-- dump date   	20140619_060803
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
742013000001	DnaA N-terminal domain; Region: DnaA_N; pfam11638
742013000002	chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362
742013000003	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
742013000004	Walker A motif; other site
742013000005	ATP binding site [chemical binding]; other site
742013000006	Walker B motif; other site
742013000007	arginine finger; other site
742013000008	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
742013000009	DnaA box-binding interface [nucleotide binding]; other site
742013000010	DNA polymerase III subunit beta; Validated; Region: PRK05643
742013000011	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
742013000012	putative DNA binding surface [nucleotide binding]; other site
742013000013	dimer interface [polypeptide binding]; other site
742013000014	beta-clamp/clamp loader binding surface; other site
742013000015	beta-clamp/translesion DNA polymerase binding surface; other site
742013000016	DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939
742013000017	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
742013000018	ATP binding site [chemical binding]; other site
742013000019	Mg2+ binding site [ion binding]; other site
742013000020	G-X-G motif; other site
742013000021	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
742013000022	anchoring element; other site
742013000023	dimer interface [polypeptide binding]; other site
742013000024	ATP binding site [chemical binding]; other site
742013000025	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
742013000026	active site
742013000027	putative metal-binding site [ion binding]; other site
742013000028	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
742013000029	Transcriptional regulator [Transcription]; Region: LysR; COG0583
742013000030	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
742013000031	The C-terminal substrate-binding domain of putative LysR-type transcriptional regulator PAO1-like, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_PAO1_like; cd08412
742013000032	putative substrate binding pocket [chemical binding]; other site
742013000033	dimerization interface [polypeptide binding]; other site
742013000034	uncharacterized proteins similar to the Aspergillus nidulans lactam utilization protein LamB; Region: LamB_YcsF_like_2; cd11664
742013000035	putative active site [active]
742013000036	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
742013000037	carboxyltransferase (CT) interaction site; other site
742013000038	biotinylation site [posttranslational modification]; other site
742013000039	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
742013000040	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
742013000041	ATP-grasp domain; Region: ATP-grasp_4; cl17255
742013000042	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
742013000043	Allophanate hydrolase subunit 1; Region: AHS1; smart00796
742013000044	Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049
742013000045	Allophanate hydrolase subunit 2; Region: AHS2; smart00797
742013000046	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
742013000047	CoA-transferase family III; Region: CoA_transf_3; pfam02515
742013000048	Transcriptional regulator [Transcription]; Region: LysR; COG0583
742013000049	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
742013000050	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_1; cd08421
742013000051	putative dimerization interface [polypeptide binding]; other site
742013000052	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
742013000053	(R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway.  The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441
742013000054	active site
742013000055	catalytic site [active]
742013000056	Flagellin N-methylase; Region: FliB; pfam03692
742013000057	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
742013000058	dimerization interface [polypeptide binding]; other site
742013000059	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
742013000060	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
742013000061	ATP binding site [chemical binding]; other site
742013000062	Mg2+ binding site [ion binding]; other site
742013000063	G-X-G motif; other site
742013000064	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
742013000065	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
742013000066	active site
742013000067	phosphorylation site [posttranslational modification]
742013000068	intermolecular recognition site; other site
742013000069	dimerization interface [polypeptide binding]; other site
742013000070	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
742013000071	DNA binding site [nucleotide binding]
742013000072	Outer membrane efflux protein; Region: OEP; pfam02321
742013000073	Outer membrane efflux protein; Region: OEP; pfam02321
742013000074	Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696
742013000075	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
742013000076	Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999
742013000077	HlyD family secretion protein; Region: HlyD_3; pfam13437
742013000078	ATP-dependent DNA helicase DinG; Provisional; Region: dinG; PRK11747
742013000079	DEAD/DEAH box helicase; Region: DEAD; pfam00270
742013000080	Helicase C-terminal domain; Region: Helicase_C_2; pfam13307
742013000081	Lipid A 3-O-deacylase (PagL); Region: PagL; pfam09411
742013000082	LTXXQ motif family protein; Region: LTXXQ; pfam07813
742013000083	recombination associated protein; Reviewed; Region: rdgC; PRK00321
742013000084	beta-ketothiolase; Provisional; Region: PRK09051
742013000085	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
742013000086	dimer interface [polypeptide binding]; other site
742013000087	active site
742013000088	enoyl-CoA hydratase; Provisional; Region: PRK06688
742013000089	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
742013000090	substrate binding site [chemical binding]; other site
742013000091	oxyanion hole (OAH) forming residues; other site
742013000092	trimer interface [polypeptide binding]; other site
742013000093	Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022
742013000094	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
742013000095	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
742013000096	Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907
742013000097	acyl-activating enzyme (AAE) consensus motif; other site
742013000098	acyl-activating enzyme (AAE) consensus motif; other site
742013000099	putative AMP binding site [chemical binding]; other site
742013000100	putative active site [active]
742013000101	putative CoA binding site [chemical binding]; other site
742013000102	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
742013000103	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
742013000104	Walker A/P-loop; other site
742013000105	ATP binding site [chemical binding]; other site
742013000106	Q-loop/lid; other site
742013000107	ABC transporter signature motif; other site
742013000108	Walker B; other site
742013000109	D-loop; other site
742013000110	H-loop/switch region; other site
742013000111	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
742013000112	Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_1; cd06334
742013000113	putative ligand binding site [chemical binding]; other site
742013000114	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
742013000115	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
742013000116	TM-ABC transporter signature motif; other site
742013000117	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
742013000118	TM-ABC transporter signature motif; other site
742013000119	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
742013000120	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
742013000121	Walker A/P-loop; other site
742013000122	ATP binding site [chemical binding]; other site
742013000123	Q-loop/lid; other site
742013000124	ABC transporter signature motif; other site
742013000125	Walker B; other site
742013000126	D-loop; other site
742013000127	H-loop/switch region; other site
742013000128	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
742013000129	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
742013000130	Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044
742013000131	Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108
742013000132	DNA binding residues [nucleotide binding]
742013000133	dimer interface [polypeptide binding]; other site
742013000134	copper binding site [ion binding]; other site
742013000135	Copper chaperone [Inorganic ion transport and metabolism]; Region: CopZ; COG2608
742013000136	metal-binding site [ion binding]
742013000137	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
742013000138	dimerization interface [polypeptide binding]; other site
742013000139	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
742013000140	dimer interface [polypeptide binding]; other site
742013000141	putative CheW interface [polypeptide binding]; other site
742013000142	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
742013000143	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933
742013000144	FMN binding site [chemical binding]; other site
742013000145	active site
742013000146	substrate binding site [chemical binding]; other site
742013000147	catalytic residue [active]
742013000148	Predicted flavoprotein [General function prediction only]; Region: COG0431
742013000149	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
742013000150	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
742013000151	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
742013000152	N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346
742013000153	Zn binding site [ion binding]; other site
742013000154	NIPSNAP; Region: NIPSNAP; pfam07978
742013000155	2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase; Region: dhbA_paeA; TIGR04316
742013000156	classical (c) SDRs; Region: SDR_c; cd05233
742013000157	NAD(P) binding site [chemical binding]; other site
742013000158	active site
742013000159	Transcriptional regulator [Transcription]; Region: IclR; COG1414
742013000160	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
742013000161	glutathionine S-transferase; Provisional; Region: PRK10542
742013000162	GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057
742013000163	C-terminal domain interface [polypeptide binding]; other site
742013000164	GSH binding site (G-site) [chemical binding]; other site
742013000165	dimer interface [polypeptide binding]; other site
742013000166	C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188
742013000167	dimer interface [polypeptide binding]; other site
742013000168	N-terminal domain interface [polypeptide binding]; other site
742013000169	substrate binding pocket (H-site) [chemical binding]; other site
742013000170	Predicted flavoprotein [General function prediction only]; Region: COG0431
742013000171	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
742013000172	tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192
742013000173	NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206
742013000174	GidA associated domain 3; Region: GIDA_assoc_3; pfam13932
742013000175	Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357
742013000176	16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107
742013000177	LysE type translocator; Region: LysE; cl00565
742013000178	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
742013000179	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
742013000180	P-loop; other site
742013000181	Magnesium ion binding site [ion binding]; other site
742013000182	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
742013000183	Magnesium ion binding site [ion binding]; other site
742013000184	Predicted esterase of the alpha/beta hydrolase fold [General function prediction only]; Region: COG3545
742013000185	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
742013000186	Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475
742013000187	ParB-like nuclease domain; Region: ParB; smart00470
742013000188	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
742013000189	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
742013000190	sulfite oxidase; Provisional; Region: PLN00177
742013000191	Subgroup of sulfite oxidase (SO) family molybdopterin binding domains that contains conserved dimerization domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate...; Region: SO_family_Moco_dimer; cd02110
742013000192	Moco binding site; other site
742013000193	metal coordination site [ion binding]; other site
742013000194	dimerization interface [polypeptide binding]; other site
742013000195	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
742013000196	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
742013000197	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
742013000198	DNA binding residues [nucleotide binding]
742013000199	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
742013000200	Helix-turn-helix domain; Region: HTH_18; pfam12833
742013000201	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
742013000202	putative substrate translocation pore; other site
742013000203	glutamate carboxypeptidase; Reviewed; Region: PRK06133
742013000204	M20 Peptidase Glutamate carboxypeptidase, a periplasmic enzyme; Region: M20_CPDG2; cd03885
742013000205	metal binding site [ion binding]; metal-binding site
742013000206	dimer interface [polypeptide binding]; other site
742013000207	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
742013000208	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
742013000209	CoA-transferase family III; Region: CoA_transf_3; pfam02515
742013000210	Transcriptional regulator [Transcription]; Region: LysR; COG0583
742013000211	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
742013000212	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
742013000213	putative effector binding pocket; other site
742013000214	dimerization interface [polypeptide binding]; other site
742013000215	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
742013000216	FAD binding domain; Region: FAD_binding_4; pfam01565
742013000217	EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cd00051
742013000218	EF-hand domain pair; Region: EF_hand_5; pfam13499
742013000219	Ca2+ binding site [ion binding]; other site
742013000220	Cobalamin adenosyltransferase; Region: Cob_adeno_trans; pfam01923
742013000221	DNA-binding transcriptional regulator LysR; Provisional; Region: PRK11013
742013000222	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
742013000223	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
742013000224	dimerization interface [polypeptide binding]; other site
742013000225	D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711
742013000226	hydroxyglutarate oxidase; Provisional; Region: PRK11728
742013000227	hydroxyglutarate oxidase; Provisional; Region: PRK11728
742013000228	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
742013000229	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
742013000230	substrate binding pocket [chemical binding]; other site
742013000231	membrane-bound complex binding site; other site
742013000232	hinge residues; other site
742013000233	aspartate racemase; Region: asp_race; TIGR00035
742013000234	Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518
742013000235	benzoyl-CoA oxygenase/reductase, BoxA protein; Region: benzo_boxA; TIGR03224
742013000236	4Fe-4S binding domain; Region: Fer4; pfam00037
742013000237	4Fe-4S binding domain; Region: Fer4; cl02805
742013000238	Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868
742013000239	FAD binding pocket [chemical binding]; other site
742013000240	conserved FAD binding motif [chemical binding]; other site
742013000241	phosphate binding motif [ion binding]; other site
742013000242	beta-alpha-beta structure motif; other site
742013000243	NAD binding pocket [chemical binding]; other site
742013000244	Phenylacetic acid catabolic protein; Region: PaaA_PaaC; cl01346
742013000245	benzoyl-CoA-dihydrodiol lyase; Provisional; Region: PRK08184
742013000246	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
742013000247	substrate binding site [chemical binding]; other site
742013000248	oxyanion hole (OAH) forming residues; other site
742013000249	trimer interface [polypeptide binding]; other site
742013000250	anaerobic benzoate catabolism transcriptional regulator; Reviewed; Region: PRK08154
742013000251	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
742013000252	sequence-specific DNA binding site [nucleotide binding]; other site
742013000253	salt bridge; other site
742013000254	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
742013000255	ADP binding site [chemical binding]; other site
742013000256	magnesium binding site [ion binding]; other site
742013000257	putative shikimate binding site; other site
742013000258	benzoate-CoA ligase family; Region: benz_CoA_lig; TIGR02262
742013000259	Benzoate CoA ligase (BCL) and 4-Hydroxybenzoate-Coenzyme A Ligase (4-HBA-CoA ligase); Region: BCL_4HBCL; cd05959
742013000260	dimer interface [polypeptide binding]; other site
742013000261	acyl-activating enzyme (AAE) consensus motif; other site
742013000262	putative active site [active]
742013000263	putative AMP binding site [chemical binding]; other site
742013000264	putative CoA binding site [chemical binding]; other site
742013000265	chemical substrate binding site [chemical binding]; other site
742013000266	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
742013000267	Type I periplasmic binding component of active transport systems that are predicted be involved in anaerobic biodegradation of alkylbenzenes such as toluene and ethylbenzene; Region: PBP1_alkylbenzenes_like; cd06360
742013000268	putative ligand binding site [chemical binding]; other site
742013000269	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
742013000270	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
742013000271	TM-ABC transporter signature motif; other site
742013000272	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
742013000273	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
742013000274	TM-ABC transporter signature motif; other site
742013000275	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
742013000276	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
742013000277	Walker A/P-loop; other site
742013000278	ATP binding site [chemical binding]; other site
742013000279	Q-loop/lid; other site
742013000280	ABC transporter signature motif; other site
742013000281	Walker B; other site
742013000282	D-loop; other site
742013000283	H-loop/switch region; other site
742013000284	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
742013000285	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
742013000286	Walker A/P-loop; other site
742013000287	ATP binding site [chemical binding]; other site
742013000288	Q-loop/lid; other site
742013000289	ABC transporter signature motif; other site
742013000290	Walker B; other site
742013000291	D-loop; other site
742013000292	H-loop/switch region; other site
742013000293	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
742013000294	CoenzymeA binding site [chemical binding]; other site
742013000295	subunit interaction site [polypeptide binding]; other site
742013000296	PHB binding site; other site
742013000297	Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550
742013000298	succinate CoA transferase; Region: YgfH_subfam; TIGR03458
742013000299	Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336
742013000300	uracil-xanthine permease; Region: ncs2; TIGR00801
742013000301	acetoacetyl-CoA synthetase; Provisional; Region: PRK03584
742013000302	Acetoacetyl-CoA synthetase (acetoacetate-CoA ligase, AACS); Region: AACS; cd05943
742013000303	acyl-activating enzyme (AAE) consensus motif; other site
742013000304	putative AMP binding site [chemical binding]; other site
742013000305	putative active site [active]
742013000306	putative CoA binding site [chemical binding]; other site
742013000307	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
742013000308	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
742013000309	active site
742013000310	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
742013000311	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
742013000312	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
742013000313	enoyl-CoA hydratase; Provisional; Region: PRK09245
742013000314	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
742013000315	substrate binding site [chemical binding]; other site
742013000316	oxyanion hole (OAH) forming residues; other site
742013000317	trimer interface [polypeptide binding]; other site
742013000318	septum formation inhibitor; Reviewed; Region: PRK01973
742013000319	Septum formation inhibitor MinC, N-terminal domain; Region: MinC_N; pfam05209
742013000320	Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775
742013000321	Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894
742013000322	Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036
742013000323	Switch I; other site
742013000324	Switch II; other site
742013000325	cell division topological specificity factor MinE; Provisional; Region: PRK13989
742013000326	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
742013000327	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
742013000328	ATP binding site [chemical binding]; other site
742013000329	Mg2+ binding site [ion binding]; other site
742013000330	G-X-G motif; other site
742013000331	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
742013000332	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
742013000333	active site
742013000334	phosphorylation site [posttranslational modification]
742013000335	intermolecular recognition site; other site
742013000336	dimerization interface [polypeptide binding]; other site
742013000337	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
742013000338	DNA binding site [nucleotide binding]
742013000339	Predicted membrane protein [Function unknown]; Region: COG3212
742013000340	Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413
742013000341	Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413
742013000342	Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413
742013000343	putative proline-specific permease; Provisional; Region: proY; PRK10580
742013000344	Spore germination protein; Region: Spore_permease; cl17796
742013000345	Flavin reductase like domain; Region: Flavin_Reduct; smart00903
742013000346	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
742013000347	active site
742013000348	catalytic site [active]
742013000349	substrate binding site [chemical binding]; other site
742013000350	MarR family; Region: MarR_2; cl17246
742013000351	HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231
742013000352	succinic semialdehyde dehydrogenase; Region: PLN02278
742013000353	Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103
742013000354	tetramerization interface [polypeptide binding]; other site
742013000355	NAD(P) binding site [chemical binding]; other site
742013000356	catalytic residues [active]
742013000357	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421
742013000358	5-carboxymethyl-2-hydroxymuconate isomerase (CHMI) is a trimeric enzyme catalyzing the isomerization of the unsaturated ketone 5-(carboxymethyl)-2-hydroxymuconate to 5-(carboxymethyl)-2-oxo-3-hexene-1,6-dionate. This is one step in the...; Region: CHMI; cd00580
742013000359	putative substrate binding pocket [chemical binding]; other site
742013000360	trimer interface [polypeptide binding]; other site
742013000361	Subunit B of the Class III Extradiol dioxygenase, Protocatechuate 4,5-dioxygenase, and simlar enzymes; Region: PCA_45_Doxase_B_like; cd07359
742013000362	active site
742013000363	Fe(II) binding site [ion binding]; other site
742013000364	dimer interface [polypeptide binding]; other site
742013000365	tetramer interface [polypeptide binding]; other site
742013000366	Subunit A of Class III extradiol dioxygenases; Region: Extradiol_Dioxygenase_3A_like; cd07321
742013000367	dimer interface [polypeptide binding]; other site
742013000368	tetramer interface [polypeptide binding]; other site
742013000369	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
742013000370	5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenase; Region: HpaE; TIGR02299
742013000371	Human aldehyde dehydrogenase family 8 member A1-like; Region: ALDH_F8_HMSADH; cd07093
742013000372	NAD binding site [chemical binding]; other site
742013000373	catalytic residues [active]
742013000374	4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase, C-terminal subunit; Region: HpaG-C-term; TIGR02303
742013000375	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
742013000376	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421
742013000377	Protein of unknown function (DUF3616); Region: DUF3616; pfam12275
742013000378	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
742013000379	Ligand Binding Site [chemical binding]; other site
742013000380	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
742013000381	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
742013000382	active site
742013000383	metal binding site [ion binding]; metal-binding site
742013000384	Transcriptional regulator [Transcription]; Region: LysR; COG0583
742013000385	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
742013000386	The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417
742013000387	substrate binding pocket [chemical binding]; other site
742013000388	dimerization interface [polypeptide binding]; other site
742013000389	Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819
742013000390	active site
742013000391	substrate-binding site [chemical binding]; other site
742013000392	metal-binding site [ion binding]
742013000393	GTP binding site [chemical binding]; other site
742013000394	threonine dehydratase; Provisional; Region: PRK07334
742013000395	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
742013000396	tetramer interface [polypeptide binding]; other site
742013000397	pyridoxal 5'-phosphate binding site [chemical binding]; other site
742013000398	catalytic residue [active]
742013000399	C-terminal ACT domain of biodegradative (catabolic) threonine dehydratase II (ThrD-II) and other related ACT domains; Region: ACT_ThrD-II-like; cd04886
742013000400	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
742013000401	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
742013000402	Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375
742013000403	Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193
742013000404	FAD binding pocket [chemical binding]; other site
742013000405	FAD binding motif [chemical binding]; other site
742013000406	phosphate binding motif [ion binding]; other site
742013000407	NAD binding pocket [chemical binding]; other site
742013000408	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187
742013000409	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
742013000410	Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929
742013000411	acyl-activating enzyme (AAE) consensus motif; other site
742013000412	putative AMP binding site [chemical binding]; other site
742013000413	putative active site [active]
742013000414	putative CoA binding site [chemical binding]; other site
742013000415	isovaleryl CoA dehydrogenase; Provisional; Region: PRK11561
742013000416	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
742013000417	active site
742013000418	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
742013000419	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
742013000420	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
742013000421	dimerization interface [polypeptide binding]; other site
742013000422	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
742013000423	dimer interface [polypeptide binding]; other site
742013000424	phosphorylation site [posttranslational modification]
742013000425	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
742013000426	ATP binding site [chemical binding]; other site
742013000427	Mg2+ binding site [ion binding]; other site
742013000428	G-X-G motif; other site
742013000429	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
742013000430	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
742013000431	active site
742013000432	phosphorylation site [posttranslational modification]
742013000433	intermolecular recognition site; other site
742013000434	dimerization interface [polypeptide binding]; other site
742013000435	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
742013000436	DNA binding site [nucleotide binding]
742013000437	putative major fimbrial protein SthE; Provisional; Region: PRK15292
742013000438	P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539
742013000439	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
742013000440	FtsX-like permease family; Region: FtsX; pfam02687
742013000441	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
742013000442	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
742013000443	Walker A/P-loop; other site
742013000444	ATP binding site [chemical binding]; other site
742013000445	Q-loop/lid; other site
742013000446	ABC transporter signature motif; other site
742013000447	Walker B; other site
742013000448	D-loop; other site
742013000449	H-loop/switch region; other site
742013000450	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
742013000451	HlyD family secretion protein; Region: HlyD_3; pfam13437
742013000452	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
742013000453	Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419
742013000454	Esterase/lipase [General function prediction only]; Region: COG1647
742013000455	4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnE; Provisional; Region: PRK15051
742013000456	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
742013000457	EamA-like transporter family; Region: EamA; pfam00892
742013000458	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
742013000459	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
742013000460	catalytic residue [active]
742013000461	Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230
742013000462	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
742013000463	S-adenosylmethionine binding site [chemical binding]; other site
742013000464	Arginase-like and histone-like hydrolases; Region: Arginase_HDAC; cl17011
742013000465	active site
742013000466	metal binding site [ion binding]; metal-binding site
742013000467	Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480
742013000468	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
742013000469	4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism]; Region: GabT; COG0160
742013000470	inhibitor-cofactor binding pocket; inhibition site
742013000471	pyridoxal 5'-phosphate binding site [chemical binding]; other site
742013000472	catalytic residue [active]
742013000473	TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786
742013000474	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
742013000475	N-terminal plug; other site
742013000476	ligand-binding site [chemical binding]; other site
742013000477	Domain of unknown function (DUF4198); Region: DUF4198; pfam10670
742013000478	ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389
742013000479	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
742013000480	ATP binding site [chemical binding]; other site
742013000481	putative Mg++ binding site [ion binding]; other site
742013000482	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
742013000483	nucleotide binding region [chemical binding]; other site
742013000484	ATP-binding site [chemical binding]; other site
742013000485	This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956
742013000486	HRDC domain; Region: HRDC; pfam00570
742013000487	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
742013000488	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
742013000489	active site
742013000490	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
742013000491	CoA-transferase family III; Region: CoA_transf_3; pfam02515
742013000492	Transcriptional regulator [Transcription]; Region: LysR; COG0583
742013000493	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
742013000494	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
742013000495	dimerization interface [polypeptide binding]; other site
742013000496	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
742013000497	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
742013000498	substrate binding pocket [chemical binding]; other site
742013000499	membrane-bound complex binding site; other site
742013000500	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
742013000501	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
742013000502	dimer interface [polypeptide binding]; other site
742013000503	conserved gate region; other site
742013000504	putative PBP binding loops; other site
742013000505	ABC-ATPase subunit interface; other site
742013000506	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
742013000507	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
742013000508	Walker A/P-loop; other site
742013000509	ATP binding site [chemical binding]; other site
742013000510	Q-loop/lid; other site
742013000511	ABC transporter signature motif; other site
742013000512	Walker B; other site
742013000513	D-loop; other site
742013000514	H-loop/switch region; other site
742013000515	histidine utilization repressor, proteobacterial; Region: his_ut_repres; TIGR02018
742013000516	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
742013000517	DNA-binding site [nucleotide binding]; DNA binding site
742013000518	UTRA domain; Region: UTRA; pfam07702
742013000519	Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332
742013000520	active sites [active]
742013000521	tetramer interface [polypeptide binding]; other site
742013000522	urocanate hydratase; Provisional; Region: PRK05414
742013000523	HutD; Region: HutD; pfam05962
742013000524	imidazolonepropionase; Validated; Region: PRK09356
742013000525	Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296
742013000526	active site
742013000527	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
742013000528	FAD binding domain; Region: FAD_binding_4; pfam01565
742013000529	histidinol-phosphate aminotransferase; Provisional; Region: PRK05166
742013000530	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
742013000531	pyridoxal 5'-phosphate binding site [chemical binding]; other site
742013000532	homodimer interface [polypeptide binding]; other site
742013000533	catalytic residue [active]
742013000534	N-formimino-L-glutamate deiminase; Validated; Region: PRK09229
742013000535	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
742013000536	active site
742013000537	N-formylglutamate amidohydrolase; Region: FGase; cl01522
742013000538	redox-sensitive transcriptional activator SoxR; Region: SoxR; TIGR01950
742013000539	Helix-Turn-Helix DNA binding domain of the SoxR transcription regulator; Region: HTH_SoxR; cd01110
742013000540	DNA binding residues [nucleotide binding]
742013000541	dimer interface [polypeptide binding]; other site
742013000542	[2Fe-2S] cluster binding site [ion binding]; other site
742013000543	homogentisate 1,2-dioxygenase; Region: HgmA; cl17306
742013000544	Helix-turn-helix domain; Region: HTH_18; pfam12833
742013000545	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
742013000546	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
742013000547	RT_Bac_retron_II: Reverse transcriptases (RTs) in bacterial retrotransposons or retrons. The polymerase reaction of this enzyme leads to the production of a unique RNA-DNA complex called msDNA (multicopy single-stranded (ss)DNA) in which a small ssDNA...; Region: RT_Bac_retron_II; cd03487
742013000548	putative active site [active]
742013000549	putative NTP binding site [chemical binding]; other site
742013000550	putative nucleic acid binding site [nucleotide binding]; other site
742013000551	SWIM zinc finger; Region: SWIM; pfam04434
742013000552	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
742013000553	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
742013000554	HlyD family secretion protein; Region: HlyD_3; pfam13437
742013000555	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
742013000556	Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538
742013000557	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
742013000558	hydroxyglutarate oxidase; Provisional; Region: PRK11728
742013000559	Uncharacterized membrane protein [Function unknown]; Region: COG3949
742013000560	DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943
742013000561	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
742013000562	non-specific DNA binding site [nucleotide binding]; other site
742013000563	salt bridge; other site
742013000564	sequence-specific DNA binding site [nucleotide binding]; other site
742013000565	Cupin domain; Region: Cupin_2; pfam07883
742013000566	Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646
742013000567	Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574
742013000568	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
742013000569	trimer interface [polypeptide binding]; other site
742013000570	eyelet of channel; other site
742013000571	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
742013000572	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
742013000573	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
742013000574	dimerization interface [polypeptide binding]; other site
742013000575	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
742013000576	dimer interface [polypeptide binding]; other site
742013000577	putative CheW interface [polypeptide binding]; other site
742013000578	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
742013000579	CoA-transferase family III; Region: CoA_transf_3; pfam02515
742013000580	Transcriptional regulator [Transcription]; Region: LysR; COG0583
742013000581	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
742013000582	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_1; cd08421
742013000583	putative dimerization interface [polypeptide binding]; other site
742013000584	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
742013000585	CoenzymeA binding site [chemical binding]; other site
742013000586	subunit interaction site [polypeptide binding]; other site
742013000587	PHB binding site; other site
742013000588	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
742013000589	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
742013000590	active site
742013000591	thiolase; Provisional; Region: PRK06158
742013000592	Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2  has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829
742013000593	active site
742013000594	Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172
742013000595	DUF35 OB-fold domain; Region: DUF35; pfam01796
742013000596	Acetamidase/Formamidase family; Region: FmdA_AmdA; pfam03069
742013000597	Zinc ribbon domain; Region: CxxC_CxxC_SSSS; pfam09723
742013000598	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
742013000599	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
742013000600	Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327
742013000601	putative ligand binding site [chemical binding]; other site
742013000602	Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062
742013000603	Zinc-dependent alcohol dehydrogenases (ADH) and class III ADG (AKA formaldehyde dehydrogenase); Region: liver_ADH_like1; cd08281
742013000604	NAD binding site [chemical binding]; other site
742013000605	catalytic Zn binding site [ion binding]; other site
742013000606	substrate binding site [chemical binding]; other site
742013000607	structural Zn binding site [ion binding]; other site
742013000608	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
742013000609	Amidase; Region: Amidase; cl11426
742013000610	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
742013000611	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
742013000612	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
742013000613	acyl-activating enzyme (AAE) consensus motif; other site
742013000614	AMP binding site [chemical binding]; other site
742013000615	active site
742013000616	CoA binding site [chemical binding]; other site
742013000617	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
742013000618	Transcriptional regulator [Transcription]; Region: LysR; COG0583
742013000619	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
742013000620	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
742013000621	dimerization interface [polypeptide binding]; other site
742013000622	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
742013000623	CoA-transferase family III; Region: CoA_transf_3; pfam02515
742013000624	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
742013000625	Quinone oxidoreductase (QOR); Region: QOR1; cd08241
742013000626	NAD(P) binding site [chemical binding]; other site
742013000627	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
742013000628	acetyl-CoA acetyltransferase; Provisional; Region: PRK06205
742013000629	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
742013000630	dimer interface [polypeptide binding]; other site
742013000631	active site
742013000632	succinate CoA transferase; Region: YgfH_subfam; TIGR03458
742013000633	Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550
742013000634	Coenzyme A transferase; Region: CoA_trans; cl17247
742013000635	Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336
742013000636	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
742013000637	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
742013000638	substrate binding site [chemical binding]; other site
742013000639	oxyanion hole (OAH) forming residues; other site
742013000640	trimer interface [polypeptide binding]; other site
742013000641	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
742013000642	enoyl-CoA hydratase; Region: PLN02864
742013000643	HDE_HSD  The R-hydratase-like hot dog fold of the 17-beta-hydroxysteriod dehydrogenase (HSD), and Hydratase-Dehydrogenase-Epimerase (HDE) proteins.  Other enzymes with this fold include MaoC dehydratase, and the fatty acid synthase beta subunit; Region: HDE_HSD; cd03448
742013000644	dimer interaction site [polypeptide binding]; other site
742013000645	substrate-binding tunnel; other site
742013000646	active site
742013000647	catalytic site [active]
742013000648	substrate binding site [chemical binding]; other site
742013000649	short chain dehydrogenase; Provisional; Region: PRK07791
742013000650	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
742013000651	NAD(P) binding site [chemical binding]; other site
742013000652	active site
742013000653	Uncharacterized conserved protein [Function unknown]; Region: COG3777
742013000654	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
742013000655	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
742013000656	active site 2 [active]
742013000657	active site 1 [active]
742013000658	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
742013000659	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
742013000660	active site
742013000661	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
742013000662	CoA-transferase family III; Region: CoA_transf_3; pfam02515
742013000663	MmgE/PrpD family; Region: MmgE_PrpD; cl00912
742013000664	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
742013000665	Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301
742013000666	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
742013000667	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
742013000668	CoenzymeA binding site [chemical binding]; other site
742013000669	subunit interaction site [polypeptide binding]; other site
742013000670	PHB binding site; other site
742013000671	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
742013000672	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
742013000673	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
742013000674	Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929
742013000675	acyl-activating enzyme (AAE) consensus motif; other site
742013000676	acyl-activating enzyme (AAE) consensus motif; other site
742013000677	putative AMP binding site [chemical binding]; other site
742013000678	putative active site [active]
742013000679	putative CoA binding site [chemical binding]; other site
742013000680	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
742013000681	Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334
742013000682	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
742013000683	NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076
742013000684	NAD(P) binding site [chemical binding]; other site
742013000685	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
742013000686	polyphosphate:nucleotide phosphotransferase, PPK2 family; Region: PPK2_rel_1; TIGR03709
742013000687	Peptidase M30; Region: Peptidase_M30; pfam10460
742013000688	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
742013000689	Transcriptional regulator [Transcription]; Region: LysR; COG0583
742013000690	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
742013000691	dimerization interface [polypeptide binding]; other site
742013000692	Predicted membrane protein [Function unknown]; Region: COG4125
742013000693	Bacterial Transmembrane Pair family; Region: BTP; pfam05232
742013000694	Bacterial Transmembrane Pair family; Region: BTP; pfam05232
742013000695	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
742013000696	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
742013000697	active site
742013000698	phosphorylation site [posttranslational modification]
742013000699	intermolecular recognition site; other site
742013000700	dimerization interface [polypeptide binding]; other site
742013000701	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
742013000702	DNA binding residues [nucleotide binding]
742013000703	dimerization interface [polypeptide binding]; other site
742013000704	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
742013000705	Prokaryotic RING finger family 1; Region: Prok-RING_1; pfam14446
742013000706	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
742013000707	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
742013000708	dimer interface [polypeptide binding]; other site
742013000709	phosphorylation site [posttranslational modification]
742013000710	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
742013000711	ATP binding site [chemical binding]; other site
742013000712	Mg2+ binding site [ion binding]; other site
742013000713	G-X-G motif; other site
742013000714	Response regulator receiver domain; Region: Response_reg; pfam00072
742013000715	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
742013000716	active site
742013000717	phosphorylation site [posttranslational modification]
742013000718	intermolecular recognition site; other site
742013000719	dimerization interface [polypeptide binding]; other site
742013000720	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
742013000721	Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355
742013000722	putative ligand binding site [chemical binding]; other site
742013000723	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
742013000724	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
742013000725	TM-ABC transporter signature motif; other site
742013000726	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
742013000727	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
742013000728	TM-ABC transporter signature motif; other site
742013000729	urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411
742013000730	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
742013000731	Walker A/P-loop; other site
742013000732	ATP binding site [chemical binding]; other site
742013000733	Q-loop/lid; other site
742013000734	ABC transporter signature motif; other site
742013000735	Walker B; other site
742013000736	D-loop; other site
742013000737	H-loop/switch region; other site
742013000738	urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410
742013000739	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
742013000740	Walker A/P-loop; other site
742013000741	ATP binding site [chemical binding]; other site
742013000742	Q-loop/lid; other site
742013000743	ABC transporter signature motif; other site
742013000744	Walker B; other site
742013000745	D-loop; other site
742013000746	H-loop/switch region; other site
742013000747	Acetamidase/Formamidase family; Region: FmdA_AmdA; pfam03069
742013000748	Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993
742013000749	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
742013000750	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
742013000751	Walker A/P-loop; other site
742013000752	ATP binding site [chemical binding]; other site
742013000753	Q-loop/lid; other site
742013000754	ABC transporter signature motif; other site
742013000755	Walker B; other site
742013000756	D-loop; other site
742013000757	H-loop/switch region; other site
742013000758	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
742013000759	dimer interface [polypeptide binding]; other site
742013000760	conserved gate region; other site
742013000761	putative PBP binding loops; other site
742013000762	ABC-ATPase subunit interface; other site
742013000763	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
742013000764	dimer interface [polypeptide binding]; other site
742013000765	conserved gate region; other site
742013000766	putative PBP binding loops; other site
742013000767	ABC-ATPase subunit interface; other site
742013000768	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
742013000769	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
742013000770	substrate binding pocket [chemical binding]; other site
742013000771	membrane-bound complex binding site; other site
742013000772	hinge residues; other site
742013000773	phosphonate utilization associated transcriptional regulator; Region: phnR_burk; TIGR03338
742013000774	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
742013000775	DNA-binding site [nucleotide binding]; DNA binding site
742013000776	FCD domain; Region: FCD; pfam07729
742013000777	Methionine synthase I, cobalamin-binding domain [Amino acid transport and metabolism]; Region: MetH; COG1410
742013000778	MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH).  Cobalamin-dependent...; Region: MeTr; cd00740
742013000779	substrate binding pocket [chemical binding]; other site
742013000780	B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069
742013000781	B12 binding site [chemical binding]; other site
742013000782	cobalt ligand [ion binding]; other site
742013000783	Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965
742013000784	Uncharacterized protein conserved in bacteria (DUF2195); Region: DUF2195; cl02042
742013000785	glycerophosphodiester phosphodiesterase; Provisional; Region: glpQ; PRK11143
742013000786	Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615
742013000787	active site
742013000788	catalytic site [active]
742013000789	Transcriptional regulators [Transcription]; Region: GntR; COG1802
742013000790	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
742013000791	DNA-binding site [nucleotide binding]; DNA binding site
742013000792	FCD domain; Region: FCD; pfam07729
742013000793	C4-dicarboxylate transporter DctA; Reviewed; Region: PRK13027
742013000794	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
742013000795	citrate-proton symporter; Provisional; Region: PRK15075
742013000796	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
742013000797	putative substrate translocation pore; other site
742013000798	acetylornithine deacetylase; Provisional; Region: PRK07522
742013000799	M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894
742013000800	metal binding site [ion binding]; metal-binding site
742013000801	putative dimer interface [polypeptide binding]; other site
742013000802	Putative cyclase; Region: Cyclase; pfam04199
742013000803	Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761
742013000804	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
742013000805	Transcriptional regulator [Transcription]; Region: LysR; COG0583
742013000806	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
742013000807	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
742013000808	putative effector binding pocket; other site
742013000809	dimerization interface [polypeptide binding]; other site
742013000810	Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824
742013000811	PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274
742013000812	PhnA protein; Region: PhnA; pfam03831
742013000813	Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130
742013000814	pseudouridine synthase; Region: TIGR00093
742013000815	active site
742013000816	DNA-binding transcriptional regulator CynR; Provisional; Region: PRK11242
742013000817	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
742013000818	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
742013000819	dimerization interface [polypeptide binding]; other site
742013000820	LrgA family; Region: LrgA; pfam03788
742013000821	Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346
742013000822	Bacillus subtilis NADP+-dependent alpha-ketoglutaric semialdehyde dehydrogenase ycbD-like; Region: ALDH_KGSADH-YcbD; cd07097
742013000823	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
742013000824	NAD(P) binding site [chemical binding]; other site
742013000825	catalytic residues [active]
742013000826	glucarate dehydratase; Region: glucar-dehydr; TIGR03247
742013000827	D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323
742013000828	active site
742013000829	tetramer interface [polypeptide binding]; other site
742013000830	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
742013000831	Hydroxy(phenyl)pyruvate Reductase, D-isomer-specific 2-hydroxyacid-related dehydrogenase; Region: HPPR; cd12156
742013000832	putative ligand binding site [chemical binding]; other site
742013000833	NAD binding site [chemical binding]; other site
742013000834	catalytic site [active]
742013000835	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
742013000836	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
742013000837	5-dehydro-4-deoxyglucarate dehydratase, also called 5-keto-4-deoxy-glucarate dehydratase (KDGDH); Region: KDGDH; cd00951
742013000838	putative active site [active]
742013000839	catalytic residue [active]
742013000840	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
742013000841	Transcriptional regulators [Transcription]; Region: FadR; COG2186
742013000842	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
742013000843	DNA-binding site [nucleotide binding]; DNA binding site
742013000844	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
742013000845	D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323
742013000846	glucarate dehydratase; Region: glucar-dehydr; TIGR03247
742013000847	active site
742013000848	tetramer interface [polypeptide binding]; other site
742013000849	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
742013000850	galactarate dehydratase; Region: galactar-dH20; TIGR03248
742013000851	Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613
742013000852	D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295
742013000853	Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631
742013000854	Transcriptional regulator [Transcription]; Region: LysR; COG0583
742013000855	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
742013000856	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
742013000857	putative effector binding pocket; other site
742013000858	dimerization interface [polypeptide binding]; other site
742013000859	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
742013000860	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
742013000861	TM-ABC transporter signature motif; other site
742013000862	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
742013000863	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
742013000864	TM-ABC transporter signature motif; other site
742013000865	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
742013000866	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
742013000867	Walker A/P-loop; other site
742013000868	ATP binding site [chemical binding]; other site
742013000869	Q-loop/lid; other site
742013000870	ABC transporter signature motif; other site
742013000871	Walker B; other site
742013000872	D-loop; other site
742013000873	H-loop/switch region; other site
742013000874	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
742013000875	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
742013000876	Walker A/P-loop; other site
742013000877	ATP binding site [chemical binding]; other site
742013000878	Q-loop/lid; other site
742013000879	ABC transporter signature motif; other site
742013000880	Walker B; other site
742013000881	D-loop; other site
742013000882	H-loop/switch region; other site
742013000883	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
742013000884	Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_3; cd06336
742013000885	putative ligand binding site [chemical binding]; other site
742013000886	Plasmid maintenance system killer protein; Region: Plasmid_killer; cl01422
742013000887	Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093
742013000888	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
742013000889	sequence-specific DNA binding site [nucleotide binding]; other site
742013000890	salt bridge; other site
742013000891	gluconate 5-dehydrogenase; Provisional; Region: PRK08213
742013000892	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
742013000893	NAD(P) binding site [chemical binding]; other site
742013000894	active site
742013000895	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
742013000896	Transcriptional regulator [Transcription]; Region: IclR; COG1414
742013000897	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
742013000898	Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195
742013000899	FAD binding pocket [chemical binding]; other site
742013000900	FAD binding motif [chemical binding]; other site
742013000901	phosphate binding motif [ion binding]; other site
742013000902	beta-alpha-beta structure motif; other site
742013000903	NAD binding pocket [chemical binding]; other site
742013000904	Transcriptional regulator [Transcription]; Region: LysR; COG0583
742013000905	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
742013000906	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
742013000907	dimerization interface [polypeptide binding]; other site
742013000908	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
742013000909	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
742013000910	NAD(P) binding site [chemical binding]; other site
742013000911	active site
742013000912	Protein of unknown function (DUF3325); Region: DUF3325; pfam11804
742013000913	Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182
742013000914	PepSY-associated TM helix; Region: PepSY_TM_3; pfam13706
742013000915	PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703
742013000916	Transcriptional regulator [Transcription]; Region: LysR; COG0583
742013000917	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
742013000918	The C-terminal substrate domain of LysR-like regulator LrhA (LysR homologue A) and that of closely related homologs, contains the type 2 periplasmic binding fold; Region: PBP2_LrhA_like; cd08439
742013000919	putative dimerization interface [polypeptide binding]; other site
742013000920	Predicted metal-dependent enzyme of the double-stranded beta helix superfamily [General function prediction only]; Region: COG5553
742013000921	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
742013000922	active site residue [active]
742013000923	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
742013000924	active site residue [active]
742013000925	Member of the Rhodanese Homology Domain superfamily, repeat 3. This CD includes putative rhodanese-related sulfurtransferases which contain 4 copies of the Rhodanese Homology Domain. This CD aligns the 3rd repeat which does not contain the putative...; Region: 4RHOD_Repeat_3; cd01534
742013000926	active site residue [active]
742013000927	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
742013000928	active site residue [active]
742013000929	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
742013000930	Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626
742013000931	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
742013000932	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
742013000933	catalytic residue [active]
742013000934	Nitronate monooxygenase; Region: NMO; pfam03060
742013000935	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
742013000936	FMN binding site [chemical binding]; other site
742013000937	substrate binding site [chemical binding]; other site
742013000938	putative catalytic residue [active]
742013000939	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
742013000940	Major Facilitator Superfamily; Region: MFS_1; pfam07690
742013000941	putative substrate translocation pore; other site
742013000942	Transcriptional regulator [Transcription]; Region: LysR; COG0583
742013000943	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
742013000944	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
742013000945	dimerization interface [polypeptide binding]; other site
742013000946	Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606
742013000947	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
742013000948	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078
742013000949	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335
742013000950	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
742013000951	RHS Repeat; Region: RHS_repeat; pfam05593
742013000952	RHS Repeat; Region: RHS_repeat; pfam05593
742013000953	RHS protein; Region: RHS; pfam03527
742013000954	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
742013000955	Repeat domain of CamS sex pheromone cAM373 precursor and related proteins; Region: CamS_repeat; cl17505
742013000956	Class II hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase_classII; cd00644
742013000957	homodimer interface [polypeptide binding]; other site
742013000958	catalytic residues [active]
742013000959	NAD binding site [chemical binding]; other site
742013000960	substrate binding pocket [chemical binding]; other site
742013000961	flexible flap; other site
742013000962	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
742013000963	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
742013000964	DNA-binding site [nucleotide binding]; DNA binding site
742013000965	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
742013000966	pyridoxal 5'-phosphate binding site [chemical binding]; other site
742013000967	homodimer interface [polypeptide binding]; other site
742013000968	catalytic residue [active]
742013000969	pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424
742013000970	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
742013000971	The C-terminal substrate binding domain of galactose-binding protein regulator contains the type 2 periplasmic binding fold; Region: PBP2_GbpR; cd08435
742013000972	putative dimerization interface [polypeptide binding]; other site
742013000973	4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332
742013000974	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
742013000975	putative substrate translocation pore; other site
742013000976	L-rhamnonate dehydratase; Provisional; Region: PRK15440
742013000977	Mandelate racemase (MR)-like subfamily of the enolase superfamily, subgroup 2. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic...; Region: MR_like_2; cd03327
742013000978	putative active site pocket [active]
742013000979	putative metal binding site [ion binding]; other site
742013000980	2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase [Carbohydrate transport and metabolism]; Region: HpcH; COG3836
742013000981	Escherichia coli lactaldehyde dehydrogenase AldA-like; Region: ALDH_LactADH-AldA; cd07088
742013000982	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
742013000983	NAD binding site [chemical binding]; other site
742013000984	catalytic residues [active]
742013000985	substrate binding site [chemical binding]; other site
742013000986	Transcriptional regulators [Transcription]; Region: MarR; COG1846
742013000987	MarR family; Region: MarR_2; cl17246
742013000988	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
742013000989	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
742013000990	Sulfatase; Region: Sulfatase; pfam00884
742013000991	Domain of unknown function (DUF4034); Region: DUF4034; pfam13226
742013000992	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
742013000993	RHS Repeat; Region: RHS_repeat; pfam05593
742013000994	RHS Repeat; Region: RHS_repeat; pfam05593
742013000995	RHS Repeat; Region: RHS_repeat; cl11982
742013000996	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
742013000997	RHS protein; Region: RHS; pfam03527
742013000998	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
742013000999	type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361
742013001000	Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954
742013001001	Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717
742013001002	Gp5 C-terminal repeat (3 copies); Region: Gp5_C; pfam06715
742013001003	Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; cl01733
742013001004	Bacterial protein of unknown function (Gcw_chp); Region: Gcw_chp; cl09901
742013001005	Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347
742013001006	Nitrogen regulatory protein P-II; Region: P-II; smart00938
742013001007	Ammonium Transporter Family; Region: Ammonium_transp; cl03012
742013001008	Phage derived protein Gp49-like (DUF891); Region: Gp49; cl01470
742013001009	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
742013001010	non-specific DNA binding site [nucleotide binding]; other site
742013001011	salt bridge; other site
742013001012	sequence-specific DNA binding site [nucleotide binding]; other site
742013001013	glycolate oxidase FAD binding subunit; Provisional; Region: glcE; PRK11282
742013001014	FAD binding domain; Region: FAD_binding_4; pfam01565
742013001015	Protein of unknown function (DUF1275); Region: DUF1275; pfam06912
742013001016	glycolate oxidase iron-sulfur subunit; Provisional; Region: glcF; PRK11274
742013001017	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
742013001018	Cysteine-rich domain; Region: CCG; pfam02754
742013001019	Cysteine-rich domain; Region: CCG; pfam02754
742013001020	ProQ/FINO family; Region: ProQ; pfam04352
742013001021	putative RNA binding sites [nucleotide binding]; other site
742013001022	AmiS/UreI family transporter; Region: AmiS_UreI; pfam02293
742013001023	lysophospholipid transporter LplT; Provisional; Region: PRK11195
742013001024	alanine racemase; Reviewed; Region: dadX; PRK03646
742013001025	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827
742013001026	active site
742013001027	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
742013001028	substrate binding site [chemical binding]; other site
742013001029	catalytic residues [active]
742013001030	dimer interface [polypeptide binding]; other site
742013001031	Transcriptional regulators [Transcription]; Region: MarR; COG1846
742013001032	MarR family; Region: MarR_2; pfam12802
742013001033	Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375
742013001034	Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193
742013001035	FAD binding pocket [chemical binding]; other site
742013001036	FAD binding motif [chemical binding]; other site
742013001037	phosphate binding motif [ion binding]; other site
742013001038	NAD binding pocket [chemical binding]; other site
742013001039	DNA repair protein RadA; Provisional; Region: PRK11823
742013001040	Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121
742013001041	Walker A motif/ATP binding site; other site
742013001042	ATP binding site [chemical binding]; other site
742013001043	Walker B motif; other site
742013001044	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
742013001045	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
742013001046	BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids  leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557
742013001047	homodimer interface [polypeptide binding]; other site
742013001048	substrate-cofactor binding pocket; other site
742013001049	catalytic residue [active]
742013001050	Zinc-finger domain; Region: zf-CHCC; cl01821
742013001051	Capsular polysaccharide synthesis protein; Region: Caps_synth; pfam05704
742013001052	Glycosyltransferase sugar-binding region containing DXD motif; Region: Gly_transf_sug; pfam04488
742013001053	Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307
742013001054	O-Antigen ligase; Region: Wzy_C; pfam04932
742013001055	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
742013001056	This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811
742013001057	putative ADP-binding pocket [chemical binding]; other site
742013001058	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
742013001059	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
742013001060	active site
742013001061	Glycosyltransferase sugar-binding region containing DXD motif; Region: Gly_transf_sug; pfam04488
742013001062	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
742013001063	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
742013001064	Coenzyme A binding pocket [chemical binding]; other site
742013001065	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
742013001066	dimerization interface [polypeptide binding]; other site
742013001067	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
742013001068	dimer interface [polypeptide binding]; other site
742013001069	phosphorylation site [posttranslational modification]
742013001070	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
742013001071	ATP binding site [chemical binding]; other site
742013001072	Mg2+ binding site [ion binding]; other site
742013001073	G-X-G motif; other site
742013001074	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
742013001075	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
742013001076	active site
742013001077	phosphorylation site [posttranslational modification]
742013001078	intermolecular recognition site; other site
742013001079	dimerization interface [polypeptide binding]; other site
742013001080	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
742013001081	DNA binding site [nucleotide binding]
742013001082	AmpG-like permease; Region: 2A0125; TIGR00901
742013001083	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
742013001084	Peptidase family M48; Region: Peptidase_M48; pfam01435
742013001085	Rhodococcus ruber 6-oxolauric acid dehydrogenase-like; Region: ALDH_CddD_SSP0762; cd07138
742013001086	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
742013001087	NAD binding site [chemical binding]; other site
742013001088	catalytic residues [active]
742013001089	Clavaminic acid synthetase (CAS) -like;  CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184
742013001090	Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175
742013001091	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
742013001092	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
742013001093	dimer interface [polypeptide binding]; other site
742013001094	conserved gate region; other site
742013001095	putative PBP binding loops; other site
742013001096	ABC-ATPase subunit interface; other site
742013001097	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
742013001098	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
742013001099	Walker A/P-loop; other site
742013001100	ATP binding site [chemical binding]; other site
742013001101	Q-loop/lid; other site
742013001102	ABC transporter signature motif; other site
742013001103	Walker B; other site
742013001104	D-loop; other site
742013001105	H-loop/switch region; other site
742013001106	TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122
742013001107	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
742013001108	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
742013001109	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
742013001110	ligand binding site [chemical binding]; other site
742013001111	flexible hinge region; other site
742013001112	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320
742013001113	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
742013001114	Double zinc ribbon; Region: DZR; pfam12773
742013001115	Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304
742013001116	NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288
742013001117	ligand binding site [chemical binding]; other site
742013001118	homodimer interface [polypeptide binding]; other site
742013001119	NAD(P) binding site [chemical binding]; other site
742013001120	trimer interface B [polypeptide binding]; other site
742013001121	trimer interface A [polypeptide binding]; other site
742013001122	Domain of unknown function (DUF3814); Region: DUF3814; pfam12769
742013001123	NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282
742013001124	NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233
742013001125	Post-segregation antitoxin CcdA; Region: CcdA; cl02188
742013001126	Neisseria meningitides Nape-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Nape_like_AP-endo; cd10281
742013001127	putative active site [active]
742013001128	putative catalytic site [active]
742013001129	putative DNA binding site [nucleotide binding]; other site
742013001130	putative phosphate binding site [ion binding]; other site
742013001131	metal binding site A [ion binding]; metal-binding site
742013001132	putative AP binding site [nucleotide binding]; other site
742013001133	putative metal binding site B [ion binding]; other site
742013001134	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
742013001135	active site
742013001136	membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family; Region: PQQ_membr_DH; TIGR03074
742013001137	Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280
742013001138	Trp docking motif [polypeptide binding]; other site
742013001139	putative active site [active]
742013001140	Nitroreductase-like family 2. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_2; cd02138
742013001141	putative FMN binding site [chemical binding]; other site
742013001142	D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790
742013001143	Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176
742013001144	ligand binding site [chemical binding]; other site
742013001145	NAD binding site [chemical binding]; other site
742013001146	tetramer interface [polypeptide binding]; other site
742013001147	catalytic site [active]
742013001148	C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901
742013001149	L-serine binding site [chemical binding]; other site
742013001150	ACT domain interface; other site
742013001151	CBS-domain-containing membrane protein [Signal transduction mechanisms]; Region: COG3448
742013001152	HPP family; Region: HPP; pfam04982
742013001153	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
742013001154	Beta-lactamase; Region: Beta-lactamase; pfam00144
742013001155	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
742013001156	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
742013001157	aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477
742013001158	GatB/GatE catalytic domain; Region: GatB_N; pfam02934
742013001159	GatB domain; Region: GatB_Yqey; smart00845
742013001160	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
742013001161	aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012
742013001162	aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034
742013001163	rod shape-determining protein MreB; Provisional; Region: PRK13927
742013001164	MreB and similar proteins; Region: MreB_like; cd10225
742013001165	nucleotide binding site [chemical binding]; other site
742013001166	Mg binding site [ion binding]; other site
742013001167	putative protofilament interaction site [polypeptide binding]; other site
742013001168	RodZ interaction site [polypeptide binding]; other site
742013001169	rod shape-determining protein MreC; Provisional; Region: PRK13922
742013001170	rod shape-determining protein MreC; Region: MreC; pfam04085
742013001171	Cell shape-determining protein [Cell envelope biogenesis, outer membrane]; Region: MreD; COG2891
742013001172	penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423
742013001173	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
742013001174	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
742013001175	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
742013001176	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
742013001177	Walker A/P-loop; other site
742013001178	ATP binding site [chemical binding]; other site
742013001179	Q-loop/lid; other site
742013001180	ABC transporter signature motif; other site
742013001181	Walker B; other site
742013001182	D-loop; other site
742013001183	H-loop/switch region; other site
742013001184	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
742013001185	dimer interface [polypeptide binding]; other site
742013001186	conserved gate region; other site
742013001187	putative PBP binding loops; other site
742013001188	ABC-ATPase subunit interface; other site
742013001189	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
742013001190	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
742013001191	substrate binding pocket [chemical binding]; other site
742013001192	membrane-bound complex binding site; other site
742013001193	hinge residues; other site
742013001194	hypothetical protein; Provisional; Region: PRK10621
742013001195	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
742013001196	choline dehydrogenase; Validated; Region: PRK02106
742013001197	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
742013001198	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
742013001199	Permease; Region: Permease; pfam02405
742013001200	ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127
742013001201	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
742013001202	Walker A/P-loop; other site
742013001203	ATP binding site [chemical binding]; other site
742013001204	Q-loop/lid; other site
742013001205	ABC transporter signature motif; other site
742013001206	Walker B; other site
742013001207	D-loop; other site
742013001208	H-loop/switch region; other site
742013001209	ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463
742013001210	mce related protein; Region: MCE; pfam02470
742013001211	hypothetical protein; Provisional; Region: PRK10428
742013001212	Hemerythrin; Region: Hemerythrin; cd12107
742013001213	Fe binding site [ion binding]; other site
742013001214	MarC family integral membrane protein; Region: MarC; cl00919
742013001215	Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412
742013001216	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
742013001217	active site
742013001218	NTP binding site [chemical binding]; other site
742013001219	metal binding triad [ion binding]; metal-binding site
742013001220	antibiotic binding site [chemical binding]; other site
742013001221	Uncharacterized conserved protein [Function unknown]; Region: COG2361
742013001222	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
742013001223	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
742013001224	active site
742013001225	phosphorylation site [posttranslational modification]
742013001226	intermolecular recognition site; other site
742013001227	dimerization interface [polypeptide binding]; other site
742013001228	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
742013001229	dimerization interface [polypeptide binding]; other site
742013001230	DNA binding residues [nucleotide binding]
742013001231	7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695
742013001232	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
742013001233	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
742013001234	ATP binding site [chemical binding]; other site
742013001235	Mg2+ binding site [ion binding]; other site
742013001236	G-X-G motif; other site
742013001237	Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598
742013001238	Thermotoga maritima CorA-like family; Region: TmCorA-like; cd12822
742013001239	oligomer interface [polypeptide binding]; other site
742013001240	metal binding site [ion binding]; metal-binding site
742013001241	metal binding site [ion binding]; metal-binding site
742013001242	putative Cl binding site [ion binding]; other site
742013001243	aspartate ring; other site
742013001244	basic sphincter; other site
742013001245	hydrophobic gate; other site
742013001246	periplasmic entrance; other site
742013001247	Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823
742013001248	dimer interface [polypeptide binding]; other site
742013001249	allosteric magnesium binding site [ion binding]; other site
742013001250	active site
742013001251	aspartate-rich active site metal binding site; other site
742013001252	Schiff base residues; other site
742013001253	Uncharacterized protein family (UPF0093); Region: UPF0093; pfam03653
742013001254	Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980
742013001255	dimer interface [polypeptide binding]; other site
742013001256	[2Fe-2S] cluster binding site [ion binding]; other site
742013001257	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
742013001258	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686
742013001259	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
742013001260	Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936
742013001261	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
742013001262	S17 interaction site [polypeptide binding]; other site
742013001263	S8 interaction site; other site
742013001264	16S rRNA interaction site [nucleotide binding]; other site
742013001265	streptomycin interaction site [chemical binding]; other site
742013001266	23S rRNA interaction site [nucleotide binding]; other site
742013001267	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
742013001268	30S ribosomal protein S7; Validated; Region: PRK05302
742013001269	elongation factor G; Reviewed; Region: PRK00007
742013001270	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
742013001271	G1 box; other site
742013001272	putative GEF interaction site [polypeptide binding]; other site
742013001273	GTP/Mg2+ binding site [chemical binding]; other site
742013001274	Switch I region; other site
742013001275	G2 box; other site
742013001276	G3 box; other site
742013001277	Switch II region; other site
742013001278	G4 box; other site
742013001279	G5 box; other site
742013001280	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
742013001281	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
742013001282	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
742013001283	elongation factor Tu; Reviewed; Region: PRK00049
742013001284	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
742013001285	G1 box; other site
742013001286	GEF interaction site [polypeptide binding]; other site
742013001287	GTP/Mg2+ binding site [chemical binding]; other site
742013001288	Switch I region; other site
742013001289	G2 box; other site
742013001290	G3 box; other site
742013001291	Switch II region; other site
742013001292	G4 box; other site
742013001293	G5 box; other site
742013001294	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
742013001295	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
742013001296	Antibiotic Binding Site [chemical binding]; other site
742013001297	30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596
742013001298	50S ribosomal protein L3; Validated; Region: rplC; PRK00001
742013001299	50S ribosomal protein L4; Provisional; Region: rplD; PRK05319
742013001300	50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738
742013001301	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
742013001302	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
742013001303	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
742013001304	30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357
742013001305	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
742013001306	putative translocon binding site; other site
742013001307	protein-rRNA interface [nucleotide binding]; other site
742013001308	30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310
742013001309	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
742013001310	G-X-X-G motif; other site
742013001311	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
742013001312	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
742013001313	23S rRNA interface [nucleotide binding]; other site
742013001314	5S rRNA interface [nucleotide binding]; other site
742013001315	putative antibiotic binding site [chemical binding]; other site
742013001316	L25 interface [polypeptide binding]; other site
742013001317	L27 interface [polypeptide binding]; other site
742013001318	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427
742013001319	23S rRNA interface [nucleotide binding]; other site
742013001320	putative translocon interaction site; other site
742013001321	signal recognition particle (SRP54) interaction site; other site
742013001322	L23 interface [polypeptide binding]; other site
742013001323	trigger factor interaction site; other site
742013001324	30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610
742013001325	Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013
742013001326	catalytic triad [active]
742013001327	dimer interface [polypeptide binding]; other site
742013001328	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
742013001329	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
742013001330	Coenzyme A binding pocket [chemical binding]; other site
742013001331	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859
742013001332	Cytochrome C' Region: Cytochrom_C_2; pfam01322
742013001333	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
742013001334	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
742013001335	catalytic residues [active]
742013001336	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025
742013001337	active pocket/dimerization site; other site
742013001338	active site
742013001339	phosphorylation site [posttranslational modification]
742013001340	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
742013001341	dimerization domain swap beta strand [polypeptide binding]; other site
742013001342	regulatory protein interface [polypeptide binding]; other site
742013001343	active site
742013001344	regulatory phosphorylation site [posttranslational modification]; other site
742013001345	Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080
742013001346	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
742013001347	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
742013001348	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
742013001349	lipoyl synthase; Provisional; Region: PRK05481
742013001350	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
742013001351	FeS/SAM binding site; other site
742013001352	lipoate-protein ligase B; Provisional; Region: PRK14346
742013001353	Protein of unknown function (DUF493); Region: DUF493; cl01102
742013001354	ATP synthase I chain; Region: ATP_synt_I; pfam03899
742013001355	F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356
742013001356	F0F1 ATP synthase subunit A; Validated; Region: PRK05815
742013001357	F0F1 ATP synthase subunit C; Validated; Region: PRK06876
742013001358	F0F1 ATP synthase subunit B; Validated; Region: PRK05759
742013001359	F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711
742013001360	F0F1 ATP synthase subunit delta; Validated; Region: PRK05758
742013001361	ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213
742013001362	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
742013001363	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
742013001364	F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
742013001365	beta subunit interaction interface [polypeptide binding]; other site
742013001366	Walker A motif; other site
742013001367	ATP binding site [chemical binding]; other site
742013001368	Walker B motif; other site
742013001369	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
742013001370	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
742013001371	core domain interface [polypeptide binding]; other site
742013001372	delta subunit interface [polypeptide binding]; other site
742013001373	epsilon subunit interface [polypeptide binding]; other site
742013001374	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
742013001375	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
742013001376	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
742013001377	alpha subunit interaction interface [polypeptide binding]; other site
742013001378	Walker A motif; other site
742013001379	ATP binding site [chemical binding]; other site
742013001380	Walker B motif; other site
742013001381	inhibitor binding site; inhibition site
742013001382	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
742013001383	F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571
742013001384	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
742013001385	gamma subunit interface [polypeptide binding]; other site
742013001386	epsilon subunit interface [polypeptide binding]; other site
742013001387	LBP interface [polypeptide binding]; other site
742013001388	Repair protein; Region: Repair_PSII; pfam04536
742013001389	Beta-propeller domains of methanol dehydrogenase type [General function prediction only]; Region: COG1512
742013001390	Repair protein; Region: Repair_PSII; pfam04536
742013001391	Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704
742013001392	Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG0429
742013001393	Protein of unknown function (DUF2946); Region: DUF2944; pfam11161
742013001394	Cytochrome c; Region: Cytochrom_C; cl11414
742013001395	copper/silver efflux system outer membrane protein CusC; Provisional; Region: PRK09837
742013001396	The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915
742013001397	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
742013001398	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
742013001399	HlyD family secretion protein; Region: HlyD_3; pfam13437
742013001400	DNA-binding transcriptional repressor AcrR; Provisional; Region: PRK10668
742013001401	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
742013001402	MAATS-type transcriptional repressor, C-terminal region; Region: TetR_C_2; pfam08361
742013001403	elongation factor Tu; Reviewed; Region: PRK00049
742013001404	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
742013001405	G1 box; other site
742013001406	GEF interaction site [polypeptide binding]; other site
742013001407	GTP/Mg2+ binding site [chemical binding]; other site
742013001408	Switch I region; other site
742013001409	G2 box; other site
742013001410	G3 box; other site
742013001411	Switch II region; other site
742013001412	G4 box; other site
742013001413	G5 box; other site
742013001414	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
742013001415	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
742013001416	Antibiotic Binding Site [chemical binding]; other site
742013001417	preprotein translocase subunit SecE; Reviewed; Region: secE; PRK05740
742013001418	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
742013001419	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
742013001420	putative homodimer interface [polypeptide binding]; other site
742013001421	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
742013001422	heterodimer interface [polypeptide binding]; other site
742013001423	homodimer interface [polypeptide binding]; other site
742013001424	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
742013001425	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
742013001426	23S rRNA interface [nucleotide binding]; other site
742013001427	L7/L12 interface [polypeptide binding]; other site
742013001428	putative thiostrepton binding site; other site
742013001429	L25 interface [polypeptide binding]; other site
742013001430	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
742013001431	mRNA/rRNA interface [nucleotide binding]; other site
742013001432	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
742013001433	23S rRNA interface [nucleotide binding]; other site
742013001434	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
742013001435	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
742013001436	peripheral dimer interface [polypeptide binding]; other site
742013001437	core dimer interface [polypeptide binding]; other site
742013001438	L10 interface [polypeptide binding]; other site
742013001439	L11 interface [polypeptide binding]; other site
742013001440	putative EF-Tu interaction site [polypeptide binding]; other site
742013001441	putative EF-G interaction site [polypeptide binding]; other site
742013001442	DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405
742013001443	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
742013001444	RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561
742013001445	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
742013001446	RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562
742013001447	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
742013001448	RPB3 interaction site [polypeptide binding]; other site
742013001449	RPB1 interaction site [polypeptide binding]; other site
742013001450	RPB11 interaction site [polypeptide binding]; other site
742013001451	RPB10 interaction site [polypeptide binding]; other site
742013001452	DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086
742013001453	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
742013001454	RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663
742013001455	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
742013001456	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
742013001457	RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998
742013001458	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
742013001459	Rpb1 - Rpb6 interaction site [polypeptide binding]; other site
742013001460	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
742013001461	DNA binding site [nucleotide binding]
742013001462	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
742013001463	16S rRNA methyltransferase B; Provisional; Region: PRK10901
742013001464	RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223
742013001465	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
742013001466	S-adenosylmethionine binding site [chemical binding]; other site
742013001467	Domain of unknown function (DUF4390); Region: DUF4390; pfam14334
742013001468	Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms]; Region: NtrY; COG5000
742013001469	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
742013001470	dimerization interface [polypeptide binding]; other site
742013001471	PAS domain; Region: PAS; smart00091
742013001472	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
742013001473	dimer interface [polypeptide binding]; other site
742013001474	phosphorylation site [posttranslational modification]
742013001475	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
742013001476	ATP binding site [chemical binding]; other site
742013001477	Mg2+ binding site [ion binding]; other site
742013001478	G-X-G motif; other site
742013001479	Response regulator receiver domain; Region: Response_reg; pfam00072
742013001480	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
742013001481	active site
742013001482	phosphorylation site [posttranslational modification]
742013001483	intermolecular recognition site; other site
742013001484	dimerization interface [polypeptide binding]; other site
742013001485	Predicted transcriptional regulator [Transcription]; Region: COG3636; cl17681
742013001486	Cupin domain; Region: Cupin_2; pfam07883
742013001487	NnrS protein; Region: NnrS; pfam05940
742013001488	Transcriptional regulator; Region: Rrf2; cl17282
742013001489	Rrf2 family protein; Region: rrf2_super; TIGR00738
742013001490	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3399
742013001491	exonuclease V subunit gamma; Provisional; Region: recC; PRK11069
742013001492	Exodeoxyribonuclease V, gamma subunit; Region: Exonuc_V_gamma; pfam04257
742013001493	exonuclease V subunit gamma; Provisional; Region: recC; PRK11069
742013001494	ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains) [DNA replication, recombination, and repair]; Region: RecB; COG1074
742013001495	exonuclease V subunit alpha; Provisional; Region: recD; PRK10875
742013001496	AAA domain; Region: AAA_30; pfam13604
742013001497	Family description; Region: UvrD_C_2; pfam13538
742013001498	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
742013001499	Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of  glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570
742013001500	C-terminal domain interface [polypeptide binding]; other site
742013001501	GSH binding site (G-site) [chemical binding]; other site
742013001502	dimer interface [polypeptide binding]; other site
742013001503	C-terminal, alpha helical domain of an unknown subfamily 9 of Glutathione S-transferases; Region: GST_C_9; cd10424
742013001504	putative N-terminal domain interface [polypeptide binding]; other site
742013001505	putative dimer interface [polypeptide binding]; other site
742013001506	putative substrate binding pocket (H-site) [chemical binding]; other site
742013001507	Protein of unknown function (DUF461); Region: DUF461; pfam04314
742013001508	FIST N domain; Region: FIST; pfam08495
742013001509	FIST C domain; Region: FIST_C; pfam10442
742013001510	D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711
742013001511	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
742013001512	Bacterial Ig-like domain (group 1); Region: Big_1; cl17740
742013001513	Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182
742013001514	PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172
742013001515	Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369
742013001516	Flavodoxin; Region: Flavodoxin_1; pfam00258
742013001517	Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR_like1; cd06200
742013001518	FAD binding pocket [chemical binding]; other site
742013001519	FAD binding motif [chemical binding]; other site
742013001520	catalytic residues [active]
742013001521	NAD binding pocket [chemical binding]; other site
742013001522	phosphate binding motif [ion binding]; other site
742013001523	beta-alpha-beta structure motif; other site
742013001524	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4950; cl17731
742013001525	Carboxymuconolactone decarboxylase family; Region: CMD; cl00460
742013001526	uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926
742013001527	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
742013001528	FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454
742013001529	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
742013001530	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
742013001531	non-specific DNA binding site [nucleotide binding]; other site
742013001532	salt bridge; other site
742013001533	sequence-specific DNA binding site [nucleotide binding]; other site
742013001534	Major Facilitator Superfamily; Region: MFS_1; pfam07690
742013001535	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
742013001536	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
742013001537	putative acyl-acceptor binding pocket; other site
742013001538	Uncharacterized conserved protein [Function unknown]; Region: COG3268
742013001539	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
742013001540	NAD(P) binding site [chemical binding]; other site
742013001541	yiaA/B two helix domain; Region: YiaAB; cl01759
742013001542	yiaA/B two helix domain; Region: YiaAB; cl01759
742013001543	Uncharacterized protein conserved in bacteria (DUF2145); Region: DUF2145; pfam09916
742013001544	Putative zinc ribbon domain; Region: DUF164; pfam02591
742013001545	Double zinc ribbon; Region: DZR; pfam12773
742013001546	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
742013001547	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
742013001548	metal binding site [ion binding]; metal-binding site
742013001549	active site
742013001550	I-site; other site
742013001551	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
742013001552	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
742013001553	metal binding site [ion binding]; metal-binding site
742013001554	active site
742013001555	I-site; other site
742013001556	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
742013001557	Arylsulfotransferase (ASST); Region: Arylsulfotrans; pfam05935
742013001558	Transcriptional regulator [Transcription]; Region: LysR; COG0583
742013001559	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
742013001560	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
742013001561	dimerization interface [polypeptide binding]; other site
742013001562	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112
742013001563	Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343
742013001564	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
742013001565	Ligand Binding Site [chemical binding]; other site
742013001566	Phospholipase A1; Region: PLA1; pfam02253
742013001567	substrate binding site [chemical binding]; other site
742013001568	dimerization interface [polypeptide binding]; other site
742013001569	active site
742013001570	calcium binding site [ion binding]; other site
742013001571	ATP-dependent DNA helicase Rep; Region: rep; TIGR01074
742013001572	Part of AAA domain; Region: AAA_19; pfam13245
742013001573	Family description; Region: UvrD_C_2; pfam13538
742013001574	membrane glycoprotein; Provisional; Region: PHA03332
742013001575	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882
742013001576	G1 box; other site
742013001577	GTP/Mg2+ binding site [chemical binding]; other site
742013001578	G2 box; other site
742013001579	Switch I region; other site
742013001580	G3 box; other site
742013001581	Switch II region; other site
742013001582	G4 box; other site
742013001583	Predicted permeases [General function prediction only]; Region: COG0679
742013001584	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231
742013001585	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
742013001586	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
742013001587	Ligand binding site; other site
742013001588	Putative Catalytic site; other site
742013001589	DXD motif; other site
742013001590	GtrA-like protein; Region: GtrA; pfam04138
742013001591	uncharacterized YdjC-like family proteins from bacteria; Region: YdjC_like_3; cd10807
742013001592	putative active site [active]
742013001593	YdjC motif; other site
742013001594	Mg binding site [ion binding]; other site
742013001595	putative homodimer interface [polypeptide binding]; other site
742013001596	Bacterial L-asparaginases and related enzymes; Region: L-asparaginase_like; cd00411
742013001597	homodimer interface [polypeptide binding]; other site
742013001598	active site
742013001599	primosome assembly protein PriA; Validated; Region: PRK05580
742013001600	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
742013001601	ATP binding site [chemical binding]; other site
742013001602	putative Mg++ binding site [ion binding]; other site
742013001603	helicase superfamily c-terminal domain; Region: HELICc; smart00490
742013001604	Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717
742013001605	substrate binding site [chemical binding]; other site
742013001606	active site
742013001607	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181
742013001608	enoyl-CoA hydratase; Provisional; Region: PRK08140
742013001609	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
742013001610	substrate binding site [chemical binding]; other site
742013001611	oxyanion hole (OAH) forming residues; other site
742013001612	trimer interface [polypeptide binding]; other site
742013001613	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
742013001614	CoenzymeA binding site [chemical binding]; other site
742013001615	subunit interaction site [polypeptide binding]; other site
742013001616	PHB binding site; other site
742013001617	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
742013001618	phenylacetate-CoA ligase; Region: PA_CoA_ligase; TIGR02155
742013001619	acyl-activating enzyme (AAE) consensus motif; other site
742013001620	AMP binding site [chemical binding]; other site
742013001621	active site
742013001622	CoA binding site [chemical binding]; other site
742013001623	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
742013001624	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
742013001625	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
742013001626	Type I periplasmic binding component of ABC (ATPase Binding Cassette)-type transport systems that are predicted to be involved in uptake of amino acids; Region: PBP1_ABC-type_HAAT_like; cd06333
742013001627	putative ligand binding site [chemical binding]; other site
742013001628	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
742013001629	TM-ABC transporter signature motif; other site
742013001630	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
742013001631	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
742013001632	TM-ABC transporter signature motif; other site
742013001633	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
742013001634	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
742013001635	Walker A/P-loop; other site
742013001636	ATP binding site [chemical binding]; other site
742013001637	Q-loop/lid; other site
742013001638	ABC transporter signature motif; other site
742013001639	Walker B; other site
742013001640	D-loop; other site
742013001641	H-loop/switch region; other site
742013001642	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
742013001643	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
742013001644	Walker A/P-loop; other site
742013001645	ATP binding site [chemical binding]; other site
742013001646	Q-loop/lid; other site
742013001647	ABC transporter signature motif; other site
742013001648	Walker B; other site
742013001649	D-loop; other site
742013001650	H-loop/switch region; other site
742013001651	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
742013001652	Protein of unknown function (DUF2783); Region: DUF2783; pfam10932
742013001653	FAD-dependent oxidoreductase; Provisional; Region: PRK08132
742013001654	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
742013001655	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
742013001656	IclR helix-turn-helix domain; Region: HTH_IclR; cl17605
742013001657	Transcriptional regulator [Transcription]; Region: IclR; COG1414
742013001658	Bacterial transcriptional regulator; Region: IclR; pfam01614
742013001659	Cache domain; Region: Cache_1; pfam02743
742013001660	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
742013001661	dimerization interface [polypeptide binding]; other site
742013001662	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
742013001663	dimer interface [polypeptide binding]; other site
742013001664	Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015
742013001665	putative CheW interface [polypeptide binding]; other site
742013001666	Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; cl17496
742013001667	Predicted CoA-binding protein [General function prediction only]; Region: COG1832
742013001668	Na+/H+ antiporter [Inorganic ion transport and metabolism]; Region: NhaA; COG3004
742013001669	Disulphide bond corrector protein DsbC; Region: DsbC; cl15830
742013001670	Thiol:disulfide interchange protein [Posttranslational modification, protein turnover, chaperones / Energy production and conversion]; Region: COG4232
742013001671	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788
742013001672	DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953
742013001673	DsbD alpha interface [polypeptide binding]; other site
742013001674	catalytic residues [active]
742013001675	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
742013001676	Creatinine amidohydrolase; Region: Creatininase; pfam02633
742013001677	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
742013001678	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
742013001679	catalytic core [active]
742013001680	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
742013001681	Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384
742013001682	Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436
742013001683	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
742013001684	pyridoxal 5'-phosphate binding site [chemical binding]; other site
742013001685	homodimer interface [polypeptide binding]; other site
742013001686	catalytic residue [active]
742013001687	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
742013001688	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
742013001689	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
742013001690	DNA-binding site [nucleotide binding]; DNA binding site
742013001691	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
742013001692	pyridoxal 5'-phosphate binding site [chemical binding]; other site
742013001693	homodimer interface [polypeptide binding]; other site
742013001694	catalytic residue [active]
742013001695	flagellar biosynthesis sigma factor; Validated; Region: fliA; PRK06986
742013001696	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
742013001697	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
742013001698	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
742013001699	DNA binding residues [nucleotide binding]
742013001700	flagellar biosynthesis regulator FlhF; Validated; Region: flhF; PRK06995
742013001701	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
742013001702	flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012
742013001703	FHIPEP family; Region: FHIPEP; pfam00771
742013001704	flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702
742013001705	Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257
742013001706	Chemotaxis phosphatase, CheZ; Region: CheZ; pfam04344
742013001707	chemotaxis regulatory protein CheY; Provisional; Region: PRK10610
742013001708	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
742013001709	active site
742013001710	phosphorylation site [posttranslational modification]
742013001711	intermolecular recognition site; other site
742013001712	dimerization interface [polypeptide binding]; other site
742013001713	Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677
742013001714	Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360
742013001715	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
742013001716	ligand binding site [chemical binding]; other site
742013001717	Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291
742013001718	flagellar motor stator protein MotA; Region: MotA1; TIGR03818
742013001719	UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511
742013001720	putative metal binding site; other site
742013001721	Tetratricopeptide repeat; Region: TPR_12; pfam13424
742013001722	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
742013001723	TPR motif; other site
742013001724	binding surface
742013001725	flagellin; Provisional; Region: PRK12802
742013001726	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
742013001727	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
742013001728	flagellin; Provisional; Region: PRK12802
742013001729	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
742013001730	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
742013001731	flagellin; Provisional; Region: PRK12802
742013001732	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
742013001733	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
742013001734	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4627
742013001735	Methyltransferase domain; Region: Methyltransf_23; pfam13489
742013001736	flagellin; Provisional; Region: PRK12802
742013001737	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
742013001738	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
742013001739	flagellar capping protein; Reviewed; Region: fliD; PRK08032
742013001740	Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465
742013001741	Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195
742013001742	Flagellar protein FliS; Region: FliS; cl00654
742013001743	Flagellar protein FliT; Region: FliT; pfam05400
742013001744	Predicted signal transduction protein containing EAL and modified HD-GYP domains [Signal transduction mechanisms]; Region: COG3434
742013001745	flagellar hook-associated protein FlgL; Reviewed; Region: flgL; PRK08870
742013001746	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
742013001747	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
742013001748	flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK06945
742013001749	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
742013001750	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
742013001751	Rod binding protein; Region: Rod-binding; cl01626
742013001752	flagellar rod assembly protein/muramidase FlgJ; Region: flagell_FlgJ; TIGR02541
742013001753	Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; pfam01832
742013001754	flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622
742013001755	flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303
742013001756	Flagellar basal body L-ring protein [Cell motility and secretion]; Region: FlgH; COG2063
742013001757	Flagellar L-ring protein; Region: FlgH; pfam02107
742013001758	flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693
742013001759	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
742013001760	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
742013001761	flagellar basal body rod protein FlgF; Reviewed; Region: flgF; PRK12640
742013001762	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
742013001763	flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490
742013001764	flagellar hook protein FlgE; Validated; Region: flgE; PRK05682
742013001765	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
742013001766	Flagellar basal body protein FlaE; Region: FlaE; pfam07559
742013001767	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
742013001768	Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963
742013001769	flagellar basal body rod modification protein; Reviewed; Region: flgD; PRK06655
742013001770	FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861
742013001771	flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681
742013001772	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
742013001773	flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680
742013001774	flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182
742013001775	SAF-like; Region: SAF_2; pfam13144
742013001776	SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614
742013001777	Domains similar to fish antifreeze type III protein; Region: SAF; cl00555
742013001778	flagellar biosynthesis anti-sigma factor FlgM; Region: FlgM_jcvi; TIGR03824
742013001779	Flagellar hook-basal body complex protein FliE; Region: FliE; cl09139
742013001780	flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007
742013001781	Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907
742013001782	Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345
742013001783	flagellar motor switch protein G; Validated; Region: fliG; PRK05686
742013001784	FliG C-terminal domain; Region: FliG_C; pfam01706
742013001785	Flagellar assembly protein FliH; Region: FliH; pfam02108
742013001786	flagellar protein export ATPase FliI; Region: FliI_clade1; TIGR03496
742013001787	Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136
742013001788	Walker A motif/ATP binding site; other site
742013001789	Walker B motif; other site
742013001790	flagellar biosynthesis chaperone; Validated; Region: fliJ; PRK05689
742013001791	Flagellar FliJ protein; Region: FliJ; pfam02050
742013001792	Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120
742013001793	Flagellar basal body-associated protein FliL; Region: FliL; cl00681
742013001794	flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666
742013001795	Surface presentation of antigens (SPOA); Region: SpoA; pfam01052
742013001796	flagellar motor switch protein; Validated; Region: fliN; PRK05698
742013001797	Surface presentation of antigens (SPOA); Region: SpoA; cl00819
742013001798	Flagellar biosynthesis protein, FliO; Region: FliO; pfam04347
742013001799	flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699
742013001800	flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700
742013001801	flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701
742013001802	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
742013001803	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
742013001804	active site
742013001805	phosphorylation site [posttranslational modification]
742013001806	intermolecular recognition site; other site
742013001807	dimerization interface [polypeptide binding]; other site
742013001808	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
742013001809	DNA binding residues [nucleotide binding]
742013001810	dimerization interface [polypeptide binding]; other site
742013001811	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
742013001812	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
742013001813	active site
742013001814	phosphorylation site [posttranslational modification]
742013001815	intermolecular recognition site; other site
742013001816	dimerization interface [polypeptide binding]; other site
742013001817	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
742013001818	Histidine kinase; Region: HisKA_3; pfam07730
742013001819	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
742013001820	ATP binding site [chemical binding]; other site
742013001821	Mg2+ binding site [ion binding]; other site
742013001822	G-X-G motif; other site
742013001823	Response regulator receiver domain; Region: Response_reg; pfam00072
742013001824	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
742013001825	active site
742013001826	phosphorylation site [posttranslational modification]
742013001827	intermolecular recognition site; other site
742013001828	dimerization interface [polypeptide binding]; other site
742013001829	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
742013001830	putative binding surface; other site
742013001831	active site
742013001832	Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895
742013001833	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
742013001834	ATP binding site [chemical binding]; other site
742013001835	Mg2+ binding site [ion binding]; other site
742013001836	G-X-G motif; other site
742013001837	CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731
742013001838	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256
742013001839	chemotaxis methyltransferase CheR; Provisional; Region: PRK10611
742013001840	CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705
742013001841	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
742013001842	chemoreceptor glutamine deamidase CheD; Provisional; Region: PRK13487
742013001843	chemotaxis-specific methylesterase; Provisional; Region: PRK00742
742013001844	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
742013001845	active site
742013001846	phosphorylation site [posttranslational modification]
742013001847	intermolecular recognition site; other site
742013001848	dimerization interface [polypeptide binding]; other site
742013001849	CheB methylesterase; Region: CheB_methylest; pfam01339
742013001850	ABC transporter ATPase component; Reviewed; Region: PRK11147
742013001851	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
742013001852	Walker A/P-loop; other site
742013001853	ATP binding site [chemical binding]; other site
742013001854	Q-loop/lid; other site
742013001855	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
742013001856	ABC transporter signature motif; other site
742013001857	Walker B; other site
742013001858	ABC transporter; Region: ABC_tran_2; pfam12848
742013001859	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
742013001860	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
742013001861	Helix-Turn-Helix DNA binding domain of the regulatory protein GnyR; Region: HTH_GnyR; cd04776
742013001862	DNA binding residues [nucleotide binding]
742013001863	putative dimer interface [polypeptide binding]; other site
742013001864	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
742013001865	CoenzymeA binding site [chemical binding]; other site
742013001866	subunit interaction site [polypeptide binding]; other site
742013001867	PHB binding site; other site
742013001868	Isovaleryl-CoA dehydrogenase; Region: IVD; cd01156
742013001869	isovaleryl-CoA dehydrogenase; Region: PLN02519
742013001870	substrate binding site [chemical binding]; other site
742013001871	FAD binding site [chemical binding]; other site
742013001872	catalytic base [active]
742013001873	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883
742013001874	active site clefts [active]
742013001875	zinc binding site [ion binding]; other site
742013001876	dimer interface [polypeptide binding]; other site
742013001877	Isocitrate dehydrogenase kinase/phosphatase [Signal transduction mechanisms]; Region: COG4579
742013001878	bifunctional isocitrate dehydrogenase kinase/phosphatase protein; Validated; Region: aceK; PRK02946
742013001879	acetyl-CoA acetyltransferase; Provisional; Region: PRK06954
742013001880	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
742013001881	dimer interface [polypeptide binding]; other site
742013001882	active site
742013001883	PPOX class probable FMN-dependent enzyme, DR_2398 family; Region: PPOX_FMN_DR2398; TIGR04025
742013001884	short chain dehydrogenase; Provisional; Region: PRK06953
742013001885	C factor cell-cell signaling protein; Provisional; Region: PRK09009
742013001886	NAD(P) binding site [chemical binding]; other site
742013001887	active site
742013001888	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
742013001889	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
742013001890	active site
742013001891	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
742013001892	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
742013001893	catalytic site [active]
742013001894	TAP-like protein; Region: Abhydrolase_4; pfam08386
742013001895	Predicted membrane protein [Function unknown]; Region: COG2323
742013001896	hypothetical protein; Provisional; Region: PRK01842
742013001897	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
742013001898	dimer interface [polypeptide binding]; other site
742013001899	phosphorylation site [posttranslational modification]
742013001900	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
742013001901	Mg2+ binding site [ion binding]; other site
742013001902	G-X-G motif; other site
742013001903	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
742013001904	Response regulator receiver domain; Region: Response_reg; pfam00072
742013001905	active site
742013001906	phosphorylation site [posttranslational modification]
742013001907	intermolecular recognition site; other site
742013001908	dimerization interface [polypeptide binding]; other site
742013001909	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
742013001910	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
742013001911	active site
742013001912	phosphorylation site [posttranslational modification]
742013001913	intermolecular recognition site; other site
742013001914	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
742013001915	DNA binding residues [nucleotide binding]
742013001916	dimerization interface [polypeptide binding]; other site
742013001917	glycine reductase, selenoprotein B; Region: gly_red_sel_B; TIGR01917
742013001918	Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637
742013001919	GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046
742013001920	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
742013001921	putative C-terminal domain interface [polypeptide binding]; other site
742013001922	putative GSH binding site (G-site) [chemical binding]; other site
742013001923	putative dimer interface [polypeptide binding]; other site
742013001924	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776
742013001925	N-terminal domain interface [polypeptide binding]; other site
742013001926	dimer interface [polypeptide binding]; other site
742013001927	substrate binding pocket (H-site) [chemical binding]; other site
742013001928	Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625
742013001929	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
742013001930	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
742013001931	AMP-binding domain protein; Validated; Region: PRK08315
742013001932	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
742013001933	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
742013001934	Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917
742013001935	acyl-activating enzyme (AAE) consensus motif; other site
742013001936	acyl-activating enzyme (AAE) consensus motif; other site
742013001937	putative AMP binding site [chemical binding]; other site
742013001938	putative active site [active]
742013001939	putative CoA binding site [chemical binding]; other site
742013001940	Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831
742013001941	3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820
742013001942	enoyl-CoA hydratase; Provisional; Region: PRK05995
742013001943	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
742013001944	substrate binding site [chemical binding]; other site
742013001945	oxyanion hole (OAH) forming residues; other site
742013001946	trimer interface [polypeptide binding]; other site
742013001947	Domain of unknown function (DUF4126); Region: DUF4126; pfam13548
742013001948	Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770
742013001949	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
742013001950	ATP-grasp domain; Region: ATP-grasp_4; cl17255
742013001951	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
742013001952	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
742013001953	carboxyltransferase (CT) interaction site; other site
742013001954	biotinylation site [posttranslational modification]; other site
742013001955	Putative glycerate dehydrogenase and related proteins of the D-specific 2-hydroxy dehydrogenase family; Region: GDH_like_2; cd12164
742013001956	bifunctional glyoxylate/hydroxypyruvate reductase A; Provisional; Region: ghrA; PRK15469
742013001957	putative ligand binding site [chemical binding]; other site
742013001958	NAD binding site [chemical binding]; other site
742013001959	dimerization interface [polypeptide binding]; other site
742013001960	catalytic site [active]
742013001961	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
742013001962	Prokaryotic protein of unknown function (DUF849); Region: DUF849; pfam05853
742013001963	3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK06130
742013001964	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
742013001965	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
742013001966	Transcriptional regulator [Transcription]; Region: LysR; COG0583
742013001967	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
742013001968	TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440
742013001969	putative dimerization interface [polypeptide binding]; other site
742013001970	Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119
742013001971	3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938
742013001972	active site
742013001973	catalytic residues [active]
742013001974	metal binding site [ion binding]; metal-binding site
742013001975	This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens  ProX Ala-tRNA(Pro)...; Region: ProX_deacylase; cd04333
742013001976	putative deacylase active site [active]
742013001977	Protein of unknown function (DUF1289); Region: DUF1289; pfam06945
742013001978	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
742013001979	DsbA family, 2-hydroxychromene-2-carboxylate (HCCA) isomerase subfamily; HCCA isomerase is a glutathione (GSH) dependent enzyme involved in the naphthalene catabolic pathway. It converts HCCA, a hemiketal formed spontaneously after ring cleavage of 1; Region: DsbA_HCCA_Iso; cd03022
742013001980	putative catalytic residue [active]
742013001981	Predicted signal-transduction protein containing cAMP-binding and CBS domains [Signal transduction mechanisms]; Region: COG2905
742013001982	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
742013001983	ligand binding site [chemical binding]; other site
742013001984	flexible hinge region; other site
742013001985	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
742013001986	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
742013001987	metal binding triad; other site
742013001988	DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847
742013001989	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
742013001990	active site
742013001991	catalytic site [active]
742013001992	substrate binding site [chemical binding]; other site
742013001993	PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865
742013001994	substrate binding site [chemical binding]; other site
742013001995	Predicted symporter [General function prediction only]; Region: DhlC; COG4147
742013001996	Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480
742013001997	Na binding site [ion binding]; other site
742013001998	Protein of unknown function, DUF485; Region: DUF485; pfam04341
742013001999	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
742013002000	putative substrate translocation pore; other site
742013002001	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
742013002002	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
742013002003	trimer interface [polypeptide binding]; other site
742013002004	eyelet of channel; other site
742013002005	Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178
742013002006	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
742013002007	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
742013002008	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
742013002009	Walker A/P-loop; other site
742013002010	ATP binding site [chemical binding]; other site
742013002011	Q-loop/lid; other site
742013002012	ABC transporter signature motif; other site
742013002013	Walker B; other site
742013002014	D-loop; other site
742013002015	H-loop/switch region; other site
742013002016	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
742013002017	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
742013002018	Walker A/P-loop; other site
742013002019	ATP binding site [chemical binding]; other site
742013002020	Q-loop/lid; other site
742013002021	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
742013002022	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
742013002023	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
742013002024	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
742013002025	putative substrate translocation pore; other site
742013002026	Transcriptional regulator [Transcription]; Region: LysR; COG0583
742013002027	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
742013002028	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
742013002029	dimerization interface [polypeptide binding]; other site
742013002030	metabolite-proton symporter; Region: 2A0106; TIGR00883
742013002031	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
742013002032	putative substrate translocation pore; other site
742013002033	choline dehydrogenase; Validated; Region: PRK02106
742013002034	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
742013002035	Transcriptional regulator [Transcription]; Region: IclR; COG1414
742013002036	IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339
742013002037	Bacterial transcriptional regulator; Region: IclR; pfam01614
742013002038	DctM-like transporters; Region: DctM; pfam06808
742013002039	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593
742013002040	TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090
742013002041	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
742013002042	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480
742013002043	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200
742013002044	Phage-related protein [Function unknown]; Region: COG4679
742013002045	Predicted symporter [General function prediction only]; Region: DhlC; COG4147
742013002046	Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475
742013002047	Na binding site [ion binding]; other site
742013002048	trifunctional transcriptional regulator/proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: putA; PRK11809
742013002049	Predicted transcriptional regulator [Transcription]; Region: COG3905
742013002050	Proline dehydrogenase [Amino acid transport and metabolism]; Region: PutA; COG0506
742013002051	Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125
742013002052	Glutamate binding site [chemical binding]; other site
742013002053	NAD binding site [chemical binding]; other site
742013002054	catalytic residues [active]
742013002055	P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188
742013002056	PapC N-terminal domain; Region: PapC_N; pfam13954
742013002057	Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577
742013002058	PapC C-terminal domain; Region: PapC_C; pfam13953
742013002059	fimbrial assembly chaperone SthB; Provisional; Region: PRK15295
742013002060	Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345
742013002061	Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753
742013002062	P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539
742013002063	HAD-superfamily hydrolase, subfamily IIB; Region: HAD-SF-IIB; TIGR01484
742013002064	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915
742013002065	motif II; other site
742013002066	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
742013002067	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
742013002068	Ligand binding site; other site
742013002069	Putative Catalytic site; other site
742013002070	DXD motif; other site
742013002071	4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnE; Provisional; Region: PRK15051
742013002072	HTH-like domain; Region: HTH_21; pfam13276
742013002073	Integrase core domain; Region: rve; pfam00665
742013002074	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
742013002075	peptide chain release factor 3; Provisional; Region: prfC; PRK00741
742013002076	Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169
742013002077	G1 box; other site
742013002078	putative GEF interaction site [polypeptide binding]; other site
742013002079	GTP/Mg2+ binding site [chemical binding]; other site
742013002080	Switch I region; other site
742013002081	G2 box; other site
742013002082	G3 box; other site
742013002083	Switch II region; other site
742013002084	G4 box; other site
742013002085	G5 box; other site
742013002086	Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787
742013002087	F subunit of K+-transporting ATPase (Potass_KdpF); Region: Potass_KdpF; pfam09604
742013002088	potassium-transporting ATPase subunit A; Provisional; Region: PRK05482
742013002089	K+-transporting ATPase, c chain [Inorganic ion transport and metabolism]; Region: KdpC; COG2156
742013002090	potassium-transporting ATPase subunit B; Provisional; Region: PRK01122
742013002091	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
742013002092	Bacterial protein of unknown function (Gcw_chp); Region: Gcw_chp; cl09901
742013002093	Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205
742013002094	Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702
742013002095	USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987
742013002096	Ligand Binding Site [chemical binding]; other site
742013002097	Domain of unknown function (DUF4118); Region: DUF4118; pfam13493
742013002098	GAF domain; Region: GAF_3; pfam13492
742013002099	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
742013002100	dimer interface [polypeptide binding]; other site
742013002101	phosphorylation site [posttranslational modification]
742013002102	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
742013002103	ATP binding site [chemical binding]; other site
742013002104	Mg2+ binding site [ion binding]; other site
742013002105	G-X-G motif; other site
742013002106	DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529
742013002107	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
742013002108	active site
742013002109	phosphorylation site [posttranslational modification]
742013002110	intermolecular recognition site; other site
742013002111	dimerization interface [polypeptide binding]; other site
742013002112	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
742013002113	DNA binding site [nucleotide binding]
742013002114	S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476
742013002115	S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401
742013002116	homotetramer interface [polypeptide binding]; other site
742013002117	ligand binding site [chemical binding]; other site
742013002118	catalytic site [active]
742013002119	NAD binding site [chemical binding]; other site
742013002120	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
742013002121	FtsJ-like methyltransferase; Region: FtsJ; pfam01728
742013002122	FtsJ-like methyltransferase; Region: FtsJ; cl17430
742013002123	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537
742013002124	FAD binding site [chemical binding]; other site
742013002125	Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797
742013002126	Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330
742013002127	Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961
742013002128	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
742013002129	23S rRNA interface [nucleotide binding]; other site
742013002130	L3 interface [polypeptide binding]; other site
742013002131	30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132
742013002132	iron-sulfur cluster insertion protein ErpA; Provisional; Region: PRK13623
742013002133	putative transporter; Provisional; Region: PRK10504
742013002134	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
742013002135	putative substrate translocation pore; other site
742013002136	xanthine dehydrogenase, small subunit; Region: xanthine_xdhA; TIGR02963
742013002137	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
742013002138	CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450
742013002139	xanthine dehydrogenase, molybdopterin binding subunit; Region: xanthine_xdhB; TIGR02965
742013002140	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
742013002141	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
742013002142	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
742013002143	anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585
742013002144	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
742013002145	Peptidase family M23; Region: Peptidase_M23; pfam01551
742013002146	tyrosyl-tRNA synthetase; Validated; Region: PRK05912
742013002147	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
742013002148	active site
742013002149	HIGH motif; other site
742013002150	dimer interface [polypeptide binding]; other site
742013002151	KMSKS motif; other site
742013002152	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
742013002153	RNA binding surface [nucleotide binding]; other site
742013002154	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
742013002155	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
742013002156	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
742013002157	dimerization interface [polypeptide binding]; other site
742013002158	N-acetylglucosamine-1-phosphate uridyltransferase (contains nucleotidyltransferase and I-patch acetyltransferase domains) [Cell envelope biogenesis, outer membrane]; Region: GlmU; COG1207
742013002159	N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540
742013002160	Substrate binding site; other site
742013002161	Mg++ binding site; other site
742013002162	N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353
742013002163	active site
742013002164	substrate binding site [chemical binding]; other site
742013002165	CoA binding site [chemical binding]; other site
742013002166	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
742013002167	dimer interface [polypeptide binding]; other site
742013002168	phosphorylation site [posttranslational modification]
742013002169	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
742013002170	ATP binding site [chemical binding]; other site
742013002171	Mg2+ binding site [ion binding]; other site
742013002172	G-X-G motif; other site
742013002173	diguanylate cyclase AdrA; Provisional; Region: adrA; PRK10245
742013002174	MASE2 domain; Region: MASE2; pfam05230
742013002175	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
742013002176	metal binding site [ion binding]; metal-binding site
742013002177	active site
742013002178	I-site; other site
742013002179	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
742013002180	Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412
742013002181	AsnC family; Region: AsnC_trans_reg; pfam01037
742013002182	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
742013002183	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
742013002184	glutaminase active site [active]
742013002185	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
742013002186	dimer interface [polypeptide binding]; other site
742013002187	active site
742013002188	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
742013002189	dimer interface [polypeptide binding]; other site
742013002190	active site
742013002191	ferrichrome receptor precursor protein; Provisional; Region: PRK14050
742013002192	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
742013002193	N-terminal plug; other site
742013002194	ligand-binding site [chemical binding]; other site
742013002195	Secretin and TonB N terminus short domain; Region: STN; smart00965
742013002196	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
742013002197	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
742013002198	N-terminal plug; other site
742013002199	ligand-binding site [chemical binding]; other site
742013002200	fec operon regulator FecR; Reviewed; Region: PRK09774
742013002201	FecR protein; Region: FecR; pfam04773
742013002202	RNA polymerase sigma factor; Provisional; Region: PRK12528
742013002203	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
742013002204	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
742013002205	DNA binding residues [nucleotide binding]
742013002206	Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor...; Region: IPT; cd00102
742013002207	IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the...; Region: IPT_PCSR; cd00603
742013002208	Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor...; Region: IPT; cd00102
742013002209	DNA-binding transcriptional activator FeaR; Provisional; Region: PRK09685
742013002210	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
742013002211	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
742013002212	Predicted NAD/FAD-binding protein [General function prediction only]; Region: COG2907
742013002213	Protein of unknown function (DUF1365); Region: DUF1365; pfam07103
742013002214	Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230
742013002215	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
742013002216	S-adenosylmethionine binding site [chemical binding]; other site
742013002217	MFS/sugar transport protein; Region: MFS_2; pfam13347
742013002218	MFS/sugar transport protein; Region: MFS_2; pfam13347
742013002219	Protein of unknown function (DUF3833); Region: DUF3833; pfam12915
742013002220	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
742013002221	short chain dehydrogenase; Provisional; Region: PRK07024
742013002222	NAD(P) binding site [chemical binding]; other site
742013002223	active site
742013002224	SnoaL-like domain; Region: SnoaL_2; pfam12680
742013002225	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
742013002226	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
742013002227	DNA-binding site [nucleotide binding]; DNA binding site
742013002228	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
742013002229	pyridoxal 5'-phosphate binding site [chemical binding]; other site
742013002230	homodimer interface [polypeptide binding]; other site
742013002231	catalytic residue [active]
742013002232	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262
742013002233	Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384
742013002234	DinB family; Region: DinB; cl17821
742013002235	DinB superfamily; Region: DinB_2; pfam12867
742013002236	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
742013002237	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
742013002238	active site
742013002239	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
742013002240	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
742013002241	S-adenosylmethionine binding site [chemical binding]; other site
742013002242	GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929
742013002243	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
742013002244	active site
742013002245	alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400
742013002246	Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788
742013002247	active site
742013002248	homotetramer interface [polypeptide binding]; other site
742013002249	Trehalose-6-phosphatase [Carbohydrate transport and metabolism]; Region: OtsB; COG1877
742013002250	trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105
742013002251	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
742013002252	Ubiquinol oxidase subunit I.  Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662
742013002253	D-pathway; other site
742013002254	Putative ubiquinol binding site [chemical binding]; other site
742013002255	Low-spin heme (heme b) binding site [chemical binding]; other site
742013002256	Putative water exit pathway; other site
742013002257	Binuclear center (heme o3/CuB) [ion binding]; other site
742013002258	K-pathway; other site
742013002259	Putative proton exit pathway; other site
742013002260	Heme-copper oxidase subunit III.  Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cl00211
742013002261	Subunit I/III interface [polypeptide binding]; other site
742013002262	Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622
742013002263	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
742013002264	Cytochrome c; Region: Cytochrom_C; pfam00034
742013002265	Cytochrome c; Region: Cytochrom_C; cl11414
742013002266	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
742013002267	putative heme-binding domain, Pirellula/Verrucomicrobium type; Region: CxxCH_TIGR02603
742013002268	Cytochrome c; Region: Cytochrom_C; pfam00034
742013002269	Low affinity iron permease; Region: Iron_permease; pfam04120
742013002270	Domain of unknown function (DUF2383); Region: DUF2383; cl17556
742013002271	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
742013002272	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
742013002273	non-specific DNA binding site [nucleotide binding]; other site
742013002274	salt bridge; other site
742013002275	sequence-specific DNA binding site [nucleotide binding]; other site
742013002276	Predicted transcriptional regulator [General function prediction only]; Region: COG3800
742013002277	Domain of unknown function (DUF955); Region: DUF955; pfam06114
742013002278	Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856
742013002279	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
742013002280	Citrate synthase [Energy production and conversion]; Region: GltA; COG0372
742013002281	Subgroup of Escherichia coli (Ec) 2-methylcitrate synthase (2MCS)_like. 2MCS catalyzes the condensation of propionyl-coenzyme A (PrCoA) and oxalacetate (OAA) to form 2-methylcitrate and coenzyme A (CoA) during propionate metabolism. Citrate synthase (CS)...; Region: Ec2MCS_like_1; cd06117
742013002282	dimer interface [polypeptide binding]; other site
742013002283	active site
742013002284	citrylCoA binding site [chemical binding]; other site
742013002285	oxalacetate/citrate binding site [chemical binding]; other site
742013002286	coenzyme A binding site [chemical binding]; other site
742013002287	catalytic triad [active]
742013002288	2-methylisocitrate dehydratase, Fe/S-dependent; Region: 2met_isocit_dHY; TIGR02333
742013002289	Aconitase A catalytic domain; Region: AcnA_IRP; cd01586
742013002290	substrate binding site [chemical binding]; other site
742013002291	ligand binding site [chemical binding]; other site
742013002292	Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215
742013002293	substrate binding site [chemical binding]; other site
742013002294	Transcriptional regulator [Transcription]; Region: LysR; COG0583
742013002295	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
742013002296	The C-terminal substrate binding domain of LysR-type transcriptional regulator metR, which regulates the expression of methionine biosynthetic genes, contains type 2 periplasmic binding fold; Region: PBP2_MetR; cd08441
742013002297	putative dimerization interface [polypeptide binding]; other site
742013002298	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
742013002299	periplasmic multidrug efflux lipoprotein precursor; Reviewed; Region: PRK09578
742013002300	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
742013002301	HlyD family secretion protein; Region: HlyD_3; pfam13437
742013002302	The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915
742013002303	Protein export membrane protein; Region: SecD_SecF; cl14618
742013002304	copper/silver efflux system outer membrane protein CusC; Provisional; Region: PRK09837
742013002305	GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046
742013002306	putative C-terminal domain interface [polypeptide binding]; other site
742013002307	putative GSH binding site (G-site) [chemical binding]; other site
742013002308	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
742013002309	putative dimer interface [polypeptide binding]; other site
742013002310	C-terminal, alpha helical domain of an unknown subfamily 8 of Glutathione S-transferases; Region: GST_C_8; cd03207
742013002311	dimer interface [polypeptide binding]; other site
742013002312	N-terminal domain interface [polypeptide binding]; other site
742013002313	putative substrate binding pocket (H-site) [chemical binding]; other site
742013002314	DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020
742013002315	catalytic residues [active]
742013002316	Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712
742013002317	FecR protein; Region: FecR; pfam04773
742013002318	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
742013002319	HAMP domain; Region: HAMP; pfam00672
742013002320	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
742013002321	dimer interface [polypeptide binding]; other site
742013002322	putative CheW interface [polypeptide binding]; other site
742013002323	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
742013002324	precorrin-8X methylmutase; Reviewed; Region: cobH; PRK08285
742013002325	Precorrin-8X methylmutase; Region: CbiC; pfam02570
742013002326	Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645
742013002327	active site
742013002328	SAM binding site [chemical binding]; other site
742013002329	homodimer interface [polypeptide binding]; other site
742013002330	Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646
742013002331	active site
742013002332	SAM binding site [chemical binding]; other site
742013002333	homodimer interface [polypeptide binding]; other site
742013002334	Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099
742013002335	Precorrin-6x reductase CbiJ/CobK; Region: CbiJ; pfam02571
742013002336	Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644
742013002337	active site
742013002338	SAM binding site [chemical binding]; other site
742013002339	putative homodimer interface [polypeptide binding]; other site
742013002340	Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242
742013002341	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
742013002342	Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641
742013002343	active site
742013002344	SAM binding site [chemical binding]; other site
742013002345	homodimer interface [polypeptide binding]; other site
742013002346	Precorrin-6A synthase, the cobalamin biosynthesis enzyme CobF; Region: Precorrin-6A-synthase; cd11643
742013002347	active site
742013002348	SAM binding site [chemical binding]; other site
742013002349	homodimer interface [polypeptide binding]; other site
742013002350	N-formylglutamate amidohydrolase; Region: FGase; pfam05013
742013002351	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
742013002352	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
742013002353	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
742013002354	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
742013002355	dimerization interface [polypeptide binding]; other site
742013002356	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
742013002357	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283
742013002358	putative NAD(P) binding site [chemical binding]; other site
742013002359	putative substrate binding site [chemical binding]; other site
742013002360	catalytic Zn binding site [ion binding]; other site
742013002361	structural Zn binding site [ion binding]; other site
742013002362	dimer interface [polypeptide binding]; other site
742013002363	Transcriptional regulator [Transcription]; Region: LysR; COG0583
742013002364	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
742013002365	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474
742013002366	putative effector binding pocket; other site
742013002367	putative dimerization interface [polypeptide binding]; other site
742013002368	ClC chloride channel family. These protein sequences, closely related to the ClC Eric family, are putative halogen ion (Cl-, Br- and I-) transport proteins found in eubacteria. They belong to the ClC superfamily of chloride ion channels, which share a...; Region: EriC_like; cd01034
742013002369	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
742013002370	putative ion selectivity filter; other site
742013002371	putative pore gating glutamate residue; other site
742013002372	putative H+/Cl- coupling transport residue; other site
742013002373	MgtC family; Region: MgtC; pfam02308
742013002374	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
742013002375	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
742013002376	N-terminal plug; other site
742013002377	ligand-binding site [chemical binding]; other site
742013002378	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
742013002379	Helix-turn-helix domain; Region: HTH_18; pfam12833
742013002380	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
742013002381	Transcriptional regulators [Transcription]; Region: FadR; COG2186
742013002382	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
742013002383	DNA-binding site [nucleotide binding]; DNA binding site
742013002384	FCD domain; Region: FCD; pfam07729
742013002385	dihydroxy-acid dehydratase; Validated; Region: PRK06131
742013002386	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181
742013002387	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
742013002388	putative substrate translocation pore; other site
742013002389	Major Facilitator Superfamily; Region: MFS_1; pfam07690
742013002390	Cupin domain; Region: Cupin_2; cl17218
742013002391	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
742013002392	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
742013002393	Cupin; Region: Cupin_6; pfam12852
742013002394	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
742013002395	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
742013002396	Uncharacterized conserved protein [Function unknown]; Region: COG2128
742013002397	Carboxymuconolactone decarboxylase family; Region: CMD; cl00460
742013002398	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
742013002399	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
742013002400	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
742013002401	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
742013002402	Walker A/P-loop; other site
742013002403	ATP binding site [chemical binding]; other site
742013002404	Q-loop/lid; other site
742013002405	ABC transporter signature motif; other site
742013002406	Walker B; other site
742013002407	D-loop; other site
742013002408	H-loop/switch region; other site
742013002409	NMT1-like family; Region: NMT1_2; pfam13379
742013002410	NMT1/THI5 like; Region: NMT1; pfam09084
742013002411	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
742013002412	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
742013002413	dimer interface [polypeptide binding]; other site
742013002414	conserved gate region; other site
742013002415	putative PBP binding loops; other site
742013002416	ABC-ATPase subunit interface; other site
742013002417	DNA-binding transcriptional regulator LysR; Provisional; Region: PRK11013
742013002418	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
742013002419	The C-terminal substrate-domain of LysR-type transcriptional regulators involved in the catabolism of opines and that of related regulators, contains the type 2 periplasmic binding fold; Region: PBP2_LysR_opines_like; cd08415
742013002420	putative dimerization interface [polypeptide binding]; other site
742013002421	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
742013002422	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
742013002423	eyelet of channel; other site
742013002424	trimer interface [polypeptide binding]; other site
742013002425	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
742013002426	Predicted acyl esterases [General function prediction only]; Region: COG2936
742013002427	X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939
742013002428	short chain dehydrogenase; Provisional; Region: PRK06172
742013002429	classical (c) SDRs; Region: SDR_c; cd05233
742013002430	NAD(P) binding site [chemical binding]; other site
742013002431	active site
742013002432	This model contains proteins with the VRR-NUC domain; Region: VRR_NUC; smart00990
742013002433	CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641
742013002434	DEAD_2; Region: DEAD_2; pfam06733
742013002435	Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199
742013002436	Helicase C-terminal domain; Region: Helicase_C_2; pfam13307
742013002437	Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810
742013002438	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
742013002439	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
742013002440	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263
742013002441	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
742013002442	glutathione-regulated potassium-efflux system protein KefB; Provisional; Region: PRK03659
742013002443	TrkA-N domain; Region: TrkA_N; pfam02254
742013002444	ATP-binding cassette domain of an uncharacterized transporter similar in sequence to NatA; Region: ABC_NatA_like; cd03267
742013002445	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
742013002446	Walker A/P-loop; other site
742013002447	ATP binding site [chemical binding]; other site
742013002448	Q-loop/lid; other site
742013002449	ABC transporter signature motif; other site
742013002450	Walker B; other site
742013002451	D-loop; other site
742013002452	H-loop/switch region; other site
742013002453	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587
742013002454	ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496
742013002455	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199
742013002456	homotrimer interaction site [polypeptide binding]; other site
742013002457	putative active site [active]
742013002458	Oxidoreductase-like protein, N-terminal; Region: Oxidored-like; pfam09791
742013002459	Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor...; Region: IPT; cd00102
742013002460	Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor...; Region: IPT; cl15674
742013002461	Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor...; Region: IPT; cl15674
742013002462	Putative Ig domain; Region: He_PIG; pfam05345
742013002463	Microcystin-dependent protein [Function unknown]; Region: MdpB; COG4675
742013002464	Phage Tail Collar Domain; Region: Collar; pfam07484
742013002465	Microcystin-dependent protein [Function unknown]; Region: MdpB; COG4675
742013002466	Phage Tail Collar Domain; Region: Collar; pfam07484
742013002467	Microcystin-dependent protein [Function unknown]; Region: MdpB; COG4675
742013002468	Phage Tail Collar Domain; Region: Collar; pfam07484
742013002469	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
742013002470	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
742013002471	Coenzyme A binding pocket [chemical binding]; other site
742013002472	Transcriptional regulator [Transcription]; Region: LysR; COG0583
742013002473	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
742013002474	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
742013002475	dimerization interface [polypeptide binding]; other site
742013002476	Isopentenyl diphosphate isomerase (BS_ypgA, MTH48 and related proteins) [Coenzyme transport and metabolism]; Region: idi; COG1304
742013002477	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
742013002478	phosphate binding site [ion binding]; other site
742013002479	hypothetical protein; Validated; Region: PRK06201
742013002480	Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480
742013002481	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
742013002482	Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173
742013002483	ligand binding site [chemical binding]; other site
742013002484	NAD binding site [chemical binding]; other site
742013002485	dimerization interface [polypeptide binding]; other site
742013002486	catalytic site [active]
742013002487	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181
742013002488	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
742013002489	P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539
742013002490	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
742013002491	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
742013002492	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
742013002493	catalytic residue [active]
742013002494	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
742013002495	non-specific DNA binding site [nucleotide binding]; other site
742013002496	salt bridge; other site
742013002497	sequence-specific DNA binding site [nucleotide binding]; other site
742013002498	serine O-acetyltransferase; Region: cysE; TIGR01172
742013002499	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
742013002500	trimer interface [polypeptide binding]; other site
742013002501	active site
742013002502	substrate binding site [chemical binding]; other site
742013002503	CoA binding site [chemical binding]; other site
742013002504	Member of the Rhodanese Homology Domain superfamily, subgroup 1. This CD includes the putative rhodanese-related sulfurtransferases of several uncharacterized proteins; Region: RHOD_1; cd01522
742013002505	active site residue [active]
742013002506	manganese transport protein MntH; Reviewed; Region: PRK00701
742013002507	Natural resistance-associated macrophage protein; Region: Nramp; pfam01566
742013002508	Ferritin-like domain; Region: Ferritin_2; pfam13668
742013002509	Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335
742013002510	Fasciclin domain; Region: Fasciclin; pfam02469
742013002511	AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137
742013002512	conserved cys residue [active]
742013002513	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
742013002514	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
742013002515	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
742013002516	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
742013002517	Predicted transcriptional regulators [Transcription]; Region: COG1733
742013002518	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
742013002519	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
742013002520	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
742013002521	NAD(P) binding site [chemical binding]; other site
742013002522	active site
742013002523	4-Oxalocrotonate Tautomerase:  Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235
742013002524	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
742013002525	Predicted metal-dependent enzyme of the double-stranded beta helix superfamily [General function prediction only]; Region: COG5553
742013002526	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
742013002527	active site residue [active]
742013002528	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
742013002529	active site residue [active]
742013002530	Member of the Rhodanese Homology Domain superfamily, repeat 3. This CD includes putative rhodanese-related sulfurtransferases which contain 4 copies of the Rhodanese Homology Domain. This CD aligns the 3rd repeat which does not contain the putative...; Region: 4RHOD_Repeat_3; cd01534
742013002531	active site residue [active]
742013002532	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
742013002533	active site residue [active]
742013002534	Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626
742013002535	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
742013002536	homodimer interface [polypeptide binding]; other site
742013002537	substrate-cofactor binding pocket; other site
742013002538	pyridoxal 5'-phosphate binding site [chemical binding]; other site
742013002539	catalytic residue [active]
742013002540	Predicted metal-dependent enzyme of the double-stranded beta helix superfamily [General function prediction only]; Region: COG5553
742013002541	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
742013002542	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
742013002543	Walker A/P-loop; other site
742013002544	ATP binding site [chemical binding]; other site
742013002545	Q-loop/lid; other site
742013002546	ABC transporter signature motif; other site
742013002547	Walker B; other site
742013002548	D-loop; other site
742013002549	H-loop/switch region; other site
742013002550	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
742013002551	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
742013002552	dimer interface [polypeptide binding]; other site
742013002553	conserved gate region; other site
742013002554	putative PBP binding loops; other site
742013002555	ABC-ATPase subunit interface; other site
742013002556	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
742013002557	dimer interface [polypeptide binding]; other site
742013002558	conserved gate region; other site
742013002559	putative PBP binding loops; other site
742013002560	ABC-ATPase subunit interface; other site
742013002561	aspartate aminotransferase; Provisional; Region: PRK06107
742013002562	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
742013002563	pyridoxal 5'-phosphate binding site [chemical binding]; other site
742013002564	homodimer interface [polypeptide binding]; other site
742013002565	catalytic residue [active]
742013002566	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
742013002567	FAD binding domain; Region: FAD_binding_4; pfam01565
742013002568	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
742013002569	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
742013002570	substrate binding pocket [chemical binding]; other site
742013002571	membrane-bound complex binding site; other site
742013002572	hinge residues; other site
742013002573	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
742013002574	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
742013002575	substrate binding pocket [chemical binding]; other site
742013002576	membrane-bound complex binding site; other site
742013002577	hinge residues; other site
742013002578	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
742013002579	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
742013002580	substrate binding pocket [chemical binding]; other site
742013002581	membrane-bound complex binding site; other site
742013002582	hinge residues; other site
742013002583	Protein of unknown function (DUF1311); Region: DUF1311; cl01530
742013002584	putative major fimbrial protein SthE; Provisional; Region: PRK15292
742013002585	Fimbrial protein; Region: Fimbrial; pfam00419
742013002586	ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747
742013002587	Domain of unknown function (DUF1768); Region: DUF1768; pfam08719
742013002588	Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419
742013002589	RNA:NAD 2'-phosphotransferase [Translation, ribosomal structure and biogenesis]; Region: KptA; COG1859
742013002590	RNA 2'-phosphotransferase; Reviewed; Region: PRK00819
742013002591	NADH kinase; Region: PLN02929
742013002592	SPFH domain / Band 7 family; Region: Band_7; pfam01145
742013002593	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
742013002594	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883
742013002595	nudix motif; other site
742013002596	Uncharacterized conserved protein [General function prediction only]; Region: COG4111
742013002597	Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171
742013002598	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
742013002599	tetramer interface [polypeptide binding]; other site
742013002600	pyridoxal 5'-phosphate binding site [chemical binding]; other site
742013002601	catalytic residue [active]
742013002602	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964
742013002603	YheO-like PAS domain; Region: PAS_6; pfam08348
742013002604	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
742013002605	DNA-binding interface [nucleotide binding]; DNA binding site
742013002606	YeaK is an uncharacterized Echerichia coli protein with a YbaK-like domain of unknown function.  The YbaK-like domain family includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting...; Region: YeaK; cd04336
742013002607	putative deacylase active site [active]
742013002608	CHAD domain; Region: CHAD; pfam05235
742013002609	TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785
742013002610	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
742013002611	N-terminal plug; other site
742013002612	ligand-binding site [chemical binding]; other site
742013002613	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
742013002614	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
742013002615	intersubunit interface [polypeptide binding]; other site
742013002616	FecCD transport family; Region: FecCD; pfam01032
742013002617	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
742013002618	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
742013002619	Walker A/P-loop; other site
742013002620	ATP binding site [chemical binding]; other site
742013002621	Q-loop/lid; other site
742013002622	ABC transporter signature motif; other site
742013002623	Walker B; other site
742013002624	D-loop; other site
742013002625	H-loop/switch region; other site
742013002626	Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141
742013002627	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
742013002628	cobalamin biosynthesis protein CobW; Region: CobW; TIGR02475
742013002629	CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492
742013002630	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683
742013002631	cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK05989
742013002632	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
742013002633	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
742013002634	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
742013002635	Walker A motif; other site
742013002636	ATP binding site [chemical binding]; other site
742013002637	Walker B motif; other site
742013002638	arginine finger; other site
742013002639	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
742013002640	metal ion-dependent adhesion site (MIDAS); other site
742013002641	HAMP domain; Region: HAMP; pfam00672
742013002642	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
742013002643	dimer interface [polypeptide binding]; other site
742013002644	phosphorylation site [posttranslational modification]
742013002645	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
742013002646	ATP binding site [chemical binding]; other site
742013002647	Mg2+ binding site [ion binding]; other site
742013002648	G-X-G motif; other site
742013002649	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
742013002650	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
742013002651	active site
742013002652	phosphorylation site [posttranslational modification]
742013002653	intermolecular recognition site; other site
742013002654	dimerization interface [polypeptide binding]; other site
742013002655	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
742013002656	DNA binding site [nucleotide binding]
742013002657	The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915
742013002658	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
742013002659	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
742013002660	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
742013002661	Walker A/P-loop; other site
742013002662	Walker A/P-loop; other site
742013002663	ATP binding site [chemical binding]; other site
742013002664	ATP binding site [chemical binding]; other site
742013002665	Q-loop/lid; other site
742013002666	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
742013002667	ABC transporter signature motif; other site
742013002668	Walker B; other site
742013002669	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
742013002670	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
742013002671	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
742013002672	ligand binding site [chemical binding]; other site
742013002673	flexible hinge region; other site
742013002674	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
742013002675	putative switch regulator; other site
742013002676	non-specific DNA interactions [nucleotide binding]; other site
742013002677	DNA binding site [nucleotide binding]
742013002678	sequence specific DNA binding site [nucleotide binding]; other site
742013002679	putative cAMP binding site [chemical binding]; other site
742013002680	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
742013002681	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
742013002682	catalytic loop [active]
742013002683	iron binding site [ion binding]; other site
742013002684	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
742013002685	cyclase homology domain; Region: CHD; cd07302
742013002686	nucleotidyl binding site; other site
742013002687	metal binding site [ion binding]; metal-binding site
742013002688	dimer interface [polypeptide binding]; other site
742013002689	Predicted membrane protein [Function unknown]; Region: COG2259
742013002690	Transcriptional regulators [Transcription]; Region: FadR; COG2186
742013002691	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
742013002692	DNA-binding site [nucleotide binding]; DNA binding site
742013002693	FCD domain; Region: FCD; pfam07729
742013002694	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
742013002695	Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008
742013002696	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
742013002697	catalytic residue [active]
742013002698	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
742013002699	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
742013002700	Type I periplasmic binding domain of uncharacterized extracellular ligand-binding proteins; Region: PBP1_STKc_like; cd06326
742013002701	putative ligand binding site [chemical binding]; other site
742013002702	Protein of unknown function (DUF969); Region: DUF969; pfam06149
742013002703	Predicted membrane protein [Function unknown]; Region: COG3817
742013002704	Protein of unknown function (DUF979); Region: DUF979; pfam06166
742013002705	Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I:  Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501
742013002706	putative substrate binding pocket [chemical binding]; other site
742013002707	AC domain interface; other site
742013002708	catalytic triad [active]
742013002709	AB domain interface; other site
742013002710	interchain disulfide; other site
742013002711	LamB/YcsF family of  lactam utilization protein; Region: LamB_YcsF_like; cd10787
742013002712	putative active site [active]
742013002713	Allophanate hydrolase subunit 1; Region: AHS1; pfam02682
742013002714	Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896
742013002715	Allophanate hydrolase subunit 2; Region: AHS2; smart00797
742013002716	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
742013002717	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
742013002718	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
742013002719	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
742013002720	Biotin carboxyl carrier protein [Lipid metabolism]; Region: AccB; COG0511
742013002721	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
742013002722	carboxyltransferase (CT) interaction site; other site
742013002723	biotinylation site [posttranslational modification]; other site
742013002724	NAD pyrophosphatase/5'-nucleotidase NadN; Region: nadN; TIGR01530
742013002725	CD73 ecto-5'-nucleotidase and related proteins, N-terminal metallophosphatase domain; Region: MPP_CD73_N; cd07409
742013002726	active site
742013002727	metal binding site [ion binding]; metal-binding site
742013002728	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
742013002729	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
742013002730	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
742013002731	metal-binding site [ion binding]
742013002732	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
742013002733	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
742013002734	metal-binding site [ion binding]
742013002735	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
742013002736	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
742013002737	motif II; other site
742013002738	riboflavin synthase subunit alpha; Provisional; Region: PRK13020
742013002739	Lumazine binding domain; Region: Lum_binding; pfam00677
742013002740	Lumazine binding domain; Region: Lum_binding; pfam00677
742013002741	Protein of unknown function (DUF342); Region: DUF342; pfam03961
742013002742	Domain of unknown function (DUF2760); Region: DUF2760; pfam10816
742013002743	Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170
742013002744	nucleotide binding site [chemical binding]; other site
742013002745	putative NEF/HSP70 interaction site [polypeptide binding]; other site
742013002746	SBD interface [polypeptide binding]; other site
742013002747	Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170
742013002748	nucleotide binding site [chemical binding]; other site
742013002749	putative NEF/HSP70 interaction site [polypeptide binding]; other site
742013002750	SBD interface [polypeptide binding]; other site
742013002751	DNA-K related protein; Region: DUF3731; pfam12531
742013002752	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
742013002753	Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103
742013002754	tetramerization interface [polypeptide binding]; other site
742013002755	NAD(P) binding site [chemical binding]; other site
742013002756	catalytic residues [active]
742013002757	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
742013002758	Fusaric acid resistance protein family; Region: FUSC; pfam04632
742013002759	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
742013002760	Winged helix DNA-binding domain; Region: HTH_27; pfam13463
742013002761	Conserved hypothetical protein 698; Region: Cons_hypoth698; pfam03601
742013002762	putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837
742013002763	C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420
742013002764	putative dimerization interface [polypeptide binding]; other site
742013002765	CreA protein; Region: CreA; pfam05981
742013002766	cyanophycin synthetase; Provisional; Region: PRK14016
742013002767	ATP-grasp domain; Region: ATP-grasp_4; pfam13535
742013002768	ATP-grasp domain; Region: ATP-grasp_4; cl17255
742013002769	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
742013002770	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
742013002771	cyanophycin synthetase; Provisional; Region: PRK14016
742013002772	ATP-grasp domain; Region: ATP-grasp_4; pfam13535
742013002773	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
742013002774	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
742013002775	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
742013002776	Walker A/P-loop; other site
742013002777	ATP binding site [chemical binding]; other site
742013002778	Q-loop/lid; other site
742013002779	ABC transporter signature motif; other site
742013002780	Walker B; other site
742013002781	D-loop; other site
742013002782	H-loop/switch region; other site
742013002783	Domain of unknown function (DUF1854); Region: DUF1854; pfam08909
742013002784	EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cd00051
742013002785	EF-hand domain pair; Region: EF_hand_5; pfam13499
742013002786	Ca2+ binding site [ion binding]; other site
742013002787	5'-nucleotidase; Region: 5-nucleotidase; pfam06189
742013002788	type II secretion system protein F; Region: GspF; TIGR02120
742013002789	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
742013002790	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
742013002791	GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046
742013002792	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
742013002793	putative C-terminal domain interface [polypeptide binding]; other site
742013002794	putative GSH binding site (G-site) [chemical binding]; other site
742013002795	putative dimer interface [polypeptide binding]; other site
742013002796	C-terminal, alpha helical domain of an unknown subfamily 8 of Glutathione S-transferases; Region: GST_C_8; cd03207
742013002797	dimer interface [polypeptide binding]; other site
742013002798	N-terminal domain interface [polypeptide binding]; other site
742013002799	putative substrate binding pocket (H-site) [chemical binding]; other site
742013002800	Predicted transcriptional regulator [Transcription]; Region: COG2378
742013002801	HTH domain; Region: HTH_11; pfam08279
742013002802	WYL domain; Region: WYL; pfam13280
742013002803	luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558
742013002804	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
742013002805	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347
742013002806	type II secretion system protein E; Region: type_II_gspE; TIGR02533
742013002807	PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129
742013002808	Walker A motif; other site
742013002809	ATP binding site [chemical binding]; other site
742013002810	Walker B motif; other site
742013002811	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
742013002812	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
742013002813	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
742013002814	pilus (MSHA type) biogenesis protein MshL; Region: pilus_MshL; TIGR02519
742013002815	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
742013002816	Type II secretion system (T2SS), protein L; Region: T2SL; pfam05134
742013002817	Type II secretion system (T2SS), protein K; Region: T2SK; pfam03934
742013002818	prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532
742013002819	type II secretion system protein I; Region: gspI; TIGR01707
742013002820	Type II secretion system (T2SS), protein I; Region: T2SI; pfam02501
742013002821	Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165
742013002822	Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334
742013002823	Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cl11399
742013002824	cobalamin synthase; Reviewed; Region: cobS; PRK00235
742013002825	threonine dehydratase; Reviewed; Region: PRK09224
742013002826	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
742013002827	tetramer interface [polypeptide binding]; other site
742013002828	pyridoxal 5'-phosphate binding site [chemical binding]; other site
742013002829	catalytic residue [active]
742013002830	First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906
742013002831	putative Ile/Val binding site [chemical binding]; other site
742013002832	Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907
742013002833	putative Ile/Val binding site [chemical binding]; other site
742013002834	OsmC-like protein; Region: OsmC; cl00767
742013002835	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264
742013002836	dinuclear metal binding motif [ion binding]; other site
742013002837	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
742013002838	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
742013002839	trimer interface [polypeptide binding]; other site
742013002840	eyelet of channel; other site
742013002841	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
742013002842	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
742013002843	trimer interface [polypeptide binding]; other site
742013002844	eyelet of channel; other site
742013002845	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
742013002846	M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666
742013002847	metal binding site [ion binding]; metal-binding site
742013002848	putative dimer interface [polypeptide binding]; other site
742013002849	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
742013002850	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
742013002851	3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK06333
742013002852	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
742013002853	dimer interface [polypeptide binding]; other site
742013002854	active site
742013002855	DNA-binding transcriptional regulator HexR; Provisional; Region: PRK11302
742013002856	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
742013002857	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
742013002858	putative active site [active]
742013002859	transaldolase-like protein; Provisional; Region: PTZ00411
742013002860	Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957
742013002861	active site
742013002862	dimer interface [polypeptide binding]; other site
742013002863	catalytic residue [active]
742013002864	glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179
742013002865	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
742013002866	active site
742013002867	dimer interface [polypeptide binding]; other site
742013002868	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
742013002869	dimer interface [polypeptide binding]; other site
742013002870	active site
742013002871	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
742013002872	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
742013002873	substrate binding pocket [chemical binding]; other site
742013002874	membrane-bound complex binding site; other site
742013002875	hinge residues; other site
742013002876	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
742013002877	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
742013002878	DNA-binding site [nucleotide binding]; DNA binding site
742013002879	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
742013002880	pyridoxal 5'-phosphate binding site [chemical binding]; other site
742013002881	homodimer interface [polypeptide binding]; other site
742013002882	catalytic residue [active]
742013002883	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
742013002884	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_13; cd08517
742013002885	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
742013002886	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
742013002887	dimer interface [polypeptide binding]; other site
742013002888	conserved gate region; other site
742013002889	putative PBP binding loops; other site
742013002890	ABC-ATPase subunit interface; other site
742013002891	nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790
742013002892	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
742013002893	dimer interface [polypeptide binding]; other site
742013002894	conserved gate region; other site
742013002895	putative PBP binding loops; other site
742013002896	ABC-ATPase subunit interface; other site
742013002897	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
742013002898	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
742013002899	Walker A/P-loop; other site
742013002900	ATP binding site [chemical binding]; other site
742013002901	Q-loop/lid; other site
742013002902	ABC transporter signature motif; other site
742013002903	Walker B; other site
742013002904	D-loop; other site
742013002905	H-loop/switch region; other site
742013002906	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
742013002907	dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308
742013002908	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
742013002909	Walker A/P-loop; other site
742013002910	ATP binding site [chemical binding]; other site
742013002911	Q-loop/lid; other site
742013002912	ABC transporter signature motif; other site
742013002913	Walker B; other site
742013002914	D-loop; other site
742013002915	H-loop/switch region; other site
742013002916	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
742013002917	Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574
742013002918	YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300
742013002919	active site
742013002920	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
742013002921	CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492
742013002922	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; cl08458
742013002923	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
742013002924	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
742013002925	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
742013002926	dimerization interface [polypeptide binding]; other site
742013002927	Domain of unknown function (DUF1338); Region: DUF1338; pfam07063
742013002928	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5383
742013002929	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
742013002930	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
742013002931	pyridoxal 5'-phosphate binding site [chemical binding]; other site
742013002932	homodimer interface [polypeptide binding]; other site
742013002933	catalytic residue [active]
742013002934	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
742013002935	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
742013002936	ring oligomerisation interface [polypeptide binding]; other site
742013002937	ATP/Mg binding site [chemical binding]; other site
742013002938	stacking interactions; other site
742013002939	hinge regions; other site
742013002940	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
742013002941	oligomerisation interface [polypeptide binding]; other site
742013002942	mobile loop; other site
742013002943	roof hairpin; other site
742013002944	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
742013002945	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
742013002946	DNA binding residues [nucleotide binding]
742013002947	Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712
742013002948	FecR protein; Region: FecR; pfam04773
742013002949	Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion transport and metabolism]; Region: FhuE; COG4773
742013002950	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
742013002951	N-terminal plug; other site
742013002952	ligand-binding site [chemical binding]; other site
742013002953	macrolide transporter subunit MacA; Provisional; Region: PRK11578
742013002954	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
742013002955	HlyD family secretion protein; Region: HlyD_3; pfam13437
742013002956	macrolide transporter ATP-binding /permease protein; Provisional; Region: PRK10535
742013002957	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
742013002958	Walker A/P-loop; other site
742013002959	ATP binding site [chemical binding]; other site
742013002960	Q-loop/lid; other site
742013002961	ABC transporter signature motif; other site
742013002962	Walker B; other site
742013002963	D-loop; other site
742013002964	H-loop/switch region; other site
742013002965	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
742013002966	FtsX-like permease family; Region: FtsX; pfam02687
742013002967	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
742013002968	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
742013002969	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3558
742013002970	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
742013002971	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
742013002972	catalytic triad [active]
742013002973	Protein of unknown function (DUF779); Region: DUF779; pfam05610
742013002974	Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116
742013002975	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
742013002976	NAD(P) binding site [chemical binding]; other site
742013002977	catalytic residues [active]
742013002978	GAF domain; Region: GAF; pfam01590
742013002979	psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974
742013002980	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
742013002981	Walker A motif; other site
742013002982	ATP binding site [chemical binding]; other site
742013002983	Walker B motif; other site
742013002984	arginine finger; other site
742013002985	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
742013002986	hypothetical protein; Reviewed; Region: PRK09588
742013002987	Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139
742013002988	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
742013002989	Transcriptional regulator [Transcription]; Region: IclR; COG1414
742013002990	Bacterial transcriptional regulator; Region: IclR; pfam01614
742013002991	hypothetical protein; Provisional; Region: PRK07338
742013002992	M20 Peptidase Glutamate carboxypeptidase, a periplasmic enzyme; Region: M20_CPDG2; cd03885
742013002993	metal binding site [ion binding]; metal-binding site
742013002994	dimer interface [polypeptide binding]; other site
742013002995	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
742013002996	Transcriptional regulator [Transcription]; Region: LysR; COG0583
742013002997	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
742013002998	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
742013002999	dimerization interface [polypeptide binding]; other site
742013003000	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_18; cd08357
742013003001	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
742013003002	putative metal binding site [ion binding]; other site
742013003003	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
742013003004	Putative glycerate dehydrogenase and related proteins of the D-specific 2-hydroxy dehydrogenase family; Region: GDH_like_2; cd12164
742013003005	putative ligand binding site [chemical binding]; other site
742013003006	NAD binding site [chemical binding]; other site
742013003007	dimerization interface [polypeptide binding]; other site
742013003008	catalytic site [active]
742013003009	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
742013003010	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
742013003011	The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432
742013003012	dimerization interface [polypeptide binding]; other site
742013003013	substrate binding pocket [chemical binding]; other site
742013003014	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
742013003015	homotrimer interaction site [polypeptide binding]; other site
742013003016	putative active site [active]
742013003017	Transcriptional regulator [Transcription]; Region: LysR; COG0583
742013003018	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
742013003019	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
742013003020	dimerization interface [polypeptide binding]; other site
742013003021	4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase, C-terminal subunit; Region: HpaG-C-term; TIGR02303
742013003022	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
742013003023	N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145
742013003024	Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378
742013003025	Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968
742013003026	N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146
742013003027	Hydantoinase B/oxoprolinase; Region: Hydantoinase_B; pfam02538
742013003028	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
742013003029	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
742013003030	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683
742013003031	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
742013003032	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
742013003033	trimer interface [polypeptide binding]; other site
742013003034	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
742013003035	eyelet of channel; other site
742013003036	quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754
742013003037	Quinone oxidoreductase (QOR); Region: QOR2; cd05286
742013003038	NADP binding site [chemical binding]; other site
742013003039	dimer interface [polypeptide binding]; other site
742013003040	Transcriptional regulator [Transcription]; Region: LysR; COG0583
742013003041	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
742013003042	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
742013003043	putative effector binding pocket; other site
742013003044	dimerization interface [polypeptide binding]; other site
742013003045	EamA-like transporter family; Region: EamA; pfam00892
742013003046	Transcriptional regulator [Transcription]; Region: LysR; COG0583
742013003047	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
742013003048	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
742013003049	putative effector binding pocket; other site
742013003050	dimerization interface [polypeptide binding]; other site
742013003051	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
742013003052	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
742013003053	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
742013003054	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
742013003055	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
742013003056	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
742013003057	catalytic loop [active]
742013003058	iron binding site [ion binding]; other site
742013003059	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
742013003060	Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016
742013003061	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
742013003062	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
742013003063	Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion transport and metabolism]; Region: FhuE; COG4773
742013003064	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
742013003065	N-terminal plug; other site
742013003066	ligand-binding site [chemical binding]; other site
742013003067	ferrichrome/ferrioxamine B periplasmic transporter; Provisional; Region: PRK14048
742013003068	Periplasmic binding protein TroA_f.  These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea.  They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_f; cd01139
742013003069	putative ligand binding residues [chemical binding]; other site
742013003070	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
742013003071	ABC-ATPase subunit  interface; other site
742013003072	dimer interface [polypeptide binding]; other site
742013003073	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
742013003074	putative PBP binding regions; other site
742013003075	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
742013003076	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
742013003077	Walker A/P-loop; other site
742013003078	ATP binding site [chemical binding]; other site
742013003079	Q-loop/lid; other site
742013003080	ABC transporter signature motif; other site
742013003081	Walker B; other site
742013003082	D-loop; other site
742013003083	H-loop/switch region; other site
742013003084	ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988
742013003085	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
742013003086	Walker A/P-loop; other site
742013003087	ATP binding site [chemical binding]; other site
742013003088	Q-loop/lid; other site
742013003089	ABC transporter signature motif; other site
742013003090	Walker B; other site
742013003091	D-loop; other site
742013003092	H-loop/switch region; other site
742013003093	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
742013003094	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
742013003095	Walker A/P-loop; other site
742013003096	ATP binding site [chemical binding]; other site
742013003097	Q-loop/lid; other site
742013003098	ABC transporter signature motif; other site
742013003099	Walker B; other site
742013003100	D-loop; other site
742013003101	H-loop/switch region; other site
742013003102	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
742013003103	Cytochrome c; Region: Cytochrom_C; pfam00034
742013003104	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
742013003105	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
742013003106	Walker A/P-loop; other site
742013003107	ATP binding site [chemical binding]; other site
742013003108	Q-loop/lid; other site
742013003109	ABC transporter signature motif; other site
742013003110	Walker B; other site
742013003111	D-loop; other site
742013003112	H-loop/switch region; other site
742013003113	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
742013003114	ABC-ATPase subunit interface; other site
742013003115	putative PBP binding loops; other site
742013003116	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432
742013003117	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
742013003118	O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873
742013003119	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
742013003120	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
742013003121	catalytic residue [active]
742013003122	Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491
742013003123	non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226
742013003124	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171
742013003125	ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464
742013003126	NLPA lipoprotein; Region: Lipoprotein_9; pfam03180
742013003127	ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258
742013003128	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
742013003129	Walker A/P-loop; other site
742013003130	ATP binding site [chemical binding]; other site
742013003131	Q-loop/lid; other site
742013003132	ABC transporter signature motif; other site
742013003133	Walker B; other site
742013003134	D-loop; other site
742013003135	H-loop/switch region; other site
742013003136	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
742013003137	dimer interface [polypeptide binding]; other site
742013003138	conserved gate region; other site
742013003139	ABC-ATPase subunit interface; other site
742013003140	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
742013003141	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
742013003142	active site
742013003143	transcriptional regulator CysB-like protein; Reviewed; Region: PRK12684
742013003144	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
742013003145	The C-terminal substrate domain of LysR-type transcriptional regulators CysB-like contains type 2 periplasmic binding fold; Region: PBP2_CysB_like; cd08413
742013003146	substrate binding site [chemical binding]; other site
742013003147	dimerization interface [polypeptide binding]; other site
742013003148	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
742013003149	Coenzyme A binding pocket [chemical binding]; other site
742013003150	bifunctional nicotinamide mononucleotide adenylyltransferase/ADP-ribose pyrophosphatase; Provisional; Region: PRK05379
742013003151	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
742013003152	active site
742013003153	nucleotide binding site [chemical binding]; other site
742013003154	HIGH motif; other site
742013003155	KMSKS motif; other site
742013003156	ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051
742013003157	nudix motif; other site
742013003158	NAD synthetase; Provisional; Region: PRK13981
742013003159	Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570
742013003160	multimer interface [polypeptide binding]; other site
742013003161	active site
742013003162	catalytic triad [active]
742013003163	protein interface 1 [polypeptide binding]; other site
742013003164	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
742013003165	homodimer interface [polypeptide binding]; other site
742013003166	NAD binding pocket [chemical binding]; other site
742013003167	ATP binding pocket [chemical binding]; other site
742013003168	Mg binding site [ion binding]; other site
742013003169	active-site loop [active]
742013003170	nicotinate phosphoribosyltransferase; Provisional; Region: PRK05321
742013003171	nicotinate phosphoribosyltransferase; Region: NAPRTase; TIGR01514
742013003172	active site
742013003173	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220
742013003174	catalytic triad [active]
742013003175	conserved cis-peptide bond; other site
742013003176	mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479
742013003177	GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509
742013003178	Substrate binding site; other site
742013003179	Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050
742013003180	ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682
742013003181	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
742013003182	ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134
742013003183	ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220
742013003184	Walker A/P-loop; other site
742013003185	ATP binding site [chemical binding]; other site
742013003186	Q-loop/lid; other site
742013003187	ABC transporter signature motif; other site
742013003188	Walker B; other site
742013003189	D-loop; other site
742013003190	H-loop/switch region; other site
742013003191	C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147
742013003192	putative carbohydrate binding site [chemical binding]; other site
742013003193	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
742013003194	S-adenosylmethionine binding site [chemical binding]; other site
742013003195	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
742013003196	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: GT1_like_1; cd04950
742013003197	putative homodimer interface [polypeptide binding]; other site
742013003198	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
742013003199	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
742013003200	active site
742013003201	UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381
742013003202	Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase  family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786
742013003203	active site
742013003204	homodimer interface [polypeptide binding]; other site
742013003205	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
742013003206	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
742013003207	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
742013003208	This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809
742013003209	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
742013003210	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_4; cd03795
742013003211	putative ADP-binding pocket [chemical binding]; other site
742013003212	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
742013003213	Ligand binding site; other site
742013003214	Putative Catalytic site; other site
742013003215	DXD motif; other site
742013003216	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231
742013003217	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
742013003218	binding surface
742013003219	Tetratricopeptide repeat; Region: TPR_16; pfam13432
742013003220	TPR motif; other site
742013003221	S-adenosylmethionine synthetase; Validated; Region: PRK05250
742013003222	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
742013003223	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
742013003224	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
742013003225	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
742013003226	putative acyl-acceptor binding pocket; other site
742013003227	Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279
742013003228	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
742013003229	putative acyl-acceptor binding pocket; other site
742013003230	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
742013003231	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
742013003232	YihA (EngB) GTPase family; Region: YihA_EngB; cd01876
742013003233	G1 box; other site
742013003234	GTP/Mg2+ binding site [chemical binding]; other site
742013003235	Switch I region; other site
742013003236	G2 box; other site
742013003237	G3 box; other site
742013003238	Switch II region; other site
742013003239	G4 box; other site
742013003240	G5 box; other site
742013003241	glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722
742013003242	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
742013003243	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
742013003244	glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179
742013003245	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
742013003246	active site
742013003247	dimer interface [polypeptide binding]; other site
742013003248	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
742013003249	dimer interface [polypeptide binding]; other site
742013003250	active site
742013003251	SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450
742013003252	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
742013003253	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
742013003254	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
742013003255	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
742013003256	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
742013003257	dimer interface [polypeptide binding]; other site
742013003258	conserved gate region; other site
742013003259	putative PBP binding loops; other site
742013003260	ABC-ATPase subunit interface; other site
742013003261	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
742013003262	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
742013003263	dimer interface [polypeptide binding]; other site
742013003264	conserved gate region; other site
742013003265	putative PBP binding loops; other site
742013003266	ABC-ATPase subunit interface; other site
742013003267	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
742013003268	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
742013003269	Walker A/P-loop; other site
742013003270	ATP binding site [chemical binding]; other site
742013003271	Q-loop/lid; other site
742013003272	ABC transporter signature motif; other site
742013003273	Walker B; other site
742013003274	D-loop; other site
742013003275	H-loop/switch region; other site
742013003276	TOBE domain; Region: TOBE_2; pfam08402
742013003277	Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246
742013003278	Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232
742013003279	Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125
742013003280	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
742013003281	Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167
742013003282	putative substrate binding site [chemical binding]; other site
742013003283	putative ATP binding site [chemical binding]; other site
742013003284	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
742013003285	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
742013003286	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
742013003287	Cytochrome c553 [Energy production and conversion]; Region: COG2863
742013003288	Cytochrome c; Region: Cytochrom_C; cl11414
742013003289	ResB-like family; Region: ResB; pfam05140
742013003290	ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125
742013003291	ResB-like family; Region: ResB; pfam05140
742013003292	ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125
742013003293	cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144
742013003294	TMAO/DMSO reductase; Reviewed; Region: PRK05363
742013003295	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
742013003296	Moco binding site; other site
742013003297	metal coordination site [ion binding]; other site
742013003298	putative sulfite oxidase subunit YedZ; Reviewed; Region: PRK05419
742013003299	Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426
742013003300	Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753
742013003301	Frataxin-like domain; Region: Frataxin_Cyay; pfam01491
742013003302	putative iron binding site [ion binding]; other site
742013003303	penicillin-binding protein 1a; Provisional; Region: mrcA; PRK11636
742013003304	Transglycosylase; Region: Transgly; pfam00912
742013003305	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
742013003306	Competence protein A; Region: Competence_A; pfam11104
742013003307	Tfp pilus assembly protein PilN [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilN; COG3166
742013003308	Fimbrial assembly protein (PilN); Region: PilN; pfam05137
742013003309	Pilus assembly protein, PilO; Region: PilO; pfam04350
742013003310	Tfp pilus assembly protein PilP [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilP; COG3168
742013003311	Pilus assembly protein, PilP; Region: PilP; pfam04351
742013003312	AMIN domain; Region: AMIN; pfam11741
742013003313	type IV pilus secretin (or competence protein) PilQ; Region: IV_pilus_PilQ; TIGR02515
742013003314	Secretin and TonB N terminus short domain; Region: STN; pfam07660
742013003315	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
742013003316	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
742013003317	shikimate kinase; Reviewed; Region: aroK; PRK00131
742013003318	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
742013003319	ADP binding site [chemical binding]; other site
742013003320	magnesium binding site [ion binding]; other site
742013003321	putative shikimate binding site; other site
742013003322	Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195
742013003323	active site
742013003324	dimer interface [polypeptide binding]; other site
742013003325	metal binding site [ion binding]; metal-binding site
742013003326	deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01286
742013003327	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
742013003328	Zn2+ binding site [ion binding]; other site
742013003329	Mg2+ binding site [ion binding]; other site
742013003330	Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286
742013003331	Protein of unknown function (DUF1415); Region: DUF1415; pfam07209
742013003332	Methyltransferase domain; Region: Methyltransf_32; pfam13679
742013003333	Methyltransferase domain; Region: Methyltransf_31; pfam13847
742013003334	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
742013003335	Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016
742013003336	Alkaline phosphatase homologues; Region: alkPPc; smart00098
742013003337	active site
742013003338	dimer interface [polypeptide binding]; other site
742013003339	Alkaline phosphatase homologues; Region: alkPPc; smart00098
742013003340	Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016
742013003341	active site
742013003342	dimer interface [polypeptide binding]; other site
742013003343	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
742013003344	classical (c) SDRs; Region: SDR_c; cd05233
742013003345	short chain dehydrogenase; Provisional; Region: PRK07577
742013003346	NAD(P) binding site [chemical binding]; other site
742013003347	active site
742013003348	beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050
742013003349	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
742013003350	dimer interface [polypeptide binding]; other site
742013003351	active site
742013003352	3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428
742013003353	3-oxoacid CoA-transferase, A subunit; Region: pcaI_scoA_fam; TIGR02429
742013003354	beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431
742013003355	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
742013003356	Bacterial transcriptional regulator; Region: IclR; pfam01614
742013003357	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG1943
742013003358	glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750
742013003359	Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713
742013003360	active site
742013003361	dimer interface [polypeptide binding]; other site
742013003362	Glutamate synthase central domain; Region: Glu_syn_central; pfam04898
742013003363	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
742013003364	active site
742013003365	FMN binding site [chemical binding]; other site
742013003366	substrate binding site [chemical binding]; other site
742013003367	3Fe-4S cluster binding site [ion binding]; other site
742013003368	gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982
742013003369	domain interface; other site
742013003370	glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810
742013003371	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
742013003372	Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805
742013003373	sec-independent translocase; Provisional; Region: tatB; PRK01919
742013003374	twin arginine translocase protein A; Provisional; Region: tatA; PRK02958
742013003375	twin arginine translocase protein A; Provisional; Region: tatA; PRK00442
742013003376	Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276
742013003377	nucleotide binding site/active site [active]
742013003378	HIT family signature motif; other site
742013003379	catalytic residue [active]
742013003380	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
742013003381	Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209
742013003382	active site
742013003383	nucleophile elbow; other site
742013003384	Predicted membrane protein [Function unknown]; Region: COG3671
742013003385	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534
742013003386	metal binding site [ion binding]; metal-binding site
742013003387	phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051
742013003388	The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731
742013003389	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
742013003390	substrate binding site [chemical binding]; other site
742013003391	glutamase interaction surface [polypeptide binding]; other site
742013003392	UDP-glucose 4-epimerase; Region: PLN02240
742013003393	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
742013003394	NAD binding site [chemical binding]; other site
742013003395	homodimer interface [polypeptide binding]; other site
742013003396	active site
742013003397	substrate binding site [chemical binding]; other site
742013003398	TM1410 hypothetical-related protein; Region: DUF297; pfam03537
742013003399	C-terminal Putative NodB-like catalytic domain of PelA-like uncharacterized hypothetical proteins found in bacteria; Region: CE4_PelA_like_C; cd10922
742013003400	putative active site [active]
742013003401	Tetratricopeptide repeat; Region: TPR_15; pfam13429
742013003402	Domain of unknown function (DUF4118); Region: DUF4118; pfam13493
742013003403	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_3; cd03813
742013003404	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
742013003405	Predicted membrane protein [Function unknown]; Region: COG4267
742013003406	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
742013003407	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
742013003408	substrate binding pocket [chemical binding]; other site
742013003409	membrane-bound complex binding site; other site
742013003410	hinge residues; other site
742013003411	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
742013003412	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
742013003413	dimer interface [polypeptide binding]; other site
742013003414	conserved gate region; other site
742013003415	putative PBP binding loops; other site
742013003416	ABC-ATPase subunit interface; other site
742013003417	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
742013003418	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
742013003419	Walker A/P-loop; other site
742013003420	ATP binding site [chemical binding]; other site
742013003421	Q-loop/lid; other site
742013003422	ABC transporter signature motif; other site
742013003423	Walker B; other site
742013003424	D-loop; other site
742013003425	H-loop/switch region; other site
742013003426	ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127
742013003427	ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261
742013003428	Walker A/P-loop; other site
742013003429	ATP binding site [chemical binding]; other site
742013003430	Q-loop/lid; other site
742013003431	ABC transporter signature motif; other site
742013003432	Walker B; other site
742013003433	D-loop; other site
742013003434	H-loop/switch region; other site
742013003435	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
742013003436	Permease; Region: Permease; pfam02405
742013003437	ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463
742013003438	mce related protein; Region: MCE; pfam02470
742013003439	VacJ like lipoprotein; Region: VacJ; cl01073
742013003440	Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; pfam05494
742013003441	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
742013003442	anti sigma factor interaction site; other site
742013003443	regulatory phosphorylation site [posttranslational modification]; other site
742013003444	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
742013003445	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
742013003446	Walker A/P-loop; other site
742013003447	ATP binding site [chemical binding]; other site
742013003448	Q-loop/lid; other site
742013003449	ABC transporter signature motif; other site
742013003450	Walker B; other site
742013003451	D-loop; other site
742013003452	H-loop/switch region; other site
742013003453	ABC-2 type transporter; Region: ABC2_membrane; cl17235
742013003454	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
742013003455	Predicted transcriptional regulator, BolA superfamily [Transcription]; Region: COG5007
742013003456	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
742013003457	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
742013003458	hinge; other site
742013003459	active site
742013003460	ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040
742013003461	ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686
742013003462	Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572
742013003463	Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141
742013003464	NAD binding site [chemical binding]; other site
742013003465	dimerization interface [polypeptide binding]; other site
742013003466	product binding site; other site
742013003467	substrate binding site [chemical binding]; other site
742013003468	zinc binding site [ion binding]; other site
742013003469	catalytic residues [active]
742013003470	histidinol-phosphate aminotransferase; Provisional; Region: PRK04870
742013003471	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
742013003472	pyridoxal 5'-phosphate binding site [chemical binding]; other site
742013003473	homodimer interface [polypeptide binding]; other site
742013003474	catalytic residue [active]
742013003475	Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914
742013003476	putative active site pocket [active]
742013003477	4-fold oligomerization interface [polypeptide binding]; other site
742013003478	metal binding residues [ion binding]; metal-binding site
742013003479	3-fold/trimer interface [polypeptide binding]; other site
742013003480	imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146
742013003481	Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748
742013003482	putative active site [active]
742013003483	oxyanion strand; other site
742013003484	catalytic triad [active]
742013003485	HisA.  Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732
742013003486	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
742013003487	catalytic residues [active]
742013003488	Spherulation-specific family 4; Region: Spherulin4; pfam12138
742013003489	D-hexose-6-phosphate epimerase-like; Region: D-hex-6-P-epi_like; cd09020
742013003490	active site
742013003491	phosphate binding residues; other site
742013003492	catalytic residues [active]
742013003493	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
742013003494	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
742013003495	protein binding site [polypeptide binding]; other site
742013003496	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
742013003497	metabolite-proton symporter; Region: 2A0106; TIGR00883
742013003498	putative substrate translocation pore; other site
742013003499	Uncharacterized conserved protein [Function unknown]; Region: COG0327
742013003500	NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371
742013003501	4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743
742013003502	4-hydroxythreonine-4-phosphate dehydrogenase; Region: pdxA; TIGR00557
742013003503	large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13952
742013003504	large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567
742013003505	Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723
742013003506	Iron-sulfur protein (ISP) component of the bc(1) complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The bc(1) complex is a multisubunit enzyme found in many different organisms including...; Region: Rieske_cytochrome_bc1; cd03470
742013003507	[2Fe-2S] cluster binding site [ion binding]; other site
742013003508	Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290
742013003509	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284
742013003510	Qi binding site; other site
742013003511	intrachain domain interface; other site
742013003512	interchain domain interface [polypeptide binding]; other site
742013003513	heme bH binding site [chemical binding]; other site
742013003514	heme bL binding site [chemical binding]; other site
742013003515	Qo binding site; other site
742013003516	interchain domain interface [polypeptide binding]; other site
742013003517	intrachain domain interface; other site
742013003518	Qi binding site; other site
742013003519	Cytochrome b(C-terminal)/b6/petD; Region: Cytochrom_B_C; pfam00032
742013003520	Qo binding site; other site
742013003521	Cytochrome C1 family; Region: Cytochrom_C1; pfam02167
742013003522	stringent starvation protein A; Provisional; Region: sspA; PRK09481
742013003523	GST_N family, Stringent starvation protein A (SspA) subfamily; SspA is a RNA polymerase (RNAP)-associated protein required for the lytic development of phage P1 and for stationary phase-induced acid tolerance of E. coli. It is implicated in survival...; Region: GST_N_SspA; cd03059
742013003524	C-terminal domain interface [polypeptide binding]; other site
742013003525	putative GSH binding site (G-site) [chemical binding]; other site
742013003526	dimer interface [polypeptide binding]; other site
742013003527	C-terminal, alpha helical domain of Stringent starvation protein A; Region: GST_C_SspA; cd03186
742013003528	dimer interface [polypeptide binding]; other site
742013003529	N-terminal domain interface [polypeptide binding]; other site
742013003530	ClpXP protease specificity-enhancing factor; Provisional; Region: PRK11798
742013003531	preprotein translocase subunit SecA; Reviewed; Region: PRK12904
742013003532	SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958
742013003533	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351
742013003534	nucleotide binding region [chemical binding]; other site
742013003535	ATP-binding site [chemical binding]; other site
742013003536	SEC-C motif; Region: SEC-C; pfam02810
742013003537	Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152
742013003538	heterotetramer interface [polypeptide binding]; other site
742013003539	active site pocket [active]
742013003540	cleavage site
742013003541	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG2607
742013003542	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
742013003543	AAA domain; Region: AAA_14; pfam13173
742013003544	Walker A motif; other site
742013003545	ATP binding site [chemical binding]; other site
742013003546	The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425
742013003547	active site
742013003548	8-oxo-dGMP binding site [chemical binding]; other site
742013003549	nudix motif; other site
742013003550	metal binding site [ion binding]; metal-binding site
742013003551	Domain of unknown function (DUF329); Region: DUF329; pfam03884
742013003552	hypothetical protein; Provisional; Region: PRK05287
742013003553	Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237
742013003554	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
742013003555	CoA-binding site [chemical binding]; other site
742013003556	ATP-binding [chemical binding]; other site
742013003557	Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989
742013003558	Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750
742013003559	Type IV leader peptidase family; Region: Peptidase_A24; pfam01478
742013003560	Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459
742013003561	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
742013003562	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
742013003563	type IV-A pilus assembly ATPase PilB; Region: type_IV_pilB; TIGR02538
742013003564	Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157
742013003565	PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129
742013003566	Walker A motif; other site
742013003567	ATP binding site [chemical binding]; other site
742013003568	Walker B motif; other site
742013003569	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
742013003570	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
742013003571	substrate binding pocket [chemical binding]; other site
742013003572	chain length determination region; other site
742013003573	substrate-Mg2+ binding site; other site
742013003574	catalytic residues [active]
742013003575	aspartate-rich region 1; other site
742013003576	active site lid residues [active]
742013003577	aspartate-rich region 2; other site
742013003578	50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278
742013003579	50S ribosomal protein L21; Validated; Region: rplU; PRK05573
742013003580	50S ribosomal protein L27; Validated; Region: rpmA; PRK05435
742013003581	GTPase CgtA; Reviewed; Region: obgE; PRK12299
742013003582	GTP1/OBG; Region: GTP1_OBG; pfam01018
742013003583	Obg GTPase; Region: Obg; cd01898
742013003584	G1 box; other site
742013003585	GTP/Mg2+ binding site [chemical binding]; other site
742013003586	Switch I region; other site
742013003587	G2 box; other site
742013003588	G3 box; other site
742013003589	Switch II region; other site
742013003590	G4 box; other site
742013003591	G5 box; other site
742013003592	gamma-glutamyl kinase; Provisional; Region: PRK05429
742013003593	AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242
742013003594	nucleotide binding site [chemical binding]; other site
742013003595	homotetrameric interface [polypeptide binding]; other site
742013003596	putative phosphate binding site [ion binding]; other site
742013003597	putative allosteric binding site; other site
742013003598	PUA domain; Region: PUA; pfam01472
742013003599	Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671
742013003600	putative active site [active]
742013003601	Ap4A binding site [chemical binding]; other site
742013003602	nudix motif; other site
742013003603	putative metal binding site [ion binding]; other site
742013003604	prolyl-tRNA synthetase; Provisional; Region: PRK09194
742013003605	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779
742013003606	dimer interface [polypeptide binding]; other site
742013003607	motif 1; other site
742013003608	active site
742013003609	motif 2; other site
742013003610	INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334
742013003611	putative deacylase active site [active]
742013003612	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
742013003613	active site
742013003614	motif 3; other site
742013003615	ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861
742013003616	anticodon binding site; other site
742013003617	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
742013003618	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
742013003619	N-acetyl-D-glucosamine binding site [chemical binding]; other site
742013003620	catalytic residue [active]
742013003621	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
742013003622	Domain of unknown function DUF21; Region: DUF21; pfam01595
742013003623	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
742013003624	Transporter associated domain; Region: CorC_HlyC; smart01091
742013003625	Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028
742013003626	putative GSH binding site [chemical binding]; other site
742013003627	catalytic residues [active]
742013003628	N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328
742013003629	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
742013003630	S-adenosylmethionine binding site [chemical binding]; other site
742013003631	peptide chain release factor 1; Validated; Region: prfA; PRK00591
742013003632	This domain is found in peptide chain release factors; Region: PCRF; smart00937
742013003633	RF-1 domain; Region: RF-1; pfam00472
742013003634	glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045
742013003635	NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213
742013003636	tRNA; other site
742013003637	putative tRNA binding site [nucleotide binding]; other site
742013003638	putative NADP binding site [chemical binding]; other site
742013003639	Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745
742013003640	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
742013003641	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
742013003642	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
742013003643	dimerization interface [polypeptide binding]; other site
742013003644	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181
742013003645	N-formylglutamate amidohydrolase; Region: FGase; pfam05013
742013003646	Protein of unknown function (DUF3772); Region: DUF3772; pfam12607
742013003647	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: COG3264
742013003648	Mechanosensitive ion channel; Region: MS_channel; pfam00924
742013003649	cytoplasmic glycerophosphodiester phosphodiesterase; Provisional; Region: ugpQ; PRK09454
742013003650	Glycerophosphodiester phosphodiesterase domain in Escherichia coli cytosolic glycerophosphodiester phosphodiesterase UgpQ and similar proteins; Region: GDPD_EcUgpQ_like; cd08562
742013003651	putative active site [active]
742013003652	catalytic site [active]
742013003653	putative metal binding site [ion binding]; other site
742013003654	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
742013003655	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
742013003656	Walker A/P-loop; other site
742013003657	ATP binding site [chemical binding]; other site
742013003658	Q-loop/lid; other site
742013003659	ABC transporter signature motif; other site
742013003660	Walker B; other site
742013003661	D-loop; other site
742013003662	H-loop/switch region; other site
742013003663	TOBE domain; Region: TOBE_2; pfam08402
742013003664	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
742013003665	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
742013003666	dimer interface [polypeptide binding]; other site
742013003667	conserved gate region; other site
742013003668	putative PBP binding loops; other site
742013003669	ABC-ATPase subunit interface; other site
742013003670	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
742013003671	dimer interface [polypeptide binding]; other site
742013003672	conserved gate region; other site
742013003673	putative PBP binding loops; other site
742013003674	ABC-ATPase subunit interface; other site
742013003675	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
742013003676	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
742013003677	Protein of unknown function (DUF3683); Region: DUF3683; pfam12447
742013003678	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
742013003679	FAD binding domain; Region: FAD_binding_4; pfam01565
742013003680	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
742013003681	4Fe-4S dicluster domain; Region: Fer4_8; pfam13183
742013003682	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
742013003683	Cysteine-rich domain; Region: CCG; pfam02754
742013003684	Domain of unknown function (DUF3400); Region: DUF3400; pfam11880
742013003685	Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537
742013003686	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3536
742013003687	Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226
742013003688	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
742013003689	S-adenosylmethionine binding site [chemical binding]; other site
742013003690	Tim44 is an essential component of the machinery that mediates the translocation of nuclear-encoded proteins across the mitochondrial inner membrane; Region: Tim44; smart00978
742013003691	SCP-2 sterol transfer family; Region: SCP2; cl01225
742013003692	putative ubiquinone biosynthesis protein UbiB; Reviewed; Region: ubiB; PRK04750
742013003693	2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982
742013003694	Na(+)- and Cl(-)-dependent choline cotransporter CHT and related proteins; solute-binding domain; Region: SLC5sbd_CHT; cd11474
742013003695	Na binding site [ion binding]; other site
742013003696	putative glycosylation site [posttranslational modification]; other site
742013003697	putative glycosylation site [posttranslational modification]; other site
742013003698	Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993
742013003699	Uncharacterized conserved protein [Function unknown]; Region: COG2928
742013003700	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
742013003701	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
742013003702	dimer interface [polypeptide binding]; other site
742013003703	anticodon binding site; other site
742013003704	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
742013003705	homodimer interface [polypeptide binding]; other site
742013003706	motif 1; other site
742013003707	active site
742013003708	motif 2; other site
742013003709	GAD domain; Region: GAD; pfam02938
742013003710	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
742013003711	motif 3; other site
742013003712	Curli production assembly/transport component CsgG; Region: CsgG; cl17434
742013003713	dihydroneopterin triphosphate pyrophosphatase; Provisional; Region: nudB; PRK09438
742013003714	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
742013003715	putative catalytic site [active]
742013003716	putative metal binding site [ion binding]; other site
742013003717	putative phosphate binding site [ion binding]; other site
742013003718	Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1),  6-pyrovoyl...; Region: TFold; cl00263
742013003719	active site
742013003720	phosphonate utilization associated putative membrane protein; Region: phn_DUF6; TIGR03340
742013003721	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
742013003722	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
742013003723	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
742013003724	Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625
742013003725	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
742013003726	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
742013003727	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
742013003728	amidase; Provisional; Region: PRK07042
742013003729	Amidase; Region: Amidase; cl11426
742013003730	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
742013003731	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_6; cd08494
742013003732	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
742013003733	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
742013003734	Walker A/P-loop; other site
742013003735	ATP binding site [chemical binding]; other site
742013003736	Q-loop/lid; other site
742013003737	ABC transporter signature motif; other site
742013003738	Walker B; other site
742013003739	D-loop; other site
742013003740	H-loop/switch region; other site
742013003741	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
742013003742	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
742013003743	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
742013003744	Walker A/P-loop; other site
742013003745	ATP binding site [chemical binding]; other site
742013003746	Q-loop/lid; other site
742013003747	ABC transporter signature motif; other site
742013003748	Walker B; other site
742013003749	D-loop; other site
742013003750	H-loop/switch region; other site
742013003751	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352
742013003752	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
742013003753	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
742013003754	dimer interface [polypeptide binding]; other site
742013003755	conserved gate region; other site
742013003756	putative PBP binding loops; other site
742013003757	ABC-ATPase subunit interface; other site
742013003758	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
742013003759	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
742013003760	dimer interface [polypeptide binding]; other site
742013003761	conserved gate region; other site
742013003762	putative PBP binding loops; other site
742013003763	ABC-ATPase subunit interface; other site
742013003764	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
742013003765	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
742013003766	putative active site [active]
742013003767	catalytic residue [active]
742013003768	50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618
742013003769	Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495
742013003770	5S rRNA interface [nucleotide binding]; other site
742013003771	CTC domain interface [polypeptide binding]; other site
742013003772	L16 interface [polypeptide binding]; other site
742013003773	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259
742013003774	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
742013003775	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
742013003776	active site
742013003777	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00343
742013003778	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
742013003779	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
742013003780	Outer membrane lipoprotein LolB; Region: LolB; pfam03550
742013003781	TPR repeat; Region: TPR_11; pfam13414
742013003782	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
742013003783	binding surface
742013003784	TPR motif; other site
742013003785	formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103
742013003786	N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966
742013003787	DNA binding site [nucleotide binding]
742013003788	catalytic residue [active]
742013003789	H2TH interface [polypeptide binding]; other site
742013003790	putative catalytic residues [active]
742013003791	turnover-facilitating residue; other site
742013003792	intercalation triad [nucleotide binding]; other site
742013003793	8OG recognition residue [nucleotide binding]; other site
742013003794	putative reading head residues; other site
742013003795	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
742013003796	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
742013003797	Dynamin family; Region: Dynamin_N; pfam00350
742013003798	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
742013003799	G1 box; other site
742013003800	GTP/Mg2+ binding site [chemical binding]; other site
742013003801	G2 box; other site
742013003802	Switch I region; other site
742013003803	G3 box; other site
742013003804	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
742013003805	G3 box; other site
742013003806	Switch II region; other site
742013003807	GTP/Mg2+ binding site [chemical binding]; other site
742013003808	G4 box; other site
742013003809	G5 box; other site
742013003810	A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194
742013003811	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
742013003812	minor groove reading motif; other site
742013003813	helix-hairpin-helix signature motif; other site
742013003814	substrate binding pocket [chemical binding]; other site
742013003815	active site
742013003816	iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525
742013003817	DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread  A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431
742013003818	DNA binding and oxoG recognition site [nucleotide binding]
742013003819	Inner membrane protein CreD; Region: CreD; pfam06123
742013003820	sensory histidine kinase CreC; Provisional; Region: PRK11100
742013003821	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
742013003822	dimer interface [polypeptide binding]; other site
742013003823	phosphorylation site [posttranslational modification]
742013003824	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
742013003825	ATP binding site [chemical binding]; other site
742013003826	G-X-G motif; other site
742013003827	DNA-binding response regulator CreB; Provisional; Region: PRK11083
742013003828	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
742013003829	active site
742013003830	phosphorylation site [posttranslational modification]
742013003831	intermolecular recognition site; other site
742013003832	dimerization interface [polypeptide binding]; other site
742013003833	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
742013003834	DNA binding site [nucleotide binding]
742013003835	glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416
742013003836	Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703
742013003837	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497
742013003838	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
742013003839	Walker A/P-loop; other site
742013003840	ATP binding site [chemical binding]; other site
742013003841	Q-loop/lid; other site
742013003842	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
742013003843	ABC transporter signature motif; other site
742013003844	Walker B; other site
742013003845	D-loop; other site
742013003846	H-loop/switch region; other site
742013003847	NAD(+)/NADH kinase family protein; Provisional; Region: ppnK; PRK02155
742013003848	inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02231
742013003849	heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082
742013003850	Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444
742013003851	CHASE2 domain; Region: CHASE2; pfam05226
742013003852	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
742013003853	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
742013003854	ATP binding site [chemical binding]; other site
742013003855	Mg2+ binding site [ion binding]; other site
742013003856	G-X-G motif; other site
742013003857	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4254
742013003858	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
742013003859	FecR protein; Region: FecR; pfam04773
742013003860	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
742013003861	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
742013003862	active site
742013003863	phosphorylation site [posttranslational modification]
742013003864	intermolecular recognition site; other site
742013003865	dimerization interface [polypeptide binding]; other site
742013003866	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
742013003867	DNA binding site [nucleotide binding]
742013003868	tryptophanyl-tRNA synthetase; Reviewed; Region: PRK12284
742013003869	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
742013003870	active site
742013003871	HIGH motif; other site
742013003872	dimer interface [polypeptide binding]; other site
742013003873	KMSKS motif; other site
742013003874	Domain of unknown function (DUF1508); Region: DUF1508; cl01356
742013003875	Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158
742013003876	Peptidase family M50; Region: Peptidase_M50; pfam02163
742013003877	active site
742013003878	putative substrate binding region [chemical binding]; other site
742013003879	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
742013003880	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
742013003881	dimer interface [polypeptide binding]; other site
742013003882	putative CheW interface [polypeptide binding]; other site
742013003883	Telomere recombination; Region: Sua5_yciO_yrdC; cl00305
742013003884	Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613
742013003885	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438
742013003886	active site
742013003887	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438
742013003888	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
742013003889	dimerization interface [polypeptide binding]; other site
742013003890	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
742013003891	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
742013003892	dimer interface [polypeptide binding]; other site
742013003893	putative CheW interface [polypeptide binding]; other site
742013003894	Putative bacterial lipoprotein (DUF799); Region: DUF799; cl01813
742013003895	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4259
742013003896	Curli production assembly/transport component CsgG; Region: CsgG; pfam03783
742013003897	ssDNA exonuclease RecJ; Provisional; Region: PRK11070
742013003898	DHH family; Region: DHH; pfam01368
742013003899	DHHA1 domain; Region: DHHA1; pfam02272
742013003900	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4255
742013003901	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
742013003902	Sulfatase; Region: Sulfatase; pfam00884
742013003903	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
742013003904	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
742013003905	MarR family; Region: MarR; pfam01047
742013003906	lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212
742013003907	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
742013003908	FtsX-like permease family; Region: FtsX; pfam02687
742013003909	lipoprotein releasing system, ATP-binding protein; Region: LolD_lipo_ex; TIGR02211
742013003910	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
742013003911	Walker A/P-loop; other site
742013003912	ATP binding site [chemical binding]; other site
742013003913	Q-loop/lid; other site
742013003914	ABC transporter signature motif; other site
742013003915	Walker B; other site
742013003916	D-loop; other site
742013003917	H-loop/switch region; other site
742013003918	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
742013003919	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
742013003920	putative active site [active]
742013003921	heme pocket [chemical binding]; other site
742013003922	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
742013003923	putative active site [active]
742013003924	heme pocket [chemical binding]; other site
742013003925	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
742013003926	dimer interface [polypeptide binding]; other site
742013003927	Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015
742013003928	putative CheW interface [polypeptide binding]; other site
742013003929	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
742013003930	active site
742013003931	MUG-like Uracil-DNA glycosylase enzyme family; Region: UDG_MUG_like; cd10032
742013003932	putative active site [active]
742013003933	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
742013003934	Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157
742013003935	Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804
742013003936	PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129
742013003937	Walker A motif; other site
742013003938	ATP binding site [chemical binding]; other site
742013003939	Walker B motif; other site
742013003940	Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331
742013003941	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3333
742013003942	Protein of unknown function (DUF3422); Region: DUF3422; pfam11902
742013003943	short chain dehydrogenase; Provisional; Region: PRK08339
742013003944	putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344
742013003945	putative NAD(P) binding site [chemical binding]; other site
742013003946	putative active site [active]
742013003947	PAS domain; Region: PAS; smart00091
742013003948	PAS fold; Region: PAS_7; pfam12860
742013003949	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
742013003950	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
742013003951	metal binding site [ion binding]; metal-binding site
742013003952	active site
742013003953	I-site; other site
742013003954	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
742013003955	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
742013003956	EamA-like transporter family; Region: EamA; pfam00892
742013003957	EamA-like transporter family; Region: EamA; pfam00892
742013003958	quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754
742013003959	Quinone oxidoreductase (QOR); Region: QOR2; cd05286
742013003960	NADP binding site [chemical binding]; other site
742013003961	dimer interface [polypeptide binding]; other site
742013003962	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
742013003963	nudix motif; other site
742013003964	Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283
742013003965	Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
742013003966	Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
742013003967	PhoU domain; Region: PhoU; pfam01895
742013003968	lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376
742013003969	isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743
742013003970	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
742013003971	active site
742013003972	HIGH motif; other site
742013003973	nucleotide binding site [chemical binding]; other site
742013003974	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
742013003975	active site
742013003976	KMSKS motif; other site
742013003977	Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960
742013003978	tRNA binding surface [nucleotide binding]; other site
742013003979	anticodon binding site; other site
742013003980	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
742013003981	bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627
742013003982	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
742013003983	active site
742013003984	Riboflavin kinase; Region: Flavokinase; smart00904
742013003985	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
742013003986	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
742013003987	active site
742013003988	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
742013003989	binding surface
742013003990	Predicted methyltransferase (contains TPR repeat) [General function prediction only]; Region: COG4976
742013003991	TPR motif; other site
742013003992	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
742013003993	TPR repeat; Region: TPR_11; pfam13414
742013003994	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
742013003995	TPR motif; other site
742013003996	binding surface
742013003997	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
742013003998	binding surface
742013003999	TPR motif; other site
742013004000	Predicted methyltransferase (contains TPR repeat) [General function prediction only]; Region: COG4976
742013004001	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
742013004002	7TMR-DISM extracellular 2; Region: 7TMR-DISMED2; pfam07696
742013004003	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
742013004004	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
742013004005	dimer interface [polypeptide binding]; other site
742013004006	phosphorylation site [posttranslational modification]
742013004007	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
742013004008	ATP binding site [chemical binding]; other site
742013004009	Mg2+ binding site [ion binding]; other site
742013004010	G-X-G motif; other site
742013004011	7TMR-DISM extracellular 2; Region: 7TMR-DISMED2; pfam07696
742013004012	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
742013004013	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
742013004014	dimer interface [polypeptide binding]; other site
742013004015	phosphorylation site [posttranslational modification]
742013004016	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
742013004017	ATP binding site [chemical binding]; other site
742013004018	Mg2+ binding site [ion binding]; other site
742013004019	G-X-G motif; other site
742013004020	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
742013004021	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
742013004022	active site
742013004023	phosphorylation site [posttranslational modification]
742013004024	intermolecular recognition site; other site
742013004025	dimerization interface [polypeptide binding]; other site
742013004026	Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862
742013004027	DNA binding site [nucleotide binding]
742013004028	IPTL-CTERM protein sorting domain; Region: IPTL_CTERM; TIGR04174
742013004029	Bestrophin, RFP-TM, chloride channel; Region: Bestrophin; pfam01062
742013004030	pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203
742013004031	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
742013004032	active site
742013004033	pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204
742013004034	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
742013004035	active site
742013004036	hypothetical protein; Provisional; Region: PRK11239
742013004037	Protein of unknown function, DUF480; Region: DUF480; pfam04337
742013004038	phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647
742013004039	Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645
742013004040	active site
742013004041	substrate binding site [chemical binding]; other site
742013004042	cosubstrate binding site; other site
742013004043	catalytic site [active]
742013004044	Protein of unknown function (DUF1653); Region: DUF1653; pfam07866
742013004045	NOL1/NOP2/sun family; Region: Nol1_Nop2_Fmu; pfam01189
742013004046	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
742013004047	S-adenosylmethionine binding site [chemical binding]; other site
742013004048	The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505
742013004049	Fatty acid desaturase; Region: FA_desaturase; pfam00487
742013004050	Di-iron ligands [ion binding]; other site
742013004051	Transposase; Region: DDE_Tnp_ISL3; pfam01610
742013004052	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
742013004053	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
742013004054	DNA-binding site [nucleotide binding]; DNA binding site
742013004055	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
742013004056	pyridoxal 5'-phosphate binding site [chemical binding]; other site
742013004057	homodimer interface [polypeptide binding]; other site
742013004058	catalytic residue [active]
742013004059	50S ribosomal protein L33; Validated; Region: rpmG; PRK00595
742013004060	50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359
742013004061	thioredoxin reductase; Provisional; Region: PRK10262
742013004062	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
742013004063	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
742013004064	Domain of unknown function (DUF4117); Region: DUF4117; pfam13491
742013004065	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
742013004066	Ftsk gamma domain; Region: Ftsk_gamma; pfam09397
742013004067	lipoprotein chaperone; Reviewed; Region: lolA; PRK00031
742013004068	Outer membrane lipoprotein carrier protein LolA; Region: LolA; pfam03548
742013004069	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
742013004070	dimerization interface [polypeptide binding]; other site
742013004071	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
742013004072	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
742013004073	dimer interface [polypeptide binding]; other site
742013004074	putative CheW interface [polypeptide binding]; other site
742013004075	Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547
742013004076	recombination factor protein RarA; Reviewed; Region: PRK13342
742013004077	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
742013004078	Walker A motif; other site
742013004079	ATP binding site [chemical binding]; other site
742013004080	Walker B motif; other site
742013004081	arginine finger; other site
742013004082	MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
742013004083	Predicted transcriptional regulators [Transcription]; Region: COG1733
742013004084	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
742013004085	Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028
742013004086	classical (c) SDR, subgroup  10; Region: SDR_c10; cd05373
742013004087	putative NAD(P) binding site [chemical binding]; other site
742013004088	active site
742013004089	2-hydroxychromene-2-carboxylate isomerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NahD; COG3917
742013004090	DsbA family, 2-hydroxychromene-2-carboxylate (HCCA) isomerase subfamily; HCCA isomerase is a glutathione (GSH) dependent enzyme involved in the naphthalene catabolic pathway. It converts HCCA, a hemiketal formed spontaneously after ring cleavage of 1; Region: DsbA_HCCA_Iso; cd03022
742013004091	putative catalytic residue [active]
742013004092	Uncharacterized conserved protein [Function unknown]; Region: COG3791
742013004093	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
742013004094	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
742013004095	TM-ABC transporter signature motif; other site
742013004096	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
742013004097	TM-ABC transporter signature motif; other site
742013004098	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
742013004099	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
742013004100	Walker A/P-loop; other site
742013004101	ATP binding site [chemical binding]; other site
742013004102	Q-loop/lid; other site
742013004103	ABC transporter signature motif; other site
742013004104	Walker B; other site
742013004105	D-loop; other site
742013004106	H-loop/switch region; other site
742013004107	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
742013004108	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
742013004109	Walker A/P-loop; other site
742013004110	ATP binding site [chemical binding]; other site
742013004111	Q-loop/lid; other site
742013004112	ABC transporter signature motif; other site
742013004113	Walker B; other site
742013004114	D-loop; other site
742013004115	H-loop/switch region; other site
742013004116	Protein of unknown function, DUF486; Region: DUF486; pfam04342
742013004117	Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392
742013004118	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
742013004119	TM2 domain; Region: TM2; pfam05154
742013004120	Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247
742013004121	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
742013004122	Coenzyme A binding pocket [chemical binding]; other site
742013004123	30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040
742013004124	16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122
742013004125	RimM N-terminal domain; Region: RimM; pfam01782
742013004126	PRC-barrel domain; Region: PRC; pfam05239
742013004127	tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026
742013004128	50S ribosomal protein L19; Provisional; Region: rplS; PRK05338
742013004129	Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426
742013004130	putative active site [active]
742013004131	putative CoA binding site [chemical binding]; other site
742013004132	nudix motif; other site
742013004133	metal binding site [ion binding]; metal-binding site
742013004134	CobD/Cbib protein; Region: CobD_Cbib; cl00561
742013004135	GTPase RsgA; Reviewed; Region: PRK00098
742013004136	S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466
742013004137	RNA binding site [nucleotide binding]; other site
742013004138	homodimer interface [polypeptide binding]; other site
742013004139	Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854
742013004140	GTPase/Zn-binding domain interface [polypeptide binding]; other site
742013004141	GTP/Mg2+ binding site [chemical binding]; other site
742013004142	G4 box; other site
742013004143	G5 box; other site
742013004144	G1 box; other site
742013004145	Switch I region; other site
742013004146	G2 box; other site
742013004147	G3 box; other site
742013004148	Switch II region; other site
742013004149	PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH  (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme.  DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488
742013004150	aromatic arch; other site
742013004151	DCoH dimer interaction site [polypeptide binding]; other site
742013004152	DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site
742013004153	DCoH tetramer interaction site [polypeptide binding]; other site
742013004154	substrate binding site [chemical binding]; other site
742013004155	Peptidase family M48; Region: Peptidase_M48; pfam01435
742013004156	DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135
742013004157	DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847
742013004158	catalytic site [active]
742013004159	putative active site [active]
742013004160	putative substrate binding site [chemical binding]; other site
742013004161	dimer interface [polypeptide binding]; other site
742013004162	helicase 45; Provisional; Region: PTZ00424
742013004163	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
742013004164	ATP binding site [chemical binding]; other site
742013004165	Mg++ binding site [ion binding]; other site
742013004166	motif III; other site
742013004167	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
742013004168	nucleotide binding region [chemical binding]; other site
742013004169	ATP-binding site [chemical binding]; other site
742013004170	PAS domain; Region: PAS_9; pfam13426
742013004171	PAS domain; Region: PAS_9; pfam13426
742013004172	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
742013004173	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
742013004174	metal binding site [ion binding]; metal-binding site
742013004175	active site
742013004176	I-site; other site
742013004177	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
742013004178	bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102
742013004179	putative substrate translocation pore; other site
742013004180	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441
742013004181	guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05458
742013004182	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
742013004183	active site
742013004184	DNA helicase II; Region: uvrD; TIGR01075
742013004185	Part of AAA domain; Region: AAA_19; pfam13245
742013004186	Family description; Region: UvrD_C_2; pfam13538
742013004187	Domain of unknown function (DUF4198); Region: DUF4198; pfam10670
742013004188	Predicted phosphatase [General function prediction only]; Region: PhoX; COG3211
742013004189	Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334
742013004190	Homoserine Kinase, type II. Homoserine kinase is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: HomoserineK_II; cd05153
742013004191	putative active site [active]
742013004192	putative substrate binding site [chemical binding]; other site
742013004193	ATP binding site [chemical binding]; other site
742013004194	Protein of unknown function (DUF2782); Region: DUF2782; pfam11191
742013004195	DNA polymerase I; Provisional; Region: PRK05755
742013004196	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
742013004197	active site
742013004198	metal binding site 1 [ion binding]; metal-binding site
742013004199	putative 5' ssDNA interaction site; other site
742013004200	metal binding site 3; metal-binding site
742013004201	metal binding site 2 [ion binding]; metal-binding site
742013004202	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
742013004203	putative DNA binding site [nucleotide binding]; other site
742013004204	putative metal binding site [ion binding]; other site
742013004205	DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139
742013004206	active site
742013004207	substrate binding site [chemical binding]; other site
742013004208	catalytic site [active]
742013004209	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
742013004210	active site
742013004211	DNA binding site [nucleotide binding]
742013004212	catalytic site [active]
742013004213	Dienelactone hydrolase family; Region: DLH; pfam01738
742013004214	Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428
742013004215	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
742013004216	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
742013004217	active site
742013004218	phosphorylation site [posttranslational modification]
742013004219	intermolecular recognition site; other site
742013004220	dimerization interface [polypeptide binding]; other site
742013004221	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
742013004222	DNA binding residues [nucleotide binding]
742013004223	dimerization interface [polypeptide binding]; other site
742013004224	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4564
742013004225	Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049
742013004226	Histidine kinase; Region: HisKA_3; pfam07730
742013004227	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
742013004228	ATP binding site [chemical binding]; other site
742013004229	Mg2+ binding site [ion binding]; other site
742013004230	G-X-G motif; other site
742013004231	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
742013004232	homotrimer interaction site [polypeptide binding]; other site
742013004233	putative active site [active]
742013004234	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
742013004235	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
742013004236	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
742013004237	catalytic residue [active]
742013004238	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
742013004239	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
742013004240	active site
742013004241	phosphorylation site [posttranslational modification]
742013004242	intermolecular recognition site; other site
742013004243	dimerization interface [polypeptide binding]; other site
742013004244	LytTr DNA-binding domain; Region: LytTR; smart00850
742013004245	Histidine kinase; Region: His_kinase; pfam06580
742013004246	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
742013004247	ATP binding site [chemical binding]; other site
742013004248	Mg2+ binding site [ion binding]; other site
742013004249	G-X-G motif; other site
742013004250	argininosuccinate lyase; Provisional; Region: PRK00855
742013004251	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
742013004252	active sites [active]
742013004253	tetramer interface [polypeptide binding]; other site
742013004254	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
742013004255	Rhomboid family; Region: Rhomboid; pfam01694
742013004256	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
742013004257	MG2 domain; Region: A2M_N; pfam01835
742013004258	Alpha-2-macroglobulin family N-terminal region; Region: A2M_N_2; pfam07703
742013004259	Alpha-2-macroglobulin family; Region: A2M; pfam00207
742013004260	Protein of unknown function (DUF2867); Region: DUF2867; pfam11066
742013004261	BCCT family transporter; Region: BCCT; pfam02028
742013004262	DNA-binding transcriptional activator FeaR; Provisional; Region: PRK09685
742013004263	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
742013004264	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
742013004265	Amidase; Region: Amidase; pfam01425
742013004266	ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839
742013004267	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
742013004268	Walker A/P-loop; other site
742013004269	ATP binding site [chemical binding]; other site
742013004270	Q-loop/lid; other site
742013004271	ABC transporter signature motif; other site
742013004272	Walker B; other site
742013004273	D-loop; other site
742013004274	H-loop/switch region; other site
742013004275	TOBE domain; Region: TOBE_2; pfam08402
742013004276	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
742013004277	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
742013004278	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
742013004279	dimer interface [polypeptide binding]; other site
742013004280	conserved gate region; other site
742013004281	putative PBP binding loops; other site
742013004282	ABC-ATPase subunit interface; other site
742013004283	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
742013004284	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
742013004285	dimer interface [polypeptide binding]; other site
742013004286	conserved gate region; other site
742013004287	putative PBP binding loops; other site
742013004288	ABC-ATPase subunit interface; other site
742013004289	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
742013004290	active site
742013004291	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
742013004292	putative catalytic site [active]
742013004293	putative metal binding site [ion binding]; other site
742013004294	putative phosphate binding site [ion binding]; other site
742013004295	Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247
742013004296	penicillin-binding protein 1C; Region: PBP_1c; TIGR02073
742013004297	Transglycosylase; Region: Transgly; pfam00912
742013004298	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
742013004299	Penicillin-Binding Protein C-terminus Family; Region: BiPBP_C; pfam06832
742013004300	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
742013004301	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
742013004302	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181
742013004303	Cupin domain; Region: Cupin_2; pfam07883
742013004304	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
742013004305	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
742013004306	putative DNA binding site [nucleotide binding]; other site
742013004307	putative Zn2+ binding site [ion binding]; other site
742013004308	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
742013004309	Coenzyme A binding pocket [chemical binding]; other site
742013004310	L-lactate permease; Region: Lactate_perm; cl00701
742013004311	L-lactate permease [Energy production and conversion]; Region: LldP; COG1620
742013004312	Isopentenyl diphosphate isomerase (BS_ypgA, MTH48 and related proteins) [Coenzyme transport and metabolism]; Region: idi; COG1304
742013004313	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
742013004314	phosphate binding site [ion binding]; other site
742013004315	2-isopropylmalate synthase; Validated; Region: PRK03739
742013004316	Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942
742013004317	active site
742013004318	catalytic residues [active]
742013004319	metal binding site [ion binding]; metal-binding site
742013004320	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917
742013004321	Cupin domain; Region: Cupin_2; cl17218
742013004322	Helix-turn-helix domain; Region: HTH_18; pfam12833
742013004323	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
742013004324	Protein of unknown function (DUF3455); Region: DUF3455; pfam11937
742013004325	RNA polymerase sigma factor; Provisional; Region: PRK12514
742013004326	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
742013004327	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
742013004328	DNA binding residues [nucleotide binding]
742013004329	Anti-sigma-K factor rskA; Region: RskA; pfam10099
742013004330	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
742013004331	active site
742013004332	DNA polymerase IV; Validated; Region: PRK02406
742013004333	DNA binding site [nucleotide binding]
742013004334	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
742013004335	PAS domain; Region: PAS_9; pfam13426
742013004336	putative active site [active]
742013004337	heme pocket [chemical binding]; other site
742013004338	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
742013004339	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
742013004340	dimer interface [polypeptide binding]; other site
742013004341	putative CheW interface [polypeptide binding]; other site
742013004342	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2904
742013004343	7-cyano-7-deazaguanine reductase; Provisional; Region: queF; PRK11792
742013004344	Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780
742013004345	Prolyl 4-hydroxylase alpha subunit homologues; Region: P4Hc; smart00702
742013004346	hypothetical protein; Validated; Region: PRK02101
742013004347	Ribonucleases G and E [Translation, ribosomal structure and biogenesis]; Region: CafA; COG1530
742013004348	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
742013004349	homodimer interface [polypeptide binding]; other site
742013004350	oligonucleotide binding site [chemical binding]; other site
742013004351	23S rRNA pseudouridylate synthase C; Provisional; Region: PRK11025
742013004352	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
742013004353	RNA binding surface [nucleotide binding]; other site
742013004354	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
742013004355	active site
742013004356	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
742013004357	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
742013004358	motif II; other site
742013004359	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
742013004360	iron-sulfur cluster [ion binding]; other site
742013004361	[2Fe-2S] cluster binding site [ion binding]; other site
742013004362	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
742013004363	signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706
742013004364	tandem repeat interface [polypeptide binding]; other site
742013004365	oligomer interface [polypeptide binding]; other site
742013004366	active site residues [active]
742013004367	Uncharacterized subfamily of the tetrapyrrole methylase family similar to ribosomal RNA small subunit methyltransferase I (RsmI); Region: RsmI_like; cd11649
742013004368	putative SAM binding site [chemical binding]; other site
742013004369	homodimer interface [polypeptide binding]; other site
742013004370	Maf-like protein; Region: Maf; pfam02545
742013004371	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
742013004372	active site
742013004373	dimer interface [polypeptide binding]; other site
742013004374	Uncharacterized ACR, COG1399; Region: DUF177; cl00616
742013004375	50S ribosomal protein L32; Validated; Region: rpmF; PRK01110
742013004376	putative phosphate acyltransferase; Provisional; Region: PRK05331
742013004377	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
742013004378	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
742013004379	dimer interface [polypeptide binding]; other site
742013004380	active site
742013004381	CoA binding pocket [chemical binding]; other site
742013004382	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
742013004383	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
742013004384	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
742013004385	3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830
742013004386	NAD(P) binding site [chemical binding]; other site
742013004387	homotetramer interface [polypeptide binding]; other site
742013004388	homodimer interface [polypeptide binding]; other site
742013004389	active site
742013004390	acyl carrier protein; Provisional; Region: acpP; PRK00982
742013004391	beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150
742013004392	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
742013004393	dimer interface [polypeptide binding]; other site
742013004394	active site
742013004395	RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652
742013004396	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
742013004397	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
742013004398	DNA binding residues [nucleotide binding]
742013004399	Anti sigma-E protein RseA, N-terminal domain; Region: RseA_N; pfam03872
742013004400	periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037
742013004401	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
742013004402	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
742013004403	protein binding site [polypeptide binding]; other site
742013004404	GTP-binding protein LepA; Provisional; Region: PRK05433
742013004405	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
742013004406	G1 box; other site
742013004407	putative GEF interaction site [polypeptide binding]; other site
742013004408	GTP/Mg2+ binding site [chemical binding]; other site
742013004409	Switch I region; other site
742013004410	G2 box; other site
742013004411	G3 box; other site
742013004412	Switch II region; other site
742013004413	G4 box; other site
742013004414	G5 box; other site
742013004415	lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699
742013004416	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
742013004417	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
742013004418	signal peptidase I; Provisional; Region: PRK10861
742013004419	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
742013004420	Catalytic site [active]
742013004421	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
742013004422	ribonuclease III; Reviewed; Region: rnc; PRK00102
742013004423	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
742013004424	dimerization interface [polypeptide binding]; other site
742013004425	active site
742013004426	metal binding site [ion binding]; metal-binding site
742013004427	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
742013004428	dsRNA binding site [nucleotide binding]; other site
742013004429	GTPase Era; Reviewed; Region: era; PRK00089
742013004430	E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163
742013004431	G1 box; other site
742013004432	GTP/Mg2+ binding site [chemical binding]; other site
742013004433	Switch I region; other site
742013004434	G2 box; other site
742013004435	Switch II region; other site
742013004436	G3 box; other site
742013004437	G4 box; other site
742013004438	G5 box; other site
742013004439	KH domain; Region: KH_2; pfam07650
742013004440	DNA repair protein RecO; Reviewed; Region: recO; PRK00085
742013004441	Recombination protein O N terminal; Region: RecO_N; pfam11967
742013004442	Recombination protein O C terminal; Region: RecO_C; pfam02565
742013004443	Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003
742013004444	active site
742013004445	hydrophilic channel; other site
742013004446	dimerization interface [polypeptide binding]; other site
742013004447	catalytic residues [active]
742013004448	active site lid [active]
742013004449	4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070
742013004450	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
742013004451	beta-hexosaminidase; Provisional; Region: PRK05337
742013004452	Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204
742013004453	6-phosphofructokinase; Region: PFKA_ATP; TIGR02482
742013004454	active site
742013004455	ADP/pyrophosphate binding site [chemical binding]; other site
742013004456	dimerization interface [polypeptide binding]; other site
742013004457	allosteric effector site; other site
742013004458	fructose-1,6-bisphosphate binding site; other site
742013004459	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
742013004460	DNA-binding site [nucleotide binding]; DNA binding site
742013004461	RNA-binding motif; other site
742013004462	Protein of unknown function (DUF1294); Region: DUF1294; pfam06961
742013004463	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4339
742013004464	phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288
742013004465	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
742013004466	ATP-grasp domain; Region: ATP-grasp; pfam02222
742013004467	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
742013004468	Mechanosensitive ion channel; Region: MS_channel; pfam00924
742013004469	Response regulator receiver domain; Region: Response_reg; pfam00072
742013004470	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
742013004471	active site
742013004472	phosphorylation site [posttranslational modification]
742013004473	intermolecular recognition site; other site
742013004474	dimerization interface [polypeptide binding]; other site
742013004475	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
742013004476	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
742013004477	metal binding site [ion binding]; metal-binding site
742013004478	active site
742013004479	I-site; other site
742013004480	lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484
742013004481	LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322
742013004482	dimer interface [polypeptide binding]; other site
742013004483	putative anticodon binding site; other site
742013004484	Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775
742013004485	motif 1; other site
742013004486	active site
742013004487	motif 2; other site
742013004488	motif 3; other site
742013004489	Uncharacterized protein, similar to the N-terminal domain of Lon protease [General function prediction only]; Region: COG2802
742013004490	YGGT family; Region: YGGT; pfam02325
742013004491	YGGT family; Region: YGGT; pfam02325
742013004492	acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654
742013004493	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
742013004494	tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200
742013004495	Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724
742013004496	substrate binding site [chemical binding]; other site
742013004497	active site
742013004498	catalytic residues [active]
742013004499	heterodimer interface [polypeptide binding]; other site
742013004500	tryptophan synthase, beta subunit; Region: trpB; TIGR00263
742013004501	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
742013004502	pyridoxal 5'-phosphate binding site [chemical binding]; other site
742013004503	catalytic residue [active]
742013004504	Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405
742013004505	active site
742013004506	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
742013004507	Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA; Region: PseudoU_synth_EcTruA; cd02570
742013004508	dimerization interface 3.5A [polypeptide binding]; other site
742013004509	active site
742013004510	FimV N-terminal domain; Region: FimV_core; TIGR03505
742013004511	FimV C-terminal domain; Region: FimV_Cterm; TIGR03504
742013004512	aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK06598
742013004513	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
742013004514	3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772
742013004515	tartrate dehydrogenase; Region: TTC; TIGR02089
742013004516	isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641
742013004517	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
742013004518	substrate binding site [chemical binding]; other site
742013004519	Predicted small secreted protein [Function unknown]; Region: COG5510
742013004520	3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
742013004521	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
742013004522	substrate binding site [chemical binding]; other site
742013004523	ligand binding site [chemical binding]; other site
742013004524	Transcriptional regulator [Transcription]; Region: LysR; COG0583
742013004525	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
742013004526	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_1; cd08421
742013004527	putative dimerization interface [polypeptide binding]; other site
742013004528	Sel1-like repeats; Region: SEL1; smart00671
742013004529	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
742013004530	Sel1-like repeats; Region: SEL1; smart00671
742013004531	Sel1-like repeats; Region: SEL1; smart00671
742013004532	Sel1-like repeats; Region: SEL1; smart00671
742013004533	Sel1-like repeats; Region: SEL1; smart00671
742013004534	Sel1-like repeats; Region: SEL1; smart00671
742013004535	chaperone protein DnaJ; Provisional; Region: PRK10767
742013004536	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
742013004537	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
742013004538	Zn binding sites [ion binding]; other site
742013004539	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
742013004540	dimer interface [polypeptide binding]; other site
742013004541	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
742013004542	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
742013004543	nucleotide binding site [chemical binding]; other site
742013004544	GrpE; Region: GrpE; pfam01025
742013004545	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
742013004546	dimer interface [polypeptide binding]; other site
742013004547	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
742013004548	30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453
742013004549	Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930
742013004550	30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391
742013004551	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
742013004552	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
742013004553	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
742013004554	replicative DNA helicase; Region: DnaB; TIGR00665
742013004555	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
742013004556	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
742013004557	Walker A motif; other site
742013004558	ATP binding site [chemical binding]; other site
742013004559	Walker B motif; other site
742013004560	DNA binding loops [nucleotide binding]
742013004561	NYN ribonuclease and ATPase of PhoH family domains [General    function prediction only]; Region: COG1875
742013004562	PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883
742013004563	putative active site [active]
742013004564	PhoH-like protein; Region: PhoH; pfam02562
742013004565	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
742013004566	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
742013004567	catalytic triad [active]
742013004568	Xcc1710_like family, specific to proteobacteria. Xcc1710 is a hypothetical protein from Xanthomonas campestris pv. campestris str. ATCC 33913, similar to Mth938, a hypothetical protein encoded by the Methanobacterium thermoautotrophicum (Mth) genome; Region: Xcc1710_like; cd05560
742013004569	aminotransferase AlaT; Validated; Region: PRK09265
742013004570	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
742013004571	pyridoxal 5'-phosphate binding site [chemical binding]; other site
742013004572	homodimer interface [polypeptide binding]; other site
742013004573	catalytic residue [active]
742013004574	homoserine dehydrogenase; Provisional; Region: PRK06349
742013004575	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
742013004576	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
742013004577	ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881
742013004578	Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498
742013004579	Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560
742013004580	pyridoxal 5'-phosphate binding site [chemical binding]; other site
742013004581	catalytic residue [active]
742013004582	Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116
742013004583	Walker A motif; other site
742013004584	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
742013004585	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
742013004586	dimer interface [polypeptide binding]; other site
742013004587	putative functional site; other site
742013004588	putative MPT binding site; other site
742013004589	Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754
742013004590	MoaE interaction surface [polypeptide binding]; other site
742013004591	MoeB interaction surface [polypeptide binding]; other site
742013004592	thiocarboxylated glycine; other site
742013004593	Recombinase; Region: Recombinase; pfam07508
742013004594	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
742013004595	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
742013004596	dimer interface [polypeptide binding]; other site
742013004597	active site
742013004598	catalytic residue [active]
742013004599	MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756
742013004600	MoaE homodimer interface [polypeptide binding]; other site
742013004601	MoaD interaction [polypeptide binding]; other site
742013004602	active site residues [active]
742013004603	EamA-like transporter family; Region: EamA; pfam00892
742013004604	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
742013004605	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
742013004606	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
742013004607	ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346
742013004608	Clp amino terminal domain; Region: Clp_N; pfam02861
742013004609	Clp amino terminal domain; Region: Clp_N; pfam02861
742013004610	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
742013004611	Walker A motif; other site
742013004612	ATP binding site [chemical binding]; other site
742013004613	Walker B motif; other site
742013004614	arginine finger; other site
742013004615	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
742013004616	Walker A motif; other site
742013004617	ATP binding site [chemical binding]; other site
742013004618	Walker B motif; other site
742013004619	arginine finger; other site
742013004620	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
742013004621	Coniferyl aldehyde dehydrogenase-like; Region: ALDH_CALDH_CalB; cd07133
742013004622	NAD(P) binding site [chemical binding]; other site
742013004623	catalytic residues [active]
742013004624	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
742013004625	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
742013004626	Coenzyme A binding pocket [chemical binding]; other site
742013004627	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
742013004628	Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis]; Region: HemK; COG2890
742013004629	S-adenosylmethionine binding site [chemical binding]; other site
742013004630	tRNA-dihydrouridine synthase C; Provisional; Region: PRK10550
742013004631	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
742013004632	FMN binding site [chemical binding]; other site
742013004633	active site
742013004634	catalytic residues [active]
742013004635	substrate binding site [chemical binding]; other site
742013004636	Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502
742013004637	Putative catalytic domain, repeat 1, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_1; cd09111
742013004638	putative active site [active]
742013004639	catalytic site [active]
742013004640	Putative catalytic domain, repeat 2, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_2; cd09113
742013004641	Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502
742013004642	putative active site [active]
742013004643	catalytic site [active]
742013004644	bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase; Provisional; Region: ribD; PRK10786
742013004645	Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284
742013004646	catalytic motif [active]
742013004647	Zn binding site [ion binding]; other site
742013004648	RibD C-terminal domain; Region: RibD_C; cl17279
742013004649	Tfp pilus assembly protein PilE [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilE; COG4968
742013004650	prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532
742013004651	Tfp pilus assembly protein, tip-associated adhesin PilY1 [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilY1; COG3419
742013004652	Neisseria PilC beta-propeller domain; Region: Neisseria_PilC; pfam05567
742013004653	PilX N-terminal; Region: PilX_N; pfam14341
742013004654	Type IV pilus assembly protein PilX C-term; Region: PilX; pfam13681
742013004655	Tfp pilus assembly protein PilW [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilW; COG4966
742013004656	type IV pilus modification protein PilV; Region: type_IV_pilV; TIGR02523
742013004657	Type II transport protein GspH; Region: GspH; pfam12019
742013004658	Tfp pilus assembly protein PilE [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilE; COG4968
742013004659	prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532
742013004660	Neisseria PilC beta-propeller domain; Region: Neisseria_PilC; pfam05567
742013004661	Tfp pilus assembly protein PilX [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilX; COG4726
742013004662	Type IV pilus assembly protein PilX C-term; Region: PilX; pfam13681
742013004663	type IV pilus modification protein PilV; Region: type_IV_pilV; TIGR02523
742013004664	Type II transport protein GspH; Region: GspH; pfam12019
742013004665	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
742013004666	16S/18S rRNA binding site [nucleotide binding]; other site
742013004667	S13e-L30e interaction site [polypeptide binding]; other site
742013004668	25S rRNA binding site [nucleotide binding]; other site
742013004669	polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824
742013004670	Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363
742013004671	RNase E interface [polypeptide binding]; other site
742013004672	trimer interface [polypeptide binding]; other site
742013004673	Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726
742013004674	Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364
742013004675	RNase E interface [polypeptide binding]; other site
742013004676	trimer interface [polypeptide binding]; other site
742013004677	active site
742013004678	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
742013004679	putative nucleic acid binding region [nucleotide binding]; other site
742013004680	G-X-X-G motif; other site
742013004681	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
742013004682	RNA binding site [nucleotide binding]; other site
742013004683	domain interface; other site
742013004684	putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824
742013004685	PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276
742013004686	NAD(P) binding site [chemical binding]; other site
742013004687	triosephosphate isomerase; Provisional; Region: PRK14567
742013004688	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
742013004689	substrate binding site [chemical binding]; other site
742013004690	dimer interface [polypeptide binding]; other site
742013004691	catalytic triad [active]
742013004692	Preprotein translocase SecG subunit; Region: SecG; pfam03840
742013004693	NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602
742013004694	NADH dehydrogenase subunit B; Validated; Region: PRK06411
742013004695	NADH dehydrogenase subunit C; Provisional; Region: PRK06074
742013004696	NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961
742013004697	NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649
742013004698	NADH dehydrogenase subunit D; Validated; Region: PRK06075
742013004699	NADH dehydrogenase subunit E; Validated; Region: PRK07539
742013004700	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064
742013004701	putative dimer interface [polypeptide binding]; other site
742013004702	[2Fe-2S] cluster binding site [ion binding]; other site
742013004703	NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894
742013004704	SLBB domain; Region: SLBB; pfam10531
742013004705	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928
742013004706	NADH dehydrogenase subunit G; Validated; Region: PRK09129
742013004707	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
742013004708	catalytic loop [active]
742013004709	iron binding site [ion binding]; other site
742013004710	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588
742013004711	MopB_NDH-1_NuoG2: The second domain of the NuoG subunit of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1), found in beta- and gammaproteobacteria. The NDH-1 is the first energy-transducting complex in the respiratory chain and functions as...; Region: MopB_NDH-1_NuoG2; cd02772
742013004712	NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076
742013004713	Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650
742013004714	NADH dehydrogenase subunit I; Provisional; Region: PRK05888
742013004715	4Fe-4S binding domain; Region: Fer4; pfam00037
742013004716	4Fe-4S binding domain; Region: Fer4; pfam00037
742013004717	NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638
742013004718	NADH dehydrogenase subunit J; Provisional; Region: PRK06433
742013004719	NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715
742013004720	NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590
742013004721	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662
742013004722	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
742013004723	NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846
742013004724	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
742013004725	NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777
742013004726	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
742013004727	Protein of unknown function (DUF2818); Region: DUF2818; pfam10993
742013004728	Protein of unknown function (DUF1178); Region: DUF1178; pfam06676
742013004729	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
742013004730	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
742013004731	Walker A/P-loop; other site
742013004732	ATP binding site [chemical binding]; other site
742013004733	Q-loop/lid; other site
742013004734	ABC transporter signature motif; other site
742013004735	Walker B; other site
742013004736	D-loop; other site
742013004737	H-loop/switch region; other site
742013004738	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
742013004739	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
742013004740	Walker A/P-loop; other site
742013004741	ATP binding site [chemical binding]; other site
742013004742	Q-loop/lid; other site
742013004743	ABC transporter signature motif; other site
742013004744	Walker B; other site
742013004745	D-loop; other site
742013004746	H-loop/switch region; other site
742013004747	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
742013004748	Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327
742013004749	putative ligand binding site [chemical binding]; other site
742013004750	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
742013004751	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
742013004752	TM-ABC transporter signature motif; other site
742013004753	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
742013004754	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
742013004755	TM-ABC transporter signature motif; other site
742013004756	Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668
742013004757	Uncharacterized protein family (UPF0156); Region: RHH_2; cl17383
742013004758	Hydroxyneurosporene synthase (CrtC); Region: CrtC; pfam07143
742013004759	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
742013004760	Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342
742013004761	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
742013004762	catalytic residue [active]
742013004763	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
742013004764	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
742013004765	FtsX-like permease family; Region: FtsX; pfam02687
742013004766	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
742013004767	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
742013004768	Walker A/P-loop; other site
742013004769	ATP binding site [chemical binding]; other site
742013004770	Q-loop/lid; other site
742013004771	ABC transporter signature motif; other site
742013004772	Walker B; other site
742013004773	D-loop; other site
742013004774	H-loop/switch region; other site
742013004775	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
742013004776	tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091
742013004777	drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710
742013004778	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
742013004779	putative substrate translocation pore; other site
742013004780	Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897
742013004781	Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448
742013004782	active site residue [active]
742013004783	Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449
742013004784	active site residue [active]
742013004785	Sulphur transport; Region: Sulf_transp; pfam04143
742013004786	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
742013004787	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
742013004788	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
742013004789	Ankyrin repeats (many copies); Region: Ank_4; pfam13637
742013004790	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
742013004791	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
742013004792	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
742013004793	MGS-like domain. This domain composes the whole protein of methylglyoxal synthetase, which catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The family also includes the C-terminal domain in carbamoyl phosphate...; Region: MGS-like; cl00245
742013004794	substrate binding site [chemical binding]; other site
742013004795	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
742013004796	Beta-lactamase; Region: Beta-lactamase; pfam00144
742013004797	Putative Ig domain; Region: He_PIG; pfam05345
742013004798	IPTL-CTERM protein sorting domain; Region: IPTL_CTERM; TIGR04174
742013004799	glutamate dehydrogenase; Provisional; Region: PRK09414
742013004800	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
742013004801	NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313
742013004802	NAD(P) binding site [chemical binding]; other site
742013004803	Transcriptional regulator [Transcription]; Region: LysR; COG0583
742013004804	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
742013004805	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472
742013004806	putative effector binding pocket; other site
742013004807	putative dimerization interface [polypeptide binding]; other site
742013004808	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
742013004809	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
742013004810	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
742013004811	HlyD family secretion protein; Region: HlyD_3; pfam13437
742013004812	AcrB/AcrD/AcrF family; Region: ACR_tran; pfam00873
742013004813	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
742013004814	putative DNA-binding transcriptional regulator; Provisional; Region: PRK09791
742013004815	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
742013004816	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
742013004817	dimerization interface [polypeptide binding]; other site
742013004818	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
742013004819	M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666
742013004820	metal binding site [ion binding]; metal-binding site
742013004821	putative dimer interface [polypeptide binding]; other site
742013004822	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
742013004823	DNA mismatch repair protein MutL; Region: mutl; TIGR00585
742013004824	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
742013004825	ATP binding site [chemical binding]; other site
742013004826	Mg2+ binding site [ion binding]; other site
742013004827	G-X-G motif; other site
742013004828	MutL_Trans_MutL: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to Escherichia coli MutL.  EcMutL belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family.  This transducer domain is homologous to the second...; Region: MutL_Trans_MutL; cd03482
742013004829	ATP binding site [chemical binding]; other site
742013004830	MutL C terminal dimerisation domain; Region: MutL_C; pfam08676
742013004831	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
742013004832	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
742013004833	AMIN domain; Region: AMIN; pfam11741
742013004834	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
742013004835	active site
742013004836	metal binding site [ion binding]; metal-binding site
742013004837	Predicted ATPase or kinase [General function prediction only]; Region: COG0802
742013004838	epoxyqueuosine reductase; Region: TIGR00276
742013004839	Domain of unknown function (DUF1730); Region: DUF1730; pfam08331
742013004840	PAS domain; Region: PAS_9; pfam13426
742013004841	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
742013004842	PAS fold; Region: PAS_3; pfam08447
742013004843	putative active site [active]
742013004844	heme pocket [chemical binding]; other site
742013004845	PAS domain; Region: PAS_9; pfam13426
742013004846	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
742013004847	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
742013004848	metal binding site [ion binding]; metal-binding site
742013004849	active site
742013004850	I-site; other site
742013004851	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
742013004852	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
742013004853	Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592
742013004854	agmatinase; Region: agmatinase; TIGR01230
742013004855	oligomer interface [polypeptide binding]; other site
742013004856	putative active site [active]
742013004857	Mn binding site [ion binding]; other site
742013004858	Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u3; cd11479
742013004859	Na binding site [ion binding]; other site
742013004860	Transcriptional regulator [Transcription]; Region: LysR; COG0583
742013004861	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
742013004862	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
742013004863	dimerization interface [polypeptide binding]; other site
742013004864	Predicted permeases [General function prediction only]; Region: COG0679
742013004865	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181
742013004866	site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283
742013004867	XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798
742013004868	active site
742013004869	Int/Topo IB signature motif; other site
742013004870	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181
742013004871	Predicted signal transduction protein containing EAL and modified HD-GYP domains [Signal transduction mechanisms]; Region: COG3434
742013004872	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
742013004873	Predicted signal transduction protein containing EAL and modified HD-GYP domains [Signal transduction mechanisms]; Region: COG3434
742013004874	EAL domain; Region: EAL; pfam00563
742013004875	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657
742013004876	dinuclear metal binding motif [ion binding]; other site
742013004877	Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663
742013004878	Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645
742013004879	trimer interface [polypeptide binding]; other site
742013004880	putative metal binding site [ion binding]; other site
742013004881	Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114
742013004882	Heat shock protein 33 (Hsp33):  Cytosolic protein that acts as a molecular chaperone under oxidative conditions.  In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498
742013004883	dimerization interface [polypeptide binding]; other site
742013004884	domain crossover interface; other site
742013004885	redox-dependent activation switch; other site
742013004886	Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919
742013004887	Septum formation initiator; Region: DivIC; cl17659
742013004888	enolase; Provisional; Region: eno; PRK00077
742013004889	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
742013004890	dimer interface [polypeptide binding]; other site
742013004891	metal binding site [ion binding]; metal-binding site
742013004892	substrate binding pocket [chemical binding]; other site
742013004893	Uncharacterized conserved protein [Function unknown]; Region: COG5470
742013004894	2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198
742013004895	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
742013004896	CTP synthetase; Validated; Region: pyrG; PRK05380
742013004897	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
742013004898	Catalytic site [active]
742013004899	active site
742013004900	UTP binding site [chemical binding]; other site
742013004901	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
742013004902	active site
742013004903	putative oxyanion hole; other site
742013004904	catalytic triad [active]
742013004905	bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579
742013004906	Flavoprotein; Region: Flavoprotein; pfam02441
742013004907	DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127
742013004908	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
742013004909	trimer interface [polypeptide binding]; other site
742013004910	active site
742013004911	sensor protein PhoQ; Provisional; Region: PRK10815
742013004912	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
742013004913	ATP binding site [chemical binding]; other site
742013004914	Mg2+ binding site [ion binding]; other site
742013004915	G-X-G motif; other site
742013004916	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
742013004917	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
742013004918	active site
742013004919	phosphorylation site [posttranslational modification]
742013004920	intermolecular recognition site; other site
742013004921	dimerization interface [polypeptide binding]; other site
742013004922	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
742013004923	DNA binding site [nucleotide binding]
742013004924	Predicted membrane protein [Function unknown]; Region: COG3212
742013004925	Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413
742013004926	Peptidase propeptide and YPEB domain; Region: PepSY_2; pfam13670
742013004927	FKBP-type peptidyl-prolyl cis-trans isomerases 2 [Posttranslational modification, protein turnover, chaperones]; Region: SlpA; COG1047
742013004928	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
742013004929	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
742013004930	Salicylaldehyde dehydrogenase, DoxF-like; Region: ALDH_SaliADH; cd07105
742013004931	NAD(P) binding site [chemical binding]; other site
742013004932	catalytic residues [active]
742013004933	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
742013004934	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
742013004935	Uncharacterized conserved protein [Function unknown]; Region: COG2850
742013004936	Cupin-like domain; Region: Cupin_8; pfam13621
742013004937	Uncharacterized lipoprotein [Cell envelope biogenesis, outer membrane]; Region: NlpB; COG3317
742013004938	NlpB/DapX lipoprotein; Region: Lipoprotein_18; pfam06804
742013004939	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
742013004940	dihydrodipicolinate synthase; Region: dapA; TIGR00674
742013004941	dimer interface [polypeptide binding]; other site
742013004942	active site
742013004943	catalytic residue [active]
742013004944	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
742013004945	S-adenosylmethionine binding site [chemical binding]; other site
742013004946	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
742013004947	putative substrate translocation pore; other site
742013004948	Major Facilitator Superfamily; Region: MFS_1; pfam07690
742013004949	DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559
742013004950	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
742013004951	ATP binding site [chemical binding]; other site
742013004952	Mg2+ binding site [ion binding]; other site
742013004953	G-X-G motif; other site
742013004954	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
742013004955	anchoring element; other site
742013004956	dimer interface [polypeptide binding]; other site
742013004957	ATP binding site [chemical binding]; other site
742013004958	Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718
742013004959	active site
742013004960	metal binding site [ion binding]; metal-binding site
742013004961	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
742013004962	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
742013004963	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
742013004964	N-acetyl-D-glucosamine binding site [chemical binding]; other site
742013004965	catalytic residue [active]
742013004966	DNA topoisomerase IV subunit A; Validated; Region: PRK05561
742013004967	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
742013004968	CAP-like domain; other site
742013004969	active site
742013004970	primary dimer interface [polypeptide binding]; other site
742013004971	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
742013004972	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
742013004973	dimerization interface [polypeptide binding]; other site
742013004974	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
742013004975	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
742013004976	dimer interface [polypeptide binding]; other site
742013004977	putative CheW interface [polypeptide binding]; other site
742013004978	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199
742013004979	homotrimer interaction site [polypeptide binding]; other site
742013004980	putative active site [active]
742013004981	Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658
742013004982	Domain of unknown function (DUF4131); Region: DUF4131; pfam13567
742013004983	Competence protein; Region: Competence; pfam03772
742013004984	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
742013004985	Uncharacterized conserved protein [Function unknown]; Region: COG2308
742013004986	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307
742013004987	A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168
742013004988	Ureidoglycolate hydrolase; Region: Ureidogly_hydro; pfam04115
742013004989	4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332
742013004990	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
742013004991	putative substrate translocation pore; other site
742013004992	Transcriptional regulators [Transcription]; Region: FadR; COG2186
742013004993	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
742013004994	DNA-binding site [nucleotide binding]; DNA binding site
742013004995	FCD domain; Region: FCD; pfam07729
742013004996	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
742013004997	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080
742013004998	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
742013004999	ATP binding site [chemical binding]; other site
742013005000	Mg2+ binding site [ion binding]; other site
742013005001	G-X-G motif; other site
742013005002	Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193
742013005003	Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907
742013005004	heme binding site [chemical binding]; other site
742013005005	ferroxidase pore; other site
742013005006	ferroxidase diiron center [ion binding]; other site
742013005007	alkyl hydroperoxide reductase subunit C; Provisional; Region: PRK10382
742013005008	Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015
742013005009	dimer interface [polypeptide binding]; other site
742013005010	decamer (pentamer of dimers) interface [polypeptide binding]; other site
742013005011	catalytic triad [active]
742013005012	peroxidatic and resolving cysteines [active]
742013005013	alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317
742013005014	Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974
742013005015	catalytic residue [active]
742013005016	TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026
742013005017	catalytic residues [active]
742013005018	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
742013005019	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
742013005020	TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786
742013005021	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
742013005022	N-terminal plug; other site
742013005023	ligand-binding site [chemical binding]; other site
742013005024	Putative heme degradation protein [Inorganic ion transport and metabolism]; Region: HemS; COG3720
742013005025	Haemin-degrading HemS.ChuX domain; Region: HemS; pfam05171
742013005026	Haemin-degrading HemS.ChuX domain; Region: HemS; pfam05171
742013005027	Protein of unknown function (DUF2798); Region: DUF2798; pfam11391
742013005028	Transcriptional regulator [Transcription]; Region: LysR; COG0583
742013005029	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
742013005030	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
742013005031	putative effector binding pocket; other site
742013005032	dimerization interface [polypeptide binding]; other site
742013005033	PEP synthetase regulatory protein; Provisional; Region: PRK05339
742013005034	phosphoenolpyruvate synthase; Validated; Region: PRK06464
742013005035	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
742013005036	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
742013005037	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
742013005038	Domain of unknown function (DUF4212); Region: DUF4212; cl01781
742013005039	probable sodium:solute symporter, VC_2705 subfamily; Region: Na_symport_lg; TIGR03648
742013005040	probable sodium:solute symporter, VC_2705 subfamily; Region: Na_symport_lg; TIGR03648
742013005041	FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545
742013005042	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
742013005043	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220
742013005044	dimerization interface [polypeptide binding]; other site
742013005045	putative DNA binding site [nucleotide binding]; other site
742013005046	Predicted transcriptional regulators [Transcription]; Region: COG1733
742013005047	putative Zn2+ binding site [ion binding]; other site
742013005048	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181
742013005049	Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion transport and metabolism]; Region: FhuE; COG4773
742013005050	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
742013005051	N-terminal plug; other site
742013005052	ligand-binding site [chemical binding]; other site
742013005053	Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712
742013005054	FecR protein; Region: FecR; pfam04773
742013005055	RNA polymerase sigma factor FecI; Provisional; Region: PRK09651
742013005056	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
742013005057	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
742013005058	DNA binding residues [nucleotide binding]
742013005059	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3295
742013005060	PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172
742013005061	Predicted periplasmic protein (DUF2271); Region: DUF2271; pfam10029
742013005062	Domain of unknown function (DUF4198); Region: DUF4198; pfam10670
742013005063	Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477
742013005064	ApbE family; Region: ApbE; pfam02424
742013005065	Flavodoxin; Region: Flavodoxin_1; pfam00258
742013005066	Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR_like1; cd06200
742013005067	FAD binding pocket [chemical binding]; other site
742013005068	FAD binding motif [chemical binding]; other site
742013005069	catalytic residues [active]
742013005070	NAD binding pocket [chemical binding]; other site
742013005071	phosphate binding motif [ion binding]; other site
742013005072	beta-alpha-beta structure motif; other site
742013005073	enterobactin receptor protein; Provisional; Region: PRK13483
742013005074	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
742013005075	N-terminal plug; other site
742013005076	ligand-binding site [chemical binding]; other site
742013005077	Ketopantoate reductase [Coenzyme metabolism]; Region: ApbA; COG1893
742013005078	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
742013005079	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
742013005080	succinic semialdehyde dehydrogenase; Region: PLN02278
742013005081	Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103
742013005082	tetramerization interface [polypeptide binding]; other site
742013005083	NAD(P) binding site [chemical binding]; other site
742013005084	catalytic residues [active]
742013005085	4-aminobutyrate aminotransferase; Provisional; Region: PRK06777
742013005086	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
742013005087	inhibitor-cofactor binding pocket; inhibition site
742013005088	pyridoxal 5'-phosphate binding site [chemical binding]; other site
742013005089	catalytic residue [active]
742013005090	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
742013005091	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
742013005092	DNA-binding site [nucleotide binding]; DNA binding site
742013005093	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
742013005094	pyridoxal 5'-phosphate binding site [chemical binding]; other site
742013005095	homodimer interface [polypeptide binding]; other site
742013005096	catalytic residue [active]
742013005097	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
742013005098	CYTH-like Clostridium thermocellum TTM-like subgroup 1; Region: CYTH-like_CthTTM-like_1; cd07891
742013005099	putative active site [active]
742013005100	putative metal binding residues [ion binding]; other site
742013005101	signature motif; other site
742013005102	putative dimer interface [polypeptide binding]; other site
742013005103	putative phosphate binding site [ion binding]; other site
742013005104	RNA polymerase sigma factor RpoD; Validated; Region: PRK05658
742013005105	Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979
742013005106	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
742013005107	Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546
742013005108	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
742013005109	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
742013005110	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
742013005111	DNA binding residues [nucleotide binding]
742013005112	DNA primase, catalytic core; Region: dnaG; TIGR01391
742013005113	CHC2 zinc finger; Region: zf-CHC2; pfam01807
742013005114	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
742013005115	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
742013005116	active site
742013005117	metal binding site [ion binding]; metal-binding site
742013005118	interdomain interaction site; other site
742013005119	DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410
742013005120	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
742013005121	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
742013005122	ATP binding site [chemical binding]; other site
742013005123	Mg2+ binding site [ion binding]; other site
742013005124	G-X-G motif; other site
742013005125	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
742013005126	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
742013005127	active site
742013005128	phosphorylation site [posttranslational modification]
742013005129	intermolecular recognition site; other site
742013005130	dimerization interface [polypeptide binding]; other site
742013005131	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355
742013005132	DNA binding site [nucleotide binding]
742013005133	SPFH domain / Band 7 family; Region: Band_7; pfam01145
742013005134	acyl-CoA synthetase; Validated; Region: PRK08162
742013005135	Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles and Arabidopsis; Region: ttLC_FACS_AEE21_like; cd12118
742013005136	acyl-activating enzyme (AAE) consensus motif; other site
742013005137	putative active site [active]
742013005138	AMP binding site [chemical binding]; other site
742013005139	putative CoA binding site [chemical binding]; other site
742013005140	Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910
742013005141	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
742013005142	active site
742013005143	Protein of unknown function (DUF3423); Region: DUF3423; pfam11903
742013005144	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
742013005145	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
742013005146	Putative catalytic domain, repeat 1, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_1; cd09111
742013005147	putative active site [active]
742013005148	catalytic site [active]
742013005149	Putative catalytic domain, repeat 2, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_2; cd09113
742013005150	PLD-like domain; Region: PLDc_2; pfam13091
742013005151	putative active site [active]
742013005152	catalytic site [active]
742013005153	sodium--glutamate symport carrier (gltS); Region: gltS; TIGR00210
742013005154	PhoD-like phosphatase; Region: PhoD; pfam09423
742013005155	Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389
742013005156	putative active site [active]
742013005157	putative metal binding site [ion binding]; other site
742013005158	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
742013005159	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
742013005160	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
742013005161	metal binding site [ion binding]; metal-binding site
742013005162	active site
742013005163	I-site; other site
742013005164	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
742013005165	Quinone oxidoreductase (QOR); Region: QOR1; cd08241
742013005166	NAD(P) binding site [chemical binding]; other site
742013005167	5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346
742013005168	protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312
742013005169	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
742013005170	S-adenosylmethionine binding site [chemical binding]; other site
742013005171	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
742013005172	Peptidase family M23; Region: Peptidase_M23; pfam01551
742013005173	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
742013005174	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
742013005175	RNA binding surface [nucleotide binding]; other site
742013005176	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
742013005177	active site
742013005178	Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079
742013005179	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
742013005180	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
742013005181	RNA binding surface [nucleotide binding]; other site
742013005182	Pseudouridine synthase, Escherichia coli RluB like; Region: PseudoU_synth_RluB; cd02556
742013005183	probable active site [active]
742013005184	Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413
742013005185	active site
742013005186	multimer interface [polypeptide binding]; other site
742013005187	ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK11194
742013005188	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
742013005189	FeS/SAM binding site; other site
742013005190	type IV pilus biogenesis/stability protein PilW; Region: type_IV_pilW; TIGR02521
742013005191	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
742013005192	binding surface
742013005193	TPR motif; other site
742013005194	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
742013005195	binding surface
742013005196	TPR motif; other site
742013005197	Helix-turn-helix domain; Region: HTH_25; pfam13413
742013005198	Domain of unknown function (DUF4115); Region: DUF4115; pfam13464
742013005199	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366
742013005200	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
742013005201	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
742013005202	histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037
742013005203	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
742013005204	dimer interface [polypeptide binding]; other site
742013005205	motif 1; other site
742013005206	active site
742013005207	motif 2; other site
742013005208	motif 3; other site
742013005209	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
742013005210	anticodon binding site; other site
742013005211	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2976
742013005212	Uncharacterized protein conserved in bacteria (DUF2133); Region: DUF2133; pfam09976
742013005213	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
742013005214	binding surface
742013005215	TPR motif; other site
742013005216	outer membrane assembly lipoprotein YfgL; Region: assembly_YfgL; TIGR03300
742013005217	PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493
742013005218	Trp docking motif [polypeptide binding]; other site
742013005219	active site
742013005220	GTP-binding protein Der; Reviewed; Region: PRK00093
742013005221	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
742013005222	G1 box; other site
742013005223	GTP/Mg2+ binding site [chemical binding]; other site
742013005224	Switch I region; other site
742013005225	G2 box; other site
742013005226	Switch II region; other site
742013005227	G3 box; other site
742013005228	G4 box; other site
742013005229	G5 box; other site
742013005230	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
742013005231	G1 box; other site
742013005232	GTP/Mg2+ binding site [chemical binding]; other site
742013005233	Switch I region; other site
742013005234	G2 box; other site
742013005235	G3 box; other site
742013005236	Switch II region; other site
742013005237	G4 box; other site
742013005238	G5 box; other site
742013005239	bacterial Hfq-like; Region: Hfq; cd01716
742013005240	hexamer interface [polypeptide binding]; other site
742013005241	Sm1 motif; other site
742013005242	RNA binding site [nucleotide binding]; other site
742013005243	Sm2 motif; other site
742013005244	GTP-binding protein HflX; Region: GTP_HflX; TIGR03156
742013005245	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
742013005246	HflX GTPase family; Region: HflX; cd01878
742013005247	G1 box; other site
742013005248	GTP/Mg2+ binding site [chemical binding]; other site
742013005249	Switch I region; other site
742013005250	G2 box; other site
742013005251	G3 box; other site
742013005252	Switch II region; other site
742013005253	G4 box; other site
742013005254	G5 box; other site
742013005255	Bacterial membrane protein N terminal; Region: HflK_N; pfam12221
742013005256	Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404
742013005257	HflK protein; Region: hflK; TIGR01933
742013005258	HflC protein; Region: hflC; TIGR01932
742013005259	Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405
742013005260	ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: PRK12421
742013005261	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
742013005262	dimer interface [polypeptide binding]; other site
742013005263	motif 1; other site
742013005264	active site
742013005265	motif 2; other site
742013005266	motif 3; other site
742013005267	adenylosuccinate synthetase; Provisional; Region: PRK01117
742013005268	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
742013005269	Predicted phosphoribosyltransferases [General function prediction only]; Region: COG2236
742013005270	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
742013005271	active site
742013005272	Uncharacterized conserved protein [Function unknown]; Region: COG3391
742013005273	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
742013005274	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
742013005275	Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917
742013005276	NodB motif; other site
742013005277	active site
742013005278	catalytic site [active]
742013005279	metal binding site [ion binding]; metal-binding site
742013005280	Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000
742013005281	Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116
742013005282	Etoposide-induced protein 2.4 (EI24); Region: EI24; pfam07264
742013005283	Predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA [General function prediction only]; Region: CinA; COG1058
742013005284	Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885
742013005285	putative MPT binding site; other site
742013005286	glutamine synthetase; Provisional; Region: glnA; PRK09469
742013005287	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
742013005288	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
742013005289	SH3 domain protein; Region: SH3_and_anchor; TIGR04211
742013005290	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
742013005291	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
742013005292	putative active site [active]
742013005293	heme pocket [chemical binding]; other site
742013005294	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
742013005295	dimer interface [polypeptide binding]; other site
742013005296	phosphorylation site [posttranslational modification]
742013005297	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
742013005298	ATP binding site [chemical binding]; other site
742013005299	Mg2+ binding site [ion binding]; other site
742013005300	G-X-G motif; other site
742013005301	nitrogen regulation protein NR(I); Region: ntrC; TIGR01818
742013005302	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
742013005303	active site
742013005304	phosphorylation site [posttranslational modification]
742013005305	intermolecular recognition site; other site
742013005306	dimerization interface [polypeptide binding]; other site
742013005307	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
742013005308	Walker A motif; other site
742013005309	ATP binding site [chemical binding]; other site
742013005310	Walker B motif; other site
742013005311	arginine finger; other site
742013005312	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
742013005313	Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086
742013005314	putative catalytic site [active]
742013005315	putative phosphate binding site [ion binding]; other site
742013005316	active site
742013005317	metal binding site A [ion binding]; metal-binding site
742013005318	DNA binding site [nucleotide binding]
742013005319	putative AP binding site [nucleotide binding]; other site
742013005320	putative metal binding site B [ion binding]; other site
742013005321	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
742013005322	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
742013005323	NAD(P) binding site [chemical binding]; other site
742013005324	catalytic residues [active]
742013005325	MarR family; Region: MarR_2; cl17246
742013005326	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
742013005327	Transcriptional regulators [Transcription]; Region: PurR; COG1609
742013005328	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
742013005329	DNA binding site [nucleotide binding]
742013005330	domain linker motif; other site
742013005331	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
742013005332	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
742013005333	Uncharacterized protein involved in propionate catabolism [General function prediction only]; Region: PrpD; COG2079
742013005334	FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2  has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451
742013005335	putative active site [active]
742013005336	putative catalytic site [active]
742013005337	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
742013005338	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
742013005339	active site
742013005340	FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2  has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451
742013005341	putative active site [active]
742013005342	putative catalytic site [active]
742013005343	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
742013005344	CoA-transferase family III; Region: CoA_transf_3; pfam02515
742013005345	Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301
742013005346	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
742013005347	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
742013005348	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
742013005349	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
742013005350	TM-ABC transporter signature motif; other site
742013005351	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
742013005352	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
742013005353	TM-ABC transporter signature motif; other site
742013005354	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
742013005355	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
742013005356	Walker A/P-loop; other site
742013005357	ATP binding site [chemical binding]; other site
742013005358	Q-loop/lid; other site
742013005359	ABC transporter signature motif; other site
742013005360	Walker B; other site
742013005361	D-loop; other site
742013005362	H-loop/switch region; other site
742013005363	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
742013005364	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
742013005365	Walker A/P-loop; other site
742013005366	ATP binding site [chemical binding]; other site
742013005367	Q-loop/lid; other site
742013005368	ABC transporter signature motif; other site
742013005369	Walker B; other site
742013005370	D-loop; other site
742013005371	H-loop/switch region; other site
742013005372	MmgE/PrpD family; Region: MmgE_PrpD; cl00912
742013005373	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231
742013005374	classical (c) SDRs; Region: SDR_c; cd05233
742013005375	NAD(P) binding site [chemical binding]; other site
742013005376	active site
742013005377	putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824
742013005378	PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276
742013005379	NAD(P) binding site [chemical binding]; other site
742013005380	Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618
742013005381	Amidohydrolase; Region: Amidohydro_2; pfam04909
742013005382	Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301
742013005383	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
742013005384	Major Facilitator Superfamily; Region: MFS_1; pfam07690
742013005385	putative substrate translocation pore; other site
742013005386	Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049
742013005387	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
742013005388	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
742013005389	dimer interface [polypeptide binding]; other site
742013005390	putative CheW interface [polypeptide binding]; other site
742013005391	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
742013005392	p-hydroxycinnamoyl CoA hydratase/lyase; Validated; Region: PRK09120
742013005393	substrate binding site [chemical binding]; other site
742013005394	oxyanion hole (OAH) forming residues; other site
742013005395	trimer interface [polypeptide binding]; other site
742013005396	Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618
742013005397	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cd01292
742013005398	active site
742013005399	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
742013005400	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
742013005401	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
742013005402	acyl-activating enzyme (AAE) consensus motif; other site
742013005403	AMP binding site [chemical binding]; other site
742013005404	active site
742013005405	CoA binding site [chemical binding]; other site
742013005406	hypothetical protein; Provisional; Region: PRK07475
742013005407	Transcriptional regulator [Transcription]; Region: LysR; COG0583
742013005408	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
742013005409	Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent  decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919
742013005410	tetramerization interface [polypeptide binding]; other site
742013005411	active site
742013005412	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
742013005413	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
742013005414	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
742013005415	trimer interface [polypeptide binding]; other site
742013005416	eyelet of channel; other site
742013005417	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
742013005418	Transcriptional regulator [Transcription]; Region: IclR; COG1414
742013005419	IclR helix-turn-helix domain; Region: HTH_IclR; cl17605
742013005420	Bacterial transcriptional regulator; Region: IclR; pfam01614
742013005421	Hemerythrin; Region: Hemerythrin; cd12107
742013005422	Fe binding site [ion binding]; other site
742013005423	Rieske non-heme iron oxygenase (RO) family, Phthalate 4,5-dioxygenase (PhDO)-like subfamily, N-terminal Rieske domain of the oxygenase alpha subunit; composed of the oxygenase alpha subunits of PhDO and similar proteins including 3-chlorobenzoate 3; Region: Rieske_RO_Alpha_PhDO_like; cd03479
742013005424	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
742013005425	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
742013005426	hydrophobic ligand binding site; other site
742013005427	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432
742013005428	nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK06978
742013005429	Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572
742013005430	dimerization interface [polypeptide binding]; other site
742013005431	active site
742013005432	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
742013005433	Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal  ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185
742013005434	FMN-binding pocket [chemical binding]; other site
742013005435	flavin binding motif; other site
742013005436	phosphate binding motif [ion binding]; other site
742013005437	beta-alpha-beta structure motif; other site
742013005438	NAD binding pocket [chemical binding]; other site
742013005439	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
742013005440	catalytic loop [active]
742013005441	iron binding site [ion binding]; other site
742013005442	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
742013005443	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
742013005444	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
742013005445	Rieske non-heme iron oxygenase (RO) family, Phthalate 4,5-dioxygenase (PhDO)-like subfamily, N-terminal Rieske domain of the oxygenase alpha subunit; composed of the oxygenase alpha subunits of PhDO and similar proteins including 3-chlorobenzoate 3; Region: Rieske_RO_Alpha_PhDO_like; cd03479
742013005446	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
742013005447	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
742013005448	hydrophobic ligand binding site; other site
742013005449	Protein of unknown function (DUF2798); Region: DUF2798; pfam11391
742013005450	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
742013005451	Integrase core domain; Region: rve; pfam00665
742013005452	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
742013005453	Walker A motif; other site
742013005454	ATP binding site [chemical binding]; other site
742013005455	Walker B motif; other site
742013005456	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
742013005457	Amidohydrolase; Region: Amidohydro_2; pfam04909
742013005458	hypothetical protein; Provisional; Region: PRK09262
742013005459	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
742013005460	D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain; Region: 2-Hacid_dh_C; pfam02826
742013005461	Domain of unknown function (DUF1932); Region: DUF1932; pfam09130
742013005462	Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618
742013005463	2-pyrone-4,6-dicarboxylic acid (PDC) hydrolase hydrolyzes PDC to yield 4-oxalomesaconic acid (OMA) or its tautomer, 4-carboxy-2-hydroxymuconic acid (CHM). This reaction is part of the protocatechuate (PCA) 4,5-cleavage pathway. PCA is one of the most...; Region: PDC_hydrolase; cd01311
742013005464	active site
742013005465	The A subunit of Protocatechuate 4,5-dioxygenase (LigAB) is the smaller, non-catalytic subunit; Region: PCA_45_Doxase_A; cd07924
742013005466	tetramer interface [polypeptide binding]; other site
742013005467	dimer interface [polypeptide binding]; other site
742013005468	active site
742013005469	Subunit B of the Class III extradiol dioxygenase, Protocatechuate 4,5-dioxygenase, which catalyzes the oxidization and subsequent ring-opening of protocatechuate; Region: PCA_45_Dioxygenase_B; cd07364
742013005470	Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900
742013005471	active site
742013005472	Fe(II) binding site [ion binding]; other site
742013005473	dimer interface [polypeptide binding]; other site
742013005474	tetramer interface [polypeptide binding]; other site
742013005475	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
742013005476	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
742013005477	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
742013005478	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
742013005479	active site
742013005480	catalytic tetrad [active]
742013005481	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
742013005482	The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112
742013005483	P-loop, Walker A motif; other site
742013005484	Base recognition motif; other site
742013005485	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683
742013005486	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
742013005487	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
742013005488	TraG-like protein, N-terminal region; Region: TraG_N; pfam07916
742013005489	Conjugative relaxosome accessory transposon protein; Region: TraH; pfam06122
742013005490	conjugal transfer protein TrbB; Provisional; Region: PRK13728; cl17283
742013005491	F plasmid transfer operon protein; Region: TraF; pfam13728
742013005492	conjugal transfer mating pair stabilization protein TraN; Reviewed; Region: PRK12355
742013005493	conjugal transfer mating pair stabilization protein TraN; Reviewed; Region: PRK12355
742013005494	Type-F conjugative transfer system pilin assembly protein; Region: TrbC_Ftype; pfam09673
742013005495	TraU protein; Region: TraU; pfam06834
742013005496	Sex factor F TraW protein N terminal; Region: TraW_N; cl10149
742013005497	conjugative transfer signal peptidase TraF; Region: TraF_Ti; TIGR02771
742013005498	conjugal transfer pilin processing protease TraF; Provisional; Region: PRK13838
742013005499	F pilus assembly Type-IV secretion system for plasmid transfer; Region: TraC_F_IV; pfam11130
742013005500	type-IV secretion system protein TraC; Region: TraC-F-type; TIGR02746
742013005501	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
742013005502	Walker A motif; other site
742013005503	ATP binding site [chemical binding]; other site
742013005504	Type IV conjugative transfer system lipoprotein (TraV); Region: TraV; pfam09676
742013005505	DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020
742013005506	dimerization domain [polypeptide binding]; other site
742013005507	dimer interface [polypeptide binding]; other site
742013005508	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
742013005509	catalytic residues [active]
742013005510	Bacterial conjugation TrbI-like protein; Region: TrbI; pfam03743
742013005511	TraK protein; Region: TraK; pfam06586
742013005512	conjugal transfer protein TraK; Provisional; Region: PRK13736; cl05878
742013005513	TraE protein; Region: TraE; cl05060
742013005514	TraL protein; Region: TraL; pfam07178
742013005515	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
742013005516	ligand binding site [chemical binding]; other site
742013005517	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
742013005518	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
742013005519	N-acetyl-D-glucosamine binding site [chemical binding]; other site
742013005520	catalytic residue [active]
742013005521	H-NS histone family; Region: Histone_HNS; pfam00816
742013005522	Domain in histone-like proteins of HNS family; Region: HNS; smart00528
742013005523	Domain of unknown function (DUF4400); Region: DUF4400; cl14023
742013005524	conjugative coupling factor TraD, SXT/TOL subfamily; Region: SXT_TraD; TIGR03743
742013005525	TraM recognition site of TraD and TraG; Region: TraG-D_C; cl17375
742013005526	Putative helicase; Region: TraI_2; pfam07514
742013005527	integrating conjugative element relaxase, PFL_4751 family; Region: ICE_TraI_Pfluor; TIGR03760
742013005528	Flagellar transcriptional activator (FlhC); Region: FlhC; cl05036
742013005529	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
742013005530	Predicted transcriptional regulator [Transcription]; Region: COG2932
742013005531	Catalytic site [active]
742013005532	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4643
742013005533	Zinc-binding domain of primase-helicase; Region: Prim_Zn_Ribbon; smart00778
742013005534	Toprim domain; Region: Toprim_3; pfam13362
742013005535	Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; cl17523
742013005536	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
742013005537	homodimer interface [polypeptide binding]; other site
742013005538	putative active site [active]
742013005539	Fic/DOC family; Region: Fic; pfam02661
742013005540	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
742013005541	active site
742013005542	catalytic residues [active]
742013005543	Int/Topo IB signature motif; other site
742013005544	DNA binding site [nucleotide binding]
742013005545	Citrate synthase [Energy production and conversion]; Region: GltA; COG0372
742013005546	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
742013005547	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
742013005548	non-specific DNA binding site [nucleotide binding]; other site
742013005549	salt bridge; other site
742013005550	sequence-specific DNA binding site [nucleotide binding]; other site
742013005551	Transcriptional regulator [Transcription]; Region: LysR; COG0583
742013005552	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
742013005553	The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433
742013005554	putative dimerization interface [polypeptide binding]; other site
742013005555	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
742013005556	Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042
742013005557	CoA binding domain; Region: CoA_binding_2; pfam13380
742013005558	Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607
742013005559	ATP-grasp domain; Region: ATP-grasp_5; pfam13549
742013005560	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
742013005561	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
742013005562	substrate binding site [chemical binding]; other site
742013005563	oxyanion hole (OAH) forming residues; other site
742013005564	trimer interface [polypeptide binding]; other site
742013005565	Protein of unknown function (DUF1173); Region: DUF1173; pfam06666
742013005566	Autoinducer binding domain; Region: Autoind_bind; pfam03472
742013005567	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
742013005568	DNA binding residues [nucleotide binding]
742013005569	dimerization interface [polypeptide binding]; other site
742013005570	Autoinducer synthetase; Region: Autoind_synth; cl17404
742013005571	Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007
742013005572	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
742013005573	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005
742013005574	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
742013005575	IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817
742013005576	Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528
742013005577	[2Fe-2S] cluster binding site [ion binding]; other site
742013005578	CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated; Region: PRK07609
742013005579	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
742013005580	catalytic loop [active]
742013005581	iron binding site [ion binding]; other site
742013005582	Toluene-4-monoxygenase electron transfer component of Pseudomonas mendocina hydroxylates toluene and forms p-cresol as part of a three component toluene-4-monoxygenase system. Electron transfer is from NADH to an NADH:ferredoxin oxidoreductase (TmoF in P; Region: T4MO_e_transfer_like; cd06190
742013005583	FAD binding pocket [chemical binding]; other site
742013005584	FAD binding motif [chemical binding]; other site
742013005585	phosphate binding motif [ion binding]; other site
742013005586	beta-alpha-beta structure motif; other site
742013005587	NAD binding pocket [chemical binding]; other site
742013005588	2,3-dihydroxy-2,3-dihydrophenylpropionate dehydrogenase; Provisional; Region: PRK06200
742013005589	cis-biphenyl-2,3-dihydrodiol-2,3-dehydrogenase (BphB)-like, classical (c) SDRs; Region: BphB-like_SDR_c; cd05348
742013005590	NAD binding site [chemical binding]; other site
742013005591	active site
742013005592	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
742013005593	iron-sulfur cluster [ion binding]; other site
742013005594	[2Fe-2S] cluster binding site [ion binding]; other site
742013005595	C-terminal catalytic domain of the oxygenase alpha subunit of naphthalene 1,2-dioxygenase (NDO) and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_NDO-like; cd08881
742013005596	beta subunit interface [polypeptide binding]; other site
742013005597	alpha subunit interface [polypeptide binding]; other site
742013005598	active site
742013005599	substrate binding site [chemical binding]; other site
742013005600	Fe binding site [ion binding]; other site
742013005601	Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667
742013005602	inter-subunit interface; other site
742013005603	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
742013005604	DsbA family, 2-hydroxychromene-2-carboxylate (HCCA) isomerase subfamily; HCCA isomerase is a glutathione (GSH) dependent enzyme involved in the naphthalene catabolic pathway. It converts HCCA, a hemiketal formed spontaneously after ring cleavage of 1; Region: DsbA_HCCA_Iso; cd03022
742013005605	putative catalytic residue [active]
742013005606	Transposase domain (DUF772); Region: DUF772; pfam05598
742013005607	Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039
742013005608	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
742013005609	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
742013005610	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
742013005611	glutathionine S-transferase; Provisional; Region: PRK10542
742013005612	GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057
742013005613	C-terminal domain interface [polypeptide binding]; other site
742013005614	GSH binding site (G-site) [chemical binding]; other site
742013005615	dimer interface [polypeptide binding]; other site
742013005616	C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188
742013005617	dimer interface [polypeptide binding]; other site
742013005618	N-terminal domain interface [polypeptide binding]; other site
742013005619	substrate binding pocket (H-site) [chemical binding]; other site
742013005620	Class I aldolases; Region: Aldolase_Class_I; cl17187
742013005621	catalytic residue [active]
742013005622	Gentisate 1,2-dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3435
742013005623	Cupin domain; Region: Cupin_2; pfam07883
742013005624	Transposase domain (DUF772); Region: DUF772; pfam05598
742013005625	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
742013005626	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
742013005627	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
742013005628	MarR family; Region: MarR_2; pfam12802
742013005629	2,3-dihydroxybiphenyl 1,2-dioxygenase; Region: 23dbph12diox; TIGR03213
742013005630	N-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_N_like; cd07252
742013005631	C-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_C_like; cd07237
742013005632	active site
742013005633	Fe binding site [ion binding]; other site
742013005634	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
742013005635	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
742013005636	NAD(P) binding site [chemical binding]; other site
742013005637	catalytic residues [active]
742013005638	Protein of unknown function (DUF1302); Region: DUF1302; pfam06980
742013005639	Protein of unknown function (DUF1329); Region: DUF1329; pfam07044
742013005640	Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447
742013005641	Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033
742013005642	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
742013005643	Trans-o-hydroxybenzylidenepyruvate hydratase-aldolase (HBPHA) and trans-2'-carboxybenzalpyruvate hydratase-aldolase (CBPHA); Region: CHBPH_aldolase; cd00952
742013005644	putative active site [active]
742013005645	catalytic residue [active]
742013005646	Transposase domain (DUF772); Region: DUF772; pfam05598
742013005647	Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039
742013005648	Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612
742013005649	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
742013005650	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
742013005651	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005
742013005652	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
742013005653	Helix-turn-helix domain; Region: HTH_28; pfam13518
742013005654	putative transposase OrfB; Reviewed; Region: PHA02517
742013005655	HTH-like domain; Region: HTH_21; pfam13276
742013005656	Integrase core domain; Region: rve; pfam00665
742013005657	Integrase core domain; Region: rve_2; pfam13333
742013005658	DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484
742013005659	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
742013005660	Walker A motif; other site
742013005661	ATP binding site [chemical binding]; other site
742013005662	Walker B motif; other site
742013005663	Isochorismatase family; Region: Isochorismatase; pfam00857
742013005664	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220
742013005665	catalytic triad [active]
742013005666	conserved cis-peptide bond; other site
742013005667	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
742013005668	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
742013005669	NAD(P) binding site [chemical binding]; other site
742013005670	catalytic residues [active]
742013005671	ATP-dependent DNA helicase DinG; Provisional; Region: dinG; PRK11747
742013005672	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
742013005673	DEAD_2; Region: DEAD_2; pfam06733
742013005674	Helicase C-terminal domain; Region: Helicase_C_2; pfam13307
742013005675	Transcriptional regulator [Transcription]; Region: LysR; COG0583
742013005676	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
742013005677	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
742013005678	putative effector binding pocket; other site
742013005679	dimerization interface [polypeptide binding]; other site
742013005680	Fic/DOC family; Region: Fic; pfam02661
742013005681	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
742013005682	Helix-turn-helix domain; Region: HTH_18; pfam12833
742013005683	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
742013005684	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
742013005685	Major Facilitator Superfamily; Region: MFS_1; pfam07690
742013005686	putative substrate translocation pore; other site
742013005687	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181
742013005688	Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286
742013005689	Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which  binds to Adenosine nucleotide; Region: AANH_like; cl00292
742013005690	Ligand Binding Site [chemical binding]; other site
742013005691	Nucleotidyltransferase (NT) domain of 2'5'-oligoadenylate (2-5A)synthetase (2-5OAS) and class I CCA-adding enzyme; Region: NT_2-5OAS_ClassI-CCAase; cd05400
742013005692	active site
742013005693	NTP binding site [chemical binding]; other site
742013005694	metal binding triad [ion binding]; metal-binding site
742013005695	Nucleotidyltransferase (NT) domain of 2'5'-oligoadenylate (2-5A)synthetase (2-5OAS) and class I CCA-adding enzyme; Region: NT_2-5OAS_ClassI-CCAase; cd05400
742013005696	active site
742013005697	NTP binding site [chemical binding]; other site
742013005698	metal binding triad [ion binding]; metal-binding site
742013005699	Domain of unknown function (DUF955); Region: DUF955; pfam06114
742013005700	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4688
742013005701	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
742013005702	DNA binding site [nucleotide binding]
742013005703	Int/Topo IB signature motif; other site
742013005704	active site
742013005705	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cl00257
742013005706	IHF dimer interface [polypeptide binding]; other site
742013005707	IHF - DNA interface [nucleotide binding]; other site
742013005708	ParB-like nuclease domain; Region: ParB; smart00470
742013005709	PRTRC system ParB family protein; Region: PRTRC_parB; TIGR03734
742013005710	PRTRC system protein E; Region: PRTRC_E; TIGR03741
742013005711	PRTRC system protein C; Region: PRTRC_C; TIGR03738
742013005712	PRTRC system protein F; Region: PRTRC_F; TIGR03742
742013005713	Alpha-helical domain 2; Region: alpha-hel2; pfam14456
742013005714	Prokaryotic E2 family D; Region: Prok-E2_D; cl14019
742013005715	Domain of unknown function (DUF2016); Region: DUF2016; pfam09436
742013005716	PRTRC system protein A; Region: PRTRC_A; TIGR03735
742013005717	Prokaryotic homologs of the JAB domain; Region: Prok-JAB; pfam14464
742013005718	PRTRC system ThiF family protein; Region: PRTRC_ThiF; TIGR03736
742013005719	Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cd01483
742013005720	ATP binding site [chemical binding]; other site
742013005721	substrate interface [chemical binding]; other site
742013005722	ParB-like nuclease domain; Region: ParBc; pfam02195
742013005723	Phage integrase, N-terminal; Region: Integrase_l_N; pfam12834
742013005724	Integrase; Region: Integrase_1; pfam12835
742013005725	SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195
742013005726	SIR2-like domain; Region: SIR2_2; pfam13289
742013005727	Transposase, Mutator family; Region: Transposase_mut; pfam00872
742013005728	MULE transposase domain; Region: MULE; pfam10551
742013005729	Transposase; Region: DEDD_Tnp_IS110; pfam01548
742013005730	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
742013005731	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
742013005732	PRTRC system protein D; Region: PRTRC_D; TIGR03739
742013005733	Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227
742013005734	Mg binding site [ion binding]; other site
742013005735	nucleotide binding site [chemical binding]; other site
742013005736	putative protofilament interface [polypeptide binding]; other site
742013005737	PRTRC system protein D; Region: PRTRC_D; TIGR03739
742013005738	Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227
742013005739	Mg binding site [ion binding]; other site
742013005740	nucleotide binding site [chemical binding]; other site
742013005741	putative protofilament interface [polypeptide binding]; other site
742013005742	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
742013005743	Walker A motif; other site
742013005744	ATP binding site [chemical binding]; other site
742013005745	Walker B motif; other site
742013005746	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
742013005747	Integrase core domain; Region: rve; pfam00665
742013005748	Part of AAA domain; Region: AAA_19; pfam13245
742013005749	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
742013005750	Family description; Region: UvrD_C_2; pfam13538
742013005751	Predicted ATP-dependent endonuclease of the OLD family [DNA replication, recombination, and repair]; Region: COG3593
742013005752	Protein of unknown function (DUF2813); Region: DUF2813; pfam11398
742013005753	TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family.  The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026
742013005754	putative active site [active]
742013005755	putative metal-binding site [ion binding]; other site
742013005756	integrase; Provisional; Region: PRK09692
742013005757	Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements.  They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801
742013005758	active site
742013005759	Int/Topo IB signature motif; other site
742013005760	Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020
742013005761	active site
742013005762	Peptidase family M50; Region: Peptidase_M50; pfam02163
742013005763	putative substrate binding region [chemical binding]; other site
742013005764	P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539
742013005765	cytosine deaminase; Validated; Region: PRK07572
742013005766	Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293
742013005767	active site
742013005768	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
742013005769	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
742013005770	ligand binding site [chemical binding]; other site
742013005771	flexible hinge region; other site
742013005772	DNA-binding transcriptional regulator LysR; Provisional; Region: PRK11013
742013005773	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
742013005774	The C-terminal substrate-domain of LysR-type transcriptional regulators involved in the catabolism of opines and that of related regulators, contains the type 2 periplasmic binding fold; Region: PBP2_LysR_opines_like; cd08415
742013005775	putative dimerization interface [polypeptide binding]; other site
742013005776	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
742013005777	Bacterial Ig-like domain (group 1); Region: Big_1; cl17740
742013005778	Microcystin-dependent protein [Function unknown]; Region: MdpB; COG4675
742013005779	Phage Tail Collar Domain; Region: Collar; pfam07484
742013005780	Microcystin-dependent protein [Function unknown]; Region: MdpB; COG4675
742013005781	Phage Tail Collar Domain; Region: Collar; pfam07484
742013005782	Microcystin-dependent protein [Function unknown]; Region: MdpB; COG4675
742013005783	Phage Tail Collar Domain; Region: Collar; pfam07484
742013005784	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
742013005785	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
742013005786	Coenzyme A binding pocket [chemical binding]; other site
742013005787	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
742013005788	Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813
742013005789	PA_subtilisin_1: Protease-associated domain containing subtilisin-like proteases, subgroup 1. A subgroup of PA domain-containing subtilisin-like proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined; Region: PA_subtilisin_1; cd04818
742013005790	PA/protease or protease-like domain interface [polypeptide binding]; other site
742013005791	Peptidase M36 family also known as fungalysin family; Region: M36; cd09596
742013005792	Zn binding site [ion binding]; other site
742013005793	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
742013005794	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
742013005795	inhibitor site; inhibition site
742013005796	active site
742013005797	dimer interface [polypeptide binding]; other site
742013005798	catalytic residue [active]
742013005799	L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948
742013005800	Mandelate racemase (MR)-like subfamily of the enolase superfamily, subgroup 2. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic...; Region: MR_like_2; cd03327
742013005801	putative active site pocket [active]
742013005802	putative metal binding site [ion binding]; other site
742013005803	4-hydroxythreonine-4-phosphate dehydrogenase; Reviewed; Region: pdxA; PRK00232
742013005804	4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743
742013005805	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
742013005806	pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424
742013005807	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
742013005808	The C-terminal substrate binding domain of galactose-binding protein regulator contains the type 2 periplasmic binding fold; Region: PBP2_GbpR; cd08435
742013005809	putative dimerization interface [polypeptide binding]; other site
742013005810	Transcriptional regulator [Transcription]; Region: LysR; COG0583
742013005811	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
742013005812	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
742013005813	dimerization interface [polypeptide binding]; other site
742013005814	hypothetical protein; Provisional; Region: PRK05463
742013005815	5-oxoprolinase; Region: PLN02666
742013005816	Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378
742013005817	Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968
742013005818	N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146
742013005819	benzoate transport; Region: 2A0115; TIGR00895
742013005820	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
742013005821	putative substrate translocation pore; other site
742013005822	Domain of unknown function (DUF1993); Region: DUF1993; pfam09351
742013005823	Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637
742013005824	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
742013005825	motif II; other site
742013005826	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
742013005827	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
742013005828	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
742013005829	DNA binding residues [nucleotide binding]
742013005830	Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712
742013005831	FecR protein; Region: FecR; pfam04773
742013005832	Secretin and TonB N terminus short domain; Region: STN; smart00965
742013005833	Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion transport and metabolism]; Region: FhuE; COG4773
742013005834	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
742013005835	N-terminal plug; other site
742013005836	ligand-binding site [chemical binding]; other site
742013005837	RNA polymerase sigma factor; Provisional; Region: PRK12528
742013005838	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
742013005839	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
742013005840	DNA binding residues [nucleotide binding]
742013005841	fec operon regulator FecR; Reviewed; Region: PRK09774
742013005842	FecR protein; Region: FecR; pfam04773
742013005843	Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion transport and metabolism]; Region: FhuE; COG4773
742013005844	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
742013005845	N-terminal plug; other site
742013005846	ligand-binding site [chemical binding]; other site
742013005847	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
742013005848	active site
742013005849	metal binding site [ion binding]; metal-binding site
742013005850	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
742013005851	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
742013005852	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209
742013005853	folate binding site [chemical binding]; other site
742013005854	NADP+ binding site [chemical binding]; other site
742013005855	thymidylate synthase; Reviewed; Region: thyA; PRK01827
742013005856	Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351
742013005857	dimerization interface [polypeptide binding]; other site
742013005858	active site
742013005859	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
742013005860	FAD binding domain; Region: FAD_binding_4; pfam01565
742013005861	Predicted membrane protein (DUF2069); Region: DUF2069; pfam09842
742013005862	Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918
742013005863	Protein of unknown function (DUF962); Region: DUF962; pfam06127
742013005864	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
742013005865	Choline/Carnitine o-acyltransferase; Region: Carn_acyltransf; pfam00755
742013005866	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
742013005867	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
742013005868	Predicted acetamidase/formamidase [Energy production and conversion]; Region: COG2421
742013005869	Predicted acetamidase/formamidase [Energy production and conversion]; Region: COG2421
742013005870	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
742013005871	Lipase.  Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883
742013005872	nucleophilic elbow; other site
742013005873	catalytic triad; other site
742013005874	O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK08134
742013005875	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
742013005876	homodimer interface [polypeptide binding]; other site
742013005877	substrate-cofactor binding pocket; other site
742013005878	pyridoxal 5'-phosphate binding site [chemical binding]; other site
742013005879	catalytic residue [active]
742013005880	FOG: CBS domain [General function prediction only]; Region: COG0517
742013005881	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
742013005882	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
742013005883	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
742013005884	Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082
742013005885	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
742013005886	Tetramer interface [polypeptide binding]; other site
742013005887	active site
742013005888	FMN-binding site [chemical binding]; other site
742013005889	transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464
742013005890	ATP cone domain; Region: ATP-cone; pfam03477
742013005891	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
742013005892	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
742013005893	dimer interface [polypeptide binding]; other site
742013005894	active site
742013005895	glycine-pyridoxal phosphate binding site [chemical binding]; other site
742013005896	folate binding site [chemical binding]; other site
742013005897	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
742013005898	N-acetyl-D-glucosamine binding site [chemical binding]; other site
742013005899	catalytic residue [active]
742013005900	Domain of Unknown Function (DUF748); Region: DUF748; pfam05359
742013005901	Domain of Unknown Function (DUF748); Region: DUF748; pfam05359
742013005902	Domain of Unknown Function (DUF748); Region: DUF748; pfam05359
742013005903	Domain of Unknown Function (DUF748); Region: DUF748; pfam05359
742013005904	Domain of Unknown Function (DUF349); Region: DUF349; pfam03993
742013005905	ribonuclease R; Region: RNase_R; TIGR02063
742013005906	Ribonuclease B OB domain; Region: OB_RNB; pfam08206
742013005907	RNB domain; Region: RNB; pfam00773
742013005908	S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471
742013005909	RNA binding site [nucleotide binding]; other site
742013005910	putative carbohydrate kinase; Provisional; Region: PRK10565
742013005911	YjeF-related protein N-terminus; Region: YjeF_N; pfam03853
742013005912	B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171
742013005913	putative substrate binding site [chemical binding]; other site
742013005914	putative ATP binding site [chemical binding]; other site
742013005915	D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711
742013005916	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
742013005917	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
742013005918	rRNA interaction site [nucleotide binding]; other site
742013005919	S8 interaction site; other site
742013005920	putative laminin-1 binding site; other site
742013005921	elongation factor Ts; Provisional; Region: tsf; PRK09377
742013005922	Ubiquitin Associated domain. The UBA domain is a commonly occurring sequence motif in some members of the ubiquitination pathway, UV excision repair proteins, and certain protein kinases. Although its specific role is so far unknown, it has been...; Region: UBA; cl00153
742013005923	Elongation factor TS; Region: EF_TS; pfam00889
742013005924	Elongation factor TS; Region: EF_TS; pfam00889
742013005925	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
742013005926	putative nucleotide binding site [chemical binding]; other site
742013005927	uridine monophosphate binding site [chemical binding]; other site
742013005928	homohexameric interface [polypeptide binding]; other site
742013005929	ribosome recycling factor; Reviewed; Region: frr; PRK00083
742013005930	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520
742013005931	hinge region; other site
742013005932	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230
742013005933	Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255
742013005934	catalytic residue [active]
742013005935	putative FPP diphosphate  binding site; other site
742013005936	putative FPP binding hydrophobic cleft; other site
742013005937	dimer interface [polypeptide binding]; other site
742013005938	putative IPP diphosphate binding site; other site
742013005939	CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575
742013005940	CDP-diglyceride synthase; Provisional; Region: cdsA; PRK11624
742013005941	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447
742013005942	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670
742013005943	1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436
742013005944	DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288
742013005945	zinc metallopeptidase RseP; Provisional; Region: PRK10779
742013005946	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
742013005947	active site
742013005948	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
742013005949	Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020
742013005950	putative substrate binding region [chemical binding]; other site
742013005951	outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303
742013005952	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
742013005953	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
742013005954	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
742013005955	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
742013005956	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
742013005957	Surface antigen; Region: Bac_surface_Ag; pfam01103
742013005958	periplasmic chaperone; Provisional; Region: PRK10780
742013005959	Outer membrane protein (OmpH-like); Region: OmpH; smart00935
742013005960	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892
742013005961	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613
742013005962	UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352
742013005963	trimer interface [polypeptide binding]; other site
742013005964	active site
742013005965	UDP-GlcNAc binding site [chemical binding]; other site
742013005966	lipid binding site [chemical binding]; lipid-binding site
742013005967	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
742013005968	UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289
742013005969	UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351
742013005970	active site
742013005971	lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025
742013005972	ipid-A-disaccharide synthase; Provisional; Region: PRK14089
742013005973	bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
742013005974	RNA/DNA hybrid binding site [nucleotide binding]; other site
742013005975	active site
742013005976	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
742013005977	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
742013005978	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
742013005979	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097
742013005980	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
742013005981	catalytic site [active]
742013005982	subunit interface [polypeptide binding]; other site
742013005983	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
742013005984	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
742013005985	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
742013005986	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cl16941
742013005987	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
742013005988	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
742013005989	ATP-grasp domain; Region: ATP-grasp_4; cl17255
742013005990	Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424
742013005991	IMP binding site; other site
742013005992	dimer interface [polypeptide binding]; other site
742013005993	interdomain contacts; other site
742013005994	partial ornithine binding site; other site
742013005995	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
742013005996	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
742013005997	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
742013005998	Domain of unknown function (DUF4149); Region: DUF4149; pfam13664
742013005999	Escherichia coli YhbY is associated with pre-50S ribosomal subunits, which implies a function in ribosome assembly; Region: CRS1_YhbY; smart01103
742013006000	23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293
742013006001	FtsJ-like methyltransferase; Region: FtsJ; cl17430
742013006002	FtsH Extracellular; Region: FtsH_ext; pfam06480
742013006003	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
742013006004	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
742013006005	Walker A motif; other site
742013006006	ATP binding site [chemical binding]; other site
742013006007	Walker B motif; other site
742013006008	arginine finger; other site
742013006009	Peptidase family M41; Region: Peptidase_M41; pfam01434
742013006010	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
742013006011	dihydropteroate synthase; Region: DHPS; TIGR01496
742013006012	substrate binding pocket [chemical binding]; other site
742013006013	dimer interface [polypeptide binding]; other site
742013006014	inhibitor binding site; inhibition site
742013006015	phosphoglucosamine mutase; Provisional; Region: glmM; PRK10887
742013006016	GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802
742013006017	active site
742013006018	substrate binding site [chemical binding]; other site
742013006019	metal binding site [ion binding]; metal-binding site
742013006020	PAS domain S-box; Region: sensory_box; TIGR00229
742013006021	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
742013006022	putative active site [active]
742013006023	heme pocket [chemical binding]; other site
742013006024	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
742013006025	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
742013006026	metal binding site [ion binding]; metal-binding site
742013006027	active site
742013006028	I-site; other site
742013006029	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
742013006030	exopolyphosphatase; Region: exo_poly_only; TIGR03706
742013006031	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
742013006032	polyphosphate kinase; Provisional; Region: PRK05443
742013006033	Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089
742013006034	Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503
742013006035	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
742013006036	putative active site [active]
742013006037	catalytic site [active]
742013006038	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
742013006039	putative active site [active]
742013006040	catalytic site [active]
742013006041	Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248
742013006042	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
742013006043	PBP superfamily domain; Region: PBP_like_2; cl17296
742013006044	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
742013006045	dimer interface [polypeptide binding]; other site
742013006046	conserved gate region; other site
742013006047	putative PBP binding loops; other site
742013006048	ABC-ATPase subunit interface; other site
742013006049	phosphate transporter permease subunit PtsA; Provisional; Region: pstA; PRK11268
742013006050	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
742013006051	dimer interface [polypeptide binding]; other site
742013006052	conserved gate region; other site
742013006053	putative PBP binding loops; other site
742013006054	ABC-ATPase subunit interface; other site
742013006055	phosphate transporter ATP-binding protein; Provisional; Region: pstB; PRK10744
742013006056	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
742013006057	Walker A/P-loop; other site
742013006058	ATP binding site [chemical binding]; other site
742013006059	Q-loop/lid; other site
742013006060	ABC transporter signature motif; other site
742013006061	Walker B; other site
742013006062	D-loop; other site
742013006063	H-loop/switch region; other site
742013006064	transcriptional regulator PhoU; Provisional; Region: PRK11115
742013006065	PhoU domain; Region: PhoU; pfam01895
742013006066	PhoU domain; Region: PhoU; pfam01895
742013006067	phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154
742013006068	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
742013006069	active site
742013006070	phosphorylation site [posttranslational modification]
742013006071	intermolecular recognition site; other site
742013006072	dimerization interface [polypeptide binding]; other site
742013006073	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
742013006074	DNA binding site [nucleotide binding]
742013006075	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
742013006076	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
742013006077	putative active site [active]
742013006078	heme pocket [chemical binding]; other site
742013006079	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
742013006080	dimer interface [polypeptide binding]; other site
742013006081	phosphorylation site [posttranslational modification]
742013006082	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
742013006083	ATP binding site [chemical binding]; other site
742013006084	Mg2+ binding site [ion binding]; other site
742013006085	G-X-G motif; other site
742013006086	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131
742013006087	putative efflux protein, MATE family; Region: matE; TIGR00797
742013006088	cation binding site [ion binding]; other site
742013006089	50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678
742013006090	Helix-turn-helix domain; Region: HTH_17; pfam12728
742013006091	Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416
742013006092	Citrate synthase (CS) catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the oxidative citric acid cycle (TCA or Krebs cycle). Peroxisomal CS is involved in the glyoxylate...; Region: citrate_synt_like_2; cd06102
742013006093	Citrate synthase [Energy production and conversion]; Region: GltA; COG0372
742013006094	dimer interface [polypeptide binding]; other site
742013006095	active site
742013006096	oxalacetate/citrate binding site [chemical binding]; other site
742013006097	citrylCoA binding site [chemical binding]; other site
742013006098	coenzyme A binding site [chemical binding]; other site
742013006099	catalytic triad [active]
742013006100	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
742013006101	CoA-transferase family III; Region: CoA_transf_3; pfam02515
742013006102	transcription termination factor Rho; Provisional; Region: rho; PRK09376
742013006103	Rho termination factor, N-terminal domain; Region: Rho_N; smart00959
742013006104	Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459
742013006105	RNA binding site [nucleotide binding]; other site
742013006106	Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128
742013006107	multimer interface [polypeptide binding]; other site
742013006108	Walker A motif; other site
742013006109	ATP binding site [chemical binding]; other site
742013006110	Walker B motif; other site
742013006111	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
742013006112	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
742013006113	catalytic residues [active]
742013006114	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
742013006115	uncharacterized flavoprotein, PP_4765 family; Region: flavo_PP4765; TIGR03862
742013006116	DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397
742013006117	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
742013006118	Walker A motif; other site
742013006119	ATP binding site [chemical binding]; other site
742013006120	Walker B motif; other site
742013006121	arginine finger; other site
742013006122	DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169
742013006123	hypothetical protein; Validated; Region: PRK00153
742013006124	recombination protein RecR; Reviewed; Region: recR; PRK00076
742013006125	RecR protein; Region: RecR; pfam02132
742013006126	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
742013006127	putative active site [active]
742013006128	putative metal-binding site [ion binding]; other site
742013006129	tetramer interface [polypeptide binding]; other site
742013006130	MAPEG family; Region: MAPEG; cl09190
742013006131	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432
742013006132	NMT1/THI5 like; Region: NMT1; pfam09084
742013006133	membrane-bound lytic murein transglycosylase D; Provisional; Region: mltD; PRK10783
742013006134	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
742013006135	N-acetyl-D-glucosamine binding site [chemical binding]; other site
742013006136	catalytic residue [active]
742013006137	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
742013006138	hydroxyacylglutathione hydrolase; Region: GSH_gloB; TIGR03413
742013006139	Methyltransferase domain; Region: Methyltransf_11; pfam08241
742013006140	RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278
742013006141	RNA/DNA hybrid binding site [nucleotide binding]; other site
742013006142	active site
742013006143	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
742013006144	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
742013006145	trimer interface [polypeptide binding]; other site
742013006146	eyelet of channel; other site
742013006147	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
742013006148	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
742013006149	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085
742013006150	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
742013006151	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
742013006152	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
742013006153	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
742013006154	Clavaminic acid synthetase (CAS) -like;  CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184
742013006155	Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175
742013006156	active site
742013006157	iron coordination sites [ion binding]; other site
742013006158	substrate binding pocket [chemical binding]; other site
742013006159	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
742013006160	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
742013006161	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
742013006162	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
742013006163	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
742013006164	catalytic residues [active]
742013006165	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
742013006166	dimer interface [polypeptide binding]; other site
742013006167	putative functional site; other site
742013006168	putative MPT binding site; other site
742013006169	molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317
742013006170	MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503
742013006171	GTP binding site; other site
742013006172	molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164
742013006173	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
742013006174	FeS/SAM binding site; other site
742013006175	Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463
742013006176	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
742013006177	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231
742013006178	NAD(P) binding site [chemical binding]; other site
742013006179	active site
742013006180	Protein of unknown function (DUF2889); Region: DUF2889; pfam11136
742013006181	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
742013006182	Uncharacterized Saccharopolyspora spinosa aldehyde dehydrogenase (AAS00426)-like; Region: ALDH_AAS00426; cd07109
742013006183	NAD(P) binding site [chemical binding]; other site
742013006184	catalytic residues [active]
742013006185	catalytic residues [active]
742013006186	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
742013006187	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
742013006188	ligand binding site [chemical binding]; other site
742013006189	flexible hinge region; other site
742013006190	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
742013006191	non-specific DNA interactions [nucleotide binding]; other site
742013006192	DNA binding site [nucleotide binding]
742013006193	sequence specific DNA binding site [nucleotide binding]; other site
742013006194	putative cAMP binding site [chemical binding]; other site
742013006195	Predicted membrane protein [Function unknown]; Region: COG4539
742013006196	Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412
742013006197	dimer interface [polypeptide binding]; other site
742013006198	substrate binding site [chemical binding]; other site
742013006199	metal binding sites [ion binding]; metal-binding site
742013006200	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
742013006201	dimerization interface [polypeptide binding]; other site
742013006202	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
742013006203	dimer interface [polypeptide binding]; other site
742013006204	putative CheW interface [polypeptide binding]; other site
742013006205	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
742013006206	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
742013006207	dimerization interface [polypeptide binding]; other site
742013006208	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
742013006209	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
742013006210	dimer interface [polypeptide binding]; other site
742013006211	putative CheW interface [polypeptide binding]; other site
742013006212	Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; cl17497
742013006213	Protein of unknown function, DUF482; Region: DUF482; pfam04339
742013006214	NAD synthetase; Provisional; Region: PRK13981
742013006215	Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570
742013006216	multimer interface [polypeptide binding]; other site
742013006217	active site
742013006218	catalytic triad [active]
742013006219	protein interface 1 [polypeptide binding]; other site
742013006220	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
742013006221	homodimer interface [polypeptide binding]; other site
742013006222	NAD binding pocket [chemical binding]; other site
742013006223	ATP binding pocket [chemical binding]; other site
742013006224	Mg binding site [ion binding]; other site
742013006225	active-site loop [active]
742013006226	Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347
742013006227	Nitrogen regulatory protein P-II; Region: P-II; smart00938
742013006228	Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695
742013006229	Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818
742013006230	RDD family; Region: RDD; pfam06271
742013006231	Protein of unknown function (DUF3106); Region: DUF3106; pfam11304
742013006232	Protein of unknown function (DUF3619); Region: DUF3619; pfam12279
742013006233	RNA polymerase factor sigma-70; Validated; Region: PRK09047
742013006234	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
742013006235	DNA binding residues [nucleotide binding]
742013006236	acetolactate synthase 3 catalytic subunit; Validated; Region: PRK06965
742013006237	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
742013006238	PYR/PP interface [polypeptide binding]; other site
742013006239	dimer interface [polypeptide binding]; other site
742013006240	TPP binding site [chemical binding]; other site
742013006241	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
742013006242	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
742013006243	TPP-binding site [chemical binding]; other site
742013006244	dimer interface [polypeptide binding]; other site
742013006245	acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895
742013006246	N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878
742013006247	putative valine binding site [chemical binding]; other site
742013006248	dimer interface [polypeptide binding]; other site
742013006249	Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369
742013006250	ketol-acid reductoisomerase; Provisional; Region: PRK05479
742013006251	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991
742013006252	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
742013006253	Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183
742013006254	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066
742013006255	2-isopropylmalate synthase; Validated; Region: PRK03739
742013006256	Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942
742013006257	active site
742013006258	catalytic residues [active]
742013006259	metal binding site [ion binding]; metal-binding site
742013006260	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917
742013006261	2-isopropylmalate synthase; Validated; Region: PRK00915
742013006262	2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940
742013006263	active site
742013006264	catalytic residues [active]
742013006265	metal binding site [ion binding]; metal-binding site
742013006266	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917
742013006267	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768
742013006268	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
742013006269	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
742013006270	Transcriptional regulator [Transcription]; Region: IclR; COG1414
742013006271	Bacterial transcriptional regulator; Region: IclR; pfam01614
742013006272	arginyl-tRNA-protein transferase; Provisional; Region: PRK01305
742013006273	Arginine-tRNA-protein transferase, N terminus; Region: ATE_N; pfam04376
742013006274	Arginine-tRNA-protein transferase, C terminus; Region: ATE_C; pfam04377
742013006275	leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301
742013006276	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2832
742013006277	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
742013006278	active site
742013006279	catalytic residues [active]
742013006280	metal binding site [ion binding]; metal-binding site
742013006281	xanthine permease; Region: pbuX; TIGR03173
742013006282	PII uridylyl-transferase; Provisional; Region: PRK03059
742013006283	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
742013006284	metal binding triad; other site
742013006285	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
742013006286	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
742013006287	Zn2+ binding site [ion binding]; other site
742013006288	Mg2+ binding site [ion binding]; other site
742013006289	ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900
742013006290	C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899
742013006291	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
742013006292	active site
742013006293	phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297
742013006294	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203
742013006295	dimerization interface [polypeptide binding]; other site
742013006296	ATP binding site [chemical binding]; other site
742013006297	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204
742013006298	dimerization interface [polypeptide binding]; other site
742013006299	ATP binding site [chemical binding]; other site
742013006300	Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
742013006301	putative active site [active]
742013006302	catalytic triad [active]
742013006303	probable DNA metabolism protein; Region: SAM_7_link_chp; TIGR03915
742013006304	putative DNA modification/repair radical SAM protein; Region: rSAM_link_UDG; TIGR03916
742013006305	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
742013006306	FeS/SAM binding site; other site
742013006307	SWIM zinc finger; Region: SWIM; pfam04434
742013006308	MoxR-like ATPases [General function prediction only]; Region: COG0714
742013006309	AAA domain (dynein-related subfamily); Region: AAA_5; pfam07728
742013006310	VWA domain containing CoxE-like protein; Region: VWA_CoxE; pfam05762
742013006311	VWA YIEM type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: VWA_YIEM_type; cd01462
742013006312	metal ion-dependent adhesion site (MIDAS); other site
742013006313	Protein of unknown function (DUF808); Region: DUF808; pfam05661
742013006314	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
742013006315	TPR motif; other site
742013006316	RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966
742013006317	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
742013006318	GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057
742013006319	C-terminal domain interface [polypeptide binding]; other site
742013006320	GSH binding site (G-site) [chemical binding]; other site
742013006321	dimer interface [polypeptide binding]; other site
742013006322	C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188
742013006323	N-terminal domain interface [polypeptide binding]; other site
742013006324	dimer interface [polypeptide binding]; other site
742013006325	substrate binding pocket (H-site) [chemical binding]; other site
742013006326	PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493
742013006327	ferrichrome outer membrane transporter; Provisional; Region: PRK10044
742013006328	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
742013006329	N-terminal plug; other site
742013006330	ligand-binding site [chemical binding]; other site
742013006331	Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712
742013006332	FecR protein; Region: FecR; pfam04773
742013006333	RNA polymerase sigma factor; Provisional; Region: PRK12528
742013006334	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
742013006335	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
742013006336	DNA binding residues [nucleotide binding]
742013006337	Outer membrane protein W [Cell envelope biogenesis, outer membrane]; Region: OmpW; COG3047
742013006338	dimethylhistidine N-methyltransferase; Region: egtD_ergothio; TIGR03438
742013006339	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
742013006340	Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017
742013006341	ergothioneine biosynthesis protein EgtB; Region: egtB_TIGR03440
742013006342	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
742013006343	O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK06084
742013006344	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
742013006345	homodimer interface [polypeptide binding]; other site
742013006346	substrate-cofactor binding pocket; other site
742013006347	pyridoxal 5'-phosphate binding site [chemical binding]; other site
742013006348	catalytic residue [active]
742013006349	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
742013006350	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
742013006351	metal binding site [ion binding]; metal-binding site
742013006352	active site
742013006353	I-site; other site
742013006354	DEDDy 3'-5' exonuclease domain of WRN and similar proteins; Region: WRN_exo; cd06141
742013006355	catalytic site [active]
742013006356	putative active site [active]
742013006357	putative substrate binding site [chemical binding]; other site
742013006358	enoyl-CoA hydratase; Provisional; Region: PRK07509
742013006359	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
742013006360	substrate binding site [chemical binding]; other site
742013006361	oxyanion hole (OAH) forming residues; other site
742013006362	trimer interface [polypeptide binding]; other site
742013006363	short chain dehydrogenase; Provisional; Region: PRK07677
742013006364	Trans-2-enoyl-CoA reductase (TER) and 2,4-dienoyl-CoA reductase (DECR), atypical (a) SDR; Region: TER_DECR_SDR_a; cd05369
742013006365	NAD(P) binding site [chemical binding]; other site
742013006366	substrate binding site [chemical binding]; other site
742013006367	homotetramer interface [polypeptide binding]; other site
742013006368	active site
742013006369	homodimer interface [polypeptide binding]; other site
742013006370	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
742013006371	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
742013006372	active site
742013006373	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187
742013006374	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
742013006375	Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929
742013006376	acyl-activating enzyme (AAE) consensus motif; other site
742013006377	acyl-activating enzyme (AAE) consensus motif; other site
742013006378	putative AMP binding site [chemical binding]; other site
742013006379	putative active site [active]
742013006380	putative CoA binding site [chemical binding]; other site
742013006381	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
742013006382	CoA-transferase family III; Region: CoA_transf_3; pfam02515
742013006383	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07008
742013006384	Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; Region: ttLC_FACS_AlkK_like; cd12119
742013006385	dimer interface [polypeptide binding]; other site
742013006386	acyl-activating enzyme (AAE) consensus motif; other site
742013006387	putative active site [active]
742013006388	AMP binding site [chemical binding]; other site
742013006389	putative CoA binding site [chemical binding]; other site
742013006390	Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_8; cd06343
742013006391	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
742013006392	putative ligand binding site [chemical binding]; other site
742013006393	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
742013006394	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
742013006395	substrate binding site [chemical binding]; other site
742013006396	oxyanion hole (OAH) forming residues; other site
742013006397	trimer interface [polypeptide binding]; other site
742013006398	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
742013006399	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
742013006400	TM-ABC transporter signature motif; other site
742013006401	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
742013006402	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
742013006403	TM-ABC transporter signature motif; other site
742013006404	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
742013006405	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
742013006406	Walker A/P-loop; other site
742013006407	ATP binding site [chemical binding]; other site
742013006408	Q-loop/lid; other site
742013006409	ABC transporter signature motif; other site
742013006410	Walker B; other site
742013006411	D-loop; other site
742013006412	H-loop/switch region; other site
742013006413	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
742013006414	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
742013006415	Walker A/P-loop; other site
742013006416	ATP binding site [chemical binding]; other site
742013006417	Q-loop/lid; other site
742013006418	ABC transporter signature motif; other site
742013006419	Walker B; other site
742013006420	D-loop; other site
742013006421	H-loop/switch region; other site
742013006422	acetyl-CoA acetyltransferase; Provisional; Region: PRK06504
742013006423	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
742013006424	dimer interface [polypeptide binding]; other site
742013006425	active site
742013006426	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
742013006427	NAD(P) binding site [chemical binding]; other site
742013006428	active site
742013006429	ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909
742013006430	AAA ATPase domain; Region: AAA_16; pfam13191
742013006431	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
742013006432	DNA binding residues [nucleotide binding]
742013006433	dimerization interface [polypeptide binding]; other site
742013006434	oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701
742013006435	The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767
742013006436	putative molybdopterin cofactor binding site [chemical binding]; other site
742013006437	The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787
742013006438	putative molybdopterin cofactor binding site; other site
742013006439	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
742013006440	Peptidase family U32; Region: Peptidase_U32; pfam01136
742013006441	Collagenase; Region: DUF3656; pfam12392
742013006442	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
742013006443	Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342
742013006444	dimerization interface [polypeptide binding]; other site
742013006445	ligand binding site [chemical binding]; other site
742013006446	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
742013006447	nucleoside/Zn binding site; other site
742013006448	dimer interface [polypeptide binding]; other site
742013006449	catalytic motif [active]
742013006450	haloalkane dehalogenase; Provisional; Region: PRK00870
742013006451	LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025
742013006452	dimer interface [polypeptide binding]; other site
742013006453	catalytic triad [active]
742013006454	Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000
742013006455	Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116
742013006456	Protein related to penicillin acylase [General function prediction only]; Region: COG2366
742013006457	Penicillin G acylase (PGA) belongs to a family of beta-lactam acylases that includes cephalosporin acylase (CA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_PGA_like; cd03747
742013006458	active site
742013006459	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
742013006460	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
742013006461	PGAP1-like protein; Region: PGAP1; pfam07819
742013006462	Predicted transcription regulator containing HTH domain [Transcription]; Region: COG5499
742013006463	Uncharacterized protein conserved in bacteria (DUF2136); Region: DUF2136; pfam09907
742013006464	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
742013006465	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
742013006466	ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178
742013006467	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
742013006468	dimer interface [polypeptide binding]; other site
742013006469	conserved gate region; other site
742013006470	putative PBP binding loops; other site
742013006471	ABC-ATPase subunit interface; other site
742013006472	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
742013006473	dimer interface [polypeptide binding]; other site
742013006474	conserved gate region; other site
742013006475	putative PBP binding loops; other site
742013006476	ABC-ATPase subunit interface; other site
742013006477	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
742013006478	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
742013006479	Walker A/P-loop; other site
742013006480	ATP binding site [chemical binding]; other site
742013006481	Q-loop/lid; other site
742013006482	ABC transporter signature motif; other site
742013006483	Walker B; other site
742013006484	D-loop; other site
742013006485	H-loop/switch region; other site
742013006486	TOBE domain; Region: TOBE_2; pfam08402
742013006487	Transcriptional regulator [Transcription]; Region: LysR; COG0583
742013006488	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
742013006489	LysR substrate binding domain; Region: LysR_substrate; pfam03466
742013006490	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
742013006491	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
742013006492	Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113
742013006493	4-hydroxyphenylpyruvate dioxygenase; Region: 4HPPD; TIGR01263
742013006494	N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342
742013006495	dimer interface [polypeptide binding]; other site
742013006496	C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250
742013006497	active site
742013006498	Fe binding site [ion binding]; other site
742013006499	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
742013006500	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
742013006501	active site
742013006502	catalytic tetrad [active]
742013006503	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
742013006504	salt bridge; other site
742013006505	non-specific DNA binding site [nucleotide binding]; other site
742013006506	sequence-specific DNA binding site [nucleotide binding]; other site
742013006507	Protein of unknown function (DUF2975); Region: DUF2975; pfam11188
742013006508	This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002
742013006509	putative deacylase active site [active]
742013006510	putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220
742013006511	Domain of unknown function (DUF4178); Region: DUF4178; pfam13785
742013006512	Predicted Zn-ribbon RNA-binding protein with a function in translation [Translation, ribosomal structure and biogenesis]; Region: COG2888
742013006513	Domain of unknown function (DUF4178); Region: DUF4178; pfam13785
742013006514	Domain of Unknown Function (DUF350); Region: DUF350; pfam03994
742013006515	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
742013006516	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
742013006517	N-terminal plug; other site
742013006518	ligand-binding site [chemical binding]; other site
742013006519	spermidine synthase; Provisional; Region: PRK03612
742013006520	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
742013006521	S-adenosylmethionine binding site [chemical binding]; other site
742013006522	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
742013006523	Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483
742013006524	catalytic motif [active]
742013006525	Catalytic residue [active]
742013006526	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666
742013006527	Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740
742013006528	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK00046
742013006529	FAD binding domain; Region: FAD_binding_4; pfam01565
742013006530	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
742013006531	SPW repeat; Region: SPW; pfam03779
742013006532	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
742013006533	Transcriptional regulator [Transcription]; Region: LysR; COG0583
742013006534	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
742013006535	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
742013006536	putative effector binding pocket; other site
742013006537	dimerization interface [polypeptide binding]; other site
742013006538	argininosuccinate synthase; Validated; Region: PRK05370
742013006539	argininosuccinate synthase; Provisional; Region: PRK13820
742013006540	Protein of unknown function (DUF1255); Region: DUF1255; pfam06865
742013006541	Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035
742013006542	ArsC family; Region: ArsC; pfam03960
742013006543	putative catalytic residues [active]
742013006544	Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285
742013006545	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
742013006546	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
742013006547	Sporulation related domain; Region: SPOR; pfam05036
742013006548	Colicin V production protein; Region: Colicin_V; pfam02674
742013006549	amidophosphoribosyltransferase; Provisional; Region: PRK09246
742013006550	Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of  glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715
742013006551	active site
742013006552	tetramer interface [polypeptide binding]; other site
742013006553	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
742013006554	active site
742013006555	O-succinylhomoserine sulfhydrylase; Validated; Region: PRK08133
742013006556	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
742013006557	homodimer interface [polypeptide binding]; other site
742013006558	substrate-cofactor binding pocket; other site
742013006559	pyridoxal 5'-phosphate binding site [chemical binding]; other site
742013006560	catalytic residue [active]
742013006561	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
742013006562	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
742013006563	active site
742013006564	HIGH motif; other site
742013006565	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
742013006566	active site
742013006567	KMSKS motif; other site
742013006568	Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538
742013006569	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
742013006570	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
742013006571	HlyD family secretion protein; Region: HlyD_3; pfam13437
742013006572	Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696
742013006573	Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347
742013006574	Nitrogen regulatory protein P-II; Region: P-II; smart00938
742013006575	extracytoplasmic-function sigma-70 factor; Validated; Region: PRK07037
742013006576	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
742013006577	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
742013006578	DNA binding residues [nucleotide binding]
742013006579	MbtH-like protein; Region: MbtH; cl01279
742013006580	Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208
742013006581	Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091
742013006582	4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648
742013006583	Taurine catabolism dioxygenase TauD, TfdA family; Region: TauD; pfam02668
742013006584	Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175
742013006585	substrate binding pocket [chemical binding]; other site
742013006586	active site
742013006587	iron coordination sites [ion binding]; other site
742013006588	acyl-CoA synthetase; Validated; Region: PRK05850
742013006589	Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931
742013006590	acyl-activating enzyme (AAE) consensus motif; other site
742013006591	active site
742013006592	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
742013006593	Condensation domain; Region: Condensation; pfam00668
742013006594	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
742013006595	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
742013006596	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
742013006597	acyl-activating enzyme (AAE) consensus motif; other site
742013006598	AMP binding site [chemical binding]; other site
742013006599	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
742013006600	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
742013006601	3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304
742013006602	active site
742013006603	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
742013006604	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
742013006605	ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953
742013006606	putative NADP binding site [chemical binding]; other site
742013006607	This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822
742013006608	active site
742013006609	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
742013006610	Condensation domain; Region: Condensation; pfam00668
742013006611	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
742013006612	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
742013006613	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
742013006614	acyl-activating enzyme (AAE) consensus motif; other site
742013006615	AMP binding site [chemical binding]; other site
742013006616	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
742013006617	Condensation domain; Region: Condensation; pfam00668
742013006618	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
742013006619	non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261
742013006620	Condensation domain; Region: Condensation; pfam00668
742013006621	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
742013006622	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
742013006623	acyl-activating enzyme (AAE) consensus motif; other site
742013006624	AMP binding site [chemical binding]; other site
742013006625	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
742013006626	Condensation domain; Region: Condensation; pfam00668
742013006627	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
742013006628	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
742013006629	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
742013006630	acyl-activating enzyme (AAE) consensus motif; other site
742013006631	AMP binding site [chemical binding]; other site
742013006632	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
742013006633	Condensation domain; Region: Condensation; pfam00668
742013006634	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
742013006635	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
742013006636	acyl-activating enzyme (AAE) consensus motif; other site
742013006637	AMP binding site [chemical binding]; other site
742013006638	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
742013006639	Condensation domain; Region: Condensation; pfam00668
742013006640	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
742013006641	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
742013006642	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
742013006643	acyl-activating enzyme (AAE) consensus motif; other site
742013006644	AMP binding site [chemical binding]; other site
742013006645	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
742013006646	Condensation domain; Region: Condensation; pfam00668
742013006647	The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117
742013006648	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
742013006649	acyl-activating enzyme (AAE) consensus motif; other site
742013006650	AMP binding site [chemical binding]; other site
742013006651	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
742013006652	Condensation domain; Region: Condensation; pfam00668
742013006653	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
742013006654	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
742013006655	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
742013006656	acyl-activating enzyme (AAE) consensus motif; other site
742013006657	AMP binding site [chemical binding]; other site
742013006658	Condensation domain; Region: Condensation; pfam00668
742013006659	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
742013006660	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
742013006661	acyl-activating enzyme (AAE) consensus motif; other site
742013006662	AMP binding site [chemical binding]; other site
742013006663	Condensation domain; Region: Condensation; pfam00668
742013006664	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
742013006665	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
742013006666	acyl-activating enzyme (AAE) consensus motif; other site
742013006667	AMP binding site [chemical binding]; other site
742013006668	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
742013006669	enterobactin synthase subunit F; Provisional; Region: entF; PRK10252
742013006670	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
742013006671	acyl-activating enzyme (AAE) consensus motif; other site
742013006672	AMP binding site [chemical binding]; other site
742013006673	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
742013006674	Secretin and TonB N terminus short domain; Region: STN; smart00965
742013006675	ferrichrome outer membrane transporter; Provisional; Region: PRK10044
742013006676	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
742013006677	N-terminal plug; other site
742013006678	ligand-binding site [chemical binding]; other site
742013006679	Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712
742013006680	FecR protein; Region: FecR; pfam04773
742013006681	DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595
742013006682	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
742013006683	DNA binding residues [nucleotide binding]
742013006684	L-lysine 6-monooxygenase (NADPH-requiring); Region: K_oxygenase; pfam13434
742013006685	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
742013006686	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
742013006687	Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523
742013006688	Siderophore biosynthesis protein domain; Region: AlcB; smart01006
742013006689	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
742013006690	cyclic peptide transporter; Region: cyc_pep_trnsptr; TIGR01194
742013006691	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
742013006692	ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228
742013006693	Walker A/P-loop; other site
742013006694	ATP binding site [chemical binding]; other site
742013006695	Q-loop/lid; other site
742013006696	ABC transporter signature motif; other site
742013006697	Walker B; other site
742013006698	D-loop; other site
742013006699	H-loop/switch region; other site
742013006700	Formyltransferase, catalytic core domain; Region: FMT_core; cl00395
742013006701	active site
742013006702	cosubstrate binding site; other site
742013006703	substrate binding site [chemical binding]; other site
742013006704	catalytic site [active]
742013006705	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08217
742013006706	17hydroxysteroid dehydrogenase type 10 (HSD10)-like, classical (c) SDRs; Region: HSD10-like_SDR_c; cd05371
742013006707	NAD binding site [chemical binding]; other site
742013006708	homodimer interface [polypeptide binding]; other site
742013006709	homotetramer interface [polypeptide binding]; other site
742013006710	active site
742013006711	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
742013006712	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
742013006713	Phasin protein; Region: Phasin_2; pfam09361
742013006714	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
742013006715	active site
742013006716	nicotinate phosphoribosyltransferase; Region: NAPRTase; TIGR01514
742013006717	Nicotinate phosphoribosyltransferase (NAPRTase), related to PncB. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting; Region: PncB_like; cd01401
742013006718	active site
742013006719	Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055
742013006720	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
742013006721	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
742013006722	D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301
742013006723	dimerization interface [polypeptide binding]; other site
742013006724	ligand binding site [chemical binding]; other site
742013006725	NADP binding site [chemical binding]; other site
742013006726	catalytic site [active]
742013006727	RmuC family; Region: RmuC; pfam02646
742013006728	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
742013006729	putative substrate translocation pore; other site
742013006730	Major Facilitator Superfamily; Region: MFS_1; pfam07690
742013006731	Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611
742013006732	Na+/H+ antiporter subunit; Region: PhaG_MnhG_YufB; pfam03334
742013006733	putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK06161
742013006734	putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK08965
742013006735	putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12666
742013006736	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
742013006737	putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK09094
742013006738	putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12648
742013006739	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662
742013006740	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
742013006741	Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111
742013006742	monovalent cation:proton antiporter; Region: 2a6301s02; TIGR00943
742013006743	DNA uptake protein and related DNA-binding proteins [DNA replication, recombination, and repair]; Region: ComEA; COG1555
742013006744	tetratricopeptide repeat protein; Provisional; Region: PRK11788
742013006745	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
742013006746	binding surface
742013006747	TPR motif; other site
742013006748	Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993
742013006749	Protein of unknown function (DUF1049); Region: DUF1049; pfam06305
742013006750	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
742013006751	IHF dimer interface [polypeptide binding]; other site
742013006752	IHF - DNA interface [nucleotide binding]; other site
742013006753	30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299
742013006754	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
742013006755	RNA binding site [nucleotide binding]; other site
742013006756	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
742013006757	RNA binding site [nucleotide binding]; other site
742013006758	S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688
742013006759	RNA binding site [nucleotide binding]; other site
742013006760	S1_RPS1_repeat_ec4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec4; cd05689
742013006761	RNA binding site [nucleotide binding]; other site
742013006762	S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec5; cd05690
742013006763	RNA binding site [nucleotide binding]; other site
742013006764	S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691
742013006765	RNA binding site [nucleotide binding]; other site
742013006766	bifunctional 3-phosphoshikimate 1-carboxyvinyltransferase/cytidine monophosphate kinase; Provisional; Region: PRK11860
742013006767	EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556
742013006768	hinge; other site
742013006769	active site
742013006770	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
742013006771	CMP-binding site; other site
742013006772	The sites determining sugar specificity; other site
742013006773	Prephenate dehydrogenase [Amino acid transport and metabolism]; Region: TyrA; COG0287
742013006774	prephenate dehydrogenase; Validated; Region: PRK08507
742013006775	Chorismate mutase type II; Region: CM_2; pfam01817
742013006776	Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077
742013006777	Prephenate dehydratase; Region: PDT; pfam00800
742013006778	C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905
742013006779	putative L-Phe binding site [chemical binding]; other site
742013006780	Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT).  PSAT is active as...; Region: PSAT_like; cd00611
742013006781	homodimer interface [polypeptide binding]; other site
742013006782	substrate-cofactor binding pocket; other site
742013006783	pyridoxal 5'-phosphate binding site [chemical binding]; other site
742013006784	catalytic residue [active]
742013006785	DNA gyrase subunit A; Validated; Region: PRK05560
742013006786	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
742013006787	CAP-like domain; other site
742013006788	active site
742013006789	primary dimer interface [polypeptide binding]; other site
742013006790	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
742013006791	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
742013006792	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
742013006793	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
742013006794	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
742013006795	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
742013006796	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
742013006797	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
742013006798	ligand binding site [chemical binding]; other site
742013006799	bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134
742013006800	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
742013006801	S-adenosylmethionine binding site [chemical binding]; other site
742013006802	phosphoglycolate phosphatase; Provisional; Region: PRK13222
742013006803	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915
742013006804	motif I; other site
742013006805	active site
742013006806	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
742013006807	motif II; other site
742013006808	H-NS histone family; Region: Histone_HNS; pfam00816
742013006809	Domain in histone-like proteins of HNS family; Region: HNS; smart00528
742013006810	Bacterial Ig-like domain; Region: Big_5; pfam13205
742013006811	YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486
742013006812	generic binding surface II; other site
742013006813	generic binding surface I; other site
742013006814	Mycoplasma pulmonis MnuA nuclease-like; Region: MnuA_DNase1-like; cd10283
742013006815	putative active site [active]
742013006816	putative catalytic site [active]
742013006817	putative Mg binding site IVb [ion binding]; other site
742013006818	putative phosphate binding site [ion binding]; other site
742013006819	putative DNA binding site [nucleotide binding]; other site
742013006820	putative Mg binding site IVa [ion binding]; other site
742013006821	IPTL-CTERM protein sorting domain; Region: IPTL_CTERM; TIGR04174
742013006822	type IV pilus biogenesis/stability protein PilW; Region: type_IV_pilW; TIGR02521
742013006823	RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279
742013006824	RNA/DNA hybrid binding site [nucleotide binding]; other site
742013006825	active site
742013006826	GST_N family, unknown subfamily 2; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_2; cd03047
742013006827	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
742013006828	putative C-terminal domain interface [polypeptide binding]; other site
742013006829	putative GSH binding site (G-site) [chemical binding]; other site
742013006830	putative dimer interface [polypeptide binding]; other site
742013006831	C-terminal, alpha helical domain of an unknown subfamily 2 of Glutathione S-transferases; Region: GST_C_2; cd03180
742013006832	putative N-terminal domain interface [polypeptide binding]; other site
742013006833	putative dimer interface [polypeptide binding]; other site
742013006834	putative substrate binding pocket (H-site) [chemical binding]; other site
742013006835	Type III secretion system lipoprotein chaperone (YscW); Region: YscW; cl15825
742013006836	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
742013006837	rRNA binding site [nucleotide binding]; other site
742013006838	predicted 30S ribosome binding site; other site
742013006839	phosphatidylserine decarboxylase; Reviewed; Region: psd; PRK00044
742013006840	Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492
742013006841	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
742013006842	Ferredoxin [Energy production and conversion]; Region: COG1146
742013006843	4Fe-4S binding domain; Region: Fer4; cl02805
742013006844	Domain of unknown function (DUF3470); Region: DUF3470; pfam11953
742013006845	GTPases - Sulfate adenylate transferase subunit 1 [Inorganic ion transport and metabolism]; Region: CysN; COG2895
742013006846	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
742013006847	G1 box; other site
742013006848	GTP/Mg2+ binding site [chemical binding]; other site
742013006849	G2 box; other site
742013006850	Switch I region; other site
742013006851	G3 box; other site
742013006852	Switch II region; other site
742013006853	G4 box; other site
742013006854	G5 box; other site
742013006855	Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787
742013006856	TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095
742013006857	sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039
742013006858	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
742013006859	Active Sites [active]
742013006860	3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175
742013006861	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
742013006862	Active Sites [active]
742013006863	Bacterial protein of unknown function (DUF934); Region: DUF934; pfam06073
742013006864	Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155
742013006865	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
742013006866	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
742013006867	putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608
742013006868	Walker A/P-loop; other site
742013006869	ATP binding site [chemical binding]; other site
742013006870	Q-loop/lid; other site
742013006871	ABC transporter signature motif; other site
742013006872	Walker B; other site
742013006873	D-loop; other site
742013006874	H-loop/switch region; other site
742013006875	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462
742013006876	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
742013006877	putative PBP binding regions; other site
742013006878	ABC-ATPase subunit  interface; other site
742013006879	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
742013006880	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
742013006881	Metal binding protein HemV-2.  These proteins are predicted to function as initial receptors in ABC transport of metal ions.  They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and ligand binding...; Region: HemV-2; cd01147
742013006882	putative metal binding site [ion binding]; other site
742013006883	Protein of unknown function (DUF2478); Region: DUF2478; pfam10649
742013006884	ABC-type tungstate transport system, permease component [Coenzyme metabolism]; Region: TupB; COG2998
742013006885	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
742013006886	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
742013006887	N-terminal plug; other site
742013006888	ligand-binding site [chemical binding]; other site
742013006889	Uncharacterized conserved protein [Function unknown]; Region: COG4121
742013006890	bifunctional tRNA (mnm(5)s(2)U34)-methyltransferase/FAD-dependent cmnm(5)s(2)U34 oxidoreductase; Reviewed; Region: mnmC; PRK01747
742013006891	Predicted membrane protein [Function unknown]; Region: COG2860
742013006892	UPF0126 domain; Region: UPF0126; pfam03458
742013006893	UPF0126 domain; Region: UPF0126; pfam03458
742013006894	oxidative damage protection protein; Provisional; Region: PRK05408
742013006895	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
742013006896	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
742013006897	substrate binding pocket [chemical binding]; other site
742013006898	membrane-bound complex binding site; other site
742013006899	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
742013006900	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
742013006901	substrate binding pocket [chemical binding]; other site
742013006902	membrane-bound complex binding site; other site
742013006903	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
742013006904	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
742013006905	substrate binding pocket [chemical binding]; other site
742013006906	ABC transporter periplasmic binding protein, urea carboxylase region; Region: ABC_peri_uca; TIGR03427
742013006907	membrane-bound complex binding site; other site
742013006908	alkanesulfonate monooxygenase; Provisional; Region: PRK00719
742013006909	Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094
742013006910	active site
742013006911	dimer interface [polypeptide binding]; other site
742013006912	non-prolyl cis peptide bond; other site
742013006913	insertion regions; other site
742013006914	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
742013006915	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
742013006916	putative PBP binding loops; other site
742013006917	dimer interface [polypeptide binding]; other site
742013006918	ABC-ATPase subunit interface; other site
742013006919	aliphatic sulfonates transport ATP-binding subunit; Provisional; Region: ssuB; PRK11247
742013006920	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
742013006921	Walker A/P-loop; other site
742013006922	ATP binding site [chemical binding]; other site
742013006923	Q-loop/lid; other site
742013006924	ABC transporter signature motif; other site
742013006925	Walker B; other site
742013006926	D-loop; other site
742013006927	H-loop/switch region; other site
742013006928	Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585
742013006929	Predicted integral membrane protein (DUF2269); Region: DUF2269; pfam10027
742013006930	DoxX-like family; Region: DoxX_3; pfam13781
742013006931	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
742013006932	NADH(P)-binding; Region: NAD_binding_10; pfam13460
742013006933	NAD(P) binding site [chemical binding]; other site
742013006934	active site
742013006935	Predicted transcriptional regulators [Transcription]; Region: COG1510
742013006936	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
742013006937	dimerization interface [polypeptide binding]; other site
742013006938	putative DNA binding site [nucleotide binding]; other site
742013006939	putative Zn2+ binding site [ion binding]; other site
742013006940	23S rRNA m(5)U1939 methyltransferase; Reviewed; Region: rumA; PRK13168
742013006941	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
742013006942	Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670
742013006943	YccA-like proteins; Region: YccA_like; cd10433
742013006944	Uncharacterized protein, possibly involved in utilization of glycolate and propanediol [General function prediction only]; Region: GlcG; COG3193
742013006945	Hemin uptake protein hemP; Region: hemP; pfam10636
742013006946	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
742013006947	Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472
742013006948	Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811
742013006949	Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810
742013006950	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
742013006951	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
742013006952	Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809
742013006953	FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070
742013006954	active site
742013006955	substrate binding site [chemical binding]; other site
742013006956	FMN binding site [chemical binding]; other site
742013006957	putative catalytic residues [active]
742013006958	SWI complex, BAF60b domains; Region: SWIB; smart00151
742013006959	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
742013006960	EamA-like transporter family; Region: EamA; pfam00892
742013006961	EamA-like transporter family; Region: EamA; pfam00892
742013006962	isocitrate lyase; Provisional; Region: PRK15063
742013006963	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
742013006964	tetramer interface [polypeptide binding]; other site
742013006965	active site
742013006966	Mg2+/Mn2+ binding site [ion binding]; other site
742013006967	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413
742013006968	TGS _ThrRS_N:  ThrRS (threonyl-tRNA Synthetase)  is a class II tRNA synthetase that couples threonine to its cognate tRNA.  In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667
742013006969	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
742013006970	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
742013006971	active site
742013006972	dimer interface [polypeptide binding]; other site
742013006973	motif 1; other site
742013006974	motif 2; other site
742013006975	motif 3; other site
742013006976	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
742013006977	anticodon binding site; other site
742013006978	translation initiation factor IF-3; Reviewed; Region: infC; PRK00028
742013006979	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
742013006980	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
742013006981	50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172
742013006982	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
742013006983	23S rRNA binding site [nucleotide binding]; other site
742013006984	L21 binding site [polypeptide binding]; other site
742013006985	L13 binding site [polypeptide binding]; other site
742013006986	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
742013006987	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
742013006988	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
742013006989	dimer interface [polypeptide binding]; other site
742013006990	motif 1; other site
742013006991	active site
742013006992	motif 2; other site
742013006993	motif 3; other site
742013006994	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
742013006995	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
742013006996	putative tRNA-binding site [nucleotide binding]; other site
742013006997	B3/4 domain; Region: B3_4; pfam03483
742013006998	tRNA synthetase B5 domain; Region: B5; smart00874
742013006999	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
742013007000	dimer interface [polypeptide binding]; other site
742013007001	motif 1; other site
742013007002	motif 3; other site
742013007003	motif 2; other site
742013007004	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; smart00896
742013007005	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
742013007006	IHF - DNA interface [nucleotide binding]; other site
742013007007	IHF dimer interface [polypeptide binding]; other site
742013007008	Helix-Turn-Helix DNA binding domain of putative MlrA-like transcription regulators; Region: HTH_MlrA-like_sg2; cd04765
742013007009	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
742013007010	DNA binding residues [nucleotide binding]
742013007011	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
742013007012	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
742013007013	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
742013007014	dimerization interface [polypeptide binding]; other site
742013007015	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
742013007016	FAD binding domain; Region: FAD_binding_4; pfam01565
742013007017	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
742013007018	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
742013007019	dimer interface [polypeptide binding]; other site
742013007020	ssDNA binding site [nucleotide binding]; other site
742013007021	tetramer (dimer of dimers) interface [polypeptide binding]; other site
742013007022	ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464
742013007023	NLPA lipoprotein; Region: Lipoprotein_9; pfam03180
742013007024	Nitroreductase family. Members of this family utilize FMN as a cofactor and catalyze reduction of a variety of nitroaromatic compounds, including nitrofurans, nitrobenzens, nitrophenol, nitrobenzoate and quinones by using either NADH or NADPH as a source...; Region: Nitroreductase; cd02136
742013007025	putative FMN binding site [chemical binding]; other site
742013007026	Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938
742013007027	acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930
742013007028	active site
742013007029	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
742013007030	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
742013007031	acyl-activating enzyme (AAE) consensus motif; other site
742013007032	Adenylate forming domain, Class I; Region: AFD_class_I; cd04433
742013007033	AMP binding site [chemical binding]; other site
742013007034	active site
742013007035	acyl-activating enzyme (AAE) consensus motif; other site
742013007036	CoA binding site [chemical binding]; other site
742013007037	BioY family; Region: BioY; pfam02632
742013007038	Cobalt transport protein; Region: CbiQ; cl00463
742013007039	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
742013007040	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
742013007041	Walker A/P-loop; other site
742013007042	ATP binding site [chemical binding]; other site
742013007043	Q-loop/lid; other site
742013007044	ABC transporter signature motif; other site
742013007045	Walker B; other site
742013007046	D-loop; other site
742013007047	H-loop/switch region; other site
742013007048	ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258
742013007049	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
742013007050	Walker A/P-loop; other site
742013007051	ATP binding site [chemical binding]; other site
742013007052	Q-loop/lid; other site
742013007053	ABC transporter signature motif; other site
742013007054	Walker B; other site
742013007055	D-loop; other site
742013007056	H-loop/switch region; other site
742013007057	ABC-type metal ion transport system, permease component [Inorganic ion transport and metabolism]; Region: AbcD; COG2011
742013007058	NLPA lipoprotein; Region: Lipoprotein_9; pfam03180
742013007059	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
742013007060	Predicted flavoprotein [General function prediction only]; Region: COG0431
742013007061	haloacid dehalogenase-like hydrolase family protein; Region: PLN02919
742013007062	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
742013007063	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
742013007064	LysR family transcriptional regulator; Provisional; Region: PRK14997
742013007065	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
742013007066	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_4; cd08473
742013007067	putative effector binding pocket; other site
742013007068	putative dimerization interface [polypeptide binding]; other site
742013007069	Serine hydrolase; Region: Ser_hydrolase; pfam06821
742013007070	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
742013007071	ABC-type sulfate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: Sbp; COG1613
742013007072	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
742013007073	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
742013007074	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
742013007075	dimer interface [polypeptide binding]; other site
742013007076	conserved gate region; other site
742013007077	putative PBP binding loops; other site
742013007078	ABC-ATPase subunit interface; other site
742013007079	sulfate transport protein; Provisional; Region: cysT; CHL00187
742013007080	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
742013007081	dimer interface [polypeptide binding]; other site
742013007082	conserved gate region; other site
742013007083	putative PBP binding loops; other site
742013007084	ABC-ATPase subunit interface; other site
742013007085	ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118
742013007086	ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296
742013007087	Walker A/P-loop; other site
742013007088	ATP binding site [chemical binding]; other site
742013007089	Q-loop/lid; other site
742013007090	ABC transporter signature motif; other site
742013007091	Walker B; other site
742013007092	D-loop; other site
742013007093	H-loop/switch region; other site
742013007094	TOBE-like domain; Region: TOBE_3; pfam12857
742013007095	Disulfide bond formation protein DsbB; Region: DsbB; pfam02600
742013007096	dihydroxyacetone kinase; Provisional; Region: PRK14479
742013007097	dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557
742013007098	DAK2 domain; Region: Dak2; pfam02734
742013007099	ribose-5-phosphate isomerase B; Provisional; Region: PRK05571
742013007100	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
742013007101	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
742013007102	Walker A/P-loop; other site
742013007103	ATP binding site [chemical binding]; other site
742013007104	Q-loop/lid; other site
742013007105	ABC transporter signature motif; other site
742013007106	Walker B; other site
742013007107	D-loop; other site
742013007108	H-loop/switch region; other site
742013007109	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
742013007110	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879
742013007111	Periplasmic binding proteins specific to rhizopines; Region: PBP1_rhizopine_binding_like; cd06301
742013007112	putative ligand binding site [chemical binding]; other site
742013007113	short chain dehydrogenase; Provisional; Region: PRK06841
742013007114	classical (c) SDRs; Region: SDR_c; cd05233
742013007115	NAD(P) binding site [chemical binding]; other site
742013007116	active site
742013007117	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
742013007118	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
742013007119	TM-ABC transporter signature motif; other site
742013007120	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
742013007121	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
742013007122	NAD(P) binding site [chemical binding]; other site
742013007123	MarR family; Region: MarR_2; pfam12802
742013007124	Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390
742013007125	Putative sugar-binding domain; Region: Sugar-bind; pfam04198
742013007126	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
742013007127	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
742013007128	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
742013007129	C-terminal, alpha helical domain of an unknown subfamily 5 of Glutathione S-transferases; Region: GST_C_5; cd03196
742013007130	putative N-terminal domain interface [polypeptide binding]; other site
742013007131	putative dimer interface [polypeptide binding]; other site
742013007132	putative substrate binding pocket (H-site) [chemical binding]; other site
742013007133	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
742013007134	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
742013007135	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
742013007136	dimerization interface [polypeptide binding]; other site
742013007137	Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354
742013007138	N-acetylglutamate synthase; Validated; Region: PRK05279
742013007139	AAK_NAGS-ABP: N-acetylglutamate (NAG) kinase-like domain of the NAG Synthase (NAGS) of the arginine-biosynthesis pathway (ABP) found in gamma- and beta-proteobacteria and higher plant chloroplasts. Domain architecture of these NAGS consisted of an...; Region: AAK_NAGS-ABP; cd04237
742013007140	putative feedback inhibition sensing region; other site
742013007141	putative nucleotide binding site [chemical binding]; other site
742013007142	putative substrate binding site [chemical binding]; other site
742013007143	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
742013007144	Coenzyme A binding pocket [chemical binding]; other site
742013007145	Outer membrane efflux protein; Region: OEP; pfam02321
742013007146	Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566
742013007147	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
742013007148	HlyD family secretion protein; Region: HlyD_3; pfam13437
742013007149	YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061
742013007150	ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698
742013007151	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
742013007152	Domain of unknown function (DUF4124); Region: DUF4124; pfam13511
742013007153	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
742013007154	Major Facilitator Superfamily; Region: MFS_1; pfam07690
742013007155	putative substrate translocation pore; other site
742013007156	leucine transcriptional activator; Reviewed; Region: leuO; PRK09508
742013007157	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
742013007158	The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417
742013007159	substrate binding pocket [chemical binding]; other site
742013007160	dimerization interface [polypeptide binding]; other site
742013007161	Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618
742013007162	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
742013007163	active site
742013007164	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
742013007165	Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405
742013007166	Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019
742013007167	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
742013007168	Transcriptional regulator [Transcription]; Region: LysR; COG0583
742013007169	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
742013007170	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
742013007171	dimerization interface [polypeptide binding]; other site
742013007172	4-Oxalocrotonate Tautomerase:  Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235
742013007173	dimer interface [polypeptide binding]; other site
742013007174	hexamer interface [polypeptide binding]; other site
742013007175	active site 2 [active]
742013007176	4-Oxalocrotonate Tautomerase:  Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235
742013007177	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
742013007178	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
742013007179	dimerization interface [polypeptide binding]; other site
742013007180	RNA ligase; Region: RNA_ligase; pfam09414
742013007181	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
742013007182	Zn2+ binding site [ion binding]; other site
742013007183	Mg2+ binding site [ion binding]; other site
742013007184	AAA domain; Region: AAA_33; pfam13671
742013007185	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
742013007186	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
742013007187	aconitate hydratase; Provisional; Region: acnA; PRK12881
742013007188	Aconitase A catalytic domain; Region: AcnA_IRP; cd01586
742013007189	substrate binding site [chemical binding]; other site
742013007190	ligand binding site [chemical binding]; other site
742013007191	Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215
742013007192	substrate binding site [chemical binding]; other site
742013007193	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
742013007194	DNA-binding site [nucleotide binding]; DNA binding site
742013007195	Transcriptional regulators [Transcription]; Region: FadR; COG2186
742013007196	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414
742013007197	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
742013007198	Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062
742013007199	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
742013007200	substrate binding pocket [chemical binding]; other site
742013007201	membrane-bound complex binding site; other site
742013007202	Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282
742013007203	Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385
742013007204	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
742013007205	putative active site [active]
742013007206	putative metal binding site [ion binding]; other site
742013007207	ATP-dependent helicase HrpA; Region: DEAH_box_HrpA; TIGR01967
742013007208	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
742013007209	ATP binding site [chemical binding]; other site
742013007210	putative Mg++ binding site [ion binding]; other site
742013007211	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
742013007212	nucleotide binding region [chemical binding]; other site
742013007213	ATP-binding site [chemical binding]; other site
742013007214	Helicase associated domain (HA2); Region: HA2; pfam04408
742013007215	Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717
742013007216	Domain of unknown function (DUF3418); Region: DUF3418; pfam11898
742013007217	Isochorismatase family; Region: Isochorismatase; pfam00857
742013007218	Nicotinamidase_ related amidohydrolases.  Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014
742013007219	catalytic triad [active]
742013007220	conserved cis-peptide bond; other site
742013007221	nitrous oxide reductase family maturation protein NosD; Region: NosD_copper_fam; TIGR04247
742013007222	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
742013007223	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
742013007224	RHS protein; Region: RHS; pfam03527
742013007225	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
742013007226	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
742013007227	LysR family transcriptional regulator; Provisional; Region: PRK14997
742013007228	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
742013007229	putative effector binding pocket; other site
742013007230	dimerization interface [polypeptide binding]; other site
742013007231	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
742013007232	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08314
742013007233	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
742013007234	Putative long-chain fatty acid CoA ligase; Region: LC_FACS_like; cd05935
742013007235	acyl-activating enzyme (AAE) consensus motif; other site
742013007236	putative AMP binding site [chemical binding]; other site
742013007237	putative active site [active]
742013007238	putative CoA binding site [chemical binding]; other site
742013007239	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
742013007240	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
742013007241	Coenzyme A binding pocket [chemical binding]; other site
742013007242	Beta-lactamase class D [Defense mechanisms]; Region: COG2602
742013007243	Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182
742013007244	PepSY-associated TM helix; Region: PepSY_TM_3; pfam13706
742013007245	PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703
742013007246	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
742013007247	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
742013007248	N-terminal plug; other site
742013007249	ligand-binding site [chemical binding]; other site
742013007250	Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492
742013007251	Predicted transcriptional regulator [Transcription]; Region: COG1959
742013007252	Transcriptional regulator; Region: Rrf2; pfam02082
742013007253	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
742013007254	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
742013007255	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
742013007256	trimer interface [polypeptide binding]; other site
742013007257	eyelet of channel; other site
742013007258	Tannase and feruloyl esterase; Region: Tannase; pfam07519
742013007259	Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159
742013007260	active site
742013007261	MarR family; Region: MarR_2; pfam12802
742013007262	Transcription factor zinc-finger; Region: zf-TFIIB; cl01565
742013007263	putative hydrolase, CocE/NonD family; Region: /NonD; TIGR00976
742013007264	X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; pfam08530
742013007265	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
742013007266	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
742013007267	Protein of unknown function (DUF418); Region: DUF418; pfam04235
742013007268	Acyl-protein synthetase, LuxE; Region: LuxE; pfam04443
742013007269	Acyl-CoA reductase LuxC; Region: ALDH_Acyl-CoA-Red_LuxC; cd07080
742013007270	Acyl-CoA reductase (LuxC); Region: LuxC; pfam05893
742013007271	putative catalytic cysteine [active]
742013007272	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
742013007273	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
742013007274	Walker A/P-loop; other site
742013007275	ATP binding site [chemical binding]; other site
742013007276	Q-loop/lid; other site
742013007277	ABC transporter signature motif; other site
742013007278	Walker B; other site
742013007279	D-loop; other site
742013007280	H-loop/switch region; other site
742013007281	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
742013007282	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
742013007283	NMT1/THI5 like; Region: NMT1; pfam09084
742013007284	TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122
742013007285	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
742013007286	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
742013007287	NAD(P) binding site [chemical binding]; other site
742013007288	active site
742013007289	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
742013007290	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
742013007291	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
742013007292	dimer interface [polypeptide binding]; other site
742013007293	putative CheW interface [polypeptide binding]; other site
742013007294	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
742013007295	The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414
742013007296	dimerization interface [polypeptide binding]; other site
742013007297	substrate binding pocket [chemical binding]; other site
742013007298	VCBS repeat; Region: VCBS_repeat; TIGR01965
742013007299	type I secretion C-terminal target domain (VC_A0849 subclass); Region: T1SS_VCA0849; TIGR03661
742013007300	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657
742013007301	dinuclear metal binding motif [ion binding]; other site
742013007302	ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974
742013007303	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
742013007304	membrane-bound complex binding site; other site
742013007305	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
742013007306	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
742013007307	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
742013007308	active site
742013007309	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
742013007310	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
742013007311	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
742013007312	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
742013007313	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
742013007314	Aspartate racemase [Cell envelope biogenesis, outer membrane]; Region: RacX; COG1794
742013007315	aspartate racemase; Region: asp_race; TIGR00035
742013007316	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
742013007317	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
742013007318	DNA-binding site [nucleotide binding]; DNA binding site
742013007319	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
742013007320	pyridoxal 5'-phosphate binding site [chemical binding]; other site
742013007321	homodimer interface [polypeptide binding]; other site
742013007322	catalytic residue [active]
742013007323	dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606
742013007324	Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995
742013007325	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_24; cd09012
742013007326	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
742013007327	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
742013007328	DNA binding residues [nucleotide binding]
742013007329	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
742013007330	NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370
742013007331	NAD(P) binding site [chemical binding]; other site
742013007332	active site
742013007333	2-dehydropantoate 2-reductase; Provisional; Region: PRK12921
742013007334	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
742013007335	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
742013007336	Protein of unknown function (DUF1501); Region: DUF1501; pfam07394
742013007337	Protein of unknown function (DUF1800); Region: DUF1800; pfam08811
742013007338	ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776
742013007339	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
742013007340	ATP binding site [chemical binding]; other site
742013007341	Mg++ binding site [ion binding]; other site
742013007342	motif III; other site
742013007343	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
742013007344	nucleotide binding region [chemical binding]; other site
742013007345	ATP-binding site [chemical binding]; other site
742013007346	RNA recognition motif in Escherichia coli RNA helicase dbpA and similar proteins; Region: RRM_EcDbpA_like; cd12501
742013007347	putative RNA binding site [nucleotide binding]; other site
742013007348	Cache domain; Region: Cache_1; pfam02743
742013007349	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
742013007350	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
742013007351	metal binding site [ion binding]; metal-binding site
742013007352	active site
742013007353	I-site; other site
742013007354	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
742013007355	MarR family; Region: MarR; pfam01047
742013007356	Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657
742013007357	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
742013007358	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
742013007359	Type I periplasmic binding component of active transport systems that are predicted to be involved in 2-nitrobenzoic acid degradation pathway; Region: PBP1_Nba_like; cd06359
742013007360	putative ligand binding site [chemical binding]; other site
742013007361	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
742013007362	TM-ABC transporter signature motif; other site
742013007363	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
742013007364	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
742013007365	TM-ABC transporter signature motif; other site
742013007366	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
742013007367	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
742013007368	Walker A/P-loop; other site
742013007369	ATP binding site [chemical binding]; other site
742013007370	Q-loop/lid; other site
742013007371	ABC transporter signature motif; other site
742013007372	Walker B; other site
742013007373	D-loop; other site
742013007374	H-loop/switch region; other site
742013007375	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
742013007376	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
742013007377	Walker A/P-loop; other site
742013007378	ATP binding site [chemical binding]; other site
742013007379	Q-loop/lid; other site
742013007380	ABC transporter signature motif; other site
742013007381	Walker B; other site
742013007382	D-loop; other site
742013007383	H-loop/switch region; other site
742013007384	type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361
742013007385	Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954
742013007386	Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717
742013007387	Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; cl01733
742013007388	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
742013007389	RHS Repeat; Region: RHS_repeat; pfam05593
742013007390	RHS Repeat; Region: RHS_repeat; pfam05593
742013007391	RHS Repeat; Region: RHS_repeat; cl11982
742013007392	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
742013007393	RHS protein; Region: RHS; pfam03527
742013007394	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
742013007395	salicylyl-CoA 5-hydroxylase; Reviewed; Region: PRK08255
742013007396	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
742013007397	Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis.  Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932
742013007398	active site
742013007399	FMN binding site [chemical binding]; other site
742013007400	substrate binding site [chemical binding]; other site
742013007401	homotetramer interface [polypeptide binding]; other site
742013007402	catalytic residue [active]
742013007403	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
742013007404	classical (c) SDRs; Region: SDR_c; cd05233
742013007405	NAD(P) binding site [chemical binding]; other site
742013007406	active site
742013007407	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
742013007408	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
742013007409	substrate binding site [chemical binding]; other site
742013007410	oxyanion hole (OAH) forming residues; other site
742013007411	trimer interface [polypeptide binding]; other site
742013007412	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
742013007413	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
742013007414	active site
742013007415	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
742013007416	Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365
742013007417	acyl-activating enzyme (AAE) consensus motif; other site
742013007418	AMP binding site [chemical binding]; other site
742013007419	active site
742013007420	CoA binding site [chemical binding]; other site
742013007421	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
742013007422	active site
742013007423	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
742013007424	homotrimer interaction site [polypeptide binding]; other site
742013007425	putative active site [active]
742013007426	H-NS histone family; Region: Histone_HNS; pfam00816
742013007427	Domain in histone-like proteins of HNS family; Region: HNS; smart00528
742013007428	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
742013007429	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
742013007430	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
742013007431	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
742013007432	N-terminal plug; other site
742013007433	ligand-binding site [chemical binding]; other site
742013007434	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
742013007435	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
742013007436	Walker A/P-loop; other site
742013007437	ATP binding site [chemical binding]; other site
742013007438	Q-loop/lid; other site
742013007439	ABC transporter signature motif; other site
742013007440	Walker B; other site
742013007441	D-loop; other site
742013007442	H-loop/switch region; other site
742013007443	ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277
742013007444	Domain of unknown function (DUF3526); Region: DUF3526; pfam12040
742013007445	Domain of unknown function (DUF3526); Region: DUF3526; pfam12040
742013007446	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
742013007447	metal binding site 2 [ion binding]; metal-binding site
742013007448	putative DNA binding helix; other site
742013007449	metal binding site 1 [ion binding]; metal-binding site
742013007450	dimer interface [polypeptide binding]; other site
742013007451	structural Zn2+ binding site [ion binding]; other site
742013007452	short chain dehydrogenase; Provisional; Region: PRK07478
742013007453	classical (c) SDRs; Region: SDR_c; cd05233
742013007454	NAD(P) binding site [chemical binding]; other site
742013007455	active site
742013007456	DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986
742013007457	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
742013007458	The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414
742013007459	dimerization interface [polypeptide binding]; other site
742013007460	substrate binding pocket [chemical binding]; other site
742013007461	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
742013007462	Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618
742013007463	active site
742013007464	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
742013007465	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2828
742013007466	benzoate transport; Region: 2A0115; TIGR00895
742013007467	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
742013007468	putative substrate translocation pore; other site
742013007469	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
742013007470	Amidohydrolase; Region: Amidohydro_2; pfam04909
742013007471	hypothetical protein; Provisional; Region: PRK09262
742013007472	Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618
742013007473	2-pyrone-4,6-dicarboxylic acid (PDC) hydrolase hydrolyzes PDC to yield 4-oxalomesaconic acid (OMA) or its tautomer, 4-carboxy-2-hydroxymuconic acid (CHM). This reaction is part of the protocatechuate (PCA) 4,5-cleavage pathway. PCA is one of the most...; Region: PDC_hydrolase; cd01311
742013007474	active site
742013007475	The A subunit of Protocatechuate 4,5-dioxygenase (LigAB) is the smaller, non-catalytic subunit; Region: PCA_45_Doxase_A; cd07924
742013007476	tetramer interface [polypeptide binding]; other site
742013007477	dimer interface [polypeptide binding]; other site
742013007478	active site
742013007479	Subunit B of the Class III extradiol dioxygenase, Protocatechuate 4,5-dioxygenase, which catalyzes the oxidization and subsequent ring-opening of protocatechuate; Region: PCA_45_Dioxygenase_B; cd07364
742013007480	Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900
742013007481	active site
742013007482	Fe(II) binding site [ion binding]; other site
742013007483	dimer interface [polypeptide binding]; other site
742013007484	tetramer interface [polypeptide binding]; other site
742013007485	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
742013007486	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
742013007487	N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342
742013007488	dimer interface [polypeptide binding]; other site
742013007489	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
742013007490	active site
742013007491	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
742013007492	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
742013007493	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
742013007494	active site
742013007495	catalytic tetrad [active]
742013007496	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4994
742013007497	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
742013007498	drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710
742013007499	putative substrate translocation pore; other site
742013007500	Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958
742013007501	putative active site; other site
742013007502	catalytic residue [active]
742013007503	Predicted alternative 3-dehydroquinate synthase [Amino acid transport and metabolism]; Region: COG1465
742013007504	3-dehydroquinate synthase (EC 4.6.1.3); Region: DHQS; cl00640
742013007505	Shikimate 5-dehydrogenase [Amino acid transport and metabolism]; Region: AroE; COG0169
742013007506	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
742013007507	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
742013007508	shikimate binding site; other site
742013007509	NAD(P) binding site [chemical binding]; other site
742013007510	Transposase; Region: DEDD_Tnp_IS110; pfam01548
742013007511	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
742013007512	beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431
742013007513	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
742013007514	Bacterial transcriptional regulator; Region: IclR; pfam01614
742013007515	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
742013007516	metabolite-proton symporter; Region: 2A0106; TIGR00883
742013007517	putative substrate translocation pore; other site
742013007518	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
742013007519	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
742013007520	shikimate binding site; other site
742013007521	NAD(P) binding site [chemical binding]; other site
742013007522	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
742013007523	trimer interface [polypeptide binding]; other site
742013007524	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
742013007525	eyelet of channel; other site
742013007526	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
742013007527	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
742013007528	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
742013007529	Dehydroquinase class II; Region: DHquinase_II; pfam01220
742013007530	Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466
742013007531	trimer interface [polypeptide binding]; other site
742013007532	active site
742013007533	dimer interface [polypeptide binding]; other site
742013007534	drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710
742013007535	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
742013007536	putative substrate translocation pore; other site
742013007537	Transcriptional regulators [Transcription]; Region: GntR; COG1802
742013007538	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
742013007539	DNA-binding site [nucleotide binding]; DNA binding site
742013007540	FCD domain; Region: FCD; pfam07729
742013007541	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
742013007542	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
742013007543	hypothetical protein; Validated; Region: PRK06201
742013007544	Demethylmenaquinone methyltransferase [Coenzyme metabolism]; Region: MenG; COG0684
742013007545	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
742013007546	NAD(P) binding site [chemical binding]; other site
742013007547	Saccharopine dehydrogenase; Region: Saccharop_dh; pfam03435
742013007548	Domain of unknown function (DUF4166); Region: DUF4166; pfam13761
742013007549	Predicted thiol-disulfide oxidoreductase [General function    prediction only]; Region: COG3011
742013007550	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
742013007551	interface (dimer of trimers) [polypeptide binding]; other site
742013007552	Substrate-binding/catalytic site; other site
742013007553	Zn-binding sites [ion binding]; other site
742013007554	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
742013007555	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_2; cd08498
742013007556	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
742013007557	Transcriptional regulators RcnR and FrmR, and related domains; this domain family was previously known as part of DUF156; Region: RcnR-FrmR-like_DUF156; cd10153
742013007558	putative metal binding site [ion binding]; other site
742013007559	putative homodimer interface [polypeptide binding]; other site
742013007560	putative homotetramer interface [polypeptide binding]; other site
742013007561	putative homodimer-homodimer interface [polypeptide binding]; other site
742013007562	putative allosteric switch controlling residues; other site
742013007563	Protein of unknown function (DUF4011); Region: DUF4011; pfam13195
742013007564	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
742013007565	Walker A motif; other site
742013007566	ATP binding site [chemical binding]; other site
742013007567	Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112
742013007568	AAA domain; Region: AAA_12; pfam13087
742013007569	Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277
742013007570	putative active site [active]
742013007571	polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707
742013007572	Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598
742013007573	Mycobacterium tuberculosis CorA-like subfamily; Region: MtCorA-like; cd12830
742013007574	oligomer interface [polypeptide binding]; other site
742013007575	metal binding site [ion binding]; metal-binding site
742013007576	metal binding site [ion binding]; metal-binding site
742013007577	putative Cl binding site [ion binding]; other site
742013007578	basic sphincter; other site
742013007579	hydrophobic gate; other site
742013007580	periplasmic entrance; other site
742013007581	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
742013007582	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
742013007583	substrate binding pocket [chemical binding]; other site
742013007584	membrane-bound complex binding site; other site
742013007585	hinge residues; other site
742013007586	nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095
742013007587	FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860
742013007588	active site
742013007589	non-prolyl cis peptide bond; other site
742013007590	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
742013007591	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
742013007592	Walker A/P-loop; other site
742013007593	ATP binding site [chemical binding]; other site
742013007594	Q-loop/lid; other site
742013007595	ABC transporter signature motif; other site
742013007596	Walker B; other site
742013007597	D-loop; other site
742013007598	H-loop/switch region; other site
742013007599	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
742013007600	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
742013007601	dimer interface [polypeptide binding]; other site
742013007602	conserved gate region; other site
742013007603	putative PBP binding loops; other site
742013007604	ABC-ATPase subunit interface; other site
742013007605	NMT1/THI5 like; Region: NMT1; pfam09084
742013007606	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432
742013007607	substrate binding pocket [chemical binding]; other site
742013007608	membrane-bound complex binding site; other site
742013007609	NIPSNAP; Region: NIPSNAP; pfam07978
742013007610	Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049
742013007611	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
742013007612	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
742013007613	dimer interface [polypeptide binding]; other site
742013007614	putative CheW interface [polypeptide binding]; other site
742013007615	Uncharacterized conserved protein (DUF2132); Region: DUF2132; pfam09905
742013007616	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
742013007617	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
742013007618	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
742013007619	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
742013007620	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
742013007621	RsbT co-antagonist protein rsbRD N-terminal domain; Region: RsbRD_N; pfam14361
742013007622	Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041
742013007623	Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041
742013007624	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
742013007625	Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172
742013007626	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
742013007627	dimer interface [polypeptide binding]; other site
742013007628	phosphorylation site [posttranslational modification]
742013007629	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
742013007630	ATP binding site [chemical binding]; other site
742013007631	Mg2+ binding site [ion binding]; other site
742013007632	G-X-G motif; other site
742013007633	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
742013007634	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
742013007635	active site
742013007636	phosphorylation site [posttranslational modification]
742013007637	intermolecular recognition site; other site
742013007638	dimerization interface [polypeptide binding]; other site
742013007639	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
742013007640	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
742013007641	putative active site [active]
742013007642	heme pocket [chemical binding]; other site
742013007643	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
742013007644	dimer interface [polypeptide binding]; other site
742013007645	phosphorylation site [posttranslational modification]
742013007646	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
742013007647	ATP binding site [chemical binding]; other site
742013007648	Mg2+ binding site [ion binding]; other site
742013007649	G-X-G motif; other site
742013007650	Response regulator receiver domain; Region: Response_reg; pfam00072
742013007651	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
742013007652	active site
742013007653	phosphorylation site [posttranslational modification]
742013007654	intermolecular recognition site; other site
742013007655	dimerization interface [polypeptide binding]; other site
742013007656	Transcriptional regulator [Transcription]; Region: LysR; COG0583
742013007657	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
742013007658	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
742013007659	dimerization interface [polypeptide binding]; other site
742013007660	PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276
742013007661	putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824
742013007662	NAD(P) binding site [chemical binding]; other site
742013007663	Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329
742013007664	putative addiction module antidote protein, CC2985 family; Region: antidote_CC2985; TIGR02606
742013007665	Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016
742013007666	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
742013007667	Major Facilitator Superfamily; Region: MFS_1; pfam07690
742013007668	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
742013007669	putative substrate translocation pore; other site
742013007670	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
742013007671	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
742013007672	dimerization interface [polypeptide binding]; other site
742013007673	Cytochrome c; Region: Cytochrom_C; cl11414
742013007674	Cytochrome c; Region: Cytochrom_C; pfam00034
742013007675	PRC-barrel domain; Region: PRC; pfam05239
742013007676	Predicted membrane protein [Function unknown]; Region: COG1971
742013007677	Domain of unknown function DUF; Region: DUF204; pfam02659
742013007678	Domain of unknown function DUF; Region: DUF204; pfam02659
742013007679	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
742013007680	GAF domain; Region: GAF; pfam01590
742013007681	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
742013007682	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
742013007683	metal binding site [ion binding]; metal-binding site
742013007684	active site
742013007685	I-site; other site
742013007686	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
742013007687	Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409
742013007688	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cd00838
742013007689	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
742013007690	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
742013007691	putative active site [active]
742013007692	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
742013007693	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
742013007694	metal binding site [ion binding]; metal-binding site
742013007695	active site
742013007696	I-site; other site
742013007697	Transcriptional regulator [Transcription]; Region: LysR; COG0583
742013007698	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
742013007699	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_1; cd08460
742013007700	putative substrate binding pocket [chemical binding]; other site
742013007701	putative dimerization interface [polypeptide binding]; other site
742013007702	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
742013007703	Major Facilitator Superfamily; Region: MFS_1; pfam07690
742013007704	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
742013007705	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
742013007706	dimer interface [polypeptide binding]; other site
742013007707	conserved gate region; other site
742013007708	putative PBP binding loops; other site
742013007709	ABC-ATPase subunit interface; other site
742013007710	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
742013007711	dimer interface [polypeptide binding]; other site
742013007712	conserved gate region; other site
742013007713	putative PBP binding loops; other site
742013007714	ABC-ATPase subunit interface; other site
742013007715	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
742013007716	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
742013007717	substrate binding pocket [chemical binding]; other site
742013007718	membrane-bound complex binding site; other site
742013007719	hinge residues; other site
742013007720	hypothetical protein; Provisional; Region: PRK07538
742013007721	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
742013007722	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
742013007723	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
742013007724	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
742013007725	alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289
742013007726	putative NAD(P) binding site [chemical binding]; other site
742013007727	short chain dehydrogenase; Validated; Region: PRK08264
742013007728	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
742013007729	NAD(P) binding site [chemical binding]; other site
742013007730	active site
742013007731	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
742013007732	dimerization interface [polypeptide binding]; other site
742013007733	putative DNA binding site [nucleotide binding]; other site
742013007734	putative Zn2+ binding site [ion binding]; other site
742013007735	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
742013007736	Low molecular weight phosphatase family; Region: LMWPc; cd00115
742013007737	active site
742013007738	arsenical pump membrane protein; Provisional; Region: PRK15445
742013007739	Anion permease ArsB.  These permeases have been shown to export arsenate and antimonite in eubacteria and archaea.  A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118
742013007740	transmembrane helices; other site
742013007741	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
742013007742	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
742013007743	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
742013007744	Esterase PHB depolymerase; Region: Esterase_phd; pfam10503
742013007745	Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain [Transcription]; Region: COG3609
742013007746	Haemolysin-III related; Region: HlyIII; cl03831
742013007747	channel protein, hemolysin III family; Region: hlyIII; TIGR01065
742013007748	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
742013007749	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
742013007750	ligand binding site [chemical binding]; other site
742013007751	flexible hinge region; other site
742013007752	Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545
742013007753	Putative glucoamylase; Region: Glycoamylase; pfam10091
742013007754	Second GH94N domain of cyclic beta 1-2 glucan synthetase and similar domains; Region: GH94N_ChvB_NdvB_2_like; cd11753
742013007755	Cellobiose phosphorylase [Carbohydrate transport and metabolism]; Region: COG3459
742013007756	N-terminal domain of glycoside hydrolase family 94 and related domains; Region: GH94N_like; cl17067
742013007757	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
742013007758	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
742013007759	metal binding site [ion binding]; metal-binding site
742013007760	active site
742013007761	I-site; other site
742013007762	Protein of unknown function (DUF3309); Region: DUF3309; pfam11752
742013007763	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
742013007764	Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027
742013007765	Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545
742013007766	putative switch regulator; other site
742013007767	non-specific DNA interactions [nucleotide binding]; other site
742013007768	DNA binding site [nucleotide binding]
742013007769	sequence specific DNA binding site [nucleotide binding]; other site
742013007770	putative cAMP binding site [chemical binding]; other site
742013007771	Uncharacterized conserved protein [Function unknown]; Region: COG3791
742013007772	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
742013007773	phosphopeptide binding site; other site
742013007774	bacteriocin biosynthesis cyclodehydratase domain; Region: cyclo_dehyd_2; TIGR03882
742013007775	YcaO-like family; Region: YcaO; pfam02624
742013007776	thiazole/oxazole-forming peptide maturase, SagD family component; Region: TOMM_cyclo_SagD; TIGR03604
742013007777	Leucine carboxyl methyltransferase; Region: LCM; pfam04072
742013007778	ribosomal natural product, two-chain TOMM family; Region: RNP_Burkhold; TIGR03795
742013007779	ribosomal natural product, two-chain TOMM family; Region: RNP_Burkhold; TIGR03795
742013007780	Catalytic domain of Protein Kinases; Region: PKc; cd00180
742013007781	active site
742013007782	ATP binding site [chemical binding]; other site
742013007783	substrate binding site [chemical binding]; other site
742013007784	TOMM system kinase/cyclase fusion protein; Region: TOMM_kin_cyc; TIGR03903
742013007785	activation loop (A-loop); other site
742013007786	cyclase homology domain; Region: CHD; cd07302
742013007787	dimer interface [polypeptide binding]; other site
742013007788	nucleotidyl binding site; other site
742013007789	metal binding site [ion binding]; metal-binding site
742013007790	AAA ATPase domain; Region: AAA_16; pfam13191
742013007791	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
742013007792	binding surface
742013007793	TPR motif; other site
742013007794	Low molecular weight phosphatase family; Region: LMWPc; cl00105
742013007795	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
742013007796	active site
742013007797	Uncharacterized conserved protein [Function unknown]; Region: COG3791
742013007798	Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616
742013007799	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Low Specificity D-Threonine Aldolase; Region: PLPDE_III_LS_D-TA; cd06819
742013007800	dimer interface [polypeptide binding]; other site
742013007801	active site
742013007802	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
742013007803	substrate binding site [chemical binding]; other site
742013007804	catalytic residue [active]
742013007805	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
742013007806	Transcriptional regulator [Transcription]; Region: LysR; COG0583
742013007807	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
742013007808	The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433
742013007809	putative dimerization interface [polypeptide binding]; other site
742013007810	beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431
742013007811	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
742013007812	Bacterial transcriptional regulator; Region: IclR; pfam01614
742013007813	4-hydroxybenzoate 3-monooxygenase; Validated; Region: PRK08243
742013007814	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
742013007815	Biofilm formation and stress response factor; Region: BsmA; pfam10014
742013007816	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
742013007817	Ligand Binding Site [chemical binding]; other site
742013007818	Hemerythrin; Region: Hemerythrin; cd12107
742013007819	Fe binding site [ion binding]; other site
742013007820	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
742013007821	allantoate amidohydrolase; Reviewed; Region: PRK12890
742013007822	M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884
742013007823	active site
742013007824	metal binding site [ion binding]; metal-binding site
742013007825	dimer interface [polypeptide binding]; other site
742013007826	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
742013007827	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
742013007828	dimer interface [polypeptide binding]; other site
742013007829	phosphorylation site [posttranslational modification]
742013007830	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
742013007831	ATP binding site [chemical binding]; other site
742013007832	Mg2+ binding site [ion binding]; other site
742013007833	G-X-G motif; other site
742013007834	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
742013007835	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
742013007836	active site
742013007837	phosphorylation site [posttranslational modification]
742013007838	intermolecular recognition site; other site
742013007839	dimerization interface [polypeptide binding]; other site
742013007840	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
742013007841	Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086
742013007842	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
742013007843	dimer interface [polypeptide binding]; other site
742013007844	phosphorylation site [posttranslational modification]
742013007845	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
742013007846	ATP binding site [chemical binding]; other site
742013007847	Mg2+ binding site [ion binding]; other site
742013007848	G-X-G motif; other site
742013007849	Response regulator receiver domain; Region: Response_reg; pfam00072
742013007850	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
742013007851	active site
742013007852	phosphorylation site [posttranslational modification]
742013007853	intermolecular recognition site; other site
742013007854	dimerization interface [polypeptide binding]; other site
742013007855	RNA polymerase factor sigma-54; Reviewed; Region: PRK05932
742013007856	Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309
742013007857	Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963
742013007858	Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552
742013007859	histidine kinase; Provisional; Region: PRK13557
742013007860	Predicted membrane protein [Function unknown]; Region: COG2261
742013007861	Response regulator receiver domain; Region: Response_reg; pfam00072
742013007862	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
742013007863	active site
742013007864	phosphorylation site [posttranslational modification]
742013007865	intermolecular recognition site; other site
742013007866	dimerization interface [polypeptide binding]; other site
742013007867	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
742013007868	Walker A motif; other site
742013007869	ATP binding site [chemical binding]; other site
742013007870	Walker B motif; other site
742013007871	arginine finger; other site
742013007872	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
742013007873	Topoisomerase IB [DNA replication, recombination, and repair]; Region: COG3569
742013007874	DNA topoisomerase IB, C-terminal catalytic domain. Topoisomerase I promotes the relaxation of both positive and negative DNA superhelical tension by introducing a transient single-stranded break in duplex DNA. This function is vital for the processes of...; Region: Topo_IB_C; cd00659
742013007875	active site
742013007876	DNA binding site [nucleotide binding]
742013007877	Int/Topo IB signature motif; other site
742013007878	catalytic residues [active]
742013007879	hydroperoxidase II; Provisional; Region: katE; PRK11249
742013007880	Clade 2 of the heme-binding enzyme catalase; Region: catalase_clade_2; cd08155
742013007881	tetramer interface [polypeptide binding]; other site
742013007882	heme binding pocket [chemical binding]; other site
742013007883	Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132
742013007884	domain interactions; other site
742013007885	Ku protein, prokaryotic; Region: Ku_bact; TIGR02772
742013007886	Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789
742013007887	putative homodimer interface [polypeptide binding]; other site
742013007888	putative DNA binding site [nucleotide binding]; other site
742013007889	ATP-dependent DNA ligase; Reviewed; Region: ligD; PRK05972
742013007890	DNA ligase D, 3'-phosphoesterase domain; Region: LigD_PE_dom; TIGR02777
742013007891	Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906
742013007892	active site
742013007893	DNA binding site [nucleotide binding]
742013007894	The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971
742013007895	DNA binding site [nucleotide binding]
742013007896	PaeLigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for...; Region: PaeLigD_Pol_like; cd04862
742013007897	nucleotide binding site [chemical binding]; other site
742013007898	short chain dehydrogenase; Provisional; Region: PRK07023
742013007899	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
742013007900	NAD(P) binding site [chemical binding]; other site
742013007901	active site
742013007902	Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate  (PLP), by catalyzing the phosphorylation of the precursor vitamin B6  in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173
742013007903	dimer interface [polypeptide binding]; other site
742013007904	pyridoxamine kinase; Validated; Region: PRK05756
742013007905	pyridoxal binding site [chemical binding]; other site
742013007906	ATP binding site [chemical binding]; other site
742013007907	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
742013007908	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
742013007909	Walker A/P-loop; other site
742013007910	ATP binding site [chemical binding]; other site
742013007911	Q-loop/lid; other site
742013007912	ABC transporter signature motif; other site
742013007913	Walker B; other site
742013007914	D-loop; other site
742013007915	H-loop/switch region; other site
742013007916	leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livG; PRK11300
742013007917	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
742013007918	Walker A/P-loop; other site
742013007919	ATP binding site [chemical binding]; other site
742013007920	Q-loop/lid; other site
742013007921	ABC transporter signature motif; other site
742013007922	Walker B; other site
742013007923	D-loop; other site
742013007924	H-loop/switch region; other site
742013007925	leucine/isoleucine/valine transporter permease subunit; Provisional; Region: livM; PRK11301
742013007926	Domain of unknown function (DUF3382); Region: DUF3382; pfam11862
742013007927	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
742013007928	TM-ABC transporter signature motif; other site
742013007929	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
742013007930	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
742013007931	TM-ABC transporter signature motif; other site
742013007932	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
742013007933	Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342
742013007934	dimerization interface [polypeptide binding]; other site
742013007935	ligand binding site [chemical binding]; other site
742013007936	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
742013007937	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
742013007938	active site
742013007939	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
742013007940	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
742013007941	putative active site [active]
742013007942	heme pocket [chemical binding]; other site
742013007943	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
742013007944	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
742013007945	putative active site [active]
742013007946	heme pocket [chemical binding]; other site
742013007947	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
742013007948	dimer interface [polypeptide binding]; other site
742013007949	phosphorylation site [posttranslational modification]
742013007950	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
742013007951	ATP binding site [chemical binding]; other site
742013007952	Mg2+ binding site [ion binding]; other site
742013007953	G-X-G motif; other site
742013007954	Response regulator receiver domain; Region: Response_reg; pfam00072
742013007955	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
742013007956	active site
742013007957	phosphorylation site [posttranslational modification]
742013007958	intermolecular recognition site; other site
742013007959	dimerization interface [polypeptide binding]; other site
742013007960	glycine dehydrogenase; Provisional; Region: PRK05367
742013007961	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
742013007962	tetramer interface [polypeptide binding]; other site
742013007963	pyridoxal 5'-phosphate binding site [chemical binding]; other site
742013007964	catalytic residue [active]
742013007965	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
742013007966	tetramer interface [polypeptide binding]; other site
742013007967	pyridoxal 5'-phosphate binding site [chemical binding]; other site
742013007968	catalytic residue [active]
742013007969	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
742013007970	lipoyl attachment site [posttranslational modification]; other site
742013007971	glycine cleavage system aminomethyltransferase T; Provisional; Region: gcvT; PRK13579
742013007972	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
742013007973	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187
742013007974	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
742013007975	Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929
742013007976	acyl-activating enzyme (AAE) consensus motif; other site
742013007977	putative AMP binding site [chemical binding]; other site
742013007978	putative active site [active]
742013007979	putative CoA binding site [chemical binding]; other site
742013007980	Transcriptional regulator [Transcription]; Region: LysR; COG0583
742013007981	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
742013007982	The C-terminal substrate binding domain of LysR-type transcriptional regulator ToxR regulates the expression of the toxoflavin biosynthesis genes; contains the type 2 periplasmic bindinig fold; Region: PBP2_ToxR; cd08465
742013007983	putative substrate binding pocket [chemical binding]; other site
742013007984	putative dimerization interface [polypeptide binding]; other site
742013007985	Protein of unknown function, DUF606; Region: DUF606; pfam04657
742013007986	7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695
742013007987	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
742013007988	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
742013007989	dimer interface [polypeptide binding]; other site
742013007990	phosphorylation site [posttranslational modification]
742013007991	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
742013007992	ATP binding site [chemical binding]; other site
742013007993	Mg2+ binding site [ion binding]; other site
742013007994	G-X-G motif; other site
742013007995	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
742013007996	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
742013007997	putative DNA binding site [nucleotide binding]; other site
742013007998	putative Zn2+ binding site [ion binding]; other site
742013007999	AsnC family; Region: AsnC_trans_reg; pfam01037
742013008000	Helix-turn-helix domain; Region: HTH_18; pfam12833
742013008001	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
742013008002	N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247
742013008003	lysine transporter; Provisional; Region: PRK10836
742013008004	Transcriptional regulator [Transcription]; Region: LysR; COG0583
742013008005	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
742013008006	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
742013008007	putative effector binding pocket; other site
742013008008	dimerization interface [polypeptide binding]; other site
742013008009	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
742013008010	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
742013008011	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
742013008012	Helix-turn-helix domain; Region: HTH_18; pfam12833
742013008013	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
742013008014	Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662
742013008015	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101
742013008016	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
742013008017	Walker A/P-loop; other site
742013008018	ATP binding site [chemical binding]; other site
742013008019	Q-loop/lid; other site
742013008020	ABC transporter signature motif; other site
742013008021	Walker B; other site
742013008022	D-loop; other site
742013008023	H-loop/switch region; other site
742013008024	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
742013008025	Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574
742013008026	TM-ABC transporter signature motif; other site
742013008027	Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325
742013008028	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
742013008029	zinc binding site [ion binding]; other site
742013008030	putative ligand binding site [chemical binding]; other site
742013008031	Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644
742013008032	Electron transfer flavoprotein-ubiquinone oxidoreductase; Region: ETF_QO; pfam05187
742013008033	Ferredoxin-like protein [Energy production and conversion]; Region: FixX; COG2440
742013008034	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
742013008035	active site
742013008036	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
742013008037	active site
742013008038	catalytic triad [active]
742013008039	oxyanion hole [active]
742013008040	Transcriptional regulators [Transcription]; Region: PurR; COG1609
742013008041	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
742013008042	DNA binding site [nucleotide binding]
742013008043	domain linker motif; other site
742013008044	Ligand-binding domain of MalI, a transcription regulator of the maltose system of Escherichia coli and its close homologs from other bacteria; Region: PBP1_MalI_like; cd06289
742013008045	putative dimerization interface [polypeptide binding]; other site
742013008046	putative ligand binding site [chemical binding]; other site
742013008047	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
742013008048	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
742013008049	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
742013008050	Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism]; Region: COG4670
742013008051	Coenzyme A transferase; Region: CoA_trans; smart00882
742013008052	Coenzyme A transferase; Region: CoA_trans; cl17247
742013008053	enoyl-CoA hydratase; Provisional; Region: PRK07657
742013008054	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
742013008055	substrate binding site [chemical binding]; other site
742013008056	oxyanion hole (OAH) forming residues; other site
742013008057	trimer interface [polypeptide binding]; other site
742013008058	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
742013008059	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
742013008060	NAD(P) binding site [chemical binding]; other site
742013008061	catalytic residues [active]
742013008062	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
742013008063	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
742013008064	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
742013008065	dimer interface [polypeptide binding]; other site
742013008066	conserved gate region; other site
742013008067	putative PBP binding loops; other site
742013008068	ABC-ATPase subunit interface; other site
742013008069	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
742013008070	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
742013008071	dimer interface [polypeptide binding]; other site
742013008072	conserved gate region; other site
742013008073	putative PBP binding loops; other site
742013008074	ABC-ATPase subunit interface; other site
742013008075	ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839
742013008076	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
742013008077	Walker A/P-loop; other site
742013008078	ATP binding site [chemical binding]; other site
742013008079	Q-loop/lid; other site
742013008080	ABC transporter signature motif; other site
742013008081	Walker B; other site
742013008082	D-loop; other site
742013008083	H-loop/switch region; other site
742013008084	TOBE domain; Region: TOBE; pfam03459
742013008085	Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303
742013008086	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
742013008087	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: PRK12745
742013008088	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
742013008089	NAD(P) binding site [chemical binding]; other site
742013008090	active site
742013008091	choline dehydrogenase; Validated; Region: PRK02106
742013008092	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
742013008093	Protein of unknown function (DUF993); Region: DUF993; pfam06187
742013008094	N-acetyl-gamma-glutamyl-phosphate reductase; Provisional; Region: PRK11863
742013008095	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
742013008096	Transcriptional regulator [Transcription]; Region: LysR; COG0583
742013008097	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
742013008098	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
742013008099	dimerization interface [polypeptide binding]; other site
742013008100	Transcriptional regulator [Transcription]; Region: LysR; COG0583
742013008101	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
742013008102	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
742013008103	putative effector binding pocket; other site
742013008104	dimerization interface [polypeptide binding]; other site
742013008105	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
742013008106	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
742013008107	active site
742013008108	catalytic tetrad [active]
742013008109	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
742013008110	Major Facilitator Superfamily; Region: MFS_1; pfam07690
742013008111	putative substrate translocation pore; other site
742013008112	Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917
742013008113	Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599
742013008114	Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599
742013008115	Uncharacterized enzymes similar to novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like-3; cd12810
742013008116	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
742013008117	catalytic site [active]
742013008118	Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073
742013008119	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
742013008120	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
742013008121	NAD(P) binding site [chemical binding]; other site
742013008122	active site
742013008123	Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141
742013008124	Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693
742013008125	potential catalytic triad [active]
742013008126	conserved cys residue [active]
742013008127	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
742013008128	Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044
742013008129	DNA binding residues [nucleotide binding]
742013008130	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263
742013008131	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
742013008132	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
742013008133	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
742013008134	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
742013008135	Domain of unknown function (DUF4337); Region: DUF4337; pfam14235
742013008136	Uncharacterized protein conserved in bacteria (DUF2256); Region: DUF2256; pfam10013
742013008137	Predicted NAD/FAD-dependent oxidoreductase [General function prediction only]; Region: COG3380
742013008138	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
742013008139	Lipocalin-like domain; Region: Lipocalin_2; pfam08212
742013008140	Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104
742013008141	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
742013008142	DNA binding residues [nucleotide binding]
742013008143	B12 binding domain; Region: B12-binding_2; pfam02607
742013008144	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
742013008145	B12 binding site [chemical binding]; other site
742013008146	CHASE3 domain; Region: CHASE3; pfam05227
742013008147	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
742013008148	dimerization interface [polypeptide binding]; other site
742013008149	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
742013008150	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
742013008151	dimer interface [polypeptide binding]; other site
742013008152	putative CheW interface [polypeptide binding]; other site
742013008153	Dyp-type peroxidase family; Region: Dyp_perox; cl01067
742013008154	Pyruvate formate lyase; Region: PFL; pfam02901
742013008155	Sodium:dicarboxylate symporter family; Region: SDF; cl00573
742013008156	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
742013008157	Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191
742013008158	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
742013008159	dimer interface [polypeptide binding]; other site
742013008160	phosphorylation site [posttranslational modification]
742013008161	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
742013008162	ATP binding site [chemical binding]; other site
742013008163	Mg2+ binding site [ion binding]; other site
742013008164	G-X-G motif; other site
742013008165	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
742013008166	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
742013008167	active site
742013008168	phosphorylation site [posttranslational modification]
742013008169	intermolecular recognition site; other site
742013008170	dimerization interface [polypeptide binding]; other site
742013008171	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
742013008172	Walker A motif; other site
742013008173	ATP binding site [chemical binding]; other site
742013008174	Walker B motif; other site
742013008175	arginine finger; other site
742013008176	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
742013008177	Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316
742013008178	L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948
742013008179	active site pocket [active]
742013008180	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
742013008181	Transcriptional regulators [Transcription]; Region: PurR; COG1609
742013008182	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
742013008183	DNA binding site [nucleotide binding]
742013008184	domain linker motif; other site
742013008185	Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575
742013008186	putative dimerization interface [polypeptide binding]; other site
742013008187	putative ligand binding site [chemical binding]; other site
742013008188	N-acetyltransferase; Region: Acetyltransf_2; pfam00797
742013008189	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
742013008190	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
742013008191	DNA-binding site [nucleotide binding]; DNA binding site
742013008192	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
742013008193	pyridoxal 5'-phosphate binding site [chemical binding]; other site
742013008194	homodimer interface [polypeptide binding]; other site
742013008195	catalytic residue [active]
742013008196	uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926
742013008197	Carboxymuconolactone decarboxylase family; Region: CMD; cl00460
742013008198	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
742013008199	transcriptional activator TtdR; Provisional; Region: PRK09801
742013008200	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
742013008201	dimerization interface [polypeptide binding]; other site
742013008202	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
742013008203	Bacterial protein of unknown function (DUF945); Region: DUF945; pfam06097
742013008204	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5339
742013008205	Transcriptional regulator [Transcription]; Region: IclR; COG1414
742013008206	IclR helix-turn-helix domain; Region: HTH_IclR; cl17605
742013008207	Bacterial transcriptional regulator; Region: IclR; pfam01614
742013008208	ABC-type amino acid transport/signal transduction systems, periplasmic component/domain [Amino acid transport and metabolism / Signal transduction mechanisms]; Region: HisJ; COG0834
742013008209	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
742013008210	membrane-bound complex binding site; other site
742013008211	hinge residues; other site
742013008212	hypothetical protein; Validated; Region: PRK06201
742013008213	Demethylmenaquinone methyltransferase [Coenzyme metabolism]; Region: MenG; COG0684
742013008214	D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain; Region: 2-Hacid_dh; pfam00389
742013008215	Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173
742013008216	ligand binding site [chemical binding]; other site
742013008217	NAD binding site [chemical binding]; other site
742013008218	dimerization interface [polypeptide binding]; other site
742013008219	catalytic site [active]
742013008220	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
742013008221	Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618
742013008222	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
742013008223	active site
742013008224	SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450
742013008225	Predicted transcriptional regulators [Transcription]; Region: COG1695
742013008226	Transcriptional regulator PadR-like family; Region: PadR; cl17335
742013008227	Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400
742013008228	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
742013008229	2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli  is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930
742013008230	active site
742013008231	FMN binding site [chemical binding]; other site
742013008232	2,4-decadienoyl-CoA binding site; other site
742013008233	catalytic residue [active]
742013008234	4Fe-4S cluster binding site [ion binding]; other site
742013008235	Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446
742013008236	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
742013008237	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
742013008238	Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753
742013008239	Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156
742013008240	tetramer interface [polypeptide binding]; other site
742013008241	heme binding pocket [chemical binding]; other site
742013008242	NADPH binding site [chemical binding]; other site
742013008243	PAS domain; Region: PAS_9; pfam13426
742013008244	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
742013008245	putative active site [active]
742013008246	heme pocket [chemical binding]; other site
742013008247	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
742013008248	DNA binding residues [nucleotide binding]
742013008249	dimerization interface [polypeptide binding]; other site
742013008250	Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788
742013008251	3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428
742013008252	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
742013008253	Zn2+ binding site [ion binding]; other site
742013008254	Mg2+ binding site [ion binding]; other site
742013008255	Uncharacterized conserved protein [Function unknown]; Region: COG4544
742013008256	Y-family of DNA polymerases; Region: PolY; cl12025
742013008257	DNA binding site [nucleotide binding]
742013008258	error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672
742013008259	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at DnaE2 gene; Region: PHP_PolIIIA_DnaE2; cd07434
742013008260	putative active site [active]
742013008261	putative PHP Thumb interface [polypeptide binding]; other site
742013008262	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
742013008263	generic binding surface II; other site
742013008264	generic binding surface I; other site
742013008265	Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281
742013008266	homodimer interaction site [polypeptide binding]; other site
742013008267	cofactor binding site; other site
742013008268	N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; cl17549
742013008269	Uncharacterized protein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: AsmA; COG2982
742013008270	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
742013008271	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
742013008272	D-galactonate transporter; Region: 2A0114; TIGR00893
742013008273	putative substrate translocation pore; other site
742013008274	benzoate transport; Region: 2A0115; TIGR00895
742013008275	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
742013008276	putative substrate translocation pore; other site
742013008277	SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450
742013008278	Prokaryotic protein of unknown function (DUF849); Region: DUF849; pfam05853
742013008279	short chain dehydrogenase; Provisional; Region: PRK12829
742013008280	classical (c) SDRs; Region: SDR_c; cd05233
742013008281	NAD(P) binding site [chemical binding]; other site
742013008282	active site
742013008283	Transcriptional regulators [Transcription]; Region: GntR; COG1802
742013008284	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
742013008285	DNA-binding site [nucleotide binding]; DNA binding site
742013008286	FCD domain; Region: FCD; pfam07729
742013008287	PIN domain; Region: PIN_3; cl17397
742013008288	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
742013008289	Pseudouridine synthase, a subgroup of the RluA family; Region: PSRA_1; cd02558
742013008290	probable active site [active]
742013008291	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
742013008292	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
742013008293	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
742013008294	Major Facilitator Superfamily; Region: MFS_1; pfam07690
742013008295	putative substrate translocation pore; other site
742013008296	efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998
742013008297	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
742013008298	HlyD family secretion protein; Region: HlyD_3; pfam13437
742013008299	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
742013008300	tetrathionate reductase subunit A; Provisional; Region: PRK14991
742013008301	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
742013008302	molybdopterin cofactor binding site; other site
742013008303	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
742013008304	This CD contains the molybdopterin_binding C-terminal (MopB_CT) region of tetrathionate reductase, subunit A, (TtrA); respiratory arsenate As(V) reductase, catalytic subunit (ArrA); and other related proteins; Region: MopB_CT_Tetrathionate_Arsenate-R; cd02780
742013008305	putative molybdopterin cofactor binding site; other site
742013008306	tetrathionate reductase subunit C; Provisional; Region: PRK14992
742013008307	Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437
742013008308	4Fe-4S binding domain; Region: Fer4; pfam00037
742013008309	DsrE/DsrF-like family; Region: DrsE; cl00672
742013008310	disulfide isomerase/thiol-disulfide oxidase; Provisional; Region: dsbG; PRK11657
742013008311	DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020
742013008312	dimerization domain [polypeptide binding]; other site
742013008313	dimer interface [polypeptide binding]; other site
742013008314	catalytic residues [active]
742013008315	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
742013008316	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
742013008317	catalytic residues [active]
742013008318	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
742013008319	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
742013008320	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
742013008321	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
742013008322	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
742013008323	active site
742013008324	phosphorylation site [posttranslational modification]
742013008325	intermolecular recognition site; other site
742013008326	dimerization interface [polypeptide binding]; other site
742013008327	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
742013008328	DNA binding site [nucleotide binding]
742013008329	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
742013008330	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
742013008331	dimer interface [polypeptide binding]; other site
742013008332	phosphorylation site [posttranslational modification]
742013008333	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
742013008334	ATP binding site [chemical binding]; other site
742013008335	Mg2+ binding site [ion binding]; other site
742013008336	G-X-G motif; other site
742013008337	Cytochrome c; Region: Cytochrom_C; cl11414
742013008338	Cytochrome c; Region: Cytochrom_C; cl11414
742013008339	Cytochrome c [Energy production and conversion]; Region: COG3258
742013008340	Cytochrome c; Region: Cytochrom_C; pfam00034
742013008341	Uncharacterized protein conserved in bacteria (DUF2325); Region: DUF2325; pfam10087
742013008342	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
742013008343	metal binding site 2 [ion binding]; metal-binding site
742013008344	putative DNA binding helix; other site
742013008345	metal binding site 1 [ion binding]; metal-binding site
742013008346	dimer interface [polypeptide binding]; other site
742013008347	structural Zn2+ binding site [ion binding]; other site
742013008348	Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135
742013008349	putative FMN binding site [chemical binding]; other site
742013008350	O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315
742013008351	Leucine carboxyl methyltransferase; Region: LCM; pfam04072
742013008352	Leucine carboxyl methyltransferase; Region: LCM; cl01306
742013008353	Isochorismatase family; Region: Isochorismatase; pfam00857
742013008354	Nicotinamidase_ related amidohydrolases.  Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014
742013008355	catalytic triad [active]
742013008356	conserved cis-peptide bond; other site
742013008357	Domain of unknown function DUF21; Region: DUF21; pfam01595
742013008358	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
742013008359	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
742013008360	Transporter associated domain; Region: CorC_HlyC; smart01091
742013008361	azurin; Region: azurin; TIGR02695
742013008362	Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain [General function prediction only]; Region: COG2872
742013008363	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
742013008364	Domain of unknown function (DUF4132); Region: DUF4132; pfam13569
742013008365	Domain of unknown function (DUF4132); Region: DUF4132; pfam13569
742013008366	Domain of unknown function (DUF4132); Region: DUF4132; pfam13569
742013008367	MoxR-like ATPases [General function prediction only]; Region: COG0714
742013008368	AAA domain (dynein-related subfamily); Region: AAA_5; pfam07728
742013008369	VWA domain containing CoxE-like protein; Region: VWA_CoxE; pfam05762
742013008370	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
742013008371	metal ion-dependent adhesion site (MIDAS); other site
742013008372	Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714
742013008373	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
742013008374	tetramer interface [polypeptide binding]; other site
742013008375	active site
742013008376	Mg2+/Mn2+ binding site [ion binding]; other site
742013008377	Protein of unknown function (DUF1501); Region: DUF1501; pfam07394
742013008378	Protein of unknown function (DUF1800); Region: DUF1800; pfam08811
742013008379	Heavy-metal resistance; Region: Metal_resist; pfam13801
742013008380	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
742013008381	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
742013008382	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
742013008383	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
742013008384	active site
742013008385	DNA binding site [nucleotide binding]
742013008386	Int/Topo IB signature motif; other site
742013008387	Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; cl17523
742013008388	HNH endonuclease; Region: HNH_2; pfam13391
742013008389	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
742013008390	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
742013008391	DNA methylase; Region: N6_N4_Mtase; pfam01555
742013008392	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
742013008393	Sensors of blue-light using FAD; Region: BLUF; pfam04940
742013008394	H-NS histone family; Region: Histone_HNS; pfam00816
742013008395	Domain in histone-like proteins of HNS family; Region: HNS; smart00528
742013008396	potassium transporter; Provisional; Region: PLN00149
742013008397	RecT family; Region: RecT; cl04285
742013008398	YqaJ-like viral recombinase domain; Region: YqaJ; pfam09588
742013008399	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
742013008400	Excalibur calcium-binding domain; Region: Excalibur; pfam05901
742013008401	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
742013008402	Catalytic site [active]
742013008403	glycoprotein BALF4; Provisional; Region: PHA03231
742013008404	replicative DNA helicase; Region: DnaB; TIGR00665
742013008405	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
742013008406	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
742013008407	Walker A motif; other site
742013008408	ATP binding site [chemical binding]; other site
742013008409	Walker B motif; other site
742013008410	DNA binding loops [nucleotide binding]
742013008411	Endodeoxyribonuclease RusA; Region: RusA; pfam05866
742013008412	NinB protein; Region: NinB; pfam05772
742013008413	TIR domain; Region: TIR_2; pfam13676
742013008414	Phage terminase large subunit; Region: Terminase_3; cl12054
742013008415	Terminase-like family; Region: Terminase_6; pfam03237
742013008416	H-NS histone family; Region: Histone_HNS; pfam00816
742013008417	Domain in histone-like proteins of HNS family; Region: HNS; smart00528
742013008418	BNR repeat-like domain; Region: BNR_2; pfam13088
742013008419	Phage-related tail fibre protein [General function prediction only]; Region: COG5301
742013008420	lysozyme_like domain.  This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222
742013008421	catalytic residue [active]
742013008422	Bacterial SH3 domain; Region: SH3_3; cl17532
742013008423	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
742013008424	Isochorismatase family; Region: Isochorismatase; pfam00857
742013008425	catalytic triad [active]
742013008426	conserved cis-peptide bond; other site
742013008427	Predicted membrane protein [Function unknown]; Region: COG2323
742013008428	HNH endonuclease; Region: HNH_3; pfam13392
742013008429	AP2 domain; Region: AP2; pfam00847
742013008430	Uncharacterized ACR, COG2135; Region: DUF159; pfam02586
742013008431	Putative hemolysin [General function prediction only]; Region: Hlx; COG3042
742013008432	Domain of unknown function (DUF333); Region: DUF333; pfam03891
742013008433	H-NS histone family; Region: Histone_HNS; pfam00816
742013008434	Domain in histone-like proteins of HNS family; Region: HNS; smart00528
742013008435	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
742013008436	S-adenosylmethionine binding site [chemical binding]; other site
742013008437	Flagellar basal body-associated protein FliL; Region: FliL; cl00681
742013008438	Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612
742013008439	Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628
742013008440	protoheme IX farnesyltransferase; Provisional; Region: PRK04375
742013008441	UbiA prenyltransferase family; Region: UbiA; pfam01040
742013008442	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain [Signal transduction mechanisms / Transcription]; Region: COG4567
742013008443	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
742013008444	active site
742013008445	phosphorylation site [posttranslational modification]
742013008446	intermolecular recognition site; other site
742013008447	dimerization interface [polypeptide binding]; other site
742013008448	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
742013008449	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
742013008450	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080
742013008451	dimer interface [polypeptide binding]; other site
742013008452	phosphorylation site [posttranslational modification]
742013008453	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
742013008454	ATP binding site [chemical binding]; other site
742013008455	Mg2+ binding site [ion binding]; other site
742013008456	G-X-G motif; other site
742013008457	SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662
742013008458	cytochrome o ubiquinol oxidase subunit IV; Region: CyoD; TIGR02847
742013008459	Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863
742013008460	Subunit I/III interface [polypeptide binding]; other site
742013008461	Subunit III/IV interface [polypeptide binding]; other site
742013008462	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
742013008463	Ubiquinol oxidase subunit I.  Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662
742013008464	D-pathway; other site
742013008465	Putative ubiquinol binding site [chemical binding]; other site
742013008466	Low-spin heme (heme b) binding site [chemical binding]; other site
742013008467	Putative water exit pathway; other site
742013008468	Binuclear center (heme o3/CuB) [ion binding]; other site
742013008469	K-pathway; other site
742013008470	Putative proton exit pathway; other site
742013008471	cytochrome o ubiquinol oxidase subunit II; Region: CyoA; TIGR01433
742013008472	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
742013008473	COX Aromatic Rich Motif; Region: COX_ARM; pfam06481
742013008474	metabolite-proton symporter; Region: 2A0106; TIGR00883
742013008475	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
742013008476	putative substrate translocation pore; other site
742013008477	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
742013008478	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673
742013008479	motif 1; other site
742013008480	active site
742013008481	motif 2; other site
742013008482	motif 3; other site
742013008483	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
742013008484	DHHA1 domain; Region: DHHA1; pfam02272
742013008485	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
742013008486	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
742013008487	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
742013008488	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
742013008489	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
742013008490	metal binding site [ion binding]; metal-binding site
742013008491	active site
742013008492	I-site; other site
742013008493	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
742013008494	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
742013008495	metal binding site [ion binding]; metal-binding site
742013008496	active site
742013008497	I-site; other site
742013008498	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
742013008499	S-adenosylmethionine binding site [chemical binding]; other site
742013008500	glutamyl-queuosine tRNA(Asp) synthetase; Region: queuosine_YadB; TIGR03838
742013008501	active site
742013008502	HIGH motif; other site
742013008503	nucleotide binding site [chemical binding]; other site
742013008504	active site
742013008505	KMSKS motif; other site
742013008506	Predicted NAD/FAD-dependent oxidoreductase [General function prediction only]; Region: COG3380
742013008507	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
742013008508	Transcriptional regulator [Transcription]; Region: LysR; COG0583
742013008509	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
742013008510	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
742013008511	dimerization interface [polypeptide binding]; other site
742013008512	Pirin-related protein [General function prediction only]; Region: COG1741
742013008513	Pirin; Region: Pirin; pfam02678
742013008514	DoxX; Region: DoxX; pfam07681
742013008515	Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655
742013008516	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
742013008517	rhodanese superfamily protein; Provisional; Region: PRK05320
742013008518	Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518
742013008519	active site residue [active]
742013008520	Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455
742013008521	FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038
742013008522	P-loop; other site
742013008523	FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038
742013008524	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
742013008525	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
742013008526	metal binding site [ion binding]; metal-binding site
742013008527	active site
742013008528	I-site; other site
742013008529	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
742013008530	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
742013008531	Sulfate transporter family; Region: Sulfate_transp; pfam00916
742013008532	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
742013008533	BON domain; Region: BON; pfam04972
742013008534	cystathionine beta-lyase; Provisional; Region: PRK07050
742013008535	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
742013008536	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
742013008537	catalytic residue [active]
742013008538	PhoD-like phosphatase; Region: PhoD; pfam09423
742013008539	Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389
742013008540	putative active site [active]
742013008541	putative metal binding site [ion binding]; other site
742013008542	Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389
742013008543	Predicted integral membrane protein (DUF2189); Region: DUF2189; pfam09955
742013008544	Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822
742013008545	active site
742013008546	catalytic triad [active]
742013008547	oxyanion hole [active]
742013008548	switch loop; other site
742013008549	Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG4181
742013008550	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
742013008551	Walker A/P-loop; other site
742013008552	ATP binding site [chemical binding]; other site
742013008553	Q-loop/lid; other site
742013008554	ABC transporter signature motif; other site
742013008555	Walker B; other site
742013008556	D-loop; other site
742013008557	H-loop/switch region; other site
742013008558	serine/threonine transporter SstT; Provisional; Region: PRK13628
742013008559	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
742013008560	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032
742013008561	23S rRNA (guanosine-2'-O-)-methyltransferase; Provisional; Region: PRK11181
742013008562	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
742013008563	Protein of unknown function (DUF1428); Region: DUF1428; pfam07237
742013008564	Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_3; cd08896
742013008565	putative hydrophobic ligand binding site [chemical binding]; other site
742013008566	N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247
742013008567	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
742013008568	Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588
742013008569	dimer interface [polypeptide binding]; other site
742013008570	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
742013008571	Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588
742013008572	dimer interface [polypeptide binding]; other site
742013008573	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
742013008574	WHG domain; Region: WHG; pfam13305
742013008575	NAD-dependent deacetylase; Provisional; Region: PRK00481
742013008576	SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412
742013008577	NAD+ binding site [chemical binding]; other site
742013008578	substrate binding site [chemical binding]; other site
742013008579	Zn binding site [ion binding]; other site
742013008580	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
742013008581	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
742013008582	active site
742013008583	catalytic tetrad [active]
742013008584	Chromate transporter; Region: Chromate_transp; pfam02417
742013008585	Chromate transporter; Region: Chromate_transp; pfam02417
742013008586	ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178
742013008587	ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549
742013008588	ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223
742013008589	dihydrolipoamide dehydrogenase; Validated; Region: PRK06292
742013008590	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
742013008591	probable extracellular repeat, HAF family; Region: HAF_rpt; TIGR02913
742013008592	pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424
742013008593	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
742013008594	LysR substrate binding domain; Region: LysR_substrate; pfam03466
742013008595	dimerization interface [polypeptide binding]; other site
742013008596	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
742013008597	M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666
742013008598	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
742013008599	metal binding site [ion binding]; metal-binding site
742013008600	putative dimer interface [polypeptide binding]; other site
742013008601	Uncharacterized conserved protein [Function unknown]; Region: COG1739
742013008602	Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205
742013008603	Domain of unknown function (DUF1949); Region: DUF1949; pfam09186
742013008604	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
742013008605	DNA binding residues [nucleotide binding]
742013008606	dimerization interface [polypeptide binding]; other site
742013008607	FAD-dependent oxidoreductase; Provisional; Region: PRK08132
742013008608	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
742013008609	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
742013008610	Cupin; Region: Cupin_6; pfam12852
742013008611	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
742013008612	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
742013008613	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
742013008614	hypothetical protein; Provisional; Region: PRK01254
742013008615	Radical SAM N-terminal; Region: Radical_SAM_N; pfam08497
742013008616	Radical SAM N-terminal; Region: Radical_SAM_N; pfam08497
742013008617	Domain of unknown function (DUF3362); Region: DUF3362; pfam11842
742013008618	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
742013008619	PAS domain; Region: PAS_9; pfam13426
742013008620	putative active site [active]
742013008621	heme pocket [chemical binding]; other site
742013008622	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
742013008623	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
742013008624	metal binding site [ion binding]; metal-binding site
742013008625	active site
742013008626	I-site; other site
742013008627	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
742013008628	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
742013008629	CoA-transferase family III; Region: CoA_transf_3; pfam02515
742013008630	aromatic amino acid aminotransferase; Provisional; Region: PRK09257
742013008631	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
742013008632	pyridoxal 5'-phosphate binding site [chemical binding]; other site
742013008633	homodimer interface [polypeptide binding]; other site
742013008634	catalytic residue [active]
742013008635	excinuclease ABC subunit B; Provisional; Region: PRK05298
742013008636	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
742013008637	ATP binding site [chemical binding]; other site
742013008638	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
742013008639	nucleotide binding region [chemical binding]; other site
742013008640	ATP-binding site [chemical binding]; other site
742013008641	Ultra-violet resistance protein B; Region: UvrB; pfam12344
742013008642	UvrB/uvrC motif; Region: UVR; pfam02151
742013008643	iron-sulfur cluster assembly transcription factor IscR; Region: IscR; TIGR02010
742013008644	Rrf2 family protein; Region: rrf2_super; TIGR00738
742013008645	cysteine desulfurase; Provisional; Region: PRK14012
742013008646	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
742013008647	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
742013008648	catalytic residue [active]
742013008649	NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822
742013008650	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
742013008651	trimerization site [polypeptide binding]; other site
742013008652	active site
742013008653	Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400
742013008654	co-chaperone HscB; Provisional; Region: hscB; PRK03578
742013008655	DnaJ domain; Region: DnaJ; pfam00226
742013008656	HSP70 interaction site [polypeptide binding]; other site
742013008657	HSCB C-terminal oligomerisation domain; Region: HSCB_C; pfam07743
742013008658	chaperone protein HscA; Provisional; Region: hscA; PRK05183
742013008659	Nucleotide-binding domain of HscA and similar proteins; Region: HscA_like_NBD; cd10236
742013008660	nucleotide binding site [chemical binding]; other site
742013008661	putative NEF/HSP70 interaction site [polypeptide binding]; other site
742013008662	SBD interface [polypeptide binding]; other site
742013008663	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
742013008664	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
742013008665	catalytic loop [active]
742013008666	iron binding site [ion binding]; other site
742013008667	DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406
742013008668	DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131
742013008669	active site
742013008670	catalytic site [active]
742013008671	substrate binding site [chemical binding]; other site
742013008672	hydroxyglutarate oxidase; Provisional; Region: PRK11728
742013008673	Predicted dehydrogenase [General function prediction only]; Region: COG0579
742013008674	Bacterial protein of unknown function (DUF883); Region: DUF883; cl01888
742013008675	dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286
742013008676	Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738
742013008677	quinone interaction residues [chemical binding]; other site
742013008678	active site
742013008679	catalytic residues [active]
742013008680	FMN binding site [chemical binding]; other site
742013008681	substrate binding site [chemical binding]; other site
742013008682	RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398
742013008683	tetramer (dimer of dimers) interface [polypeptide binding]; other site
742013008684	active site
742013008685	dimer interface [polypeptide binding]; other site
742013008686	NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976
742013008687	catalytic residues [active]
742013008688	Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339
742013008689	Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456
742013008690	active site
742013008691	Zn binding site [ion binding]; other site
742013008692	bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14189
742013008693	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
742013008694	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
742013008695	homodimer interface [polypeptide binding]; other site
742013008696	NADP binding site [chemical binding]; other site
742013008697	substrate binding site [chemical binding]; other site
742013008698	Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566
742013008699	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
742013008700	active site
742013008701	phosphorylation site [posttranslational modification]
742013008702	intermolecular recognition site; other site
742013008703	dimerization interface [polypeptide binding]; other site
742013008704	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
742013008705	DNA binding residues [nucleotide binding]
742013008706	dimerization interface [polypeptide binding]; other site
742013008707	PAS domain S-box; Region: sensory_box; TIGR00229
742013008708	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
742013008709	putative active site [active]
742013008710	heme pocket [chemical binding]; other site
742013008711	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
742013008712	dimer interface [polypeptide binding]; other site
742013008713	phosphorylation site [posttranslational modification]
742013008714	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
742013008715	ATP binding site [chemical binding]; other site
742013008716	Mg2+ binding site [ion binding]; other site
742013008717	G-X-G motif; other site
742013008718	pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405
742013008719	Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017
742013008720	dimer interface [polypeptide binding]; other site
742013008721	TPP-binding site [chemical binding]; other site
742013008722	dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11855
742013008723	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
742013008724	E3 interaction surface; other site
742013008725	lipoyl attachment site [posttranslational modification]; other site
742013008726	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
742013008727	E3 interaction surface; other site
742013008728	lipoyl attachment site [posttranslational modification]; other site
742013008729	e3 binding domain; Region: E3_binding; pfam02817
742013008730	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
742013008731	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
742013008732	E3 interaction surface; other site
742013008733	lipoyl attachment site [posttranslational modification]; other site
742013008734	dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467
742013008735	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
742013008736	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
742013008737	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
742013008738	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
742013008739	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
742013008740	dimerization interface [polypeptide binding]; other site
742013008741	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
742013008742	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
742013008743	Major Facilitator Superfamily; Region: MFS_1; pfam07690
742013008744	putative substrate translocation pore; other site
742013008745	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
742013008746	EVE domain; Region: EVE; cl00728
742013008747	putative S-transferase; Provisional; Region: PRK11752
742013008748	GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048
742013008749	C-terminal domain interface [polypeptide binding]; other site
742013008750	GSH binding site (G-site) [chemical binding]; other site
742013008751	dimer interface [polypeptide binding]; other site
742013008752	C-terminal, alpha helical domain of Escherichia coli Yghu Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YghU_like; cd10292
742013008753	dimer interface [polypeptide binding]; other site
742013008754	N-terminal domain interface [polypeptide binding]; other site
742013008755	active site
742013008756	Transglycosylase associated protein; Region: Transgly_assoc; pfam04226
742013008757	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
742013008758	NlpC/P60 family; Region: NLPC_P60; pfam00877
742013008759	YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012
742013008760	Isochorismatase family; Region: Isochorismatase; pfam00857
742013008761	catalytic triad [active]
742013008762	dimer interface [polypeptide binding]; other site
742013008763	conserved cis-peptide bond; other site
742013008764	Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637
742013008765	propionyl-CoA synthetase; Provisional; Region: prpE; PRK10524
742013008766	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
742013008767	acyl-activating enzyme (AAE) consensus motif; other site
742013008768	AMP binding site [chemical binding]; other site
742013008769	active site
742013008770	CoA binding site [chemical binding]; other site
742013008771	Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109
742013008772	The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089
742013008773	active site
742013008774	substrate binding site [chemical binding]; other site
742013008775	metal binding site [ion binding]; metal-binding site
742013008776	3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749
742013008777	3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413
742013008778	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
742013008779	oligomeric interface; other site
742013008780	putative active site [active]
742013008781	homodimer interface [polypeptide binding]; other site
742013008782	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604
742013008783	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
742013008784	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
742013008785	dimer interface [polypeptide binding]; other site
742013008786	phosphorylation site [posttranslational modification]
742013008787	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
742013008788	ATP binding site [chemical binding]; other site
742013008789	Mg2+ binding site [ion binding]; other site
742013008790	G-X-G motif; other site
742013008791	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
742013008792	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
742013008793	active site
742013008794	phosphorylation site [posttranslational modification]
742013008795	intermolecular recognition site; other site
742013008796	dimerization interface [polypeptide binding]; other site
742013008797	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
742013008798	DNA binding site [nucleotide binding]
742013008799	type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844
742013008800	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
742013008801	active site residue [active]
742013008802	protein-L-isoaspartate O-methyltransferase; Provisional; Region: PRK13944
742013008803	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
742013008804	S-adenosylmethionine binding site [chemical binding]; other site
742013008805	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
742013008806	Protein export membrane protein; Region: SecD_SecF; cl14618
742013008807	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
742013008808	HlyD family secretion protein; Region: HlyD_3; pfam13437
742013008809	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
742013008810	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
742013008811	Domain of unknown function (DUF1956); Region: DUF1956; pfam09209
742013008812	TrwC relaxase; Region: TrwC; pfam08751
742013008813	conjugative relaxase domain, TrwC/TraI family; Region: relax_trwC; TIGR02686
742013008814	AAA-like domain; Region: AAA_10; pfam12846
742013008815	TraM recognition site of TraD and TraG; Region: TraG-D_C; cl17375
742013008816	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
742013008817	active site
742013008818	Int/Topo IB signature motif; other site
742013008819	DNA binding site [nucleotide binding]
742013008820	methionine sulfoxide reductase A; Provisional; Region: PRK14054
742013008821	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cl17326
742013008822	putative DNA binding helix; other site
742013008823	structural Zn2+ binding site [ion binding]; other site
742013008824	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
742013008825	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
742013008826	N-terminal plug; other site
742013008827	ligand-binding site [chemical binding]; other site
742013008828	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
742013008829	active site
742013008830	Int/Topo IB signature motif; other site
742013008831	DNA binding site [nucleotide binding]
742013008832	Pirin-related protein [General function prediction only]; Region: COG1741
742013008833	Pirin; Region: Pirin; pfam02678
742013008834	Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726
742013008835	Predicted permeases [General function prediction only]; Region: COG0679
742013008836	pyridoxamine-phosphate oxidase; Region: pdxH; TIGR00558
742013008837	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
742013008838	Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590
742013008839	GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182
742013008840	molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317
742013008841	Ligand binding site; other site
742013008842	metal-binding site
742013008843	Transcriptional regulators [Transcription]; Region: MarR; COG1846
742013008844	MarR family; Region: MarR_2; pfam12802
742013008845	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
742013008846	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
742013008847	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
742013008848	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
742013008849	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319
742013008850	CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450
742013008851	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
742013008852	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
742013008853	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_5; cd07823
742013008854	putative hydrophobic ligand binding site [chemical binding]; other site
742013008855	Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305
742013008856	E-class dimer interface [polypeptide binding]; other site
742013008857	P-class dimer interface [polypeptide binding]; other site
742013008858	active site
742013008859	Cu2+ binding site [ion binding]; other site
742013008860	Zn2+ binding site [ion binding]; other site
742013008861	Uncharacterized protein involved in cation transport [Inorganic ion transport and metabolism]; Region: ChaC; COG3703
742013008862	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661
742013008863	putative active site pocket [active]
742013008864	dimerization interface [polypeptide binding]; other site
742013008865	putative catalytic residue [active]
742013008866	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cl02931
742013008867	ligand binding site [chemical binding]; other site
742013008868	Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233
742013008869	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
742013008870	dimer interface [polypeptide binding]; other site
742013008871	active site
742013008872	glutathione binding site [chemical binding]; other site
742013008873	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
742013008874	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
742013008875	active site
742013008876	phosphorylation site [posttranslational modification]
742013008877	intermolecular recognition site; other site
742013008878	dimerization interface [polypeptide binding]; other site
742013008879	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
742013008880	DNA binding residues [nucleotide binding]
742013008881	dimerization interface [polypeptide binding]; other site
742013008882	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
742013008883	dimer interface [polypeptide binding]; other site
742013008884	phosphorylation site [posttranslational modification]
742013008885	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
742013008886	ATP binding site [chemical binding]; other site
742013008887	Mg2+ binding site [ion binding]; other site
742013008888	G-X-G motif; other site
742013008889	Response regulator receiver domain; Region: Response_reg; pfam00072
742013008890	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
742013008891	active site
742013008892	phosphorylation site [posttranslational modification]
742013008893	intermolecular recognition site; other site
742013008894	dimerization interface [polypeptide binding]; other site
742013008895	Hpt domain; Region: Hpt; pfam01627
742013008896	transcriptional regulator RcsB; Provisional; Region: PRK10840
742013008897	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
742013008898	active site
742013008899	phosphorylation site [posttranslational modification]
742013008900	intermolecular recognition site; other site
742013008901	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
742013008902	DNA binding residues [nucleotide binding]
742013008903	dimerization interface [polypeptide binding]; other site
742013008904	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086
742013008905	H-NS histone family; Region: Histone_HNS; pfam00816
742013008906	Domain in histone-like proteins of HNS family; Region: HNS; smart00528
742013008907	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
742013008908	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2; pfam00111
742013008909	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085
742013008910	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
742013008911	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
742013008912	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
742013008913	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
742013008914	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
742013008915	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
742013008916	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
742013008917	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
742013008918	Cytochrome c; Region: Cytochrom_C; pfam00034
742013008919	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
742013008920	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
742013008921	active site
742013008922	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
742013008923	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
742013008924	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
742013008925	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060
742013008926	Metal-binding active site; metal-binding site
742013008927	AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582
742013008928	Epoxide hydrolase N terminus; Region: EHN; pfam06441
742013008929	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
742013008930	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
742013008931	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
742013008932	Domain of unknown function (DUF4287); Region: DUF4287; pfam14117
742013008933	Bestrophin, RFP-TM, chloride channel; Region: Bestrophin; pfam01062
742013008934	Transcriptional regulator [Transcription]; Region: LysR; COG0583
742013008935	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
742013008936	Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer,  utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514
742013008937	FMN binding site [chemical binding]; other site
742013008938	dimer interface [polypeptide binding]; other site
742013008939	Transcriptional regulator [Transcription]; Region: LysR; COG0583
742013008940	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
742013008941	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
742013008942	dimerization interface [polypeptide binding]; other site
742013008943	EamA-like transporter family; Region: EamA; pfam00892
742013008944	EamA-like transporter family; Region: EamA; pfam00892
742013008945	aspartate 4-decarboxylase; Region: asp_4_decarbox; TIGR03801
742013008946	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
742013008947	pyridoxal 5'-phosphate binding site [chemical binding]; other site
742013008948	homodimer interface [polypeptide binding]; other site
742013008949	catalytic residue [active]
742013008950	aspartate-alanine antiporter; Region: Asp_Ala_antiprt; TIGR03802
742013008951	Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826
742013008952	TrkA-C domain; Region: TrkA_C; pfam02080
742013008953	Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826
742013008954	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474
742013008955	active site
742013008956	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
742013008957	Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615
742013008958	active site
742013008959	catalytic site [active]
742013008960	dihydroxy-acid dehydratase; Provisional; Region: PRK13016
742013008961	2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase [Carbohydrate transport and metabolism]; Region: HpcH; COG3836
742013008962	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
742013008963	Transcriptional regulators [Transcription]; Region: PurR; COG1609
742013008964	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
742013008965	DNA binding site [nucleotide binding]
742013008966	domain linker motif; other site
742013008967	Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575
742013008968	putative dimerization interface [polypeptide binding]; other site
742013008969	putative ligand binding site [chemical binding]; other site
742013008970	Uncharacterized conserved protein [Function unknown]; Region: COG3339
742013008971	AAA domain; Region: AAA_14; pfam13173
742013008972	zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240
742013008973	Restriction endonuclease; Region: Mrr_cat; pfam04471
742013008974	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
742013008975	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
742013008976	OsmC-like protein; Region: OsmC; cl00767
742013008977	Cupredoxin-like domain; Region: Cupredoxin_1; cl17234
742013008978	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
742013008979	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
742013008980	Walker A/P-loop; other site
742013008981	ATP binding site [chemical binding]; other site
742013008982	Q-loop/lid; other site
742013008983	ABC transporter signature motif; other site
742013008984	Walker B; other site
742013008985	D-loop; other site
742013008986	H-loop/switch region; other site
742013008987	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
742013008988	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
742013008989	ABC-ATPase subunit  interface; other site
742013008990	dimer interface [polypeptide binding]; other site
742013008991	putative PBP binding regions; other site
742013008992	Periplasmic binding protein TroA_f.  These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea.  They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_f; cd01139
742013008993	putative ligand binding residues [chemical binding]; other site
742013008994	Outer membrane receptor for monomeric catechols [Inorganic ion transport and metabolism]; Region: Fiu; COG4774
742013008995	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
742013008996	N-terminal plug; other site
742013008997	ligand-binding site [chemical binding]; other site
742013008998	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
742013008999	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
742013009000	active site
742013009001	phosphorylation site [posttranslational modification]
742013009002	intermolecular recognition site; other site
742013009003	dimerization interface [polypeptide binding]; other site
742013009004	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
742013009005	DNA binding site [nucleotide binding]
742013009006	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
742013009007	dimer interface [polypeptide binding]; other site
742013009008	phosphorylation site [posttranslational modification]
742013009009	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
742013009010	ATP binding site [chemical binding]; other site
742013009011	Mg2+ binding site [ion binding]; other site
742013009012	G-X-G motif; other site
742013009013	SprT homologues; Region: SprT; cl01182
742013009014	SprT-like family; Region: SprT-like; pfam10263
742013009015	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
742013009016	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
742013009017	DNA binding residues [nucleotide binding]
742013009018	dimerization interface [polypeptide binding]; other site
742013009019	DNA-binding HTH domain-containing proteins [Transcription]; Region: CsgD; COG2771
742013009020	DNA binding residues [nucleotide binding]
742013009021	dimerization interface [polypeptide binding]; other site
742013009022	Flavin reductase like domain; Region: Flavin_Reduct; smart00903
742013009023	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
742013009024	CC3(TIP30)-like, atypical (a) SDRs; Region: CC3_like_SDR_a; cd05250
742013009025	NAD binding site [chemical binding]; other site
742013009026	active site
742013009027	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
742013009028	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933
742013009029	FMN binding site [chemical binding]; other site
742013009030	active site
742013009031	substrate binding site [chemical binding]; other site
742013009032	catalytic residue [active]
742013009033	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
742013009034	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
742013009035	Transcriptional regulator [Transcription]; Region: LysR; COG0583
742013009036	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
742013009037	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
742013009038	putative effector binding pocket; other site
742013009039	dimerization interface [polypeptide binding]; other site
742013009040	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
742013009041	AMP-binding domain protein; Validated; Region: PRK07529
742013009042	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
742013009043	Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_4; cd05944
742013009044	acyl-activating enzyme (AAE) consensus motif; other site
742013009045	acyl-activating enzyme (AAE) consensus motif; other site
742013009046	putative AMP binding site [chemical binding]; other site
742013009047	putative active site [active]
742013009048	putative CoA binding site [chemical binding]; other site
742013009049	Domain of unknown function (DUF4198); Region: DUF4198; pfam10670
742013009050	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
742013009051	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
742013009052	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
742013009053	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
742013009054	dimer interface [polypeptide binding]; other site
742013009055	conserved gate region; other site
742013009056	putative PBP binding loops; other site
742013009057	ABC-ATPase subunit interface; other site
742013009058	Uncharacterized conserved protein [Function unknown]; Region: COG1262
742013009059	Domain of unknown function (DUF4150); Region: DUF4150; pfam13665
742013009060	Uncharacterized protein conserved in bacteria (DUF2169); Region: DUF2169; pfam09937
742013009061	type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361
742013009062	Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954
742013009063	Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717
742013009064	PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal)...; Region: PDZ_signaling; cd00992
742013009065	C-terminal processing peptidase family S41; Region: Peptidase_S41; cd06567
742013009066	Active site serine [active]
742013009067	type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345
742013009068	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
742013009069	Walker A motif; other site
742013009070	ATP binding site [chemical binding]; other site
742013009071	Walker B motif; other site
742013009072	arginine finger; other site
742013009073	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
742013009074	Walker A motif; other site
742013009075	ATP binding site [chemical binding]; other site
742013009076	Walker B motif; other site
742013009077	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
742013009078	Protein of unknown function (DUF1305); Region: DUF1305; pfam06996
742013009079	Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and    vesicular transport]; Region: COG3519
742013009080	Bacterial protein of unknown function (DUF879); Region: DUF879; pfam05947
742013009081	Gene 25-like lysozyme; Region: GPW_gp25; cl01403
742013009082	Protein of avirulence locus involved in temperature-dependent protein secretion [General function prediction only]; Region: ImpE; COG4455
742013009083	ImpE protein; Region: ImpE; pfam07024
742013009084	Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and    vesicular transport]; Region: COG3517
742013009085	Protein of unknown function (DUF877); Region: DUF877; pfam05943
742013009086	Protein of unknown function (DUF770); Region: DUF770; pfam05591
742013009087	type VI secretion-associated protein, ImpA family; Region: VI_chp_8; TIGR03363
742013009088	ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812
742013009089	Uncharacterized protein conserved in bacteria (DUF2094); Region: DUF2094; pfam09867
742013009090	type VI secretion protein IcmF; Region: VI_IcmF; TIGR03348
742013009091	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882
742013009092	G1 box; other site
742013009093	GTP/Mg2+ binding site [chemical binding]; other site
742013009094	G2 box; other site
742013009095	G3 box; other site
742013009096	Switch II region; other site
742013009097	G4 box; other site
742013009098	Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761
742013009099	Protein of unknown function (DUF1215); Region: DUF1215; pfam06744
742013009100	hypothetical protein; Provisional; Region: PRK07033
742013009101	Uncharacterized protein conserved in bacteria (DUF2077); Region: DUF2077; pfam09850
742013009102	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
742013009103	ligand binding site [chemical binding]; other site
742013009104	type VI secretion protein, VC_A0114 family; Region: VI_chp_4; TIGR03353
742013009105	Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936
742013009106	Type VI secretion lipoprotein; Region: T6SS-SciN; pfam12790
742013009107	Serine/threonine protein phosphatase [Signal transduction mechanisms]; Region: PTC1; COG0631
742013009108	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
742013009109	phosphopeptide binding site; other site
742013009110	PEGA domain; Region: PEGA; pfam08308
742013009111	Protein kinase domain; Region: Pkinase; pfam00069
742013009112	Catalytic domain of Protein Kinases; Region: PKc; cd00180
742013009113	active site
742013009114	ATP binding site [chemical binding]; other site
742013009115	substrate binding site [chemical binding]; other site
742013009116	activation loop (A-loop); other site
742013009117	sec-independent translocase; Provisional; Region: tatB; PRK00404
742013009118	PEGA domain; Region: PEGA; pfam08308
742013009119	Protein of unknown function (DUF796); Region: DUF796; pfam05638
742013009120	Transcriptional regulators [Transcription]; Region: FadR; COG2186
742013009121	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
742013009122	DNA-binding site [nucleotide binding]; DNA binding site
742013009123	FCD domain; Region: FCD; pfam07729
742013009124	Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195
742013009125	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
742013009126	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
742013009127	dimerization interface [polypeptide binding]; other site
742013009128	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
742013009129	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
742013009130	dimer interface [polypeptide binding]; other site
742013009131	putative CheW interface [polypeptide binding]; other site
742013009132	CHASE3 domain; Region: CHASE3; pfam05227
742013009133	GAF domain; Region: GAF_2; pfam13185
742013009134	GAF domain; Region: GAF; pfam01590
742013009135	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
742013009136	dimer interface [polypeptide binding]; other site
742013009137	phosphorylation site [posttranslational modification]
742013009138	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
742013009139	ATP binding site [chemical binding]; other site
742013009140	Mg2+ binding site [ion binding]; other site
742013009141	G-X-G motif; other site
742013009142	Response regulator receiver domain; Region: Response_reg; pfam00072
742013009143	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
742013009144	active site
742013009145	phosphorylation site [posttranslational modification]
742013009146	intermolecular recognition site; other site
742013009147	dimerization interface [polypeptide binding]; other site
742013009148	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
742013009149	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
742013009150	active site
742013009151	phosphorylation site [posttranslational modification]
742013009152	intermolecular recognition site; other site
742013009153	dimerization interface [polypeptide binding]; other site
742013009154	Response regulator receiver domain; Region: Response_reg; pfam00072
742013009155	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
742013009156	active site
742013009157	phosphorylation site [posttranslational modification]
742013009158	intermolecular recognition site; other site
742013009159	dimerization interface [polypeptide binding]; other site
742013009160	Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352
742013009161	CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705
742013009162	CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739
742013009163	Chemotaxis response regulator containing a CheY-like receiver domain and a methylesterase domain [Cell motility and secretion / Signal transduction mechanisms]; Region: CheB; COG2201
742013009164	CheB methylesterase; Region: CheB_methylest; pfam01339
742013009165	Response regulator receiver domain; Region: Response_reg; pfam00072
742013009166	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
742013009167	active site
742013009168	phosphorylation site [posttranslational modification]
742013009169	intermolecular recognition site; other site
742013009170	dimerization interface [polypeptide binding]; other site
742013009171	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
742013009172	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
742013009173	dimer interface [polypeptide binding]; other site
742013009174	phosphorylation site [posttranslational modification]
742013009175	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
742013009176	ATP binding site [chemical binding]; other site
742013009177	Mg2+ binding site [ion binding]; other site
742013009178	G-X-G motif; other site
742013009179	Response regulator receiver domain; Region: Response_reg; pfam00072
742013009180	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
742013009181	active site
742013009182	phosphorylation site [posttranslational modification]
742013009183	intermolecular recognition site; other site
742013009184	dimerization interface [polypeptide binding]; other site
742013009185	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
742013009186	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
742013009187	active site
742013009188	metal binding site [ion binding]; metal-binding site
742013009189	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
742013009190	active site
742013009191	metal binding site [ion binding]; metal-binding site
742013009192	Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597
742013009193	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA; cl00391
742013009194	Cache domain; Region: Cache_1; pfam02743
742013009195	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
742013009196	dimerization interface [polypeptide binding]; other site
742013009197	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
742013009198	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
742013009199	metal binding site [ion binding]; metal-binding site
742013009200	active site
742013009201	I-site; other site
742013009202	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
742013009203	Uncharacterized protein conserved in bacteria (DUF2170); Region: DUF2170; pfam09938
742013009204	PspA/IM30 family; Region: PspA_IM30; pfam04012
742013009205	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268
742013009206	Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  These two proteins are lipid raft-associated.  Individual proteins of...; Region: Band_7_flotillin; cd03399
742013009207	ATPase involved in DNA repair; Region: DUF3686; pfam12458
742013009208	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
742013009209	aldehyde oxidoreductase 2Fe-2S subunit; Provisional; Region: PRK11433
742013009210	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
742013009211	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319
742013009212	CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092
742013009213	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
742013009214	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
742013009215	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
742013009216	benzoate transport; Region: 2A0115; TIGR00895
742013009217	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
742013009218	putative substrate translocation pore; other site
742013009219	The A subunit of Protocatechuate 4,5-dioxygenase (LigAB) is the smaller, non-catalytic subunit; Region: PCA_45_Doxase_A; cd07924
742013009220	tetramer interface [polypeptide binding]; other site
742013009221	dimer interface [polypeptide binding]; other site
742013009222	active site
742013009223	Subunit B of the Class III extradiol dioxygenase, Protocatechuate 4,5-dioxygenase, which catalyzes the oxidization and subsequent ring-opening of protocatechuate; Region: PCA_45_Dioxygenase_B; cd07364
742013009224	Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900
742013009225	active site
742013009226	Fe(II) binding site [ion binding]; other site
742013009227	dimer interface [polypeptide binding]; other site
742013009228	tetramer interface [polypeptide binding]; other site
742013009229	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
742013009230	Transcriptional regulator [Transcription]; Region: LysR; COG0583
742013009231	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
742013009232	Transcriptional regulator [Transcription]; Region: LysR; COG0583
742013009233	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
742013009234	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
742013009235	dimerization interface [polypeptide binding]; other site
742013009236	SnoaL-like domain; Region: SnoaL_4; pfam13577
742013009237	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
742013009238	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
742013009239	trimer interface [polypeptide binding]; other site
742013009240	eyelet of channel; other site
742013009241	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5343
742013009242	Anti-sigma-K factor rskA; Region: RskA; pfam10099
742013009243	RNA polymerase sigma factor; Provisional; Region: PRK12537
742013009244	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
742013009245	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
742013009246	DNA binding residues [nucleotide binding]
742013009247	Protein of unknown function (DUF3455); Region: DUF3455; pfam11937
742013009248	Dyp-type peroxidase family; Region: Dyp_perox; cl01067
742013009249	Bacillus subtilis YydB and related proteins, metallophosphatase domain; Region: MPP_YydB; cd07400
742013009250	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
742013009251	putative active site [active]
742013009252	putative metal binding site [ion binding]; other site
742013009253	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
742013009254	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
742013009255	Walker A motif; other site
742013009256	ATP binding site [chemical binding]; other site
742013009257	Walker B motif; other site
742013009258	Uncharacterized protein conserved in bacteria (DUF2086); Region: DUF2086; pfam09859
742013009259	alpha-ketoglutarate-dependent dioxygenase AlkB; Provisional; Region: PRK15401
742013009260	Uncharacterized protein conserved in bacteria (DUF2086); Region: DUF2086; cl17606
742013009261	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
742013009262	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
742013009263	N-terminal plug; other site
742013009264	ligand-binding site [chemical binding]; other site
742013009265	proposed F420-0 ABC transporter, periplasmic F420-0 binding protein; Region: F420-O_ABCperi; TIGR03868
742013009266	Metal binding protein TroA_a.  These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and...; Region: TroA_a; cd01148
742013009267	putative ligand binding residues [chemical binding]; other site
742013009268	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
742013009269	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
742013009270	dimer interface [polypeptide binding]; other site
742013009271	putative PBP binding regions; other site
742013009272	ABC-ATPase subunit  interface; other site
742013009273	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
742013009274	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
742013009275	Walker A/P-loop; other site
742013009276	ATP binding site [chemical binding]; other site
742013009277	Q-loop/lid; other site
742013009278	ABC transporter signature motif; other site
742013009279	Walker B; other site
742013009280	D-loop; other site
742013009281	H-loop/switch region; other site
742013009282	Class II Chelatase: a family of ATP-independent monomeric or homodimeric enzymes that catalyze the insertion of metal into protoporphyrin rings. This family includes protoporphyrin IX ferrochelatase (HemH), sirohydrochlorin ferrochelatase (SirB) and the...; Region: Chelatase_Class_II; cl02784
742013009283	active site
742013009284	Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980
742013009285	dimer interface [polypeptide binding]; other site
742013009286	[2Fe-2S] cluster binding site [ion binding]; other site
742013009287	Transcriptional regulator [Transcription]; Region: LysR; COG0583
742013009288	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
742013009289	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
742013009290	putative effector binding pocket; other site
742013009291	dimerization interface [polypeptide binding]; other site
742013009292	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
742013009293	Beta-lactamase; Region: Beta-lactamase; pfam00144
742013009294	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
742013009295	dimerization interface [polypeptide binding]; other site
742013009296	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
742013009297	dimer interface [polypeptide binding]; other site
742013009298	putative CheW interface [polypeptide binding]; other site
742013009299	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
742013009300	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
742013009301	phosphonate utilization associated transcriptional regulator; Region: phnR_burk; TIGR03338
742013009302	DNA-binding site [nucleotide binding]; DNA binding site
742013009303	FCD domain; Region: FCD; pfam07729
742013009304	Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405
742013009305	Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019
742013009306	Transcriptional regulators [Transcription]; Region: GntR; COG1802
742013009307	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
742013009308	DNA-binding site [nucleotide binding]; DNA binding site
742013009309	FCD domain; Region: FCD; pfam07729
742013009310	Plasmid replication region DNA-binding N-term; Region: KfrA_N; pfam11740
742013009311	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
742013009312	active site
742013009313	DNA binding site [nucleotide binding]
742013009314	Int/Topo IB signature motif; other site
742013009315	biotin synthase; Region: bioB; TIGR00433
742013009316	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
742013009317	FeS/SAM binding site; other site
742013009318	Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876
742013009319	Part of AAA domain; Region: AAA_19; pfam13245
742013009320	Family description; Region: UvrD_C_2; pfam13538
742013009321	Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249
742013009322	dimer interface [polypeptide binding]; other site
742013009323	substrate binding site [chemical binding]; other site
742013009324	metal binding site [ion binding]; metal-binding site
742013009325	Uncharacterized conserved protein [Function unknown]; Region: COG1434
742013009326	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
742013009327	putative active site [active]
742013009328	Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652
742013009329	Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161
742013009330	putative sugar binding sites [chemical binding]; other site
742013009331	Q-X-W motif; other site
742013009332	enoyl-CoA hydratase; Provisional; Region: PRK06127
742013009333	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
742013009334	substrate binding site [chemical binding]; other site
742013009335	oxyanion hole (OAH) forming residues; other site
742013009336	trimer interface [polypeptide binding]; other site
742013009337	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
742013009338	CoA-transferase family III; Region: CoA_transf_3; pfam02515
742013009339	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
742013009340	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
742013009341	Transcriptional regulator [Transcription]; Region: LysR; COG0583
742013009342	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
742013009343	dimerization interface [polypeptide binding]; other site
742013009344	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
742013009345	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
742013009346	metal binding site [ion binding]; metal-binding site
742013009347	active site
742013009348	I-site; other site
742013009349	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
742013009350	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
742013009351	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
742013009352	dimer interface [polypeptide binding]; other site
742013009353	putative CheW interface [polypeptide binding]; other site
742013009354	keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718
742013009355	KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452
742013009356	active site
742013009357	intersubunit interface [polypeptide binding]; other site
742013009358	catalytic residue [active]
742013009359	phosphogluconate dehydratase; Validated; Region: PRK09054
742013009360	6-phosphogluconate dehydratase; Region: edd; TIGR01196
742013009361	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
742013009362	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480
742013009363	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274
742013009364	DctM-like transporters; Region: DctM; pfam06808
742013009365	TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090
742013009366	Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021
742013009367	AAA domain; Region: AAA_33; pfam13671
742013009368	ATP-binding site [chemical binding]; other site
742013009369	Gluconate-6-phosphate binding site [chemical binding]; other site
742013009370	Transcriptional regulators [Transcription]; Region: PurR; COG1609
742013009371	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
742013009372	DNA binding site [nucleotide binding]
742013009373	domain linker motif; other site
742013009374	Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575
742013009375	putative ligand binding site [chemical binding]; other site
742013009376	putative dimerization interface [polypeptide binding]; other site
742013009377	Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835
742013009378	Response regulator receiver domain; Region: Response_reg; pfam00072
742013009379	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
742013009380	active site
742013009381	phosphorylation site [posttranslational modification]
742013009382	intermolecular recognition site; other site
742013009383	dimerization interface [polypeptide binding]; other site
742013009384	Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770
742013009385	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
742013009386	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
742013009387	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
742013009388	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
742013009389	carboxyltransferase (CT) interaction site; other site
742013009390	biotinylation site [posttranslational modification]; other site
742013009391	Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799
742013009392	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
742013009393	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
742013009394	membrane ATPase/protein kinase; Provisional; Region: PRK09435
742013009395	The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114
742013009396	Walker A; other site
742013009397	methylmalonyl-CoA mutase; Reviewed; Region: PRK09426
742013009398	Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679
742013009399	active site
742013009400	substrate binding site [chemical binding]; other site
742013009401	coenzyme B12 binding site [chemical binding]; other site
742013009402	methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071
742013009403	B12 binding site [chemical binding]; other site
742013009404	cobalt ligand [ion binding]; other site
742013009405	Transcriptional regulators [Transcription]; Region: GntR; COG1802
742013009406	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
742013009407	DNA-binding site [nucleotide binding]; DNA binding site
742013009408	FCD domain; Region: FCD; pfam07729
742013009409	Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022
742013009410	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
742013009411	Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907
742013009412	acyl-activating enzyme (AAE) consensus motif; other site
742013009413	acyl-activating enzyme (AAE) consensus motif; other site
742013009414	putative AMP binding site [chemical binding]; other site
742013009415	putative active site [active]
742013009416	putative CoA binding site [chemical binding]; other site
742013009417	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
742013009418	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
742013009419	dimerization interface [polypeptide binding]; other site
742013009420	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
742013009421	dimer interface [polypeptide binding]; other site
742013009422	putative CheW interface [polypeptide binding]; other site
742013009423	Predicted membrane protein [Function unknown]; Region: COG4541
742013009424	Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296
742013009425	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
742013009426	MarR family; Region: MarR; pfam01047
742013009427	MarR family; Region: MarR_2; cl17246
742013009428	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
742013009429	multidrug efflux system protein EmrA; Provisional; Region: PRK15136
742013009430	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
742013009431	HlyD family secretion protein; Region: HlyD_3; pfam13437
742013009432	Major Facilitator Superfamily; Region: MFS_1; pfam07690
742013009433	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
742013009434	putative substrate translocation pore; other site
742013009435	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
742013009436	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
742013009437	Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706
742013009438	D-alanine/D-serine/glycine permease; Provisional; Region: PRK11049
742013009439	Outer membrane receptor for ferrienterochelin and colicins [Inorganic ion transport and metabolism]; Region: FepA; COG4771
742013009440	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
742013009441	N-terminal plug; other site
742013009442	ligand-binding site [chemical binding]; other site
742013009443	Predicted transcriptional regulators [Transcription]; Region: COG1733
742013009444	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
742013009445	Cupin domain; Region: Cupin_2; pfam07883
742013009446	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
742013009447	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
742013009448	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
742013009449	non-specific DNA binding site [nucleotide binding]; other site
742013009450	salt bridge; other site
742013009451	sequence-specific DNA binding site [nucleotide binding]; other site
742013009452	Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206
742013009453	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
742013009454	N-terminal plug; other site
742013009455	ligand-binding site [chemical binding]; other site
742013009456	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
742013009457	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
742013009458	intersubunit interface [polypeptide binding]; other site
742013009459	hypothetical protein; Provisional; Region: PRK02877
742013009460	GIY-YIG domain of uncharacterized hypothetical protein found in bacteria; Region: GIY-YIG_unchar_1; cd10446
742013009461	GIY-YIG motif/motif A; other site
742013009462	putative active site [active]
742013009463	putative metal binding site [ion binding]; other site
742013009464	H-NS histone family; Region: Histone_HNS; pfam00816
742013009465	Domain in histone-like proteins of HNS family; Region: HNS; smart00528
742013009466	Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329
742013009467	GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518
742013009468	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741
742013009469	catalytic triad [active]
742013009470	Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cd00322
742013009471	FAD binding pocket [chemical binding]; other site
742013009472	conserved FAD binding motif [chemical binding]; other site
742013009473	phosphate binding motif [ion binding]; other site
742013009474	beta-alpha-beta structure motif; other site
742013009475	NAD binding pocket [chemical binding]; other site
742013009476	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
742013009477	catalytic loop [active]
742013009478	iron binding site [ion binding]; other site
742013009479	P-aminobenzoate N-oxygenase AurF; Region: AurF; pfam11583
742013009480	serine hydroxymethyltransferase; Reviewed; Region: PRK13034
742013009481	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
742013009482	dimer interface [polypeptide binding]; other site
742013009483	active site
742013009484	glycine-pyridoxal phosphate binding site [chemical binding]; other site
742013009485	folate binding site [chemical binding]; other site
742013009486	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
742013009487	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
742013009488	DNA-binding site [nucleotide binding]; DNA binding site
742013009489	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
742013009490	pyridoxal 5'-phosphate binding site [chemical binding]; other site
742013009491	homodimer interface [polypeptide binding]; other site
742013009492	catalytic residue [active]
742013009493	benzoate transporter; Region: benE; TIGR00843
742013009494	Benzoate membrane transport protein; Region: BenE; pfam03594
742013009495	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635
742013009496	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
742013009497	catalytic residue [active]
742013009498	acetylornithine aminotransferase; Provisional; Region: PRK02627
742013009499	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
742013009500	inhibitor-cofactor binding pocket; inhibition site
742013009501	pyridoxal 5'-phosphate binding site [chemical binding]; other site
742013009502	catalytic residue [active]
742013009503	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
742013009504	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
742013009505	dimer interface [polypeptide binding]; other site
742013009506	active site
742013009507	glycine-pyridoxal phosphate binding site [chemical binding]; other site
742013009508	folate binding site [chemical binding]; other site
742013009509	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
742013009510	Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205
742013009511	active site
742013009512	nucleophile elbow; other site
742013009513	Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093
742013009514	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
742013009515	non-specific DNA binding site [nucleotide binding]; other site
742013009516	salt bridge; other site
742013009517	sequence-specific DNA binding site [nucleotide binding]; other site
742013009518	Plasmid maintenance system killer protein; Region: Plasmid_killer; cl01422
742013009519	Transcriptional regulator [Transcription]; Region: LysR; COG0583
742013009520	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
742013009521	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
742013009522	dimerization interface [polypeptide binding]; other site
742013009523	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
742013009524	MarR family; Region: MarR_2; pfam12802
742013009525	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
742013009526	Transposase, Mutator family; Region: Transposase_mut; pfam00872
742013009527	MULE transposase domain; Region: MULE; pfam10551
742013009528	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; cl17722
742013009529	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
742013009530	H-NS histone family; Region: Histone_HNS; pfam00816
742013009531	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
742013009532	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
742013009533	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
742013009534	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
742013009535	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686
742013009536	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
742013009537	Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943
742013009538	Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009
742013009539	Transglycosylase; Region: Transgly; pfam00912
742013009540	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
742013009541	Esterase-like activity of phytase; Region: Phytase-like; pfam13449
742013009542	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
742013009543	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
742013009544	trimer interface [polypeptide binding]; other site
742013009545	eyelet of channel; other site
742013009546	PAS domain S-box; Region: sensory_box; TIGR00229
742013009547	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
742013009548	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
742013009549	heme pocket [chemical binding]; other site
742013009550	putative active site [active]
742013009551	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
742013009552	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
742013009553	putative active site [active]
742013009554	heme pocket [chemical binding]; other site
742013009555	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
742013009556	dimer interface [polypeptide binding]; other site
742013009557	phosphorylation site [posttranslational modification]
742013009558	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
742013009559	ATP binding site [chemical binding]; other site
742013009560	Mg2+ binding site [ion binding]; other site
742013009561	G-X-G motif; other site
742013009562	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
742013009563	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
742013009564	active site
742013009565	phosphorylation site [posttranslational modification]
742013009566	intermolecular recognition site; other site
742013009567	dimerization interface [polypeptide binding]; other site
742013009568	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
742013009569	DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986
742013009570	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to regulators involved in the catabolism of aromatic compounds, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like_2; cd08448
742013009571	putative dimerization interface [polypeptide binding]; other site
742013009572	putative substrate binding pocket [chemical binding]; other site
742013009573	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
742013009574	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
742013009575	active site
742013009576	Cupin domain; Region: Cupin_2; pfam07883
742013009577	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
742013009578	CoA-transferase family III; Region: CoA_transf_3; pfam02515
742013009579	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181
742013009580	Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_2; cd08895
742013009581	putative hydrophobic ligand binding site [chemical binding]; other site
742013009582	Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917
742013009583	RNA polymerase sigma factor FecI; Provisional; Region: PRK09651
742013009584	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
742013009585	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
742013009586	DNA binding residues [nucleotide binding]
742013009587	fec operon regulator FecR; Reviewed; Region: PRK09774
742013009588	FecR protein; Region: FecR; pfam04773
742013009589	Secretin and TonB N terminus short domain; Region: STN; smart00965
742013009590	Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion transport and metabolism]; Region: FhuE; COG4773
742013009591	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
742013009592	N-terminal plug; other site
742013009593	ligand-binding site [chemical binding]; other site
742013009594	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
742013009595	DNA-binding site [nucleotide binding]; DNA binding site
742013009596	transcriptional regulatory protein PtsJ; Provisional; Region: PRK15481
742013009597	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
742013009598	pyridoxal 5'-phosphate binding site [chemical binding]; other site
742013009599	homodimer interface [polypeptide binding]; other site
742013009600	catalytic residue [active]
742013009601	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
742013009602	tRNA 2-selenouridine synthase; Provisional; Region: PRK11784
742013009603	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
742013009604	active site residue [active]
742013009605	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
742013009606	Beta-lactamase; Region: Beta-lactamase; pfam00144
742013009607	Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483
742013009608	catalytic motif [active]
742013009609	Catalytic residue [active]
742013009610	DsbA family, FrnE-like subfamily; composed of uncharacterized proteins containing a CXXC motif with similarity to DsbA and FrnE. FrnE is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the...; Region: DsbA_FrnE_like; cd03025
742013009611	Predicted protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: COG3531
742013009612	catalytic residues [active]
742013009613	isocitrate dehydrogenase; Validated; Region: PRK07362
742013009614	isocitrate dehydrogenase; Reviewed; Region: PRK07006
742013009615	Uncharacterized ACR, COG1430; Region: DUF192; pfam02643
742013009616	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
742013009617	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
742013009618	N-terminal plug; other site
742013009619	ligand-binding site [chemical binding]; other site
742013009620	PepSY-associated TM helix; Region: PepSY_TM_3; pfam13706
742013009621	PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703
742013009622	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
742013009623	MarR family; Region: MarR; pfam01047
742013009624	DNA alkylation repair enzyme [DNA replication, recombination, and repair]; Region: COG4335
742013009625	ferric uptake regulator; Provisional; Region: fur; PRK09462
742013009626	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
742013009627	metal binding site 2 [ion binding]; metal-binding site
742013009628	putative DNA binding helix; other site
742013009629	metal binding site 1 [ion binding]; metal-binding site
742013009630	dimer interface [polypeptide binding]; other site
742013009631	structural Zn2+ binding site [ion binding]; other site
742013009632	Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663
742013009633	Gamma carbonic anhydrases (CA): Carbonic anhydrases are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism, involving the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide, followed...; Region: LbH_gamma_CA; cd00710
742013009634	trimer interface [polypeptide binding]; other site
742013009635	active site
742013009636	50S ribosomal protein L36; Validated; Region: rpmJ; PRK00831
742013009637	putative GTP cyclohydrolase; Provisional; Region: PRK13674
742013009638	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
742013009639	CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492
742013009640	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833
742013009641	Fe2+/Zn2+ uptake regulation proteins [Inorganic ion transport and metabolism]; Region: Fur; COG0735
742013009642	metal binding site 2 [ion binding]; metal-binding site
742013009643	putative DNA binding helix; other site
742013009644	metal binding site 1 [ion binding]; metal-binding site
742013009645	dimer interface [polypeptide binding]; other site
742013009646	structural Zn2+ binding site [ion binding]; other site
742013009647	RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724
742013009648	RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399
742013009649	Monomeric isocitrate dehydrogenase [Energy production and conversion]; Region: Icd; COG2838
742013009650	Monomeric isocitrate dehydrogenase; Region: IDH; cl15383
742013009651	Helix-turn-helix domain; Region: HTH_18; pfam12833
742013009652	Cytochrome P450; Region: p450; cl12078
742013009653	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
742013009654	Citrate transporter; Region: CitMHS; pfam03600
742013009655	fructuronate transporter; Provisional; Region: PRK10034; cl15264
742013009656	H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610
742013009657	acylamide amidohydrolase; Provisional; Region: amiE; PRK13286
742013009658	aliphatic amidases (class 2 nitrilases); Region: aliphatic_amidase; cd07565
742013009659	multimer interface [polypeptide binding]; other site
742013009660	active site
742013009661	catalytic triad [active]
742013009662	dimer interface [polypeptide binding]; other site
742013009663	MoxR-like ATPases [General function prediction only]; Region: COG0714
742013009664	AAA domain (dynein-related subfamily); Region: AAA_5; pfam07728
742013009665	Walker A motif; other site
742013009666	ATP binding site [chemical binding]; other site
742013009667	Walker B motif; other site
742013009668	CbbQ/NirQ/NorQ C-terminal; Region: CbbQ_C; pfam08406
742013009669	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
742013009670	metal ion-dependent adhesion site (MIDAS); other site
742013009671	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
742013009672	Periplasmic binding domain of amidase (AmiC) that belongs to the type I periplasmic binding fold protein family; Region: PBP1_AmiC; cd06357
742013009673	ligand binding site [chemical binding]; other site
742013009674	regulator interaction site; other site
742013009675	Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707
742013009676	ANTAR domain; Region: ANTAR; pfam03861
742013009677	Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437
742013009678	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
742013009679	active site
742013009680	phosphorylation site [posttranslational modification]
742013009681	intermolecular recognition site; other site
742013009682	dimerization interface [polypeptide binding]; other site
742013009683	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
742013009684	Zn2+ binding site [ion binding]; other site
742013009685	Mg2+ binding site [ion binding]; other site
742013009686	PLD-like domain; Region: PLDc_2; pfam13091
742013009687	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
742013009688	putative active site [active]
742013009689	catalytic site [active]
742013009690	Protein of unknown function (DUF4043); Region: DUF4043; pfam13252
742013009691	IPTL-CTERM protein sorting domain; Region: IPTL_CTERM; TIGR04174
742013009692	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
742013009693	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
742013009694	tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815
742013009695	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
742013009696	FMN binding site [chemical binding]; other site
742013009697	active site
742013009698	catalytic residues [active]
742013009699	substrate binding site [chemical binding]; other site
742013009700	Poly-beta-hydroxyalkanoate depolymerase [Lipid metabolism]; Region: DepA; COG4553
742013009701	PHB de-polymerase C-terminus; Region: PHB_depo_C; pfam06850
742013009702	Putative Fe-S cluster; Region: FeS; cl17515
742013009703	4Fe-4S binding domain; Region: Fer4; pfam00037
742013009704	4Fe-4S dicluster domain; Region: Fer4_10; pfam13237
742013009705	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
742013009706	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
742013009707	dimer interface [polypeptide binding]; other site
742013009708	putative CheW interface [polypeptide binding]; other site
742013009709	succinyldiaminopimelate transaminase; Provisional; Region: PRK09147
742013009710	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
742013009711	pyridoxal 5'-phosphate binding site [chemical binding]; other site
742013009712	homodimer interface [polypeptide binding]; other site
742013009713	catalytic residue [active]
742013009714	2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830
742013009715	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350
742013009716	active site
742013009717	substrate binding site [chemical binding]; other site
742013009718	trimer interface [polypeptide binding]; other site
742013009719	CoA binding site [chemical binding]; other site
742013009720	Tfp pilus assembly protein, ATPase PilU [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilU; COG5008
742013009721	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
742013009722	ATP binding site [chemical binding]; other site
742013009723	Walker B motif; other site
742013009724	succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009
742013009725	M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891
742013009726	metal binding site [ion binding]; metal-binding site
742013009727	dimer interface [polypeptide binding]; other site
742013009728	Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis]; Region: HemK; COG2890
742013009729	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
742013009730	S-adenosylmethionine binding site [chemical binding]; other site
742013009731	Transcriptional regulator [Transcription]; Region: LysR; COG0583
742013009732	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
742013009733	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
742013009734	dimerization interface [polypeptide binding]; other site
742013009735	acyl-CoA synthetase; Validated; Region: PRK06188
742013009736	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
742013009737	Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929
742013009738	acyl-activating enzyme (AAE) consensus motif; other site
742013009739	putative AMP binding site [chemical binding]; other site
742013009740	putative active site [active]
742013009741	putative CoA binding site [chemical binding]; other site
742013009742	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
742013009743	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
742013009744	active site
742013009745	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
742013009746	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
742013009747	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
742013009748	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
742013009749	ABC transporter; Region: ABC_tran_2; pfam12848
742013009750	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
742013009751	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
742013009752	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
742013009753	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
742013009754	putative active site [active]
742013009755	lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096
742013009756	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
742013009757	substrate binding pocket [chemical binding]; other site
742013009758	membrane-bound complex binding site; other site
742013009759	hinge residues; other site
742013009760	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
742013009761	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
742013009762	dimer interface [polypeptide binding]; other site
742013009763	ABC-ATPase subunit interface; other site
742013009764	putative PBP binding loops; other site
742013009765	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
742013009766	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
742013009767	dimer interface [polypeptide binding]; other site
742013009768	conserved gate region; other site
742013009769	putative PBP binding loops; other site
742013009770	ABC-ATPase subunit interface; other site
742013009771	L-Asparaginase type 2. L-Asparaginase hydrolyzes L-asparagine to L-aspartate and ammonia. The proenzyme undergoes an autoproteolytic cleavage into alpha and beta subunits to expose a threonine residue which becomes the N-terminal residue of the beta...; Region: Asparaginase_2; cd04701
742013009772	catalytic nucleophile [active]
742013009773	acetyacetyl-CoA reductase; Provisional; Region: PRK12938
742013009774	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
742013009775	NAD(P) binding site [chemical binding]; other site
742013009776	homotetramer interface [polypeptide binding]; other site
742013009777	homodimer interface [polypeptide binding]; other site
742013009778	active site
742013009779	putative acyltransferase; Provisional; Region: PRK05790
742013009780	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
742013009781	dimer interface [polypeptide binding]; other site
742013009782	active site
742013009783	poly(R)-hydroxyalkanoic acid synthase, class I; Region: PHA_synth_I; TIGR01838
742013009784	Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167
742013009785	Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496
742013009786	Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; cl00650
742013009787	GST_N family, Class Zeta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Zeta; cd03042
742013009788	maleylacetoacetate isomerase; Region: maiA; TIGR01262
742013009789	C-terminal domain interface [polypeptide binding]; other site
742013009790	GSH binding site (G-site) [chemical binding]; other site
742013009791	putative dimer interface [polypeptide binding]; other site
742013009792	C-terminal, alpha helical domain of Class Zeta Glutathione S-transferases; Region: GST_C_Zeta; cd03191
742013009793	dimer interface [polypeptide binding]; other site
742013009794	N-terminal domain interface [polypeptide binding]; other site
742013009795	maleylacetoacetate (MAA) substrate binding site (H site) [chemical binding]; other site
742013009796	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
742013009797	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
742013009798	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_4; cd04511
742013009799	nudix motif; other site
742013009800	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cd00588
742013009801	hypothetical protein; Provisional; Region: PRK10279
742013009802	Bacterial patatin-like phospholipase domain containing protein 6; Region: Pat_NTE_like_bacteria; cd07228
742013009803	active site
742013009804	nucleophile elbow; other site
742013009805	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
742013009806	NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956
742013009807	nucleotide binding pocket [chemical binding]; other site
742013009808	K-X-D-G motif; other site
742013009809	catalytic site [active]
742013009810	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
742013009811	NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119
742013009812	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786
742013009813	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
742013009814	Dimer interface [polypeptide binding]; other site
742013009815	BRCT sequence motif; other site
742013009816	ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic...; Region: ZipA; cl12038
742013009817	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
742013009818	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
742013009819	Walker A/P-loop; other site
742013009820	ATP binding site [chemical binding]; other site
742013009821	Q-loop/lid; other site
742013009822	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
742013009823	ABC transporter signature motif; other site
742013009824	Walker B; other site
742013009825	D-loop; other site
742013009826	H-loop/switch region; other site
742013009827	CHASE domain; Region: CHASE; pfam03924
742013009828	PAS domain S-box; Region: sensory_box; TIGR00229
742013009829	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
742013009830	putative active site [active]
742013009831	heme pocket [chemical binding]; other site
742013009832	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
742013009833	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
742013009834	metal binding site [ion binding]; metal-binding site
742013009835	active site
742013009836	I-site; other site
742013009837	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
742013009838	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
742013009839	2-methylisocitrate dehydratase, Fe/S-dependent; Region: 2met_isocit_dHY; TIGR02333
742013009840	Aconitase A catalytic domain; Region: AcnA_IRP; cd01586
742013009841	substrate binding site [chemical binding]; other site
742013009842	ligand binding site [chemical binding]; other site
742013009843	Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215
742013009844	substrate binding site [chemical binding]; other site
742013009845	probable AcnD-accessory protein PrpF; Region: prpF; TIGR02334
742013009846	Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342
742013009847	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
742013009848	catalytic residue [active]
742013009849	Transcriptional regulator [Transcription]; Region: LysR; COG0583
742013009850	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
742013009851	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
742013009852	putative effector binding pocket; other site
742013009853	dimerization interface [polypeptide binding]; other site
742013009854	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
742013009855	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
742013009856	Propionate catabolism activator; Region: PrpR_N; pfam06506
742013009857	PAS domain; Region: PAS; smart00091
742013009858	PAS fold; Region: PAS; pfam00989
742013009859	psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974
742013009860	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
742013009861	Walker A motif; other site
742013009862	ATP binding site [chemical binding]; other site
742013009863	Walker B motif; other site
742013009864	arginine finger; other site
742013009865	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
742013009866	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
742013009867	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
742013009868	Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714
742013009869	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
742013009870	tetramer interface [polypeptide binding]; other site
742013009871	active site
742013009872	Mg2+/Mn2+ binding site [ion binding]; other site
742013009873	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
742013009874	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
742013009875	Transcriptional regulator [Transcription]; Region: LysR; COG0583
742013009876	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
742013009877	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
742013009878	dimerization interface [polypeptide binding]; other site
742013009879	methyl viologen resistance protein SmvA; Provisional; Region: PRK14995
742013009880	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
742013009881	putative substrate translocation pore; other site
742013009882	superoxide dismutase; Provisional; Region: PRK10543
742013009883	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
742013009884	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
742013009885	exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286
742013009886	ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489
742013009887	generic binding surface II; other site
742013009888	generic binding surface I; other site
742013009889	Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811
742013009890	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
742013009891	Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472
742013009892	tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652
742013009893	Uncharacterized conserved protein [Function unknown]; Region: COG2835
742013009894	3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450
742013009895	CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517
742013009896	Ligand binding site; other site
742013009897	oligomer interface; other site
742013009898	adenylate kinase; Reviewed; Region: adk; PRK00279
742013009899	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
742013009900	AMP-binding site [chemical binding]; other site
742013009901	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
742013009902	Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964
742013009903	active site
742013009904	homotetramer interface [polypeptide binding]; other site
742013009905	homodimer interface [polypeptide binding]; other site
742013009906	LexA repressor; Validated; Region: PRK00215
742013009907	LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726
742013009908	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
742013009909	Catalytic site [active]
742013009910	RNA polymerase sigma factor FecI; Provisional; Region: PRK09651
742013009911	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
742013009912	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
742013009913	DNA binding residues [nucleotide binding]
742013009914	fec operon regulator FecR; Reviewed; Region: PRK09774
742013009915	FecR protein; Region: FecR; pfam04773
742013009916	AAA domain; Region: AAA_33; pfam13671
742013009917	AAA domain; Region: AAA_17; pfam13207
742013009918	CrcB-like protein; Region: CRCB; cl09114
742013009919	lysozyme_like domain.  This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222
742013009920	catalytic residue [active]
742013009921	Phage holin family 6; Region: Phage_holin_6; cl17609
742013009922	inosine-5'-monophosphate dehydrogenase; Provisional; Region: PTZ00314
742013009923	Excalibur calcium-binding domain; Region: Excalibur; pfam05901
742013009924	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
742013009925	RecT family; Region: RecT; cl04285
742013009926	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
742013009927	DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847
742013009928	active site
742013009929	catalytic site [active]
742013009930	substrate binding site [chemical binding]; other site
742013009931	H-NS histone family; Region: Histone_HNS; pfam00816
742013009932	Domain in histone-like proteins of HNS family; Region: HNS; smart00528
742013009933	Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; cl17523
742013009934	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
742013009935	active site
742013009936	DNA binding site [nucleotide binding]
742013009937	Int/Topo IB signature motif; other site
742013009938	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
742013009939	Putative D-3-Phosphoglycerate Dehydrogenases; Region: PGDH_like_1; cd12169
742013009940	dimerization interface [polypeptide binding]; other site
742013009941	NAD binding site [chemical binding]; other site
742013009942	ligand binding site [chemical binding]; other site
742013009943	catalytic site [active]
742013009944	DNA polymerase III chi subunit, HolC; Region: DNA_pol3_chi; pfam04364
742013009945	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
742013009946	multifunctional aminopeptidase A; Provisional; Region: PRK00913
742013009947	interface (dimer of trimers) [polypeptide binding]; other site
742013009948	Substrate-binding/catalytic site; other site
742013009949	Zn-binding sites [ion binding]; other site
742013009950	Predicted permeases [General function prediction only]; Region: COG0795
742013009951	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
742013009952	Predicted permeases [General function prediction only]; Region: COG0795; cl12074
742013009953	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
742013009954	Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416
742013009955	putative active site [active]
742013009956	transcriptional regulator CysB-like protein; Reviewed; Region: PRK12682
742013009957	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
742013009958	The C-terminal substrate domain of LysR-type transcriptional regulators CysB-like contains type 2 periplasmic binding fold; Region: PBP2_CysB_like; cd08413
742013009959	substrate binding site [chemical binding]; other site
742013009960	dimerization interface [polypeptide binding]; other site
742013009961	methionine aminotransferase; Validated; Region: PRK09082
742013009962	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
742013009963	pyridoxal 5'-phosphate binding site [chemical binding]; other site
742013009964	homodimer interface [polypeptide binding]; other site
742013009965	catalytic residue [active]
742013009966	Tannase and feruloyl esterase; Region: Tannase; pfam07519
742013009967	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
742013009968	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
742013009969	Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion transport and metabolism]; Region: FhuE; COG4773
742013009970	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
742013009971	N-terminal plug; other site
742013009972	ligand-binding site [chemical binding]; other site
742013009973	siderophore transporter, RhtX/FptX family; Region: sider_RhtX_FptX; TIGR02718
742013009974	Acetyl-coenzyme A transporter 1; Region: Acatn; pfam13000
742013009975	Cupin domain; Region: Cupin_2; cl17218
742013009976	Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion transport and metabolism]; Region: FhuE; COG4773
742013009977	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
742013009978	N-terminal plug; other site
742013009979	ligand-binding site [chemical binding]; other site
742013009980	Helix-turn-helix domain; Region: HTH_18; pfam12833
742013009981	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
742013009982	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
742013009983	2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654
742013009984	ribonuclease G; Provisional; Region: PRK11712
742013009985	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
742013009986	homodimer interface [polypeptide binding]; other site
742013009987	oligonucleotide binding site [chemical binding]; other site
742013009988	Maf-like protein; Region: Maf; pfam02545
742013009989	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
742013009990	active site
742013009991	dimer interface [polypeptide binding]; other site
742013009992	rRNA large subunit methyltransferase; Provisional; Region: PRK00103
742013009993	iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090
742013009994	Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218
742013009995	coproporphyrinogen III oxidase; Provisional; Region: PRK05330
742013009996	phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885
742013009997	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
742013009998	Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071
742013009999	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
742013010000	hypothetical protein; Validated; Region: PRK00110
742013010001	Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872
742013010002	Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171
742013010003	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
742013010004	tetramer interface [polypeptide binding]; other site
742013010005	pyridoxal 5'-phosphate binding site [chemical binding]; other site
742013010006	catalytic residue [active]
742013010007	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
742013010008	active site
742013010009	hypothetical protein; Provisional; Region: PRK12378
742013010010	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
742013010011	Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618
742013010012	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
742013010013	active site
742013010014	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
742013010015	CoA-transferase family III; Region: CoA_transf_3; pfam02515
742013010016	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
742013010017	Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301
742013010018	Transcriptional regulator [Transcription]; Region: LysR; COG0583
742013010019	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
742013010020	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_2; cd08427
742013010021	putative dimerization interface [polypeptide binding]; other site
742013010022	DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906
742013010023	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
742013010024	The C-terminal substrate binding domain of LysR-type transcrptional regulator BudR, which is responsible for activation of the expression of the butanediol operon genes; contains the type 2 periplasmic binding fold; Region: PBP2_BudR; cd08451
742013010025	putative dimerization interface [polypeptide binding]; other site
742013010026	putative substrate binding pocket [chemical binding]; other site
742013010027	Trans-aconitate methyltransferase [General function prediction only]; Region: Tam; COG4106
742013010028	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
742013010029	S-adenosylmethionine binding site [chemical binding]; other site
742013010030	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
742013010031	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263
742013010032	Uncharacterized membrane protein, required for spore maturation in B.subtilis. [General function prediction only]; Region: SpmA; COG2715
742013010033	Uncharacterized membrane protein [Function unknown]; Region: SpmB; COG0700
742013010034	RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966
742013010035	metal binding triad [ion binding]; metal-binding site
742013010036	Uncharacterized conserved protein [Function unknown]; Region: COG2361
742013010037	exonuclease I; Provisional; Region: sbcB; PRK11779
742013010038	N-terminal DEDDh 3'-5' exonuclease domain of Escherichia coli exonuclease I and similar proteins; Region: ExoI_N; cd06138
742013010039	active site
742013010040	catalytic site [active]
742013010041	substrate binding site [chemical binding]; other site
742013010042	Exonuclease C-terminal; Region: Exonuc_X-T_C; pfam08411
742013010043	cardiolipin synthetase; Reviewed; Region: cls; PRK01642
742013010044	Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110
742013010045	putative active site [active]
742013010046	catalytic site [active]
742013010047	catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112
742013010048	putative active site [active]
742013010049	catalytic site [active]
742013010050	ATP-dependent Clp protease ATP-binding subunit clpA; Region: ClpA; TIGR02639
742013010051	Clp amino terminal domain; Region: Clp_N; pfam02861
742013010052	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
742013010053	Walker A motif; other site
742013010054	ATP binding site [chemical binding]; other site
742013010055	Walker B motif; other site
742013010056	arginine finger; other site
742013010057	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
742013010058	Walker A motif; other site
742013010059	ATP binding site [chemical binding]; other site
742013010060	Walker B motif; other site
742013010061	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
742013010062	Uncharacterized conserved protein [Function unknown]; Region: COG2127
742013010063	DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673
742013010064	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433
742013010065	putative active site [active]
742013010066	putative PHP Thumb interface [polypeptide binding]; other site
742013010067	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
742013010068	generic binding surface II; other site
742013010069	generic binding surface I; other site
742013010070	outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302
742013010071	Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199
742013010072	CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cl17460
742013010073	DEAD_2; Region: DEAD_2; pfam06733
742013010074	Helicase C-terminal domain; Region: Helicase_C_2; pfam13307
742013010075	Serine/threonine protein phosphatase [Signal transduction mechanisms]; Region: PTC1; COG0631
742013010076	active site
742013010077	Predicted ATPase [General function prediction only]; Region: COG1485
742013010078	dihydrolipoamide dehydrogenase; Validated; Region: PRK06327
742013010079	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
742013010080	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
742013010081	dihydrolipoamide succinyltransferase; Validated; Region: PRK05704
742013010082	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
742013010083	E3 interaction surface; other site
742013010084	lipoyl attachment site [posttranslational modification]; other site
742013010085	e3 binding domain; Region: E3_binding; pfam02817
742013010086	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
742013010087	2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404
742013010088	Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016
742013010089	TPP-binding site [chemical binding]; other site
742013010090	Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779
742013010091	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
742013010092	Domain of unknown function DUF20; Region: UPF0118; pfam01594
742013010093	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
742013010094	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
742013010095	molybdopterin cofactor binding site; other site
742013010096	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
742013010097	Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792
742013010098	molybdopterin cofactor binding site; other site
742013010099	formate dehydrogenase, beta subunit, Fe-S containing; Region: FDH-beta; TIGR01582
742013010100	Formate dehydrogenase N, transmembrane; Region: Form-deh_trans; pfam09163
742013010101	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859
742013010102	formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583
742013010103	formate dehydrogenase accessory protein FdhE; Region: FdhE; TIGR01562
742013010104	Protein involved in formate dehydrogenase formation; Region: FdhE; pfam04216
742013010105	selenocysteine synthase; Provisional; Region: PRK04311
742013010106	Selenocysteine synthase [seryl-tRNASer selenium transferase] [Amino acid transport and metabolism]; Region: SelA; COG1921
742013010107	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
742013010108	catalytic residue [active]
742013010109	selenocysteinyl-tRNA-specific translation factor; Provisional; Region: PRK10512
742013010110	SelB, the dedicated elongation factor for delivery of selenocysteinyl-tRNA to the ribosome; Region: SelB; cd04171
742013010111	G1 box; other site
742013010112	putative GEF interaction site [polypeptide binding]; other site
742013010113	GTP/Mg2+ binding site [chemical binding]; other site
742013010114	Switch I region; other site
742013010115	G2 box; other site
742013010116	G3 box; other site
742013010117	Switch II region; other site
742013010118	G4 box; other site
742013010119	G5 box; other site
742013010120	selB_II: this subfamily represents the domain of elongation factor SelB, homologous to domain II of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several...; Region: selB_II; cd03696
742013010121	This family represents the domain of elongation factor SelB, homologous to domain III of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several elements:...; Region: selB_III; cd04094
742013010122	Elongation factor SelB, winged helix; Region: SelB-wing_2; pfam09106
742013010123	Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107
742013010124	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
742013010125	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
742013010126	ligand binding site [chemical binding]; other site
742013010127	HAMP domain; Region: HAMP; pfam00672
742013010128	dimerization interface [polypeptide binding]; other site
742013010129	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
742013010130	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
742013010131	metal binding site [ion binding]; metal-binding site
742013010132	active site
742013010133	I-site; other site
742013010134	Domain of unknown function (DUF4154); Region: DUF4154; pfam13689
742013010135	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
742013010136	Coenzyme A binding pocket [chemical binding]; other site
742013010137	selenophosphate synthetase; Provisional; Region: PRK00943
742013010138	Selenophosphate synthetase  (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195
742013010139	dimerization interface [polypeptide binding]; other site
742013010140	putative ATP binding site [chemical binding]; other site
742013010141	Penicillin amidase; Region: Penicil_amidase; pfam01804
742013010142	The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid.  N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467
742013010143	The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid.  N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467
742013010144	active site
742013010145	The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid.  N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467
742013010146	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
742013010147	AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404
742013010148	putative DNA binding site [nucleotide binding]; other site
742013010149	putative Zn2+ binding site [ion binding]; other site
742013010150	AsnC family; Region: AsnC_trans_reg; pfam01037
742013010151	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
742013010152	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
742013010153	metal binding site [ion binding]; metal-binding site
742013010154	active site
742013010155	I-site; other site
742013010156	Cache domain; Region: Cache_1; pfam02743
742013010157	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
742013010158	dimerization interface [polypeptide binding]; other site
742013010159	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
742013010160	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
742013010161	dimer interface [polypeptide binding]; other site
742013010162	putative CheW interface [polypeptide binding]; other site
742013010163	H-NS histone family; Region: Histone_HNS; pfam00816
742013010164	Domain in histone-like proteins of HNS family; Region: HNS; smart00528
742013010165	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
742013010166	dimerization interface [polypeptide binding]; other site
742013010167	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
742013010168	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
742013010169	dimer interface [polypeptide binding]; other site
742013010170	putative CheW interface [polypeptide binding]; other site
742013010171	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
742013010172	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
742013010173	metal binding site [ion binding]; metal-binding site
742013010174	active site
742013010175	I-site; other site
742013010176	CsbD-like; Region: CsbD; pfam05532
742013010177	Arc-like DNA binding domain; Region: Arc; pfam03869
742013010178	This domain family includes the Enolpyruvate transferase (EPT) family and the RNA 3' phosphate cyclase family (RTPC). These 2 families differ in that EPT is formed by 3 repeats of an alpha-beta structural domain while  RTPC has 3 similar repeats...; Region: EPT_RTPC-like; cl00288
742013010179	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
742013010180	putative active site [active]
742013010181	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
742013010182	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
742013010183	Coenzyme A binding pocket [chemical binding]; other site
742013010184	Choloylglycine hydrolase (CGH) is a bile salt-modifying enzyme that hydrolyzes non-peptide carbon-nitrogen bonds in choloylglycine and choloyltaurine, both of which are present in bile.  CGH is present in a number of probiotic microbial organisms that...; Region: Ntn_CGH; cd01902
742013010185	Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275
742013010186	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
742013010187	IPTL-CTERM protein sorting domain; Region: IPTL_CTERM; TIGR04174
742013010188	Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823
742013010189	BON domain; Region: BON; pfam04972
742013010190	BON domain; Region: BON; pfam04972
742013010191	PRC-barrel domain; Region: PRC; pfam05239
742013010192	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
742013010193	DNA binding site [nucleotide binding]
742013010194	active site
742013010195	Int/Topo IB signature motif; other site
742013010196	Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179
742013010197	Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755
742013010198	putative ATP binding site [chemical binding]; other site
742013010199	putative substrate interface [chemical binding]; other site
742013010200	tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795
742013010201	Tetratricopeptide repeat; Region: TPR_6; pfam13174
742013010202	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
742013010203	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
742013010204	ligand binding site [chemical binding]; other site
742013010205	translocation protein TolB; Provisional; Region: tolB; PRK02889
742013010206	TolB amino-terminal domain; Region: TolB_N; pfam04052
742013010207	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
742013010208	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
742013010209	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
742013010210	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
742013010211	lipid A export permease/ATP-binding protein MsbA; Region: MsbA_lipidA; TIGR02203
742013010212	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
742013010213	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
742013010214	Walker A/P-loop; other site
742013010215	ATP binding site [chemical binding]; other site
742013010216	Q-loop/lid; other site
742013010217	ABC transporter signature motif; other site
742013010218	Walker B; other site
742013010219	D-loop; other site
742013010220	H-loop/switch region; other site
742013010221	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
742013010222	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
742013010223	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
742013010224	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
742013010225	active site
742013010226	PilZ domain; Region: PilZ; cl01260
742013010227	DNA polymerase III subunit delta'; Validated; Region: PRK06964
742013010228	DNA polymerase III subunit delta'; Validated; Region: PRK08485
742013010229	thymidylate kinase; Validated; Region: tmk; PRK00698
742013010230	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
742013010231	TMP-binding site; other site
742013010232	ATP-binding site [chemical binding]; other site
742013010233	YceG-like family; Region: YceG; pfam02618
742013010234	proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010
742013010235	dimerization interface [polypeptide binding]; other site
742013010236	Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354
742013010237	folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317
742013010238	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
742013010239	active site
742013010240	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
742013010241	Coenzyme A binding pocket [chemical binding]; other site
742013010242	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
742013010243	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
742013010244	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
742013010245	Iron-containing alcohol dehydrogenases-like, involved in the linear alkylbenzenesulfonate (LAS) degradation pathway; Region: Fe-ADH7; cd08192
742013010246	putative active site [active]
742013010247	metal binding site [ion binding]; metal-binding site
742013010248	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
742013010249	Domain of unknown function DUF20; Region: UPF0118; pfam01594
742013010250	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
742013010251	GAF domain; Region: GAF; pfam01590
742013010252	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
742013010253	ATP binding site [chemical binding]; other site
742013010254	Mg2+ binding site [ion binding]; other site
742013010255	G-X-G motif; other site
742013010256	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
742013010257	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
742013010258	active site
742013010259	phosphorylation site [posttranslational modification]
742013010260	intermolecular recognition site; other site
742013010261	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
742013010262	DNA binding residues [nucleotide binding]
742013010263	dimerization interface [polypeptide binding]; other site
742013010264	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
742013010265	Domain of unknown function (DUF4384); Region: DUF4384; pfam14326
742013010266	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
742013010267	Sel1-like repeats; Region: SEL1; smart00671
742013010268	HDOD domain; Region: HDOD; pfam08668
742013010269	Transcriptional accessory protein [Transcription]; Region: Tex; COG2183
742013010270	Tex-like protein N-terminal domain; Region: Tex_N; pfam09371
742013010271	Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732
742013010272	S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685
742013010273	RNA binding site [nucleotide binding]; other site
742013010274	Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132
742013010275	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
742013010276	Multicopper oxidase; Region: Cu-oxidase; pfam00394
742013010277	Multicopper oxidase; Region: Cu-oxidase_2; pfam07731
742013010278	Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell division and chromosome partitioning / Cytoskeleton]; Region: ATS1; COG5184
742013010279	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540
742013010280	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
742013010281	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540
742013010282	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540
742013010283	Protein of unknown function DUF72; Region: DUF72; pfam01904
742013010284	Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329
742013010285	copper/silver efflux system outer membrane protein CusC; Provisional; Region: PRK09837
742013010286	The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915
742013010287	Protein export membrane protein; Region: SecD_SecF; cl14618
742013010288	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
742013010289	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
742013010290	HlyD family secretion protein; Region: HlyD_3; pfam13437
742013010291	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
742013010292	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
742013010293	putative substrate translocation pore; other site
742013010294	drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710
742013010295	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
742013010296	putative substrate translocation pore; other site
742013010297	Protein of unknown function (DUF1566); Region: DUF1566; pfam07603
742013010298	hypothetical protein; Provisional; Region: PRK06194
742013010299	classical (c) SDRs; Region: SDR_c; cd05233
742013010300	NAD(P) binding site [chemical binding]; other site
742013010301	active site
742013010302	Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130
742013010303	Prostaglandin dehydrogenases; Region: PGDH; cd05288
742013010304	NAD(P) binding site [chemical binding]; other site
742013010305	substrate binding site [chemical binding]; other site
742013010306	dimer interface [polypeptide binding]; other site
742013010307	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
742013010308	CoenzymeA binding site [chemical binding]; other site
742013010309	subunit interaction site [polypeptide binding]; other site
742013010310	PHB binding site; other site
742013010311	gluconate 5-dehydrogenase; Provisional; Region: PRK08213
742013010312	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
742013010313	NAD(P) binding site [chemical binding]; other site
742013010314	active site
742013010315	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
742013010316	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
742013010317	DNA binding site [nucleotide binding]
742013010318	active site
742013010319	S-adenosylmethionine-dependent methyltransferase; Region: Methyltrans_SAM; pfam10672
742013010320	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
742013010321	S-adenosylmethionine binding site [chemical binding]; other site
742013010322	enolase; Provisional; Region: eno; PRK00077
742013010323	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
742013010324	dimer interface [polypeptide binding]; other site
742013010325	metal binding site [ion binding]; metal-binding site
742013010326	substrate binding pocket [chemical binding]; other site
742013010327	Transcriptional regulator [Transcription]; Region: LysR; COG0583
742013010328	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
742013010329	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
742013010330	dimerization interface [polypeptide binding]; other site
742013010331	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
742013010332	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
742013010333	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
742013010334	PQQ-dependent dehydrogenase, methanol/ethanol family; Region: PQQ_enz_alc_DH; TIGR03075
742013010335	PQQ_like domain of the quinohemoprotein alcohol dehydrogenase (type II); Region: PQQ_ADH_II; cd10279
742013010336	Trp docking motif [polypeptide binding]; other site
742013010337	cytochrome domain interface [polypeptide binding]; other site
742013010338	active site
742013010339	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
742013010340	Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; pfam13557
742013010341	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
742013010342	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
742013010343	NAD(P) binding site [chemical binding]; other site
742013010344	catalytic residues [active]
742013010345	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
742013010346	Predicted transcriptional regulator [Transcription]; Region: COG3636; cl17681
742013010347	D-lactate dehydrogenase; Provisional; Region: PRK11183
742013010348	FAD binding domain; Region: FAD_binding_4; pfam01565
742013010349	D-lactate dehydrogenase, membrane binding; Region: Lact-deh-memb; pfam09330
742013010350	L-lactate dehydrogenase; Provisional; Region: lldD; PRK11197
742013010351	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
742013010352	phosphate binding site [ion binding]; other site
742013010353	DNA-binding transcriptional repressor LldR; Provisional; Region: PRK10421
742013010354	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
742013010355	DNA-binding site [nucleotide binding]; DNA binding site
742013010356	FCD domain; Region: FCD; pfam07729
742013010357	L-lactate permease; Provisional; Region: PRK10420
742013010358	glycolate transporter; Provisional; Region: PRK09695
742013010359	cell density-dependent motility repressor; Provisional; Region: PRK10082
742013010360	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
742013010361	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
742013010362	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
742013010363	inhibitor site; inhibition site
742013010364	active site
742013010365	dimer interface [polypeptide binding]; other site
742013010366	catalytic residue [active]
742013010367	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
742013010368	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK12825
742013010369	classical (c) SDRs; Region: SDR_c; cd05233
742013010370	NAD(P) binding site [chemical binding]; other site
742013010371	active site
742013010372	L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948
742013010373	Mandelate racemase (MR)-like subfamily of the enolase superfamily, subgroup 1. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic...; Region: MR_like_1; cd03326
742013010374	putative active site pocket [active]
742013010375	metal binding site [ion binding]; metal-binding site
742013010376	ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974
742013010377	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
742013010378	substrate binding pocket [chemical binding]; other site
742013010379	membrane-bound complex binding site; other site
742013010380	hinge residues; other site
742013010381	ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638
742013010382	ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256
742013010383	Walker A/P-loop; other site
742013010384	ATP binding site [chemical binding]; other site
742013010385	Q-loop/lid; other site
742013010386	ABC transporter signature motif; other site
742013010387	Walker B; other site
742013010388	D-loop; other site
742013010389	H-loop/switch region; other site
742013010390	phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097
742013010391	phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097
742013010392	Transcriptional regulator [Transcription]; Region: LysR; COG0583
742013010393	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
742013010394	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
742013010395	putative effector binding pocket; other site
742013010396	dimerization interface [polypeptide binding]; other site
742013010397	EamA-like transporter family; Region: EamA; pfam00892
742013010398	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
742013010399	amidase catalytic site [active]
742013010400	Zn binding residues [ion binding]; other site
742013010401	substrate binding site [chemical binding]; other site
742013010402	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
742013010403	binding surface
742013010404	TPR motif; other site
742013010405	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
742013010406	Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655
742013010407	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
742013010408	Transcriptional regulator [Transcription]; Region: LysR; COG0583
742013010409	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
742013010410	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_1; cd08460
742013010411	putative substrate binding pocket [chemical binding]; other site
742013010412	putative dimerization interface [polypeptide binding]; other site
742013010413	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
742013010414	putative substrate translocation pore; other site
742013010415	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
742013010416	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
742013010417	N-terminal plug; other site
742013010418	ligand-binding site [chemical binding]; other site
742013010419	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
742013010420	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
742013010421	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
742013010422	DNA binding residues [nucleotide binding]
742013010423	Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712
742013010424	FecR protein; Region: FecR; pfam04773
742013010425	Transcriptional regulator [Transcription]; Region: LysR; COG0583
742013010426	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
742013010427	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_2; cd08471
742013010428	putative effector binding pocket; other site
742013010429	putative dimerization interface [polypeptide binding]; other site
742013010430	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
742013010431	GST_N family, unknown subfamily 4; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_4; cd03056
742013010432	putative C-terminal domain interface [polypeptide binding]; other site
742013010433	putative GSH binding site (G-site) [chemical binding]; other site
742013010434	putative dimer interface [polypeptide binding]; other site
742013010435	C-terminal, alpha helical domain of an unknown subfamily 7 of Glutathione S-transferases; Region: GST_C_7; cd03206
742013010436	putative N-terminal domain interface [polypeptide binding]; other site
742013010437	putative dimer interface [polypeptide binding]; other site
742013010438	putative substrate binding pocket (H-site) [chemical binding]; other site
742013010439	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
742013010440	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
742013010441	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
742013010442	FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184
742013010443	FAD binding pocket [chemical binding]; other site
742013010444	FAD binding motif [chemical binding]; other site
742013010445	phosphate binding motif [ion binding]; other site
742013010446	beta-alpha-beta structure motif; other site
742013010447	NAD binding pocket [chemical binding]; other site
742013010448	Heme binding  pocket [chemical binding]; other site
742013010449	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
742013010450	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
742013010451	catalytic loop [active]
742013010452	iron binding site [ion binding]; other site
742013010453	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
742013010454	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
742013010455	Coenzyme A binding pocket [chemical binding]; other site
742013010456	acyl-CoA dehydrogenase; Provisional; Region: PTZ00456
742013010457	Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418
742013010458	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
742013010459	active site
742013010460	Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806
742013010461	acetyl-CoA acetyltransferase; Provisional; Region: PRK07108
742013010462	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
742013010463	dimer interface [polypeptide binding]; other site
742013010464	active site
742013010465	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
742013010466	multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154
742013010467	substrate binding site [chemical binding]; other site
742013010468	oxyanion hole (OAH) forming residues; other site
742013010469	trimer interface [polypeptide binding]; other site
742013010470	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
742013010471	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
742013010472	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
742013010473	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
742013010474	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
742013010475	Walker A/P-loop; other site
742013010476	ATP binding site [chemical binding]; other site
742013010477	Q-loop/lid; other site
742013010478	ABC transporter signature motif; other site
742013010479	Walker B; other site
742013010480	D-loop; other site
742013010481	H-loop/switch region; other site
742013010482	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
742013010483	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
742013010484	Walker A/P-loop; other site
742013010485	ATP binding site [chemical binding]; other site
742013010486	Q-loop/lid; other site
742013010487	ABC transporter signature motif; other site
742013010488	Walker B; other site
742013010489	D-loop; other site
742013010490	H-loop/switch region; other site
742013010491	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
742013010492	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
742013010493	TM-ABC transporter signature motif; other site
742013010494	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
742013010495	TM-ABC transporter signature motif; other site
742013010496	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
742013010497	Periplasmic solute-binding domain of active transport proteins; Region: PBP1_SBP_like_3; cd06329
742013010498	putative ligand binding site [chemical binding]; other site
742013010499	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
742013010500	Periplasmic solute-binding domain of active transport proteins; Region: PBP1_SBP_like_3; cd06329
742013010501	putative ligand binding site [chemical binding]; other site
742013010502	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07008
742013010503	Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; Region: ttLC_FACS_AlkK_like; cd12119
742013010504	dimer interface [polypeptide binding]; other site
742013010505	acyl-activating enzyme (AAE) consensus motif; other site
742013010506	putative active site [active]
742013010507	AMP binding site [chemical binding]; other site
742013010508	putative CoA binding site [chemical binding]; other site
742013010509	Predicted acyl esterases [General function prediction only]; Region: COG2936
742013010510	X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; pfam08530
742013010511	Carboxylesterase family; Region: COesterase; pfam00135
742013010512	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
742013010513	substrate binding pocket [chemical binding]; other site
742013010514	catalytic triad [active]
742013010515	Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625
742013010516	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
742013010517	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
742013010518	Uncharacterized conserved protein [Function unknown]; Region: COG0397
742013010519	hypothetical protein; Validated; Region: PRK00029
742013010520	methionine sulfoxide reductase B; Provisional; Region: PRK00222
742013010521	SelR domain; Region: SelR; pfam01641
742013010522	intracellular septation protein A; Reviewed; Region: PRK00259
742013010523	Stress-induced morphogen (activity unknown) [Signal transduction mechanisms]; Region: BolA; COG0271
742013010524	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
742013010525	Outer membrane receptor for monomeric catechols [Inorganic ion transport and metabolism]; Region: Fiu; COG4774
742013010526	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
742013010527	N-terminal plug; other site
742013010528	ligand-binding site [chemical binding]; other site
742013010529	Ankyrin repeats (many copies); Region: Ank_4; pfam13637
742013010530	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
742013010531	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
742013010532	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
742013010533	Bacterial SH3 domain; Region: SH3_4; pfam06347
742013010534	Bacterial SH3 domain; Region: SH3_3; pfam08239
742013010535	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
742013010536	dimer interface [polypeptide binding]; other site
742013010537	substrate binding site [chemical binding]; other site
742013010538	ATP binding site [chemical binding]; other site
742013010539	glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352
742013010540	ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565
742013010541	thiS-thiF/thiG interaction site; other site
742013010542	Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728
742013010543	ThiS interaction site; other site
742013010544	putative active site [active]
742013010545	tetramer interface [polypeptide binding]; other site
742013010546	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
742013010547	thiamine phosphate binding site [chemical binding]; other site
742013010548	active site
742013010549	pyrophosphate binding site [ion binding]; other site
742013010550	3-hydroxy-acyl-CoA dehydrogenase; Validated; Region: PRK08268
742013010551	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
742013010552	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
742013010553	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
742013010554	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
742013010555	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
742013010556	ligand binding site [chemical binding]; other site
742013010557	flexible hinge region; other site
742013010558	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320
742013010559	Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154
742013010560	Phosphotransferase enzyme family; Region: APH; pfam01636
742013010561	putative active site [active]
742013010562	putative substrate binding site [chemical binding]; other site
742013010563	ATP binding site [chemical binding]; other site
742013010564	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
742013010565	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
742013010566	active site
742013010567	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
742013010568	macrolide transporter ATP-binding /permease protein; Provisional; Region: PRK10535
742013010569	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
742013010570	Walker A/P-loop; other site
742013010571	ATP binding site [chemical binding]; other site
742013010572	Q-loop/lid; other site
742013010573	ABC transporter signature motif; other site
742013010574	Walker B; other site
742013010575	D-loop; other site
742013010576	H-loop/switch region; other site
742013010577	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
742013010578	FtsX-like permease family; Region: FtsX; pfam02687
742013010579	macrolide transporter subunit MacA; Provisional; Region: PRK11578
742013010580	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
742013010581	HlyD family secretion protein; Region: HlyD_3; pfam13437
742013010582	Protein of unknown function (DUF3325); Region: DUF3325; pfam11804
742013010583	Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182
742013010584	PepSY-associated TM helix; Region: PepSY_TM_3; pfam13706
742013010585	PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703
742013010586	Secretin and TonB N terminus short domain; Region: STN; smart00965
742013010587	Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion transport and metabolism]; Region: FhuE; COG4773
742013010588	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
742013010589	N-terminal plug; other site
742013010590	ligand-binding site [chemical binding]; other site
742013010591	RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985
742013010592	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
742013010593	DNA binding residues [nucleotide binding]
742013010594	Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712
742013010595	FecR protein; Region: FecR; pfam04773
742013010596	Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion transport and metabolism]; Region: FhuE; COG4773
742013010597	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
742013010598	N-terminal plug; other site
742013010599	ligand-binding site [chemical binding]; other site
742013010600	Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712
742013010601	FecR protein; Region: FecR; pfam04773
742013010602	RNA polymerase sigma factor; Provisional; Region: PRK12528
742013010603	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
742013010604	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
742013010605	DNA binding residues [nucleotide binding]
742013010606	Secretin and TonB N terminus short domain; Region: STN; smart00965
742013010607	Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion transport and metabolism]; Region: FhuE; COG4773
742013010608	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
742013010609	N-terminal plug; other site
742013010610	ligand-binding site [chemical binding]; other site
742013010611	fec operon regulator FecR; Reviewed; Region: PRK09774
742013010612	FecR protein; Region: FecR; pfam04773
742013010613	RNA polymerase sigma factor; Provisional; Region: PRK12528
742013010614	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
742013010615	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
742013010616	Secretin and TonB N terminus short domain; Region: STN; smart00965
742013010617	Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion transport and metabolism]; Region: FhuE; COG4773
742013010618	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
742013010619	N-terminal plug; other site
742013010620	ligand-binding site [chemical binding]; other site
742013010621	fec operon regulator FecR; Reviewed; Region: PRK09774
742013010622	FecR protein; Region: FecR; pfam04773
742013010623	RNA polymerase sigma factor; Provisional; Region: PRK12528
742013010624	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
742013010625	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
742013010626	DNA binding residues [nucleotide binding]
742013010627	Secretin and TonB N terminus short domain; Region: STN; smart00965
742013010628	ferrichrome outer membrane transporter; Provisional; Region: PRK10044
742013010629	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
742013010630	N-terminal plug; other site
742013010631	ligand-binding site [chemical binding]; other site
742013010632	Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712
742013010633	FecR protein; Region: FecR; pfam04773
742013010634	RNA polymerase sigma factor; Provisional; Region: PRK12528
742013010635	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
742013010636	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
742013010637	DNA binding residues [nucleotide binding]
742013010638	cyclic-di-GMP phosphodiesterase; Provisional; Region: PRK11359
742013010639	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
742013010640	putative active site [active]
742013010641	heme pocket [chemical binding]; other site
742013010642	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
742013010643	putative active site [active]
742013010644	heme pocket [chemical binding]; other site
742013010645	GAF domain; Region: GAF; cl17456
742013010646	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
742013010647	metal binding site [ion binding]; metal-binding site
742013010648	active site
742013010649	I-site; other site
742013010650	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
742013010651	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
742013010652	HAMP domain; Region: HAMP; pfam00672
742013010653	dimerization interface [polypeptide binding]; other site
742013010654	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
742013010655	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
742013010656	dimer interface [polypeptide binding]; other site
742013010657	putative CheW interface [polypeptide binding]; other site
742013010658	peptide chain release factor 2; Validated; Region: prfB; PRK00578
742013010659	This domain is found in peptide chain release factors; Region: PCRF; smart00937
742013010660	RF-1 domain; Region: RF-1; pfam00472
742013010661	aminopeptidase N; Provisional; Region: pepN; PRK14015
742013010662	Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600
742013010663	active site
742013010664	Zn binding site [ion binding]; other site
742013010665	Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate  into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354
742013010666	AMP binding site [chemical binding]; other site
742013010667	metal binding site [ion binding]; metal-binding site
742013010668	active site
742013010669	Transposase, Mutator family; Region: Transposase_mut; pfam00872
742013010670	MULE transposase domain; Region: MULE; pfam10551
742013010671	Uncharacterized ACR, COG2135; Region: DUF159; pfam02586
742013010672	Homeodomain-like domain; Region: HTH_23; cl17451
742013010673	Winged helix-turn helix; Region: HTH_29; pfam13551
742013010674	Integrase core domain; Region: rve; pfam00665
742013010675	Integrase core domain; Region: rve_3; pfam13683
742013010676	shikimate kinase; Reviewed; Region: aroK; PRK00131
742013010677	Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027
742013010678	ligand-binding site [chemical binding]; other site
742013010679	Aspartyl/Asparaginyl beta-hydroxylase; Region: Asp_Arg_Hydrox; cl17820
742013010680	Cupin domain; Region: Cupin_2; cl17218
742013010681	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
742013010682	EamA-like transporter family; Region: EamA; pfam00892
742013010683	GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518
742013010684	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741
742013010685	catalytic triad [active]
742013010686	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
742013010687	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
742013010688	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
742013010689	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879
742013010690	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
742013010691	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
742013010692	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
742013010693	Walker A/P-loop; other site
742013010694	ATP binding site [chemical binding]; other site
742013010695	Q-loop/lid; other site
742013010696	ABC transporter signature motif; other site
742013010697	Walker B; other site
742013010698	D-loop; other site
742013010699	H-loop/switch region; other site
742013010700	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
742013010701	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
742013010702	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
742013010703	TM-ABC transporter signature motif; other site
742013010704	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
742013010705	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
742013010706	substrate binding site [chemical binding]; other site
742013010707	ATP binding site [chemical binding]; other site
742013010708	Tagatose 6 phosphate kinase; Region: Tagatose_6_P_K; pfam08013
742013010709	Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402
742013010710	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
742013010711	oligomeric interface; other site
742013010712	putative active site [active]
742013010713	homodimer interface [polypeptide binding]; other site
742013010714	Transcriptional regulator [Transcription]; Region: LysR; COG0583
742013010715	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
742013010716	TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440
742013010717	putative dimerization interface [polypeptide binding]; other site
742013010718	Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385
742013010719	SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593
742013010720	Cupin domain; Region: Cupin_2; pfam07883
742013010721	NLPA lipoprotein; Region: Lipoprotein_9; pfam03180
742013010722	ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464
742013010723	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
742013010724	dimer interface [polypeptide binding]; other site
742013010725	conserved gate region; other site
742013010726	ABC-ATPase subunit interface; other site
742013010727	DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153
742013010728	ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258
742013010729	Walker A/P-loop; other site
742013010730	ATP binding site [chemical binding]; other site
742013010731	Q-loop/lid; other site
742013010732	ABC transporter signature motif; other site
742013010733	Walker B; other site
742013010734	D-loop; other site
742013010735	H-loop/switch region; other site
742013010736	NIL domain; Region: NIL; pfam09383
742013010737	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
742013010738	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
742013010739	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
742013010740	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
742013010741	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
742013010742	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159
742013010743	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
742013010744	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
742013010745	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
742013010746	Cytochrome c; Region: Cytochrom_C; pfam00034
742013010747	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
742013010748	Trans-2-enoyl-CoA reductase (TER) and 2,4-dienoyl-CoA reductase (DECR), atypical (a) SDR; Region: TER_DECR_SDR_a; cd05369
742013010749	NAD(P) binding site [chemical binding]; other site
742013010750	substrate binding site [chemical binding]; other site
742013010751	homotetramer interface [polypeptide binding]; other site
742013010752	active site
742013010753	homodimer interface [polypeptide binding]; other site
742013010754	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08276
742013010755	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
742013010756	Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929
742013010757	acyl-activating enzyme (AAE) consensus motif; other site
742013010758	putative AMP binding site [chemical binding]; other site
742013010759	putative active site [active]
742013010760	acyl-activating enzyme (AAE) consensus motif; other site
742013010761	putative CoA binding site [chemical binding]; other site
742013010762	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
742013010763	Transcriptional regulator [Transcription]; Region: LysR; COG0583
742013010764	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
742013010765	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
742013010766	putative effector binding pocket; other site
742013010767	dimerization interface [polypeptide binding]; other site
742013010768	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
742013010769	Uncharacterized enzymes similar to novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like-1; cd12808
742013010770	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
742013010771	catalytic site [active]
742013010772	Transcriptional regulator [Transcription]; Region: LysR; COG0583
742013010773	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
742013010774	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
742013010775	dimerization interface [polypeptide binding]; other site
742013010776	SAM (Sterile alpha motif ); Region: SAM_superfamily; cl15755
742013010777	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
742013010778	non-specific DNA binding site [nucleotide binding]; other site
742013010779	salt bridge; other site
742013010780	sequence-specific DNA binding site [nucleotide binding]; other site
742013010781	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
742013010782	ABC-ATPase subunit  interface; other site
742013010783	dimer interface [polypeptide binding]; other site
742013010784	FecCD transport family; Region: FecCD; pfam01032
742013010785	dimer interface [polypeptide binding]; other site
742013010786	putative PBP binding regions; other site
742013010787	ABC-ATPase subunit  interface; other site
742013010788	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
742013010789	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
742013010790	intersubunit interface [polypeptide binding]; other site
742013010791	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
742013010792	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
742013010793	Walker A/P-loop; other site
742013010794	ATP binding site [chemical binding]; other site
742013010795	Q-loop/lid; other site
742013010796	ABC transporter signature motif; other site
742013010797	Walker B; other site
742013010798	D-loop; other site
742013010799	H-loop/switch region; other site
742013010800	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
742013010801	Transcriptional regulator [Transcription]; Region: IclR; COG1414
742013010802	Bacterial transcriptional regulator; Region: IclR; pfam01614
742013010803	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
742013010804	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
742013010805	N-terminal plug; other site
742013010806	ligand-binding site [chemical binding]; other site
742013010807	nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095
742013010808	active site
742013010809	FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860
742013010810	non-prolyl cis peptide bond; other site
742013010811	DNA-binding transcriptional regulator BaeR; Provisional; Region: PRK10710
742013010812	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
742013010813	active site
742013010814	phosphorylation site [posttranslational modification]
742013010815	intermolecular recognition site; other site
742013010816	dimerization interface [polypeptide binding]; other site
742013010817	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
742013010818	DNA binding site [nucleotide binding]
742013010819	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
742013010820	dimerization interface [polypeptide binding]; other site
742013010821	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
742013010822	dimer interface [polypeptide binding]; other site
742013010823	phosphorylation site [posttranslational modification]
742013010824	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
742013010825	ATP binding site [chemical binding]; other site
742013010826	Mg2+ binding site [ion binding]; other site
742013010827	G-X-G motif; other site
742013010828	Intradiol dioxygenase supgroup. Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. They break the catechol C1-C2 bond and utilize Fe3+, as opposed to  the...; Region: intradiol_dioxygenase_like; cd03457
742013010829	putative active site [active]
742013010830	Malate/L-lactate dehydrogenase; Region: Ldh_2; cl00900
742013010831	Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663
742013010832	Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645
742013010833	trimer interface [polypeptide binding]; other site
742013010834	putative metal binding site [ion binding]; other site
742013010835	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
742013010836	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
742013010837	CoA-transferase family III; Region: CoA_transf_3; pfam02515
742013010838	3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938
742013010839	active site
742013010840	catalytic residues [active]
742013010841	metal binding site [ion binding]; metal-binding site
742013010842	Transcriptional regulator [Transcription]; Region: LysR; COG0583
742013010843	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
742013010844	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_1; cd08421
742013010845	putative dimerization interface [polypeptide binding]; other site
742013010846	Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N; pfam00033
742013010847	Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041
742013010848	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
742013010849	Moco binding site; other site
742013010850	metal coordination site [ion binding]; other site
742013010851	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
742013010852	rRNA binding site [nucleotide binding]; other site
742013010853	predicted 30S ribosome binding site; other site
742013010854	GntP family permease; Region: GntP_permease; pfam02447
742013010855	fructuronate transporter; Provisional; Region: PRK10034; cl15264
742013010856	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
742013010857	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
742013010858	Coenzyme A binding pocket [chemical binding]; other site
742013010859	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
742013010860	active site
742013010861	NTP binding site [chemical binding]; other site
742013010862	metal binding triad [ion binding]; metal-binding site
742013010863	Transcriptional regulators [Transcription]; Region: PurR; COG1609
742013010864	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
742013010865	DNA binding site [nucleotide binding]
742013010866	domain linker motif; other site
742013010867	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
742013010868	2-aminoethylphosphonate ABC transporter, periplasmic 2-aminoethylphosphonate binding protein; Region: PhnS; TIGR03227
742013010869	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
742013010870	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
742013010871	ABC-ATPase subunit interface; other site
742013010872	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
742013010873	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
742013010874	dimer interface [polypeptide binding]; other site
742013010875	conserved gate region; other site
742013010876	putative PBP binding loops; other site
742013010877	ABC-ATPase subunit interface; other site
742013010878	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
742013010879	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
742013010880	Walker A/P-loop; other site
742013010881	ATP binding site [chemical binding]; other site
742013010882	Q-loop/lid; other site
742013010883	ABC transporter signature motif; other site
742013010884	Walker B; other site
742013010885	D-loop; other site
742013010886	H-loop/switch region; other site
742013010887	TOBE domain; Region: TOBE_2; pfam08402
742013010888	Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409
742013010889	Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402
742013010890	active site
742013010891	metal binding site [ion binding]; metal-binding site
742013010892	hexamer interface [polypeptide binding]; other site
742013010893	conserved repeat domain; Region: B_ant_repeat; TIGR01451
742013010894	leucine-responsive transcriptional regulator; Provisional; Region: PRK11169
742013010895	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
742013010896	putative DNA binding site [nucleotide binding]; other site
742013010897	putative Zn2+ binding site [ion binding]; other site
742013010898	AsnC family; Region: AsnC_trans_reg; pfam01037
742013010899	D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711
742013010900	Transcriptional regulator [Transcription]; Region: LysR; COG0583
742013010901	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
742013010902	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
742013010903	dimerization interface [polypeptide binding]; other site
742013010904	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
742013010905	Sulfatase; Region: Sulfatase; pfam00884
742013010906	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
742013010907	Domain of unknown function (DUF4198); Region: DUF4198; pfam10670
742013010908	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
742013010909	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
742013010910	N-terminal plug; other site
742013010911	ligand-binding site [chemical binding]; other site
742013010912	Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain [Transcription]; Region: COG3609
742013010913	nickel responsive regulator; Provisional; Region: PRK02967
742013010914	NikR C terminal nickel binding domain; Region: NikR_C; pfam08753
742013010915	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
742013010916	Major Facilitator Superfamily; Region: MFS_1; pfam07690
742013010917	putative substrate translocation pore; other site
742013010918	Transcriptional regulator [Transcription]; Region: LysR; COG0583
742013010919	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
742013010920	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
742013010921	dimerization interface [polypeptide binding]; other site
742013010922	Protein of unknown function (DUF2938); Region: DUF2938; pfam11158
742013010923	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
742013010924	dimerization interface [polypeptide binding]; other site
742013010925	putative DNA binding site [nucleotide binding]; other site
742013010926	putative Zn2+ binding site [ion binding]; other site
742013010927	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
742013010928	active site residue [active]
742013010929	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
742013010930	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
742013010931	RibD C-terminal domain; Region: RibD_C; cl17279
742013010932	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
742013010933	Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137
742013010934	dimer interface [polypeptide binding]; other site
742013010935	FMN binding site [chemical binding]; other site
742013010936	EamA-like transporter family; Region: EamA; pfam00892
742013010937	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
742013010938	MarR family; Region: MarR_2; cl17246
742013010939	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
742013010940	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
742013010941	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
742013010942	DNA binding residues [nucleotide binding]
742013010943	dimerization interface [polypeptide binding]; other site
742013010944	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
742013010945	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
742013010946	DNA binding residues [nucleotide binding]
742013010947	dimerization interface [polypeptide binding]; other site
742013010948	Secretin and TonB N terminus short domain; Region: STN; smart00965
742013010949	ferrichrome outer membrane transporter; Provisional; Region: PRK10044
742013010950	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
742013010951	N-terminal plug; other site
742013010952	ligand-binding site [chemical binding]; other site
742013010953	Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712
742013010954	FecR protein; Region: FecR; pfam04773
742013010955	RNA polymerase sigma factor; Provisional; Region: PRK12528
742013010956	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
742013010957	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
742013010958	DNA binding residues [nucleotide binding]
742013010959	glutathionine S-transferase; Provisional; Region: PRK10542
742013010960	GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057
742013010961	C-terminal domain interface [polypeptide binding]; other site
742013010962	GSH binding site (G-site) [chemical binding]; other site
742013010963	dimer interface [polypeptide binding]; other site
742013010964	C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188
742013010965	dimer interface [polypeptide binding]; other site
742013010966	N-terminal domain interface [polypeptide binding]; other site
742013010967	substrate binding pocket (H-site) [chemical binding]; other site
742013010968	Predicted transcriptional regulators [Transcription]; Region: COG1733
742013010969	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
742013010970	dimerization interface [polypeptide binding]; other site
742013010971	putative DNA binding site [nucleotide binding]; other site
742013010972	putative Zn2+ binding site [ion binding]; other site
742013010973	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
742013010974	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
742013010975	GyrI-like small molecule binding domain; Region: GyrI-like; pfam06445
742013010976	Orthopoxvirus protein of unknown function (DUF830); Region: DUF830; cl13998
742013010977	Restriction endonuclease; Region: Mrr_cat; pfam04471
742013010978	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
742013010979	active site
742013010980	DNA binding site [nucleotide binding]
742013010981	Int/Topo IB signature motif; other site
742013010982	Domain of unknown function (DUF4276); Region: DUF4276; pfam14103
742013010983	BRO family, N-terminal domain; Region: Bro-N; smart01040
742013010984	Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049
742013010985	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
742013010986	dimerization interface [polypeptide binding]; other site
742013010987	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
742013010988	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
742013010989	dimer interface [polypeptide binding]; other site
742013010990	putative CheW interface [polypeptide binding]; other site
742013010991	Transcriptional regulator [Transcription]; Region: LysR; COG0583
742013010992	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
742013010993	LysR substrate binding domain; Region: LysR_substrate; pfam03466
742013010994	dimerization interface [polypeptide binding]; other site
742013010995	Peptidylarginine deiminase and related enzymes [Amino acid transport and metabolism]; Region: COG2957; cl01113
742013010996	Porphyromonas-type peptidyl-arginine deiminase; Region: PAD_porph; pfam04371
742013010997	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
742013010998	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
742013010999	active site
742013011000	phosphorylation site [posttranslational modification]
742013011001	intermolecular recognition site; other site
742013011002	dimerization interface [polypeptide binding]; other site
742013011003	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
742013011004	DNA binding residues [nucleotide binding]
742013011005	dimerization interface [polypeptide binding]; other site
742013011006	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
742013011007	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
742013011008	phosphorylation site [posttranslational modification]
742013011009	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
742013011010	ATP binding site [chemical binding]; other site
742013011011	Mg2+ binding site [ion binding]; other site
742013011012	G-X-G motif; other site
742013011013	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
742013011014	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
742013011015	active site
742013011016	phosphorylation site [posttranslational modification]
742013011017	intermolecular recognition site; other site
742013011018	dimerization interface [polypeptide binding]; other site
742013011019	Response regulator receiver domain; Region: Response_reg; pfam00072
742013011020	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
742013011021	active site
742013011022	phosphorylation site [posttranslational modification]
742013011023	intermolecular recognition site; other site
742013011024	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
742013011025	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
742013011026	dimer interface [polypeptide binding]; other site
742013011027	phosphorylation site [posttranslational modification]
742013011028	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
742013011029	ATP binding site [chemical binding]; other site
742013011030	Mg2+ binding site [ion binding]; other site
742013011031	G-X-G motif; other site
742013011032	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
742013011033	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
742013011034	active site
742013011035	phosphorylation site [posttranslational modification]
742013011036	intermolecular recognition site; other site
742013011037	dimerization interface [polypeptide binding]; other site
742013011038	CSLREA domain; Region: CSLREA_Nterm; TIGR04214
742013011039	nitrous oxide reductase family maturation protein NosD; Region: NosD_copper_fam; TIGR04247
742013011040	Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182
742013011041	PepSY-associated TM helix; Region: PepSY_TM_3; pfam13706
742013011042	PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703
742013011043	Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069
742013011044	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
742013011045	active site
742013011046	FMN binding site [chemical binding]; other site
742013011047	substrate binding site [chemical binding]; other site
742013011048	3Fe-4S cluster binding site [ion binding]; other site
742013011049	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
742013011050	His-Xaa-Ser system radical SAM maturase HxsC; Region: rSAM_pair_HxsC; TIGR03977
742013011051	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
742013011052	FeS/SAM binding site; other site
742013011053	His-Xaa-Ser system radical SAM maturase HxsB; Region: rSAM_paired_1; TIGR03978
742013011054	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
742013011055	FeS/SAM binding site; other site
742013011056	heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386
742013011057	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
742013011058	dimer interface [polypeptide binding]; other site
742013011059	phosphorylation site [posttranslational modification]
742013011060	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
742013011061	ATP binding site [chemical binding]; other site
742013011062	Mg2+ binding site [ion binding]; other site
742013011063	G-X-G motif; other site
742013011064	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
742013011065	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
742013011066	active site
742013011067	phosphorylation site [posttranslational modification]
742013011068	intermolecular recognition site; other site
742013011069	dimerization interface [polypeptide binding]; other site
742013011070	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
742013011071	DNA binding site [nucleotide binding]
742013011072	methionine sulfoxide reductase B; Provisional; Region: PRK00222
742013011073	SelR domain; Region: SelR; pfam01641
742013011074	Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785
742013011075	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788
742013011076	TlpA-like family, DipZ-like subfamily; composed uncharacterized proteins containing a TlpA-like TRX domain. Some members show domain architectures similar to that of E. coli DipZ protein (also known as DsbD). The only eukaryotic members of the TlpA...; Region: TlpA_like_DipZ_like; cd03012
742013011077	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
742013011078	catalytic residues [active]
742013011079	methionine sulfoxide reductase A; Provisional; Region: PRK13014
742013011080	Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059
742013011081	Chromate transporter; Region: Chromate_transp; pfam02417
742013011082	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
742013011083	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
742013011084	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
742013011085	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
742013011086	Solo B3/4 domain (OB-fold DNA/RNA-binding) of Phe-aaRS-beta [General function prediction only]; Region: COG3382
742013011087	B3/4 domain; Region: B3_4; pfam03483
742013011088	ferrichrome outer membrane transporter; Provisional; Region: PRK10044
742013011089	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
742013011090	N-terminal plug; other site
742013011091	ligand-binding site [chemical binding]; other site
742013011092	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
742013011093	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
742013011094	Transcriptional regulators [Transcription]; Region: GntR; COG1802
742013011095	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
742013011096	DNA-binding site [nucleotide binding]; DNA binding site
742013011097	FCD domain; Region: FCD; pfam07729
742013011098	Domain of unknown function (DUF336); Region: DUF336; cl01249
742013011099	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
742013011100	FAD binding domain; Region: FAD_binding_4; pfam01565
742013011101	4Fe-4S dicluster domain; Region: Fer4_8; pfam13183
742013011102	sn-glycerol-3-phosphate dehydrogenase subunit C; Provisional; Region: glpC; PRK11168
742013011103	Transcriptional regulators [Transcription]; Region: GntR; COG1802
742013011104	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
742013011105	DNA-binding site [nucleotide binding]; DNA binding site
742013011106	FCD domain; Region: FCD; pfam07729
742013011107	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
742013011108	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
742013011109	catalytic residue [active]
742013011110	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181
742013011111	Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331
742013011112	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3333
742013011113	Fic family protein [Function unknown]; Region: COG3177
742013011114	Fic/DOC family; Region: Fic; pfam02661
742013011115	Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598
742013011116	Uncharacterized bacterial subgroup of the Salmonella typhimurium Zn2+ transporter ZntB-like subfamily; Region: ZntB_u1; cd12834
742013011117	Cl binding site [ion binding]; other site
742013011118	oligomer interface [polypeptide binding]; other site
742013011119	Pyrococcus furiosus PF1019 and related proteins, metallophosphatase domain; Region: MPP_PF1019; cd07391
742013011120	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
742013011121	putative active site [active]
742013011122	putative metal binding site [ion binding]; other site
742013011123	DEXH box helicase, DNA ligase-associated; Region: DEXH_lig_assoc; TIGR04121
742013011124	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
742013011125	ATP binding site [chemical binding]; other site
742013011126	putative Mg++ binding site [ion binding]; other site
742013011127	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
742013011128	nucleotide binding region [chemical binding]; other site
742013011129	ATP-binding site [chemical binding]; other site
742013011130	DEAD/H associated; Region: DEAD_assoc; pfam08494
742013011131	ATP-dependent DNA ligase; Validated; Region: PRK09247
742013011132	Adenylation domain of putative bacterial ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_Bac1; cd07897
742013011133	active site
742013011134	DNA binding site [nucleotide binding]
742013011135	The Oligonucleotide/oligosaccharide binding (OB)-fold domain of archaeal and bacterial ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_Arch_LigB; cd07972
742013011136	DNA binding site [nucleotide binding]
742013011137	putative exonuclease, DNA ligase-associated; Region: Xnuc_lig_assoc; TIGR04122
742013011138	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
742013011139	Protein of unknown function (DUF2789); Region: DUF2789; pfam10982
742013011140	Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175
742013011141	Clavaminic acid synthetase (CAS) -like;  CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184
742013011142	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
742013011143	FOG: CBS domain [General function prediction only]; Region: COG0517
742013011144	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
742013011145	Domain of unknown function (DUF1987); Region: DUF1987; pfam09345
742013011146	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
742013011147	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
742013011148	metal binding site [ion binding]; metal-binding site
742013011149	active site
742013011150	I-site; other site
742013011151	Domain of unknown function (DUF3369); Region: DUF3369; pfam11849
742013011152	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
742013011153	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
742013011154	metal binding site [ion binding]; metal-binding site
742013011155	active site
742013011156	I-site; other site
742013011157	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
742013011158	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
742013011159	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
742013011160	DNA-binding site [nucleotide binding]; DNA binding site
742013011161	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
742013011162	pyridoxal 5'-phosphate binding site [chemical binding]; other site
742013011163	homodimer interface [polypeptide binding]; other site
742013011164	catalytic residue [active]
742013011165	Predicted amidohydrolase [General function prediction only]; Region: COG0388
742013011166	Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197
742013011167	active site
742013011168	catalytic triad [active]
742013011169	dimer interface [polypeptide binding]; other site
742013011170	Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982
742013011171	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
742013011172	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
742013011173	catalytic residue [active]
742013011174	Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711
742013011175	biotin carboxylase-like protein; Validated; Region: PRK06524
742013011176	ATP-grasp domain; Region: ATP-grasp_4; pfam13535
742013011177	The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid.  N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467
742013011178	active site
742013011179	Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase; Region: AAT; pfam03417
742013011180	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
742013011181	Sodium:dicarboxylate symporter family; Region: SDF; cl00573
742013011182	glutamate and aspartate transporter subunit; Provisional; Region: PRK10797
742013011183	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
742013011184	substrate binding pocket [chemical binding]; other site
742013011185	membrane-bound complex binding site; other site
742013011186	hinge residues; other site
742013011187	gamma-aminobutyrate permease; Region: GABAperm; TIGR01773
742013011188	aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273
742013011189	Aspartase; Region: Aspartase; cd01357
742013011190	active sites [active]
742013011191	tetramer interface [polypeptide binding]; other site
742013011192	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
742013011193	Major Facilitator Superfamily; Region: MFS_1; pfam07690
742013011194	putative substrate translocation pore; other site
742013011195	Beta-lactamase; Region: Beta-lactamase; pfam00144
742013011196	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
742013011197	Transcriptional regulator [Transcription]; Region: LysR; COG0583
742013011198	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
742013011199	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_7; cd08476
742013011200	putative dimerization interface [polypeptide binding]; other site
742013011201	putative effector binding pocket; other site
742013011202	PAS domain S-box; Region: sensory_box; TIGR00229
742013011203	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
742013011204	heme pocket [chemical binding]; other site
742013011205	putative active site [active]
742013011206	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
742013011207	PAS fold; Region: PAS_3; pfam08447
742013011208	putative active site [active]
742013011209	heme pocket [chemical binding]; other site
742013011210	PAS domain; Region: PAS_9; pfam13426
742013011211	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
742013011212	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
742013011213	metal binding site [ion binding]; metal-binding site
742013011214	active site
742013011215	I-site; other site
742013011216	Family of unknown function (DUF1028); Region: DUF1028; pfam06267
742013011217	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
742013011218	homotrimer interaction site [polypeptide binding]; other site
742013011219	putative active site [active]
742013011220	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
742013011221	flavin-dependent oxidoreductase, MSMEG_0569 family; Region: MSMEG_0569_nitr; TIGR04046
742013011222	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
742013011223	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
742013011224	Walker A/P-loop; other site
742013011225	ATP binding site [chemical binding]; other site
742013011226	Q-loop/lid; other site
742013011227	ABC transporter signature motif; other site
742013011228	Walker B; other site
742013011229	D-loop; other site
742013011230	H-loop/switch region; other site
742013011231	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
742013011232	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
742013011233	Walker A/P-loop; other site
742013011234	ATP binding site [chemical binding]; other site
742013011235	Q-loop/lid; other site
742013011236	ABC transporter signature motif; other site
742013011237	Walker B; other site
742013011238	D-loop; other site
742013011239	H-loop/switch region; other site
742013011240	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
742013011241	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
742013011242	TM-ABC transporter signature motif; other site
742013011243	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
742013011244	TM-ABC transporter signature motif; other site
742013011245	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
742013011246	Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342
742013011247	dimerization interface [polypeptide binding]; other site
742013011248	ligand binding site [chemical binding]; other site
742013011249	4-hydroxyphenylacetate 3-hydroxylase N terminal; Region: HpaB_N; pfam11794
742013011250	4-hydroxyphenylacetate 3-hydroxylase C terminal; Region: HpaB; pfam03241
742013011251	Transcriptional regulator [Transcription]; Region: LysR; COG0583
742013011252	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
742013011253	The C-terminal substrate-binding domain of putative LysR-type transcriptional regulator PAO1-like, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_PAO1_like; cd08412
742013011254	putative substrate binding pocket [chemical binding]; other site
742013011255	dimerization interface [polypeptide binding]; other site
742013011256	RibD C-terminal domain; Region: RibD_C; cl17279
742013011257	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
742013011258	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933
742013011259	FMN binding site [chemical binding]; other site
742013011260	active site
742013011261	substrate binding site [chemical binding]; other site
742013011262	catalytic residue [active]
742013011263	Arginate lyase and other MDR family members; Region: AL_MDR; cd08252
742013011264	zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817
742013011265	putative NAD(P) binding site [chemical binding]; other site
742013011266	dimer interface [polypeptide binding]; other site
742013011267	Uncharacterized conserved protein [Function unknown]; Region: COG1359
742013011268	Transcriptional regulator [Transcription]; Region: LysR; COG0583
742013011269	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
742013011270	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
742013011271	dimerization interface [polypeptide binding]; other site
742013011272	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
742013011273	5-carboxymethyl-2-hydroxymuconate isomerase (CHMI) is a trimeric enzyme catalyzing the isomerization of the unsaturated ketone 5-(carboxymethyl)-2-hydroxymuconate to 5-(carboxymethyl)-2-oxo-3-hexene-1,6-dionate. This is one step in the...; Region: CHMI; cl01268
742013011274	putative substrate binding pocket [chemical binding]; other site
742013011275	trimer interface [polypeptide binding]; other site
742013011276	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
742013011277	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
742013011278	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
742013011279	Demethylmenaquinone methyltransferase [Coenzyme metabolism]; Region: MenG; COG0684
742013011280	Acetoacetate decarboxylase (ADC); Region: ADC; pfam06314
742013011281	beta-ketothiolase; Provisional; Region: PRK09051
742013011282	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
742013011283	dimer interface [polypeptide binding]; other site
742013011284	active site
742013011285	AMP-binding domain protein; Validated; Region: PRK08315
742013011286	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
742013011287	Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917
742013011288	acyl-activating enzyme (AAE) consensus motif; other site
742013011289	putative AMP binding site [chemical binding]; other site
742013011290	putative active site [active]
742013011291	putative CoA binding site [chemical binding]; other site
742013011292	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
742013011293	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
742013011294	substrate binding site [chemical binding]; other site
742013011295	oxyanion hole (OAH) forming residues; other site
742013011296	trimer interface [polypeptide binding]; other site
742013011297	Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159
742013011298	active site
742013011299	Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525
742013011300	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
742013011301	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
742013011302	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
742013011303	substrate binding site [chemical binding]; other site
742013011304	oxyanion hole (OAH) forming residues; other site
742013011305	trimer interface [polypeptide binding]; other site
742013011306	indolepyruvate ferredoxin oxidoreductase; Validated; Region: PRK09193
742013011307	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
742013011308	dimer interface [polypeptide binding]; other site
742013011309	PYR/PP interface [polypeptide binding]; other site
742013011310	TPP binding site [chemical binding]; other site
742013011311	substrate binding site [chemical binding]; other site
742013011312	Thiamine pyrophosphate (TPP) family, IOR-alpha subfamily, TPP-binding module; composed of proteins similar to indolepyruvate ferredoxin oxidoreductase (IOR) alpha subunit. IOR catalyzes the oxidative decarboxylation of arylpyruvates, such as...; Region: TPP_IOR_alpha; cd02008
742013011313	TPP-binding site; other site
742013011314	indolepyruvate oxidoreductase subunit beta; Reviewed; Region: PRK06853
742013011315	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
742013011316	AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_2; cd03138
742013011317	conserved cys residue [active]
742013011318	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
742013011319	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
742013011320	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
742013011321	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
742013011322	ligand binding site [chemical binding]; other site
742013011323	Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545
742013011324	putative switch regulator; other site
742013011325	non-specific DNA interactions [nucleotide binding]; other site
742013011326	DNA binding site [nucleotide binding]
742013011327	sequence specific DNA binding site [nucleotide binding]; other site
742013011328	putative cAMP binding site [chemical binding]; other site
742013011329	2-hydroxychromene-2-carboxylate isomerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NahD; COG3917
742013011330	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
742013011331	GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048
742013011332	C-terminal domain interface [polypeptide binding]; other site
742013011333	GSH binding site (G-site) [chemical binding]; other site
742013011334	dimer interface [polypeptide binding]; other site
742013011335	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776
742013011336	N-terminal domain interface [polypeptide binding]; other site
742013011337	dimer interface [polypeptide binding]; other site
742013011338	substrate binding pocket (H-site) [chemical binding]; other site
742013011339	GMP synthase; Reviewed; Region: guaA; PRK00074
742013011340	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
742013011341	AMP/PPi binding site [chemical binding]; other site
742013011342	candidate oxyanion hole; other site
742013011343	catalytic triad [active]
742013011344	potential glutamine specificity residues [chemical binding]; other site
742013011345	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
742013011346	ATP Binding subdomain [chemical binding]; other site
742013011347	Ligand Binding sites [chemical binding]; other site
742013011348	Dimerization subdomain; other site
742013011349	PIN domain of the Pyrobaculum aerophilum Pae0151 and Pae2754 proteins and homologs; Region: PIN_Pae0151; cd09873
742013011350	putative active site [active]
742013011351	homotetrameric interface [polypeptide binding]; other site
742013011352	Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118
742013011353	DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906
742013011354	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
742013011355	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
742013011356	dimerization interface [polypeptide binding]; other site
742013011357	dihydroxy-acid dehydratase; Provisional; Region: PRK00911
742013011358	inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567
742013011359	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
742013011360	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein.  IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601
742013011361	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
742013011362	active site
742013011363	Domain of unknown function (DUF4124); Region: DUF4124; pfam13511
742013011364	hypothetical protein; Validated; Region: PRK01777
742013011365	Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813
742013011366	putative coenzyme Q binding site [chemical binding]; other site
742013011367	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
742013011368	SmpB-tmRNA interface; other site
742013011369	Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640
742013011370	Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640
742013011371	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
742013011372	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
742013011373	DNA binding residues [nucleotide binding]
742013011374	Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662
742013011375	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
742013011376	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
742013011377	3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617
742013011378	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
742013011379	substrate binding site [chemical binding]; other site
742013011380	oxyanion hole (OAH) forming residues; other site
742013011381	trimer interface [polypeptide binding]; other site
742013011382	2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766
742013011383	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
742013011384	(R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway.  The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441
742013011385	active site
742013011386	catalytic site [active]
742013011387	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
742013011388	CoA-transferase family III; Region: CoA_transf_3; pfam02515
742013011389	DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906
742013011390	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
742013011391	The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414
742013011392	dimerization interface [polypeptide binding]; other site
742013011393	substrate binding pocket [chemical binding]; other site
742013011394	Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217
742013011395	Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891
742013011396	G1 box; other site
742013011397	putative GEF interaction site [polypeptide binding]; other site
742013011398	GTP/Mg2+ binding site [chemical binding]; other site
742013011399	Switch I region; other site
742013011400	G2 box; other site
742013011401	G3 box; other site
742013011402	Switch II region; other site
742013011403	G4 box; other site
742013011404	G5 box; other site
742013011405	BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu.  BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691
742013011406	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a highly...; Region: BipA_TypA_C; cd03710
742013011407	tRNA pseudouridine synthase B; Provisional; Region: truB; PRK01851
742013011408	Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573
742013011409	RNA binding site [nucleotide binding]; other site
742013011410	active site
742013011411	ribosome-binding factor A; Validated; Region: rbfA; PRK00521
742013011412	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
742013011413	Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364
742013011414	translation initiation factor IF-2; Region: IF-2; TIGR00487
742013011415	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
742013011416	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
742013011417	G1 box; other site
742013011418	putative GEF interaction site [polypeptide binding]; other site
742013011419	GTP/Mg2+ binding site [chemical binding]; other site
742013011420	Switch I region; other site
742013011421	G2 box; other site
742013011422	G3 box; other site
742013011423	Switch II region; other site
742013011424	G4 box; other site
742013011425	G5 box; other site
742013011426	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
742013011427	Translation-initiation factor 2; Region: IF-2; pfam11987
742013011428	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
742013011429	transcription elongation factor NusA; Validated; Region: nusA; PRK09202
742013011430	NusA N-terminal domain; Region: NusA_N; pfam08529
742013011431	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
742013011432	RNA binding site [nucleotide binding]; other site
742013011433	homodimer interface [polypeptide binding]; other site
742013011434	NusA-like KH domain; Region: KH_5; pfam13184
742013011435	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
742013011436	G-X-X-G motif; other site
742013011437	transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954
742013011438	ribosome maturation protein RimP; Reviewed; Region: PRK00092
742013011439	Sm and related proteins; Region: Sm_like; cl00259
742013011440	Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734
742013011441	putative oligomer interface [polypeptide binding]; other site
742013011442	putative RNA binding site [nucleotide binding]; other site
742013011443	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
742013011444	catalytic residues [active]
742013011445	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
742013011446	Cytochrome c; Region: Cytochrom_C; pfam00034
742013011447	Cytochrome c; Region: Cytochrom_C; cl11414
742013011448	Cytochrome c; Region: Cytochrom_C; cl11414
742013011449	DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]; Region: DnaJ; COG0484
742013011450	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
742013011451	HSP70 interaction site [polypeptide binding]; other site
742013011452	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
742013011453	substrate binding site [polypeptide binding]; other site
742013011454	dimer interface [polypeptide binding]; other site
742013011455	MerR HTH family regulatory protein; Region: MerR_2; pfam13591
742013011456	Lipocalin-like domain; Region: Lipocalin_2; pfam08212
742013011457	ABC-type uncharacterized transport system, duplicated ATPase component [General function prediction only]; Region: COG4172
742013011458	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
742013011459	Walker A/P-loop; other site
742013011460	ATP binding site [chemical binding]; other site
742013011461	Q-loop/lid; other site
742013011462	ABC transporter signature motif; other site
742013011463	Walker B; other site
742013011464	D-loop; other site
742013011465	H-loop/switch region; other site
742013011466	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
742013011467	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
742013011468	Walker A/P-loop; other site
742013011469	ATP binding site [chemical binding]; other site
742013011470	Q-loop/lid; other site
742013011471	ABC transporter signature motif; other site
742013011472	Walker B; other site
742013011473	D-loop; other site
742013011474	H-loop/switch region; other site
742013011475	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4239
742013011476	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
742013011477	dimer interface [polypeptide binding]; other site
742013011478	conserved gate region; other site
742013011479	putative PBP binding loops; other site
742013011480	ABC-ATPase subunit interface; other site
742013011481	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
742013011482	dimer interface [polypeptide binding]; other site
742013011483	conserved gate region; other site
742013011484	ABC-ATPase subunit interface; other site
742013011485	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
742013011486	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497
742013011487	enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK06997
742013011488	Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372
742013011489	NAD binding site [chemical binding]; other site
742013011490	homotetramer interface [polypeptide binding]; other site
742013011491	homodimer interface [polypeptide binding]; other site
742013011492	substrate binding site [chemical binding]; other site
742013011493	active site
742013011494	Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605
742013011495	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
742013011496	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
742013011497	Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428
742013011498	IclR helix-turn-helix domain; Region: HTH_IclR; cl17605
742013011499	Transcriptional regulator [Transcription]; Region: IclR; COG1414
742013011500	Bacterial transcriptional regulator; Region: IclR; pfam01614
742013011501	3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938
742013011502	active site
742013011503	catalytic residues [active]
742013011504	metal binding site [ion binding]; metal-binding site
742013011505	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
742013011506	CoA-transferase family III; Region: CoA_transf_3; pfam02515
742013011507	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
742013011508	Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709
742013011509	Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982
742013011510	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
742013011511	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
742013011512	catalytic residue [active]
742013011513	Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711
742013011514	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
742013011515	Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403
742013011516	4-Oxalocrotonate Tautomerase:  Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235
742013011517	4-Oxalocrotonate Tautomerase:  Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235
742013011518	active site 1 [active]
742013011519	dimer interface [polypeptide binding]; other site
742013011520	hexamer interface [polypeptide binding]; other site
742013011521	active site 2 [active]
742013011522	Transcriptional regulator [Transcription]; Region: LysR; COG0583
742013011523	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
742013011524	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
742013011525	dimerization interface [polypeptide binding]; other site
742013011526	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
742013011527	(2R,3R)-2,3-butanediol dehydrogenase; Region: butanediol_DH_like; cd08233
742013011528	putative NAD(P) binding site [chemical binding]; other site
742013011529	catalytic Zn binding site [ion binding]; other site
742013011530	SnoaL-like domain; Region: SnoaL_2; pfam12680
742013011531	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
742013011532	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
742013011533	Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284
742013011534	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
742013011535	Walker A motif; other site
742013011536	ATP binding site [chemical binding]; other site
742013011537	Walker B motif; other site
742013011538	arginine finger; other site
742013011539	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
742013011540	PAS domain; Region: PAS; smart00091
742013011541	PAS fold; Region: PAS_4; pfam08448
742013011542	putative active site [active]
742013011543	heme pocket [chemical binding]; other site
742013011544	PAS domain S-box; Region: sensory_box; TIGR00229
742013011545	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
742013011546	putative active site [active]
742013011547	heme pocket [chemical binding]; other site
742013011548	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
742013011549	dimer interface [polypeptide binding]; other site
742013011550	phosphorylation site [posttranslational modification]
742013011551	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
742013011552	ATP binding site [chemical binding]; other site
742013011553	Mg2+ binding site [ion binding]; other site
742013011554	G-X-G motif; other site
742013011555	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
742013011556	active site
742013011557	phosphorylation site [posttranslational modification]
742013011558	intermolecular recognition site; other site
742013011559	dimerization interface [polypeptide binding]; other site
742013011560	Protein of unknown function (DUF2789); Region: DUF2789; pfam10982
742013011561	Secretin and TonB N terminus short domain; Region: STN; smart00965
742013011562	Outer membrane receptor for monomeric catechols [Inorganic ion transport and metabolism]; Region: Fiu; COG4774
742013011563	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
742013011564	N-terminal plug; other site
742013011565	ligand-binding site [chemical binding]; other site
742013011566	Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712
742013011567	FecR protein; Region: FecR; pfam04773
742013011568	RNA polymerase sigma factor; Reviewed; Region: PRK12527
742013011569	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
742013011570	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
742013011571	DNA binding residues [nucleotide binding]
742013011572	Transcriptional regulator [Transcription]; Region: LysR; COG0583
742013011573	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
742013011574	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
742013011575	putative effector binding pocket; other site
742013011576	dimerization interface [polypeptide binding]; other site
742013011577	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
742013011578	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
742013011579	Putative S-adenosyl-L-methionine-dependent methyltransferase; Region: Methyltransf_28; pfam02636
742013011580	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
742013011581	TPR motif; other site
742013011582	binding surface
742013011583	TPR repeat; Region: TPR_11; pfam13414
742013011584	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
742013011585	UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381
742013011586	Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase  family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786
742013011587	active site
742013011588	homodimer interface [polypeptide binding]; other site
742013011589	Bacterial cellulose synthase subunit; Region: BcsB; cl15851
742013011590	bacteriophage N4 adsorption protein B; Provisional; Region: PRK14716
742013011591	active site
742013011592	Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632
742013011593	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
742013011594	TPR motif; other site
742013011595	binding surface
742013011596	Bacteriophage N adsorption protein A C-term; Region: NfrA_C; pfam13283
742013011597	Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696
742013011598	Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236
742013011599	D-alanine:D-alanyl carrier protein ligase (DltA); Region: DltA; cd05945
742013011600	D-alanine--poly(phosphoribitol) ligase subunit 1; Provisional; Region: PRK04813
742013011601	acyl-activating enzyme (AAE) consensus motif; other site
742013011602	AMP binding site [chemical binding]; other site
742013011603	Alginate O-acetyl transferase AlgF; Region: AlgF; pfam11182
742013011604	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
742013011605	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
742013011606	active site
742013011607	hypothetical protein; Provisional; Region: PRK09936
742013011608	C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663
742013011609	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
742013011610	PAS domain; Region: PAS; smart00091
742013011611	PAS fold; Region: PAS_7; pfam12860
742013011612	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
742013011613	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
742013011614	dimer interface [polypeptide binding]; other site
742013011615	phosphorylation site [posttranslational modification]
742013011616	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
742013011617	ATP binding site [chemical binding]; other site
742013011618	Mg2+ binding site [ion binding]; other site
742013011619	G-X-G motif; other site
742013011620	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
742013011621	Response regulator receiver domain; Region: Response_reg; pfam00072
742013011622	active site
742013011623	phosphorylation site [posttranslational modification]
742013011624	intermolecular recognition site; other site
742013011625	dimerization interface [polypeptide binding]; other site
742013011626	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
742013011627	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
742013011628	active site
742013011629	phosphorylation site [posttranslational modification]
742013011630	intermolecular recognition site; other site
742013011631	dimerization interface [polypeptide binding]; other site
742013011632	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
742013011633	DNA binding residues [nucleotide binding]
742013011634	dimerization interface [polypeptide binding]; other site
742013011635	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
742013011636	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
742013011637	trimer interface [polypeptide binding]; other site
742013011638	eyelet of channel; other site
742013011639	ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463
742013011640	mce related protein; Region: MCE; pfam02470
742013011641	Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424
742013011642	Permease; Region: Permease; cl00510
742013011643	zinc-responsive transcriptional regulator; Provisional; Region: zntR; PRK09514
742013011644	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
742013011645	DNA binding residues [nucleotide binding]
742013011646	heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525
742013011647	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
742013011648	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
742013011649	motif II; other site
742013011650	Protein of unknown function (DUF3703); Region: DUF3703; pfam12487
742013011651	Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538
742013011652	Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132
742013011653	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
742013011654	Multicopper oxidase; Region: Cu-oxidase_2; pfam07731
742013011655	Uncharacterized copper-binding protein [Inorganic ion transport and metabolism]; Region: COG4454
742013011656	Predicted metal-binding protein [General function prediction only]; Region: COG3019
742013011657	Copper binding periplasmic protein CusF; Region: CusF_Ec; pfam11604
742013011658	nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252
742013011659	putative active site pocket [active]
742013011660	cleavage site
742013011661	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
742013011662	Protein of unknown function (DUF1631); Region: DUF1631; pfam07793
742013011663	putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819
742013011664	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
742013011665	Walker A/P-loop; other site
742013011666	ATP binding site [chemical binding]; other site
742013011667	Q-loop/lid; other site
742013011668	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
742013011669	ABC transporter; Region: ABC_tran_2; pfam12848
742013011670	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
742013011671	helicase 45; Provisional; Region: PTZ00424
742013011672	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
742013011673	ATP binding site [chemical binding]; other site
742013011674	Mg++ binding site [ion binding]; other site
742013011675	motif III; other site
742013011676	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
742013011677	nucleotide binding region [chemical binding]; other site
742013011678	ATP-binding site [chemical binding]; other site
742013011679	Peptidase M14-like domain; uncharacterized subgroup; Region: M14-like_1_6; cd06243
742013011680	putative active site [active]
742013011681	Zn binding site [ion binding]; other site
742013011682	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
742013011683	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
742013011684	N-terminal plug; other site
742013011685	ligand-binding site [chemical binding]; other site
742013011686	Protein of unknown function (DUF461); Region: DUF461; pfam04314
742013011687	AZL_007920/MXAN_0976 family protein; Region: AZL_007920_fam; TIGR04052
742013011688	di-heme enzyme, MXAN_0977 family; Region: MXAN_0977_Heme2; TIGR04039
742013011689	Protein of unknown function (DUF461); Region: DUF461; pfam04314
742013011690	LysR family transcriptional regulator; Provisional; Region: PRK14997
742013011691	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
742013011692	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_4; cd08473
742013011693	putative effector binding pocket; other site
742013011694	putative dimerization interface [polypeptide binding]; other site
742013011695	Isochorismatase family; Region: Isochorismatase; pfam00857
742013011696	YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012
742013011697	catalytic triad [active]
742013011698	dimer interface [polypeptide binding]; other site
742013011699	conserved cis-peptide bond; other site
742013011700	YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012
742013011701	Isochorismatase family; Region: Isochorismatase; pfam00857
742013011702	catalytic triad [active]
742013011703	dimer interface [polypeptide binding]; other site
742013011704	conserved cis-peptide bond; other site
742013011705	prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532
742013011706	Tfp pilus assembly protein PilE [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilE; COG4968
742013011707	Tfp pilus assembly protein, tip-associated adhesin PilY1 [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilY1; COG3419
742013011708	Neisseria PilC beta-propeller domain; Region: Neisseria_PilC; pfam05567
742013011709	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544
742013011710	type IV pilus modification protein PilV; Region: type_IV_pilV; TIGR02523
742013011711	SurA N-terminal domain; Region: SurA_N_3; cl07813
742013011712	periplasmic folding chaperone; Provisional; Region: PRK10788
742013011713	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
742013011714	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
742013011715	IHF dimer interface [polypeptide binding]; other site
742013011716	IHF - DNA interface [nucleotide binding]; other site
742013011717	CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; Region: pgsA; TIGR00560
742013011718	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
742013011719	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
742013011720	GIY-YIG motif/motif A; other site
742013011721	active site
742013011722	catalytic site [active]
742013011723	putative DNA binding site [nucleotide binding]; other site
742013011724	metal binding site [ion binding]; metal-binding site
742013011725	UvrB/uvrC motif; Region: UVR; pfam02151
742013011726	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
742013011727	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181
742013011728	3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938
742013011729	active site
742013011730	catalytic residues [active]
742013011731	metal binding site [ion binding]; metal-binding site
742013011732	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
742013011733	CoA-transferase family III; Region: CoA_transf_3; pfam02515
742013011734	Transcriptional regulator [Transcription]; Region: LysR; COG0583
742013011735	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
742013011736	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_1; cd08421
742013011737	putative dimerization interface [polypeptide binding]; other site
742013011738	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4394
742013011739	Uncharacterized protein conserved in bacteria (DUF2331); Region: DUF2331; pfam10093
742013011740	elongation factor P; Validated; Region: PRK00529
742013011741	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
742013011742	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
742013011743	RNA binding site [nucleotide binding]; other site
742013011744	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
742013011745	RNA binding site [nucleotide binding]; other site
742013011746	Uncharacterized protein conserved in bacteria (DUF2239); Region: DUF2239; pfam09998
742013011747	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138
742013011748	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
742013011749	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
742013011750	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297
742013011751	NAD binding site [chemical binding]; other site
742013011752	substrate binding site [chemical binding]; other site
742013011753	catalytic Zn binding site [ion binding]; other site
742013011754	tetramer interface [polypeptide binding]; other site
742013011755	structural Zn binding site [ion binding]; other site
742013011756	ribosomal protein S12 methylthiotransferase; Provisional; Region: rimO; PRK14862
742013011757	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
742013011758	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
742013011759	FeS/SAM binding site; other site
742013011760	Protein kinase domain; Region: Pkinase; pfam00069
742013011761	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
742013011762	active site
742013011763	ATP binding site [chemical binding]; other site
742013011764	substrate binding site [chemical binding]; other site
742013011765	activation loop (A-loop); other site
742013011766	Protein of unknown function (DUF2514); Region: DUF2514; pfam10721
742013011767	Peptidase M15; Region: Peptidase_M15_3; cl01194
742013011768	Phage-related minor tail protein [Function unknown]; Region: COG5281
742013011769	PRTRC system ParB family protein; Region: PRTRC_parB; TIGR03734
742013011770	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
742013011771	Domain of unknown function (DUF4145); Region: DUF4145; pfam13643
742013011772	polyhydroxyalkanoate synthesis repressor PhaR; Region: PHA_reg_PhaR; TIGR01848
742013011773	PHB/PHA accumulation regulator DNA-binding domain; Region: PHB_acc_N; pfam07879
742013011774	PHB accumulation regulatory domain; Region: PHB_acc; pfam05233
742013011775	PHB accumulation regulatory domain; Region: PHB_acc; pfam05233
742013011776	allantoate amidohydrolase; Reviewed; Region: PRK12893
742013011777	M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884
742013011778	active site
742013011779	metal binding site [ion binding]; metal-binding site
742013011780	dimer interface [polypeptide binding]; other site
742013011781	phenylhydantoinase; Validated; Region: PRK08323
742013011782	D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine...; Region: D-HYD; cd01314
742013011783	tetramer interface [polypeptide binding]; other site
742013011784	active site
742013011785	uncharacterized nucleobase-cation-symport-1 (NCS1) transporter subfamily, YbbW-like; solute-binding domain; Region: SLC-NCS1sbd_YbbW-like; cd11485
742013011786	Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133
742013011787	Na binding site [ion binding]; other site
742013011788	putative substrate binding site [chemical binding]; other site
742013011789	dihydropyrimidine dehydrogenase subunit B; Validated; Region: PRK08318
742013011790	Dihydropyrimidine dehydrogenase (DHPD) FMN-binding domain.  DHPD catalyzes the first step in pyrimidine degradation: the NADPH-dependent reduction of uracil and thymine to the corresponding 5,6-dihydropyrimidines. DHPD contains two FAD, two FMN, and...; Region: DHPD_FMN; cd02940
742013011791	homodimer interface [polypeptide binding]; other site
742013011792	active site
742013011793	FMN binding site [chemical binding]; other site
742013011794	substrate binding site [chemical binding]; other site
742013011795	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
742013011796	dihydropyrimidine dehydrogenase subunit A; Provisional; Region: PRK11749
742013011797	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
742013011798	pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613
742013011799	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
742013011800	YcdC-like protein, C-terminal region; Region: TetR_C_3; pfam08362
742013011801	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
742013011802	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
742013011803	Coenzyme A binding pocket [chemical binding]; other site
742013011804	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
742013011805	Domain of unknown function (DU1801); Region: DUF1801; cl17490
742013011806	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
742013011807	HD domain; Region: HD_4; pfam13328
742013011808	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
742013011809	synthetase active site [active]
742013011810	NTP binding site [chemical binding]; other site
742013011811	metal binding site [ion binding]; metal-binding site
742013011812	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
742013011813	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
742013011814	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
742013011815	3-hydroxybutyrate dehydrogenase; Provisional; Region: PRK12429
742013011816	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
742013011817	NAD(P) binding site [chemical binding]; other site
742013011818	active site
742013011819	Protein of unknown function (DUF541); Region: SIMPL; cl01077
742013011820	osmolarity response regulator; Provisional; Region: ompR; PRK09468
742013011821	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
742013011822	active site
742013011823	phosphorylation site [posttranslational modification]
742013011824	intermolecular recognition site; other site
742013011825	dimerization interface [polypeptide binding]; other site
742013011826	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
742013011827	DNA binding site [nucleotide binding]
742013011828	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
742013011829	dimerization interface [polypeptide binding]; other site
742013011830	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
742013011831	dimer interface [polypeptide binding]; other site
742013011832	phosphorylation site [posttranslational modification]
742013011833	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
742013011834	ATP binding site [chemical binding]; other site
742013011835	Mg2+ binding site [ion binding]; other site
742013011836	G-X-G motif; other site
742013011837	MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554
742013011838	homotrimer interaction site [polypeptide binding]; other site
742013011839	zinc binding site [ion binding]; other site
742013011840	CDP-binding sites; other site
742013011841	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
742013011842	substrate binding site; other site
742013011843	dimer interface; other site
742013011844	Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197
742013011845	CarD-like/TRCF domain; Region: CarD_TRCF; smart01058
742013011846	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
742013011847	ATP binding site [chemical binding]; other site
742013011848	putative Mg++ binding site [ion binding]; other site
742013011849	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
742013011850	nucleotide binding region [chemical binding]; other site
742013011851	ATP-binding site [chemical binding]; other site
742013011852	This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982
742013011853	Predicted membrane protein [Function unknown]; Region: COG3235
742013011854	Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560
742013011855	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
742013011856	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
742013011857	motif II; other site
742013011858	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
742013011859	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
742013011860	catalytic residues [active]
742013011861	catalytic nucleophile [active]
742013011862	Presynaptic Site I dimer interface [polypeptide binding]; other site
742013011863	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
742013011864	Synaptic Flat tetramer interface [polypeptide binding]; other site
742013011865	Synaptic Site I dimer interface [polypeptide binding]; other site
742013011866	DNA binding site [nucleotide binding]
742013011867	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
742013011868	DNA-binding interface [nucleotide binding]; DNA binding site
742013011869	putative assembly protein; Region: PHA00350
742013011870	Zonular occludens toxin (Zot); Region: Zot; cl17485
742013011871	Protein of unknown function (DUF2523); Region: DUF2523; cl10291
742013011872	DNA directed RNA polymerase, 7 kDa subunit; Region: DNA_RNApol_7kD; cl00874
742013011873	phage/plasmid replication protein, gene II/X family; Region: rep_II_X; TIGR01629
742013011874	Phage replication protein CRI; Region: Phage_CRI; pfam05144
742013011875	Phage X family; Region: Phage_X; cl11585
742013011876	Protein of unknown function (DUF3820); Region: DUF3820; pfam12843
742013011877	NLPA lipoprotein; Region: Lipoprotein_9; pfam03180
742013011878	ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464
742013011879	threonine and homoserine efflux system; Provisional; Region: PRK10532
742013011880	EamA-like transporter family; Region: EamA; pfam00892
742013011881	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
742013011882	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
742013011883	putative DNA binding site [nucleotide binding]; other site
742013011884	putative Zn2+ binding site [ion binding]; other site
742013011885	AsnC family; Region: AsnC_trans_reg; pfam01037
742013011886	Lysine efflux permease [General function prediction only]; Region: COG1279
742013011887	chromosome replication initiation inhibitor protein; Provisional; Region: PRK13348
742013011888	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
742013011889	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
742013011890	dimerization interface [polypeptide binding]; other site
742013011891	Protein of unknown function (DUF2721); Region: DUF2721; pfam11026
742013011892	Transcriptional regulator [Transcription]; Region: LysR; COG0583
742013011893	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
742013011894	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
742013011895	dimerization interface [polypeptide binding]; other site
742013011896	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
742013011897	M20 Peptidase Aminoacylase 1-like protein 2 aminobenzoyl-glutamate utilization protein B subfamily; Region: M20_Acy1L2_AbgB; cd05673
742013011898	amidohydrolase; Region: amidohydrolases; TIGR01891
742013011899	putative metal binding site [ion binding]; other site
742013011900	Protein of unknown function (DUF3149); Region: DUF3149; pfam11346
742013011901	SlyX; Region: SlyX; pfam04102
742013011902	Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436
742013011903	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
742013011904	pyridoxal 5'-phosphate binding site [chemical binding]; other site
742013011905	homodimer interface [polypeptide binding]; other site
742013011906	catalytic residue [active]
742013011907	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
742013011908	amidase; Provisional; Region: PRK07486
742013011909	Amidase; Region: Amidase; cl11426
742013011910	Transcriptional regulator [Transcription]; Region: LysR; COG0583
742013011911	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
742013011912	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
742013011913	dimerization interface [polypeptide binding]; other site
742013011914	Protein of unknown function (DUF1016); Region: DUF1016; pfam06250
742013011915	Predicted nuclease of restriction endonuclease-like fold [General    function prediction only]; Region: COG4804
742013011916	Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177
742013011917	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
742013011918	minor groove reading motif; other site
742013011919	helix-hairpin-helix signature motif; other site
742013011920	substrate binding pocket [chemical binding]; other site
742013011921	active site
742013011922	iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525
742013011923	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181
742013011924	Protein of unknown function (DUF3237); Region: DUF3237; pfam11578
742013011925	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
742013011926	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
742013011927	DNA binding residues [nucleotide binding]
742013011928	dimerization interface [polypeptide binding]; other site
742013011929	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
742013011930	Transcriptional regulator [Transcription]; Region: LysR; COG0583
742013011931	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
742013011932	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_1; cd08421
742013011933	putative dimerization interface [polypeptide binding]; other site
742013011934	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
742013011935	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
742013011936	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
742013011937	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
742013011938	DNA-binding site [nucleotide binding]; DNA binding site
742013011939	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
742013011940	pyridoxal 5'-phosphate binding site [chemical binding]; other site
742013011941	homodimer interface [polypeptide binding]; other site
742013011942	catalytic residue [active]
742013011943	Phosphoribosyltransferase; Region: DBI_PRT; pfam02277
742013011944	Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439
742013011945	putative dimer interface [polypeptide binding]; other site
742013011946	active site pocket [active]
742013011947	putative cataytic base [active]
742013011948	Transcriptional regulators [Transcription]; Region: FadR; COG2186
742013011949	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
742013011950	DNA-binding site [nucleotide binding]; DNA binding site
742013011951	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
742013011952	putative aldolase; Validated; Region: PRK08130
742013011953	intersubunit interface [polypeptide binding]; other site
742013011954	active site
742013011955	Zn2+ binding site [ion binding]; other site
742013011956	4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332
742013011957	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
742013011958	putative substrate translocation pore; other site
742013011959	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
742013011960	Escherichia coli Gne (a nucleoside-diphosphate-sugar 4-epimerase)-like, extended (e) SDRs; Region: Gne_like_SDR_e; cd05238
742013011961	putative NAD(P) binding site [chemical binding]; other site
742013011962	active site
742013011963	putative substrate binding site [chemical binding]; other site
742013011964	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
742013011965	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
742013011966	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395
742013011967	Hydroxypyruvate isomerase [Carbohydrate transport and metabolism]; Region: Hfi; COG3622
742013011968	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
742013011969	cobyric acid synthase; Provisional; Region: PRK00784
742013011970	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
742013011971	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
742013011972	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750
742013011973	catalytic triad [active]
742013011974	Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079
742013011975	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
742013011976	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
742013011977	catalytic residue [active]
742013011978	CobD/Cbib protein; Region: CobD_Cbib; pfam03186
742013011979	Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer,  utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514
742013011980	FMN binding site [chemical binding]; other site
742013011981	dimer interface [polypeptide binding]; other site
742013011982	ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109
742013011983	ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561
742013011984	homodimer interface [polypeptide binding]; other site
742013011985	Walker A motif; other site
742013011986	ATP binding site [chemical binding]; other site
742013011987	hydroxycobalamin binding site [chemical binding]; other site
742013011988	Walker B motif; other site
742013011989	Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; pfam01177
742013011990	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
742013011991	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
742013011992	substrate binding pocket [chemical binding]; other site
742013011993	membrane-bound complex binding site; other site
742013011994	hinge residues; other site
742013011995	hypothetical protein; Provisional; Region: PRK07483
742013011996	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
742013011997	inhibitor-cofactor binding pocket; inhibition site
742013011998	pyridoxal 5'-phosphate binding site [chemical binding]; other site
742013011999	catalytic residue [active]
742013012000	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
742013012001	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
742013012002	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
742013012003	putative active site [active]
742013012004	Aminoglycoside/hydroxyurea antibiotic resistance kinase; Region: APH_6_hur; cl17810
742013012005	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
742013012006	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
742013012007	Walker A/P-loop; other site
742013012008	ATP binding site [chemical binding]; other site
742013012009	Q-loop/lid; other site
742013012010	ABC transporter signature motif; other site
742013012011	Walker B; other site
742013012012	D-loop; other site
742013012013	H-loop/switch region; other site
742013012014	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462
742013012015	FecCD transport family; Region: FecCD; pfam01032
742013012016	putative PBP binding regions; other site
742013012017	ABC-ATPase subunit  interface; other site
742013012018	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
742013012019	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
742013012020	intersubunit interface [polypeptide binding]; other site
742013012021	Cobinamide kinase / cobinamide phosphate guanyltransferase; Region: CobU; cl17363
742013012022	cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077
742013012023	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130
742013012024	catalytic triad [active]
742013012025	Cell division protein ZapA; Region: ZapA; pfam05164
742013012026	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
742013012027	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
742013012028	PAS domain; Region: PAS; smart00091
742013012029	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
742013012030	Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086
742013012031	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
742013012032	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
742013012033	metal binding site [ion binding]; metal-binding site
742013012034	active site
742013012035	I-site; other site
742013012036	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
742013012037	Domain of unknown function (DUF3391); Region: DUF3391; pfam11871
742013012038	HD domain; Region: HD_5; pfam13487
742013012039	Family description; Region: DsbD_2; pfam13386
742013012040	coproporphyrinogen III oxidase; Provisional; Region: PRK09249
742013012041	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
742013012042	FeS/SAM binding site; other site
742013012043	HemN C-terminal domain; Region: HemN_C; pfam06969
742013012044	fumarate/nitrate reduction transcriptional regulator; Provisional; Region: PRK11161
742013012045	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
742013012046	ligand binding site [chemical binding]; other site
742013012047	flexible hinge region; other site
742013012048	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
742013012049	putative switch regulator; other site
742013012050	non-specific DNA interactions [nucleotide binding]; other site
742013012051	DNA binding site [nucleotide binding]
742013012052	sequence specific DNA binding site [nucleotide binding]; other site
742013012053	putative cAMP binding site [chemical binding]; other site
742013012054	cytochrome c oxidase accessory protein FixG; Region: ccoG_rdxA_fixG; TIGR02745
742013012055	4Fe-4S binding domain; Region: Fer4_5; pfam12801
742013012056	Ubp3 associated protein Bre5; Region: Bre5; pfam11614
742013012057	cytochrome c oxidase, cbb3-type, subunit III; Region: ccoP; TIGR00782
742013012058	Cytochrome c; Region: Cytochrom_C; pfam00034
742013012059	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
742013012060	Cbb3-type cytochrome oxidase component FixQ; Region: FixQ; pfam05545
742013012061	Cbb3-type cytochrome oxidase, cytochrome c subunit [Energy production and conversion]; Region: CcoO; COG2993
742013012062	cbb3-type cytochrome c oxidase subunit II; Provisional; Region: PRK14487
742013012063	Cytochrome cbb3 oxidase subunit I.  Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction...; Region: cbb3_Oxidase_I; cd01661
742013012064	Low-spin heme binding site [chemical binding]; other site
742013012065	Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115
742013012066	Putative water exit pathway; other site
742013012067	Binuclear center (active site) [active]
742013012068	Putative proton exit pathway; other site
742013012069	Cytochrome oxidase maturation protein cbb3-type; Region: CcoS; cl01253
742013012070	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
742013012071	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
742013012072	metal-binding site [ion binding]
742013012073	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
742013012074	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
742013012075	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
742013012076	Ligand Binding Site [chemical binding]; other site
742013012077	malonyl-CoA synthase; Validated; Region: PRK07514
742013012078	Malonyl-CoA synthetase (MCS); Region: MCS; cd05941
742013012079	acyl-activating enzyme (AAE) consensus motif; other site
742013012080	active site
742013012081	AMP binding site [chemical binding]; other site
742013012082	CoA binding site [chemical binding]; other site
742013012083	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
742013012084	CoA-transferase family III; Region: CoA_transf_3; pfam02515
742013012085	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
742013012086	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
742013012087	enoyl-CoA hydratase; Provisional; Region: PRK06144
742013012088	substrate binding site [chemical binding]; other site
742013012089	oxyanion hole (OAH) forming residues; other site
742013012090	trimer interface [polypeptide binding]; other site
742013012091	Transcriptional regulators [Transcription]; Region: GntR; COG1802
742013012092	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
742013012093	DNA-binding site [nucleotide binding]; DNA binding site
742013012094	FCD domain; Region: FCD; pfam07729
742013012095	Esterase-like activity of phytase; Region: Phytase-like; pfam13449
742013012096	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
742013012097	Malonyl-CoA decarboxylase (MCD); Region: MCD; pfam05292
742013012098	prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052
742013012099	MarR family; Region: MarR; pfam01047
742013012100	Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418
742013012101	acyl-CoA dehydrogenase; Provisional; Region: PTZ00456
742013012102	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
742013012103	active site
742013012104	Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806
742013012105	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
742013012106	putative substrate translocation pore; other site
742013012107	Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042
742013012108	CoA binding domain; Region: CoA_binding_2; pfam13380
742013012109	Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607
742013012110	ATP-grasp domain; Region: ATP-grasp_5; pfam13549
742013012111	p-hydroxycinnamoyl CoA hydratase/lyase; Validated; Region: PRK09120
742013012112	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
742013012113	substrate binding site [chemical binding]; other site
742013012114	oxyanion hole (OAH) forming residues; other site
742013012115	trimer interface [polypeptide binding]; other site
742013012116	Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193
742013012117	Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907
742013012118	heme binding site [chemical binding]; other site
742013012119	ferroxidase pore; other site
742013012120	ferroxidase diiron center [ion binding]; other site
742013012121	dihydroxy-acid dehydratase; Provisional; Region: PRK12448
742013012122	Cytochrome c; Region: Cytochrom_C; cl11414
742013012123	acetyl-CoA synthetase; Provisional; Region: PRK00174
742013012124	Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966
742013012125	active site
742013012126	CoA binding site [chemical binding]; other site
742013012127	acyl-activating enzyme (AAE) consensus motif; other site
742013012128	AMP binding site [chemical binding]; other site
742013012129	acetate binding site [chemical binding]; other site
742013012130	hypothetical protein; Provisional; Region: PRK05208
742013012131	ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175
742013012132	ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294
742013012133	Walker A/P-loop; other site
742013012134	ATP binding site [chemical binding]; other site
742013012135	Q-loop/lid; other site
742013012136	ABC transporter signature motif; other site
742013012137	Walker B; other site
742013012138	D-loop; other site
742013012139	H-loop/switch region; other site
742013012140	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583
742013012141	glycine betaine transporter membrane protein; Provisional; Region: PRK10952
742013012142	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
742013012143	dimer interface [polypeptide binding]; other site
742013012144	conserved gate region; other site
742013012145	putative PBP binding loops; other site
742013012146	ABC-ATPase subunit interface; other site
742013012147	glycine betaine transporter periplasmic subunit; Provisional; Region: proX; PRK11119
742013012148	Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069
742013012149	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
742013012150	active site
742013012151	P-loop; other site
742013012152	phosphorylation site [posttranslational modification]
742013012153	Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; cl17425
742013012154	Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105
742013012155	1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164
742013012156	putative substrate binding site [chemical binding]; other site
742013012157	putative ATP binding site [chemical binding]; other site
742013012158	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
742013012159	active site
742013012160	phosphorylation site [posttranslational modification]
742013012161	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
742013012162	dimerization domain swap beta strand [polypeptide binding]; other site
742013012163	regulatory protein interface [polypeptide binding]; other site
742013012164	active site
742013012165	regulatory phosphorylation site [posttranslational modification]; other site
742013012166	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
742013012167	Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080
742013012168	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
742013012169	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
742013012170	Transcriptional regulators [Transcription]; Region: PurR; COG1609
742013012171	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
742013012172	DNA binding site [nucleotide binding]
742013012173	domain linker motif; other site
742013012174	Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_4; cd06280
742013012175	putative ligand binding site [chemical binding]; other site
742013012176	putative dimerization interface [polypeptide binding]; other site
742013012177	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
742013012178	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
742013012179	Sulfate transporter family; Region: Sulfate_transp; pfam00916
742013012180	Sulfate transporter family; Region: Sulfate_transp; pfam00916
742013012181	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
742013012182	Putative ParB-like nuclease; Region: ParBc_2; cl17538
742013012183	Protein of unknown function (DUF3334); Region: DUF3334; pfam11813
742013012184	Transcriptional regulators [Transcription]; Region: MarR; COG1846
742013012185	Winged helix DNA-binding domain; Region: HTH_27; pfam13463
742013012186	drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710
742013012187	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
742013012188	putative substrate translocation pore; other site
742013012189	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819
742013012190	Putative esterase; Region: Esterase; pfam00756
742013012191	S-formylglutathione hydrolase; Region: PLN02442
742013012192	fumarate hydratase; Reviewed; Region: fumC; PRK00485
742013012193	Class II fumarases; Region: Fumarase_classII; cd01362
742013012194	active site
742013012195	tetramer interface [polypeptide binding]; other site
742013012196	Fumarate hydratase (Fumerase); Region: Fumerase; pfam05681
742013012197	Fumarase C-terminus; Region: Fumerase_C; pfam05683
742013012198	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
742013012199	S-adenosylmethionine binding site [chemical binding]; other site
742013012200	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
742013012201	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
742013012202	glutamate racemase; Provisional; Region: PRK00865
742013012203	Predicted metal-dependent hydrolase [General function prediction only]; Region: COG1451
742013012204	Transposase, Mutator family; Region: Transposase_mut; pfam00872
742013012205	MULE transposase domain; Region: MULE; pfam10551
742013012206	ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466
742013012207	Found in ATP-dependent protease La (LON); Region: LON; smart00464
742013012208	Found in ATP-dependent protease La (LON); Region: LON; smart00464
742013012209	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
742013012210	Walker A motif; other site
742013012211	ATP binding site [chemical binding]; other site
742013012212	Walker B motif; other site
742013012213	arginine finger; other site
742013012214	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
742013012215	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
742013012216	ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689
742013012217	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078
742013012218	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
742013012219	Walker A motif; other site
742013012220	ATP binding site [chemical binding]; other site
742013012221	Walker B motif; other site
742013012222	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
742013012223	Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740
742013012224	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
742013012225	oligomer interface [polypeptide binding]; other site
742013012226	active site residues [active]
742013012227	trigger factor; Provisional; Region: tig; PRK01490
742013012228	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
742013012229	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
742013012230	phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760
742013012231	Mor transcription activator family; Region: Mor; cl02360
742013012232	NADH dehydrogenase subunit E; Provisional; Region: PRK12373
742013012233	Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which  binds to Adenosine nucleotide; Region: AANH_like; cl00292
742013012234	Ligand Binding Site [chemical binding]; other site
742013012235	Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413
742013012236	Domain of unknown function (DUF1983); Region: DUF1983; pfam09327
742013012237	Protein of unknown function (DUF4043); Region: DUF4043; pfam13252
742013012238	thiamine pyrophosphate protein; Validated; Region: PRK08199
742013012239	lysozyme_like domain.  This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222
742013012240	Phage terminase large subunit; Region: Terminase_3; cl12054
742013012241	Terminase small subunit; Region: Terminase_2; cl01513
742013012242	Protein of unknown function (DUF1376); Region: DUF1376; cl01531
742013012243	Predicted transcriptional regulator [Transcription]; Region: COG2932
742013012244	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
742013012245	Catalytic site [active]
742013012246	Ogr/Delta-like zinc finger; Region: Ogr_Delta; pfam04606
742013012247	HipA N-terminal domain; Region: Couple_hipA; pfam13657
742013012248	Toxin module HipA, protein kinase of phosphatidylinositol 3/4-kinase superfamily [General function prediction only]; Region: HipA; COG3550
742013012249	HipA-like N-terminal domain; Region: HipA_N; pfam07805
742013012250	HipA-like C-terminal domain; Region: HipA_C; pfam07804
742013012251	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
742013012252	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
742013012253	non-specific DNA binding site [nucleotide binding]; other site
742013012254	salt bridge; other site
742013012255	sequence-specific DNA binding site [nucleotide binding]; other site
742013012256	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
742013012257	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
742013012258	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
742013012259	HlyD family secretion protein; Region: HlyD_3; pfam13437
742013012260	Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683
742013012261	active site lid residues [active]
742013012262	substrate binding pocket [chemical binding]; other site
742013012263	catalytic residues [active]
742013012264	substrate-Mg2+ binding site; other site
742013012265	aspartate-rich region 1; other site
742013012266	aspartate-rich region 2; other site
742013012267	Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683
742013012268	catalytic residues [active]
742013012269	substrate binding pocket [chemical binding]; other site
742013012270	substrate-Mg2+ binding site; other site
742013012271	aspartate-rich region 1; other site
742013012272	aspartate-rich region 2; other site
742013012273	squalene-associated FAD-dependent desaturase; Region: HpnE; TIGR03467
742013012274	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
742013012275	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
742013012276	DNA-binding transcriptional regulator CsiR; Provisional; Region: PRK11534
742013012277	DNA-binding site [nucleotide binding]; DNA binding site
742013012278	FCD domain; Region: FCD; pfam07729
742013012279	Carboxymuconolactone decarboxylase family; Region: CMD; cl00460
742013012280	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
742013012281	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
742013012282	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
742013012283	Protein of unknown function (DUF2788); Region: DUF2788; pfam10981
742013012284	Predicted integral membrane protein (DUF2189); Region: DUF2189; pfam09955
742013012285	Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011
742013012286	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
742013012287	motif II; other site
742013012288	ferrochelatase; Reviewed; Region: hemH; PRK00035
742013012289	Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411
742013012290	C-terminal domain interface [polypeptide binding]; other site
742013012291	active site
742013012292	Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419
742013012293	active site
742013012294	N-terminal domain interface [polypeptide binding]; other site
742013012295	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
742013012296	active site residue [active]
742013012297	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
742013012298	active site residue [active]
742013012299	putative inner membrane protein; Provisional; Region: PRK11099
742013012300	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
742013012301	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
742013012302	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
742013012303	active site residue [active]
742013012304	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
742013012305	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
742013012306	3HB-oligomer hydrolase (3HBOH); Region: 3HBOH; pfam10605
742013012307	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
742013012308	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
742013012309	TM-ABC transporter signature motif; other site
742013012310	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
742013012311	TM-ABC transporter signature motif; other site
742013012312	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
742013012313	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
742013012314	Walker A/P-loop; other site
742013012315	ATP binding site [chemical binding]; other site
742013012316	Q-loop/lid; other site
742013012317	ABC transporter signature motif; other site
742013012318	Walker B; other site
742013012319	D-loop; other site
742013012320	H-loop/switch region; other site
742013012321	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
742013012322	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
742013012323	Walker A/P-loop; other site
742013012324	ATP binding site [chemical binding]; other site
742013012325	Q-loop/lid; other site
742013012326	ABC transporter signature motif; other site
742013012327	Walker B; other site
742013012328	D-loop; other site
742013012329	H-loop/switch region; other site
742013012330	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
742013012331	Periplasmic solute-binding domain of active transport proteins found in gram-negative and gram-positive bacteria; Region: PBP1_SBP_like_2; cd06328
742013012332	putative ligand binding site [chemical binding]; other site
742013012333	methionine synthase; Provisional; Region: PRK01207
742013012334	CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311
742013012335	substrate binding site [chemical binding]; other site
742013012336	THF binding site; other site
742013012337	zinc-binding site [ion binding]; other site
742013012338	Domain of unknown function (DUF1852); Region: DUF1852; pfam08908
742013012339	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
742013012340	FMN reductase, MsuE subfamily; Region: FMN_reduc_MsuE; TIGR03566
742013012341	Transcriptional regulator [Transcription]; Region: LysR; COG0583
742013012342	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
742013012343	TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440
742013012344	putative dimerization interface [polypeptide binding]; other site
742013012345	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
742013012346	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
742013012347	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
742013012348	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
742013012349	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
742013012350	trimer interface [polypeptide binding]; other site
742013012351	eyelet of channel; other site
742013012352	AAA domain; Region: AAA_17; pfam13207
742013012353	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
742013012354	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
742013012355	AAA domain; Region: AAA_18; pfam13238
742013012356	Transposase; Region: HTH_Tnp_1; cl17663
742013012357	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
742013012358	IS2 transposase TnpB; Reviewed; Region: PRK09409
742013012359	HTH-like domain; Region: HTH_21; pfam13276
742013012360	Integrase core domain; Region: rve; pfam00665
742013012361	Integrase core domain; Region: rve_3; pfam13683
742013012362	UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580
742013012363	Part of AAA domain; Region: AAA_19; pfam13245
742013012364	Family description; Region: UvrD_C_2; pfam13538
742013012365	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
742013012366	Walker A/P-loop; other site
742013012367	ATP binding site [chemical binding]; other site
742013012368	TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family.  The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026
742013012369	putative active site [active]
742013012370	putative metal-binding site [ion binding]; other site
742013012371	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200
742013012372	Predicted transcriptional regulator [Transcription]; Region: COG2932
742013012373	The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cd06462
742013012374	Catalytic site [active]
742013012375	Domain of unknown function (DUF4272); Region: DUF4272; pfam14094
742013012376	PAS domain; Region: PAS; smart00091
742013012377	PAS fold; Region: PAS_4; pfam08448
742013012378	Uncharacterized protein conserved in archaea (DUF2111); Region: DUF2111; cl01667
742013012379	psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974
742013012380	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
742013012381	Walker A motif; other site
742013012382	ATP binding site [chemical binding]; other site
742013012383	Walker B motif; other site
742013012384	arginine finger; other site
742013012385	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
742013012386	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
742013012387	dimerization interface [polypeptide binding]; other site
742013012388	putative DNA binding site [nucleotide binding]; other site
742013012389	putative Zn2+ binding site [ion binding]; other site
742013012390	Secretin and TonB N terminus short domain; Region: STN; smart00965
742013012391	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
742013012392	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
742013012393	N-terminal plug; other site
742013012394	ligand-binding site [chemical binding]; other site
742013012395	Siderophore binding protein FatB.  These proteins have been shown to function as ABC-type initial receptors in the siderophore-mediated iron uptake in some eubacterial species.  They belong to the TroA superfamily of periplasmic metal binding proteins...; Region: FatB; cd01140
742013012396	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
742013012397	putative ligand binding residues [chemical binding]; other site
742013012398	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
742013012399	ABC-ATPase subunit  interface; other site
742013012400	dimer interface [polypeptide binding]; other site
742013012401	putative PBP binding regions; other site
742013012402	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
742013012403	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
742013012404	ABC-ATPase subunit  interface; other site
742013012405	dimer interface [polypeptide binding]; other site
742013012406	putative PBP binding regions; other site
742013012407	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
742013012408	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
742013012409	Walker A/P-loop; other site
742013012410	ATP binding site [chemical binding]; other site
742013012411	Q-loop/lid; other site
742013012412	ABC transporter signature motif; other site
742013012413	Walker B; other site
742013012414	D-loop; other site
742013012415	H-loop/switch region; other site
742013012416	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
742013012417	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
742013012418	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
742013012419	Walker A/P-loop; other site
742013012420	ATP binding site [chemical binding]; other site
742013012421	Q-loop/lid; other site
742013012422	ABC transporter signature motif; other site
742013012423	Walker B; other site
742013012424	D-loop; other site
742013012425	H-loop/switch region; other site
742013012426	fec operon regulator FecR; Reviewed; Region: PRK09774
742013012427	FecR protein; Region: FecR; pfam04773
742013012428	RNA polymerase sigma factor; Provisional; Region: PRK12528
742013012429	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
742013012430	DNA binding residues [nucleotide binding]
742013012431	SGNH_hydrolase subfamily, similar to the putative arylesterase/acylhydrolase from the rumen anaerobe Prevotella bryantii XynE. The P. bryantii XynE gene is located in a xylanase gene cluster. SGNH hydrolases are a diverse family of lipases and esterases; Region: XynE_like; cd01830
742013012432	active site
742013012433	catalytic triad [active]
742013012434	oxyanion hole [active]
742013012435	hypothetical protein; Provisional; Region: PRK09781; cl08057
742013012436	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
742013012437	RHS Repeat; Region: RHS_repeat; pfam05593
742013012438	RHS Repeat; Region: RHS_repeat; pfam05593
742013012439	RHS Repeat; Region: RHS_repeat; cl11982
742013012440	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
742013012441	RHS protein; Region: RHS; pfam03527
742013012442	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
742013012443	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3333
742013012444	Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331
742013012445	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181
742013012446	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
742013012447	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
742013012448	active site
742013012449	phosphorylation site [posttranslational modification]
742013012450	intermolecular recognition site; other site
742013012451	dimerization interface [polypeptide binding]; other site
742013012452	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
742013012453	DNA binding site [nucleotide binding]
742013012454	Two-component sensor kinase N-terminal; Region: 2CSK_N; pfam08521
742013012455	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
742013012456	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
742013012457	dimer interface [polypeptide binding]; other site
742013012458	phosphorylation site [posttranslational modification]
742013012459	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
742013012460	ATP binding site [chemical binding]; other site
742013012461	Mg2+ binding site [ion binding]; other site
742013012462	G-X-G motif; other site
742013012463	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
742013012464	RNA binding surface [nucleotide binding]; other site
742013012465	xanthine permease; Region: pbuX; TIGR03173
742013012466	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
742013012467	guanine deaminase; Region: guan_deamin; TIGR02967
742013012468	active site
742013012469	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
742013012470	Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553
742013012471	active site
742013012472	uracil binding [chemical binding]; other site
742013012473	aspartate kinase; Reviewed; Region: PRK06635
742013012474	AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261
742013012475	putative nucleotide binding site [chemical binding]; other site
742013012476	putative catalytic residues [active]
742013012477	putative Mg ion binding site [ion binding]; other site
742013012478	putative aspartate binding site [chemical binding]; other site
742013012479	ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913
742013012480	putative allosteric regulatory site; other site
742013012481	ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936
742013012482	putative allosteric regulatory residue; other site
742013012483	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
742013012484	Ligand Binding Site [chemical binding]; other site
742013012485	TilS substrate binding domain; Region: TilS; pfam09179
742013012486	acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724
742013012487	acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198
742013012488	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
742013012489	endonuclease III; Region: ENDO3c; smart00478
742013012490	minor groove reading motif; other site
742013012491	helix-hairpin-helix signature motif; other site
742013012492	substrate binding pocket [chemical binding]; other site
742013012493	active site
742013012494	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
742013012495	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
742013012496	active site
742013012497	HIGH motif; other site
742013012498	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
742013012499	KMSKS motif; other site
742013012500	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
742013012501	tRNA binding surface [nucleotide binding]; other site
742013012502	anticodon binding site; other site
742013012503	TPR repeat; Region: TPR_11; pfam13414
742013012504	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
742013012505	binding surface
742013012506	TPR motif; other site
742013012507	cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920
742013012508	substrate binding site [chemical binding]; other site
742013012509	cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920
742013012510	substrate binding site [chemical binding]; other site
742013012511	Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398
742013012512	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
742013012513	putative active site [active]
742013012514	putative metal binding site [ion binding]; other site
742013012515	Phosphoenolpyruvate:glucose-phosphotransferase regulator; Region: MtfA; pfam06167
742013012516	Transcriptional regulator [Transcription]; Region: LysR; COG0583
742013012517	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
742013012518	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
742013012519	dimerization interface [polypeptide binding]; other site
742013012520	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
742013012521	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
742013012522	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
742013012523	Cytochrome c; Region: Cytochrom_C; pfam00034
742013012524	Cytochrome c [Energy production and conversion]; Region: COG3258
742013012525	Cytochrome c; Region: Cytochrom_C; pfam00034
742013012526	2-oxoacid dehydrogenase subunit E1; Provisional; Region: PRK13012
742013012527	Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017
742013012528	dimer interface [polypeptide binding]; other site
742013012529	TPP-binding site [chemical binding]; other site
742013012530	Transketolase, pyrimidine binding domain; Region: Transket_pyr; smart00861
742013012531	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
742013012532	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
742013012533	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
742013012534	putative DNA binding site [nucleotide binding]; other site
742013012535	putative Zn2+ binding site [ion binding]; other site
742013012536	AsnC family; Region: AsnC_trans_reg; pfam01037
742013012537	Protein of unknown function (DUF3014); Region: DUF3014; pfam11219
742013012538	Predicted esterase [General function prediction only]; Region: COG0400
742013012539	putative hydrolase; Provisional; Region: PRK11460
742013012540	The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363
742013012541	Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900
742013012542	putative active site [active]
742013012543	metal binding site [ion binding]; metal-binding site
742013012544	hypothetical protein; Provisional; Region: PRK09256
742013012545	Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186
742013012546	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
742013012547	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
742013012548	Dehydroquinase class II; Region: DHquinase_II; pfam01220
742013012549	Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466
742013012550	trimer interface [polypeptide binding]; other site
742013012551	active site
742013012552	dimer interface [polypeptide binding]; other site
742013012553	glutaminyl-tRNA synthetase; Provisional; Region: PRK05347
742013012554	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
742013012555	active site
742013012556	HIGH motif; other site
742013012557	nucleotide binding site [chemical binding]; other site
742013012558	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
742013012559	active site
742013012560	KMSKS motif; other site
742013012561	tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950
742013012562	Methyltransferase domain; Region: Methyltransf_12; pfam08242
742013012563	Uncharacterized protein conserved in bacteria (DUF2322); Region: DUF2322; pfam10084
742013012564	Protein of unknown function (DUF3300); Region: DUF3300; pfam11737
742013012565	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
742013012566	Peptidase family M23; Region: Peptidase_M23; pfam01551
742013012567	Uncharacterized protein conserved in bacteria (DUF2242); Region: DUF2242; pfam10001
742013012568	META domain; Region: META; pfam03724
742013012569	Domain of unknown function (DUF4377); Region: DUF4377; pfam14302
742013012570	cardiolipin synthetase; Reviewed; Region: cls; PRK01642
742013012571	Catalytic domain, repeat 1, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_1; cd09152
742013012572	putative active site [active]
742013012573	catalytic site [active]
742013012574	Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_2; cd09158
742013012575	putative active site [active]
742013012576	catalytic site [active]
742013012577	enterobactin exporter EntS; Provisional; Region: PRK10489
742013012578	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
742013012579	diaminopimelate dehydrogenase; Region: DAP-DH; TIGR01921
742013012580	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
742013012581	Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130
742013012582	active site
742013012583	Predicted phosphohydrolase (DHH superfamily) [General function prediction only]; Region: COG2404
742013012584	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
742013012585	M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666
742013012586	metal binding site [ion binding]; metal-binding site
742013012587	putative dimer interface [polypeptide binding]; other site
742013012588	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
742013012589	PAS domain; Region: PAS_9; pfam13426
742013012590	putative active site [active]
742013012591	heme pocket [chemical binding]; other site
742013012592	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
742013012593	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
742013012594	metal binding site [ion binding]; metal-binding site
742013012595	active site
742013012596	I-site; other site
742013012597	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
742013012598	ribosome biogenesis GTP-binding protein YlqF; Region: GTPase_YlqF; TIGR03596
742013012599	Circularly permuted YlqF GTPase; Region: YlqF; cd01856
742013012600	GTP/Mg2+ binding site [chemical binding]; other site
742013012601	G4 box; other site
742013012602	G5 box; other site
742013012603	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
742013012604	G1 box; other site
742013012605	G1 box; other site
742013012606	GTP/Mg2+ binding site [chemical binding]; other site
742013012607	Switch I region; other site
742013012608	G2 box; other site
742013012609	G2 box; other site
742013012610	Switch I region; other site
742013012611	G3 box; other site
742013012612	G3 box; other site
742013012613	Switch II region; other site
742013012614	Switch II region; other site
742013012615	G4 box; other site
742013012616	G5 box; other site
742013012617	Oxidoreductase-like protein, N-terminal; Region: Oxidored-like; pfam09791
742013012618	Glutamate-cysteine ligase; Region: Glu_cys_ligase; cl17352
742013012619	3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826
742013012620	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
742013012621	NAD(P) binding site [chemical binding]; other site
742013012622	active site
742013012623	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
742013012624	catalytic loop [active]
742013012625	iron binding site [ion binding]; other site
742013012626	bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II-like protein; Provisional; Region: PRK14019
742013012627	3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926
742013012628	GTP cyclohydrolase II; Region: GTP_cyclohydro2; pfam00925
742013012629	dimerization interface [polypeptide binding]; other site
742013012630	active site
742013012631	lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209
742013012632	homopentamer interface [polypeptide binding]; other site
742013012633	active site
742013012634	transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202
742013012635	putative RNA binding site [nucleotide binding]; other site
742013012636	aminotransferase; Validated; Region: PRK07337
742013012637	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
742013012638	pyridoxal 5'-phosphate binding site [chemical binding]; other site
742013012639	homodimer interface [polypeptide binding]; other site
742013012640	catalytic residue [active]
742013012641	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
742013012642	active site
742013012643	TolQ protein; Region: tolQ; TIGR02796
742013012644	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
742013012645	TolR protein; Region: tolR; TIGR02801
742013012646	TonB C terminal; Region: TonB_2; pfam13103
742013012647	TolA protein; Region: tolA_full; TIGR02794
742013012648	hypothetical protein; Reviewed; Region: PRK09588
742013012649	Uncharacterized protein family UPF0027; Region: UPF0027; cl17455
742013012650	RF-1 domain; Region: RF-1; cl17422
742013012651	Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186
742013012652	Transcriptional regulator [Transcription]; Region: LysR; COG0583
742013012653	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
742013012654	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
742013012655	dimerization interface [polypeptide binding]; other site
742013012656	putative protease; Provisional; Region: PRK15452
742013012657	Peptidase family U32; Region: Peptidase_U32; pfam01136
742013012658	basic leucine zipper DNA-binding and multimerization region of GCN4 and related proteins; Region: B_zip1; cl02576
742013012659	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
742013012660	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
742013012661	DNA-binding site [nucleotide binding]; DNA binding site
742013012662	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
742013012663	pyridoxal 5'-phosphate binding site [chemical binding]; other site
742013012664	homodimer interface [polypeptide binding]; other site
742013012665	catalytic residue [active]
742013012666	Outer membrane receptor for Fe3+-dicitrate [Inorganic ion transport and metabolism]; Region: FecA; COG4772
742013012667	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
742013012668	N-terminal plug; other site
742013012669	ligand-binding site [chemical binding]; other site
742013012670	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
742013012671	dihydroxy-acid dehydratase; Provisional; Region: PRK00911
742013012672	cytochrome c oxidase accessory protein FixG; Region: ccoG_rdxA_fixG; TIGR02745
742013012673	4Fe-4S binding domain; Region: Fer4_5; pfam12801
742013012674	Ubp3 associated protein Bre5; Region: Bre5; pfam11614
742013012675	Predicted membrane protein (DUF2157); Region: DUF2157; cl10480
742013012676	Domain of unknown function (DUF4401); Region: DUF4401; pfam14351
742013012677	GDYXXLXY protein; Region: GDYXXLXY; pfam14345
742013012678	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
742013012679	CoA-transferase family III; Region: CoA_transf_3; pfam02515
742013012680	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
742013012681	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
742013012682	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
742013012683	active site
742013012684	DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986
742013012685	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
742013012686	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
742013012687	dimerization interface [polypeptide binding]; other site
742013012688	aconitate hydratase; Provisional; Region: acnA; PRK12881
742013012689	Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285
742013012690	substrate binding site [chemical binding]; other site
742013012691	Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285
742013012692	ligand binding site [chemical binding]; other site
742013012693	Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580
742013012694	substrate binding site [chemical binding]; other site
742013012695	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
742013012696	non-specific DNA binding site [nucleotide binding]; other site
742013012697	salt bridge; other site
742013012698	sequence-specific DNA binding site [nucleotide binding]; other site
742013012699	bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238
742013012700	Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576
742013012701	substrate binding site [chemical binding]; other site
742013012702	Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581
742013012703	substrate binding site [chemical binding]; other site
742013012704	ligand binding site [chemical binding]; other site
742013012705	Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301
742013012706	Trans-aconitate methyltransferase [General function prediction only]; Region: Tam; COG4106
742013012707	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
742013012708	S-adenosylmethionine binding site [chemical binding]; other site
742013012709	malate dehydrogenase; Provisional; Region: PRK05442
742013012710	Chloroplast-like malate dehydrogenases; Region: MDH_choloroplast_like; cd01338
742013012711	NAD(P) binding site [chemical binding]; other site
742013012712	dimer interface [polypeptide binding]; other site
742013012713	malate binding site [chemical binding]; other site
742013012714	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
742013012715	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
742013012716	DNA-binding site [nucleotide binding]; DNA binding site
742013012717	The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866
742013012718	Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499
742013012719	Iron-sulfur protein interface; other site
742013012720	proximal quinone binding site [chemical binding]; other site
742013012721	SdhD (CybS) interface [polypeptide binding]; other site
742013012722	proximal heme binding site [chemical binding]; other site
742013012723	Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. E. coli SQR, a member of this subfamily, reduces the...; Region: SQR_TypeC_SdhD; cd03494
742013012724	SdhC subunit interface [polypeptide binding]; other site
742013012725	proximal heme binding site [chemical binding]; other site
742013012726	cardiolipin binding site; other site
742013012727	Iron-sulfur protein interface; other site
742013012728	proximal quinone binding site [chemical binding]; other site
742013012729	succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07057
742013012730	L-aspartate oxidase; Provisional; Region: PRK06175
742013012731	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
742013012732	succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950
742013012733	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085
742013012734	Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114
742013012735	Citrate synthase [Energy production and conversion]; Region: GltA; COG0372
742013012736	dimer interface [polypeptide binding]; other site
742013012737	active site
742013012738	citrylCoA binding site [chemical binding]; other site
742013012739	NADH binding [chemical binding]; other site
742013012740	cationic pore residues; other site
742013012741	oxalacetate/citrate binding site [chemical binding]; other site
742013012742	coenzyme A binding site [chemical binding]; other site
742013012743	catalytic triad [active]
742013012744	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
742013012745	trans-sialidase; Provisional; Region: PTZ00334
742013012746	helicase 45; Provisional; Region: PTZ00424
742013012747	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
742013012748	ATP binding site [chemical binding]; other site
742013012749	Mg++ binding site [ion binding]; other site
742013012750	motif III; other site
742013012751	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
742013012752	nucleotide binding region [chemical binding]; other site
742013012753	ATP-binding site [chemical binding]; other site
742013012754	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
742013012755	AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137
742013012756	conserved cys residue [active]
742013012757	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
742013012758	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
742013012759	class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300
742013012760	S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase; Region: adh_III_F_hyde; TIGR02818
742013012761	substrate binding site [chemical binding]; other site
742013012762	catalytic Zn binding site [ion binding]; other site
742013012763	NAD binding site [chemical binding]; other site
742013012764	structural Zn binding site [ion binding]; other site
742013012765	dimer interface [polypeptide binding]; other site
742013012766	S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821
742013012767	S-formylglutathione hydrolase; Region: PLN02442
742013012768	phosphonoacetaldehyde hydrolase; Provisional; Region: PRK13478
742013012769	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
742013012770	motif II; other site
742013012771	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
742013012772	Hydroxyethylphosphoate dehydrogenase (HEPD) catalyzes the reduction of phosphonoacetaldehyde (PnAA) to hydroxyethylphosphoate (HEP); Region: HEPD; cd08182
742013012773	putative active site [active]
742013012774	metal binding site [ion binding]; metal-binding site
742013012775	phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097
742013012776	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
742013012777	dimer interface [polypeptide binding]; other site
742013012778	conserved gate region; other site
742013012779	putative PBP binding loops; other site
742013012780	ABC-ATPase subunit interface; other site
742013012781	phosphonate ABC transporter, ATP-binding protein; Region: ABC_phnC; TIGR02315
742013012782	ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256
742013012783	Walker A/P-loop; other site
742013012784	ATP binding site [chemical binding]; other site
742013012785	Q-loop/lid; other site
742013012786	ABC transporter signature motif; other site
742013012787	Walker B; other site
742013012788	D-loop; other site
742013012789	H-loop/switch region; other site
742013012790	ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974
742013012791	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
742013012792	substrate binding pocket [chemical binding]; other site
742013012793	membrane-bound complex binding site; other site
742013012794	hinge residues; other site
742013012795	aminoethylphosphonate catabolism associated LysR family transcriptional regulator; Region: phn_lysR; TIGR03339
742013012796	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
742013012797	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
742013012798	dimerization interface [polypeptide binding]; other site
742013012799	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
742013012800	L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948
742013012801	Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316
742013012802	active site pocket [active]
742013012803	Transcriptional regulator [Transcription]; Region: LysR; COG0583
742013012804	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
742013012805	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_2; cd08427
742013012806	putative dimerization interface [polypeptide binding]; other site
742013012807	DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533
742013012808	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
742013012809	FeS/SAM binding site; other site
742013012810	nucleoside diphosphate kinase regulator; Provisional; Region: PRK05753
742013012811	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
742013012812	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
742013012813	Predicted transcriptional regulators [Transcription]; Region: COG1510
742013012814	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
742013012815	putative DNA binding site [nucleotide binding]; other site
742013012816	putative Zn2+ binding site [ion binding]; other site
742013012817	Membrane bound YbgT-like protein; Region: YbgT_YccB; cl02039
742013012818	cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219
742013012819	Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322
742013012820	Cytochrome bd-type quinol oxidase, subunit 1 [Energy production and conversion]; Region: CydA; COG1271
742013012821	cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097
742013012822	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
742013012823	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
742013012824	Walker A/P-loop; other site
742013012825	ATP binding site [chemical binding]; other site
742013012826	Q-loop/lid; other site
742013012827	ABC transporter signature motif; other site
742013012828	Walker B; other site
742013012829	D-loop; other site
742013012830	H-loop/switch region; other site
742013012831	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
742013012832	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
742013012833	ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228
742013012834	Walker A/P-loop; other site
742013012835	ATP binding site [chemical binding]; other site
742013012836	Q-loop/lid; other site
742013012837	ABC transporter signature motif; other site
742013012838	Walker B; other site
742013012839	D-loop; other site
742013012840	H-loop/switch region; other site
742013012841	Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070
742013012842	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
742013012843	FMN binding site [chemical binding]; other site
742013012844	substrate binding site [chemical binding]; other site
742013012845	putative catalytic residue [active]
742013012846	acyl-CoA dehydrogenase; Provisional; Region: PTZ00456
742013012847	Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418
742013012848	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
742013012849	active site
742013012850	Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806
742013012851	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
742013012852	Type I periplasmic binding domain of uncharacterized extracellular ligand-binding proteins; Region: PBP1_STKc_like; cd06326
742013012853	putative ligand binding site [chemical binding]; other site
742013012854	Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025
742013012855	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715
742013012856	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
742013012857	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
742013012858	Ligand binding site [chemical binding]; other site
742013012859	Electron transfer flavoprotein domain; Region: ETF; pfam01012
742013012860	Mechanosensitive ion channel; Region: MS_channel; pfam00924
742013012861	enoyl-CoA hydratase; Validated; Region: PRK08139
742013012862	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
742013012863	substrate binding site [chemical binding]; other site
742013012864	oxyanion hole (OAH) forming residues; other site
742013012865	trimer interface [polypeptide binding]; other site
742013012866	Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123
742013012867	Histone deacetylases and histone-like deacetylases, classII; Region: HDAC_classII_2; cd11599
742013012868	putative active site [active]
742013012869	Zn binding site [ion binding]; other site
742013012870	MoxR-like ATPases [General function prediction only]; Region: COG0714
742013012871	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
742013012872	Walker A motif; other site
742013012873	ATP binding site [chemical binding]; other site
742013012874	Walker B motif; other site
742013012875	arginine finger; other site
742013012876	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
742013012877	Protein of unknown function DUF58; Region: DUF58; pfam01882
742013012878	Domain of unknown function (DUF3488); Region: DUF3488; pfam11992
742013012879	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
742013012880	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
742013012881	Transglycosylase SLT domain; Region: SLT_2; pfam13406
742013012882	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
742013012883	N-acetyl-D-glucosamine binding site [chemical binding]; other site
742013012884	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
742013012885	Periplasmic solute-binding domain of active transport proteins; Region: PBP1_SBP_like_3; cd06329
742013012886	putative ligand binding site [chemical binding]; other site
742013012887	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
742013012888	This domain family includes the alpha-crystallin domain (ACD) of alpha-crystallin-type small heat shock proteins (sHsps) and a similar domain found in p23-like proteins.  sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa; Region: ACD_sHsps_p23-like; cd00298
742013012889	UGMP family protein; Validated; Region: PRK09604
742013012890	Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884
742013012891	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
742013012892	metal binding site [ion binding]; metal-binding site
742013012893	active site
742013012894	I-site; other site
742013012895	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
742013012896	Nitrate and nitrite sensing; Region: NIT; pfam08376
742013012897	ANTAR domain; Region: ANTAR; pfam03861
742013012898	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
742013012899	NMT1-like family; Region: NMT1_2; pfam13379
742013012900	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
742013012901	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
742013012902	dimer interface [polypeptide binding]; other site
742013012903	conserved gate region; other site
742013012904	putative PBP binding loops; other site
742013012905	ABC-ATPase subunit interface; other site
742013012906	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
742013012907	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
742013012908	Walker A/P-loop; other site
742013012909	ATP binding site [chemical binding]; other site
742013012910	Q-loop/lid; other site
742013012911	ABC transporter signature motif; other site
742013012912	Walker B; other site
742013012913	D-loop; other site
742013012914	H-loop/switch region; other site
742013012915	FOG: CBS domain [General function prediction only]; Region: COG0517
742013012916	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623
742013012917	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
742013012918	PAS domain; Region: PAS_9; pfam13426
742013012919	putative active site [active]
742013012920	heme pocket [chemical binding]; other site
742013012921	HAMP domain; Region: HAMP; pfam00672
742013012922	dimerization interface [polypeptide binding]; other site
742013012923	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
742013012924	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
742013012925	dimer interface [polypeptide binding]; other site
742013012926	putative CheW interface [polypeptide binding]; other site
742013012927	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992
742013012928	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
742013012929	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754
742013012930	formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591
742013012931	[4Fe-4S] binding site [ion binding]; other site
742013012932	molybdopterin cofactor binding site; other site
742013012933	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791
742013012934	molybdopterin cofactor binding site; other site
742013012935	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
742013012936	glycosyl transferase family protein; Provisional; Region: PRK08136
742013012937	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
742013012938	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
742013012939	active site
742013012940	SAM binding site [chemical binding]; other site
742013012941	homodimer interface [polypeptide binding]; other site
742013012942	Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062
742013012943	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
742013012944	substrate binding pocket [chemical binding]; other site
742013012945	membrane-bound complex binding site; other site
742013012946	hinge residues; other site
742013012947	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
742013012948	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
742013012949	substrate binding pocket [chemical binding]; other site
742013012950	membrane-bound complex binding site; other site
742013012951	hinge residues; other site
742013012952	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
742013012953	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
742013012954	dimer interface [polypeptide binding]; other site
742013012955	phosphorylation site [posttranslational modification]
742013012956	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
742013012957	ATP binding site [chemical binding]; other site
742013012958	Mg2+ binding site [ion binding]; other site
742013012959	G-X-G motif; other site
742013012960	Response regulator receiver domain; Region: Response_reg; pfam00072
742013012961	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
742013012962	active site
742013012963	phosphorylation site [posttranslational modification]
742013012964	intermolecular recognition site; other site
742013012965	dimerization interface [polypeptide binding]; other site
742013012966	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
742013012967	HI0933-like protein; Region: HI0933_like; pfam03486
742013012968	30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270
742013012969	Yqey-like protein; Region: YqeY; pfam09424
742013012970	transcriptional activator TtdR; Provisional; Region: PRK09801
742013012971	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
742013012972	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_9; cd08479
742013012973	putative effector binding pocket; other site
742013012974	putative dimerization interface [polypeptide binding]; other site
742013012975	Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473
742013012976	tartrate dehydrogenase; Region: TTC; TIGR02089
742013012977	PQQ-like domain; Region: PQQ_2; pfam13360
742013012978	Phosphodiesterase/alkaline phosphatase D [Inorganic ion transport and metabolism]; Region: PhoD; COG3540
742013012979	Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389
742013012980	putative active site [active]
742013012981	putative metal binding site [ion binding]; other site
742013012982	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
742013012983	glutathione reductase; Validated; Region: PRK06116
742013012984	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
742013012985	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
742013012986	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
742013012987	4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332
742013012988	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
742013012989	putative substrate translocation pore; other site
742013012990	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
742013012991	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
742013012992	trimer interface [polypeptide binding]; other site
742013012993	eyelet of channel; other site
742013012994	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
742013012995	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
742013012996	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
742013012997	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
742013012998	iron-sulfur cluster [ion binding]; other site
742013012999	[2Fe-2S] cluster binding site [ion binding]; other site
742013013000	C-terminal catalytic domain of the oxygenase alpha subunit of dicamba O-demethylase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_DMO-like; cd08878
742013013001	alpha subunit interface [polypeptide binding]; other site
742013013002	active site
742013013003	substrate binding site [chemical binding]; other site
742013013004	Fe binding site [ion binding]; other site
742013013005	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
742013013006	phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754
742013013007	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
742013013008	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
742013013009	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
742013013010	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
742013013011	catalytic loop [active]
742013013012	iron binding site [ion binding]; other site
742013013013	pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424
742013013014	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
742013013015	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
742013013016	dimerization interface [polypeptide binding]; other site
742013013017	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181
742013013018	Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613
742013013019	galactarate dehydratase; Region: galactar-dH20; TIGR03248
742013013020	D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295
742013013021	succinic semialdehyde dehydrogenase; Region: PLN02278
742013013022	Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103
742013013023	tetramerization interface [polypeptide binding]; other site
742013013024	NAD(P) binding site [chemical binding]; other site
742013013025	catalytic residues [active]
742013013026	2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase [Carbohydrate transport and metabolism]; Region: HpcH; COG3836
742013013027	Protein of unknown function (DUF3325); Region: DUF3325; pfam11804
742013013028	Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182
742013013029	PepSY-associated TM helix; Region: PepSY_TM_3; pfam13706
742013013030	PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703
742013013031	O-acetylserine/cysteine export protein; Provisional; Region: PRK11453
742013013032	EamA-like transporter family; Region: EamA; pfam00892
742013013033	Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446
742013013034	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
742013013035	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
742013013036	Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384
742013013037	Uncharacterized ACR, COG2135; Region: DUF159; pfam02586
742013013038	Beta-lactamase class D [Defense mechanisms]; Region: COG2602
742013013039	Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004
742013013040	SpoVR family protein; Provisional; Region: PRK11767
742013013041	Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719
742013013042	hypothetical protein; Provisional; Region: PRK05325
742013013043	PrkA family serine protein kinase; Provisional; Region: PRK15455
742013013044	AAA ATPase domain; Region: AAA_16; pfam13191
742013013045	PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798
742013013046	Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794
742013013047	Mechanosensitive ion channel; Region: MS_channel; pfam00924
742013013048	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
742013013049	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
742013013050	dimer interface [polypeptide binding]; other site
742013013051	putative CheW interface [polypeptide binding]; other site
742013013052	peptidase PmbA; Provisional; Region: PRK11040
742013013053	Protein of unknown function (DUF615); Region: DUF615; pfam04751
742013013054	MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886
742013013055	MPT binding site; other site
742013013056	trimer interface [polypeptide binding]; other site
742013013057	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
742013013058	Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327
742013013059	putative ligand binding site [chemical binding]; other site
742013013060	macrolide transporter subunit MacA; Provisional; Region: PRK11578
742013013061	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
742013013062	HlyD family secretion protein; Region: HlyD_3; pfam13437
742013013063	macrolide transporter ATP-binding /permease protein; Provisional; Region: PRK10535
742013013064	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
742013013065	Walker A/P-loop; other site
742013013066	ATP binding site [chemical binding]; other site
742013013067	Q-loop/lid; other site
742013013068	ABC transporter signature motif; other site
742013013069	Walker B; other site
742013013070	D-loop; other site
742013013071	H-loop/switch region; other site
742013013072	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
742013013073	FtsX-like permease family; Region: FtsX; pfam02687
742013013074	Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538
742013013075	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
742013013076	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
742013013077	trimer interface [polypeptide binding]; other site
742013013078	eyelet of channel; other site
742013013079	thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284
742013013080	ThiC-associated domain; Region: ThiC-associated; pfam13667
742013013081	ThiC family; Region: ThiC; pfam01964
742013013082	Nitroreductase family. Members of this family utilize FMN as a cofactor and catalyze reduction of a variety of nitroaromatic compounds, including nitrofurans, nitrobenzens, nitrophenol, nitrobenzoate and quinones by using either NADH or NADPH as a source...; Region: Nitroreductase; cd02136
742013013083	putative FMN binding site [chemical binding]; other site
742013013084	serine O-acetyltransferase; Region: cysE; TIGR01172
742013013085	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
742013013086	trimer interface [polypeptide binding]; other site
742013013087	active site
742013013088	substrate binding site [chemical binding]; other site
742013013089	CoA binding site [chemical binding]; other site
742013013090	rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565
742013013091	SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307
742013013092	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
742013013093	IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639
742013013094	active site
742013013095	dimerization interface [polypeptide binding]; other site
742013013096	elongation factor G; Reviewed; Region: PRK00007
742013013097	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
742013013098	G1 box; other site
742013013099	putative GEF interaction site [polypeptide binding]; other site
742013013100	GTP/Mg2+ binding site [chemical binding]; other site
742013013101	Switch I region; other site
742013013102	G2 box; other site
742013013103	G3 box; other site
742013013104	Switch II region; other site
742013013105	G4 box; other site
742013013106	G5 box; other site
742013013107	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
742013013108	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
742013013109	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
742013013110	helix_turn_helix, Arsenical Resistance Operon Repressor; Region: HTH_ARSR; smart00418
742013013111	putative DNA binding site [nucleotide binding]; other site
742013013112	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313
742013013113	DEAD-like helicases superfamily; Region: DEXDc; smart00487
742013013114	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
742013013115	ATP binding site [chemical binding]; other site
742013013116	putative Mg++ binding site [ion binding]; other site
742013013117	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
742013013118	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
742013013119	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
742013013120	Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286
742013013121	HsdM N-terminal domain; Region: HsdM_N; pfam12161
742013013122	Methyltransferase domain; Region: Methyltransf_26; pfam13659
742013013123	Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000
742013013124	Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116
742013013125	Transcriptional regulator [Transcription]; Region: LysR; COG0583
742013013126	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
742013013127	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472
742013013128	putative effector binding pocket; other site
742013013129	putative dimerization interface [polypeptide binding]; other site
742013013130	short chain dehydrogenase; Provisional; Region: PRK12744
742013013131	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
742013013132	NAD(P) binding site [chemical binding]; other site
742013013133	active site
742013013134	Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230
742013013135	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
742013013136	S-adenosylmethionine binding site [chemical binding]; other site
742013013137	Domain of unknown function (DUF4349); Region: DUF4349; pfam14257
742013013138	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214
742013013139	Protein of unknown function (DUF1006); Region: DUF1006; pfam06224
742013013140	Secretin and TonB N terminus short domain; Region: STN; smart00965
742013013141	Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion transport and metabolism]; Region: FhuE; COG4773
742013013142	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
742013013143	N-terminal plug; other site
742013013144	ligand-binding site [chemical binding]; other site
742013013145	Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712
742013013146	FecR protein; Region: FecR; pfam04773
742013013147	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
742013013148	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
742013013149	DNA binding residues [nucleotide binding]
742013013150	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181
742013013151	acetoacetyl-CoA reductase; Provisional; Region: PRK12824
742013013152	classical (c) SDRs; Region: SDR_c; cd05233
742013013153	NAD(P) binding site [chemical binding]; other site
742013013154	active site
742013013155	acetolactate synthase catalytic subunit; Validated; Region: PRK06112
742013013156	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
742013013157	PYR/PP interface [polypeptide binding]; other site
742013013158	dimer interface [polypeptide binding]; other site
742013013159	TPP binding site [chemical binding]; other site
742013013160	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
742013013161	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568
742013013162	TPP-binding site [chemical binding]; other site
742013013163	SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450
742013013164	Transcriptional regulators [Transcription]; Region: GntR; COG1802
742013013165	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
742013013166	DNA-binding site [nucleotide binding]; DNA binding site
742013013167	FCD domain; Region: FCD; pfam07729
742013013168	portal vertex protein; Provisional; Region: Q; PHA02536
742013013169	Phage portal protein; Region: Phage_portal; pfam04860
742013013170	terminase ATPase subunit; Provisional; Region: P; PHA02535
742013013171	Putative ATPase subunit of terminase (gpP-like); Region: Terminase_5; pfam06056
742013013172	Phage capsid scaffolding protein (GPO) serine peptidase; Region: Phage_GPO; cl15838
742013013173	capsid protein; Provisional; Region: N; PHA02538
742013013174	terminase endonuclease subunit; Provisional; Region: M; PHA02537
742013013175	Phage small terminase subunit; Region: Phage_term_smal; pfam05944
742013013176	Phage head completion protein (GPL); Region: Phage_GPL; pfam05926
742013013177	Phage Tail Protein X; Region: Phage_tail_X; cl02088
742013013178	lysozyme_like domain.  This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222
742013013179	catalytic residue [active]
742013013180	Protein of unknown function (DUF2514); Region: DUF2514; pfam10721
742013013181	P2 phage tail completion protein R (GpR); Region: P2_Phage_GpR; pfam06891
742013013182	Phage virion morphogenesis family; Region: Phage_tail_S; cl02089
742013013183	phage baseplate assembly protein V; Region: phage_P2_V; TIGR01644
742013013184	Phage-related baseplate assembly protein; Region: Phage_base_V; cl17812
742013013185	Gene 25-like lysozyme; Region: GPW_gp25; cl01403
742013013186	Baseplate J-like protein; Region: Baseplate_J; cl01294
742013013187	potential frameshift: common BLAST hit: gi|160898073|ref|YP_001563655.1| virulence-associated protein
742013013188	major tail sheath protein; Provisional; Region: FI; PHA02560
742013013189	Phage tail tube protein FII; Region: Phage_tube; pfam04985
742013013190	Mu-like prophage FluMu protein gp41; Region: FluMu_gp41; pfam10109
742013013191	Phage P2 GpE; Region: Phage_P2_GpE; pfam06528
742013013192	Phage P2 GpU; Region: Phage_P2_GpU; pfam06995
742013013193	Phage late control gene D protein (GPD); Region: Phage_GPD; cl15796
742013013194	Beta protein; Region: Beta_protein; pfam14350
742013013195	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
742013013196	SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974
742013013197	non-specific DNA binding site [nucleotide binding]; other site
742013013198	salt bridge; other site
742013013199	sequence-specific DNA binding site [nucleotide binding]; other site
742013013200	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
742013013201	Catalytic site [active]
742013013202	Ogr/Delta-like zinc finger; Region: Ogr_Delta; pfam04606
742013013203	Bacteriophage replication gene A protein (GPA); Region: Phage_GPA; cl15276
742013013204	Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; cl17523
742013013205	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
742013013206	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
742013013207	active site
742013013208	DNA binding site [nucleotide binding]
742013013209	Int/Topo IB signature motif; other site
742013013210	DNA mismatch repair protein MutS; Provisional; Region: PRK05399
742013013211	MutS domain I; Region: MutS_I; pfam01624
742013013212	MutS domain II; Region: MutS_II; pfam05188
742013013213	MutS domain III; Region: MutS_III; pfam05192
742013013214	MutS domain V; Region: MutS_V; pfam00488
742013013215	Walker A/P-loop; other site
742013013216	ATP binding site [chemical binding]; other site
742013013217	Q-loop/lid; other site
742013013218	ABC transporter signature motif; other site
742013013219	Walker B; other site
742013013220	D-loop; other site
742013013221	H-loop/switch region; other site
742013013222	Predicted proteasome-type protease [Posttranslational modification, protein turnover, chaperones]; Region: COG3484
742013013223	Bacterial proteasome, beta subunit. The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that...; Region: proteasome_beta_bacterial; cd03765
742013013224	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
742013013225	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
742013013226	undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281
742013013227	psiF repeat; Region: PsiF_repeat; pfam07769
742013013228	psiF repeat; Region: PsiF_repeat; pfam07769
742013013229	Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182
742013013230	PepSY-associated TM helix; Region: PepSY_TM_3; pfam13706
742013013231	PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703
742013013232	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
742013013233	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
742013013234	N-terminal plug; other site
742013013235	ligand-binding site [chemical binding]; other site
742013013236	Predicted membrane protein (DUF2306); Region: DUF2306; pfam10067
742013013237	2TM domain; Region: 2TM; pfam13239
742013013238	Histidine kinase; Region: His_kinase; pfam06580
742013013239	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
742013013240	Mg2+ binding site [ion binding]; other site
742013013241	G-X-G motif; other site
742013013242	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
742013013243	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
742013013244	active site
742013013245	phosphorylation site [posttranslational modification]
742013013246	intermolecular recognition site; other site
742013013247	dimerization interface [polypeptide binding]; other site
742013013248	LytTr DNA-binding domain; Region: LytTR; smart00850
742013013249	cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13543
742013013250	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
742013013251	Walker A/P-loop; other site
742013013252	ATP binding site [chemical binding]; other site
742013013253	Q-loop/lid; other site
742013013254	ABC transporter signature motif; other site
742013013255	Walker B; other site
742013013256	D-loop; other site
742013013257	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
742013013258	multidrug efflux system subunit MdtC; Provisional; Region: PRK10614
742013013259	Protein export membrane protein; Region: SecD_SecF; cl14618
742013013260	multidrug efflux system subunit MdtB; Provisional; Region: PRK10503
742013013261	Protein export membrane protein; Region: SecD_SecF; cl14618
742013013262	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
742013013263	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
742013013264	HlyD family secretion protein; Region: HlyD_3; pfam13437
742013013265	Putative lumazine-binding; Region: Lumazine_bd_2; pfam12893
742013013266	AzlC protein; Region: AzlC; pfam03591
742013013267	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
742013013268	salt bridge; other site
742013013269	non-specific DNA binding site [nucleotide binding]; other site
742013013270	sequence-specific DNA binding site [nucleotide binding]; other site
742013013271	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
742013013272	S-adenosylmethionine binding site [chemical binding]; other site
742013013273	Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975
742013013274	XdhC and CoxI family; Region: XdhC_CoxI; pfam02625
742013013275	XdhC Rossmann domain; Region: XdhC_C; pfam13478
742013013276	Carbon monoxide dehydrogenase subunit G (CoxG); Region: CoxG; cd05018
742013013277	putative hydrophobic ligand binding site [chemical binding]; other site
742013013278	Protein containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: CoxE; COG3552
742013013279	MoxR-like ATPases [General function prediction only]; Region: COG0714
742013013280	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319
742013013281	CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092
742013013282	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
742013013283	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
742013013284	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
742013013285	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
742013013286	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
742013013287	catalytic loop [active]
742013013288	iron binding site [ion binding]; other site
742013013289	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
742013013290	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
742013013291	Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; cl01181
742013013292	TRAP-type mannitol/chloroaromatic compound transport system, large permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT3; COG4664
742013013293	DctM-like transporters; Region: DctM; pfam06808
742013013294	TRAP-type mannitol/chloroaromatic compound transport system, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT1; COG4663
742013013295	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441
742013013296	TRAP-type mannitol/chloroaromatic compound transport system, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT1; COG4663
742013013297	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441
742013013298	1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444
742013013299	Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007
742013013300	TPP-binding site; other site
742013013301	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
742013013302	PYR/PP interface [polypeptide binding]; other site
742013013303	dimer interface [polypeptide binding]; other site
742013013304	TPP binding site [chemical binding]; other site
742013013305	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
742013013306	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
742013013307	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
742013013308	substrate binding pocket [chemical binding]; other site
742013013309	chain length determination region; other site
742013013310	substrate-Mg2+ binding site; other site
742013013311	catalytic residues [active]
742013013312	aspartate-rich region 1; other site
742013013313	active site lid residues [active]
742013013314	aspartate-rich region 2; other site
742013013315	exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977
742013013316	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
742013013317	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
742013013318	[2Fe-2S] cluster binding site [ion binding]; other site
742013013319	C-terminal catalytic domain of the oxygenase alpha subunit of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C; cd00680
742013013320	alpha subunit interface [polypeptide binding]; other site
742013013321	active site
742013013322	substrate binding site [chemical binding]; other site
742013013323	Fe binding site [ion binding]; other site
742013013324	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
742013013325	Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897
742013013326	Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448
742013013327	active site residue [active]
742013013328	Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449
742013013329	active site residue [active]
742013013330	Flagellar transcriptional activator (FlhD); Region: FlhD; pfam05247
742013013331	transcriptional activator FlhC; Provisional; Region: PRK12722
742013013332	Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455
742013013333	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
742013013334	phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009
742013013335	Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352
742013013336	porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072
742013013337	Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494
742013013338	domain interfaces; other site
742013013339	active site
742013013340	uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928
742013013341	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
742013013342	active site
742013013343	bifunctional uroporphyrinogen-III synthetase/uroporphyrin-III C-methyltransferase; Reviewed; Region: PRK06975
742013013344	heme biosynthesis-associated TPR protein; Region: TPR_hemY_coli; TIGR00540
742013013345	Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038
742013013346	YceI-like domain; Region: YceI; smart00867
742013013347	Uncharacterized conserved protein [Function unknown]; Region: COG2353
742013013348	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
742013013349	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
742013013350	DNA-binding site [nucleotide binding]; DNA binding site
742013013351	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
742013013352	pyridoxal 5'-phosphate binding site [chemical binding]; other site
742013013353	homodimer interface [polypeptide binding]; other site
742013013354	catalytic residue [active]
742013013355	Putative FMN-binding domain; Region: FMN_bind_2; pfam04299
742013013356	Protein of unknown function (DUF2809); Region: DUF2809; pfam10990
742013013357	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3813
742013013358	Protein of unknown function (DUF1272); Region: DUF1272; pfam06906
742013013359	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
742013013360	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
742013013361	N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346
742013013362	Zn binding site [ion binding]; other site
742013013363	valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729
742013013364	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
742013013365	active site
742013013366	HIGH motif; other site
742013013367	nucleotide binding site [chemical binding]; other site
742013013368	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
742013013369	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
742013013370	active site
742013013371	KMSKS motif; other site
742013013372	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
742013013373	tRNA binding surface [nucleotide binding]; other site
742013013374	anticodon binding site; other site
742013013375	Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458
742013013376	Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
742013013377	dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209
742013013378	active site
742013013379	tetramer interface; other site
742013013380	SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain.  SirA (also known as UvrY,  and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291
742013013381	CPxP  motif; other site
742013013382	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
742013013383	nudix motif; other site
742013013384	cysteine synthase B; Region: cysM; TIGR01138
742013013385	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
742013013386	dimer interface [polypeptide binding]; other site
742013013387	pyridoxal 5'-phosphate binding site [chemical binding]; other site
742013013388	catalytic residue [active]
742013013389	LrgA family; Region: LrgA; pfam03788
742013013390	Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346
742013013391	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
742013013392	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
742013013393	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
742013013394	dimerization interface [polypeptide binding]; other site
742013013395	Glutaryl-CoA dehydrogenase; Region: GCD; cd01151
742013013396	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
742013013397	FAD binding site [chemical binding]; other site
742013013398	substrate binding pocket [chemical binding]; other site
742013013399	catalytic base [active]
742013013400	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
742013013401	CoA-transferase family III; Region: CoA_transf_3; pfam02515
742013013402	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
742013013403	Transcriptional regulator [Transcription]; Region: LysR; COG0583
742013013404	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
742013013405	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
742013013406	dimerization interface [polypeptide binding]; other site
742013013407	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
742013013408	nucleoside/Zn binding site; other site
742013013409	dimer interface [polypeptide binding]; other site
742013013410	catalytic motif [active]
742013013411	putative cyanate transporter; Provisional; Region: cynX; PRK09705
742013013412	putative arabinose transporter; Provisional; Region: PRK03545
742013013413	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
742013013414	putative substrate translocation pore; other site
742013013415	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262
742013013416	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
742013013417	biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244
742013013418	NADH(P)-binding; Region: NAD_binding_10; pfam13460
742013013419	NAD binding site [chemical binding]; other site
742013013420	substrate binding site [chemical binding]; other site
742013013421	putative active site [active]
742013013422	Transcriptional regulator [Transcription]; Region: LysR; COG0583
742013013423	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
742013013424	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
742013013425	putative effector binding pocket; other site
742013013426	dimerization interface [polypeptide binding]; other site
742013013427	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
742013013428	Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342
742013013429	dimerization interface [polypeptide binding]; other site
742013013430	ligand binding site [chemical binding]; other site
742013013431	lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-II; Region: Lumazine_synthase-II; cd09208
742013013432	active site
742013013433	homopentamer interface [polypeptide binding]; other site
742013013434	dimer interface [polypeptide binding]; other site
742013013435	Domain of unknown function (DUF4124); Region: DUF4124; pfam13511
742013013436	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
742013013437	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
742013013438	NAD(P) binding site [chemical binding]; other site
742013013439	active site
742013013440	CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated; Region: PRK07609
742013013441	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
742013013442	catalytic loop [active]
742013013443	iron binding site [ion binding]; other site
742013013444	NAD(P)H dependent flavin oxidoreductases use flavin as a substrate in mediating electron transfer from iron complexes or iron proteins. Structurally similar to ferredoxin reductases, but with only 15% sequence identity, flavin reductases reduce FAD, FMN; Region: flavin_oxioreductase; cd06189
742013013445	FAD binding pocket [chemical binding]; other site
742013013446	FAD binding motif [chemical binding]; other site
742013013447	phosphate binding motif [ion binding]; other site
742013013448	beta-alpha-beta structure motif; other site
742013013449	NAD binding pocket [chemical binding]; other site
742013013450	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
742013013451	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
742013013452	catalytic center binding site [active]
742013013453	ATP binding site [chemical binding]; other site
742013013454	poly(A) polymerase; Region: pcnB; TIGR01942
742013013455	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
742013013456	active site
742013013457	NTP binding site [chemical binding]; other site
742013013458	metal binding triad [ion binding]; metal-binding site
742013013459	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
742013013460	Polymerase A arginine-rich C-terminus; Region: PolyA_pol_arg_C; pfam12626
742013013461	Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560
742013013462	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
742013013463	ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593
742013013464	DnaA regulatory inactivator Hda; Region: DnaA_homol_Hda; TIGR03420
742013013465	Walker A motif; other site
742013013466	ATP binding site [chemical binding]; other site
742013013467	phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385
742013013468	PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196
742013013469	dimerization interface [polypeptide binding]; other site
742013013470	putative ATP binding site [chemical binding]; other site
742013013471	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465
742013013472	Uncharacterized conserved protein [Function unknown]; Region: COG2912
742013013473	Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369
742013013474	MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123
742013013475	MviN-like protein; Region: MVIN; pfam03023
742013013476	30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239
742013013477	Protein of unknown function (DUF3579); Region: DUF3579; pfam12112
742013013478	acetylornithine aminotransferase; Provisional; Region: PRK02627
742013013479	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
742013013480	inhibitor-cofactor binding pocket; inhibition site
742013013481	pyridoxal 5'-phosphate binding site [chemical binding]; other site
742013013482	catalytic residue [active]
742013013483	ornithine carbamoyltransferase; Provisional; Region: PRK00779
742013013484	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
742013013485	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
742013013486	Virus attachment protein p12 family; Region: P12; pfam12669
742013013487	Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370
742013013488	Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879
742013013489	G1 box; other site
742013013490	GTP/Mg2+ binding site [chemical binding]; other site
742013013491	Switch I region; other site
742013013492	G2 box; other site
742013013493	G3 box; other site
742013013494	Switch II region; other site
742013013495	G4 box; other site
742013013496	G5 box; other site
742013013497	Nucleoside recognition; Region: Gate; pfam07670
742013013498	Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664
742013013499	Nucleoside recognition; Region: Gate; pfam07670
742013013500	Fe2+ transport system protein A [Inorganic ion transport and metabolism]; Region: FeoA; COG1918
742013013501	Flagellin N-methylase; Region: FliB; cl00497
742013013502	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
742013013503	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
742013013504	putative DNA binding site [nucleotide binding]; other site
742013013505	putative Zn2+ binding site [ion binding]; other site
742013013506	AsnC family; Region: AsnC_trans_reg; pfam01037
742013013507	Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113
742013013508	aromatic amino acid aminotransferase; Provisional; Region: PRK09257
742013013509	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
742013013510	pyridoxal 5'-phosphate binding site [chemical binding]; other site
742013013511	homodimer interface [polypeptide binding]; other site
742013013512	catalytic residue [active]
742013013513	tryptophan 2,3-dioxygenase; Region: trp_2_3_diox; TIGR03036
742013013514	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
742013013515	homotrimer interaction site [polypeptide binding]; other site
742013013516	putative active site [active]
742013013517	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
742013013518	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
742013013519	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
742013013520	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
742013013521	Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113
742013013522	Putative cyclase; Region: Cyclase; cl00814
742013013523	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
742013013524	kynureninase; Region: kynureninase; TIGR01814
742013013525	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
742013013526	catalytic residue [active]
742013013527	3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122
742013013528	AlkA N-terminal domain; Region: AlkA_N; cl05528
742013013529	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
742013013530	minor groove reading motif; other site
742013013531	helix-hairpin-helix signature motif; other site
742013013532	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
742013013533	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
742013013534	6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870
742013013535	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
742013013536	DNA binding site [nucleotide binding]
742013013537	active site
742013013538	tryptophan 2,3-dioxygenase; Region: trp_2_3_diox; TIGR03036
742013013539	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
742013013540	putative substrate translocation pore; other site
742013013541	Major Facilitator Superfamily; Region: MFS_1; pfam07690
742013013542	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
742013013543	H-NS histone family; Region: Histone_HNS; pfam00816
742013013544	Domain in histone-like proteins of HNS family; Region: HNS; smart00528
742013013545	Domain of unknown function DUF21; Region: DUF21; pfam01595
742013013546	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
742013013547	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
742013013548	Transporter associated domain; Region: CorC_HlyC; smart01091
742013013549	diadenosine tetraphosphatase; Reviewed; Region: apaH; PRK00166
742013013550	Escherichia coli ApaH and related proteins, metallophosphatase domain; Region: MPP_ApaH; cd07422
742013013551	active site
742013013552	metal binding site [ion binding]; metal-binding site
742013013553	helicase 45; Provisional; Region: PTZ00424
742013013554	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
742013013555	ATP binding site [chemical binding]; other site
742013013556	Mg++ binding site [ion binding]; other site
742013013557	motif III; other site
742013013558	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
742013013559	nucleotide binding region [chemical binding]; other site
742013013560	ATP-binding site [chemical binding]; other site
742013013561	Predicted metalloprotease [General function prediction only]; Region: COG2321
742013013562	Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228
742013013563	ornithine cyclodeaminase; Validated; Region: PRK07340
742013013564	ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400
742013013565	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
742013013566	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
742013013567	metal binding site [ion binding]; metal-binding site
742013013568	active site
742013013569	I-site; other site
742013013570	quinolinate synthetase; Provisional; Region: PRK09375
742013013571	L-aspartate oxidase; Provisional; Region: PRK09077
742013013572	L-aspartate oxidase; Provisional; Region: PRK06175
742013013573	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
742013013574	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
742013013575	trimer interface [polypeptide binding]; other site
742013013576	active site
742013013577	guanine deaminase; Provisional; Region: PRK09228
742013013578	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
742013013579	active site
742013013580	Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744
742013013581	Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353
742013013582	putative ligand binding site [chemical binding]; other site
742013013583	HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277
742013013584	HIT family signature motif; other site
742013013585	catalytic residue [active]
742013013586	Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816
742013013587	Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320
742013013588	active site
742013013589	purine riboside binding site [chemical binding]; other site
742013013590	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
742013013591	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
742013013592	[2Fe-2S] cluster binding site [ion binding]; other site
742013013593	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
742013013594	hydrophobic ligand binding site; other site
742013013595	Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744
742013013596	Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353
742013013597	putative ligand binding site [chemical binding]; other site
742013013598	Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744
742013013599	Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353
742013013600	putative ligand binding site [chemical binding]; other site
742013013601	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
742013013602	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
742013013603	TM-ABC transporter signature motif; other site
742013013604	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
742013013605	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
742013013606	TM-ABC transporter signature motif; other site
742013013607	ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845
742013013608	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
742013013609	Walker A/P-loop; other site
742013013610	ATP binding site [chemical binding]; other site
742013013611	Q-loop/lid; other site
742013013612	ABC transporter signature motif; other site
742013013613	Walker B; other site
742013013614	D-loop; other site
742013013615	H-loop/switch region; other site
742013013616	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
742013013617	Transcriptional regulator [Transcription]; Region: LysR; COG0583
742013013618	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
742013013619	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
742013013620	dimerization interface [polypeptide binding]; other site
742013013621	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
742013013622	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
742013013623	ligand binding site [chemical binding]; other site
742013013624	flexible hinge region; other site
742013013625	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
742013013626	non-specific DNA interactions [nucleotide binding]; other site
742013013627	DNA binding site [nucleotide binding]
742013013628	sequence specific DNA binding site [nucleotide binding]; other site
742013013629	putative cAMP binding site [chemical binding]; other site
742013013630	PAS domain; Region: PAS_9; pfam13426
742013013631	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
742013013632	putative active site [active]
742013013633	heme pocket [chemical binding]; other site
742013013634	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
742013013635	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
742013013636	metal binding site [ion binding]; metal-binding site
742013013637	active site
742013013638	I-site; other site
742013013639	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
742013013640	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
742013013641	putative switch regulator; other site
742013013642	non-specific DNA interactions [nucleotide binding]; other site
742013013643	DNA binding site [nucleotide binding]
742013013644	sequence specific DNA binding site [nucleotide binding]; other site
742013013645	putative cAMP binding site [chemical binding]; other site
742013013646	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
742013013647	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the GGDEF (DiGuanylate-Cyclase (DGC)) domain. The GGDEF domain has been suggested to be homologous to the adenylyl cyclase catalytic domain and...; Region: CBS_pair_GGDEF_assoc; cd04598
742013013648	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
742013013649	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
742013013650	metal binding site [ion binding]; metal-binding site
742013013651	active site
742013013652	I-site; other site
742013013653	Protein of unknown function (DUF989); Region: DUF989; pfam06181
742013013654	Predicted membrane protein [Function unknown]; Region: COG3748
742013013655	Cytochrome c; Region: Cytochrom_C; pfam00034
742013013656	XdhC and CoxI family; Region: XdhC_CoxI; pfam02625
742013013657	xanthine dehydrogenase accessory protein XdhC; Region: xanthine_xdhC; TIGR02964
742013013658	XdhC Rossmann domain; Region: XdhC_C; pfam13478
742013013659	Arc-like DNA binding domain; Region: Arc; pfam03869
742013013660	The SYLF domain (also called DUF500), a novel lipid-binding module; Region: SYLF; cd11524
742013013661	putative amphipathic alpha helix; other site
742013013662	HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822
742013013663	active site
742013013664	homotetramer interface [polypeptide binding]; other site
742013013665	Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040
742013013666	Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019
742013013667	tartronate semialdehyde reductase; Provisional; Region: PRK15059
742013013668	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
742013013669	hydroxypyruvate isomerase; Region: OH-pyruv-isom; TIGR03234
742013013670	glyoxylate carboligase; Provisional; Region: PRK11269
742013013671	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
742013013672	PYR/PP interface [polypeptide binding]; other site
742013013673	dimer interface [polypeptide binding]; other site
742013013674	TPP binding site [chemical binding]; other site
742013013675	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
742013013676	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629
742013013677	TPP-binding site [chemical binding]; other site
742013013678	transcriptional regulator; Provisional; Region: PRK10632
742013013679	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
742013013680	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
742013013681	putative effector binding pocket; other site
742013013682	dimerization interface [polypeptide binding]; other site
742013013683	Putative glycerate kinase [Carbohydrate transport and metabolism]; Region: GckA; COG2379
742013013684	Domain of unknown function (DUF4147); Region: DUF4147; pfam13660
742013013685	MOFRL family; Region: MOFRL; pfam05161
742013013686	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
742013013687	Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473
742013013688	tartrate dehydrogenase; Region: TTC; TIGR02089
742013013689	Transcriptional regulator [Transcription]; Region: LysR; COG0583
742013013690	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
742013013691	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_9; cd08479
742013013692	putative effector binding pocket; other site
742013013693	putative dimerization interface [polypeptide binding]; other site
742013013694	phosphonate utilization associated transcriptional regulator; Region: phnR_burk; TIGR03338
742013013695	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
742013013696	DNA-binding site [nucleotide binding]; DNA binding site
742013013697	FCD domain; Region: FCD; pfam07729
742013013698	putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212
742013013699	Catalytic domain of bacterial PuuE allantoinases, Schizosaccharomyces pombe chitin deacetylase 1 (SpCDA1), and similar proteins; Region: CE4_PuuE_SpCDA1; cd10977
742013013700	active site
742013013701	catalytic site [active]
742013013702	tetramer interface [polypeptide binding]; other site
742013013703	putative bifunctional OHCU decarboxylase/allantoate amidohydrolase; Provisional; Region: PRK13590
742013013704	OHCU decarboxylase; Region: OHCU_decarbox; pfam09349
742013013705	M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884
742013013706	active site
742013013707	metal binding site [ion binding]; metal-binding site
742013013708	dimer interface [polypeptide binding]; other site
742013013709	succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK08651
742013013710	M20 Zn-peptidases include exopeptidases; Region: M20_like; cd02697
742013013711	putative metal binding site [ion binding]; other site
742013013712	xanthine permease; Region: pbuX; TIGR03173
742013013713	bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232
742013013714	Malic enzyme, N-terminal domain; Region: malic; pfam00390
742013013715	NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311
742013013716	putative NAD(P) binding site [chemical binding]; other site
742013013717	Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280
742013013718	Protein of unknown function (DUF4065); Region: DUF4065; pfam13274
742013013719	NAD-dependent DNA ligase (contains BRCT domain type II) [DNA replication, recombination, and repair]; Region: Lig; COG0272
742013013720	Mu-like prophage protein Com; Region: Mu-like_Com; cl11540
742013013721	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231
742013013722	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
742013013723	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
742013013724	putative transporter; Provisional; Region: PRK12382
742013013725	Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375
742013013726	Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193
742013013727	FAD binding pocket [chemical binding]; other site
742013013728	FAD binding motif [chemical binding]; other site
742013013729	phosphate binding motif [ion binding]; other site
742013013730	NAD binding pocket [chemical binding]; other site
742013013731	hypothetical protein; Provisional; Region: PRK06102
742013013732	Amidase; Region: Amidase; cl11426
742013013733	Catalytic domain of Helicobacter pylori peptidoglycan deacetylase (HpPgdA) and similar proteins; Region: CE4_HpPgdA_like; cd10938
742013013734	active site
742013013735	catalytic site [active]
742013013736	Zn binding site [ion binding]; other site
742013013737	tetramer interface [polypeptide binding]; other site
742013013738	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
742013013739	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
742013013740	benzoate transport; Region: 2A0115; TIGR00895
742013013741	putative substrate translocation pore; other site
742013013742	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
742013013743	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
742013013744	NAD(P) binding site [chemical binding]; other site
742013013745	active site
742013013746	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
742013013747	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
742013013748	NAD(P) binding site [chemical binding]; other site
742013013749	active site
742013013750	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
742013013751	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
742013013752	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683
742013013753	Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687
742013013754	Transcriptional regulators [Transcription]; Region: GntR; COG1802
742013013755	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
742013013756	DNA-binding site [nucleotide binding]; DNA binding site
742013013757	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414
742013013758	DNA-binding site [nucleotide binding]; DNA binding site
742013013759	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
742013013760	TPR repeat; Region: TPR_11; pfam13414
742013013761	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
742013013762	binding surface
742013013763	TPR motif; other site
742013013764	SnoaL-like domain; Region: SnoaL_3; pfam13474
742013013765	Ice-binding protein, left-handed beta-roll; Region: LbR_Ice_bind; cd12796
742013013766	putative water-binding motif; other site
742013013767	putative trimer interface [polypeptide binding]; other site
742013013768	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
742013013769	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
742013013770	ligand binding site [chemical binding]; other site
742013013771	UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770
742013013772	type I secretion system ABC transporter, PrtD family; Region: type_I_sec_PrtD; TIGR01842
742013013773	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
742013013774	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
742013013775	Walker A/P-loop; other site
742013013776	ATP binding site [chemical binding]; other site
742013013777	Q-loop/lid; other site
742013013778	ABC transporter signature motif; other site
742013013779	Walker B; other site
742013013780	D-loop; other site
742013013781	H-loop/switch region; other site
742013013782	type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843
742013013783	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
742013013784	HlyD family secretion protein; Region: HlyD_3; pfam13437
742013013785	type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844
742013013786	Flp pilus assembly protein, pilin Flp [Intracellular trafficking and secretion]; Region: Flp; COG3847
742013013787	Flp pilus assembly protein, pilin Flp [Intracellular trafficking and secretion]; Region: Flp; COG3847
742013013788	Flp pilus assembly protein, protease CpaA [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: CpaA; COG4960
742013013789	Domains similar to fish antifreeze type III protein; Region: SAF; cl00555
742013013790	Pilus formation protein N terminal region; Region: T2SS-T3SS_pil_N; pfam13629
742013013791	Flp pilus assembly protein, secretin CpaC [Intracellular trafficking and secretion]; Region: CpaC; COG4964
742013013792	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
742013013793	AAA domain; Region: AAA_31; pfam13614
742013013794	Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962
742013013795	Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130
742013013796	ATP binding site [chemical binding]; other site
742013013797	Walker A motif; other site
742013013798	hexamer interface [polypeptide binding]; other site
742013013799	Walker B motif; other site
742013013800	Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965
742013013801	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
742013013802	Flp pilus assembly protein TadC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: TadC; COG2064
742013013803	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
742013013804	TPR repeat; Region: TPR_11; pfam13414
742013013805	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
742013013806	TPR motif; other site
742013013807	TPR repeat; Region: TPR_11; pfam13414
742013013808	binding surface
742013013809	Protein of unknown function (DUF3613); Region: DUF3613; pfam12266
742013013810	Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961
742013013811	TadE-like protein; Region: TadE; pfam07811
742013013812	Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961
742013013813	TadE-like protein; Region: TadE; pfam07811
742013013814	Putative Tad-like Flp pilus-assembly; Region: Tad_C; pfam09977
742013013815	Predicted membrane protein [Function unknown]; Region: COG4655
742013013816	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221
742013013817	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
742013013818	Walker A motif; other site
742013013819	ATP binding site [chemical binding]; other site
742013013820	Walker B motif; other site
742013013821	arginine finger; other site
742013013822	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
742013013823	This family is most closely related to the GT1 family of glycosyltransferases. ExpC in Rhizobium meliloti has been shown to be involved in the biosynthesis of galactoglucan (exopolysaccharide II); Region: GT1_ExpC_like; cd03818
742013013824	putative ADP-binding pocket [chemical binding]; other site
742013013825	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
742013013826	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
742013013827	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
742013013828	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
742013013829	dimer interface [polypeptide binding]; other site
742013013830	phosphorylation site [posttranslational modification]
742013013831	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
742013013832	ATP binding site [chemical binding]; other site
742013013833	G-X-G motif; other site
742013013834	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
742013013835	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
742013013836	active site
742013013837	phosphorylation site [posttranslational modification]
742013013838	intermolecular recognition site; other site
742013013839	dimerization interface [polypeptide binding]; other site
742013013840	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
742013013841	Walker A motif; other site
742013013842	ATP binding site [chemical binding]; other site
742013013843	Walker B motif; other site
742013013844	arginine finger; other site
742013013845	Protein of unknown function, DUF486; Region: DUF486; cl01236
742013013846	DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases.  They exists as monomers and homodimers; Region: NUC; cd00091
742013013847	DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892
742013013848	active site
742013013849	substrate binding site [chemical binding]; other site
742013013850	Mg2+ binding site [ion binding]; other site
742013013851	Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740
742013013852	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
742013013853	oligomer interface [polypeptide binding]; other site
742013013854	active site residues [active]
742013013855	Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814
742013013856	putative hydrophobic ligand binding site [chemical binding]; other site
742013013857	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
742013013858	dimerization interface [polypeptide binding]; other site
742013013859	putative DNA binding site [nucleotide binding]; other site
742013013860	putative Zn2+ binding site [ion binding]; other site
742013013861	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
742013013862	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
742013013863	non-specific DNA binding site [nucleotide binding]; other site
742013013864	salt bridge; other site
742013013865	sequence-specific DNA binding site [nucleotide binding]; other site
742013013866	Bacillus subtilis YydB and related proteins, metallophosphatase domain; Region: MPP_YydB; cd07400
742013013867	putative active site [active]
742013013868	putative metal binding site [ion binding]; other site
742013013869	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
742013013870	Transcriptional regulator [Transcription]; Region: LysR; COG0583
742013013871	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
742013013872	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
742013013873	dimerization interface [polypeptide binding]; other site
742013013874	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
742013013875	classical (c) SDRs; Region: SDR_c; cd05233
742013013876	NAD(P) binding site [chemical binding]; other site
742013013877	active site
742013013878	luciferase-type oxidoreductase, BA3436 family; Region: lucif_BA3436; TIGR03571
742013013879	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
742013013880	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
742013013881	GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048
742013013882	C-terminal domain interface [polypeptide binding]; other site
742013013883	GSH binding site (G-site) [chemical binding]; other site
742013013884	dimer interface [polypeptide binding]; other site
742013013885	C-terminal, alpha helical domain of Ure2p and related Glutathione S-transferase-like proteins; Region: GST_C_Ure2p_like; cd03178
742013013886	dimer interface [polypeptide binding]; other site
742013013887	N-terminal domain interface [polypeptide binding]; other site
742013013888	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
742013013889	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
742013013890	The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432
742013013891	dimerization interface [polypeptide binding]; other site
742013013892	substrate binding pocket [chemical binding]; other site
742013013893	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
742013013894	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
742013013895	DNA binding residues [nucleotide binding]
742013013896	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
742013013897	CoenzymeA binding site [chemical binding]; other site
742013013898	subunit interaction site [polypeptide binding]; other site
742013013899	PHB binding site; other site
742013013900	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
742013013901	phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12755
742013013902	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
742013013903	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
742013013904	DNA-binding site [nucleotide binding]; DNA binding site
742013013905	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
742013013906	The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866
742013013907	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
742013013908	3-hydroxybutyrate dehydrogenase; Provisional; Region: PRK12429
742013013909	NAD(P) binding site [chemical binding]; other site
742013013910	active site
742013013911	fumarylacetoacetase; Region: fum_ac_acetase; TIGR01266
742013013912	Domain of unknown function (DUF1969); Region: DUF1969; pfam09298
742013013913	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
742013013914	Sporulation related domain; Region: SPOR; pfam05036
742013013915	Peptidase inhibitor I78 family; Region: Inhibitor_I78; pfam11720
742013013916	coproporphyrinogen III oxidase; Provisional; Region: PRK08898
742013013917	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
742013013918	FeS/SAM binding site; other site
742013013919	HemN C-terminal domain; Region: HemN_C; pfam06969
742013013920	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
742013013921	active site
742013013922	dimerization interface [polypeptide binding]; other site
742013013923	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
742013013924	Protein phosphatase 2C; Region: PP2C; pfam00481
742013013925	active site
742013013926	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
742013013927	Catalytic domain of Protein Kinases; Region: PKc; cd00180
742013013928	active site
742013013929	ATP binding site [chemical binding]; other site
742013013930	substrate binding site [chemical binding]; other site
742013013931	activation loop (A-loop); other site
742013013932	hypothetical protein; Provisional; Region: PRK11820
742013013933	YicC-like family, N-terminal region; Region: YicC_N; pfam03755
742013013934	Domain of unknown function (DUF1732); Region: DUF1732; pfam08340
742013013935	Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194
742013013936	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
742013013937	catalytic site [active]
742013013938	G-X2-G-X-G-K; other site
742013013939	DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392
742013013940	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
742013013941	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
742013013942	Zn2+ binding site [ion binding]; other site
742013013943	Mg2+ binding site [ion binding]; other site
742013013944	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
742013013945	synthetase active site [active]
742013013946	metal binding site [ion binding]; metal-binding site
742013013947	NTP binding site [chemical binding]; other site
742013013948	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
742013013949	ACT domain; Region: ACT_4; pfam13291
742013013950	NAD-dependent protein deacetylases, SIR2 family [Transcription]; Region: SIR2; COG0846
742013013951	SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195
742013013952	Transglycosylase SLT domain; Region: SLT_2; pfam13406
742013013953	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
742013013954	N-acetyl-D-glucosamine binding site [chemical binding]; other site
742013013955	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
742013013956	transcription elongation factor GreB; Reviewed; Region: greB; PRK01885
742013013957	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
742013013958	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
742013013959	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
742013013960	DNA-binding site [nucleotide binding]; DNA binding site
742013013961	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
742013013962	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
742013013963	pyridoxal 5'-phosphate binding site [chemical binding]; other site
742013013964	homodimer interface [polypeptide binding]; other site
742013013965	catalytic residue [active]
742013013966	gamma-aminobutyrate permease; Region: GABAperm; TIGR01773
742013013967	SnoaL-like domain; Region: SnoaL_2; pfam12680
742013013968	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
742013013969	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
742013013970	Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454
742013013971	apolar tunnel; other site
742013013972	heme binding site [chemical binding]; other site
742013013973	dimerization interface [polypeptide binding]; other site
742013013974	Transcriptional regulator [Transcription]; Region: LysR; COG0583
742013013975	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
742013013976	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_7; cd08476
742013013977	putative effector binding pocket; other site
742013013978	putative dimerization interface [polypeptide binding]; other site
742013013979	FtsX-like permease family; Region: FtsX; pfam02687
742013013980	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
742013013981	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
742013013982	trimer interface [polypeptide binding]; other site
742013013983	eyelet of channel; other site
742013013984	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
742013013985	Clavaminic acid synthetase (CAS) -like;  CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184
742013013986	Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175
742013013987	substrate binding pocket [chemical binding]; other site
742013013988	active site
742013013989	iron coordination sites [ion binding]; other site
742013013990	Prokaryotic protein of unknown function (DUF849); Region: DUF849; pfam05853
742013013991	Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625
742013013992	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
742013013993	quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754
742013013994	Quinone oxidoreductase (QOR); Region: QOR2; cd05286
742013013995	NADP binding site [chemical binding]; other site
742013013996	dimer interface [polypeptide binding]; other site
742013013997	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181
742013013998	Prokaryotic protein of unknown function (DUF849); Region: DUF849; pfam05853
742013013999	Clavaminic acid synthetase (CAS) -like;  CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184
742013014000	Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175
742013014001	substrate binding pocket [chemical binding]; other site
742013014002	active site
742013014003	iron coordination sites [ion binding]; other site
742013014004	Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625
742013014005	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
742013014006	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
742013014007	nitrite reductase subunit NirD; Provisional; Region: PRK14989
742013014008	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
742013014009	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
742013014010	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
742013014011	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
742013014012	Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529
742013014013	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
742013014014	Coenzyme A binding pocket [chemical binding]; other site
742013014015	Low molecular weight phosphatase family; Region: LMWPc; cd00115
742013014016	Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451
742013014017	active site
742013014018	PAS domain; Region: PAS_9; pfam13426
742013014019	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
742013014020	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
742013014021	metal binding site [ion binding]; metal-binding site
742013014022	active site
742013014023	I-site; other site
742013014024	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
742013014025	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
742013014026	N-terminal plug; other site
742013014027	ligand-binding site [chemical binding]; other site
742013014028	SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968
742013014029	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
742013014030	Cu(I) binding site [ion binding]; other site
742013014031	3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427
742013014032	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
742013014033	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
742013014034	Cobalamin biosynthesis protein CobT; Region: CobT; pfam06213
742013014035	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
742013014036	metal ion-dependent adhesion site (MIDAS); other site
742013014037	Cobaltochelatase CobS subunit N terminal; Region: CobS_N; pfam12556
742013014038	cobaltochelatase, CobS subunit; Region: PD_CobS; TIGR01650
742013014039	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
742013014040	Transcriptional regulator [Transcription]; Region: IclR; COG1414
742013014041	IclR helix-turn-helix domain; Region: HTH_IclR; cl17605
742013014042	Bacterial transcriptional regulator; Region: IclR; pfam01614
742013014043	sulfoacetaldehyde acetyltransferase; Validated; Region: PRK07525
742013014044	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
742013014045	PYR/PP interface [polypeptide binding]; other site
742013014046	dimer interface [polypeptide binding]; other site
742013014047	TPP binding site [chemical binding]; other site
742013014048	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
742013014049	Thiamine pyrophosphate (TPP) family, Xsc-like subfamily, TPP-binding module; composed of proteins similar to Alcaligenes defragrans sulfoacetaldehyde acetyltransferase (Xsc). Xsc plays a key role in the degradation of taurine, catalyzing the...; Region: TPP_Xsc_like; cd02013
742013014050	TPP-binding site; other site
742013014051	Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl17212
742013014052	Predicted membrane protein [Function unknown]; Region: COG2855
742013014053	Transcriptional regulator [Transcription]; Region: LysR; COG0583
742013014054	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
742013014055	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
742013014056	dimerization interface [polypeptide binding]; other site
742013014057	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
742013014058	atypical (a) SDRs, subgroup 3; Region: SDR_a3; cd05229
742013014059	putative NAD(P) binding site [chemical binding]; other site
742013014060	putative active site [active]
742013014061	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
742013014062	CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492
742013014063	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833
742013014064	Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574
742013014065	YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300
742013014066	active site
742013014067	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
742013014068	Na binding site [ion binding]; other site
742013014069	Protein of unknown function (DUF3311); Region: DUF3311; pfam11755
742013014070	Transcriptional regulator [Transcription]; Region: LysR; COG0583
742013014071	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
742013014072	LysR substrate binding domain; Region: LysR_substrate; pfam03466
742013014073	dimerization interface [polypeptide binding]; other site
742013014074	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
742013014075	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
742013014076	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
742013014077	dimerization interface [polypeptide binding]; other site
742013014078	4-hydroxythreonine-4-phosphate dehydrogenase; Region: pdxA; TIGR00557
742013014079	4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743
742013014080	Protein of unknown function (DUF1304); Region: DUF1304; pfam06993
742013014081	PRC-barrel domain; Region: PRC; pfam05239
742013014082	Cysteine-rich 4 helical bundle widely conserved in bacteria; Region: DUF326; cd08026
742013014083	dimerization interface [polypeptide binding]; other site
742013014084	H-NS histone family; Region: Histone_HNS; pfam00816
742013014085	Domain in histone-like proteins of HNS family; Region: HNS; smart00528
742013014086	seryl-tRNA synthetase; Provisional; Region: PRK05431
742013014087	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
742013014088	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770
742013014089	dimer interface [polypeptide binding]; other site
742013014090	active site
742013014091	motif 1; other site
742013014092	motif 2; other site
742013014093	motif 3; other site
742013014094	FOG: CBS domain [General function prediction only]; Region: COG0517
742013014095	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205
742013014096	4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761
742013014097	4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045
742013014098	FKBP-type peptidyl-prolyl cis-trans isomerases 2 [Posttranslational modification, protein turnover, chaperones]; Region: SlpA; COG1047
742013014099	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
742013014100	hypothetical protein; Reviewed; Region: PRK00024
742013014101	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
742013014102	MPN+ (JAMM) motif; other site
742013014103	Zinc-binding site [ion binding]; other site
742013014104	RNA polymerase sigma factor; Provisional; Region: PRK12528
742013014105	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
742013014106	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
742013014107	DNA binding residues [nucleotide binding]
742013014108	Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712
742013014109	FecR protein; Region: FecR; pfam04773
742013014110	Secretin and TonB N terminus short domain; Region: STN; smart00965
742013014111	Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion transport and metabolism]; Region: FhuE; COG4773
742013014112	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
742013014113	N-terminal plug; other site
742013014114	ligand-binding site [chemical binding]; other site
742013014115	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840
742013014116	Smr domain; Region: Smr; pfam01713
742013014117	Major Facilitator Superfamily; Region: MFS_1; pfam07690
742013014118	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl17904
742013014119	Transcriptional regulators [Transcription]; Region: MarR; COG1846
742013014120	Winged helix DNA-binding domain; Region: HTH_27; pfam13463
742013014121	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
742013014122	CoenzymeA binding site [chemical binding]; other site
742013014123	subunit interaction site [polypeptide binding]; other site
742013014124	PHB binding site; other site
742013014125	bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase periplasmic precursor protein; Reviewed; Region: cpdB; PRK09420
742013014126	Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410
742013014127	active site
742013014128	metal binding site [ion binding]; metal-binding site
742013014129	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
742013014130	DNA-binding transcriptional regulator CynR; Provisional; Region: PRK11242
742013014131	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
742013014132	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
742013014133	dimerization interface [polypeptide binding]; other site
742013014134	Transcriptional regulator [Transcription]; Region: LysR; COG0583
742013014135	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
742013014136	The C-terminal substrate binding domain of LysR-type transcrptional regulator BudR, which is responsible for activation of the expression of the butanediol operon genes; contains the type 2 periplasmic binding fold; Region: PBP2_BudR; cd08451
742013014137	putative dimerization interface [polypeptide binding]; other site
742013014138	putative substrate binding pocket [chemical binding]; other site
742013014139	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
742013014140	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
742013014141	EamA-like transporter family; Region: EamA; pfam00892
742013014142	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
742013014143	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
742013014144	DNA-binding site [nucleotide binding]; DNA binding site
742013014145	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
742013014146	pyridoxal 5'-phosphate binding site [chemical binding]; other site
742013014147	homodimer interface [polypeptide binding]; other site
742013014148	catalytic residue [active]
742013014149	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
742013014150	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
742013014151	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
742013014152	putative substrate translocation pore; other site
742013014153	Secretin and TonB N terminus short domain; Region: STN; smart00965
742013014154	Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion transport and metabolism]; Region: FhuE; COG4773
742013014155	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
742013014156	N-terminal plug; other site
742013014157	ligand-binding site [chemical binding]; other site
742013014158	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
742013014159	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
742013014160	N-terminal plug; other site
742013014161	ligand-binding site [chemical binding]; other site
742013014162	Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182
742013014163	PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172
742013014164	Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413
742013014165	PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703
742013014166	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
742013014167	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
742013014168	active site
742013014169	phosphorylation site [posttranslational modification]
742013014170	intermolecular recognition site; other site
742013014171	dimerization interface [polypeptide binding]; other site
742013014172	Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762
742013014173	DNA binding residues [nucleotide binding]
742013014174	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
742013014175	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736
742013014176	active site
742013014177	phosphorylation site [posttranslational modification]
742013014178	intermolecular recognition site; other site
742013014179	dimerization interface [polypeptide binding]; other site
742013014180	Response regulator receiver domain; Region: Response_reg; pfam00072
742013014181	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
742013014182	active site
742013014183	phosphorylation site [posttranslational modification]
742013014184	intermolecular recognition site; other site
742013014185	dimerization interface [polypeptide binding]; other site
742013014186	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
742013014187	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
742013014188	substrate binding pocket [chemical binding]; other site
742013014189	membrane-bound complex binding site; other site
742013014190	hinge residues; other site
742013014191	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
742013014192	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
742013014193	putative active site [active]
742013014194	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
742013014195	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
742013014196	putative active site [active]
742013014197	heme pocket [chemical binding]; other site
742013014198	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
742013014199	dimer interface [polypeptide binding]; other site
742013014200	phosphorylation site [posttranslational modification]
742013014201	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
742013014202	ATP binding site [chemical binding]; other site
742013014203	Mg2+ binding site [ion binding]; other site
742013014204	G-X-G motif; other site
742013014205	DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595
742013014206	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
742013014207	DNA binding residues [nucleotide binding]
742013014208	Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712
742013014209	FecR protein; Region: FecR; pfam04773
742013014210	Secretin and TonB N terminus short domain; Region: STN; smart00965
742013014211	Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion transport and metabolism]; Region: FhuE; COG4773
742013014212	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
742013014213	N-terminal plug; other site
742013014214	ligand-binding site [chemical binding]; other site
742013014215	muconate and chloromuconate cycloisomerases; Region: mucon_cyclo; TIGR02534
742013014216	Muconate Lactonizing Enzyme (MLE), an homooctameric enzyme, catalyses the conversion of cis,cis-muconate (CCM) to muconolactone (ML) in the catechol branch of the beta-ketoadipate pathway. This pathway is used in soil microbes to breakdown lignin-derived...; Region: MLE; cd03318
742013014217	octamer interface [polypeptide binding]; other site
742013014218	active site
742013014219	muconolactone delta-isomerase; Region: muco_delta; TIGR03221
742013014220	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
742013014221	EamA-like transporter family; Region: EamA; pfam00892
742013014222	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
742013014223	EamA-like transporter family; Region: EamA; pfam00892
742013014224	Transcriptional regulator [Transcription]; Region: LysR; COG0583
742013014225	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
742013014226	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
742013014227	dimerization interface [polypeptide binding]; other site
742013014228	NADH-dependant formate dehydrogenase delta subunit FdsD; Region: FdsD; pfam11390
742013014229	Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383
742013014230	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
742013014231	catalytic loop [active]
742013014232	iron binding site [ion binding]; other site
742013014233	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588
742013014234	Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753
742013014235	[4Fe-4S] binding site [ion binding]; other site
742013014236	molybdopterin cofactor binding site; other site
742013014237	This CD includes formate dehydrogenases (Fdh) H and N; nitrate reductases, Nap and Nas; and other related proteins. Formate dehydrogenase H is a component of the anaerobic formate hydrogen lyase complex  and catalyzes the reversible oxidation of formate...; Region: MopB_CT_Fdh-Nap-like; cd00508
742013014238	molybdopterin cofactor binding site; other site
742013014239	formate dehydrogenase subunit gamma; Validated; Region: PRK05988
742013014240	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily, NAD-dependent formate dehydrogenase (FDH) gamma subunit; composed of proteins similar to the gamma subunit of NAD-linked FDH of Ralstonia eutropha, a...; Region: TRX_Fd_NuoE_FDH_gamma; cd03081
742013014241	putative dimer interface [polypeptide binding]; other site
742013014242	[2Fe-2S] cluster binding site [ion binding]; other site
742013014243	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
742013014244	NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894
742013014245	SLBB domain; Region: SLBB; pfam10531
742013014246	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928
742013014247	Transcriptional regulators [Transcription]; Region: MarR; COG1846
742013014248	Winged helix DNA-binding domain; Region: HTH_27; pfam13463
742013014249	benzoate transport; Region: 2A0115; TIGR00895
742013014250	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
742013014251	putative substrate translocation pore; other site
742013014252	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
742013014253	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
742013014254	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
742013014255	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
742013014256	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
742013014257	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
742013014258	catalytic loop [active]
742013014259	iron binding site [ion binding]; other site
742013014260	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
742013014261	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
742013014262	Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518
742013014263	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
742013014264	Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309
742013014265	N-carbamoylsarcosine amidohydrolase (CSHase) hydrolyzes N-carbamoylsarcosine to sarcosine, carbon dioxide and ammonia. CSHase is involved in one of the two alternative pathways for creatinine degradation to glycine in microorganisms.This...; Region: CSHase; cd01015
742013014266	Isochorismatase family; Region: Isochorismatase; pfam00857
742013014267	catalytic triad [active]
742013014268	substrate binding site [chemical binding]; other site
742013014269	domain interfaces; other site
742013014270	conserved cis-peptide bond; other site
742013014271	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
742013014272	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
742013014273	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
742013014274	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
742013014275	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
742013014276	HipA N-terminal domain; Region: Couple_hipA; cl11853
742013014277	HipA-like N-terminal domain; Region: HipA_N; pfam07805
742013014278	HipA-like C-terminal domain; Region: HipA_C; pfam07804
742013014279	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
742013014280	non-specific DNA binding site [nucleotide binding]; other site
742013014281	salt bridge; other site
742013014282	sequence-specific DNA binding site [nucleotide binding]; other site
742013014283	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
742013014284	pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424
742013014285	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
742013014286	dimerization interface [polypeptide binding]; other site
742013014287	antiporter inner membrane protein; Provisional; Region: PRK11670
742013014288	Domain of unknown function DUF59; Region: DUF59; pfam01883
742013014289	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
742013014290	Restriction endonuclease; Region: Mrr_cat; pfam04471
742013014291	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
742013014292	Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396
742013014293	nucleophile elbow; other site
742013014294	Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396
742013014295	methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133
742013014296	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
742013014297	active site
742013014298	HIGH motif; other site
742013014299	KMSKS motif; other site
742013014300	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
742013014301	anticodon binding site; other site
742013014302	tRNA binding surface [nucleotide binding]; other site
742013014303	tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins.  This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties.  MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800
742013014304	dimer interface [polypeptide binding]; other site
742013014305	putative tRNA-binding site [nucleotide binding]; other site
742013014306	Uncharacterized conserved protein [Function unknown]; Region: COG1284
742013014307	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
742013014308	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
742013014309	SmpA / OmlA family; Region: SmpA_OmlA; cl17115
742013014310	Protein of unknown function (DUF3460); Region: DUF3460; pfam11943
742013014311	Rec8/ScpA/Scc1-like protein (kleisin family) [Replication,    recombination, and repair]; Region: scpA; COG1354
742013014312	Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602
742013014313	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
742013014314	FeS/SAM binding site; other site
742013014315	6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242
742013014316	active site
742013014317	Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent  decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919
742013014318	tetramerization interface [polypeptide binding]; other site
742013014319	active site
742013014320	adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK06943
742013014321	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
742013014322	inhibitor-cofactor binding pocket; inhibition site
742013014323	pyridoxal 5'-phosphate binding site [chemical binding]; other site
742013014324	catalytic residue [active]
742013014325	AAA domain; Region: AAA_26; pfam13500
742013014326	dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090
742013014327	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
742013014328	8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958
742013014329	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
742013014330	catalytic residue [active]
742013014331	5-carboxymethyl-2-hydroxymuconate isomerase (CHMI) is a trimeric enzyme catalyzing the isomerization of the unsaturated ketone 5-(carboxymethyl)-2-hydroxymuconate to 5-(carboxymethyl)-2-oxo-3-hexene-1,6-dionate. This is one step in the...; Region: CHMI; cd00580
742013014332	putative substrate binding pocket [chemical binding]; other site
742013014333	trimer interface [polypeptide binding]; other site
742013014334	DTW domain; Region: DTW; cl01221
742013014335	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
742013014336	PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224
742013014337	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
742013014338	substrate-cofactor binding pocket; other site
742013014339	pyridoxal 5'-phosphate binding site [chemical binding]; other site
742013014340	aminodeoxychorismate synthase; Provisional; Region: PRK07508
742013014341	chorismate binding enzyme; Region: Chorismate_bind; cl10555
742013014342	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
742013014343	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
742013014344	ligand binding site [chemical binding]; other site
742013014345	flexible hinge region; other site
742013014346	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
742013014347	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
742013014348	Walker A/P-loop; other site
742013014349	ATP binding site [chemical binding]; other site
742013014350	Q-loop/lid; other site
742013014351	ABC transporter signature motif; other site
742013014352	Walker B; other site
742013014353	D-loop; other site
742013014354	H-loop/switch region; other site
742013014355	Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557
742013014356	oligomerization interface [polypeptide binding]; other site
742013014357	active site
742013014358	metal binding site [ion binding]; metal-binding site
742013014359	Pantoate-beta-alanine ligase; Region: PanC; cd00560
742013014360	pantoate--beta-alanine ligase; Region: panC; TIGR00018
742013014361	active site
742013014362	ATP-binding site [chemical binding]; other site
742013014363	pantoate-binding site; other site
742013014364	HXXH motif; other site
742013014365	Protein of unknown function (DUF3079); Region: DUF3079; pfam11278
742013014366	DNA-binding transcriptional regulator LysR; Provisional; Region: PRK11013
742013014367	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
742013014368	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
742013014369	dimerization interface [polypeptide binding]; other site
742013014370	diaminopimelate decarboxylase; Provisional; Region: PRK11165
742013014371	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
742013014372	active site
742013014373	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
742013014374	substrate binding site [chemical binding]; other site
742013014375	catalytic residues [active]
742013014376	dimer interface [polypeptide binding]; other site
742013014377	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094
742013014378	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
742013014379	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
742013014380	preprotein translocase subunit SecB; Validated; Region: PRK05751
742013014381	SecA binding site; other site
742013014382	Preprotein binding site; other site
742013014383	Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418
742013014384	GSH binding site [chemical binding]; other site
742013014385	catalytic residues [active]
742013014386	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
742013014387	active site residue [active]
742013014388	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
742013014389	catalytic core [active]
742013014390	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
742013014391	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
742013014392	C-terminal peptidase (prc); Region: prc; TIGR00225
742013014393	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
742013014394	protein binding site [polypeptide binding]; other site
742013014395	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
742013014396	Catalytic dyad [active]
742013014397	molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690
742013014398	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
742013014399	ATP binding site [chemical binding]; other site
742013014400	substrate interface [chemical binding]; other site
742013014401	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
742013014402	Response regulator receiver domain; Region: Response_reg; pfam00072
742013014403	active site
742013014404	phosphorylation site [posttranslational modification]
742013014405	intermolecular recognition site; other site
742013014406	dimerization interface [polypeptide binding]; other site
742013014407	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
742013014408	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
742013014409	active site
742013014410	phosphorylation site [posttranslational modification]
742013014411	intermolecular recognition site; other site
742013014412	dimerization interface [polypeptide binding]; other site
742013014413	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
742013014414	DNA binding residues [nucleotide binding]
742013014415	dimerization interface [polypeptide binding]; other site
742013014416	CHASE3 domain; Region: CHASE3; pfam05227
742013014417	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
742013014418	Histidine kinase; Region: HisKA_3; pfam07730
742013014419	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
742013014420	ATP binding site [chemical binding]; other site
742013014421	Mg2+ binding site [ion binding]; other site
742013014422	G-X-G motif; other site
742013014423	periplasmic protein; Provisional; Region: PRK10568
742013014424	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4307
742013014425	Uncharacterized protein conserved in bacteria (DUF2248); Region: DUF2248; pfam10005
742013014426	phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168
742013014427	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
742013014428	active site
742013014429	(T/H)XGH motif; other site
742013014430	N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742
742013014431	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
742013014432	S-adenosylmethionine binding site [chemical binding]; other site
742013014433	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
742013014434	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
742013014435	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
742013014436	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
742013014437	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
742013014438	signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416
742013014439	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
742013014440	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
742013014441	CutA1 divalent ion tolerance protein; Region: CutA1; cl00584
742013014442	2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522
742013014443	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
742013014444	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
742013014445	aldolase II superfamily protein; Provisional; Region: PRK07044
742013014446	intersubunit interface [polypeptide binding]; other site
742013014447	active site
742013014448	Zn2+ binding site [ion binding]; other site
742013014449	Transcriptional regulators [Transcription]; Region: MarR; COG1846
742013014450	MarR family; Region: MarR_2; pfam12802
742013014451	MarR family; Region: MarR_2; cl17246
742013014452	Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412
742013014453	SnoaL-like domain; Region: SnoaL_2; pfam12680
742013014454	Flavin reductase like domain; Region: Flavin_Reduct; smart00903
742013014455	short chain dehydrogenase; Provisional; Region: PRK08265
742013014456	classical (c) SDRs; Region: SDR_c; cd05233
742013014457	NAD(P) binding site [chemical binding]; other site
742013014458	active site
742013014459	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
742013014460	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
742013014461	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
742013014462	classical (c) SDRs; Region: SDR_c; cd05233
742013014463	NAD(P) binding site [chemical binding]; other site
742013014464	active site
742013014465	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421
742013014466	Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853
742013014467	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_9; cd07245
742013014468	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
742013014469	dimer interface [polypeptide binding]; other site
742013014470	putative metal binding site [ion binding]; other site
742013014471	MarR family; Region: MarR_2; cl17246
742013014472	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
742013014473	NLPA lipoprotein; Region: Lipoprotein_9; pfam03180
742013014474	NLPA lipoprotein; Region: Lipoprotein_9; pfam03180
742013014475	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
742013014476	ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258
742013014477	Walker A/P-loop; other site
742013014478	ATP binding site [chemical binding]; other site
742013014479	Q-loop/lid; other site
742013014480	ABC transporter signature motif; other site
742013014481	Walker B; other site
742013014482	D-loop; other site
742013014483	H-loop/switch region; other site
742013014484	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
742013014485	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
742013014486	dimer interface [polypeptide binding]; other site
742013014487	conserved gate region; other site
742013014488	ABC-ATPase subunit interface; other site
742013014489	sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022
742013014490	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
742013014491	active site
742013014492	sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022
742013014493	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
742013014494	active site
742013014495	NLPA lipoprotein; Region: Lipoprotein_9; pfam03180
742013014496	FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860
742013014497	nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095
742013014498	active site
742013014499	non-prolyl cis peptide bond; other site
742013014500	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
742013014501	sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022
742013014502	active site
742013014503	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
742013014504	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
742013014505	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
742013014506	sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022
742013014507	active site
742013014508	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
742013014509	psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974
742013014510	Walker A motif; other site
742013014511	ATP binding site [chemical binding]; other site
742013014512	Walker B motif; other site
742013014513	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
742013014514	alkanesulfonate monooxygenase, FMNH(2)-dependent; Region: alk_sulf_monoox; TIGR03565
742013014515	Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094
742013014516	active site
742013014517	dimer interface [polypeptide binding]; other site
742013014518	non-prolyl cis peptide bond; other site
742013014519	insertion regions; other site
742013014520	Transcriptional regulator [Transcription]; Region: LysR; COG0583
742013014521	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
742013014522	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
742013014523	dimerization interface [polypeptide binding]; other site
742013014524	Dicarboxylate carrier protein MatC N-terminus; Region: MatC_N; pfam07158
742013014525	malonate decarboxylase, alpha subunit; Region: mdcA; TIGR01110
742013014526	malonate decarboxylase acyl carrier protein; Region: malonate_delta; TIGR03130
742013014527	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189
742013014528	Malonate decarboxylase gamma subunit (MdcE); Region: MdcE; pfam06833
742013014529	Phosphoribosyl-dephospho-CoA transferase MdcG; Region: MdcG; pfam10620
742013014530	malonate decarboxylase holo-[acyl-carrier-protein] synthase; Region: malonate_mdcG; TIGR03135
742013014531	ATP:dephospho-CoA triphosphoribosyl transferase; Region: CitG; pfam01874
742013014532	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
742013014533	malonate decarboxylase, epsilon subunit; Region: malonate_mdcH; TIGR03131
742013014534	acetyl-CoA synthetase; Provisional; Region: PRK00174
742013014535	Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966
742013014536	active site
742013014537	CoA binding site [chemical binding]; other site
742013014538	acyl-activating enzyme (AAE) consensus motif; other site
742013014539	AMP binding site [chemical binding]; other site
742013014540	acetate binding site [chemical binding]; other site
742013014541	Uncharacterized protein involved in propionate catabolism [General function prediction only]; Region: PrpD; COG2079
742013014542	Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042
742013014543	CoA binding domain; Region: CoA_binding_2; pfam13380
742013014544	Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607
742013014545	ATP-grasp domain; Region: ATP-grasp_5; pfam13549
742013014546	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
742013014547	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
742013014548	substrate binding site [chemical binding]; other site
742013014549	oxyanion hole (OAH) forming residues; other site
742013014550	trimer interface [polypeptide binding]; other site
742013014551	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
742013014552	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
742013014553	Transcriptional regulator [Transcription]; Region: IclR; COG1414
742013014554	Bacterial transcriptional regulator; Region: IclR; pfam01614
742013014555	RNA polymerase factor sigma-32; Reviewed; Region: PRK06596
742013014556	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
742013014557	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
742013014558	DNA binding residues [nucleotide binding]
742013014559	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
742013014560	Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000
742013014561	Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116
742013014562	Fatty acid desaturase; Region: FA_desaturase; pfam00487
742013014563	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK06816
742013014564	"initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827
742013014565	dimer interface [polypeptide binding]; other site
742013014566	active site
742013014567	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
742013014568	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
742013014569	ligand binding site [chemical binding]; other site
742013014570	PAS domain S-box; Region: sensory_box; TIGR00229
742013014571	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
742013014572	putative active site [active]
742013014573	heme pocket [chemical binding]; other site
742013014574	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
742013014575	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
742013014576	metal binding site [ion binding]; metal-binding site
742013014577	active site
742013014578	I-site; other site
742013014579	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
742013014580	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
742013014581	PAS domain; Region: PAS_9; pfam13426
742013014582	putative active site [active]
742013014583	heme pocket [chemical binding]; other site
742013014584	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
742013014585	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
742013014586	dimer interface [polypeptide binding]; other site
742013014587	putative CheW interface [polypeptide binding]; other site
742013014588	Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999
742013014589	SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968
742013014590	Cu(I) binding site [ion binding]; other site
742013014591	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
742013014592	SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662
742013014593	Protein of unknown function (DUF2909); Region: DUF2909; pfam11137
742013014594	Cytochrome c oxidase subunit III.  Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_III; cd01665
742013014595	Subunit III/VIIa interface [polypeptide binding]; other site
742013014596	Phospholipid binding site [chemical binding]; other site
742013014597	Subunit I/III interface [polypeptide binding]; other site
742013014598	Subunit III/VIb interface [polypeptide binding]; other site
742013014599	Subunit III/VIa interface; other site
742013014600	Subunit III/Vb interface [polypeptide binding]; other site
742013014601	Protein of unknown function (DUF2970); Region: DUF2970; pfam11174
742013014602	cytochrome C oxidase assembly protein; Provisional; Region: PRK05089
742013014603	cytochrome c oxidase subunit I; Validated; Region: COX1; MTH00007
742013014604	Cytochrome C oxidase subunit I.  Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_I; cd01663
742013014605	Subunit I/III interface [polypeptide binding]; other site
742013014606	D-pathway; other site
742013014607	Subunit I/VIIc interface [polypeptide binding]; other site
742013014608	Subunit I/IV interface [polypeptide binding]; other site
742013014609	Subunit I/II interface [polypeptide binding]; other site
742013014610	Low-spin heme (heme a) binding site [chemical binding]; other site
742013014611	Subunit I/VIIa interface [polypeptide binding]; other site
742013014612	Subunit I/VIa interface [polypeptide binding]; other site
742013014613	Dimer interface; other site
742013014614	Putative water exit pathway; other site
742013014615	Binuclear center (heme a3/CuB) [ion binding]; other site
742013014616	K-pathway; other site
742013014617	Subunit I/Vb interface [polypeptide binding]; other site
742013014618	Putative proton exit pathway; other site
742013014619	Subunit I/VIb interface; other site
742013014620	Subunit I/VIc interface [polypeptide binding]; other site
742013014621	Electron transfer pathway; other site
742013014622	Subunit I/VIIIb interface [polypeptide binding]; other site
742013014623	Subunit I/VIIb interface [polypeptide binding]; other site
742013014624	cytochrome c oxidase subunit II; Validated; Region: COX2; MTH00023
742013014625	Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790
742013014626	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
742013014627	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
742013014628	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
742013014629	biotin biosynthesis protein BioC; Region: BioC; TIGR02072
742013014630	Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040
742013014631	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
742013014632	active site
742013014633	Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219
742013014634	Domain of unknown function (DUF4148); Region: DUF4148; pfam13663
742013014635	NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit.  Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450
742013014636	putative active site [active]
742013014637	putative catalytic site [active]
742013014638	LysE type translocator; Region: LysE; cl00565
742013014639	glutathione-regulated potassium-efflux system protein KefC; Provisional; Region: PRK03562
742013014640	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
742013014641	TrkA-N domain; Region: TrkA_N; pfam02254
742013014642	Transcriptional regulator [Transcription]; Region: LysR; COG0583
742013014643	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
742013014644	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
742013014645	dimerization interface [polypeptide binding]; other site
742013014646	Lin1944 and related proteins, classical (c) SDRs; Region: Lin1944_like_SDR_c; cd11731
742013014647	KR domain; Region: KR; pfam08659
742013014648	putative NAD(P) binding site [chemical binding]; other site
742013014649	homodimer interface [polypeptide binding]; other site
742013014650	Domain of unknown function (DUF1841); Region: DUF1841; pfam08897
742013014651	Cytochrome c553 [Energy production and conversion]; Region: COG2863
742013014652	Cytochrome c; Region: Cytochrom_C; cl11414
742013014653	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
742013014654	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
742013014655	Walker A motif; other site
742013014656	ATP binding site [chemical binding]; other site
742013014657	Walker B motif; other site
742013014658	arginine finger; other site
742013014659	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
742013014660	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3825
742013014661	Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729
742013014662	Surface antigen; Region: Bac_surface_Ag; pfam01103
742013014663	Family of unknown function (DUF490); Region: DUF490; pfam04357
742013014664	Uncharacterized conserved protein [Function unknown]; Region: COG3391
742013014665	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
742013014666	structural tetrad; other site
742013014667	IPTL-CTERM protein sorting domain; Region: IPTL_CTERM; TIGR04174
742013014668	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
742013014669	PAS domain; Region: PAS_9; pfam13426
742013014670	putative active site [active]
742013014671	heme pocket [chemical binding]; other site
742013014672	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
742013014673	PAS domain; Region: PAS_9; pfam13426
742013014674	putative active site [active]
742013014675	heme pocket [chemical binding]; other site
742013014676	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
742013014677	dimer interface [polypeptide binding]; other site
742013014678	putative CheW interface [polypeptide binding]; other site
742013014679	glutathione S-transferase; Provisional; Region: PRK15113
742013014680	Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of  glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570
742013014681	C-terminal domain interface [polypeptide binding]; other site
742013014682	GSH binding site (G-site) [chemical binding]; other site
742013014683	dimer interface [polypeptide binding]; other site
742013014684	C-terminal, alpha helical domain of an unknown subfamily 4 of Glutathione S-transferases; Region: GST_C_4; cd03195
742013014685	putative dimer interface [polypeptide binding]; other site
742013014686	N-terminal domain interface [polypeptide binding]; other site
742013014687	putative substrate binding pocket (H-site) [chemical binding]; other site
742013014688	Protein of unknown function (DUF2939); Region: DUF2939; pfam11159
742013014689	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
742013014690	Tar ligand binding domain homologue; Region: TarH; pfam02203
742013014691	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
742013014692	dimerization interface [polypeptide binding]; other site
742013014693	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
742013014694	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
742013014695	dimer interface [polypeptide binding]; other site
742013014696	putative CheW interface [polypeptide binding]; other site
742013014697	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
742013014698	GAF domain; Region: GAF_3; pfam13492
742013014699	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
742013014700	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
742013014701	metal binding site [ion binding]; metal-binding site
742013014702	active site
742013014703	I-site; other site
742013014704	heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386
742013014705	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
742013014706	dimer interface [polypeptide binding]; other site
742013014707	phosphorylation site [posttranslational modification]
742013014708	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
742013014709	ATP binding site [chemical binding]; other site
742013014710	Mg2+ binding site [ion binding]; other site
742013014711	G-X-G motif; other site
742013014712	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
742013014713	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
742013014714	active site
742013014715	phosphorylation site [posttranslational modification]
742013014716	intermolecular recognition site; other site
742013014717	dimerization interface [polypeptide binding]; other site
742013014718	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
742013014719	DNA binding site [nucleotide binding]
742013014720	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
742013014721	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
742013014722	Walker A/P-loop; other site
742013014723	ATP binding site [chemical binding]; other site
742013014724	Q-loop/lid; other site
742013014725	ABC transporter signature motif; other site
742013014726	Walker B; other site
742013014727	D-loop; other site
742013014728	H-loop/switch region; other site
742013014729	Predicted protein-tyrosine phosphatase [Signal transduction mechanisms]; Region: CDC14; COG2453
742013014730	active site
742013014731	catalytic residues [active]
742013014732	periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037
742013014733	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
742013014734	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
742013014735	protein binding site [polypeptide binding]; other site
742013014736	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
742013014737	Transcriptional regulator [Transcription]; Region: LysR; COG0583
742013014738	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
742013014739	The C-terminal substrate-binding domain of putative LysR-type transcriptional regulator PAO1-like, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_PAO1_like; cd08412
742013014740	putative substrate binding pocket [chemical binding]; other site
742013014741	dimerization interface [polypeptide binding]; other site
742013014742	flavin-dependent oxidoreductase, MSMEG_0569 family; Region: MSMEG_0569_nitr; TIGR04046
742013014743	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
742013014744	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
742013014745	homotrimer interaction site [polypeptide binding]; other site
742013014746	putative active site [active]
742013014747	acetylornithine deacetylase; Provisional; Region: PRK07522
742013014748	M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894
742013014749	metal binding site [ion binding]; metal-binding site
742013014750	putative dimer interface [polypeptide binding]; other site
742013014751	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
742013014752	Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133
742013014753	Na binding site [ion binding]; other site
742013014754	indole acetimide hydrolase; Validated; Region: PRK07488
742013014755	Amidase; Region: Amidase; cl11426
742013014756	Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034
742013014757	ArsC family; Region: ArsC; pfam03960
742013014758	catalytic residues [active]
742013014759	xanthine permease; Region: pbuX; TIGR03173
742013014760	hydroxydechloroatrazine ethylaminohydrolase; Reviewed; Region: PRK08203
742013014761	TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298
742013014762	active site
742013014763	putative substrate binding pocket [chemical binding]; other site
742013014764	Transcriptional regulator [Transcription]; Region: LysR; COG0583
742013014765	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
742013014766	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
742013014767	dimerization interface [polypeptide binding]; other site
742013014768	ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178
742013014769	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
742013014770	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
742013014771	ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259
742013014772	Walker A/P-loop; other site
742013014773	ATP binding site [chemical binding]; other site
742013014774	Q-loop/lid; other site
742013014775	ABC transporter signature motif; other site
742013014776	Walker B; other site
742013014777	D-loop; other site
742013014778	H-loop/switch region; other site
742013014779	TOBE domain; Region: TOBE_2; pfam08402
742013014780	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
742013014781	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120
742013014782	Domain of unknown function (DUF1987); Region: DUF1987; pfam09345
742013014783	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
742013014784	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
742013014785	Coenzyme A binding pocket [chemical binding]; other site
742013014786	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
742013014787	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
742013014788	putative acyl-acceptor binding pocket; other site
742013014789	dihydroorotase; Provisional; Region: PRK07627
742013014790	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
742013014791	Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317
742013014792	active site
742013014793	aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856
742013014794	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
742013014795	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
742013014796	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
742013014797	active site
742013014798	Holliday junction resolvase-like protein; Reviewed; Region: PRK00109
742013014799	hypothetical protein; Validated; Region: PRK00228
742013014800	Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415
742013014801	DNA photolyase; Region: DNA_photolyase; pfam00875
742013014802	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
742013014803	putative binding surface; other site
742013014804	active site
742013014805	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
742013014806	putative binding surface; other site
742013014807	active site
742013014808	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
742013014809	putative binding surface; other site
742013014810	active site
742013014811	Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895
742013014812	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
742013014813	ATP binding site [chemical binding]; other site
742013014814	Mg2+ binding site [ion binding]; other site
742013014815	G-X-G motif; other site
742013014816	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256
742013014817	Response regulator receiver domain; Region: Response_reg; pfam00072
742013014818	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
742013014819	active site
742013014820	phosphorylation site [posttranslational modification]
742013014821	intermolecular recognition site; other site
742013014822	dimerization interface [polypeptide binding]; other site
742013014823	Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675
742013014824	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
742013014825	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
742013014826	dimer interface [polypeptide binding]; other site
742013014827	putative CheW interface [polypeptide binding]; other site
742013014828	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256
742013014829	Response regulator receiver domain; Region: Response_reg; pfam00072
742013014830	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
742013014831	active site
742013014832	phosphorylation site [posttranslational modification]
742013014833	intermolecular recognition site; other site
742013014834	dimerization interface [polypeptide binding]; other site
742013014835	Response regulator receiver domain; Region: Response_reg; pfam00072
742013014836	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
742013014837	active site
742013014838	phosphorylation site [posttranslational modification]
742013014839	intermolecular recognition site; other site
742013014840	dimerization interface [polypeptide binding]; other site
742013014841	Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730
742013014842	Rubredoxin; Region: Rubredoxin; pfam00301
742013014843	iron binding site [ion binding]; other site
742013014844	ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192
742013014845	substrate binding site [chemical binding]; other site
742013014846	ATP binding site [chemical binding]; other site
742013014847	glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062
742013014848	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
742013014849	inhibitor-cofactor binding pocket; inhibition site
742013014850	pyridoxal 5'-phosphate binding site [chemical binding]; other site
742013014851	catalytic residue [active]
742013014852	Methyladenine glycosylase; Region: Adenine_glyco; pfam03352
742013014853	Cytochrome c; Region: Cytochrom_C; cl11414
742013014854	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881
742013014855	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates...; Region: IMPCH; cd01421
742013014856	purine monophosphate binding site [chemical binding]; other site
742013014857	dimer interface [polypeptide binding]; other site
742013014858	putative catalytic residues [active]
742013014859	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798
742013014860	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362
742013014861	Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420
742013014862	putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737
742013014863	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
742013014864	FMN binding site [chemical binding]; other site
742013014865	active site
742013014866	catalytic residues [active]
742013014867	substrate binding site [chemical binding]; other site
742013014868	Predicted membrane protein [Function unknown]; Region: COG1238
742013014869	Transcriptional regulator [Transcription]; Region: LysR; COG0583
742013014870	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
742013014871	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
742013014872	putative effector binding pocket; other site
742013014873	dimerization interface [polypeptide binding]; other site
742013014874	Pirin-related protein [General function prediction only]; Region: COG1741
742013014875	Pirin; Region: Pirin; pfam02678
742013014876	YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012
742013014877	Isochorismatase family; Region: Isochorismatase; pfam00857
742013014878	catalytic triad [active]
742013014879	dimer interface [polypeptide binding]; other site
742013014880	conserved cis-peptide bond; other site
742013014881	Protein of unknown function (DUF1427); Region: DUF1427; pfam07235
742013014882	Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574
742013014883	YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300
742013014884	active site
742013014885	Transmembrane secretion effector; Region: MFS_3; pfam05977
742013014886	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
742013014887	Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566
742013014888	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
742013014889	active site
742013014890	phosphorylation site [posttranslational modification]
742013014891	intermolecular recognition site; other site
742013014892	dimerization interface [polypeptide binding]; other site
742013014893	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
742013014894	DNA binding residues [nucleotide binding]
742013014895	dimerization interface [polypeptide binding]; other site
742013014896	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
742013014897	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
742013014898	dimer interface [polypeptide binding]; other site
742013014899	phosphorylation site [posttranslational modification]
742013014900	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
742013014901	ATP binding site [chemical binding]; other site
742013014902	Mg2+ binding site [ion binding]; other site
742013014903	G-X-G motif; other site
742013014904	Outer membrane efflux protein; Region: OEP; pfam02321
742013014905	Outer membrane efflux protein; Region: OEP; pfam02321
742013014906	Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696
742013014907	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
742013014908	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
742013014909	HlyD family secretion protein; Region: HlyD_3; pfam13437
742013014910	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181
742013014911	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
742013014912	2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522
742013014913	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
742013014914	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
742013014915	benzoylformate decarboxylase; Reviewed; Region: PRK07092
742013014916	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
742013014917	PYR/PP interface [polypeptide binding]; other site
742013014918	dimer interface [polypeptide binding]; other site
742013014919	TPP binding site [chemical binding]; other site
742013014920	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
742013014921	Thiamine pyrophosphate (TPP) family, BFDC subfamily, TPP-binding module; composed of proteins similar to Pseudomonas putida benzoylformate decarboxylase (BFDC). P. putida BFDC plays a role in the mandelate pathway, catalyzing the conversion of...; Region: TPP_BFDC; cd02002
742013014922	TPP-binding site [chemical binding]; other site
742013014923	dimer interface [polypeptide binding]; other site
742013014924	Transcriptional regulator [Transcription]; Region: LysR; COG0583
742013014925	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
742013014926	The C-terminal substrate binding domain of LysR-type transcriptional regulators that are involved in the catabolism of dinitrotoluene, naphthalene and gamma-hexachlorohexane; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_NahR_LinR_like; cd08459
742013014927	substrate binding pocket [chemical binding]; other site
742013014928	dimerization interface [polypeptide binding]; other site
742013014929	3-hydroxybutyrate dehydrogenase; Provisional; Region: PRK12429
742013014930	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
742013014931	NAD(P) binding site [chemical binding]; other site
742013014932	active site
742013014933	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
742013014934	nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK06106
742013014935	Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572
742013014936	dimerization interface [polypeptide binding]; other site
742013014937	active site
742013014938	Uncharacterized conserved protein [General function prediction only]; Region: COG4111
742013014939	SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346
742013014940	Uncharacterized protein family (UPF0167); Region: UPF0167; cl01252
742013014941	GTP-binding protein YchF; Reviewed; Region: PRK09601
742013014942	YchF GTPase; Region: YchF; cd01900
742013014943	G1 box; other site
742013014944	GTP/Mg2+ binding site [chemical binding]; other site
742013014945	Switch I region; other site
742013014946	G2 box; other site
742013014947	Switch II region; other site
742013014948	G3 box; other site
742013014949	G4 box; other site
742013014950	G5 box; other site
742013014951	TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
742013014952	MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476
742013014953	Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217
742013014954	MOSC domain; Region: MOSC; pfam03473
742013014955	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
742013014956	2-polyprenyl-6-methoxyphenol 4-hydroxylase; Region: UbiH; TIGR01984
742013014957	protein disulfide isomerase II DsbC; Provisional; Region: PRK10877
742013014958	DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020
742013014959	dimerization domain [polypeptide binding]; other site
742013014960	dimer interface [polypeptide binding]; other site
742013014961	catalytic residues [active]
742013014962	Predicted protease with the C-terminal PDZ domain [General function prediction only]; Region: COG3975
742013014963	M61 glycyl aminopeptidase; Region: Peptidase_M61; pfam05299
742013014964	Domain present in PSD-95, Dlg, and ZO-1/2; Region: PDZ; smart00228
742013014965	protein binding site [polypeptide binding]; other site
742013014966	enoyl-CoA hydratase; Provisional; Region: PRK05862
742013014967	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
742013014968	substrate binding site [chemical binding]; other site
742013014969	oxyanion hole (OAH) forming residues; other site
742013014970	trimer interface [polypeptide binding]; other site
742013014971	Protein of unknown function (DUF1513); Region: DUF1513; pfam07433
742013014972	Imelysin; Region: Peptidase_M75; cl09159
742013014973	Predicted thiol oxidoreductase [Energy production and conversion]; Region: COG3488
742013014974	Protein of unknown function (DUF1111); Region: DUF1111; pfam06537
742013014975	Imelysin; Region: Peptidase_M75; cl09159
742013014976	Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion transport and metabolism]; Region: FhuE; COG4773
742013014977	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
742013014978	N-terminal plug; other site
742013014979	ligand-binding site [chemical binding]; other site
742013014980	benzoate transport; Region: 2A0115; TIGR00895
742013014981	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
742013014982	putative substrate translocation pore; other site
742013014983	N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; cl17549
742013014984	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
742013014985	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
742013014986	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
742013014987	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
742013014988	dimer interface [polypeptide binding]; other site
742013014989	conserved gate region; other site
742013014990	putative PBP binding loops; other site
742013014991	ABC-ATPase subunit interface; other site
742013014992	molybdenum ABC transporter, ATP-binding protein; Region: modC_ABC; TIGR02142
742013014993	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
742013014994	Walker A/P-loop; other site
742013014995	ATP binding site [chemical binding]; other site
742013014996	Q-loop/lid; other site
742013014997	ABC transporter signature motif; other site
742013014998	Walker B; other site
742013014999	D-loop; other site
742013015000	H-loop/switch region; other site
742013015001	TOBE domain; Region: TOBE; pfam03459
742013015002	FdhD/NarQ family; Region: FdhD-NarQ; cl00659
742013015003	(dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325
742013015004	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
742013015005	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
742013015006	FeS/SAM binding site; other site
742013015007	TRAM domain; Region: TRAM; pfam01938
742013015008	PcfJ-like protein; Region: PcfJ; pfam14284
742013015009	Protein of unknown function (DUF1266); Region: DUF1266; pfam06889
742013015010	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
742013015011	sequence-specific DNA binding site [nucleotide binding]; other site
742013015012	salt bridge; other site
742013015013	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
742013015014	NlpC/P60 family; Region: NLPC_P60; pfam00877
742013015015	signal recognition particle protein; Provisional; Region: PRK10867
742013015016	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
742013015017	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
742013015018	GTP binding site [chemical binding]; other site
742013015019	Signal peptide binding domain; Region: SRP_SPB; pfam02978
742013015020	PAS domain S-box; Region: sensory_box; TIGR00229
742013015021	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
742013015022	putative active site [active]
742013015023	heme pocket [chemical binding]; other site
742013015024	PAS fold; Region: PAS_4; pfam08448
742013015025	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
742013015026	putative active site [active]
742013015027	heme pocket [chemical binding]; other site
742013015028	PAS fold; Region: PAS_3; pfam08447
742013015029	PAS domain; Region: PAS_9; pfam13426
742013015030	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
742013015031	putative active site [active]
742013015032	heme pocket [chemical binding]; other site
742013015033	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
742013015034	dimer interface [polypeptide binding]; other site
742013015035	phosphorylation site [posttranslational modification]
742013015036	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
742013015037	ATP binding site [chemical binding]; other site
742013015038	Mg2+ binding site [ion binding]; other site
742013015039	G-X-G motif; other site
742013015040	Response regulator receiver domain; Region: Response_reg; pfam00072
742013015041	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
742013015042	active site
742013015043	phosphorylation site [posttranslational modification]
742013015044	intermolecular recognition site; other site
742013015045	dimerization interface [polypeptide binding]; other site
742013015046	Response regulator receiver domain; Region: Response_reg; pfam00072
742013015047	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
742013015048	active site
742013015049	phosphorylation site [posttranslational modification]
742013015050	intermolecular recognition site; other site
742013015051	dimerization interface [polypeptide binding]; other site
742013015052	Response regulator receiver domain; Region: Response_reg; pfam00072
742013015053	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
742013015054	active site
742013015055	phosphorylation site [posttranslational modification]
742013015056	intermolecular recognition site; other site
742013015057	dimerization interface [polypeptide binding]; other site
742013015058	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
742013015059	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
742013015060	metal binding site [ion binding]; metal-binding site
742013015061	active site
742013015062	I-site; other site
742013015063	Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504
742013015064	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
742013015065	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
742013015066	dimer interface [polypeptide binding]; other site
742013015067	phosphorylation site [posttranslational modification]
742013015068	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
742013015069	ATP binding site [chemical binding]; other site
742013015070	Mg2+ binding site [ion binding]; other site
742013015071	G-X-G motif; other site
742013015072	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
742013015073	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
742013015074	active site
742013015075	phosphorylation site [posttranslational modification]
742013015076	intermolecular recognition site; other site
742013015077	dimerization interface [polypeptide binding]; other site
742013015078	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
742013015079	Walker A motif; other site
742013015080	ATP binding site [chemical binding]; other site
742013015081	Walker B motif; other site
742013015082	arginine finger; other site
742013015083	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
742013015084	N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023
742013015085	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
742013015086	amidase catalytic site [active]
742013015087	Zn binding residues [ion binding]; other site
742013015088	substrate binding site [chemical binding]; other site
742013015089	ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07207
742013015090	ATP cone domain; Region: ATP-cone; pfam03477
742013015091	ATP cone domain; Region: ATP-cone; pfam03477
742013015092	Class I ribonucleotide reductase; Region: RNR_I; cd01679
742013015093	active site
742013015094	dimer interface [polypeptide binding]; other site
742013015095	catalytic residues [active]
742013015096	effector binding site; other site
742013015097	R2 peptide binding site; other site
742013015098	Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049
742013015099	dimer interface [polypeptide binding]; other site
742013015100	putative radical transfer pathway; other site
742013015101	diiron center [ion binding]; other site
742013015102	tyrosyl radical; other site
742013015103	Ribokinase-like subgroup A.  Found in bacteria and archaea, this subgroup is part of the ribokinase/pfkB superfamily.  Its oligomerization state is unknown at this time; Region: ribokinase_group_A; cd01942
742013015104	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
742013015105	substrate binding site [chemical binding]; other site
742013015106	ATP binding site [chemical binding]; other site
742013015107	zinc-ribbon domain; Region: zinc_ribbon_5; pfam13719
742013015108	Protein of unknown function (DUF3426); Region: DUF3426; pfam11906
742013015109	ribosomal protein L11 methyltransferase; Reviewed; Region: prmA; PRK00517
742013015110	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
742013015111	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
742013015112	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
742013015113	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
742013015114	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
742013015115	acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302
742013015116	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
742013015117	carboxyltransferase (CT) interaction site; other site
742013015118	biotinylation site [posttranslational modification]; other site
742013015119	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
742013015120	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
742013015121	catalytic residues [active]
742013015122	UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Region: mpl; TIGR01081
742013015123	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
742013015124	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
742013015125	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
742013015126	tRNA pseudouridine synthase C; Region: DUF446; pfam04287
742013015127	phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261
742013015128	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
742013015129	protease TldD; Provisional; Region: tldD; PRK10735
742013015130	rod shape-determining protein RodA; Region: rodA_shape; TIGR02210
742013015131	Uncharacterized protein family (UPF0227); Region: UPF0227; cl14886
742013015132	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
742013015133	This domain is the catalytic domain of ribonuclease II; Region: RNB; smart00955
742013015134	RNB domain; Region: RNB; pfam00773
742013015135	TonB C terminal; Region: TonB_2; pfam13103
742013015136	shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258
742013015137	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
742013015138	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
742013015139	shikimate binding site; other site
742013015140	NAD(P) binding site [chemical binding]; other site
742013015141	Transglycosylase; Region: Transgly; cl17702
742013015142	Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529
742013015143	active site
742013015144	putative DNA-binding cleft [nucleotide binding]; other site
742013015145	dimer interface [polypeptide binding]; other site
742013015146	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186
742013015147	UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331
742013015148	cell division protein FtsZ; Validated; Region: PRK09330
742013015149	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
742013015150	nucleotide binding site [chemical binding]; other site
742013015151	SulA interaction site; other site
742013015152	cell division protein FtsA; Region: ftsA; TIGR01174
742013015153	Cell division protein FtsA; Region: FtsA; smart00842
742013015154	Cell division protein FtsA; Region: FtsA; pfam14450
742013015155	POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478
742013015156	Cell division protein FtsQ; Region: FtsQ; pfam03799
742013015157	D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372
742013015158	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
742013015159	ATP-grasp domain; Region: ATP-grasp_4; cl17255
742013015160	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
742013015161	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
742013015162	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
742013015163	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
742013015164	undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726
742013015165	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
742013015166	active site
742013015167	homodimer interface [polypeptide binding]; other site
742013015168	cell division protein FtsW; Region: ftsW; TIGR02614
742013015169	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02006
742013015170	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
742013015171	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
742013015172	phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108
742013015173	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
742013015174	Mg++ binding site [ion binding]; other site
742013015175	putative catalytic motif [active]
742013015176	putative substrate binding site [chemical binding]; other site
742013015177	UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770
742013015178	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
742013015179	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
742013015180	UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139
742013015181	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
742013015182	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
742013015183	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
742013015184	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
742013015185	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
742013015186	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
742013015187	Cell division protein FtsL; Region: FtsL; pfam04999
742013015188	16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050
742013015189	MraW methylase family; Region: Methyltransf_5; cl17771
742013015190	cell division protein MraZ; Reviewed; Region: PRK00326
742013015191	MraZ protein; Region: MraZ; pfam02381
742013015192	MraZ protein; Region: MraZ; pfam02381
742013015193	ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201
742013015194	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
742013015195	Walker A motif; other site
742013015196	ATP binding site [chemical binding]; other site
742013015197	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
742013015198	Walker B motif; other site
742013015199	arginine finger; other site
742013015200	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
742013015201	Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913
742013015202	active site
742013015203	HslU subunit interaction site [polypeptide binding]; other site
742013015204	STAS domain; Region: STAS_2; pfam13466
742013015205	RNA polymerase-binding protein DksA; Region: dksA; TIGR02420
742013015206	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
742013015207	The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112
742013015208	P-loop, Walker A motif; other site
742013015209	Base recognition motif; other site
742013015210	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683
742013015211	site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236
742013015212	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
742013015213	active site
742013015214	DNA binding site [nucleotide binding]
742013015215	Int/Topo IB signature motif; other site
742013015216	Protein of unknown function, DUF484; Region: DUF484; cl17449
742013015217	diaminopimelate epimerase; Provisional; Region: dapF; PRK00450
742013015218	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
742013015219	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
742013015220	NUDIX domain; Region: NUDIX; pfam00293
742013015221	nudix motif; other site
742013015222	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
742013015223	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
742013015224	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
742013015225	RNA binding surface [nucleotide binding]; other site
742013015226	Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130
742013015227	active site
742013015228	RNA polymerase sigma factor; Reviewed; Region: PRK12527
742013015229	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
742013015230	DNA binding residues [nucleotide binding]
742013015231	Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712
742013015232	FecR protein; Region: FecR; pfam04773
742013015233	Secretin and TonB N terminus short domain; Region: STN; smart00965
742013015234	Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion transport and metabolism]; Region: FhuE; COG4773
742013015235	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
742013015236	N-terminal plug; other site
742013015237	ligand-binding site [chemical binding]; other site
742013015238	Helix-turn-helix domain; Region: HTH_18; pfam12833
742013015239	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
742013015240	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
742013015241	EamA-like transporter family; Region: EamA; pfam00892
742013015242	EamA-like transporter family; Region: EamA; pfam00892
742013015243	4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332
742013015244	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
742013015245	putative substrate translocation pore; other site
742013015246	Protein of unknown function (DUF2848); Region: DUF2848; pfam11010
742013015247	amidase; Provisional; Region: PRK07056
742013015248	Amidase; Region: Amidase; cl11426
742013015249	Transcriptional regulator [Transcription]; Region: LysR; COG0583
742013015250	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
742013015251	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
742013015252	dimerization interface [polypeptide binding]; other site
742013015253	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
742013015254	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
742013015255	dimer interface [polypeptide binding]; other site
742013015256	pyridoxal 5'-phosphate binding site [chemical binding]; other site
742013015257	catalytic residue [active]
742013015258	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
742013015259	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
742013015260	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
742013015261	Walker A/P-loop; other site
742013015262	ATP binding site [chemical binding]; other site
742013015263	Q-loop/lid; other site
742013015264	ABC transporter signature motif; other site
742013015265	Walker B; other site
742013015266	D-loop; other site
742013015267	H-loop/switch region; other site
742013015268	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
742013015269	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
742013015270	DNA-binding site [nucleotide binding]; DNA binding site
742013015271	UTRA domain; Region: UTRA; pfam07702
742013015272	prokaryotic 3-carboxy-cis,cis-muconate cycloisomerase (CMLE)_like; Region: pCLME; cd01597
742013015273	Adenylosuccinate lyase [Nucleotide transport and metabolism]; Region: PurB; COG0015
742013015274	tetramer interface [polypeptide binding]; other site
742013015275	active site
742013015276	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
742013015277	fumarate hydratase; Reviewed; Region: fumC; PRK00485
742013015278	Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013
742013015279	tetramer interface [polypeptide binding]; other site
742013015280	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181
742013015281	Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405
742013015282	Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019
742013015283	Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509
742013015284	Uncharacterized member of the PurR regulon [General function prediction only]; Region: yhhQ; COG1738
742013015285	M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like2; cd05667
742013015286	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
742013015287	metal binding site [ion binding]; metal-binding site
742013015288	putative dimer interface [polypeptide binding]; other site
742013015289	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
742013015290	conserved cys residue [active]
742013015291	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
742013015292	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
742013015293	Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016
742013015294	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
742013015295	Putative glycerate dehydrogenase and related proteins of the D-specific 2-hydroxy dehydrogenase family; Region: GDH_like_2; cd12164
742013015296	bifunctional glyoxylate/hydroxypyruvate reductase A; Provisional; Region: ghrA; PRK15469
742013015297	putative ligand binding site [chemical binding]; other site
742013015298	NAD binding site [chemical binding]; other site
742013015299	dimerization interface [polypeptide binding]; other site
742013015300	catalytic site [active]
742013015301	aldolase II superfamily protein; Provisional; Region: PRK07044
742013015302	intersubunit interface [polypeptide binding]; other site
742013015303	active site
742013015304	Zn2+ binding site [ion binding]; other site
742013015305	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
742013015306	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
742013015307	Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929
742013015308	acyl-activating enzyme (AAE) consensus motif; other site
742013015309	acyl-activating enzyme (AAE) consensus motif; other site
742013015310	putative AMP binding site [chemical binding]; other site
742013015311	putative active site [active]
742013015312	putative CoA binding site [chemical binding]; other site
742013015313	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
742013015314	Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025
742013015315	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715
742013015316	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
742013015317	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
742013015318	Ligand binding site [chemical binding]; other site
742013015319	Electron transfer flavoprotein domain; Region: ETF; pfam01012
742013015320	Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070
742013015321	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
742013015322	FMN binding site [chemical binding]; other site
742013015323	substrate binding site [chemical binding]; other site
742013015324	putative catalytic residue [active]
742013015325	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
742013015326	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
742013015327	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
742013015328	CoA-transferase family III; Region: CoA_transf_3; pfam02515
742013015329	enoyl-CoA hydratase; Provisional; Region: PRK07511
742013015330	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
742013015331	substrate binding site [chemical binding]; other site
742013015332	oxyanion hole (OAH) forming residues; other site
742013015333	trimer interface [polypeptide binding]; other site
742013015334	pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203
742013015335	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
742013015336	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
742013015337	active site
742013015338	pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204
742013015339	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
742013015340	active site
742013015341	acetyl-CoA acetyltransferase; Provisional; Region: PRK07108
742013015342	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
742013015343	dimer interface [polypeptide binding]; other site
742013015344	active site
742013015345	multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154
742013015346	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
742013015347	substrate binding site [chemical binding]; other site
742013015348	oxyanion hole (OAH) forming residues; other site
742013015349	trimer interface [polypeptide binding]; other site
742013015350	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
742013015351	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
742013015352	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
742013015353	Transcriptional regulator [Transcription]; Region: LysR; COG0583
742013015354	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
742013015355	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
742013015356	putative effector binding pocket; other site
742013015357	dimerization interface [polypeptide binding]; other site
742013015358	heat shock protein HtpX; Provisional; Region: PRK05457
742013015359	Protein of unknown function (DUF3025); Region: DUF3025; pfam11227
742013015360	Uncharacterized conserved protein [Function unknown]; Region: COG1432
742013015361	Uncharacterized subfamily of N-terminal LabA-like domains; Region: LabA_like_N_1; cd11297
742013015362	putative metal binding site [ion binding]; other site
742013015363	C-terminal domain of LabA_like proteins; Region: LabA_like_C; cd10146
742013015364	Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294
742013015365	active site
742013015366	substrate binding pocket [chemical binding]; other site
742013015367	dimer interface [polypeptide binding]; other site
742013015368	Isopentenyl diphosphate isomerase (BS_ypgA, MTH48 and related proteins) [Coenzyme transport and metabolism]; Region: idi; COG1304
742013015369	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
742013015370	phosphate binding site [ion binding]; other site
742013015371	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
742013015372	hypothetical protein; Validated; Region: PRK06201
742013015373	Demethylmenaquinone methyltransferase [Coenzyme metabolism]; Region: MenG; COG0684
742013015374	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
742013015375	Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173
742013015376	ligand binding site [chemical binding]; other site
742013015377	NAD binding site [chemical binding]; other site
742013015378	dimerization interface [polypeptide binding]; other site
742013015379	catalytic site [active]
742013015380	Transcriptional regulator [Transcription]; Region: LysR; COG0583
742013015381	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
742013015382	The C-terminal substrate binding domain of galactose-binding protein regulator contains the type 2 periplasmic binding fold; Region: PBP2_GbpR; cd08435
742013015383	putative dimerization interface [polypeptide binding]; other site
742013015384	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
742013015385	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
742013015386	ligand binding site [chemical binding]; other site
742013015387	flexible hinge region; other site
742013015388	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320
742013015389	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
742013015390	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
742013015391	trimer interface [polypeptide binding]; other site
742013015392	eyelet of channel; other site
742013015393	Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042
742013015394	CoA binding domain; Region: CoA_binding_2; pfam13380
742013015395	Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607
742013015396	ATP-grasp domain; Region: ATP-grasp_5; pfam13549
742013015397	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
742013015398	Uncharacterized conserved protein [Function unknown]; Region: COG5361
742013015399	Protein of unknown function (DUF1254); Region: DUF1254; pfam06863
742013015400	Protein of unknown function (DUF1214); Region: DUF1214; cl08447
742013015401	Uncharacterized conserved protein [Function unknown]; Region: COG5361
742013015402	Protein of unknown function (DUF1254); Region: DUF1254; pfam06863
742013015403	Protein of unknown function (DUF1214); Region: DUF1214; cl08447
742013015404	Alkyl sulfatase and related hydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2015
742013015405	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
742013015406	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181
742013015407	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
742013015408	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
742013015409	hypothetical protein; Provisional; Region: PRK07338
742013015410	M20 Peptidase Glutamate carboxypeptidase, a periplasmic enzyme; Region: M20_CPDG2; cd03885
742013015411	metal binding site [ion binding]; metal-binding site
742013015412	dimer interface [polypeptide binding]; other site
742013015413	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
742013015414	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
742013015415	putative active site [active]
742013015416	Secretin and TonB N terminus short domain; Region: STN; smart00965
742013015417	ferrichrome outer membrane transporter; Provisional; Region: PRK10044
742013015418	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
742013015419	N-terminal plug; other site
742013015420	ligand-binding site [chemical binding]; other site
742013015421	Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712
742013015422	FecR protein; Region: FecR; pfam04773
742013015423	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
742013015424	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
742013015425	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
742013015426	DNA binding residues [nucleotide binding]
742013015427	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
742013015428	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
742013015429	Walker A/P-loop; other site
742013015430	ATP binding site [chemical binding]; other site
742013015431	Q-loop/lid; other site
742013015432	ABC transporter signature motif; other site
742013015433	Walker B; other site
742013015434	D-loop; other site
742013015435	H-loop/switch region; other site
742013015436	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
742013015437	dimer interface [polypeptide binding]; other site
742013015438	conserved gate region; other site
742013015439	putative PBP binding loops; other site
742013015440	ABC-ATPase subunit interface; other site
742013015441	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
742013015442	dimer interface [polypeptide binding]; other site
742013015443	conserved gate region; other site
742013015444	putative PBP binding loops; other site
742013015445	ABC-ATPase subunit interface; other site
742013015446	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
742013015447	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
742013015448	substrate binding pocket [chemical binding]; other site
742013015449	membrane-bound complex binding site; other site
742013015450	hinge residues; other site
742013015451	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
742013015452	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
742013015453	dimerization interface [polypeptide binding]; other site
742013015454	Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290
742013015455	DctM-like transporters; Region: DctM; pfam06808
742013015456	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593
742013015457	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
742013015458	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480
742013015459	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
742013015460	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
742013015461	Hydroxy(phenyl)pyruvate Reductase, D-isomer-specific 2-hydroxyacid-related dehydrogenase; Region: HPPR; cd12156
742013015462	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
742013015463	putative ligand binding site [chemical binding]; other site
742013015464	NAD binding site [chemical binding]; other site
742013015465	catalytic site [active]
742013015466	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
742013015467	Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal  ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185
742013015468	FMN-binding pocket [chemical binding]; other site
742013015469	flavin binding motif; other site
742013015470	phosphate binding motif [ion binding]; other site
742013015471	beta-alpha-beta structure motif; other site
742013015472	NAD binding pocket [chemical binding]; other site
742013015473	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
742013015474	catalytic loop [active]
742013015475	iron binding site [ion binding]; other site
742013015476	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
742013015477	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
742013015478	iron-sulfur cluster [ion binding]; other site
742013015479	[2Fe-2S] cluster binding site [ion binding]; other site
742013015480	C-terminal catalytic domain of the oxygenase alpha subunit of dicamba O-demethylase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_DMO-like; cd08878
742013015481	alpha subunit interface [polypeptide binding]; other site
742013015482	active site
742013015483	substrate binding site [chemical binding]; other site
742013015484	Fe binding site [ion binding]; other site
742013015485	benzoate transport; Region: 2A0115; TIGR00895
742013015486	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
742013015487	putative substrate translocation pore; other site
742013015488	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
742013015489	MarR family; Region: MarR; pfam01047
742013015490	MarR family; Region: MarR_2; cl17246
742013015491	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
742013015492	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
742013015493	iron-sulfur cluster [ion binding]; other site
742013015494	[2Fe-2S] cluster binding site [ion binding]; other site
742013015495	C-terminal catalytic domain of the oxygenase alpha subunit of dicamba O-demethylase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_DMO-like; cd08878
742013015496	alpha subunit interface [polypeptide binding]; other site
742013015497	active site
742013015498	substrate binding site [chemical binding]; other site
742013015499	Fe binding site [ion binding]; other site
742013015500	phosphonate utilization associated transcriptional regulator; Region: phnR_burk; TIGR03338
742013015501	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
742013015502	DNA-binding site [nucleotide binding]; DNA binding site
742013015503	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
742013015504	Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412
742013015505	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
742013015506	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
742013015507	ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265
742013015508	ATP-binding cassette domain of iron-sulfur clusters transporter, subfamily C; Region: ABCC_ATM1_transporter; cd03253
742013015509	Walker A/P-loop; other site
742013015510	ATP binding site [chemical binding]; other site
742013015511	Q-loop/lid; other site
742013015512	ABC transporter signature motif; other site
742013015513	Walker B; other site
742013015514	D-loop; other site
742013015515	H-loop/switch region; other site
742013015516	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
742013015517	Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519
742013015518	Transcriptional regulators [Transcription]; Region: MarR; COG1846
742013015519	MarR family; Region: MarR; pfam01047
742013015520	Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_3; cd13148
742013015521	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
742013015522	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
742013015523	CoenzymeA binding site [chemical binding]; other site
742013015524	subunit interaction site [polypeptide binding]; other site
742013015525	PHB binding site; other site
742013015526	enoyl-CoA hydratase; Provisional; Region: PRK06688
742013015527	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
742013015528	substrate binding site [chemical binding]; other site
742013015529	oxyanion hole (OAH) forming residues; other site
742013015530	trimer interface [polypeptide binding]; other site
742013015531	Thioesterase-like superfamily; Region: 4HBT_3; pfam13622
742013015532	Predicted alpha/beta hydrolase [General function prediction only]; Region: COG4757
742013015533	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
742013015534	acetyl-CoA acetyltransferase; Provisional; Region: PRK09052
742013015535	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
742013015536	dimer interface [polypeptide binding]; other site
742013015537	active site
742013015538	3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250
742013015539	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
742013015540	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
742013015541	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
742013015542	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
742013015543	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
742013015544	substrate binding site [chemical binding]; other site
742013015545	oxyanion hole (OAH) forming residues; other site
742013015546	trimer interface [polypeptide binding]; other site
742013015547	Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; pfam09917
742013015548	Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418
742013015549	acyl-CoA dehydrogenase; Provisional; Region: PTZ00456
742013015550	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
742013015551	active site
742013015552	Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806
742013015553	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
742013015554	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
742013015555	Phage related hypothetical protein (DUF1799); Region: DUF1799; pfam08809
742013015556	Predicted transcriptional regulator [Transcription]; Region: COG2932
742013015557	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
742013015558	Catalytic site [active]
742013015559	division inhibitor protein; Provisional; Region: slmA; PRK09480
742013015560	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
742013015561	Two-component sensor kinase N-terminal; Region: 2CSK_N; pfam08521
742013015562	HAMP domain; Region: HAMP; pfam00672
742013015563	sensor protein QseC; Provisional; Region: PRK10337
742013015564	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
742013015565	phosphorylation site [posttranslational modification]
742013015566	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
742013015567	Mg2+ binding site [ion binding]; other site
742013015568	G-X-G motif; other site
742013015569	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
742013015570	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
742013015571	active site
742013015572	phosphorylation site [posttranslational modification]
742013015573	intermolecular recognition site; other site
742013015574	dimerization interface [polypeptide binding]; other site
742013015575	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
742013015576	DNA binding site [nucleotide binding]
742013015577	AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250
742013015578	feedback inhibition sensing region; other site
742013015579	homohexameric interface [polypeptide binding]; other site
742013015580	nucleotide binding site [chemical binding]; other site
742013015581	N-acetyl-L-glutamate binding site [chemical binding]; other site
742013015582	UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472
742013015583	This subfamily is composed of uncharacterized bacterial glycosyltransferases in the MraY-like family. This family contains both eukaryotic and prokaryotic UDP-D-N-acetylhexosamine:polyprenol phosphate D-N-acetylhexosamine-1-phosphate transferases, which...; Region: GT_MraY_like; cd06912
742013015584	Mg++ binding site [ion binding]; other site
742013015585	putative catalytic motif [active]
742013015586	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
742013015587	Methyltransferase domain; Region: Methyltransf_23; pfam13489
742013015588	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
742013015589	S-adenosylmethionine binding site [chemical binding]; other site
742013015590	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
742013015591	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
742013015592	Probable Catalytic site; other site
742013015593	metal-binding site
742013015594	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
742013015595	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
742013015596	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
742013015597	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
742013015598	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
742013015599	S-adenosylmethionine binding site [chemical binding]; other site
742013015600	ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134
742013015601	ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220
742013015602	Walker A/P-loop; other site
742013015603	ATP binding site [chemical binding]; other site
742013015604	Q-loop/lid; other site
742013015605	ABC transporter signature motif; other site
742013015606	Walker B; other site
742013015607	D-loop; other site
742013015608	H-loop/switch region; other site
742013015609	C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147
742013015610	putative carbohydrate binding site [chemical binding]; other site
742013015611	Acyltransferase family; Region: Acyl_transf_3; pfam01757
742013015612	Predicted O-acyltransferase [General function prediction only]; Region: COG3274
742013015613	ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682
742013015614	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
742013015615	PPIC-type PPIASE domain; Region: Rotamase_3; pfam13616
742013015616	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
742013015617	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
742013015618	pilus (MSHA type) biogenesis protein MshL; Region: pilus_MshL; TIGR02519
742013015619	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
742013015620	Type II secretion system (T2SS), protein M subtype b; Region: T2SM_b; pfam10741
742013015621	Fimbrial assembly protein (PilN); Region: PilN; pfam05137
742013015622	Helix-hairpin-helix motif; Region: HHH_3; pfam12836
742013015623	general secretion pathway protein J; Validated; Region: PRK08808
742013015624	type II secretion system protein I; Region: gspI; TIGR01707
742013015625	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830
742013015626	type II secretion system protein H; Region: typeII_sec_gspH; TIGR01708
742013015627	Type II transport protein GspH; Region: GspH; pfam12019
742013015628	Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334
742013015629	Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459
742013015630	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
742013015631	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
742013015632	Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157
742013015633	type II secretion system protein E; Region: type_II_gspE; TIGR02533
742013015634	PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129
742013015635	Walker A motif; other site
742013015636	ATP binding site [chemical binding]; other site
742013015637	Walker B motif; other site
742013015638	pantothenate kinase; Reviewed; Region: PRK13329
742013015639	LysM domain/BON superfamily protein; Provisional; Region: PRK11198
742013015640	BON domain; Region: BON; pfam04972
742013015641	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
742013015642	Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518
742013015643	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
742013015644	Transcriptional regulator [Transcription]; Region: LysR; COG0583
742013015645	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
742013015646	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
742013015647	dimerization interface [polypeptide binding]; other site
742013015648	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
742013015649	active site residue [active]
742013015650	Protein of unknown function DUF45; Region: DUF45; pfam01863
742013015651	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
742013015652	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
742013015653	putative acyl-acceptor binding pocket; other site
742013015654	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
742013015655	histidinol-phosphate phosphatase family domain; Region: Histidinol-ppas; TIGR01656
742013015656	active site
742013015657	motif I; other site
742013015658	motif II; other site
742013015659	HAD-hyrolase-like; Region: Hydrolase_like; pfam13242
742013015660	glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233
742013015661	Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733
742013015662	dimer interface [polypeptide binding]; other site
742013015663	motif 1; other site
742013015664	active site
742013015665	motif 2; other site
742013015666	motif 3; other site
742013015667	A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  Many of these band 7 domain-containing proteins are lipid raft-associated.  Individual...; Region: Band_7_5; cd03408
742013015668	Helix-turn-helix domain; Region: HTH_17; pfam12728
742013015669	zinc-ribbon domain; Region: zf-ribbon_3; pfam13248
742013015670	putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834
742013015671	FAD dependent oxidoreductase TIGR03364; Region: HpnW_proposed
742013015672	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
742013015673	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
742013015674	dimer interface [polypeptide binding]; other site
742013015675	conserved gate region; other site
742013015676	putative PBP binding loops; other site
742013015677	ABC-ATPase subunit interface; other site
742013015678	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
742013015679	dimer interface [polypeptide binding]; other site
742013015680	conserved gate region; other site
742013015681	putative PBP binding loops; other site
742013015682	ABC-ATPase subunit interface; other site
742013015683	ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839
742013015684	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
742013015685	Walker A/P-loop; other site
742013015686	ATP binding site [chemical binding]; other site
742013015687	Q-loop/lid; other site
742013015688	ABC transporter signature motif; other site
742013015689	Walker B; other site
742013015690	D-loop; other site
742013015691	H-loop/switch region; other site
742013015692	ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143
742013015693	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
742013015694	Transcriptional regulators [Transcription]; Region: GntR; COG1802
742013015695	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
742013015696	DNA-binding site [nucleotide binding]; DNA binding site
742013015697	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
742013015698	Cytosine/uracil/thiamine/allantoin permeases [Nucleotide transport and metabolism / Coenzyme metabolism]; Region: FUI1; COG1953
742013015699	Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133
742013015700	Na binding site [ion binding]; other site
742013015701	aminoethylphosphonate catabolism associated LysR family transcriptional regulator; Region: phn_lysR; TIGR03339
742013015702	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
742013015703	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
742013015704	dimerization interface [polypeptide binding]; other site
742013015705	dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908
742013015706	G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538
742013015707	glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207
742013015708	substrate binding site; other site
742013015709	tetramer interface; other site
742013015710	dTDP-4-dehydrorhamnose reductase; Provisional; Region: PRK09987
742013015711	dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254
742013015712	NADP binding site [chemical binding]; other site
742013015713	active site
742013015714	putative substrate binding site [chemical binding]; other site
742013015715	dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088
742013015716	dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246
742013015717	NAD binding site [chemical binding]; other site
742013015718	substrate binding site [chemical binding]; other site
742013015719	homodimer interface [polypeptide binding]; other site
742013015720	active site
742013015721	3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967
742013015722	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
742013015723	dimer interface [polypeptide binding]; other site
742013015724	active site
742013015725	FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287
742013015726	dimer interface [polypeptide binding]; other site
742013015727	active site 1 [active]
742013015728	active site 2 [active]
742013015729	apolipoprotein N-acyltransferase; Region: lnt; TIGR00546
742013015730	Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571
742013015731	putative active site [active]
742013015732	catalytic triad [active]
742013015733	putative dimer interface [polypeptide binding]; other site
742013015734	Putative Mg2+ and Co2+ transporter CorC [Inorganic ion transport and metabolism]; Region: CorC; COG4535
742013015735	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
742013015736	Transporter associated domain; Region: CorC_HlyC; smart01091
742013015737	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
742013015738	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
742013015739	Coenzyme A binding pocket [chemical binding]; other site
742013015740	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
742013015741	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
742013015742	dimerization interface [polypeptide binding]; other site
742013015743	putative DNA binding site [nucleotide binding]; other site
742013015744	putative Zn2+ binding site [ion binding]; other site
742013015745	AsnC family; Region: AsnC_trans_reg; pfam01037
742013015746	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
742013015747	Prokaryotic phenylalanine-4-hydroxylase (pro_PheOH); a member of the biopterin-dependent aromatic amino acid hydroxylase family of non-heme, iron(II)-dependent enzymes that also includes the eukaryotic proteins, phenylalanine-4-hydroxylase (eu_PheOH); Region: pro_PheOH; cd03348
742013015748	cofactor binding site; other site
742013015749	metal binding site [ion binding]; metal-binding site
742013015750	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
742013015751	PGAP1-like protein; Region: PGAP1; pfam07819
742013015752	Long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07059
742013015753	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
742013015754	Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936
742013015755	acyl-activating enzyme (AAE) consensus motif; other site
742013015756	putative AMP binding site [chemical binding]; other site
742013015757	putative active site [active]
742013015758	putative CoA binding site [chemical binding]; other site
742013015759	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
742013015760	catecholate siderophore receptor Fiu; Provisional; Region: PRK09840
742013015761	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
742013015762	N-terminal plug; other site
742013015763	ligand-binding site [chemical binding]; other site
742013015764	catecholate siderophore receptor Fiu; Provisional; Region: PRK09840
742013015765	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
742013015766	N-terminal plug; other site
742013015767	ligand-binding site [chemical binding]; other site
742013015768	Fe(II)-dependent oxygenase superfamily protein; Provisional; Region: PRK05467
742013015769	Domain of unknown function (DUF4124); Region: DUF4124; pfam13511
742013015770	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
742013015771	N-acetyl-D-glucosamine binding site [chemical binding]; other site
742013015772	catalytic residue [active]
742013015773	5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212; cl00360
742013015774	5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812
742013015775	ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995
742013015776	Ligand Binding Site [chemical binding]; other site
742013015777	GST_N family, unknown subfamily 1; composed of uncharacterized proteins, predominantly from bacteria, with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with...; Region: GST_N_1; cd03043
742013015778	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
742013015779	putative C-terminal domain interface [polypeptide binding]; other site
742013015780	putative GSH binding site (G-site) [chemical binding]; other site
742013015781	putative dimer interface [polypeptide binding]; other site
742013015782	C-terminal, alpha helical domain of an unknown subfamily 3 of Glutathione S-transferases; Region: GST_C_3; cd03194
742013015783	putative N-terminal domain interface [polypeptide binding]; other site
742013015784	putative dimer interface [polypeptide binding]; other site
742013015785	putative substrate binding pocket (H-site) [chemical binding]; other site
742013015786	hypothetical protein; Provisional; Region: PRK08201
742013015787	Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_1; cd05678
742013015788	putative metal binding site [ion binding]; other site
742013015789	putative dimer interface [polypeptide binding]; other site
742013015790	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
742013015791	multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase; Reviewed; Region: cca; PRK10885
742013015792	active site
742013015793	NTP binding site [chemical binding]; other site
742013015794	metal binding triad [ion binding]; metal-binding site
742013015795	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
742013015796	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
742013015797	Zn2+ binding site [ion binding]; other site
742013015798	Mg2+ binding site [ion binding]; other site
742013015799	7TMR-DISM extracellular 2; Region: 7TMR-DISMED2; pfam07696
742013015800	7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695
742013015801	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
742013015802	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
742013015803	dimer interface [polypeptide binding]; other site
742013015804	phosphorylation site [posttranslational modification]
742013015805	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
742013015806	ATP binding site [chemical binding]; other site
742013015807	G-X-G motif; other site
742013015808	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
742013015809	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
742013015810	active site
742013015811	phosphorylation site [posttranslational modification]
742013015812	intermolecular recognition site; other site
742013015813	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355
742013015814	DNA binding site [nucleotide binding]
742013015815	thioredoxin 2; Provisional; Region: PRK10996
742013015816	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
742013015817	catalytic residues [active]
742013015818	Protein of unknown function (DUF2905); Region: DUF2905; pfam11146
742013015819	Uncharacterized conserved protein [Function unknown]; Region: COG1565
742013015820	short chain dehydrogenase; Provisional; Region: PRK09134
742013015821	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
742013015822	NAD(P) binding site [chemical binding]; other site
742013015823	active site
742013015824	Dihydroneopterin aldolase; Region: FolB; smart00905
742013015825	active site
742013015826	tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696
742013015827	This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily  includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which  binds to Adenosine group.  This subfamily; Region: Alpha_ANH_like_II; cd01993
742013015828	Ligand Binding Site [chemical binding]; other site
742013015829	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
742013015830	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
742013015831	Walker A/P-loop; other site
742013015832	ATP binding site [chemical binding]; other site
742013015833	Q-loop/lid; other site
742013015834	ABC transporter signature motif; other site
742013015835	Walker B; other site
742013015836	D-loop; other site
742013015837	H-loop/switch region; other site
742013015838	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
742013015839	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
742013015840	Walker A/P-loop; other site
742013015841	ATP binding site [chemical binding]; other site
742013015842	Q-loop/lid; other site
742013015843	ABC transporter signature motif; other site
742013015844	Walker B; other site
742013015845	D-loop; other site
742013015846	H-loop/switch region; other site
742013015847	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
742013015848	glutathione ABC transporter permease GsiD; Provisional; Region: PRK15082
742013015849	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
742013015850	dimer interface [polypeptide binding]; other site
742013015851	conserved gate region; other site
742013015852	putative PBP binding loops; other site
742013015853	ABC-ATPase subunit interface; other site
742013015854	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
742013015855	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
742013015856	dimer interface [polypeptide binding]; other site
742013015857	conserved gate region; other site
742013015858	putative PBP binding loops; other site
742013015859	ABC-ATPase subunit interface; other site
742013015860	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
742013015861	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_2; cd08498
742013015862	hypothetical protein; Provisional; Region: PRK11667
742013015863	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
742013015864	catalytic core [active]
742013015865	Curli production assembly/transport component CsgG; Region: CsgG; cl17434
742013015866	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
742013015867	Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000
742013015868	Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116
742013015869	YhhN-like protein; Region: YhhN; pfam07947
742013015870	magnesium-transporting ATPase MgtA; Provisional; Region: PRK10517
742013015871	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690
742013015872	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
742013015873	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
742013015874	Soluble P-type ATPase [General function prediction only]; Region: COG4087
742013015875	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
742013015876	Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285
742013015877	MgtC family; Region: MgtC; pfam02308
742013015878	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
742013015879	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
742013015880	Walker A motif; other site
742013015881	ATP binding site [chemical binding]; other site
742013015882	Walker B motif; other site
742013015883	arginine finger; other site
742013015884	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
742013015885	Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116
742013015886	RuvA N terminal domain; Region: RuvA_N; pfam01330
742013015887	Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702
742013015888	PhoH-like protein; Region: PhoH; pfam02562
742013015889	Uncharacterized protein family UPF0054; Region: UPF0054; cl00402
742013015890	Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288
742013015891	putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823
742013015892	NADP binding site [chemical binding]; other site
742013015893	dimer interface [polypeptide binding]; other site
742013015894	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
742013015895	CoA-transferase family III; Region: CoA_transf_3; pfam02515
742013015896	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
742013015897	Transcriptional regulator [Transcription]; Region: LysR; COG0583
742013015898	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
742013015899	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
742013015900	dimerization interface [polypeptide binding]; other site
742013015901	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
742013015902	Arc-like DNA binding domain; Region: Arc; pfam03869
742013015903	CRISPR/Cas system-associated RAMP superfamily protein Cas6f; Region: Cas6_I-F; cd09739
742013015904	CRISPR/Cas system-associated RAMP superfamily protein Csy3; Region: Csy3_I-F; cd09737
742013015905	CRISPR/Cas system-associated RAMP superfamily protein Csy2; Region: Csy2_I-F; cd09736
742013015906	CRISPR/Cas system-associated protein Csy1; Region: Csy1_I-F; cd09735
742013015907	Plasmid maintenance system killer protein; Region: Plasmid_killer; cl01422
742013015908	Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093
742013015909	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
742013015910	non-specific DNA binding site [nucleotide binding]; other site
742013015911	salt bridge; other site
742013015912	sequence-specific DNA binding site [nucleotide binding]; other site
742013015913	CRISPR/Cas system-associated protein Cas3/Cas2; Region: Cas3_Cas2_I-F; cd09673
742013015914	CRISPR-associated helicase Cas3, subtype I-F/YPEST; Region: cas3_yersinia; TIGR02562
742013015915	CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cl00656
742013015916	hypothetical protein; Provisional; Region: PRK06156
742013015917	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
742013015918	metal binding site [ion binding]; metal-binding site
742013015919	D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563
742013015920	putative active site [active]
742013015921	dimerization interface [polypeptide binding]; other site
742013015922	putative tRNAtyr binding site [nucleotide binding]; other site
742013015923	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
742013015924	Cation efflux family; Region: Cation_efflux; pfam01545
742013015925	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
742013015926	dimer interface [polypeptide binding]; other site
742013015927	phosphorylation site [posttranslational modification]
742013015928	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
742013015929	ATP binding site [chemical binding]; other site
742013015930	Mg2+ binding site [ion binding]; other site
742013015931	G-X-G motif; other site
742013015932	Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566
742013015933	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
742013015934	active site
742013015935	phosphorylation site [posttranslational modification]
742013015936	intermolecular recognition site; other site
742013015937	dimerization interface [polypeptide binding]; other site
742013015938	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
742013015939	DNA binding residues [nucleotide binding]
742013015940	dimerization interface [polypeptide binding]; other site
742013015941	Domain of unknown function (DUF336); Region: DUF336; cl01249
742013015942	PAS fold; Region: PAS_4; pfam08448
742013015943	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
742013015944	putative active site [active]
742013015945	heme pocket [chemical binding]; other site
742013015946	PAS domain S-box; Region: sensory_box; TIGR00229
742013015947	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
742013015948	putative active site [active]
742013015949	heme pocket [chemical binding]; other site
742013015950	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
742013015951	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
742013015952	metal binding site [ion binding]; metal-binding site
742013015953	active site
742013015954	I-site; other site
742013015955	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
742013015956	AMP nucleosidase; Provisional; Region: PRK08292
742013015957	Bacterial AMP nucleoside phosphorylase N-terminus; Region: AMNp_N; pfam10423
742013015958	Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775
742013015959	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
742013015960	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
742013015961	metal binding site [ion binding]; metal-binding site
742013015962	active site
742013015963	I-site; other site
742013015964	choline dehydrogenase; Validated; Region: PRK02106
742013015965	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
742013015966	3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808
742013015967	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
742013015968	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
742013015969	enoyl-CoA hydratase; Provisional; Region: PRK06563
742013015970	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
742013015971	substrate binding site [chemical binding]; other site
742013015972	oxyanion hole (OAH) forming residues; other site
742013015973	trimer interface [polypeptide binding]; other site
742013015974	Transcriptional regulators [Transcription]; Region: MarR; COG1846
742013015975	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
742013015976	putative Zn2+ binding site [ion binding]; other site
742013015977	putative DNA binding site [nucleotide binding]; other site
742013015978	peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561
742013015979	2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563
742013015980	serine/threonine protein kinase; Provisional; Region: PRK11768
742013015981	Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334
742013015982	Response regulator receiver domain; Region: Response_reg; pfam00072
742013015983	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
742013015984	active site
742013015985	phosphorylation site [posttranslational modification]
742013015986	intermolecular recognition site; other site
742013015987	dimerization interface [polypeptide binding]; other site
742013015988	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
742013015989	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
742013015990	metal binding site [ion binding]; metal-binding site
742013015991	active site
742013015992	I-site; other site
742013015993	Major Facilitator Superfamily; Region: MFS_1; pfam07690
742013015994	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
742013015995	putative substrate translocation pore; other site
742013015996	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
742013015997	redox-sensitive transcriptional activator SoxR; Region: SoxR; TIGR01950
742013015998	DNA binding residues [nucleotide binding]
742013015999	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
742013016000	homotrimer interaction site [polypeptide binding]; other site
742013016001	putative active site [active]
742013016002	UreD urease accessory protein; Region: UreD; pfam01774
742013016003	Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390
742013016004	alpha-gamma subunit interface [polypeptide binding]; other site
742013016005	beta-gamma subunit interface [polypeptide binding]; other site
742013016006	HupE / UreJ protein; Region: HupE_UreJ; pfam04955
742013016007	Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407
742013016008	gamma-beta subunit interface [polypeptide binding]; other site
742013016009	alpha-beta subunit interface [polypeptide binding]; other site
742013016010	urease subunit alpha; Reviewed; Region: ureC; PRK13207
742013016011	Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375
742013016012	subunit interactions [polypeptide binding]; other site
742013016013	active site
742013016014	flap region; other site
742013016015	urease accessory protein UreE; Provisional; Region: ureE; PRK13263
742013016016	UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571
742013016017	dimer interface [polypeptide binding]; other site
742013016018	catalytic residues [active]
742013016019	Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830
742013016020	UreF; Region: UreF; pfam01730
742013016021	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882
742013016022	G1 box; other site
742013016023	GTP/Mg2+ binding site [chemical binding]; other site
742013016024	G2 box; other site
742013016025	Switch I region; other site
742013016026	G3 box; other site
742013016027	Switch II region; other site
742013016028	G4 box; other site
742013016029	G5 box; other site
742013016030	Predicted membrane protein [Function unknown]; Region: COG4083; cl15694
742013016031	Domain of unknown function DUF11; Region: DUF11; pfam01345
742013016032	Domain of unknown function DUF11; Region: DUF11; cl17728
742013016033	Domain of unknown function DUF11; Region: DUF11; pfam01345
742013016034	heat shock protein 90; Provisional; Region: PRK05218
742013016035	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
742013016036	ATP binding site [chemical binding]; other site
742013016037	Mg2+ binding site [ion binding]; other site
742013016038	G-X-G motif; other site
742013016039	Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333
742013016040	amphipathic channel; other site
742013016041	Asn-Pro-Ala signature motifs; other site
742013016042	Outer membrane receptor for monomeric catechols [Inorganic ion transport and metabolism]; Region: Fiu; COG4774
742013016043	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
742013016044	N-terminal plug; other site
742013016045	ligand-binding site [chemical binding]; other site
742013016046	Fe(II)-dependent oxygenase superfamily protein; Provisional; Region: PRK05467
742013016047	Secretin and TonB N terminus short domain; Region: STN; smart00965
742013016048	Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion transport and metabolism]; Region: FhuE; COG4773
742013016049	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
742013016050	N-terminal plug; other site
742013016051	ligand-binding site [chemical binding]; other site
742013016052	fec operon regulator FecR; Reviewed; Region: PRK09774
742013016053	FecR protein; Region: FecR; pfam04773
742013016054	RNA polymerase sigma factor FecI; Provisional; Region: PRK09651
742013016055	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
742013016056	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
742013016057	DNA binding residues [nucleotide binding]
742013016058	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
742013016059	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
742013016060	RNA binding surface [nucleotide binding]; other site
742013016061	Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130
742013016062	active site
742013016063	Transcriptional regulator [Transcription]; Region: IclR; COG1414
742013016064	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
742013016065	Bacterial transcriptional regulator; Region: IclR; pfam01614
742013016066	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
742013016067	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
742013016068	active site
742013016069	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
742013016070	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
742013016071	CoA-transferase family III; Region: CoA_transf_3; pfam02515
742013016072	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
742013016073	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
742013016074	ligand binding site [chemical binding]; other site
742013016075	flexible hinge region; other site
742013016076	Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545
742013016077	non-specific DNA interactions [nucleotide binding]; other site
742013016078	DNA binding site [nucleotide binding]
742013016079	sequence specific DNA binding site [nucleotide binding]; other site
742013016080	putative cAMP binding site [chemical binding]; other site
742013016081	Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022
742013016082	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
742013016083	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
742013016084	Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907
742013016085	acyl-activating enzyme (AAE) consensus motif; other site
742013016086	acyl-activating enzyme (AAE) consensus motif; other site
742013016087	putative AMP binding site [chemical binding]; other site
742013016088	putative active site [active]
742013016089	putative CoA binding site [chemical binding]; other site
742013016090	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
742013016091	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
742013016092	Walker A/P-loop; other site
742013016093	ATP binding site [chemical binding]; other site
742013016094	Q-loop/lid; other site
742013016095	ABC transporter signature motif; other site
742013016096	Walker B; other site
742013016097	D-loop; other site
742013016098	H-loop/switch region; other site
742013016099	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
742013016100	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
742013016101	TM-ABC transporter signature motif; other site
742013016102	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
742013016103	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
742013016104	TM-ABC transporter signature motif; other site
742013016105	Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_1; cd06334
742013016106	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
742013016107	putative ligand binding site [chemical binding]; other site
742013016108	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
742013016109	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
742013016110	Walker A/P-loop; other site
742013016111	ATP binding site [chemical binding]; other site
742013016112	Q-loop/lid; other site
742013016113	ABC transporter signature motif; other site
742013016114	Walker B; other site
742013016115	D-loop; other site
742013016116	H-loop/switch region; other site
742013016117	Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541
742013016118	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
742013016119	acyl-activating enzyme (AAE) consensus motif; other site
742013016120	active site
742013016121	AMP binding site [chemical binding]; other site
742013016122	CoA binding site [chemical binding]; other site
742013016123	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
742013016124	Transcriptional regulator [Transcription]; Region: LysR; COG0583
742013016125	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
742013016126	LysR substrate binding domain; Region: LysR_substrate; pfam03466
742013016127	dimerization interface [polypeptide binding]; other site
742013016128	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
742013016129	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
742013016130	active site
742013016131	catalytic tetrad [active]
742013016132	Domain of unknown function (DUF1840); Region: DUF1840; pfam08895
742013016133	Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353
742013016134	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
742013016135	Predicted aminopeptidase (DUF2265); Region: DUF2265; pfam10023
742013016136	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
742013016137	dimer interface [polypeptide binding]; other site
742013016138	phosphorylation site [posttranslational modification]
742013016139	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
742013016140	ATP binding site [chemical binding]; other site
742013016141	Mg2+ binding site [ion binding]; other site
742013016142	G-X-G motif; other site
742013016143	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
742013016144	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
742013016145	active site
742013016146	phosphorylation site [posttranslational modification]
742013016147	intermolecular recognition site; other site
742013016148	dimerization interface [polypeptide binding]; other site
742013016149	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
742013016150	DNA binding site [nucleotide binding]
742013016151	Domain of unknown function (DUF1705); Region: DUF1705; pfam08019
742013016152	Sulfatase; Region: Sulfatase; pfam00884
742013016153	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
742013016154	nucleoside/Zn binding site; other site
742013016155	dimer interface [polypeptide binding]; other site
742013016156	catalytic motif [active]
742013016157	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
742013016158	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
742013016159	dimer interface [polypeptide binding]; other site
742013016160	conserved gate region; other site
742013016161	putative PBP binding loops; other site
742013016162	ABC-ATPase subunit interface; other site
742013016163	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
742013016164	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
742013016165	Walker A/P-loop; other site
742013016166	ATP binding site [chemical binding]; other site
742013016167	Q-loop/lid; other site
742013016168	ABC transporter signature motif; other site
742013016169	Walker B; other site
742013016170	D-loop; other site
742013016171	H-loop/switch region; other site
742013016172	NMT1/THI5 like; Region: NMT1; pfam09084
742013016173	TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122
742013016174	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
742013016175	nucleoside/Zn binding site; other site
742013016176	dimer interface [polypeptide binding]; other site
742013016177	catalytic motif [active]
742013016178	NMT1/THI5 like; Region: NMT1; pfam09084
742013016179	oxidase reductase; Provisional; Region: PTZ00273
742013016180	non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226
742013016181	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171
742013016182	Acyl CoA binding protein; Region: ACBP; pfam00887
742013016183	acyl-CoA binding pocket [chemical binding]; other site
742013016184	CoA binding site [chemical binding]; other site
742013016185	ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259
742013016186	Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884
742013016187	Walker A/P-loop; other site
742013016188	ATP binding site [chemical binding]; other site
742013016189	Q-loop/lid; other site
742013016190	ABC transporter signature motif; other site
742013016191	Walker B; other site
742013016192	D-loop; other site
742013016193	H-loop/switch region; other site
742013016194	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
742013016195	M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666
742013016196	metal binding site [ion binding]; metal-binding site
742013016197	putative dimer interface [polypeptide binding]; other site
742013016198	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
742013016199	Type I periplasmic binding domain of uncharacterized extracellular ligand-binding proteins; Region: PBP1_STKc_like; cd06326
742013016200	putative ligand binding site [chemical binding]; other site
742013016201	Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243
742013016202	The MopB_3 CD includes a group of related uncharacterized bacterial and archaeal molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members...; Region: MopB_3; cd02766
742013016203	putative [4Fe-4S] binding site [ion binding]; other site
742013016204	putative molybdopterin cofactor binding site [chemical binding]; other site
742013016205	The MopB_CT_3 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is of the...; Region: MopB_CT_3; cd02786
742013016206	putative molybdopterin cofactor binding site; other site
742013016207	2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982
742013016208	ABC1 family; Region: ABC1; cl17513
742013016209	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
742013016210	TraB family; Region: TraB; pfam01963
742013016211	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
742013016212	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
742013016213	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
742013016214	Transcriptional regulator [Transcription]; Region: IclR; COG1414
742013016215	Bacterial transcriptional regulator; Region: IclR; pfam01614
742013016216	Protein of unknown function (DUF3108); Region: DUF3108; pfam11306
742013016217	Protein of unknown function (DUF3567); Region: DUF3567; pfam12091
742013016218	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
742013016219	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
742013016220	Glycerol kinase [Energy production and conversion]; Region: GlpK; COG0554
742013016221	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
742013016222	nucleotide binding site [chemical binding]; other site
742013016223	Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578
742013016224	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
742013016225	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
742013016226	FAD binding domain; Region: FAD_binding_4; pfam01565
742013016227	Glycerol-3-phosphate responsive antiterminator; Region: G3P_antiterm; cl00852
742013016228	Putative ammonia monooxygenase [General function prediction only]; Region: AbrB; COG3180
742013016229	membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082
742013016230	membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082
742013016231	Hemerythrin-like domain; Region: Hr-like; cd12108
742013016232	Fe binding site [ion binding]; other site
742013016233	Ribonucleotide reductase, all-alpha domain; Region: Ribonuc_red_lgN; pfam00317
742013016234	Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939
742013016235	Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081
742013016236	protein-splicing catalytic site; other site
742013016237	thioester formation/cholesterol transfer; other site
742013016238	Hint (Hedgehog/Intein) domain C-terminal region; Region: HintC; smart00305
742013016239	Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939
742013016240	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884
742013016241	active site clefts [active]
742013016242	zinc binding site [ion binding]; other site
742013016243	dimer interface [polypeptide binding]; other site
742013016244	Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760
742013016245	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
742013016246	Nitrate reductase gamma subunit; Region: Nitrate_red_gam; pfam02665
742013016247	Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958
742013016248	Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140
742013016249	4Fe-4S binding domain; Region: Fer4; cl02805
742013016250	Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013
742013016251	Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750
742013016252	[4Fe-4S] binding site [ion binding]; other site
742013016253	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
742013016254	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
742013016255	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
742013016256	Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776
742013016257	molybdopterin cofactor binding site; other site
742013016258	nitrate/nitrite transport protein NarU; Provisional; Region: PRK15034
742013016259	Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223
742013016260	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
742013016261	putative substrate translocation pore; other site
742013016262	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
742013016263	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
742013016264	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
742013016265	N-terminal plug; other site
742013016266	ligand-binding site [chemical binding]; other site
742013016267	siderophore transporter, RhtX/FptX family; Region: sider_RhtX_FptX; TIGR02718
742013016268	transcriptional regulator NarL; Provisional; Region: PRK10651
742013016269	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
742013016270	active site
742013016271	phosphorylation site [posttranslational modification]
742013016272	intermolecular recognition site; other site
742013016273	dimerization interface [polypeptide binding]; other site
742013016274	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
742013016275	DNA binding residues [nucleotide binding]
742013016276	dimerization interface [polypeptide binding]; other site
742013016277	Signal transduction histidine kinase, nitrate/nitrite-specific [Signal transduction mechanisms]; Region: NarQ; COG3850
742013016278	Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675
742013016279	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
742013016280	dimerization interface [polypeptide binding]; other site
742013016281	GAF domain; Region: GAF; pfam01590
742013016282	Histidine kinase; Region: HisKA_3; pfam07730
742013016283	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
742013016284	ATP binding site [chemical binding]; other site
742013016285	Mg2+ binding site [ion binding]; other site
742013016286	G-X-G motif; other site
742013016287	Protein of unknown function, DUF399; Region: DUF399; pfam04187
742013016288	Protein of unknown function (DUF3297); Region: DUF3297; pfam11730
742013016289	Protein of unknown function (DUF445); Region: DUF445; pfam04286
742013016290	enterobactin receptor protein; Provisional; Region: PRK13483
742013016291	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
742013016292	N-terminal plug; other site
742013016293	ligand-binding site [chemical binding]; other site
742013016294	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
742013016295	intersubunit interface [polypeptide binding]; other site
742013016296	Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798
742013016297	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
742013016298	psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974
742013016299	Walker A motif; other site
742013016300	ATP binding site [chemical binding]; other site
742013016301	Walker B motif; other site
742013016302	arginine finger; other site
742013016303	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
742013016304	Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799
742013016305	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
742013016306	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
742013016307	Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042
742013016308	CoA binding domain; Region: CoA_binding_2; pfam13380
742013016309	Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607
742013016310	ATP-grasp domain; Region: ATP-grasp_5; pfam13549
742013016311	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK06111
742013016312	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
742013016313	ATP-grasp domain; Region: ATP-grasp_4; cl17255
742013016314	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785
742013016315	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
742013016316	carboxyltransferase (CT) interaction site; other site
742013016317	biotinylation site [posttranslational modification]; other site
742013016318	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
742013016319	CoenzymeA binding site [chemical binding]; other site
742013016320	subunit interaction site [polypeptide binding]; other site
742013016321	PHB binding site; other site
742013016322	heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386
742013016323	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
742013016324	dimerization interface [polypeptide binding]; other site
742013016325	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
742013016326	dimer interface [polypeptide binding]; other site
742013016327	phosphorylation site [posttranslational modification]
742013016328	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
742013016329	ATP binding site [chemical binding]; other site
742013016330	G-X-G motif; other site
742013016331	heavy metal response regulator; Region: cztR_silR_copR; TIGR01387
742013016332	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
742013016333	active site
742013016334	phosphorylation site [posttranslational modification]
742013016335	intermolecular recognition site; other site
742013016336	dimerization interface [polypeptide binding]; other site
742013016337	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
742013016338	DNA binding site [nucleotide binding]
742013016339	Outer membrane efflux protein; Region: OEP; pfam02321
742013016340	Outer membrane efflux protein; Region: OEP; pfam02321
742013016341	Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999
742013016342	HlyD family secretion protein; Region: HlyD_3; pfam13437
742013016343	heavy metal efflux pump, CzcA family; Region: 2A0601; TIGR00914
742013016344	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
742013016345	Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133
742013016346	Pseudomonas sp. MCI3434 R-amidase and related proteins (putative class 13 nitrilases); Region: R-amidase_like; cd07576
742013016347	Predicted amidohydrolase [General function prediction only]; Region: COG0388
742013016348	putative active site [active]
742013016349	catalytic triad [active]
742013016350	putative dimer interface [polypeptide binding]; other site
742013016351	bifunctional HTH-domain containing protein/aminotransferase; Provisional; Region: PRK13355
742013016352	glycolate oxidase subunit GlcD; Provisional; Region: PRK11230
742013016353	FAD binding domain; Region: FAD_binding_4; pfam01565
742013016354	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
742013016355	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
742013016356	The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432
742013016357	dimerization interface [polypeptide binding]; other site
742013016358	substrate binding pocket [chemical binding]; other site
742013016359	formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027
742013016360	N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875
742013016361	Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648
742013016362	putative active site [active]
742013016363	putative substrate binding site [chemical binding]; other site
742013016364	putative cosubstrate binding site; other site
742013016365	catalytic site [active]
742013016366	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
742013016367	PAS domain; Region: PAS_9; pfam13426
742013016368	putative active site [active]
742013016369	heme pocket [chemical binding]; other site
742013016370	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
742013016371	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
742013016372	metal binding site [ion binding]; metal-binding site
742013016373	active site
742013016374	I-site; other site
742013016375	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
742013016376	bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289
742013016377	Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040
742013016378	heme-binding site [chemical binding]; other site
742013016379	FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184
742013016380	FAD binding pocket [chemical binding]; other site
742013016381	FAD binding motif [chemical binding]; other site
742013016382	phosphate binding motif [ion binding]; other site
742013016383	beta-alpha-beta structure motif; other site
742013016384	NAD binding pocket [chemical binding]; other site
742013016385	Heme binding  pocket [chemical binding]; other site
742013016386	anaerobic nitric oxide reductase transcription regulator; Provisional; Region: PRK05022
742013016387	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
742013016388	Walker A motif; other site
742013016389	ATP binding site [chemical binding]; other site
742013016390	Walker B motif; other site
742013016391	arginine finger; other site
742013016392	FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545
742013016393	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
742013016394	Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075
742013016395	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
742013016396	catalytic residue [active]
742013016397	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
742013016398	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
742013016399	ATP-grasp domain; Region: ATP-grasp_4; cl17255
742013016400	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785
742013016401	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
742013016402	carboxyltransferase (CT) interaction site; other site
742013016403	biotinylation site [posttranslational modification]; other site
742013016404	Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799
742013016405	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
742013016406	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
742013016407	acyl-CoA synthetase; Validated; Region: PRK06178
742013016408	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
742013016409	acyl-activating enzyme (AAE) consensus motif; other site
742013016410	AMP binding site [chemical binding]; other site
742013016411	active site
742013016412	CoA binding site [chemical binding]; other site
742013016413	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
742013016414	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
742013016415	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
742013016416	Periplasmic solute-binding domain of active transport proteins; Region: PBP1_SBP_like_3; cd06329
742013016417	putative ligand binding site [chemical binding]; other site
742013016418	Pyridoxal 5-phosphate (PLP)-binding TIM barrel domain of Type III PLP-Dependent Enzymes, Yggs-like proteins; Region: PLPDE_III_Yggs_like; cd06824
742013016419	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
742013016420	catalytic residue [active]
742013016421	Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805
742013016422	Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131
742013016423	Walker A motif; other site
742013016424	ATP binding site [chemical binding]; other site
742013016425	Walker B motif; other site
742013016426	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
742013016427	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
742013016428	ligand binding site [chemical binding]; other site
742013016429	Tfp pilus assembly protein, ATPase PilU [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilU; COG5008
742013016430	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
742013016431	Walker A motif; other site
742013016432	ATP binding site [chemical binding]; other site
742013016433	Walker B motif; other site
742013016434	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
742013016435	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
742013016436	BON domain; Region: BON; pfam04972
742013016437	BON domain; Region: BON; pfam04972
742013016438	Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006
742013016439	dimer interface [polypeptide binding]; other site
742013016440	active site
742013016441	hypothetical protein; Provisional; Region: PRK14673
742013016442	Predicted methyltransferases [General function prediction only]; Region: COG0313
742013016443	Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648
742013016444	putative SAM binding site [chemical binding]; other site
742013016445	putative homodimer interface [polypeptide binding]; other site
742013016446	Escherichia coli YegD, a putative chaperone protein, and related proteins; Region: YegD_like; cd10231
742013016447	putative chaperone; Provisional; Region: PRK11678
742013016448	nucleotide binding site [chemical binding]; other site
742013016449	putative NEF/HSP70 interaction site [polypeptide binding]; other site
742013016450	SBD interface [polypeptide binding]; other site
742013016451	Glyoxalase-like domain; Region: Glyoxalase_3; pfam13468
742013016452	OsmC-like protein; Region: OsmC; pfam02566
742013016453	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
742013016454	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_15; cd08492
742013016455	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
742013016456	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
742013016457	dimer interface [polypeptide binding]; other site
742013016458	conserved gate region; other site
742013016459	putative PBP binding loops; other site
742013016460	ABC-ATPase subunit interface; other site
742013016461	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
742013016462	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
742013016463	putative PBP binding loops; other site
742013016464	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
742013016465	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
742013016466	Walker A/P-loop; other site
742013016467	ATP binding site [chemical binding]; other site
742013016468	Q-loop/lid; other site
742013016469	ABC transporter signature motif; other site
742013016470	Walker B; other site
742013016471	D-loop; other site
742013016472	H-loop/switch region; other site
742013016473	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
742013016474	Walker A/P-loop; other site
742013016475	ATP binding site [chemical binding]; other site
742013016476	Q-loop/lid; other site
742013016477	ABC transporter signature motif; other site
742013016478	Walker B; other site
742013016479	D-loop; other site
742013016480	H-loop/switch region; other site
742013016481	putative FMN-dependent luciferase-like monooxygenase, KPN_01858 family; Region: LLM_KPN_01858; TIGR04027
742013016482	probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858
742013016483	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4950; cl17731
742013016484	Carboxymuconolactone decarboxylase family; Region: CMD; cl00460
742013016485	uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926
742013016486	Sodium:sulfate symporter transmembrane region; Region: Na_sulph_symp; pfam00939
742013016487	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
742013016488	transmembrane helices; other site
742013016489	50S ribosomal protein L17; Validated; Region: rplQ; PRK05591
742013016490	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
742013016491	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
742013016492	alphaNTD homodimer interface [polypeptide binding]; other site
742013016493	alphaNTD - beta interaction site [polypeptide binding]; other site
742013016494	alphaNTD - beta' interaction site [polypeptide binding]; other site
742013016495	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
742013016496	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
742013016497	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
742013016498	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
742013016499	RNA binding surface [nucleotide binding]; other site
742013016500	30S ribosomal protein S11; Validated; Region: PRK05309
742013016501	30S ribosomal protein S13; Validated; Region: rpsM; PRK05179
742013016502	30S ribosomal protein S13; Region: bact_S13; TIGR03631
742013016503	50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465
742013016504	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
742013016505	SecY translocase; Region: SecY; pfam00344
742013016506	50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592
742013016507	Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658
742013016508	23S rRNA binding site [nucleotide binding]; other site
742013016509	30S ribosomal protein S5; Validated; Region: rpsE; PRK00550
742013016510	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
742013016511	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
742013016512	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
742013016513	5S rRNA interface [nucleotide binding]; other site
742013016514	23S rRNA interface [nucleotide binding]; other site
742013016515	L5 interface [polypeptide binding]; other site
742013016516	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
742013016517	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
742013016518	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
742013016519	30S ribosomal protein S8; Validated; Region: rpsH; PRK00136
742013016520	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881
742013016521	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
742013016522	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
742013016523	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
742013016524	50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004
742013016525	KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089
742013016526	RNA binding site [nucleotide binding]; other site
742013016527	50S ribosomal protein L14; Validated; Region: rplN; PRK05483
742013016528	Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578
742013016529	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
742013016530	Predicted small integral membrane protein (DUF2160); Region: DUF2160; pfam09928
742013016531	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
742013016532	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
742013016533	dimer interface [polypeptide binding]; other site
742013016534	conserved gate region; other site
742013016535	putative PBP binding loops; other site
742013016536	ABC-ATPase subunit interface; other site
742013016537	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
742013016538	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
742013016539	putative PBP binding loops; other site
742013016540	dimer interface [polypeptide binding]; other site
742013016541	ABC-ATPase subunit interface; other site
742013016542	ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839
742013016543	ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259
742013016544	Walker A/P-loop; other site
742013016545	ATP binding site [chemical binding]; other site
742013016546	Q-loop/lid; other site
742013016547	ABC transporter signature motif; other site
742013016548	Walker B; other site
742013016549	D-loop; other site
742013016550	H-loop/switch region; other site
742013016551	TOBE domain; Region: TOBE_2; pfam08402
742013016552	ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839
742013016553	ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259
742013016554	Walker A/P-loop; other site
742013016555	ATP binding site [chemical binding]; other site
742013016556	Q-loop/lid; other site
742013016557	ABC transporter signature motif; other site
742013016558	Walker B; other site
742013016559	D-loop; other site
742013016560	H-loop/switch region; other site
742013016561	TOBE domain; Region: TOBE_2; pfam08402
742013016562	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
742013016563	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220
742013016564	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
742013016565	glycerol kinase; Provisional; Region: glpK; PRK00047
742013016566	Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786
742013016567	N- and C-terminal domain interface [polypeptide binding]; other site
742013016568	active site
742013016569	MgATP binding site [chemical binding]; other site
742013016570	catalytic site [active]
742013016571	metal binding site [ion binding]; metal-binding site
742013016572	glycerol binding site [chemical binding]; other site
742013016573	homotetramer interface [polypeptide binding]; other site
742013016574	homodimer interface [polypeptide binding]; other site
742013016575	FBP binding site [chemical binding]; other site
742013016576	protein IIAGlc interface [polypeptide binding]; other site
742013016577	Esterase-like activity of phytase; Region: Phytase-like; pfam13449
742013016578	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4246
742013016579	Transcriptional regulators [Transcription]; Region: FadR; COG2186
742013016580	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414
742013016581	DNA-binding site [nucleotide binding]; DNA binding site
742013016582	FCD domain; Region: FCD; pfam07729
742013016583	Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028
742013016584	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
742013016585	PYR/PP interface [polypeptide binding]; other site
742013016586	dimer interface [polypeptide binding]; other site
742013016587	TPP binding site [chemical binding]; other site
742013016588	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
742013016589	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568
742013016590	TPP-binding site [chemical binding]; other site
742013016591	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
742013016592	Glyoxalase-like domain; Region: Glyoxalase_3; pfam13468
742013016593	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
742013016594	pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880
742013016595	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232
742013016596	4-hydroxybenzoate octaprenyltransferase; Reviewed; Region: ubiA; PRK12848
742013016597	UbiA prenyltransferase family; Region: UbiA; pfam01040
742013016598	PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392
742013016599	active site
742013016600	DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783
742013016601	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
742013016602	dimerization interface [polypeptide binding]; other site
742013016603	DPS ferroxidase diiron center [ion binding]; other site
742013016604	ion pore; other site
742013016605	DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151
742013016606	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
742013016607	The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411
742013016608	dimerization interface [polypeptide binding]; other site
742013016609	MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300
742013016610	ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917
742013016611	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
742013016612	generic binding surface II; other site
742013016613	ssDNA binding site; other site
742013016614	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
742013016615	ATP binding site [chemical binding]; other site
742013016616	putative Mg++ binding site [ion binding]; other site
742013016617	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
742013016618	nucleotide binding region [chemical binding]; other site
742013016619	ATP-binding site [chemical binding]; other site
742013016620	Domain of unknown function (DUF3391); Region: DUF3391; pfam11871
742013016621	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
742013016622	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
742013016623	Zn2+ binding site [ion binding]; other site
742013016624	Mg2+ binding site [ion binding]; other site
742013016625	Queuosine biosynthesis protein; Region: Queuosine_synth; pfam02547
742013016626	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113
742013016627	ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604
742013016628	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
742013016629	Walker A/P-loop; other site
742013016630	ATP binding site [chemical binding]; other site
742013016631	Q-loop/lid; other site
742013016632	ABC transporter signature motif; other site
742013016633	Walker B; other site
742013016634	D-loop; other site
742013016635	H-loop/switch region; other site
742013016636	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
742013016637	ABC-ATPase subunit  interface; other site
742013016638	dimer interface [polypeptide binding]; other site
742013016639	putative PBP binding regions; other site
742013016640	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
742013016641	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
742013016642	ABC-ATPase subunit  interface; other site
742013016643	dimer interface [polypeptide binding]; other site
742013016644	putative PBP binding regions; other site
742013016645	Siderophore binding protein FatB.  These proteins have been shown to function as ABC-type initial receptors in the siderophore-mediated iron uptake in some eubacterial species.  They belong to the TroA superfamily of periplasmic metal binding proteins...; Region: FatB; cd01140
742013016646	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
742013016647	putative ligand binding residues [chemical binding]; other site
742013016648	enterobactin/ferric enterobactin esterase; Provisional; Region: PRK10439
742013016649	Domain of unknown function (DUF3327); Region: DUF3327; pfam11806
742013016650	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819
742013016651	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
742013016652	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
742013016653	N-terminal plug; other site
742013016654	ligand-binding site [chemical binding]; other site
742013016655	HPr kinase/phosphorylase; Provisional; Region: PRK05428
742013016656	HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603
742013016657	HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918
742013016658	Hpr binding site; other site
742013016659	active site
742013016660	homohexamer subunit interaction site [polypeptide binding]; other site
742013016661	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
742013016662	active site
742013016663	phosphorylation site [posttranslational modification]
742013016664	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
742013016665	30S subunit binding site; other site
742013016666	non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414
742013016667	ATP binding site [chemical binding]; other site
742013016668	active site
742013016669	substrate binding site [chemical binding]; other site
742013016670	intracellular protease, PfpI family; Region: PfpI; TIGR01382
742013016671	Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_1; cd03169
742013016672	conserved cys residue [active]
742013016673	phosphonate utilization associated putative membrane protein; Region: phn_DUF6; TIGR03340
742013016674	Transcriptional regulator [Transcription]; Region: LysR; COG0583
742013016675	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
742013016676	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
742013016677	dimerization interface [polypeptide binding]; other site
742013016678	Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443
742013016679	Nucleotide-binding domain of Escherichia coli HscC and similar proteins; Region: HscC_like_NBD; cd10235
742013016680	nucleotide binding site [chemical binding]; other site
742013016681	putative NEF/HSP70 interaction site [polypeptide binding]; other site
742013016682	SBD interface [polypeptide binding]; other site
742013016683	DnaJ molecular chaperone homology domain; Region: DnaJ; smart00271
742013016684	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
742013016685	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
742013016686	The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432
742013016687	dimerization interface [polypeptide binding]; other site
742013016688	substrate binding pocket [chemical binding]; other site
742013016689	hypothetical protein; Provisional; Region: PRK09266
742013016690	homodimer interface [polypeptide binding]; other site
742013016691	substrate-cofactor binding pocket; other site
742013016692	pyridoxal 5'-phosphate binding site [chemical binding]; other site
742013016693	catalytic residue [active]
742013016694	Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118
742013016695	ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956
742013016696	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
742013016697	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
742013016698	Walker A/P-loop; other site
742013016699	ATP binding site [chemical binding]; other site
742013016700	Q-loop/lid; other site
742013016701	ABC transporter signature motif; other site
742013016702	Walker B; other site
742013016703	D-loop; other site
742013016704	H-loop/switch region; other site
742013016705	AIR carboxylase; Region: AIRC; cl00310
742013016706	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
742013016707	phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019
742013016708	ATP-grasp domain; Region: ATP-grasp; pfam02222
742013016709	Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009
742013016710	Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481
742013016711	LabA_like proteins; Region: LabA_like; cd06167
742013016712	putative metal binding site [ion binding]; other site
742013016713	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
742013016714	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
742013016715	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
742013016716	putative active site [active]
742013016717	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
742013016718	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
742013016719	substrate binding site [chemical binding]; other site
742013016720	ATP binding site [chemical binding]; other site
742013016721	Uncharacterized protein conserved in bacteria (DUF2090); Region: DUF2090; pfam09863
742013016722	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3892
742013016723	KduI/IolB family; Region: KduI; pfam04962
742013016724	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
742013016725	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181
742013016726	Transcriptional regulator [Transcription]; Region: LysR; COG0583
742013016727	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
742013016728	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
742013016729	putative effector binding pocket; other site
742013016730	dimerization interface [polypeptide binding]; other site
742013016731	Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085
742013016732	methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722
742013016733	tetrameric interface [polypeptide binding]; other site
742013016734	NAD binding site [chemical binding]; other site
742013016735	catalytic residues [active]
742013016736	Outer membrane protein W [Cell envelope biogenesis, outer membrane]; Region: OmpW; COG3047
742013016737	Triacylglycerol lipase-like subfamily of the SGNH hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: Triacylglycerol_lipase_like; cd01847
742013016738	active site
742013016739	catalytic triad [active]
742013016740	oxyanion hole [active]
742013016741	D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 4) [Cell envelope biogenesis, outer membrane]; Region: DacB; COG2027
742013016742	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
742013016743	Glycoprotease family; Region: Peptidase_M22; pfam00814
742013016744	ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575
742013016745	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
742013016746	Coenzyme A binding pocket [chemical binding]; other site
742013016747	Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030
742013016748	Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598
742013016749	Escherichia coli Mg2+ transporter CorA_like subgroup; Region: EcCorA-like_1; cd12835
742013016750	Cl binding site [ion binding]; other site
742013016751	oligomer interface [polypeptide binding]; other site
742013016752	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
742013016753	homotrimer interaction site [polypeptide binding]; other site
742013016754	putative active site [active]
742013016755	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes Similar to D-Serine Dehydratase and D-Threonine Aldolase, Unknown Group 1; Region: PLPDE_III_DSD_D-TA_like_1; cd06812
742013016756	Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616
742013016757	dimer interface [polypeptide binding]; other site
742013016758	active site
742013016759	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
742013016760	substrate binding site [chemical binding]; other site
742013016761	catalytic residue [active]
742013016762	2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428
742013016763	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
742013016764	motif II; other site
742013016765	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
742013016766	putative choline sulfate-utilization transcription factor; Region: chol_sulf_TF; TIGR03418
742013016767	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
742013016768	dimerization interface [polypeptide binding]; other site
742013016769	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
742013016770	Major Facilitator Superfamily; Region: MFS_1; pfam07690
742013016771	putative substrate translocation pore; other site
742013016772	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
742013016773	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
742013016774	trimer interface [polypeptide binding]; other site
742013016775	eyelet of channel; other site
742013016776	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
742013016777	Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal  ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185
742013016778	FMN-binding pocket [chemical binding]; other site
742013016779	flavin binding motif; other site
742013016780	phosphate binding motif [ion binding]; other site
742013016781	beta-alpha-beta structure motif; other site
742013016782	NAD binding pocket [chemical binding]; other site
742013016783	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
742013016784	catalytic loop [active]
742013016785	iron binding site [ion binding]; other site
742013016786	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
742013016787	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
742013016788	[2Fe-2S] cluster binding site [ion binding]; other site
742013016789	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
742013016790	hydrophobic ligand binding site; other site
742013016791	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
742013016792	C-terminal domain of Burkholderia sp. NF100 MhqB and similar proteins; MhqB is a type I extradiol dioxygenase involved in the catabolism of methylhydroquinone, an intermediate in the degradation of fenitrothion; Region: MhqB_like_C; cd08360
742013016793	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
742013016794	putative active site [active]
742013016795	putative metal binding site [ion binding]; other site
742013016796	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
742013016797	Uncharacterized Candidatus pelagibacter aldehyde dehydrogenase, DhaS-like; Region: ALDH_DhaS; cd07114
742013016798	NAD(P) binding site [chemical binding]; other site
742013016799	catalytic residues [active]
742013016800	hypothetical protein; Provisional; Region: PRK07064
742013016801	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
742013016802	PYR/PP interface [polypeptide binding]; other site
742013016803	dimer interface [polypeptide binding]; other site
742013016804	TPP binding site [chemical binding]; other site
742013016805	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
742013016806	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568
742013016807	TPP-binding site [chemical binding]; other site
742013016808	short chain dehydrogenase; Provisional; Region: PRK07062
742013016809	putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344
742013016810	putative NAD(P) binding site [chemical binding]; other site
742013016811	putative active site [active]
742013016812	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
742013016813	Transcriptional regulator [Transcription]; Region: IclR; COG1414
742013016814	Bacterial transcriptional regulator; Region: IclR; pfam01614
742013016815	short chain dehydrogenase; Provisional; Region: PRK12939
742013016816	classical (c) SDRs; Region: SDR_c; cd05233
742013016817	NAD(P) binding site [chemical binding]; other site
742013016818	active site
742013016819	undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726
742013016820	Phage derived protein Gp49-like (DUF891); Region: Gp49; pfam05973
742013016821	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200
742013016822	5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584
742013016823	5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704
742013016824	L-aspartate dehydrogenase; Provisional; Region: PRK13303
742013016825	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
742013016826	Domain of unknown function DUF108; Region: DUF108; pfam01958
742013016827	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
742013016828	Transcriptional regulator [Transcription]; Region: IclR; COG1414
742013016829	Bacterial transcriptional regulator; Region: IclR; pfam01614
742013016830	3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427
742013016831	Cupin domain; Region: Cupin_2; pfam07883
742013016832	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
742013016833	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
742013016834	putative substrate translocation pore; other site
742013016835	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
742013016836	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807
742013016837	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
742013016838	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
742013016839	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
742013016840	Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412
742013016841	putative DNA binding site [nucleotide binding]; other site
742013016842	putative Zn2+ binding site [ion binding]; other site
742013016843	AsnC family; Region: AsnC_trans_reg; pfam01037
742013016844	Long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07059
742013016845	Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936
742013016846	acyl-activating enzyme (AAE) consensus motif; other site
742013016847	putative AMP binding site [chemical binding]; other site
742013016848	putative active site [active]
742013016849	putative CoA binding site [chemical binding]; other site
742013016850	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
742013016851	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
742013016852	active site
742013016853	catalytic tetrad [active]
742013016854	Transcriptional regulator [Transcription]; Region: LysR; COG0583
742013016855	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
742013016856	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
742013016857	dimerization interface [polypeptide binding]; other site
742013016858	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
742013016859	M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666
742013016860	metal binding site [ion binding]; metal-binding site
742013016861	putative dimer interface [polypeptide binding]; other site
742013016862	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
742013016863	tRNA-binding-domain-containing CsaA-like proteins. CsaA is a molecular chaperone with export related activities. CsaA has a putative tRNA binding activity. The functional unit of CsaA is a homodimer and this domain acts as a dimerization domain; Region: tRNA_bind_CsaA; cd02798
742013016864	dimer interface [polypeptide binding]; other site
742013016865	putative tRNA-binding site [nucleotide binding]; other site
742013016866	Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057
742013016867	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
742013016868	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
742013016869	transketolase; Reviewed; Region: PRK12753
742013016870	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
742013016871	TPP-binding site [chemical binding]; other site
742013016872	dimer interface [polypeptide binding]; other site
742013016873	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
742013016874	PYR/PP interface [polypeptide binding]; other site
742013016875	dimer interface [polypeptide binding]; other site
742013016876	TPP binding site [chemical binding]; other site
742013016877	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
742013016878	NTP_transferase_like_1 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_1; cd06422
742013016879	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
742013016880	Substrate binding site; other site
742013016881	metal-binding site
742013016882	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
742013016883	fructose-bisphosphate aldolase; Provisional; Region: PRK09197
742013016884	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
742013016885	intersubunit interface [polypeptide binding]; other site
742013016886	active site
742013016887	zinc binding site [ion binding]; other site
742013016888	Na+ binding site [ion binding]; other site
742013016889	sensor protein BasS/PmrB; Provisional; Region: PRK10755
742013016890	Histidine kinase-like ATPases; Region: HATPase_c; smart00387
742013016891	Mg2+ binding site [ion binding]; other site
742013016892	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
742013016893	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
742013016894	active site
742013016895	phosphorylation site [posttranslational modification]
742013016896	intermolecular recognition site; other site
742013016897	dimerization interface [polypeptide binding]; other site
742013016898	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
742013016899	DNA binding site [nucleotide binding]
742013016900	PAP2_like_6 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which mainly contains bacterial proteins, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_6; cd03396
742013016901	active site
742013016902	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
742013016903	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474
742013016904	active site
742013016905	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
742013016906	pyruvate kinase; Provisional; Region: PRK05826
742013016907	domain interfaces; other site
742013016908	active site
742013016909	Putative cyclase; Region: Cyclase; pfam04199
742013016910	Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936
742013016911	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08314
742013016912	acyl-activating enzyme (AAE) consensus motif; other site
742013016913	putative AMP binding site [chemical binding]; other site
742013016914	putative active site [active]
742013016915	putative CoA binding site [chemical binding]; other site
742013016916	TIGR03118 family protein; Region: PEPCTERM_chp_1
742013016917	Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195
742013016918	proline aminopeptidase P II; Provisional; Region: PRK10879
742013016919	Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087
742013016920	active site
742013016921	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
742013016922	active site residue [active]
742013016923	Protein of unknown function (DUF2892); Region: DUF2892; pfam11127
742013016924	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
742013016925	dimerization interface [polypeptide binding]; other site
742013016926	putative DNA binding site [nucleotide binding]; other site
742013016927	putative Zn2+ binding site [ion binding]; other site
742013016928	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
742013016929	Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765
742013016930	Pirin; Region: Pirin; pfam02678
742013016931	Pirin-related protein [General function prediction only]; Region: COG1741
742013016932	Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726
742013016933	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cl00250
742013016934	30S subunit binding site; other site
742013016935	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745
742013016936	Peptidase C26; Region: Peptidase_C26; pfam07722
742013016937	catalytic triad [active]
742013016938	Transcriptional regulator [Transcription]; Region: LysR; COG0583
742013016939	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
742013016940	The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417
742013016941	substrate binding pocket [chemical binding]; other site
742013016942	dimerization interface [polypeptide binding]; other site
742013016943	The A subunit of Uncharacterized proteins with similarity to Protocatechuate 4,5-dioxygenase (LigAB); Region: LigA_like_1; cd07925
742013016944	putative dimer interface [polypeptide binding]; other site
742013016945	putative tetramer interface [polypeptide binding]; other site
742013016946	putative active site [active]
742013016947	The B subunit of unknown Class III extradiol dioxygenases with similarity to Protocatechuate 4,5-dioxygenase; Region: PCA_45_Doxase_B_like_1; cd07949
742013016948	Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900
742013016949	putative active site [active]
742013016950	Fe(II) binding site [ion binding]; other site
742013016951	putative dimer interface [polypeptide binding]; other site
742013016952	putative tetramer interface [polypeptide binding]; other site
742013016953	FKBP-type peptidyl-prolyl cis-trans isomerases 2 [Posttranslational modification, protein turnover, chaperones]; Region: SlpA; COG1047
742013016954	Transcriptional regulator [Transcription]; Region: LysR; COG0583
742013016955	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
742013016956	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
742013016957	dimerization interface [polypeptide binding]; other site
742013016958	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
742013016959	Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013
742013016960	tetramer interface [polypeptide binding]; other site
742013016961	Carboxymuconolactone decarboxylase family; Region: CMD; cl00460
742013016962	Pirin-related protein [General function prediction only]; Region: COG1741
742013016963	Pirin; Region: Pirin; pfam02678
742013016964	Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726
742013016965	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
742013016966	GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048
742013016967	C-terminal domain interface [polypeptide binding]; other site
742013016968	GSH binding site (G-site) [chemical binding]; other site
742013016969	dimer interface [polypeptide binding]; other site
742013016970	C-terminal, alpha helical domain of Ure2p and related Glutathione S-transferase-like proteins; Region: GST_C_Ure2p_like; cd03178
742013016971	dimer interface [polypeptide binding]; other site
742013016972	N-terminal domain interface [polypeptide binding]; other site
742013016973	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
742013016974	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
742013016975	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
742013016976	trimer interface [polypeptide binding]; other site
742013016977	eyelet of channel; other site
742013016978	putative DNA-binding transcriptional regulator; Provisional; Region: PRK09775
742013016979	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220
742013016980	putative DNA binding site [nucleotide binding]; other site
742013016981	HipA-like N-terminal domain; Region: HipA_N; pfam07805
742013016982	HipA-like C-terminal domain; Region: HipA_C; pfam07804
742013016983	Bacterial protein of unknown function (DUF924); Region: DUF924; pfam06041
742013016984	Acyltransferase family; Region: Acyl_transf_3; pfam01757
742013016985	Uncharacterized conserved protein [Function unknown]; Region: COG3148
742013016986	Methyltransferase domain; Region: Methyltransf_23; pfam13489
742013016987	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
742013016988	S-adenosylmethionine binding site [chemical binding]; other site
742013016989	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
742013016990	amidase catalytic site [active]
742013016991	Zn binding residues [ion binding]; other site
742013016992	substrate binding site [chemical binding]; other site
742013016993	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
742013016994	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262
742013016995	exonuclease subunit SbcD; Provisional; Region: PRK10966
742013016996	Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840
742013016997	active site
742013016998	metal binding site [ion binding]; metal-binding site
742013016999	DNA binding site [nucleotide binding]
742013017000	Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320
742013017001	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
742013017002	AAA domain; Region: AAA_23; pfam13476
742013017003	Walker A/P-loop; other site
742013017004	ATP binding site [chemical binding]; other site
742013017005	Q-loop/lid; other site
742013017006	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
742013017007	ABC transporter signature motif; other site
742013017008	Walker B; other site
742013017009	D-loop; other site
742013017010	H-loop/switch region; other site
742013017011	RDD family; Region: RDD; pfam06271
742013017012	Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964
742013017013	active site
742013017014	homotetramer interface [polypeptide binding]; other site
742013017015	homodimer interface [polypeptide binding]; other site
742013017016	Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340
742013017017	catalytic residues [active]
742013017018	dimer interface [polypeptide binding]; other site
742013017019	Ferritin-like domain; Region: Ferritin; pfam00210
742013017020	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657
742013017021	dinuclear metal binding motif [ion binding]; other site
742013017022	Transglycosylase; Region: Transgly; pfam00912
742013017023	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
742013017024	Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350
742013017025	Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348
742013017026	DNA topoisomerase III; Validated; Region: PRK08173
742013017027	TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362
742013017028	active site
742013017029	putative interdomain interaction site [polypeptide binding]; other site
742013017030	putative metal-binding site [ion binding]; other site
742013017031	putative nucleotide binding site [chemical binding]; other site
742013017032	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
742013017033	domain I; other site
742013017034	DNA binding groove [nucleotide binding]
742013017035	phosphate binding site [ion binding]; other site
742013017036	domain II; other site
742013017037	domain III; other site
742013017038	nucleotide binding site [chemical binding]; other site
742013017039	catalytic site [active]
742013017040	domain IV; other site
742013017041	C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342
742013017042	C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342
742013017043	SWI complex, BAF60b domains; Region: SWIB; smart00151
742013017044	Proteins containing SET domain [General function prediction only]; Region: COG2940
742013017045	SET domain; Region: SET; pfam00856
742013017046	Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340
742013017047	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099
742013017048	Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237
742013017049	N-formylglutamate amidohydrolase; Region: FGase; pfam05013
742013017050	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181
742013017051	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
742013017052	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
742013017053	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
742013017054	dimerization interface [polypeptide binding]; other site
742013017055	Two-component sensor kinase N-terminal; Region: 2CSK_N; pfam08521
742013017056	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
742013017057	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
742013017058	dimer interface [polypeptide binding]; other site
742013017059	phosphorylation site [posttranslational modification]
742013017060	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
742013017061	ATP binding site [chemical binding]; other site
742013017062	Mg2+ binding site [ion binding]; other site
742013017063	G-X-G motif; other site
742013017064	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
742013017065	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
742013017066	active site
742013017067	phosphorylation site [posttranslational modification]
742013017068	intermolecular recognition site; other site
742013017069	dimerization interface [polypeptide binding]; other site
742013017070	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
742013017071	DNA binding site [nucleotide binding]
742013017072	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
742013017073	hexamer interface [polypeptide binding]; other site
742013017074	RecA/RadA recombinase [DNA replication, recombination, and repair]; Region: RecA; COG0468
742013017075	Walker A motif; other site
742013017076	ATP binding site [chemical binding]; other site
742013017077	Walker B motif; other site
742013017078	RecX family; Region: RecX; cl00936
742013017079	aromatic amino acid exporter; Provisional; Region: PRK11689
742013017080	EamA-like transporter family; Region: EamA; pfam00892
742013017081	N-acetyl-gamma-glutamyl-phosphate reductase; Provisional; Region: PRK11863
742013017082	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
742013017083	succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696
742013017084	ATP-grasp domain; Region: ATP-grasp_2; pfam08442
742013017085	CoA-ligase; Region: Ligase_CoA; pfam00549
742013017086	succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678
742013017087	CoA binding domain; Region: CoA_binding; smart00881
742013017088	CoA-ligase; Region: Ligase_CoA; pfam00549
742013017089	integral membrane protein, YjbE family; Region: R_switched_YjbE; TIGR03717
742013017090	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
742013017091	Protein phosphatase 2C; Region: PP2C; pfam00481
742013017092	active site
742013017093	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
742013017094	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
742013017095	phosphopeptide binding site; other site
742013017096	Pilin (bacterial filament); Region: Pilin; pfam00114
742013017097	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
742013017098	TPR motif; other site
742013017099	binding surface
742013017100	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
742013017101	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
742013017102	NAD(P) binding site [chemical binding]; other site
742013017103	active site
742013017104	FAD binding domain; Region: FAD_binding_4; pfam01565
742013017105	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
742013017106	GtrA-like protein; Region: GtrA; pfam04138
742013017107	phosphoribose diphosphate:decaprenyl-phosphate phosphoribosyltransferase; Provisional; Region: PRK12324
742013017108	Divergent PAP2 family; Region: DUF212; pfam02681
742013017109	MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420
742013017110	trimer interface [polypeptide binding]; other site
742013017111	dimer interface [polypeptide binding]; other site
742013017112	putative active site [active]
742013017113	Peptidase family M48; Region: Peptidase_M48; pfam01435
742013017114	Membrane protein of unknown function; Region: DUF360; pfam04020
742013017115	integral membrane protein, YjbE family; Region: R_switched_YjbE; TIGR03717
742013017116	Protein of unknown function (DUF3717); Region: DUF3717; pfam12512
742013017117	Protein of unknown function (DUF1289); Region: DUF1289; pfam06945
742013017118	YaeQ protein; Region: YaeQ; pfam07152
742013017119	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
742013017120	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
742013017121	adenylosuccinate lyase; Provisional; Region: PRK09285
742013017122	PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598
742013017123	tetramer interface [polypeptide binding]; other site
742013017124	active site
742013017125	putative glutathione S-transferase; Provisional; Region: PRK10357
742013017126	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
742013017127	C-terminal, alpha helical domain of an unknown subfamily 6 of Glutathione S-transferases; Region: GST_C_6; cd03205
742013017128	dimer interface [polypeptide binding]; other site
742013017129	N-terminal domain interface [polypeptide binding]; other site
742013017130	bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Reviewed; Region: PRK11072
742013017131	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
742013017132	metal binding triad; other site
742013017133	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
742013017134	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
742013017135	metal binding triad; other site
742013017136	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
742013017137	TIGR02099 family protein; Region: TIGR02099
742013017138	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
742013017139	nitrilase; Region: PLN02798
742013017140	Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572
742013017141	putative active site [active]
742013017142	catalytic triad [active]
742013017143	dimer interface [polypeptide binding]; other site
742013017144	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
742013017145	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
742013017146	putative active site [active]
742013017147	heme pocket [chemical binding]; other site
742013017148	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
742013017149	ATP binding site [chemical binding]; other site
742013017150	Mg2+ binding site [ion binding]; other site
742013017151	G-X-G motif; other site
742013017152	Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566
742013017153	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
742013017154	active site
742013017155	phosphorylation site [posttranslational modification]
742013017156	intermolecular recognition site; other site
742013017157	dimerization interface [polypeptide binding]; other site
742013017158	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
742013017159	DNA binding residues [nucleotide binding]
742013017160	dimerization interface [polypeptide binding]; other site
742013017161	Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616
742013017162	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Bacterial Cryptic D-Serine Dehydratase; Region: PLPDE_III_cryptic_DSD; cd06818
742013017163	dimer interface [polypeptide binding]; other site
742013017164	active site
742013017165	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
742013017166	substrate binding site [chemical binding]; other site
742013017167	catalytic residue [active]
742013017168	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
742013017169	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
742013017170	ligand binding site [chemical binding]; other site
742013017171	MltA specific insert domain; Region: MltA; smart00925
742013017172	3D domain; Region: 3D; pfam06725
742013017173	Transmembrane secretion effector; Region: MFS_3; pfam05977
742013017174	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
742013017175	putative substrate translocation pore; other site
742013017176	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
742013017177	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
742013017178	putative DNA binding site [nucleotide binding]; other site
742013017179	putative Zn2+ binding site [ion binding]; other site
742013017180	AsnC family; Region: AsnC_trans_reg; pfam01037
742013017181	indolepyruvate ferredoxin oxidoreductase; Validated; Region: PRK09193
742013017182	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
742013017183	dimer interface [polypeptide binding]; other site
742013017184	PYR/PP interface [polypeptide binding]; other site
742013017185	TPP binding site [chemical binding]; other site
742013017186	substrate binding site [chemical binding]; other site
742013017187	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629
742013017188	TPP-binding site [chemical binding]; other site
742013017189	Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014
742013017190	preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585
742013017191	SecD export protein N-terminal TM region; Region: SecD-TM1; pfam13721
742013017192	preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812
742013017193	SecD/SecF GG Motif; Region: Sec_GG; pfam07549
742013017194	protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916
742013017195	preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022
742013017196	SecD/SecF GG Motif; Region: Sec_GG; pfam07549
742013017197	Protein export membrane protein; Region: SecD_SecF; pfam02355
742013017198	Protein of unknown function (DUF1631); Region: DUF1631; pfam07793
742013017199	Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758
742013017200	DNA protecting protein DprA; Region: dprA; TIGR00732
742013017201	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
742013017202	Uncharacterized protein containing LysM domain [Function unknown]; Region: XkdP; COG1652
742013017203	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
742013017204	active site
742013017205	catalytic residues [active]
742013017206	metal binding site [ion binding]; metal-binding site
742013017207	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
742013017208	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
742013017209	putative active site [active]
742013017210	substrate binding site [chemical binding]; other site
742013017211	putative cosubstrate binding site; other site
742013017212	catalytic site [active]
742013017213	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
742013017214	substrate binding site [chemical binding]; other site
742013017215	AzlC protein; Region: AzlC; pfam03591
742013017216	Branched-chain amino acid transport protein (AzlD); Region: AzlD; pfam05437
742013017217	phosphoglycerate kinase; Provisional; Region: pgk; PRK00073
742013017218	Phosphoglycerate kinase; Region: PGK; pfam00162
742013017219	substrate binding site [chemical binding]; other site
742013017220	hinge regions; other site
742013017221	ADP binding site [chemical binding]; other site
742013017222	catalytic site [active]
742013017223	putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272
742013017224	EamA-like transporter family; Region: EamA; pfam00892
742013017225	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725
742013017226	active site
742013017227	dimer interface [polypeptide binding]; other site
742013017228	cell density-dependent motility repressor; Provisional; Region: PRK10082
742013017229	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
742013017230	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
742013017231	dimerization interface [polypeptide binding]; other site
742013017232	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
742013017233	M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393
742013017234	active site
742013017235	Zn binding site [ion binding]; other site
742013017236	hydroxyglutarate oxidase; Provisional; Region: PRK11728
742013017237	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
742013017238	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
742013017239	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
742013017240	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
742013017241	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
742013017242	Major Facilitator Superfamily; Region: MFS_1; pfam07690
742013017243	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
742013017244	putative substrate translocation pore; other site
742013017245	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
742013017246	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
742013017247	dimer interface [polypeptide binding]; other site
742013017248	ssDNA binding site [nucleotide binding]; other site
742013017249	tetramer (dimer of dimers) interface [polypeptide binding]; other site
742013017250	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
742013017251	non-specific DNA binding site [nucleotide binding]; other site
742013017252	salt bridge; other site
742013017253	sequence-specific DNA binding site [nucleotide binding]; other site
742013017254	HipA N-terminal domain; Region: Couple_hipA; cl11853
742013017255	HipA-like N-terminal domain; Region: HipA_N; pfam07805
742013017256	HipA-like C-terminal domain; Region: HipA_C; pfam07804
742013017257	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
742013017258	Sulfate transporter family; Region: Sulfate_transp; pfam00916
742013017259	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
742013017260	phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160
742013017261	NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214
742013017262	FAD binding pocket [chemical binding]; other site
742013017263	FAD binding motif [chemical binding]; other site
742013017264	phosphate binding motif [ion binding]; other site
742013017265	beta-alpha-beta structure motif; other site
742013017266	NAD(p) ribose binding residues [chemical binding]; other site
742013017267	NAD binding pocket [chemical binding]; other site
742013017268	NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site
742013017269	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
742013017270	catalytic loop [active]
742013017271	iron binding site [ion binding]; other site
742013017272	Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151
742013017273	phenylacetate-CoA oxygenase, PaaJ subunit; Region: PA_CoA_Oxy4; TIGR02159
742013017274	Phenylacetic acid catabolic protein; Region: PaaA_PaaC; pfam05138
742013017275	phenylacetate-CoA oxygenase subunit PaaB; Provisional; Region: paaB; PRK13781
742013017276	phenylacetate-CoA oxygenase subunit PaaA; Provisional; Region: paaA; PRK13778
742013017277	phenylacetate-CoA oxygenase, PaaG subunit; Region: PA_CoA_Oxy1; TIGR02156
742013017278	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
742013017279	phenylacetate-CoA ligase; Region: PA_CoA_ligase; TIGR02155
742013017280	acyl-activating enzyme (AAE) consensus motif; other site
742013017281	AMP binding site [chemical binding]; other site
742013017282	active site
742013017283	CoA binding site [chemical binding]; other site
742013017284	phenylacetic acid degradation protein paaN; Region: PaaN_2; TIGR02288
742013017285	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
742013017286	NAD(P) binding site [chemical binding]; other site
742013017287	catalytic residues [active]
742013017288	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
742013017289	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
742013017290	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
742013017291	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
742013017292	active site
742013017293	phosphorylation site [posttranslational modification]
742013017294	intermolecular recognition site; other site
742013017295	dimerization interface [polypeptide binding]; other site
742013017296	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
742013017297	DNA binding residues [nucleotide binding]
742013017298	dimerization interface [polypeptide binding]; other site
742013017299	7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695
742013017300	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
742013017301	ATP binding site [chemical binding]; other site
742013017302	Mg2+ binding site [ion binding]; other site
742013017303	G-X-G motif; other site
742013017304	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
742013017305	Beta-lactamase; Region: Beta-lactamase; pfam00144
742013017306	Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482
742013017307	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
742013017308	Ligand Binding Site [chemical binding]; other site
742013017309	Transcriptional regulator [Transcription]; Region: LysR; COG0583
742013017310	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
742013017311	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_1; cd08421
742013017312	putative dimerization interface [polypeptide binding]; other site
742013017313	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
742013017314	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
742013017315	substrate binding site [chemical binding]; other site
742013017316	oxyanion hole (OAH) forming residues; other site
742013017317	trimer interface [polypeptide binding]; other site
742013017318	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
742013017319	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
742013017320	CoA-transferase family III; Region: CoA_transf_3; pfam02515
742013017321	Citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CCL cleaves citryl-CoA (CiCoA) to acetyl-CoA (AcCoA) and oxaloacetate (OAA); Region: CCL_ACL-C; cd06100
742013017322	active site
742013017323	oxalacetate binding site [chemical binding]; other site
742013017324	citrylCoA binding site [chemical binding]; other site
742013017325	coenzyme A binding site [chemical binding]; other site
742013017326	catalytic triad [active]
742013017327	acyl-CoA synthetase; Validated; Region: PRK06188
742013017328	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
742013017329	Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929
742013017330	acyl-activating enzyme (AAE) consensus motif; other site
742013017331	acyl-activating enzyme (AAE) consensus motif; other site
742013017332	putative AMP binding site [chemical binding]; other site
742013017333	putative active site [active]
742013017334	putative CoA binding site [chemical binding]; other site
742013017335	Transcriptional regulator [Transcription]; Region: IclR; COG1414
742013017336	IclR helix-turn-helix domain; Region: HTH_IclR; cl17605
742013017337	Bacterial transcriptional regulator; Region: IclR; pfam01614
742013017338	nitrogen assimilation transcriptional regulator; Provisional; Region: PRK11233
742013017339	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
742013017340	The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433
742013017341	putative dimerization interface [polypeptide binding]; other site
742013017342	tricarballylate dehydrogenase; Validated; Region: PRK08274
742013017343	tricarballylate utilization protein B; Provisional; Region: PRK15033
742013017344	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
742013017345	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
742013017346	Uncharacterized conserved protein [Function unknown]; Region: COG2128
742013017347	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
742013017348	Isopentenyl diphosphate isomerase (BS_ypgA, MTH48 and related proteins) [Coenzyme transport and metabolism]; Region: idi; COG1304
742013017349	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
742013017350	phosphate binding site [ion binding]; other site
742013017351	Transcriptional regulator [Transcription]; Region: LysR; COG0583
742013017352	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
742013017353	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
742013017354	dimerization interface [polypeptide binding]; other site
742013017355	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
742013017356	non-specific DNA binding site [nucleotide binding]; other site
742013017357	salt bridge; other site
742013017358	sequence-specific DNA binding site [nucleotide binding]; other site
742013017359	Transcriptional regulators [Transcription]; Region: PurR; COG1609
742013017360	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
742013017361	DNA binding site [nucleotide binding]
742013017362	domain linker motif; other site
742013017363	Ligand binding domain of DNA transcription repressor specific for fructose (FruR) and its close homologs; Region: PBP1_FruR; cd06274
742013017364	dimerization interface [polypeptide binding]; other site
742013017365	ligand binding site [chemical binding]; other site
742013017366	Periplasmic binding domain of autoinducer-2 (AI-2) receptor LsrB from Salmonella typhimurium and its close homologs; Region: PBP1_LsrB_Quorum_Sensing; cd06302
742013017367	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
742013017368	ligand binding site [chemical binding]; other site
742013017369	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
742013017370	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
742013017371	Walker A/P-loop; other site
742013017372	ATP binding site [chemical binding]; other site
742013017373	Q-loop/lid; other site
742013017374	ABC transporter signature motif; other site
742013017375	Walker B; other site
742013017376	D-loop; other site
742013017377	H-loop/switch region; other site
742013017378	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
742013017379	Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454
742013017380	TM-ABC transporter signature motif; other site
742013017381	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
742013017382	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
742013017383	TM-ABC transporter signature motif; other site
742013017384	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
742013017385	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060
742013017386	DNA interaction; other site
742013017387	Metal-binding active site; metal-binding site
742013017388	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
742013017389	Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405
742013017390	Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019
742013017391	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
742013017392	Transcriptional regulator [Transcription]; Region: LysR; COG0583
742013017393	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
742013017394	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
742013017395	dimerization interface [polypeptide binding]; other site
742013017396	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882
742013017397	G1 box; other site
742013017398	GTP/Mg2+ binding site [chemical binding]; other site
742013017399	G2 box; other site
742013017400	Switch I region; other site
742013017401	G3 box; other site
742013017402	Switch II region; other site
742013017403	G4 box; other site
742013017404	G5 box; other site
742013017405	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
742013017406	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
742013017407	ligand binding site [chemical binding]; other site
742013017408	flexible hinge region; other site
742013017409	Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545
742013017410	non-specific DNA interactions [nucleotide binding]; other site
742013017411	DNA binding site [nucleotide binding]
742013017412	sequence specific DNA binding site [nucleotide binding]; other site
742013017413	putative cAMP binding site [chemical binding]; other site
742013017414	Alkyl sulfatase and related hydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2015
742013017415	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
742013017416	SCP-2 sterol transfer family; Region: SCP2; pfam02036
742013017417	Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027
742013017418	ligand binding site [chemical binding]; other site
742013017419	active site
742013017420	UGI interface [polypeptide binding]; other site
742013017421	catalytic site [active]
742013017422	Toxin module HipA, protein kinase of phosphatidylinositol 3/4-kinase superfamily [General function prediction only]; Region: HipA; COG3550
742013017423	HipA-like N-terminal domain; Region: HipA_N; pfam07805
742013017424	HipA-like C-terminal domain; Region: HipA_C; pfam07804
742013017425	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
742013017426	non-specific DNA binding site [nucleotide binding]; other site
742013017427	salt bridge; other site
742013017428	sequence-specific DNA binding site [nucleotide binding]; other site
742013017429	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
742013017430	active site
742013017431	ribulose/triose binding site [chemical binding]; other site
742013017432	phosphate binding site [ion binding]; other site
742013017433	substrate (anthranilate) binding pocket [chemical binding]; other site
742013017434	product (indole) binding pocket [chemical binding]; other site
742013017435	anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188
742013017436	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
742013017437	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
742013017438	para-aminobenzoate synthase component II; Provisional; Region: PRK08857
742013017439	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
742013017440	glutamine binding [chemical binding]; other site
742013017441	catalytic triad [active]
742013017442	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
742013017443	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
742013017444	metal ion-dependent adhesion site (MIDAS); other site
742013017445	Toxic anion resistance protein (TelA); Region: TelA; pfam05816
742013017446	enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK07533
742013017447	Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372
742013017448	NAD binding site [chemical binding]; other site
742013017449	homotetramer interface [polypeptide binding]; other site
742013017450	homodimer interface [polypeptide binding]; other site
742013017451	substrate binding site [chemical binding]; other site
742013017452	active site
742013017453	copper/silver efflux system outer membrane protein CusC; Provisional; Region: PRK09837
742013017454	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
742013017455	HlyD family secretion protein; Region: HlyD_3; pfam13437
742013017456	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
742013017457	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
742013017458	Walker A/P-loop; other site
742013017459	ATP binding site [chemical binding]; other site
742013017460	Q-loop/lid; other site
742013017461	ABC transporter signature motif; other site
742013017462	Walker B; other site
742013017463	D-loop; other site
742013017464	H-loop/switch region; other site
742013017465	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
742013017466	Walker A/P-loop; other site
742013017467	ATP binding site [chemical binding]; other site
742013017468	Q-loop/lid; other site
742013017469	ABC transporter signature motif; other site
742013017470	Walker B; other site
742013017471	D-loop; other site
742013017472	H-loop/switch region; other site
742013017473	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
742013017474	ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679
742013017475	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
742013017476	YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061
742013017477	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
742013017478	Protein of unknown function (DUF3141); Region: DUF3141; pfam11339
742013017479	bifunctional enoyl-CoA hydratase/phosphate acetyltransferase; Validated; Region: PRK08190
742013017480	(R)-hydratase [(R)-specific enoyl-CoA hydratase] catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. (R)-hydratase contains a hot-dog fold similar to those of thioesterase...; Region: R_hydratase; cd03449
742013017481	dimer interaction site [polypeptide binding]; other site
742013017482	substrate-binding tunnel; other site
742013017483	active site
742013017484	catalytic site [active]
742013017485	substrate binding site [chemical binding]; other site
742013017486	phosphate acetyltransferase; Provisional; Region: PRK11890
742013017487	Acetate kinase [Energy production and conversion]; Region: ackA; COG0282
742013017488	propionate/acetate kinase; Provisional; Region: PRK12379
742013017489	Chorismate mutase type II; Region: CM_2; cl00693
742013017490	anthranilate synthase component I; Provisional; Region: PRK13565
742013017491	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
742013017492	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
742013017493	Patatin-like phospholipase; includes PNPLA8, PNPLA9, and Pat17; Region: Pat17_PNPLA8_PNPLA9_like; cd07199
742013017494	active site
742013017495	nucleophile elbow; other site
742013017496	Chalcone-flavanone isomerase; Region: Chalcone; cl03589
742013017497	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
742013017498	HAMP domain; Region: HAMP; pfam00672
742013017499	dimerization interface [polypeptide binding]; other site
742013017500	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
742013017501	dimer interface [polypeptide binding]; other site
742013017502	phosphorylation site [posttranslational modification]
742013017503	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
742013017504	ATP binding site [chemical binding]; other site
742013017505	Mg2+ binding site [ion binding]; other site
742013017506	G-X-G motif; other site
742013017507	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
742013017508	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
742013017509	active site
742013017510	phosphorylation site [posttranslational modification]
742013017511	intermolecular recognition site; other site
742013017512	dimerization interface [polypeptide binding]; other site
742013017513	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355
742013017514	DNA binding site [nucleotide binding]
742013017515	S-adenosylmethionine decarboxylase; Region: AdoMet_dc; pfam02675
742013017516	spermidine synthase; Provisional; Region: PRK00811
742013017517	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
742013017518	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
742013017519	phosphoglycolate phosphatase; Provisional; Region: PRK13222
742013017520	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
742013017521	motif II; other site
742013017522	Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835
742013017523	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
742013017524	HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304
742013017525	dimerization interface [polypeptide binding]; other site
742013017526	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
742013017527	dimer interface [polypeptide binding]; other site
742013017528	putative CheW interface [polypeptide binding]; other site
742013017529	Domain of unknown function (DUF3391); Region: DUF3391; pfam11871
742013017530	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
742013017531	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
742013017532	Zn2+ binding site [ion binding]; other site
742013017533	Mg2+ binding site [ion binding]; other site
742013017534	Response regulator receiver domain; Region: Response_reg; pfam00072
742013017535	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
742013017536	active site
742013017537	phosphorylation site [posttranslational modification]
742013017538	intermolecular recognition site; other site
742013017539	dimerization interface [polypeptide binding]; other site
742013017540	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
742013017541	Zn2+ binding site [ion binding]; other site
742013017542	Mg2+ binding site [ion binding]; other site
742013017543	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
742013017544	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
742013017545	substrate binding pocket [chemical binding]; other site
742013017546	membrane-bound complex binding site; other site
742013017547	hinge residues; other site
742013017548	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
742013017549	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
742013017550	putative active site [active]
742013017551	heme pocket [chemical binding]; other site
742013017552	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
742013017553	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
742013017554	putative active site [active]
742013017555	heme pocket [chemical binding]; other site
742013017556	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
742013017557	dimer interface [polypeptide binding]; other site
742013017558	phosphorylation site [posttranslational modification]
742013017559	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
742013017560	ATP binding site [chemical binding]; other site
742013017561	Mg2+ binding site [ion binding]; other site
742013017562	G-X-G motif; other site
742013017563	PAS fold; Region: PAS_4; pfam08448
742013017564	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
742013017565	putative active site [active]
742013017566	heme pocket [chemical binding]; other site
742013017567	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
742013017568	PAS domain; Region: PAS_9; pfam13426
742013017569	putative active site [active]
742013017570	heme pocket [chemical binding]; other site
742013017571	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
742013017572	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
742013017573	metal binding site [ion binding]; metal-binding site
742013017574	active site
742013017575	I-site; other site
742013017576	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
742013017577	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
742013017578	The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432
742013017579	dimerization interface [polypeptide binding]; other site
742013017580	substrate binding pocket [chemical binding]; other site
742013017581	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
742013017582	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
742013017583	NAD(P) binding site [chemical binding]; other site
742013017584	active site
742013017585	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
742013017586	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480
742013017587	Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290
742013017588	DctM-like transporters; Region: DctM; pfam06808
742013017589	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593
742013017590	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
742013017591	TPP-binding site [chemical binding]; other site
742013017592	dimer interface [polypeptide binding]; other site
742013017593	Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958
742013017594	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
742013017595	PYR/PP interface [polypeptide binding]; other site
742013017596	dimer interface [polypeptide binding]; other site
742013017597	TPP binding site [chemical binding]; other site
742013017598	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
742013017599	heavy metal response regulator; Region: cztR_silR_copR; TIGR01387
742013017600	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
742013017601	active site
742013017602	phosphorylation site [posttranslational modification]
742013017603	intermolecular recognition site; other site
742013017604	dimerization interface [polypeptide binding]; other site
742013017605	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
742013017606	DNA binding site [nucleotide binding]
742013017607	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
742013017608	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
742013017609	trimer interface [polypeptide binding]; other site
742013017610	eyelet of channel; other site
742013017611	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
742013017612	ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163
742013017613	substrate binding site [chemical binding]; other site
742013017614	hexamer interface [polypeptide binding]; other site
742013017615	metal binding site [ion binding]; metal-binding site
742013017616	CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461
742013017617	Site-specific recombinase; Region: SpecificRecomb; pfam10136
742013017618	gamma-glutamyl:cysteine ligase; Provisional; Region: PRK13516
742013017619	carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050
742013017620	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
742013017621	Protein of unknown function (DUF1446); Region: DUF1446; pfam07287
742013017622	DNA-binding transcriptional regulator CynR; Provisional; Region: PRK11242
742013017623	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
742013017624	TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440
742013017625	putative dimerization interface [polypeptide binding]; other site
742013017626	thiamine monophosphate kinase; Provisional; Region: PRK05731
742013017627	ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194
742013017628	ATP binding site [chemical binding]; other site
742013017629	dimerization interface [polypeptide binding]; other site
742013017630	conserved hypothetical protein; Region: TIGR02231
742013017631	N-terminal domain of unknown function (DUF4140); Region: DUF4140; pfam13600
742013017632	Domain of unknown function (DUF4139); Region: DUF4139; pfam13598
742013017633	Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971
742013017634	tetramer interfaces [polypeptide binding]; other site
742013017635	binuclear metal-binding site [ion binding]; other site
742013017636	Competence-damaged protein; Region: CinA; pfam02464
742013017637	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
742013017638	non-specific DNA binding site [nucleotide binding]; other site
742013017639	salt bridge; other site
742013017640	sequence-specific DNA binding site [nucleotide binding]; other site
742013017641	Uncharacterized protein family (UPF0149); Region: UPF0149; pfam03695
742013017642	SEC-C motif; Region: SEC-C; pfam02810
742013017643	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
742013017644	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
742013017645	active site
742013017646	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
742013017647	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08276
742013017648	Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929
742013017649	acyl-activating enzyme (AAE) consensus motif; other site
742013017650	putative active site [active]
742013017651	putative AMP binding site [chemical binding]; other site
742013017652	putative CoA binding site [chemical binding]; other site
742013017653	acetyl-CoA acetyltransferase; Provisional; Region: PRK07801
742013017654	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
742013017655	dimer interface [polypeptide binding]; other site
742013017656	active site
742013017657	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
742013017658	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
742013017659	NAD(P) binding site [chemical binding]; other site
742013017660	active site
742013017661	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
742013017662	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
742013017663	CoA-transferase family III; Region: CoA_transf_3; pfam02515
742013017664	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
742013017665	Transcriptional regulator [Transcription]; Region: IclR; COG1414
742013017666	IclR helix-turn-helix domain; Region: HTH_IclR; cl17605
742013017667	Transcriptional regulator [Transcription]; Region: IclR; COG1414
742013017668	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
742013017669	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
742013017670	Cytochrome P450; Region: p450; cl12078
742013017671	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
742013017672	Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal  ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185
742013017673	FMN-binding pocket [chemical binding]; other site
742013017674	flavin binding motif; other site
742013017675	phosphate binding motif [ion binding]; other site
742013017676	beta-alpha-beta structure motif; other site
742013017677	NAD binding pocket [chemical binding]; other site
742013017678	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
742013017679	catalytic loop [active]
742013017680	iron binding site [ion binding]; other site
742013017681	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
742013017682	Coenzyme A binding pocket [chemical binding]; other site
742013017683	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
742013017684	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
742013017685	DNA binding residues [nucleotide binding]
742013017686	Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712
742013017687	FecR protein; Region: FecR; pfam04773
742013017688	Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion transport and metabolism]; Region: FhuE; COG4773
742013017689	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
742013017690	N-terminal plug; other site
742013017691	ligand-binding site [chemical binding]; other site
742013017692	multidrug efflux system protein; Provisional; Region: PRK11431
742013017693	PIN domain; Region: PIN_3; pfam13470
742013017694	Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116
742013017695	THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715
742013017696	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
742013017697	ornithine cyclodeaminase; Validated; Region: PRK07589
742013017698	ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400
742013017699	Arginase family; Region: Arginase; cd09989
742013017700	active site
742013017701	Mn binding site [ion binding]; other site
742013017702	oligomer interface [polypeptide binding]; other site
742013017703	RNA 3'-terminal-phosphate cyclase; Provisional; Region: PRK04204
742013017704	RNA 3' phosphate cyclase domain (class II). These proteins function as RNA cyclase to catalyze the ATP-dependent conversion of 3'-phosphate to a 2'.3'-cyclic phosphodiester at the end of RNA molecule. A conserved catalytic histidine...; Region: RNA_Cyclase_Class_II; cd00874
742013017705	putative active site [active]
742013017706	adenylation catalytic residue [active]
742013017707	Predicted nucleotidyltransferase; Region: Nuc-transf; pfam10127
742013017708	hypothetical protein; Reviewed; Region: PRK09588
742013017709	Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139
742013017710	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
742013017711	Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403
742013017712	Sigma54-dependent transcription regulator containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: RtcR; COG4650
742013017713	Regulator of RNA terminal phosphate cyclase; Region: RtcR; pfam06956
742013017714	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
742013017715	Walker A motif; other site
742013017716	ATP binding site [chemical binding]; other site
742013017717	Walker B motif; other site
742013017718	arginine finger; other site
742013017719	RNA polymerase factor sigma-54; Reviewed; Region: PRK05932
742013017720	Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963
742013017721	Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552
742013017722	ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137
742013017723	ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218
742013017724	Walker A/P-loop; other site
742013017725	ATP binding site [chemical binding]; other site
742013017726	Q-loop/lid; other site
742013017727	ABC transporter signature motif; other site
742013017728	Walker B; other site
742013017729	D-loop; other site
742013017730	H-loop/switch region; other site
742013017731	lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002
742013017732	OstA-like protein; Region: OstA; pfam03968
742013017733	DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019
742013017734	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
742013017735	catalytic residues [active]
742013017736	hinge region; other site
742013017737	alpha helical domain; other site
742013017738	Sporulation related domain; Region: SPOR; pfam05036
742013017739	Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018
742013017740	Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016
742013017741	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
742013017742	active site
742013017743	HIGH motif; other site
742013017744	nucleotide binding site [chemical binding]; other site
742013017745	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
742013017746	KMSK motif region; other site
742013017747	Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956
742013017748	tRNA binding surface [nucleotide binding]; other site
742013017749	anticodon binding site; other site
742013017750	Predicted membrane protein (DUF2214); Region: DUF2214; cl01427
742013017751	Protein of unknown function (DUF3016); Region: DUF3016; pfam11454
742013017752	Transcriptional regulator [Transcription]; Region: LysR; COG0583
742013017753	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
742013017754	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
742013017755	putative effector binding pocket; other site
742013017756	dimerization interface [polypeptide binding]; other site
742013017757	malate synthase G; Provisional; Region: PRK02999
742013017758	active site
742013017759	Cysteine-rich CWC; Region: Cys_rich_CWC; pfam14375
742013017760	4-oxalocrotonate tautomerase; Provisional; Region: PRK00745
742013017761	active site 1 [active]
742013017762	dimer interface [polypeptide binding]; other site
742013017763	hexamer interface [polypeptide binding]; other site
742013017764	active site 2 [active]
742013017765	Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121
742013017766	Glutamine amidotransferases class-II (Gn-AT)_YafJ-type.  YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea.  YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908
742013017767	putative active site [active]
742013017768	putative dimer interface [polypeptide binding]; other site
742013017769	glutathione synthetase; Provisional; Region: PRK05246
742013017770	Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951
742013017771	Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955
742013017772	Benzoate membrane transport protein; Region: BenE; pfam03594
742013017773	benzoate transporter; Region: benE; TIGR00843
742013017774	K+ transporter [Inorganic ion transport and metabolism]; Region: Kup; COG3158
742013017775	potassium uptake protein; Region: kup; TIGR00794
742013017776	glutamate--cysteine ligase, T. ferrooxidans family; Region: gshA_ferroox; TIGR02049
742013017777	Glutamate-cysteine ligase; Region: GshA; pfam08886
742013017778	Cation transport protein; Region: TrkH; cl17365
742013017779	potassium uptake protein, TrkH family; Region: 2a38; TIGR00933
742013017780	potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496
742013017781	TrkA-N domain; Region: TrkA_N; pfam02254
742013017782	TrkA-C domain; Region: TrkA_C; pfam02080
742013017783	TrkA-N domain; Region: TrkA_N; pfam02254
742013017784	TrkA-C domain; Region: TrkA_C; pfam02080
742013017785	gamma-glutamyl phosphate reductase; Region: proA; TIGR00407
742013017786	Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079
742013017787	putative catalytic cysteine [active]
742013017788	DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574
742013017789	DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144
742013017790	Lipopolysaccharide-assembly; Region: LptE; cl01125
742013017791	leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
742013017792	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
742013017793	HIGH motif; other site
742013017794	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
742013017795	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
742013017796	active site
742013017797	KMSKS motif; other site
742013017798	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
742013017799	tRNA binding surface [nucleotide binding]; other site
742013017800	Mechanosensitive ion channel; Region: MS_channel; pfam00924
742013017801	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
742013017802	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
742013017803	TolR protein; Region: tolR; TIGR02801
742013017804	Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811
742013017805	dihydrodipicolinate reductase; Provisional; Region: PRK00048
742013017806	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
742013017807	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
742013017808	Outer membrane lipoprotein OmlA (small protein A) [Cell envelope biogenesis, outer membrane]; Region: OlmA; COG2913
742013017809	SmpA / OmlA family; Region: SmpA_OmlA; cl17115
742013017810	SmpA / OmlA family; Region: SmpA_OmlA; pfam04355
742013017811	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
742013017812	metal binding site 2 [ion binding]; metal-binding site
742013017813	putative DNA binding helix; other site
742013017814	metal binding site 1 [ion binding]; metal-binding site
742013017815	dimer interface [polypeptide binding]; other site
742013017816	structural Zn2+ binding site [ion binding]; other site
742013017817	Protein of unknown function (DUF1800); Region: DUF1800; pfam08811
742013017818	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4102
742013017819	RNA polymerase sigma-70 factor, TIGR02957 family; Region: SigX4
742013017820	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
742013017821	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
742013017822	DNA binding residues [nucleotide binding]
742013017823	Contains a crystal structure of the Nudix hydrolase from Nitrosomonas europaea, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_2; cd03675
742013017824	nudix motif; other site
742013017825	Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437
742013017826	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
742013017827	active site
742013017828	phosphorylation site [posttranslational modification]
742013017829	intermolecular recognition site; other site
742013017830	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
742013017831	Zn2+ binding site [ion binding]; other site
742013017832	Mg2+ binding site [ion binding]; other site
742013017833	Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707
742013017834	Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707
742013017835	PAS domain S-box; Region: sensory_box; TIGR00229
742013017836	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
742013017837	putative active site [active]
742013017838	heme pocket [chemical binding]; other site
742013017839	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
742013017840	PAS fold; Region: PAS_3; pfam08447
742013017841	putative active site [active]
742013017842	heme pocket [chemical binding]; other site
742013017843	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
742013017844	PAS domain; Region: PAS_9; pfam13426
742013017845	putative active site [active]
742013017846	heme pocket [chemical binding]; other site
742013017847	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
742013017848	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
742013017849	dimer interface [polypeptide binding]; other site
742013017850	phosphorylation site [posttranslational modification]
742013017851	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
742013017852	ATP binding site [chemical binding]; other site
742013017853	Mg2+ binding site [ion binding]; other site
742013017854	G-X-G motif; other site
742013017855	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
742013017856	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
742013017857	active site
742013017858	phosphorylation site [posttranslational modification]
742013017859	intermolecular recognition site; other site
742013017860	dimerization interface [polypeptide binding]; other site
742013017861	Predicted membrane protein (DUF2061); Region: DUF2061; cl01257
742013017862	Transcriptional regulator [Transcription]; Region: LysR; COG0583
742013017863	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
742013017864	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
742013017865	dimerization interface [polypeptide binding]; other site
742013017866	beta alanine--pyruvate transaminase; Provisional; Region: PRK09221
742013017867	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
742013017868	inhibitor-cofactor binding pocket; inhibition site
742013017869	pyridoxal 5'-phosphate binding site [chemical binding]; other site
742013017870	catalytic residue [active]
742013017871	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
742013017872	Transcriptional regulators [Transcription]; Region: FadR; COG2186
742013017873	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
742013017874	DNA-binding site [nucleotide binding]; DNA binding site
742013017875	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
742013017876	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
742013017877	Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327
742013017878	putative ligand binding site [chemical binding]; other site
742013017879	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
742013017880	TM-ABC transporter signature motif; other site
742013017881	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
742013017882	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
742013017883	TM-ABC transporter signature motif; other site
742013017884	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
742013017885	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
742013017886	Walker A/P-loop; other site
742013017887	ATP binding site [chemical binding]; other site
742013017888	Q-loop/lid; other site
742013017889	ABC transporter signature motif; other site
742013017890	Walker B; other site
742013017891	D-loop; other site
742013017892	H-loop/switch region; other site
742013017893	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
742013017894	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
742013017895	Walker A/P-loop; other site
742013017896	ATP binding site [chemical binding]; other site
742013017897	Q-loop/lid; other site
742013017898	ABC transporter signature motif; other site
742013017899	Walker B; other site
742013017900	D-loop; other site
742013017901	H-loop/switch region; other site
742013017902	allantoate amidohydrolase; Reviewed; Region: PRK12893
742013017903	M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884
742013017904	active site
742013017905	metal binding site [ion binding]; metal-binding site
742013017906	dimer interface [polypeptide binding]; other site
742013017907	Uncharacterized conserved protein [Function unknown]; Region: COG5476
742013017908	Protein of unknown function (DUF1485); Region: DUF1485; pfam07364
742013017909	MlrC C-terminus; Region: MlrC_C; pfam07171
742013017910	Malate dehydrogenase enzyme; Region: Malate_DH; pfam12434
742013017911	malic enzyme; Reviewed; Region: PRK12862
742013017912	Malic enzyme, N-terminal domain; Region: malic; pfam00390
742013017913	Malic enzyme, NAD binding domain; Region: Malic_M; smart00919
742013017914	NAD(P) binding pocket [chemical binding]; other site
742013017915	Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280
742013017916	RNase_Sa. Ribonucleases first isolated from Streptomyces aureofaciens. In general, ribonucleases cleave phosphodiester bonds in RNA and are essential  for both non-specific RNA degradation and for numerous forms of RNA processing. RNAse Sa is a guanylate...; Region: RNase_Sa; cd00607
742013017917	active site
742013017918	barstar interaction site; other site
742013017919	Barstar_evA4336-like contains uncharacterized sequences similar to the uncharacterized, predicted RNAase inhibitor evA4336 found in Azoarcus sp. EvN1. This is a subfamily of the Barstar family of RNAase inhibitors. Barstar is an intracellular inhibitor...; Region: Barstar_evA4336-like; cd05141
742013017920	putative RNAase interaction site [polypeptide binding]; other site
742013017921	16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274
742013017922	Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030
742013017923	peptidyl-prolyl cis-trans isomerase SurA; Provisional; Region: PRK10770
742013017924	SurA N-terminal domain; Region: SurA_N; pfam09312
742013017925	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
742013017926	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
742013017927	Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452
742013017928	Organic solvent tolerance protein; Region: OstA_C; pfam04453
742013017929	Predicted phosphotransferase related to Ser/Thr protein kinases [General function prediction only]; Region: COG3178
742013017930	Phosphotransferase enzyme family; Region: APH; pfam01636
742013017931	16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713
742013017932	RNA methyltransferase, RsmE family; Region: TIGR00046
742013017933	Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
742013017934	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
742013017935	hypothetical protein; Provisional; Region: PRK07907
742013017936	Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_5; cd05682
742013017937	metal binding site [ion binding]; metal-binding site
742013017938	putative dimer interface [polypeptide binding]; other site
742013017939	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
742013017940	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
742013017941	DNA binding residues [nucleotide binding]
742013017942	Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249
742013017943	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
742013017944	glycerophosphodiester phosphodiesterase; Provisional; Region: glpQ; PRK11143
742013017945	Glycerophosphodiester phosphodiesterase domain of Streptomycin coelicolor (GlpQ1) and similar proteins; Region: GDPD_ScGlpQ1_like; cd08602
742013017946	putative active site [active]
742013017947	catalytic site [active]
742013017948	putative metal binding site [ion binding]; other site
742013017949	Methyltransferase domain; Region: Methyltransf_23; pfam13489
742013017950	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
742013017951	S-adenosylmethionine binding site [chemical binding]; other site
742013017952	homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175
742013017953	homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392
742013017954	Predicted membrane protein [Function unknown]; Region: COG2119
742013017955	Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169
742013017956	Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169
742013017957	RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399
742013017958	RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724
742013017959	RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399
742013017960	short chain dehydrogenase; Provisional; Region: PRK07024
742013017961	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
742013017962	NAD(P) binding site [chemical binding]; other site
742013017963	active site
742013017964	Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835
742013017965	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3117; cl01200
742013017966	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
742013017967	active site
742013017968	motif I; other site
742013017969	motif II; other site
742013017970	D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892
742013017971	KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014
742013017972	putative active site [active]
742013017973	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein.  These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604
742013017974	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
742013017975	active site
742013017976	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
742013017977	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
742013017978	ligand binding site [chemical binding]; other site
742013017979	flexible hinge region; other site
742013017980	tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291
742013017981	GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396
742013017982	trmE is a tRNA modification GTPase; Region: trmE; cd04164
742013017983	G1 box; other site
742013017984	GTP/Mg2+ binding site [chemical binding]; other site
742013017985	Switch I region; other site
742013017986	G2 box; other site
742013017987	Switch II region; other site
742013017988	G3 box; other site
742013017989	G4 box; other site
742013017990	G5 box; other site
742013017991	Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631
742013017992	membrane protein insertase; Provisional; Region: PRK01318
742013017993	membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592
742013017994	hypothetical protein; Provisional; Region: PRK14389
742013017995	Ribonuclease P; Region: Ribonuclease_P; cl00457
742013017996	50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399