein of unknown function (DUF3866); Region: DUF3866; pfam12982
696281008766	M20 Peptidase T like enzymes specifically cleave tripeptides; Region: M20_peptT_like; cd05683
696281008767	peptidase T-like protein; Region: PepT-like; TIGR01883
696281008768	metal binding site [ion binding]; metal-binding site
696281008769	putative dimer interface [polypeptide binding]; other site
696281008770	Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014
696281008771	2-oxoglutarate ferredoxin oxidoreductase subunit gamma; Validated; Region: PRK08537
696281008772	Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, beta subunit [Energy production and conversion]; Region: PorB; COG1013
696281008773	Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375
696281008774	TPP-binding site [chemical binding]; other site
696281008775	2-ketoisovalerate ferredoxin reductase; Validated; Region: PRK07119
696281008776	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
696281008777	dimer interface [polypeptide binding]; other site
696281008778	PYR/PP interface [polypeptide binding]; other site
696281008779	TPP binding site [chemical binding]; other site
696281008780	substrate binding site [chemical binding]; other site
696281008781	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
696281008782	4Fe-4S dicluster domain; Region: Fer4_10; pfam13237
696281008783	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
696281008784	Glycosyltransferase 4 (GT4) includes both eukaryotic and prokaryotic UDP-D-N-acetylhexosamine:polyprenol phosphate D-N-acetylhexosamine-1-phosphate transferases. They catalyze the transfer of a D-N-acetylhexosamine 1-phosphate to a membrane-bound...; Region: GT_MraY-like; cl10571
696281008785	putative catalytic motif [active]
696281008786	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
696281008787	Ligand binding site; other site
696281008788	Putative Catalytic site; other site
696281008789	DXD motif; other site
696281008790	Protein of unknown function (DUF3186); Region: DUF3186; pfam11382
696281008791	Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4825
696281008792	Thiamine pyrophosphokinase; Region: TPK; cl08415
696281008793	Thiamine pyrophosphokinase C terminal; Region: TPPK_C; pfam12555
696281008794	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
696281008795	dimer interface [polypeptide binding]; other site
696281008796	putative CheW interface [polypeptide binding]; other site
696281008797	MCP-signal associated domain; Region: MCPsignal_assoc; pfam13682
696281008798	Protein of unknown function (DUF1003); Region: DUF1003; cl01831
696281008799	sporulation transcription factor Spo0A; Region: spore_0_A; TIGR02875
696281008800	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
696281008801	active site
696281008802	phosphorylation site [posttranslational modification]
696281008803	intermolecular recognition site; other site
696281008804	dimerization interface [polypeptide binding]; other site
696281008805	Sporulation initiation factor Spo0A C terminal; Region: Spo0A_C; pfam08769
696281008806	stage IV sporulation protein B; Region: spore_IV_B; TIGR02860
696281008807	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
696281008808	SpoIVB peptidase S55; Region: Peptidase_S55; pfam05580
696281008809	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497
696281008810	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
696281008811	Walker A/P-loop; other site
696281008812	ATP binding site [chemical binding]; other site
696281008813	Q-loop/lid; other site
696281008814	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
696281008815	ABC transporter signature motif; other site
696281008816	Walker B; other site
696281008817	D-loop; other site
696281008818	H-loop/switch region; other site
696281008819	Arginine repressor [Transcription]; Region: ArgR; COG1438
696281008820	Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316
696281008821	Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863
696281008822	Putative rRNA methylase; Region: rRNA_methylase; pfam06962
696281008823	NAD kinase [Coenzyme metabolism]; Region: nadF; cl01255
696281008824	ATP-NAD kinase; Region: NAD_kinase; pfam01513
696281008825	Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189
696281008826	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
696281008827	RNA binding surface [nucleotide binding]; other site
696281008828	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
696281008829	S-adenosylmethionine binding site [chemical binding]; other site
696281008830	1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444
696281008831	Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007
696281008832	TPP-binding site; other site
696281008833	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
696281008834	PYR/PP interface [polypeptide binding]; other site
696281008835	dimer interface [polypeptide binding]; other site
696281008836	TPP binding site [chemical binding]; other site
696281008837	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
696281008838	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
696281008839	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
696281008840	substrate binding pocket [chemical binding]; other site
696281008841	chain length determination region; other site
696281008842	substrate-Mg2+ binding site; other site
696281008843	catalytic residues [active]
696281008844	aspartate-rich region 1; other site
696281008845	active site lid residues [active]
696281008846	aspartate-rich region 2; other site
696281008847	exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977
696281008848	Formiminotransferase-cyclodeaminase; Region: FTCD_C; pfam04961
696281008849	5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme metabolism]; Region: FolD; COG0190
696281008850	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
696281008851	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
696281008852	homodimer interface [polypeptide binding]; other site
696281008853	NADP binding site [chemical binding]; other site
696281008854	substrate binding site [chemical binding]; other site
696281008855	exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286
696281008856	ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489
696281008857	generic binding surface II; other site
696281008858	generic binding surface I; other site
696281008859	putative oxidoreductase; Provisional; Region: PRK12831
696281008860	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
696281008861	ferredoxin-NADP(+) reductase subunit alpha; Reviewed; Region: PRK06222
696281008862	FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase-like proteins. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)...; Region: DHOD_e_trans_like1; cd06219
696281008863	FAD binding pocket [chemical binding]; other site
696281008864	FAD binding motif [chemical binding]; other site
696281008865	phosphate binding motif [ion binding]; other site
696281008866	beta-alpha-beta structure motif; other site
696281008867	NAD binding pocket [chemical binding]; other site
696281008868	Iron coordination center [ion binding]; other site
696281008869	Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619
696281008870	putative RNA binding site [nucleotide binding]; other site
696281008871	Small integral membrane protein (DUF2273); Region: DUF2273; pfam10031
696281008872	Asp23 family; Region: Asp23; pfam03780
696281008873	Asp23 family; Region: Asp23; pfam03780
696281008874	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
696281008875	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
696281008876	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
696281008877	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
696281008878	pyruvate carboxylase subunit B; Validated; Region: PRK09282
696281008879	Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937
696281008880	active site
696281008881	catalytic residues [active]
696281008882	metal binding site [ion binding]; metal-binding site
696281008883	homodimer binding site [polypeptide binding]; other site
696281008884	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
696281008885	carboxyltransferase (CT) interaction site; other site
696281008886	biotinylation site [posttranslational modification]; other site
696281008887	SpoIIIAH-like protein; Region: SpoIIIAH; pfam12685
696281008888	stage III sporulation protein AG; Region: spore_III_AG; TIGR02830
696281008889	Stage III sporulation protein AF (Spore_III_AF); Region: Spore_III_AF; pfam09581
696281008890	Stage III sporulation protein AE (spore_III_AE); Region: Spore_III_AE; pfam09546
696281008891	stage III sporulation protein AD; Region: spore_III_AD; TIGR02849
696281008892	Stage III sporulation protein AC/AD protein family; Region: SpoIIIAC; cl05961
696281008893	stage III sporulation protein SpoAB; Provisional; Region: PRK08307
696281008894	stage III sporulation protein AA; Region: spore_III_AA; TIGR02858
696281008895	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
696281008896	Walker A motif; other site
696281008897	ATP binding site [chemical binding]; other site
696281008898	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
696281008899	coenzyme A disulfide reductase; Reviewed; Region: PRK09564
696281008900	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
696281008901	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
696281008902	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
696281008903	active site residue [active]
696281008904	3-deoxy-7-phosphoheptulonate synthase; Reviewed; Region: PRK08673
696281008905	3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase [Cell envelope biogenesis, outer membrane]; Region: KdsA; cl17225
696281008906	elongation factor P; Validated; Region: PRK00529
696281008907	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
696281008908	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
696281008909	RNA binding site [nucleotide binding]; other site
696281008910	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
696281008911	RNA binding site [nucleotide binding]; other site
696281008912	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
696281008913	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
696281008914	Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092
696281008915	active site
696281008916	Dehydroquinase class II; Region: DHquinase_II; pfam01220
696281008917	Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466
696281008918	trimer interface [polypeptide binding]; other site
696281008919	active site
696281008920	dimer interface [polypeptide binding]; other site
696281008921	Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312
696281008922	YabG peptidase U57; Region: Peptidase_U57; cl05250
696281008923	Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312
696281008924	Tfp pilus assembly protein PilN [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilN; COG3166
696281008925	Tfp pilus assembly protein, ATPase PilM [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilM; COG4972
696281008926	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
696281008927	PilX N-terminal; Region: PilX_N; pfam14341
696281008928	Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334
696281008929	Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334
696281008930	Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459
696281008931	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
696281008932	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
696281008933	Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805
696281008934	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
696281008935	Walker A motif; other site
696281008936	ATP binding site [chemical binding]; other site
696281008937	Walker B motif; other site
696281008938	type IV-A pilus assembly ATPase PilB; Region: type_IV_pilB; TIGR02538
696281008939	Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157
696281008940	PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129
696281008941	Walker A motif; other site
696281008942	ATP binding site [chemical binding]; other site
696281008943	Walker B motif; other site
696281008944	Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989
696281008945	Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750
696281008946	Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195
696281008947	active site
696281008948	dimer interface [polypeptide binding]; other site
696281008949	metal binding site [ion binding]; metal-binding site
696281008950	shikimate kinase; Provisional; Region: PRK13947
696281008951	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
696281008952	ADP binding site [chemical binding]; other site
696281008953	magnesium binding site [ion binding]; other site
696281008954	putative shikimate binding site; other site
696281008955	Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082
696281008956	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
696281008957	Tetramer interface [polypeptide binding]; other site
696281008958	active site
696281008959	FMN-binding site [chemical binding]; other site
696281008960	shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258
696281008961	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
696281008962	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
696281008963	shikimate binding site; other site
696281008964	NAD(P) binding site [chemical binding]; other site
696281008965	Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179
696281008966	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
696281008967	active site
696281008968	motif I; other site
696281008969	motif II; other site
696281008970	RNA polymerase sigma-K factor; Region: spore_sigmaK; TIGR02846
696281008971	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
696281008972	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
696281008973	DNA binding residues [nucleotide binding]
696281008974	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
696281008975	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
696281008976	non-specific DNA binding site [nucleotide binding]; other site
696281008977	salt bridge; other site
696281008978	sequence-specific DNA binding site [nucleotide binding]; other site
696281008979	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
696281008980	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
696281008981	Zn2+ binding site [ion binding]; other site
696281008982	Mg2+ binding site [ion binding]; other site
696281008983	FOG: CBS domain [General function prediction only]; Region: COG0517
696281008984	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
696281008985	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
696281008986	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
696281008987	metal binding site [ion binding]; metal-binding site
696281008988	active site
696281008989	I-site; other site
696281008990	Response regulator receiver domain; Region: Response_reg; pfam00072
696281008991	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
696281008992	active site
696281008993	phosphorylation site [posttranslational modification]
696281008994	intermolecular recognition site; other site
696281008995	dimerization interface [polypeptide binding]; other site
696281008996	Response regulator receiver domain; Region: Response_reg; pfam00072
696281008997	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
696281008998	active site
696281008999	phosphorylation site [posttranslational modification]
696281009000	intermolecular recognition site; other site
696281009001	dimerization interface [polypeptide binding]; other site
696281009002	PAS domain S-box; Region: sensory_box; TIGR00229
696281009003	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
696281009004	putative active site [active]
696281009005	heme pocket [chemical binding]; other site
696281009006	GAF domain; Region: GAF_2; pfam13185
696281009007	GAF domain; Region: GAF; pfam01590
696281009008	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
696281009009	nitrogen fixation negative regulator NifL; Region: nifL_nitrog; TIGR02938
696281009010	putative active site [active]
696281009011	heme pocket [chemical binding]; other site
696281009012	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
696281009013	putative active site [active]
696281009014	heme pocket [chemical binding]; other site
696281009015	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
696281009016	dimer interface [polypeptide binding]; other site
696281009017	phosphorylation site [posttranslational modification]
696281009018	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
696281009019	ATP binding site [chemical binding]; other site
696281009020	G-X-G motif; other site
696281009021	Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675
696281009022	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
696281009023	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
696281009024	metal binding site [ion binding]; metal-binding site
696281009025	active site
696281009026	I-site; other site
696281009027	Helix-turn-helix domain; Region: HTH_28; pfam13518
696281009028	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
696281009029	Helix-turn-helix domain; Region: HTH_28; pfam13518
696281009030	putative transposase OrfB; Reviewed; Region: PHA02517
696281009031	HTH-like domain; Region: HTH_21; pfam13276
696281009032	Integrase core domain; Region: rve; pfam00665
696281009033	Integrase core domain; Region: rve_2; pfam13333
696281009034	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
696281009035	Hexulose-6-phosphate isomerase (PHI). PHI is a member of the SIS (Sugar ISomerase domain) superfamily. In the ribulose monophosphate pathway of formaldehyde fixation, hexulose-6-phosphate synthase catalyzes the condensation of ribulose-5-phosphate with...; Region: SIS_PHI; cd05005
696281009036	tetramer interface [polypeptide binding]; other site
696281009037	active site
696281009038	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
696281009039	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
696281009040	Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167
696281009041	putative substrate binding site [chemical binding]; other site
696281009042	putative ATP binding site [chemical binding]; other site
696281009043	Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808
696281009044	N- and C-terminal domain interface [polypeptide binding]; other site
696281009045	D-xylulose kinase; Region: XylB; TIGR01312
696281009046	active site
696281009047	MgATP binding site [chemical binding]; other site
696281009048	catalytic site [active]
696281009049	metal binding site [ion binding]; metal-binding site
696281009050	xylulose binding site [chemical binding]; other site
696281009051	homodimer interface [polypeptide binding]; other site
696281009052	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
696281009053	L-threonine dehydrogenase; Region: threonine_DH_like; cd08234
696281009054	putative NAD(P) binding site [chemical binding]; other site
696281009055	catalytic Zn binding site [ion binding]; other site
696281009056	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
696281009057	Sorbitol dehydrogenase; Region: sorbitol_DH; cd05285
696281009058	inhibitor binding site; inhibition site
696281009059	catalytic Zn binding site [ion binding]; other site
696281009060	structural Zn binding site [ion binding]; other site
696281009061	NADP binding site [chemical binding]; other site
696281009062	tetramer interface [polypeptide binding]; other site
696281009063	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
696281009064	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
696281009065	dimer interface [polypeptide binding]; other site
696281009066	conserved gate region; other site
696281009067	putative PBP binding loops; other site
696281009068	ABC-ATPase subunit interface; other site
696281009069	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
696281009070	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
696281009071	dimer interface [polypeptide binding]; other site
696281009072	conserved gate region; other site
696281009073	putative PBP binding loops; other site
696281009074	ABC-ATPase subunit interface; other site
696281009075	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
696281009076	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
696281009077	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
696281009078	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
696281009079	Walker A/P-loop; other site
696281009080	ATP binding site [chemical binding]; other site
696281009081	Q-loop/lid; other site
696281009082	ABC transporter signature motif; other site
696281009083	Walker B; other site
696281009084	D-loop; other site
696281009085	H-loop/switch region; other site
696281009086	TOBE domain; Region: TOBE_2; pfam08402
696281009087	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
696281009088	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
696281009089	substrate binding site [chemical binding]; other site
696281009090	ATP binding site [chemical binding]; other site
696281009091	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
696281009092	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
696281009093	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
696281009094	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
696281009095	intersubunit interface [polypeptide binding]; other site
696281009096	active site
696281009097	zinc binding site [ion binding]; other site
696281009098	Na+ binding site [ion binding]; other site
696281009099	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
696281009100	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
696281009101	active site residue [active]
696281009102	Protein of unknown function (DUF3243); Region: DUF3243; pfam11588
696281009103	Prolipoprotein diacylglyceryl transferase; Region: LGT; pfam01790
696281009104	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
696281009105	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
696281009106	catalytic residues [active]
696281009107	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
696281009108	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
696281009109	non-specific DNA binding site [nucleotide binding]; other site
696281009110	salt bridge; other site
696281009111	sequence-specific DNA binding site [nucleotide binding]; other site
696281009112	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
696281009113	non-specific DNA binding site [nucleotide binding]; other site
696281009114	salt bridge; other site
696281009115	sequence-specific DNA binding site [nucleotide binding]; other site
696281009116	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
696281009117	non-specific DNA binding site [nucleotide binding]; other site
696281009118	salt bridge; other site
696281009119	sequence-specific DNA binding site [nucleotide binding]; other site
696281009120	penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423
696281009121	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
696281009122	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
696281009123	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
696281009124	Peptidase family U32; Region: Peptidase_U32; pfam01136
696281009125	YceG-like family; Region: YceG; pfam02618
696281009126	proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010
696281009127	dimerization interface [polypeptide binding]; other site
696281009128	ArgK protein; Region: ArgK; pfam03308
696281009129	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
696281009130	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
696281009131	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
696281009132	DNA binding residues [nucleotide binding]
696281009133	Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229
696281009134	VanW like protein; Region: VanW; pfam04294
696281009135	G5 domain; Region: G5; pfam07501
696281009136	Protein of unknown function (DUF1292); Region: DUF1292; pfam06949
696281009137	Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652
696281009138	hypothetical protein; Provisional; Region: PRK05473
696281009139	Predicted membrane protein [Function unknown]; Region: COG2323
696281009140	Domain of unknown function (DUF4363); Region: DUF4363; pfam14276
696281009141	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
696281009142	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673
696281009143	motif 1; other site
696281009144	active site
696281009145	motif 2; other site
696281009146	motif 3; other site
696281009147	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
696281009148	DHHA1 domain; Region: DHHA1; pfam02272
696281009149	Domain of unknown function DUF20; Region: UPF0118; pfam01594
696281009150	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
696281009151	Zinc dependent phospholipase C (alpha toxin); Region: Zn_dep_PLPC; cd11009
696281009152	Zn binding site [ion binding]; other site
696281009153	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
696281009154	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814
696281009155	putative hydrolase; Validated; Region: PRK09248
696281009156	Polymerase and Histidinol Phosphatase domain of Ycdx like; Region: PHP_HisPPase_Ycdx_like; cd07437
696281009157	active site
696281009158	tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054
696281009159	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
696281009160	Ligand Binding Site [chemical binding]; other site
696281009161	NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822
696281009162	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
696281009163	trimerization site [polypeptide binding]; other site
696281009164	active site
696281009165	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
696281009166	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
696281009167	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
696281009168	catalytic residue [active]
696281009169	Transcriptional regulator; Region: Rrf2; cl17282
696281009170	Rrf2 family protein; Region: rrf2_super; TIGR00738
696281009171	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
696281009172	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
696281009173	catalytic residues [active]
696281009174	Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179
696281009175	Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755
696281009176	putative ATP binding site [chemical binding]; other site
696281009177	putative substrate interface [chemical binding]; other site
696281009178	heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386
696281009179	HAMP domain; Region: HAMP; pfam00672
696281009180	dimerization interface [polypeptide binding]; other site
696281009181	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
696281009182	dimer interface [polypeptide binding]; other site
696281009183	phosphorylation site [posttranslational modification]
696281009184	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
696281009185	ATP binding site [chemical binding]; other site
696281009186	Mg2+ binding site [ion binding]; other site
696281009187	G-X-G motif; other site
696281009188	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
696281009189	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
696281009190	active site
696281009191	phosphorylation site [posttranslational modification]
696281009192	intermolecular recognition site; other site
696281009193	dimerization interface [polypeptide binding]; other site
696281009194	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
696281009195	DNA binding site [nucleotide binding]
696281009196	periplasmic serine pepetdase DegS; Region: protease_degS; TIGR02038
696281009197	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
696281009198	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
696281009199	protein binding site [polypeptide binding]; other site
696281009200	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
696281009201	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
696281009202	dimer interface [polypeptide binding]; other site
696281009203	anticodon binding site; other site
696281009204	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
696281009205	homodimer interface [polypeptide binding]; other site
696281009206	motif 1; other site
696281009207	active site
696281009208	motif 2; other site
696281009209	GAD domain; Region: GAD; pfam02938
696281009210	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
696281009211	motif 3; other site
696281009212	histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037
696281009213	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
696281009214	dimer interface [polypeptide binding]; other site
696281009215	motif 1; other site
696281009216	active site
696281009217	motif 2; other site
696281009218	motif 3; other site
696281009219	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
696281009220	anticodon binding site; other site
696281009221	Bacterial protein of unknown function (DUF896); Region: DUF896; pfam05979
696281009222	Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011
696281009223	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
696281009224	active site
696281009225	motif II; other site
696281009226	ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891
696281009227	Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732
696281009228	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
696281009229	dimer interface [polypeptide binding]; other site
696281009230	conserved gate region; other site
696281009231	ABC-ATPase subunit interface; other site
696281009232	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
696281009233	dimer interface [polypeptide binding]; other site
696281009234	conserved gate region; other site
696281009235	ABC-ATPase subunit interface; other site
696281009236	ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125
696281009237	ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295
696281009238	Walker A/P-loop; other site
696281009239	ATP binding site [chemical binding]; other site
696281009240	Q-loop/lid; other site
696281009241	ABC transporter signature motif; other site
696281009242	Walker B; other site
696281009243	D-loop; other site
696281009244	H-loop/switch region; other site
696281009245	FOG: CBS domain [General function prediction only]; Region: COG0517
696281009246	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583
696281009247	Methyltransferase domain; Region: Methyltransf_23; pfam13489
696281009248	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
696281009249	S-adenosylmethionine binding site [chemical binding]; other site
696281009250	RNA polymerase sigma-70 factor, TIGR02952 family; Region: Sig70_famx2
696281009251	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
696281009252	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
696281009253	DNA binding residues [nucleotide binding]
696281009254	Domain of unknown function (DUF4367); Region: DUF4367; pfam14285
696281009255	Transposase; Region: DEDD_Tnp_IS110; pfam01548
696281009256	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
696281009257	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
696281009258	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
696281009259	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
696281009260	active site
696281009261	phosphorylation site [posttranslational modification]
696281009262	intermolecular recognition site; other site
696281009263	dimerization interface [polypeptide binding]; other site
696281009264	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
696281009265	DNA binding residues [nucleotide binding]
696281009266	dimerization interface [polypeptide binding]; other site
696281009267	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
696281009268	Histidine kinase; Region: HisKA_3; pfam07730
696281009269	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
696281009270	ATP binding site [chemical binding]; other site
696281009271	Mg2+ binding site [ion binding]; other site
696281009272	G-X-G motif; other site
696281009273	putative NADPH-dependent glutamate synthase small subunit; Provisional; Region: PRK12814
696281009274	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
696281009275	catalytic loop [active]
696281009276	iron binding site [ion binding]; other site
696281009277	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
696281009278	molybdopterin cofactor binding site; other site
696281009279	Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257
696281009280	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064
696281009281	putative dimer interface [polypeptide binding]; other site
696281009282	[2Fe-2S] cluster binding site [ion binding]; other site
696281009283	Protein of unknown function (DUF2837); Region: DUF2837; pfam10997
696281009284	Protein of unknown function (DUF2599); Region: DUF2599; pfam10783
696281009285	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
696281009286	catalytic residues [active]
696281009287	LytTr DNA-binding domain; Region: LytTR; pfam04397
696281009288	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
696281009289	active site residue [active]
696281009290	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
696281009291	DNA-binding interface [nucleotide binding]; DNA binding site
696281009292	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
696281009293	HTH-like domain; Region: HTH_21; pfam13276
696281009294	Integrase core domain; Region: rve; pfam00665
696281009295	Integrase core domain; Region: rve_3; pfam13683
696281009296	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
696281009297	DNA-binding interface [nucleotide binding]; DNA binding site
696281009298	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
696281009299	HTH-like domain; Region: HTH_21; pfam13276
696281009300	Integrase core domain; Region: rve; pfam00665
696281009301	Integrase core domain; Region: rve_3; pfam13683
696281009302	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
696281009303	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
696281009304	active site
696281009305	phosphorylation site [posttranslational modification]
696281009306	intermolecular recognition site; other site
696281009307	dimerization interface [polypeptide binding]; other site
696281009308	LytTr DNA-binding domain; Region: LytTR; pfam04397
696281009309	Staphylococcal AgrD protein; Region: AgrD; cl05477
696281009310	Accessory gene regulator B; Region: AgrB; pfam04647
696281009311	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
696281009312	ATP binding site [chemical binding]; other site
696281009313	Mg2+ binding site [ion binding]; other site
696281009314	G-X-G motif; other site
696281009315	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
696281009316	Predicted membrane protein [Function unknown]; Region: COG2364
696281009317	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
696281009318	Transcriptional regulator [Transcription]; Region: LysR; COG0583
696281009319	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
696281009320	The C-terminal substrate binding domain of LysR-like transcriptional regulator CidR, contains the type 2 periplasmic binding fold; Region: PBP2_CidR; cd08438
696281009321	putative dimerization interface [polypeptide binding]; other site
696281009322	Protein of unknown function (DUF401); Region: DUF401; cl00830
696281009323	Predicted membrane protein [Function unknown]; Region: COG2119
696281009324	Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169
696281009325	Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169
696281009326	L-type amino acid transporter; Region: 2A0308; TIGR00911
696281009327	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
696281009328	The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods.  Chitinases have...; Region: GH18_chitinase-like; cl10447
696281009329	active site
696281009330	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
696281009331	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
696281009332	dimer interface [polypeptide binding]; other site
696281009333	conserved gate region; other site
696281009334	putative PBP binding loops; other site
696281009335	ABC-ATPase subunit interface; other site
696281009336	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
696281009337	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
696281009338	Walker A/P-loop; other site
696281009339	ATP binding site [chemical binding]; other site
696281009340	Q-loop/lid; other site
696281009341	ABC transporter signature motif; other site
696281009342	Walker B; other site
696281009343	D-loop; other site
696281009344	H-loop/switch region; other site
696281009345	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
696281009346	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432
696281009347	nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055
696281009348	Ferritin-like domain; Region: Ferritin; pfam00210
696281009349	ferroxidase diiron center [ion binding]; other site
696281009350	Rubredoxin [Energy production and conversion]; Region: COG1773
696281009351	Rubredoxin_like; nonheme iron binding domain containing a [Fe(SCys)4] center. The family includes rubredoxins, a small electron transfer protein, and a slightly smaller modular rubredoxin domain present in rubrerythrin and nigerythrin and detected either...; Region: rubredoxin_like; cl00202
696281009352	iron binding site [ion binding]; other site
696281009353	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
696281009354	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
696281009355	Walker A/P-loop; other site
696281009356	ATP binding site [chemical binding]; other site
696281009357	Q-loop/lid; other site
696281009358	ABC transporter signature motif; other site
696281009359	Walker B; other site
696281009360	D-loop; other site
696281009361	H-loop/switch region; other site
696281009362	Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069
696281009363	ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891
696281009364	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
696281009365	dimer interface [polypeptide binding]; other site
696281009366	conserved gate region; other site
696281009367	putative PBP binding loops; other site
696281009368	ABC-ATPase subunit interface; other site
696281009369	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
696281009370	Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090
696281009371	NAD(P) binding site [chemical binding]; other site
696281009372	active site
696281009373	Protein of unknown function DUF86; Region: DUF86; pfam01934
696281009374	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
696281009375	active site
696281009376	NTP binding site [chemical binding]; other site
696281009377	metal binding triad [ion binding]; metal-binding site
696281009378	antibiotic binding site [chemical binding]; other site
696281009379	Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936
696281009380	NodB motif; other site
696281009381	putative active site [active]
696281009382	putative catalytic site [active]
696281009383	Zn binding site [ion binding]; other site
696281009384	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
696281009385	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
696281009386	active site
696281009387	metal binding site [ion binding]; metal-binding site
696281009388	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
696281009389	Walker A/P-loop; other site
696281009390	ATP binding site [chemical binding]; other site
696281009391	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
696281009392	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
696281009393	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
696281009394	EamA-like transporter family; Region: EamA; pfam00892
696281009395	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
696281009396	EamA-like transporter family; Region: EamA; pfam00892
696281009397	cobalt transport protein CbiM; Validated; Region: PRK08319
696281009398	Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891
696281009399	cobalt transport protein CbiN; Provisional; Region: PRK02898
696281009400	cobalt ABC transporter, permease protein CbiQ; Region: CbiQ_TIGR; TIGR02454
696281009401	cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13639
696281009402	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
696281009403	Walker A/P-loop; other site
696281009404	ATP binding site [chemical binding]; other site
696281009405	Q-loop/lid; other site
696281009406	ABC transporter signature motif; other site
696281009407	Walker B; other site
696281009408	D-loop; other site
696281009409	H-loop/switch region; other site
696281009410	Uncharacterized conserved protein [Function unknown]; Region: COG0327
696281009411	NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784
696281009412	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
696281009413	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
696281009414	Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; pfam01832
696281009415	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
696281009416	endonuclease III; Region: ENDO3c; smart00478
696281009417	minor groove reading motif; other site
696281009418	helix-hairpin-helix signature motif; other site
696281009419	substrate binding pocket [chemical binding]; other site
696281009420	active site
696281009421	methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901
696281009422	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
696281009423	DNA binding site [nucleotide binding]
696281009424	active site
696281009425	Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169
696281009426	Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805
696281009427	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
696281009428	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
696281009429	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
696281009430	Predicted flavoprotein [General function prediction only]; Region: COG0431
696281009431	S-adenosylmethionine decarboxylase; Provisional; Region: PRK05462
696281009432	hydrogenase 4 subunit B; Validated; Region: PRK06521
696281009433	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
696281009434	NADH dehydrogenase; Region: NADHdh; cl00469
696281009435	Hydrogenase 4 membrane component (E) [Energy production and conversion]; Region: HyfE; cl17899
696281009436	hydrogenase 4 subunit F; Validated; Region: PRK06458
696281009437	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
696281009438	Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; pfam00329
696281009439	Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261
696281009440	NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338
696281009441	4Fe-4S dicluster domain; Region: Fer4_9; pfam13187
696281009442	Ni,Fe-hydrogenase III small subunit [Energy production and conversion]; Region: COG3260
696281009443	Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095
696281009444	lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545
696281009445	Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437
696281009446	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
696281009447	D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563
696281009448	putative active site [active]
696281009449	dimerization interface [polypeptide binding]; other site
696281009450	putative tRNAtyr binding site [nucleotide binding]; other site
696281009451	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
696281009452	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
696281009453	Zn2+ binding site [ion binding]; other site
696281009454	Mg2+ binding site [ion binding]; other site
696281009455	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
696281009456	synthetase active site [active]
696281009457	NTP binding site [chemical binding]; other site
696281009458	metal binding site [ion binding]; metal-binding site
696281009459	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
696281009460	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
696281009461	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
696281009462	active site
696281009463	single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644
696281009464	DHH family; Region: DHH; pfam01368
696281009465	DHHA1 domain; Region: DHHA1; pfam02272
696281009466	phenylalanyl-tRNA synthetase subunit alpha; Provisional; Region: pheS; PRK04172
696281009467	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
696281009468	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
696281009469	Walker A/P-loop; other site
696281009470	ATP binding site [chemical binding]; other site
696281009471	Q-loop/lid; other site
696281009472	ABC transporter signature motif; other site
696281009473	Walker B; other site
696281009474	D-loop; other site
696281009475	H-loop/switch region; other site
696281009476	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
696281009477	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
696281009478	dimer interface [polypeptide binding]; other site
696281009479	conserved gate region; other site
696281009480	putative PBP binding loops; other site
696281009481	ABC-ATPase subunit interface; other site
696281009482	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
696281009483	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
696281009484	substrate binding pocket [chemical binding]; other site
696281009485	membrane-bound complex binding site; other site
696281009486	hinge residues; other site
696281009487	putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272
696281009488	EamA-like transporter family; Region: EamA; pfam00892
696281009489	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
696281009490	cation diffusion facilitator family transporter; Region: CDF; TIGR01297
696281009491	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
696281009492	tetramer interface [polypeptide binding]; other site
696281009493	pyridoxal 5'-phosphate binding site [chemical binding]; other site
696281009494	catalytic residue [active]
696281009495	Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403
696281009496	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
696281009497	tetramer interface [polypeptide binding]; other site
696281009498	pyridoxal 5'-phosphate binding site [chemical binding]; other site
696281009499	catalytic residue [active]
696281009500	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
696281009501	lipoyl attachment site [posttranslational modification]; other site
696281009502	glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389
696281009503	Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893
696281009504	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
696281009505	Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269
696281009506	isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743
696281009507	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
696281009508	active site
696281009509	HIGH motif; other site
696281009510	nucleotide binding site [chemical binding]; other site
696281009511	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
696281009512	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
696281009513	active site
696281009514	KMSKS motif; other site
696281009515	Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960
696281009516	tRNA binding surface [nucleotide binding]; other site
696281009517	anticodon binding site; other site
696281009518	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
696281009519	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
696281009520	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
696281009521	active site residue [active]
696281009522	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
696281009523	MarR family; Region: MarR; pfam01047
696281009524	MarR family; Region: MarR_2; cl17246
696281009525	HEAT repeats; Region: HEAT_2; pfam13646
696281009526	putative lyase; Provisional; Region: PRK09687
696281009527	E-Z type HEAT repeats; Region: EZ_HEAT; smart00567
696281009528	HEAT repeats; Region: HEAT_2; pfam13646
696281009529	HEAT repeats; Region: HEAT_2; pfam13646
696281009530	HEAT repeats; Region: HEAT_2; pfam13646
696281009531	Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin; Region: ARM; cd00020
696281009532	protein binding surface [polypeptide binding]; other site
696281009533	HEAT repeats; Region: HEAT_2; pfam13646
696281009534	HEAT repeats; Region: HEAT_2; pfam13646
696281009535	O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315
696281009536	Leucine carboxyl methyltransferase; Region: LCM; pfam04072
696281009537	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
696281009538	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
696281009539	dimerization interface [polypeptide binding]; other site
696281009540	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
696281009541	dimer interface [polypeptide binding]; other site
696281009542	phosphorylation site [posttranslational modification]
696281009543	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
696281009544	ATP binding site [chemical binding]; other site
696281009545	Mg2+ binding site [ion binding]; other site
696281009546	G-X-G motif; other site
696281009547	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
696281009548	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
696281009549	active site
696281009550	phosphorylation site [posttranslational modification]
696281009551	intermolecular recognition site; other site
696281009552	dimerization interface [polypeptide binding]; other site
696281009553	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
696281009554	DNA binding site [nucleotide binding]
696281009555	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
696281009556	Coenzyme A binding pocket [chemical binding]; other site
696281009557	VanW like protein; Region: VanW; pfam04294
696281009558	phosphoenolpyruvate synthase; Validated; Region: PRK06241
696281009559	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
696281009560	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
696281009561	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
696281009562	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
696281009563	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
696281009564	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
696281009565	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
696281009566	QacR-like protein, C-terminal region; Region: TetR_C_5; pfam08360
696281009567	Methyltransferase domain; Region: Methyltransf_31; pfam13847
696281009568	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
696281009569	S-adenosylmethionine binding site [chemical binding]; other site
696281009570	Uncharacterized ACR, YggU family COG1872; Region: DUF167; pfam02594
696281009571	DivIVA protein; Region: DivIVA; pfam05103
696281009572	DivIVA domain; Region: DivI1A_domain; TIGR03544
696281009573	Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302
696281009574	YGGT family; Region: YGGT; pfam02325
696281009575	Protein of unknown function (DUF552); Region: DUF552; pfam04472
696281009576	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635
696281009577	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
696281009578	catalytic residue [active]
696281009579	HlyD family secretion protein; Region: HlyD_2; pfam12700
696281009580	putative membrane fusion protein; Region: TIGR02828
696281009581	phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135
696281009582	PhoU domain; Region: PhoU; pfam01895
696281009583	PhoU domain; Region: PhoU; pfam01895
696281009584	ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117
696281009585	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
696281009586	Walker A/P-loop; other site
696281009587	ATP binding site [chemical binding]; other site
696281009588	Q-loop/lid; other site
696281009589	ABC transporter signature motif; other site
696281009590	Walker B; other site
696281009591	D-loop; other site
696281009592	H-loop/switch region; other site
696281009593	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
696281009594	dimerization interface [polypeptide binding]; other site
696281009595	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
696281009596	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
696281009597	putative active site [active]
696281009598	heme pocket [chemical binding]; other site
696281009599	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
696281009600	dimer interface [polypeptide binding]; other site
696281009601	phosphorylation site [posttranslational modification]
696281009602	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
696281009603	ATP binding site [chemical binding]; other site
696281009604	Mg2+ binding site [ion binding]; other site
696281009605	G-X-G motif; other site
696281009606	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
696281009607	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
696281009608	active site
696281009609	phosphorylation site [posttranslational modification]
696281009610	intermolecular recognition site; other site
696281009611	dimerization interface [polypeptide binding]; other site
696281009612	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
696281009613	DNA binding site [nucleotide binding]
696281009614	Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496
696281009615	Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578
696281009616	Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236
696281009617	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
696281009618	Beta-Casp domain; Region: Beta-Casp; smart01027
696281009619	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
696281009620	Zinc ribbon domain; Region: CxxC_CxxC_SSSS; pfam09723
696281009621	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
696281009622	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
696281009623	Intracellular proteinase inhibitor; Region: BsuPI; pfam12690
696281009624	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
696281009625	S-adenosylmethionine binding site [chemical binding]; other site
696281009626	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
696281009627	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
696281009628	ligand binding site [chemical binding]; other site
696281009629	flexible hinge region; other site
696281009630	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
696281009631	putative switch regulator; other site
696281009632	non-specific DNA interactions [nucleotide binding]; other site
696281009633	DNA binding site [nucleotide binding]
696281009634	sequence specific DNA binding site [nucleotide binding]; other site
696281009635	putative cAMP binding site [chemical binding]; other site
696281009636	carbon-monoxide dehydrogenase, catalytic subunit; Region: CO_DH_cata; TIGR01702
696281009637	Carbon monoxide dehydrogenase (CODH) is found in acetogenic and methanogenic organisms and is responsible for the synthesis and breakdown of acetyl-CoA, respectively. CODH has two types of metal clusters, a cubane [Fe4-S4] center (B-cluster) similar to...; Region: CODH; cd01915
696281009638	ACS interaction site; other site
696281009639	CODH interaction site; other site
696281009640	cubane metal cluster (B-cluster) [ion binding]; other site
696281009641	Ni-Fe-S cluster (C-cluster) [ion binding]; other site
696281009642	Flavin reductase like domain; Region: Flavin_Reduct; pfam01613
696281009643	Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599
696281009644	putative iron-only hydrogenase system regulator; Region: hyd_TM1266; TIGR03959
696281009645	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
696281009646	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
696281009647	hybrid cluster protein-associated redox disulfide domain; Region: prismane_assoc; TIGR03980
696281009648	4Fe-4S single cluster domain; Region: Fer4_12; pfam13353
696281009649	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
696281009650	FeS/SAM binding site; other site
696281009651	ATP cone domain; Region: ATP-cone; pfam03477
696281009652	anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK14704
696281009653	Class III ribonucleotide reductase; Region: RNR_III; cd01675
696281009654	effector binding site; other site
696281009655	active site
696281009656	Zn binding site [ion binding]; other site
696281009657	glycine loop; other site
696281009658	transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464
696281009659	ATP cone domain; Region: ATP-cone; pfam03477
696281009660	spore photoproduct lyase; Region: photo_TT_lyase; TIGR04070
696281009661	DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533
696281009662	Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139
696281009663	Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589
696281009664	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
696281009665	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
696281009666	Cysteine-rich domain; Region: CCG; pfam02754
696281009667	Cysteine-rich domain; Region: CCG; pfam02754
696281009668	Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589
696281009669	sporulation protein, YlmC/YmxH family; Region: spore_YlmC_YmxH; TIGR02888
696281009670	sporulation sigma factor SigG; Reviewed; Region: PRK08215
696281009671	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
696281009672	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
696281009673	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
696281009674	DNA binding residues [nucleotide binding]
696281009675	sporulation sigma factor SigE; Reviewed; Region: PRK08301
696281009676	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
696281009677	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
696281009678	DNA binding residues [nucleotide binding]
696281009679	Sporulation factor SpoIIGA; Region: Peptidase_U4; pfam03419
696281009680	sigma-E processing peptidase SpoIIGA; Region: spore_II_GA; TIGR02854
696281009681	Domain of unknown function (DUF2007); Region: DUF2007; pfam09413
696281009682	cell division protein FtsZ; Validated; Region: PRK09330
696281009683	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
696281009684	nucleotide binding site [chemical binding]; other site
696281009685	SulA interaction site; other site
696281009686	Cell division protein FtsA; Region: FtsA; smart00842
696281009687	Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849
696281009688	Cell division protein FtsA; Region: FtsA; pfam14450
696281009689	Protein of unknown function (DUF1290); Region: DUF1290; pfam06947
696281009690	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3879
696281009691	Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949
696281009692	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
696281009693	Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949
696281009694	POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478
696281009695	Cell division protein FtsQ; Region: FtsQ; pfam03799
696281009696	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
696281009697	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
696281009698	hinge; other site
696281009699	active site
696281009700	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905
696281009701	FAD binding domain; Region: FAD_binding_4; pfam01565
696281009702	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
696281009703	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
696281009704	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
696281009705	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
696281009706	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
696281009707	undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726
696281009708	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
696281009709	homodimer interface [polypeptide binding]; other site
696281009710	active site
696281009711	cell division protein FtsW; Region: ftsW; TIGR02614
696281009712	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK14106
696281009713	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
696281009714	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
696281009715	phospho-N-acetylmuramoyl-pentapeptide-transferase; Region: mraY; TIGR00445
696281009716	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
696281009717	Mg++ binding site [ion binding]; other site
696281009718	putative catalytic motif [active]
696281009719	putative substrate binding site [chemical binding]; other site
696281009720	UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770
696281009721	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
696281009722	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
696281009723	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
696281009724	UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139
696281009725	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
696281009726	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
696281009727	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
696281009728	stage V sporulation protein D; Region: spoVD_pbp; TIGR02214
696281009729	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
696281009730	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
696281009731	PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576
696281009732	PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575
696281009733	Cell division protein FtsL; Region: FtsL; cl11433
696281009734	MraW methylase family; Region: Methyltransf_5; pfam01795
696281009735	16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050
696281009736	cell division protein MraZ; Reviewed; Region: PRK00326
696281009737	MraZ protein; Region: MraZ; pfam02381
696281009738	MraZ protein; Region: MraZ; pfam02381
696281009739	histidinol-phosphatase; Provisional; Region: PRK07328
696281009740	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase of Hisj like; Region: PHP_HisPPase_Hisj_like; cd12110
696281009741	active site
696281009742	dimer interface [polypeptide binding]; other site
696281009743	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
696281009744	Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205
696281009745	active site
696281009746	nucleophile elbow; other site
696281009747	Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396
696281009748	Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829
696281009749	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
696281009750	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
696281009751	putative active site [active]
696281009752	heme pocket [chemical binding]; other site
696281009753	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
696281009754	Walker A motif; other site
696281009755	ATP binding site [chemical binding]; other site
696281009756	Walker B motif; other site
696281009757	arginine finger; other site
696281009758	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
696281009759	Cache domain; Region: Cache_1; pfam02743
696281009760	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
696281009761	dimerization interface [polypeptide binding]; other site
696281009762	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
696281009763	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
696281009764	metal binding site [ion binding]; metal-binding site
696281009765	active site
696281009766	I-site; other site
696281009767	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
696281009768	metal binding site 2 [ion binding]; metal-binding site
696281009769	putative DNA binding helix; other site
696281009770	metal binding site 1 [ion binding]; metal-binding site
696281009771	dimer interface [polypeptide binding]; other site
696281009772	structural Zn2+ binding site [ion binding]; other site
696281009773	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768
696281009774	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
696281009775	Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936
696281009776	Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370
696281009777	Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879
696281009778	G1 box; other site
696281009779	GTP/Mg2+ binding site [chemical binding]; other site
696281009780	Switch I region; other site
696281009781	G2 box; other site
696281009782	G3 box; other site
696281009783	Switch II region; other site
696281009784	G4 box; other site
696281009785	G5 box; other site
696281009786	Nucleoside recognition; Region: Gate; pfam07670
696281009787	Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664
696281009788	This entry represents the core domain of the ferrous iron (Fe2+) transport protein FeoA found in bacteria; Region: FeoA; smart00899
696281009789	Cortical fragment-lytic enzyme (CFLE) is a peptidoglycan hydrolase involved in  bacterial endospore germination.  CFLE is expressed as an inactive preprotein (called SleB) in the forespore compartment of sporulating cells.  SleB translocates across the...; Region: GH18_CFLE_spore_hydrolase; cd02874
696281009790	active site
696281009791	Divergent PAP2 family; Region: DUF212; pfam02681
696281009792	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
696281009793	putative substrate translocation pore; other site
696281009794	Major Facilitator Superfamily; Region: MFS_1; pfam07690
696281009795	Catalytic NodB homology domain of uncharacterized bacterial polysaccharide deacetylases; Region: CE4_NodB_like_3; cd10959
696281009796	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
696281009797	NodB motif; other site
696281009798	putative active site [active]
696281009799	putative catalytic site [active]
696281009800	putative Zn binding site [ion binding]; other site
696281009801	Domain of unknown function (DUF2088); Region: DUF2088; cl15406
696281009802	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
696281009803	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
696281009804	protein binding site [polypeptide binding]; other site
696281009805	Domain of unknown function (DUF3391); Region: DUF3391; pfam11871
696281009806	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
696281009807	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
696281009808	Zn2+ binding site [ion binding]; other site
696281009809	Mg2+ binding site [ion binding]; other site
696281009810	Heterodisulfide reductase, subunit A and related polyferredoxins [Energy production and conversion]; Region: HdrA; COG1148
696281009811	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992
696281009812	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
696281009813	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
696281009814	Methyl-viologen-reducing hydrogenase, delta subunit; Region: FlpD; pfam02662
696281009815	4Fe-4S binding domain; Region: Fer4; pfam00037
696281009816	4Fe-4S dicluster domain; Region: Fer4_10; pfam13237
696281009817	adenylylsulfate reductase subunit alpha; Validated; Region: PRK06854
696281009818	adenosine phosphosulphate reductase, beta subunit; Region: aprB; TIGR02060
696281009819	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
696281009820	Adenosine-5'-phosphosulfate reductase beta subunit; Region: APS-reductase_C; pfam12139
696281009821	sulfate adenylyltransferase; Reviewed; Region: sat; PRK04149
696281009822	ATP-sulfurylase; Region: ATPS; cd00517
696281009823	active site
696281009824	HXXH motif; other site
696281009825	flexible loop; other site
696281009826	Heterodisulfide reductase, subunit B [Energy production and conversion]; Region: HdrB; COG2048
696281009827	Cysteine-rich domain; Region: CCG; pfam02754
696281009828	Cysteine-rich domain; Region: CCG; pfam02754
696281009829	4Fe-4S dicluster domain; Region: Fer4_17; pfam13534
696281009830	Flagellin N-methylase; Region: FliB; pfam03692
696281009831	Protein of unknown function (DUF964); Region: DUF964; pfam06133
696281009832	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
696281009833	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
696281009834	active site
696281009835	phosphorylation site [posttranslational modification]
696281009836	intermolecular recognition site; other site
696281009837	dimerization interface [polypeptide binding]; other site
696281009838	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
696281009839	DNA binding site [nucleotide binding]
696281009840	PilZ domain; Region: PilZ; pfam07238
696281009841	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
696281009842	Major Facilitator Superfamily; Region: MFS_1; pfam07690
696281009843	putative substrate translocation pore; other site
696281009844	Peptidase family U32; Region: Peptidase_U32; pfam01136
696281009845	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
696281009846	Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309
696281009847	ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608
696281009848	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
696281009849	Walker A/P-loop; other site
696281009850	ATP binding site [chemical binding]; other site
696281009851	Q-loop/lid; other site
696281009852	ABC transporter signature motif; other site
696281009853	Walker B; other site
696281009854	D-loop; other site
696281009855	H-loop/switch region; other site
696281009856	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
696281009857	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
696281009858	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
696281009859	Walker A/P-loop; other site
696281009860	ATP binding site [chemical binding]; other site
696281009861	Q-loop/lid; other site
696281009862	ABC transporter signature motif; other site
696281009863	Walker B; other site
696281009864	D-loop; other site
696281009865	H-loop/switch region; other site
696281009866	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
696281009867	D-ala-D-ala transporter subunit; Provisional; Region: PRK09881
696281009868	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
696281009869	dimer interface [polypeptide binding]; other site
696281009870	conserved gate region; other site
696281009871	putative PBP binding loops; other site
696281009872	ABC-ATPase subunit interface; other site
696281009873	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
696281009874	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
696281009875	dimer interface [polypeptide binding]; other site
696281009876	conserved gate region; other site
696281009877	putative PBP binding loops; other site
696281009878	ABC-ATPase subunit interface; other site
696281009879	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
696281009880	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512
696281009881	DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943
696281009882	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
696281009883	non-specific DNA binding site [nucleotide binding]; other site
696281009884	salt bridge; other site
696281009885	sequence-specific DNA binding site [nucleotide binding]; other site
696281009886	Cupin domain; Region: Cupin_2; pfam07883
696281009887	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
696281009888	CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492
696281009889	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683
696281009890	Metal binding protein AcdA.  These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017
696281009891	Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297
696281009892	metal binding site [ion binding]; metal-binding site
696281009893	dihydrolipoamide dehydrogenase; Region: lipoamide_DH; TIGR01350
696281009894	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
696281009895	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
696281009896	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
696281009897	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
696281009898	dimer interface [polypeptide binding]; other site
696281009899	active site
696281009900	glycine-pyridoxal phosphate binding site [chemical binding]; other site
696281009901	folate binding site [chemical binding]; other site
696281009902	Cache domain; Region: Cache_1; pfam02743
696281009903	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
696281009904	dimerization interface [polypeptide binding]; other site
696281009905	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
696281009906	putative active site [active]
696281009907	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
696281009908	heme pocket [chemical binding]; other site
696281009909	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
696281009910	dimer interface [polypeptide binding]; other site
696281009911	phosphorylation site [posttranslational modification]
696281009912	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
696281009913	ATP binding site [chemical binding]; other site
696281009914	Mg2+ binding site [ion binding]; other site
696281009915	G-X-G motif; other site
696281009916	Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388
696281009917	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
696281009918	trimer interface [polypeptide binding]; other site
696281009919	active site
696281009920	spermidine synthase; Provisional; Region: PRK00811
696281009921	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
696281009922	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
696281009923	S-adenosylmethionine binding site [chemical binding]; other site
696281009924	Endonuclease IV [DNA replication, recombination, and repair]; Region: Nfo; COG0648
696281009925	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060
696281009926	DNA interaction; other site
696281009927	Metal-binding active site; metal-binding site
696281009928	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
696281009929	The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493
696281009930	peptide binding site [polypeptide binding]; other site
696281009931	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
696281009932	Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663
696281009933	Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645
696281009934	trimer interface [polypeptide binding]; other site
696281009935	putative metal binding site [ion binding]; other site
696281009936	isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437
696281009937	Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811
696281009938	homotetramer interface [polypeptide binding]; other site
696281009939	FMN binding site [chemical binding]; other site
696281009940	homodimer contacts [polypeptide binding]; other site
696281009941	putative active site [active]
696281009942	putative substrate binding site [chemical binding]; other site
696281009943	Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217
696281009944	Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891
696281009945	G1 box; other site
696281009946	putative GEF interaction site [polypeptide binding]; other site
696281009947	GTP/Mg2+ binding site [chemical binding]; other site
696281009948	Switch I region; other site
696281009949	G2 box; other site
696281009950	G3 box; other site
696281009951	Switch II region; other site
696281009952	G4 box; other site
696281009953	G5 box; other site
696281009954	BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu.  BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691
696281009955	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a highly...; Region: BipA_TypA_C; cd03710
696281009956	Inner membrane protein import complex subunit Tim54; Region: Tim54; pfam11711
696281009957	Predicted membrane protein [Function unknown]; Region: COG1950
696281009958	Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269
696281009959	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
696281009960	[FeFe] hydrogenase, group A; Region: FeFe_hydrog_A; TIGR02512
696281009961	Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906
696281009962	Iron hydrogenase small subunit; Region: Fe_hyd_SSU; pfam02256
696281009963	4Fe-4S dicluster domain; Region: Fer4_11; pfam13247
696281009964	Polysulphide reductase [Energy production and conversion]; Region: COG5557; cl17901
696281009965	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
696281009966	dimerization interface [polypeptide binding]; other site
696281009967	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
696281009968	putative DNA binding site [nucleotide binding]; other site
696281009969	putative Zn2+ binding site [ion binding]; other site
696281009970	Stage II sporulation protein R (spore_II_R); Region: Spore_II_R; pfam09551
696281009971	Streptomyces rubellomurinus FrbC and related proteins, catalytic TIM barrel domain; Region: DRE_TIM_NifV; cd07939
696281009972	active site
696281009973	catalytic residues [active]
696281009974	metal binding site [ion binding]; metal-binding site
696281009975	Iron only nitrogenase protein AnfO (AnfO_nitrog); Region: AnfO_nitrog; pfam09582
696281009976	Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980
696281009977	dimer interface [polypeptide binding]; other site
696281009978	[2Fe-2S] cluster binding site [ion binding]; other site
696281009979	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
696281009980	Radical SAM superfamily; Region: Radical_SAM; pfam04055
696281009981	FeS/SAM binding site; other site
696281009982	The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia.  This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775
696281009983	Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148
696281009984	nitrogenase molybdenum-iron cofactor biosynthesis protein NifE; Region: nifE; TIGR01283
696281009985	The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia.  This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775
696281009986	The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia.  This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775
696281009987	Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148
696281009988	The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia.  This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775
696281009989	nitrogenase molybdenum-iron cofactor biosynthesis protein NifE; Region: nifE; TIGR01283
696281009990	Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347
696281009991	Nitrogen regulatory protein P-II; Region: P-II; smart00938
696281009992	Nitrogen regulatory protein P-II; Region: P-II; cl00412
696281009993	Nitrogen regulatory protein P-II; Region: P-II; smart00938
696281009994	nitrogenase reductase; Reviewed; Region: nifH; PRK13235
696281009995	NifH gene encodes component II (iron protein) of nitrogenase. Nitrogenase is responsible for the biological nitrogen fixation, i.e. reduction of molecular nitrogen to ammonia. NifH consists of two oxygen-sensitive metallosulfur proteins: the...; Region: NifH; cd02040
696281009996	Nucleotide-binding sites [chemical binding]; other site
696281009997	Walker A motif; other site
696281009998	Switch I region of nucleotide binding site; other site
696281009999	Fe4S4 binding sites [ion binding]; other site
696281010000	Switch II region of nucleotide binding site; other site
696281010001	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
696281010002	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
696281010003	putative substrate translocation pore; other site
696281010004	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
696281010005	Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566
696281010006	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
696281010007	HlyD family secretion protein; Region: HlyD_3; pfam13437
696281010008	putative efflux pump membrane fusion protein; Provisional; Region: PRK03598
696281010009	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
696281010010	HlyD family secretion protein; Region: HlyD_3; pfam13437
696281010011	PAS domain S-box; Region: sensory_box; TIGR00229
696281010012	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
696281010013	putative active site [active]
696281010014	heme pocket [chemical binding]; other site
696281010015	PAS domain S-box; Region: sensory_box; TIGR00229
696281010016	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
696281010017	putative active site [active]
696281010018	heme pocket [chemical binding]; other site
696281010019	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
696281010020	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
696281010021	metal binding site [ion binding]; metal-binding site
696281010022	active site
696281010023	I-site; other site
696281010024	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
696281010025	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
696281010026	Zn2+ binding site [ion binding]; other site
696281010027	Mg2+ binding site [ion binding]; other site
696281010028	RDD family; Region: RDD; pfam06271
696281010029	Protein of unknown function (DUF327); Region: DUF327; pfam03885
696281010030	Carbonic anhydrase; Region: Pro_CA; smart00947
696281010031	active site clefts [active]
696281010032	zinc binding site [ion binding]; other site
696281010033	dimer interface [polypeptide binding]; other site
696281010034	integral membrane protein, YjbE family; Region: R_switched_YjbE; TIGR03717
696281010035	FOG: CBS domain [General function prediction only]; Region: COG0517
696281010036	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622
696281010037	Probable zinc-binding domain; Region: zf-trcl; pfam13451
696281010038	CxxC-x17-CxxC domain; Region: cxxc_cxxc_Mbark; TIGR04272
696281010039	Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285
696281010040	MgtC family; Region: MgtC; pfam02308
696281010041	Phosphatidylserine decarboxylase; Region: PS_Dcarbxylase; cl03656
696281010042	amino acid transporter; Region: 2A0306; TIGR00909
696281010043	C-terminus of AA_permease; Region: AA_permease_C; pfam13906
696281010044	This family is most closely related to the oligosaccharide phosphorylase domain family and other unidentified sequences. Oligosaccharide phosphorylase catalyzes the breakdown of oligosaccharides into glucose-1-phosphate units. They are important...; Region: GT1_Glycogen_Phosphorylase_like; cd04299
696281010045	putative homodimer interface [polypeptide binding]; other site
696281010046	putative active site pocket [active]
696281010047	alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094
696281010048	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
696281010049	EamA-like transporter family; Region: EamA; pfam00892
696281010050	EamA-like transporter family; Region: EamA; pfam00892
696281010051	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
696281010052	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
696281010053	putative active site [active]
696281010054	heme pocket [chemical binding]; other site
696281010055	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
696281010056	putative active site [active]
696281010057	heme pocket [chemical binding]; other site
696281010058	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
696281010059	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
696281010060	metal binding site [ion binding]; metal-binding site
696281010061	active site
696281010062	I-site; other site
696281010063	CHASE3 domain; Region: CHASE3; cl05000
696281010064	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
696281010065	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
696281010066	dimerization interface [polypeptide binding]; other site
696281010067	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
696281010068	dimer interface [polypeptide binding]; other site
696281010069	putative CheW interface [polypeptide binding]; other site
696281010070	stage V sporulation protein K; Region: spore_V_K; TIGR02881
696281010071	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
696281010072	Walker A motif; other site
696281010073	ATP binding site [chemical binding]; other site
696281010074	Walker B motif; other site
696281010075	Transcriptional regulators [Transcription]; Region: GntR; COG1802
696281010076	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
696281010077	DNA-binding site [nucleotide binding]; DNA binding site
696281010078	FCD domain; Region: FCD; pfam07729
696281010079	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
696281010080	active site
696281010081	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
696281010082	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
696281010083	active site
696281010084	metal binding site [ion binding]; metal-binding site
696281010085	V-type ATP synthase subunit I; Validated; Region: PRK05771
696281010086	The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cd06462
696281010087	Catalytic site [active]
696281010088	Bacterial Ig-like domain (group 3); Region: Big_3_3; pfam13750
696281010089	Phage-related tail fibre protein [General function prediction only]; Region: COG5301
696281010090	Phage uncharacterized protein (Phage_XkdX); Region: Phage_XkdX; cl09900
696281010091	Uncharacterized protein conserved in bacteria (DUF2313); Region: DUF2313; pfam10076
696281010092	Uncharacterized homolog of phage Mu protein gp47 [Function unknown]; Region: XkdT; COG3299
696281010093	Protein of unknown function (DUF2634); Region: DUF2634; pfam10934
696281010094	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
696281010095	Phage XkdN-like protein; Region: XkdN; pfam08890
696281010096	Protein of unknown function (DUF2001); Region: DUF2001; pfam09393
696281010097	Phage tail sheath protein; Region: Phage_sheath_1; pfam04984
696281010098	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
696281010099	non-specific DNA binding site [nucleotide binding]; other site
696281010100	salt bridge; other site
696281010101	sequence-specific DNA binding site [nucleotide binding]; other site
696281010102	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
696281010103	Catalytic site [active]
696281010104	Transposase domain (DUF772); Region: DUF772; pfam05598
696281010105	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
696281010106	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
696281010107	Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284
696281010108	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
696281010109	putative active site [active]
696281010110	heme pocket [chemical binding]; other site
696281010111	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
696281010112	Walker A motif; other site
696281010113	ATP binding site [chemical binding]; other site
696281010114	Walker B motif; other site
696281010115	arginine finger; other site
696281010116	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
696281010117	putative DNA binding site [nucleotide binding]; other site
696281010118	putative Zn2+ binding site [ion binding]; other site
696281010119	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
696281010120	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
696281010121	NAD(P) binding site [chemical binding]; other site
696281010122	catalytic residues [active]
696281010123	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
696281010124	S-adenosylmethionine binding site [chemical binding]; other site
696281010125	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
696281010126	Alpha/beta hydrolase of unknown function (DUF1057); Region: DUF1057; pfam06342
696281010127	TAP-like protein; Region: Abhydrolase_4; pfam08386
696281010128	Nitrate reductase gamma subunit; Region: Nitrate_red_gam; cl00959
696281010129	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
696281010130	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
696281010131	TIGR03032 family protein; Region: TIGR03032
696281010132	CRISPR-associated protein; Region: TIGR03986
696281010133	CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cd09726
696281010134	CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cd09726
696281010135	CRISPR/Cas system-associated RAMP superfamily protein Csx10; Region: Csx10; cl17558
696281010136	CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cd09726
696281010137	Domain of unknown function (DUF3841); Region: DUF3841; pfam12952
696281010138	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
696281010139	catalytic residues [active]
696281010140	catalytic nucleophile [active]
696281010141	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
696281010142	Recombinase; Region: Recombinase; pfam07508
696281010143	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
696281010144	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
696281010145	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
696281010146	catalytic residues [active]
696281010147	catalytic nucleophile [active]
696281010148	Recombinase; Region: Recombinase; pfam07508
696281010149	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
696281010150	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
696281010151	DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595
696281010152	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
696281010153	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
696281010154	active site
696281010155	metal binding site [ion binding]; metal-binding site
696281010156	Holin family; Region: Phage_holin_4; pfam05105
696281010157	Phage late control gene D protein (GPD); Region: Phage_GPD; cl15796
696281010158	Phage-related protein [Function unknown]; Region: COG5412
696281010159	Protein of unknown function (DUF3584); Region: DUF3584; pfam12128
696281010160	phage major tail protein, phi13 family; Region: maj_tail_phi13; TIGR01603
696281010161	Bacterial Ig-like domain; Region: Big_5; pfam13205
696281010162	Domain of unknown function (DUF1968); Region: DUF1968; pfam09291
696281010163	phage protein, HK97 gp10 family; Region: phge_HK97_gp10; TIGR01725
696281010164	Phage head-tail joining protein; Region: Phage_H_T_join; pfam05521
696281010165	Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054
696281010166	oligomerization interface [polypeptide binding]; other site
696281010167	phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554
696281010168	Phage capsid family; Region: Phage_capsid; pfam05065
696281010169	Clp protease; Region: CLP_protease; pfam00574
696281010170	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016
696281010171	oligomer interface [polypeptide binding]; other site
696281010172	active site residues [active]
696281010173	Phage-related protein [Function unknown]; Region: COG4695
696281010174	Phage portal protein; Region: Phage_portal; pfam04860
696281010175	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
696281010176	Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626
696281010177	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661
696281010178	putative active site pocket [active]
696281010179	dimerization interface [polypeptide binding]; other site
696281010180	putative catalytic residue [active]
696281010181	Putative amidoligase enzyme; Region: Amidoligase_2; pfam12224
696281010182	Domain of unknown function (DUF4314); Region: DUF4314; pfam14192
696281010183	Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475
696281010184	ParB-like nuclease domain; Region: ParBc; pfam02195
696281010185	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
696281010186	DNA methylase; Region: N6_N4_Mtase; pfam01555
696281010187	Phage terminase, small subunit; Region: Terminase_4; cl01525
696281010188	SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966
696281010189	YwpF-like protein; Region: YwpF; pfam14183
696281010190	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
696281010191	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
696281010192	active site
696281010193	Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553
696281010194	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
696281010195	ATP binding site [chemical binding]; other site
696281010196	putative Mg++ binding site [ion binding]; other site
696281010197	VRR-NUC domain; Region: VRR_NUC; pfam08774
696281010198	Virulence-associated protein E; Region: VirE; pfam05272
696281010199	Prophage antirepressor [Transcription]; Region: COG3617
696281010200	BRO family, N-terminal domain; Region: Bro-N; smart01040
696281010201	Uncharacterized phage-encoded protein [Function unknown]; Region: COG3645
696281010202	DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012
696281010203	active site
696281010204	substrate binding site [chemical binding]; other site
696281010205	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_A; cd08642
696281010206	active site
696281010207	DNA binding site [nucleotide binding]
696281010208	catalytic site [active]
696281010209	NUMOD4 motif; Region: NUMOD4; pfam07463
696281010210	HNH endonuclease; Region: HNH_3; pfam13392
696281010211	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393
696281010212	DNA-binding interface [nucleotide binding]; DNA binding site
696281010213	Protein of unknown function (DUF2815); Region: DUF2815; pfam10991
696281010214	Protein of unknown function (DUF2800); Region: DUF2800; pfam10926
696281010215	DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595
696281010216	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
696281010217	DNA binding residues [nucleotide binding]
696281010218	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
696281010219	AAA domain; Region: AAA_23; pfam13476
696281010220	Walker A/P-loop; other site
696281010221	ATP binding site [chemical binding]; other site
696281010222	DNA binding domain, excisionase family; Region: excise; TIGR01764
696281010223	HsdM N-terminal domain; Region: HsdM_N; pfam12161
696281010224	N-6 DNA Methylase; Region: N6_Mtase; pfam02384
696281010225	Methyltransferase domain; Region: Methyltransf_26; pfam13659
696281010226	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
696281010227	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
696281010228	tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224
696281010229	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
696281010230	active site
696281010231	DNA binding site [nucleotide binding]
696281010232	Int/Topo IB signature motif; other site
696281010233	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
696281010234	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
696281010235	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
696281010236	Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610
696281010237	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313
696281010238	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
696281010239	ATP binding site [chemical binding]; other site
696281010240	putative Mg++ binding site [ion binding]; other site
696281010241	Domain of unknown function (DUF3387); Region: DUF3387; pfam11867
696281010242	Uncharacterized conserved protein [Function unknown]; Region: COG1479
696281010243	Protein of unknown function DUF262; Region: DUF262; pfam03235
696281010244	Protein of unknown function (DUF1524); Region: DUF1524; pfam07510
696281010245	Uncharacterized conserved protein [Function unknown]; Region: COG3586
696281010246	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
696281010247	SmpB-tmRNA interface; other site
696281010248	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
696281010249	Zn2+ binding site [ion binding]; other site
696281010250	Mg2+ binding site [ion binding]; other site
696281010251	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
696281010252	CoenzymeA binding site [chemical binding]; other site
696281010253	subunit interaction site [polypeptide binding]; other site
696281010254	PHB binding site; other site
696281010255	Inorganic H+ pyrophosphatase; Region: H_PPase; pfam03030
696281010256	H(+) -translocating inorganic pyrophosphatase; Region: PLN02255; cl11452
696281010257	enolase; Provisional; Region: eno; PRK00077
696281010258	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
696281010259	dimer interface [polypeptide binding]; other site
696281010260	metal binding site [ion binding]; metal-binding site
696281010261	substrate binding pocket [chemical binding]; other site
696281010262	phosphoglyceromutase; Provisional; Region: PRK05434
696281010263	Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696
696281010264	triosephosphate isomerase; Provisional; Region: PRK14565
696281010265	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
696281010266	substrate binding site [chemical binding]; other site
696281010267	dimer interface [polypeptide binding]; other site
696281010268	catalytic triad [active]
696281010269	Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318
696281010270	Phosphoglycerate kinase; Region: PGK; pfam00162
696281010271	substrate binding site [chemical binding]; other site
696281010272	hinge regions; other site
696281010273	ADP binding site [chemical binding]; other site
696281010274	catalytic site [active]
696281010275	Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057
696281010276	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
696281010277	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
696281010278	RNA polymerase factor sigma-54; Reviewed; Region: PRK05932
696281010279	Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309
696281010280	Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963
696281010281	Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552
696281010282	DNA repair protein endonuclease SAE2/CtIP C-terminus; Region: SAE2; pfam08573
696281010283	Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706
696281010284	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481
696281010285	Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298
696281010286	Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298
696281010287	Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918
696281010288	putative active site [active]
696281010289	putative metal binding site [ion binding]; other site
696281010290	conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826
696281010291	family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187
696281010292	phosphate binding site [ion binding]; other site
696281010293	putative substrate binding pocket [chemical binding]; other site
696281010294	dimer interface [polypeptide binding]; other site
696281010295	glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416
696281010296	AAA domain; Region: AAA_18; pfam13238
696281010297	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
696281010298	regulatory protein interface [polypeptide binding]; other site
696281010299	active site
696281010300	regulatory phosphorylation site [posttranslational modification]; other site
696281010301	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
696281010302	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
696281010303	active site
696281010304	motif I; other site
696281010305	motif II; other site
696281010306	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
696281010307	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
696281010308	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
696281010309	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
696281010310	GIY-YIG motif/motif A; other site
696281010311	active site
696281010312	catalytic site [active]
696281010313	putative DNA binding site [nucleotide binding]; other site
696281010314	metal binding site [ion binding]; metal-binding site
696281010315	UvrB/uvrC motif; Region: UVR; pfam02151
696281010316	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
696281010317	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
696281010318	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
696281010319	putative efflux pump membrane fusion protein; Provisional; Region: PRK03598
696281010320	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
696281010321	HlyD family secretion protein; Region: HlyD_3; pfam13437
696281010322	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
696281010323	putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608
696281010324	Walker A/P-loop; other site
696281010325	ATP binding site [chemical binding]; other site
696281010326	Q-loop/lid; other site
696281010327	ABC transporter signature motif; other site
696281010328	Walker B; other site
696281010329	D-loop; other site
696281010330	H-loop/switch region; other site
696281010331	ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698
696281010332	ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698
696281010333	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
696281010334	YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061
696281010335	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
696281010336	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
696281010337	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
696281010338	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
696281010339	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
696281010340	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
696281010341	excinuclease ABC subunit B; Provisional; Region: PRK05298
696281010342	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
696281010343	ATP binding site [chemical binding]; other site
696281010344	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
696281010345	nucleotide binding region [chemical binding]; other site
696281010346	ATP-binding site [chemical binding]; other site
696281010347	Ultra-violet resistance protein B; Region: UvrB; pfam12344
696281010348	UvrB/uvrC motif; Region: UVR; pfam02151
696281010349	Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030
696281010350	Fe-S cluster binding site [ion binding]; other site
696281010351	active site
696281010352	Protein of unknown function (DUF3243); Region: DUF3243; pfam11588
696281010353	Predicted RNA-binding protein; Region: RNA_bind_2; pfam10133
696281010354	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
696281010355	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
696281010356	C-terminal peptidase (prc); Region: prc; TIGR00225
696281010357	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
696281010358	protein binding site [polypeptide binding]; other site
696281010359	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
696281010360	Catalytic dyad [active]
696281010361	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883
696281010362	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
696281010363	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
696281010364	Peptidase family M23; Region: Peptidase_M23; pfam01551
696281010365	Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177
696281010366	cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026
696281010367	Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884
696281010368	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
696281010369	Walker A/P-loop; other site
696281010370	ATP binding site [chemical binding]; other site
696281010371	Q-loop/lid; other site
696281010372	ABC transporter signature motif; other site
696281010373	Walker B; other site
696281010374	D-loop; other site
696281010375	H-loop/switch region; other site
696281010376	Predicted O-acyltransferase [General function prediction only]; Region: COG3274
696281010377	Acyltransferase family; Region: Acyl_transf_3; pfam01757
696281010378	Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958
696281010379	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
696281010380	PYR/PP interface [polypeptide binding]; other site
696281010381	dimer interface [polypeptide binding]; other site
696281010382	TPP binding site [chemical binding]; other site
696281010383	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
696281010384	transketolase; Reviewed; Region: PRK05899
696281010385	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
696281010386	TPP-binding site [chemical binding]; other site
696281010387	dimer interface [polypeptide binding]; other site
696281010388	Uncharacterized conserved protein [Function unknown]; Region: COG1284
696281010389	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
696281010390	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
696281010391	peptide chain release factor 2; Validated; Region: prfB; PRK00578
696281010392	This domain is found in peptide chain release factors; Region: PCRF; smart00937
696281010393	RF-1 domain; Region: RF-1; pfam00472
696281010394	preprotein translocase subunit SecA; Reviewed; Region: PRK12904
696281010395	DEAD/DEAH box helicase; Region: DEAD; pfam00270
696281010396	ATP binding site [chemical binding]; other site
696281010397	putative Mg++ binding site [ion binding]; other site
696281010398	SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958
696281010399	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
696281010400	30S subunit binding site; other site
696281010401	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
696281010402	DNA-binding site [nucleotide binding]; DNA binding site
696281010403	RNA-binding motif; other site
696281010404	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
696281010405	PAS domain; Region: PAS_9; pfam13426
696281010406	putative active site [active]
696281010407	heme pocket [chemical binding]; other site
696281010408	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
696281010409	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
696281010410	metal binding site [ion binding]; metal-binding site
696281010411	active site
696281010412	I-site; other site
696281010413	Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040
696281010414	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
696281010415	active site
696281010416	Protein of unknown function (DUF2922); Region: DUF2922; pfam11148
696281010417	Protein of unknown function (DUF1659); Region: DUF1659; pfam07872
696281010418	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
696281010419	GAF domain; Region: GAF_3; pfam13492
696281010420	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
696281010421	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
696281010422	metal binding site [ion binding]; metal-binding site
696281010423	active site
696281010424	I-site; other site
696281010425	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
696281010426	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
696281010427	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
696281010428	dimer interface [polypeptide binding]; other site
696281010429	phosphorylation site [posttranslational modification]
696281010430	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
696281010431	ATP binding site [chemical binding]; other site
696281010432	Mg2+ binding site [ion binding]; other site
696281010433	G-X-G motif; other site
696281010434	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
696281010435	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
696281010436	non-specific DNA binding site [nucleotide binding]; other site
696281010437	salt bridge; other site
696281010438	sequence-specific DNA binding site [nucleotide binding]; other site
696281010439	S-adenosylmethionine synthetase; Validated; Region: PRK05250
696281010440	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
696281010441	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
696281010442	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
696281010443	sporulation protein, YlmC/YmxH family; Region: spore_YlmC_YmxH; TIGR02888
696281010444	integral membrane protein MviN; Region: mviN; TIGR01695
696281010445	MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123
696281010446	Peptidase S8 family domain in Kp43 proteases; Region: Peptidases_S8_Kp43_protease; cd04842
696281010447	active site
696281010448	catalytic triad [active]
696281010449	S-layer homology domain; Region: SLH; pfam00395
696281010450	S-layer homology domain; Region: SLH; pfam00395
696281010451	S-layer homology domain; Region: SLH; pfam00395
696281010452	Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109
696281010453	This PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily and is found in both archaea and bacteria. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible...; Region: PGM_like2; cd05800
696281010454	active site
696281010455	substrate binding site [chemical binding]; other site
696281010456	metal binding site [ion binding]; metal-binding site
696281010457	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
696281010458	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
696281010459	NAD(P) binding site [chemical binding]; other site
696281010460	active site
696281010461	Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
696281010462	dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209
696281010463	active site
696281010464	tetramer interface; other site
696281010465	UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472
696281010466	This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853
696281010467	Mg++ binding site [ion binding]; other site
696281010468	putative catalytic motif [active]
696281010469	substrate binding site [chemical binding]; other site
696281010470	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
696281010471	FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831
696281010472	Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992
696281010473	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
696281010474	Polysaccharide pyruvyl transferase family protein [Cell wall/membrane/envelope biogenesis]; Region: WcaK; COG2327
696281010475	polysaccharide pyruvyl transferase CsaB; Region: S_layer_CsaB; TIGR03609
696281010476	FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831
696281010477	Transcriptional regulator [Transcription]; Region: LytR; COG1316
696281010478	Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922
696281010479	The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533
696281010480	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604
696281010481	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
696281010482	active site
696281010483	catalytic triad [active]
696281010484	oxyanion hole [active]
696281010485	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
696281010486	Beta-mannanase [Carbohydrate transport and metabolism]; Region: ManB; COG4124
696281010487	DHHW protein; Region: DHHW; pfam14286
696281010488	Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696
696281010489	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
696281010490	S-adenosylmethionine binding site [chemical binding]; other site
696281010491	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
696281010492	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
696281010493	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
696281010494	Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692
696281010495	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
696281010496	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
696281010497	Methyltransferase domain; Region: Methyltransf_23; pfam13489
696281010498	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
696281010499	S-adenosylmethionine binding site [chemical binding]; other site
696281010500	ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134
696281010501	ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220
696281010502	Walker A/P-loop; other site
696281010503	ATP binding site [chemical binding]; other site
696281010504	Q-loop/lid; other site
696281010505	ABC transporter signature motif; other site
696281010506	Walker B; other site
696281010507	D-loop; other site
696281010508	H-loop/switch region; other site
696281010509	C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147
696281010510	putative carbohydrate binding site [chemical binding]; other site
696281010511	ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682
696281010512	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
696281010513	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
696281010514	This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809
696281010515	The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089
696281010516	phosphomannomutase CpsG; Provisional; Region: PRK15414
696281010517	active site
696281010518	substrate binding site [chemical binding]; other site
696281010519	metal binding site [ion binding]; metal-binding site
696281010520	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
696281010521	This family is most closely related to the GT1 family of glycosyltransferases.  wbaZ in Salmonella enterica has been shown to possess the mannosyl transferase activity. The members of this family are found in certain bacteria and Archaea; Region: GT1_wbaZ_like; cd03804
696281010522	putative ADP-binding pocket [chemical binding]; other site
696281010523	mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479
696281010524	GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509
696281010525	Substrate binding site; other site
696281010526	Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050
696281010527	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
696281010528	GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260
696281010529	NADP-binding site; other site
696281010530	homotetramer interface [polypeptide binding]; other site
696281010531	substrate binding site [chemical binding]; other site
696281010532	homodimer interface [polypeptide binding]; other site
696281010533	active site
696281010534	GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089
696281010535	GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260
696281010536	NADP-binding site; other site
696281010537	homotetramer interface [polypeptide binding]; other site
696281010538	substrate binding site [chemical binding]; other site
696281010539	homodimer interface [polypeptide binding]; other site
696281010540	active site
696281010541	exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025
696281010542	NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226
696281010543	NAD(P) binding pocket [chemical binding]; other site
696281010544	Bacterial sugar transferase; Region: Bac_transf; pfam02397
696281010545	O-Antigen ligase; Region: Wzy_C; cl04850
696281010546	O-Antigen ligase; Region: Wzy_C; pfam04932
696281010547	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
696281010548	TPR motif; other site
696281010549	binding surface
696281010550	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
696281010551	Outer membrane efflux protein; Region: OEP; pfam02321
696281010552	Outer membrane efflux protein; Region: OEP; pfam02321
696281010553	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
696281010554	rod shape-determining protein Mbl; Provisional; Region: PRK13928
696281010555	MreB and similar proteins; Region: MreB_like; cd10225
696281010556	nucleotide binding site [chemical binding]; other site
696281010557	Mg binding site [ion binding]; other site
696281010558	putative protofilament interaction site [polypeptide binding]; other site
696281010559	RodZ interaction site [polypeptide binding]; other site
696281010560	Stage III sporulation protein D; Region: SpoIIID; pfam12116
696281010561	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
696281010562	Peptidase family M23; Region: Peptidase_M23; pfam01551
696281010563	Stage II sporulation protein; Region: SpoIID; pfam08486
696281010564	SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669
696281010565	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
696281010566	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
696281010567	hinge; other site
696281010568	active site
696281010569	F0F1 ATP synthase subunit epsilon; Provisional; Region: atpC; PRK13446
696281010570	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
696281010571	gamma subunit interface [polypeptide binding]; other site
696281010572	epsilon subunit interface [polypeptide binding]; other site
696281010573	LBP interface [polypeptide binding]; other site
696281010574	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
696281010575	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
696281010576	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
696281010577	alpha subunit interaction interface [polypeptide binding]; other site
696281010578	Walker A motif; other site
696281010579	ATP binding site [chemical binding]; other site
696281010580	Walker B motif; other site
696281010581	inhibitor binding site; inhibition site
696281010582	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
696281010583	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
696281010584	core domain interface [polypeptide binding]; other site
696281010585	delta subunit interface [polypeptide binding]; other site
696281010586	epsilon subunit interface [polypeptide binding]; other site
696281010587	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
696281010588	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
696281010589	F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
696281010590	beta subunit interaction interface [polypeptide binding]; other site
696281010591	Walker A motif; other site
696281010592	ATP binding site [chemical binding]; other site
696281010593	Walker B motif; other site
696281010594	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
696281010595	F0F1 ATP synthase subunit delta; Provisional; Region: PRK13429
696281010596	F0F1 ATP synthase subunit delta; Validated; Region: PRK05758
696281010597	F0F1 ATP synthase subunit B; Validated; Region: PRK05759
696281010598	F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711
696281010599	F0F1 ATP synthase subunit C; Validated; Region: PRK06876
696281010600	F0F1 ATP synthase subunit A; Validated; Region: PRK05815
696281010601	F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356
696281010602	ATP synthase I chain; Region: ATP_synt_I; pfam03899
696281010603	Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; pfam09527
696281010604	UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381
696281010605	Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase  family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786
696281010606	active site
696281010607	homodimer interface [polypeptide binding]; other site
696281010608	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in uncharacterized protein from Archaeoglobus fulgidus (Af0060) and its bacterial homologs; Region: NTP-PPase_Af0060_like; cd11533
696281010609	homodimer interface [polypeptide binding]; other site
696281010610	metal binding site [ion binding]; metal-binding site
696281010611	Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286
696281010612	catalytic motif [active]
696281010613	Zn binding site [ion binding]; other site
696281010614	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
696281010615	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
696281010616	dimer interface [polypeptide binding]; other site
696281010617	active site
696281010618	glycine-pyridoxal phosphate binding site [chemical binding]; other site
696281010619	folate binding site [chemical binding]; other site
696281010620	Ribose/Galactose Isomerase; Region: LacAB_rpiB; pfam02502
696281010621	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
696281010622	Low molecular weight phosphatase family; Region: LMWPc; cd00115
696281010623	active site
696281010624	Predicted membrane protein [Function unknown]; Region: COG1971
696281010625	Domain of unknown function DUF; Region: DUF204; pfam02659
696281010626	Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009
696281010627	Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481
696281010628	N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328
696281010629	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
696281010630	S-adenosylmethionine binding site [chemical binding]; other site
696281010631	peptide chain release factor 1; Validated; Region: prfA; PRK00591
696281010632	This domain is found in peptide chain release factors; Region: PCRF; smart00937
696281010633	RF-1 domain; Region: RF-1; pfam00472
696281010634	Protein of unknown function (DUF1385); Region: DUF1385; pfam07136
696281010635	50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019
696281010636	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
696281010637	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
696281010638	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
696281010639	Peptidase family M23; Region: Peptidase_M23; pfam01551
696281010640	transcription termination factor Rho; Provisional; Region: rho; PRK09376
696281010641	Rho termination factor, N-terminal domain; Region: Rho_N; smart00959
696281010642	Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459
696281010643	RNA binding site [nucleotide binding]; other site
696281010644	Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128
696281010645	multimer interface [polypeptide binding]; other site
696281010646	Walker A motif; other site
696281010647	ATP binding site [chemical binding]; other site
696281010648	Walker B motif; other site
696281010649	Uncharacterized protein conserved in bacteria (DUF2062); Region: DUF2062; pfam09835
696281010650	Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956
696281010651	active site
696281010652	intersubunit interactions; other site
696281010653	catalytic residue [active]
696281010654	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
696281010655	intersubunit interface [polypeptide binding]; other site
696281010656	active site
696281010657	zinc binding site [ion binding]; other site
696281010658	Na+ binding site [ion binding]; other site
696281010659	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
696281010660	Response regulator receiver domain; Region: Response_reg; pfam00072
696281010661	active site
696281010662	phosphorylation site [posttranslational modification]
696281010663	intermolecular recognition site; other site
696281010664	dimerization interface [polypeptide binding]; other site
696281010665	Yip1 domain; Region: Yip1; pfam04893
696281010666	signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706
696281010667	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
696281010668	tandem repeat interface [polypeptide binding]; other site
696281010669	oligomer interface [polypeptide binding]; other site
696281010670	active site residues [active]
696281010671	CTP synthetase; Validated; Region: pyrG; PRK05380
696281010672	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
696281010673	Catalytic site [active]
696281010674	active site
696281010675	UTP binding site [chemical binding]; other site
696281010676	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
696281010677	active site
696281010678	putative oxyanion hole; other site
696281010679	catalytic triad [active]
696281010680	Protein of unknown function (DUF1427); Region: DUF1427; cl01771
696281010681	arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611
696281010682	Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016
696281010683	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
696281010684	active site
696281010685	HIGH motif; other site
696281010686	KMSK motif region; other site
696281010687	Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956
696281010688	tRNA binding surface [nucleotide binding]; other site
696281010689	anticodon binding site; other site
696281010690	Domain of unknown function (DUF1934); Region: DUF1934; pfam09148
696281010691	Adenosine deaminase z-alpha domain; Region: z-alpha; cl02659
696281010692	sulfite reductase, dissimilatory-type beta subunit; Region: dsrB; TIGR02066
696281010693	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
696281010694	sulfite reductase, dissimilatory-type alpha subunit; Region: dsrA; TIGR02064
696281010695	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
696281010696	Immunity protein Imm6; Region: Imm6; pfam14434
696281010697	indolepyruvate oxidoreductase subunit beta; Reviewed; Region: PRK06853
696281010698	2-oxoglutarate ferredoxin oxidoreductase subunit gamma; Validated; Region: PRK08537
696281010699	indolepyruvate ferredoxin oxidoreductase, alpha subunit; Region: IOR_alpha; TIGR03336
696281010700	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
696281010701	dimer interface [polypeptide binding]; other site
696281010702	PYR/PP interface [polypeptide binding]; other site
696281010703	TPP binding site [chemical binding]; other site
696281010704	substrate binding site [chemical binding]; other site
696281010705	Thiamine pyrophosphate (TPP) family, IOR-alpha subfamily, TPP-binding module; composed of proteins similar to indolepyruvate ferredoxin oxidoreductase (IOR) alpha subunit. IOR catalyzes the oxidative decarboxylation of arylpyruvates, such as...; Region: TPP_IOR_alpha; cd02008
696281010706	TPP-binding site; other site
696281010707	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
696281010708	Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541
696281010709	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
696281010710	acyl-activating enzyme (AAE) consensus motif; other site
696281010711	AMP binding site [chemical binding]; other site
696281010712	active site
696281010713	CoA binding site [chemical binding]; other site
696281010714	hypothetical protein; Validated; Region: PRK07682
696281010715	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
696281010716	pyridoxal 5'-phosphate binding site [chemical binding]; other site
696281010717	homodimer interface [polypeptide binding]; other site
696281010718	catalytic residue [active]
696281010719	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
696281010720	Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412
696281010721	AsnC family; Region: AsnC_trans_reg; pfam01037
696281010722	germination protein YpeB; Region: spore_YpeB; TIGR02889
696281010723	spore cortex-lytic enzyme; Region: spore_SleB; TIGR02869
696281010724	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
696281010725	Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486
696281010726	cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077
696281010727	dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090
696281010728	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130
696281010729	catalytic triad [active]
696281010730	Dissimilatory sulfite reductase (desulfoviridin), gamma subunit [Inorganic ion transport and metabolism]; Region: DsrC; COG2920
696281010731	DsrC like protein; Region: DsrC; pfam04358
696281010732	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
696281010733	Cysteine-rich domain; Region: CCG; pfam02754
696281010734	Nitrate reductase gamma subunit; Region: Nitrate_red_gam; cl00959
696281010735	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
696281010736	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
696281010737	Protein of unknown function (DUF964); Region: DUF964; pfam06133
696281010738	A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194
696281010739	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
696281010740	minor groove reading motif; other site
696281010741	helix-hairpin-helix signature motif; other site
696281010742	substrate binding pocket [chemical binding]; other site
696281010743	active site
696281010744	iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525
696281010745	DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread  A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431
696281010746	DNA binding and oxoG recognition site [nucleotide binding]
696281010747	competence damage-inducible protein A; Provisional; Region: PRK00549
696281010748	Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885
696281010749	putative MPT binding site; other site
696281010750	Competence-damaged protein; Region: CinA; pfam02464
696281010751	Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309
696281010752	Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073
696281010753	ornithine--oxo-acid transaminase; Provisional; Region: rocD; PRK04073
696281010754	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
696281010755	inhibitor-cofactor binding pocket; inhibition site
696281010756	pyridoxal 5'-phosphate binding site [chemical binding]; other site
696281010757	catalytic residue [active]
696281010758	Ribosomal protein S1 [Translation, ribosomal structure and biogenesis]; Region: RpsA; COG0539
696281010759	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
696281010760	RNA binding site [nucleotide binding]; other site
696281010761	ParB-like nuclease domain; Region: ParB; smart00470
696281010762	Violaxanthin de-epoxidase (VDE); Region: VDE; cl06253
696281010763	TraM recognition site of TraD and TraG; Region: TraG-D_C; cl17375
696281010764	AAA-like domain; Region: AAA_10; pfam12846
696281010765	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
696281010766	Walker A motif; other site
696281010767	ATP binding site [chemical binding]; other site
696281010768	Walker B motif; other site
696281010769	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
696281010770	Zn2+ binding site [ion binding]; other site
696281010771	Mg2+ binding site [ion binding]; other site
696281010772	Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227
696281010773	PRTRC system protein D; Region: PRTRC_D; TIGR03739
696281010774	Mg binding site [ion binding]; other site
696281010775	nucleotide binding site [chemical binding]; other site
696281010776	putative protofilament interface [polypeptide binding]; other site
696281010777	VanW like protein; Region: VanW; pfam04294
696281010778	Protein of unknown function (DUF1439); Region: DUF1439; cl06345
696281010779	site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236
696281010780	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
696281010781	active site
696281010782	DNA binding site [nucleotide binding]
696281010783	Int/Topo IB signature motif; other site
696281010784	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
696281010785	Ligand binding site; other site
696281010786	Putative Catalytic site; other site
696281010787	DXD motif; other site
696281010788	4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnF; Provisional; Region: PRK02971
696281010789	TadE-like protein; Region: TadE; pfam07811
696281010790	Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989
696281010791	Type IV leader peptidase family; Region: Peptidase_A24; pfam01478
696281010792	Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965
696281010793	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
696281010794	Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965
696281010795	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
696281010796	Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962
696281010797	Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130
696281010798	Walker A motif; other site
696281010799	hexamer interface [polypeptide binding]; other site
696281010800	ATP binding site [chemical binding]; other site
696281010801	Walker B motif; other site
696281010802	AAA domain; Region: AAA_31; pfam13614
696281010803	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
696281010804	Flp pilus assembly protein CpaB [Intracellular trafficking and secretion]; Region: CpaB; COG3745
696281010805	SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614
696281010806	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
696281010807	Fic family protein [Function unknown]; Region: COG3177
696281010808	Fic/DOC family; Region: Fic; pfam02661
696281010809	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
696281010810	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
696281010811	Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877
696281010812	Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929
696281010813	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
696281010814	oligomeric interface; other site
696281010815	putative active site [active]
696281010816	homodimer interface [polypeptide binding]; other site
696281010817	Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002
696281010818	SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966
696281010819	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
696281010820	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
696281010821	metal binding site [ion binding]; metal-binding site
696281010822	active site
696281010823	I-site; other site
696281010824	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
696281010825	B12 binding site [chemical binding]; other site
696281010826	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
696281010827	CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656
696281010828	Lysozyme family protein [General function prediction only]; Region: COG5526
696281010829	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
696281010830	N-acetyl-D-glucosamine binding site [chemical binding]; other site
696281010831	catalytic residue [active]
696281010832	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
696281010833	Peptidase family M23; Region: Peptidase_M23; pfam01551
696281010834	Domain of unknown function DUF87; Region: DUF87; pfam01935
696281010835	AAA-like domain; Region: AAA_10; pfam12846
696281010836	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
696281010837	Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388
696281010838	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
696281010839	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
696281010840	non-specific DNA binding site [nucleotide binding]; other site
696281010841	salt bridge; other site
696281010842	sequence-specific DNA binding site [nucleotide binding]; other site
696281010843	Domain of unknown function (DUF955); Region: DUF955; pfam06114
696281010844	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
696281010845	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
696281010846	active site
696281010847	phosphorylation site [posttranslational modification]
696281010848	intermolecular recognition site; other site
696281010849	dimerization interface [polypeptide binding]; other site
696281010850	LytTr DNA-binding domain; Region: LytTR; pfam04397
696281010851	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
696281010852	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
696281010853	Esterase/lipase [General function prediction only]; Region: COG1647
696281010854	BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840
696281010855	Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509
696281010856	putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834
696281010857	Coat F domain; Region: Coat_F; pfam07875
696281010858	Flagellin N-methylase; Region: FliB; cl00497
696281010859	Arginase family; Region: Arginase; cd09989
696281010860	agmatinase; Region: agmatinase; TIGR01230
696281010861	active site
696281010862	Mn binding site [ion binding]; other site
696281010863	oligomer interface [polypeptide binding]; other site
696281010864	PilZ domain; Region: PilZ; pfam07238
696281010865	methionine sulfoxide reductase B; Provisional; Region: PRK00222
696281010866	SelR domain; Region: SelR; pfam01641
696281010867	methionine sulfoxide reductase A; Provisional; Region: PRK14054
696281010868	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
696281010869	dimerization interface [polypeptide binding]; other site
696281010870	PAS fold; Region: PAS_4; pfam08448
696281010871	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
696281010872	putative active site [active]
696281010873	heme pocket [chemical binding]; other site
696281010874	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
696281010875	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
696281010876	metal binding site [ion binding]; metal-binding site
696281010877	active site
696281010878	I-site; other site
696281010879	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
696281010880	Protein of unknown function (DUF401); Region: DUF401; cl00830
696281010881	Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283
696281010882	Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
696281010883	Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
696281010884	PhoU domain; Region: PhoU; pfam01895
696281010885	PhoU domain; Region: PhoU; pfam01895
696281010886	DNA topoisomerase III; Provisional; Region: PRK07726
696281010887	TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362
696281010888	active site
696281010889	putative interdomain interaction site [polypeptide binding]; other site
696281010890	putative metal-binding site [ion binding]; other site
696281010891	putative nucleotide binding site [chemical binding]; other site
696281010892	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
696281010893	domain I; other site
696281010894	DNA binding groove [nucleotide binding]
696281010895	phosphate binding site [ion binding]; other site
696281010896	domain II; other site
696281010897	domain III; other site
696281010898	nucleotide binding site [chemical binding]; other site
696281010899	catalytic site [active]
696281010900	domain IV; other site
696281010901	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
696281010902	FAD binding domain; Region: FAD_binding_4; pfam01565
696281010903	Berberine and berberine like; Region: BBE; pfam08031
696281010904	Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105
696281010905	1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164
696281010906	putative substrate binding site [chemical binding]; other site
696281010907	putative ATP binding site [chemical binding]; other site
696281010908	fructose-bisphosphate aldolase; Provisional; Region: PRK09197
696281010909	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
696281010910	intersubunit interface [polypeptide binding]; other site
696281010911	active site
696281010912	zinc binding site [ion binding]; other site
696281010913	Na+ binding site [ion binding]; other site
696281010914	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
696281010915	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
696281010916	substrate binding site [chemical binding]; other site
696281010917	ATP binding site [chemical binding]; other site
696281010918	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
696281010919	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
696281010920	TM-ABC transporter signature motif; other site
696281010921	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
696281010922	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
696281010923	Walker A/P-loop; other site
696281010924	ATP binding site [chemical binding]; other site
696281010925	Q-loop/lid; other site
696281010926	ABC transporter signature motif; other site
696281010927	Walker B; other site
696281010928	D-loop; other site
696281010929	H-loop/switch region; other site
696281010930	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
696281010931	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879
696281010932	Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_12; cd06322
696281010933	putative ligand binding site [chemical binding]; other site
696281010934	Transcriptional regulators [Transcription]; Region: PurR; COG1609
696281010935	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
696281010936	DNA binding site [nucleotide binding]
696281010937	domain linker motif; other site
696281010938	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
696281010939	ligand binding site [chemical binding]; other site
696281010940	dimerization interface [polypeptide binding]; other site
696281010941	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
696281010942	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
696281010943	active site
696281010944	metal binding site [ion binding]; metal-binding site
696281010945	2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563
696281010946	5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694
696281010947	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
696281010948	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
696281010949	metal binding site [ion binding]; metal-binding site
696281010950	active site
696281010951	I-site; other site
696281010952	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
696281010953	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
696281010954	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
696281010955	DNA binding residues [nucleotide binding]
696281010956	dimerization interface [polypeptide binding]; other site
696281010957	integral membrane protein, YjbE family; Region: R_switched_YjbE; TIGR03717
696281010958	Tripartite tricarboxylate transporter TctA family; Region: TctA; cl00772
696281010959	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181
696281010960	Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331
696281010961	sulfoacetaldehyde acetyltransferase; Validated; Region: PRK07525
696281010962	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
696281010963	PYR/PP interface [polypeptide binding]; other site
696281010964	dimer interface [polypeptide binding]; other site
696281010965	TPP binding site [chemical binding]; other site
696281010966	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
696281010967	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629
696281010968	TPP-binding site [chemical binding]; other site
696281010969	Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122
696281010970	NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012
696281010971	putative catalytic cysteine [active]
696281010972	succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696
696281010973	ATP-grasp domain; Region: ATP-grasp_2; pfam08442
696281010974	CoA-ligase; Region: Ligase_CoA; pfam00549
696281010975	succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678
696281010976	CoA binding domain; Region: CoA_binding; smart00881
696281010977	CoA-ligase; Region: Ligase_CoA; pfam00549
696281010978	CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588
696281010979	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
696281010980	DNA-binding site [nucleotide binding]; DNA binding site
696281010981	RNA-binding motif; other site
696281010982	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
696281010983	HAMP domain; Region: HAMP; pfam00672
696281010984	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
696281010985	dimer interface [polypeptide binding]; other site
696281010986	phosphorylation site [posttranslational modification]
696281010987	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
696281010988	ATP binding site [chemical binding]; other site
696281010989	Mg2+ binding site [ion binding]; other site
696281010990	G-X-G motif; other site
696281010991	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
696281010992	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
696281010993	active site
696281010994	phosphorylation site [posttranslational modification]
696281010995	intermolecular recognition site; other site
696281010996	dimerization interface [polypeptide binding]; other site
696281010997	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
696281010998	DNA binding site [nucleotide binding]
696281010999	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
696281011000	putative CheW interface [polypeptide binding]; other site
696281011001	Cache domain; Region: Cache_1; pfam02743
696281011002	Periplasmic lysozyme inhibitor, I-type (PliI) and similar proteins; Region: PliI_like; cd09632
696281011003	putative inhibitory loop; other site
696281011004	ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730
696281011005	ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277
696281011006	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
696281011007	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
696281011008	Walker A/P-loop; other site
696281011009	ATP binding site [chemical binding]; other site
696281011010	Q-loop/lid; other site
696281011011	ABC transporter signature motif; other site
696281011012	Walker B; other site
696281011013	D-loop; other site
696281011014	H-loop/switch region; other site
696281011015	Predicted transcriptional regulators [Transcription]; Region: COG1725
696281011016	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
696281011017	DNA-binding site [nucleotide binding]; DNA binding site
696281011018	Domain of unknown function (DUF4179); Region: DUF4179; pfam13786
696281011019	RNA polymerase sigma-70 factor, TIGR02954 family; Region: Sig70_famx3
696281011020	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
696281011021	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
696281011022	DNA binding residues [nucleotide binding]
696281011023	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
696281011024	4Fe-4S dicluster domain; Region: Fer4_9; pfam13187
696281011025	Nitroreductase family. Members of this family utilize FMN as a cofactor. This family is involved in the reduction of flavin or nitroaromatic compounds by using NAD(P)H as electron donor in a obligatory two-electron transfer. Nitrogenase is homodimer; Region: NADH_nitroreductase; cd02143
696281011026	putative FMN binding site [chemical binding]; other site
696281011027	Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655
696281011028	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
696281011029	Predicted transcriptional regulators [Transcription]; Region: COG1733
696281011030	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
696281011031	dimerization interface [polypeptide binding]; other site
696281011032	putative DNA binding site [nucleotide binding]; other site
696281011033	putative Zn2+ binding site [ion binding]; other site
696281011034	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
696281011035	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
696281011036	DNA-binding site [nucleotide binding]; DNA binding site
696281011037	The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866
696281011038	L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cl00947
696281011039	hexamer (dimer of trimers) interface [polypeptide binding]; other site
696281011040	trimer interface [polypeptide binding]; other site
696281011041	substrate binding site [chemical binding]; other site
696281011042	Mn binding site [ion binding]; other site
696281011043	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
696281011044	intersubunit interface [polypeptide binding]; other site
696281011045	active site
696281011046	zinc binding site [ion binding]; other site
696281011047	Na+ binding site [ion binding]; other site
696281011048	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
696281011049	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
696281011050	Putative oxidoreductase C terminal; Region: ox_reductase_C; pfam08635
696281011051	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
696281011052	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
696281011053	dimer interface [polypeptide binding]; other site
696281011054	conserved gate region; other site
696281011055	putative PBP binding loops; other site
696281011056	ABC-ATPase subunit interface; other site
696281011057	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
696281011058	dimer interface [polypeptide binding]; other site
696281011059	conserved gate region; other site
696281011060	putative PBP binding loops; other site
696281011061	ABC-ATPase subunit interface; other site
696281011062	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
696281011063	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
696281011064	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
696281011065	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
696281011066	Walker A/P-loop; other site
696281011067	ATP binding site [chemical binding]; other site
696281011068	Q-loop/lid; other site
696281011069	ABC transporter signature motif; other site
696281011070	Walker B; other site
696281011071	D-loop; other site
696281011072	H-loop/switch region; other site
696281011073	TOBE domain; Region: TOBE_2; pfam08402
696281011074	Aldose 1-epimerase, similar to Escherichia coli c4013; Region: Aldose_epim_Ec_c4013; cd09023
696281011075	active site
696281011076	catalytic residues [active]
696281011077	Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204
696281011078	6-phosphofructokinase; Region: PFKA_ATP; TIGR02482
696281011079	active site
696281011080	ADP/pyrophosphate binding site [chemical binding]; other site
696281011081	dimerization interface [polypeptide binding]; other site
696281011082	allosteric effector site; other site
696281011083	fructose-1,6-bisphosphate binding site; other site
696281011084	Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931
696281011085	tRNA-binding-domain-containing CsaA-like proteins. CsaA is a molecular chaperone with export related activities. CsaA has a putative tRNA binding activity. The functional unit of CsaA is a homodimer and this domain acts as a dimerization domain; Region: tRNA_bind_CsaA; cd02798
696281011086	dimer interface [polypeptide binding]; other site
696281011087	putative tRNA-binding site [nucleotide binding]; other site
696281011088	Cupin domain; Region: Cupin_2; pfam07883
696281011089	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
696281011090	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
696281011091	Clp protease; Region: CLP_protease; pfam00574
696281011092	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
696281011093	oligomer interface [polypeptide binding]; other site
696281011094	active site residues [active]
696281011095	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
696281011096	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
696281011097	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
696281011098	rRNA large subunit methyltransferase; Provisional; Region: PRK00103
696281011099	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
696281011100	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
696281011101	hinge; other site
696281011102	active site
696281011103	Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485
696281011104	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
696281011105	binding surface
696281011106	TPR motif; other site
696281011107	TPR repeat; Region: TPR_11; pfam13414
696281011108	putative bifunctional molybdopterin-guanine dinucleotide biosynthesis protein MobB/MoaE; Provisional; Region: PRK14493
696281011109	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
696281011110	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
696281011111	G5 domain; Region: G5; pfam07501
696281011112	Peptidase family M23; Region: Peptidase_M23; pfam01551
696281011113	SCIFF radical SAM maturase; Region: rSAM_six_Cys; TIGR03974
696281011114	PqqD family protein, HPr-rel-A system; Region: PqqD_rel_X; TIGR04353
696281011115	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
696281011116	FeS/SAM binding site; other site
696281011117	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
696281011118	Protein of unknown function (DUF4001); Region: DUF4001; pfam13165
696281011119	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
696281011120	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
696281011121	GDP-binding site [chemical binding]; other site
696281011122	ACT binding site; other site
696281011123	IMP binding site; other site
696281011124	replicative DNA helicase; Region: DnaB; TIGR00665
696281011125	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
696281011126	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
696281011127	Walker A motif; other site
696281011128	ATP binding site [chemical binding]; other site
696281011129	Walker B motif; other site
696281011130	DNA binding loops [nucleotide binding]
696281011131	ATP-dependent protease, Lon family; Region: spore_lon_C; TIGR02903
696281011132	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
696281011133	Walker A motif; other site
696281011134	ATP binding site [chemical binding]; other site
696281011135	Walker B motif; other site
696281011136	arginine finger; other site
696281011137	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
696281011138	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
696281011139	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
696281011140	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
696281011141	Predicted membrane protein (DUF2232); Region: DUF2232; pfam09991
696281011142	30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391
696281011143	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
696281011144	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
696281011145	dimer interface [polypeptide binding]; other site
696281011146	ssDNA binding site [nucleotide binding]; other site
696281011147	tetramer (dimer of dimers) interface [polypeptide binding]; other site
696281011148	30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453
696281011149	Bacterial protein of unknown function (DUF951); Region: DUF951; pfam06107
696281011150	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
696281011151	Mechanosensitive ion channel; Region: MS_channel; pfam00924
696281011152	M18 Peptidase Aminopeptidase I; Region: M18_API; cd05659
696281011153	Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127
696281011154	oligomer interface [polypeptide binding]; other site
696281011155	putative active site [active]
696281011156	metal binding site [ion binding]; metal-binding site
696281011157	Uncharacterized membrane protein [Function unknown]; Region: COG3949
696281011158	Protein of unknown function (DUF1256); Region: DUF1256; cl06087
696281011159	EDD domain protein, DegV family; Region: DegV; TIGR00762
696281011160	Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645
696281011161	Protein of unknown function (DUF554); Region: DUF554; pfam04474
696281011162	ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180
696281011163	ParB-like nuclease domain; Region: ParBc; pfam02195
696281011164	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
696281011165	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
696281011166	P-loop; other site
696281011167	Magnesium ion binding site [ion binding]; other site
696281011168	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
696281011169	Magnesium ion binding site [ion binding]; other site
696281011170	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
696281011171	AsnC family; Region: AsnC_trans_reg; pfam01037
696281011172	LysE type translocator; Region: LysE; cl00565
696281011173	Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357
696281011174	16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107
696281011175	tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192
696281011176	tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335
696281011177	NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206
696281011178	GidA associated domain 3; Region: GIDA_assoc_3; pfam13932
696281011179	tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291
696281011180	GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396
696281011181	trmE is a tRNA modification GTPase; Region: trmE; cd04164
696281011182	G1 box; other site
696281011183	GTP/Mg2+ binding site [chemical binding]; other site
696281011184	Switch I region; other site
696281011185	G2 box; other site
696281011186	Switch II region; other site
696281011187	G3 box; other site
696281011188	G4 box; other site
696281011189	G5 box; other site
696281011190	Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631
696281011191	Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847
696281011192	jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation.  The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414
696281011193	G-X-X-G motif; other site
696281011194	R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644
696281011195	RxxxH motif; other site
696281011196	membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592
696281011197	Haemolytic domain; Region: Haemolytic; pfam01809
696281011198	ribonuclease P; Reviewed; Region: rnpA; PRK00499
696281011199	50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399