-- dump date   	20140619_060209
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
546414000001	chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149
546414000002	DnaA N-terminal domain; Region: DnaA_N; pfam11638
546414000003	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
546414000004	Walker A motif; other site
546414000005	ATP binding site [chemical binding]; other site
546414000006	Walker B motif; other site
546414000007	arginine finger; other site
546414000008	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
546414000009	DnaA box-binding interface [nucleotide binding]; other site
546414000010	DNA polymerase III subunit beta; Provisional; Region: PRK14945
546414000011	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
546414000012	putative DNA binding surface [nucleotide binding]; other site
546414000013	dimer interface [polypeptide binding]; other site
546414000014	beta-clamp/clamp loader binding surface; other site
546414000015	beta-clamp/translesion DNA polymerase binding surface; other site
546414000016	enolase; Provisional; Region: eno; PRK00077
546414000017	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
546414000018	dimer interface [polypeptide binding]; other site
546414000019	metal binding site [ion binding]; metal-binding site
546414000020	substrate binding pocket [chemical binding]; other site
546414000021	Pyruvate kinase [Carbohydrate transport and metabolism]; Region: PykF; COG0469
546414000022	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
546414000023	domain interfaces; other site
546414000024	active site
546414000025	tyrosyl-tRNA synthetase; Validated; Region: PRK05912
546414000026	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
546414000027	active site
546414000028	HIGH motif; other site
546414000029	dimer interface [polypeptide binding]; other site
546414000030	KMSKS motif; other site
546414000031	S4 RNA-binding domain; Region: S4; smart00363
546414000032	RNA binding surface [nucleotide binding]; other site
546414000033	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258
546414000034	MOSC domain; Region: MOSC; pfam03473
546414000035	Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384
546414000036	Family of unknown function (DUF633); Region: DUF633; pfam04816
546414000037	Domain of unknown function (DUF3552); Region: DUF3552; pfam12072
546414000038	Predicted RNA-binding protein (contains KH domains) [General function prediction only]; Region: COG1094
546414000039	KH domain; Region: KH_1; pfam00013
546414000040	Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418
546414000041	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
546414000042	Zn2+ binding site [ion binding]; other site
546414000043	Mg2+ binding site [ion binding]; other site
546414000044	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
546414000045	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
546414000046	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
546414000047	30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391
546414000048	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
546414000049	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
546414000050	dimer interface [polypeptide binding]; other site
546414000051	ssDNA binding site [nucleotide binding]; other site
546414000052	tetramer (dimer of dimers) interface [polypeptide binding]; other site
546414000053	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
546414000054	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
546414000055	dimer interface [polypeptide binding]; other site
546414000056	ssDNA binding site [nucleotide binding]; other site
546414000057	tetramer (dimer of dimers) interface [polypeptide binding]; other site
546414000058	Ribosomal protein S6 [Translation, ribosomal structure and biogenesis]; Region: RpsF; COG0360
546414000059	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
546414000060	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
546414000061	active site
546414000062	ATP binding site [chemical binding]; other site
546414000063	substrate binding site [chemical binding]; other site
546414000064	activation loop (A-loop); other site
546414000065	peptide chain release factor 2; Validated; Region: prfB; PRK00578
546414000066	PCRF domain; Region: PCRF; pfam03462
546414000067	RF-1 domain; Region: RF-1; pfam00472
546414000068	CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588
546414000069	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
546414000070	dimer interface [polypeptide binding]; other site
546414000071	conserved gate region; other site
546414000072	ABC-ATPase subunit interface; other site
546414000073	ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125
546414000074	ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295
546414000075	Walker A/P-loop; other site
546414000076	ATP binding site [chemical binding]; other site
546414000077	Q-loop/lid; other site
546414000078	ABC transporter signature motif; other site
546414000079	Walker B; other site
546414000080	D-loop; other site
546414000081	H-loop/switch region; other site
546414000082	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
546414000083	dimer interface [polypeptide binding]; other site
546414000084	conserved gate region; other site
546414000085	ABC-ATPase subunit interface; other site
546414000086	Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732
546414000087	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
546414000088	IHF - DNA interface [nucleotide binding]; other site
546414000089	IHF dimer interface [polypeptide binding]; other site
546414000090	molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690
546414000091	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
546414000092	ATP binding site [chemical binding]; other site
546414000093	substrate interface [chemical binding]; other site
546414000094	membrane protein; Provisional; Region: PRK14401
546414000095	3-polyprenyl-4-hydroxybenzoate decarboxylase [Coenzyme metabolism]; Region: UbiX; COG0163
546414000096	Flavoprotein; Region: Flavoprotein; pfam02441
546414000097	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
546414000098	substrate binding site; other site
546414000099	dimer interface; other site
546414000100	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK14612
546414000101	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
546414000102	Protein related to penicillin acylase [General function prediction only]; Region: COG2366
546414000103	The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid.  N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467
546414000104	Penicillin G acylase (PGA) belongs to a family of beta-lactam acylases that includes cephalosporin acylase (CA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_PGA_like; cd03747
546414000105	active site
546414000106	hypothetical protein; Validated; Region: PRK00068
546414000107	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
546414000108	active site
546414000109	metal binding site [ion binding]; metal-binding site
546414000110	Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1),  6-pyrovoyl...; Region: TFold; cl00263
546414000111	6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242
546414000112	active site
546414000113	Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602
546414000114	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
546414000115	FeS/SAM binding site; other site
546414000116	ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995
546414000117	Ligand Binding Site [chemical binding]; other site
546414000118	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
546414000119	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
546414000120	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
546414000121	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
546414000122	e3 binding domain; Region: E3_binding; pfam02817
546414000123	Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334
546414000124	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
546414000125	NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226
546414000126	NAD(P) binding pocket [chemical binding]; other site
546414000127	Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572
546414000128	Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023
546414000129	ATP-binding site [chemical binding]; other site
546414000130	Sugar specificity; other site
546414000131	Pyrimidine base specificity; other site
546414000132	Polysaccharide pyruvyl transferase family protein [Cell wall/membrane/envelope biogenesis]; Region: WcaK; COG2327
546414000133	Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; cl09156
546414000134	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
546414000135	CoenzymeA binding site [chemical binding]; other site
546414000136	subunit interaction site [polypeptide binding]; other site
546414000137	PHB binding site; other site
546414000138	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
546414000139	CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492
546414000140	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683
546414000141	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
546414000142	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
546414000143	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
546414000144	Walker A/P-loop; other site
546414000145	ATP binding site [chemical binding]; other site
546414000146	Q-loop/lid; other site
546414000147	ABC transporter signature motif; other site
546414000148	Walker B; other site
546414000149	D-loop; other site
546414000150	H-loop/switch region; other site
546414000151	Beta-mannanase [Carbohydrate transport and metabolism]; Region: ManB; COG4124
546414000152	primosomal protein N' Region: priA; TIGR00595
546414000153	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
546414000154	EamA-like transporter family; Region: EamA; pfam00892
546414000155	Roadblock/LC7 domain; Region: Robl_LC7; smart00960
546414000156	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
546414000157	PA: Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain; Region: PA; cl08238
546414000158	PA/protease or protease-like domain interface [polypeptide binding]; other site
546414000159	M28 Zn-peptidases include aminopeptidases and carboxypeptidases; Region: M28; cd02690
546414000160	Peptidase family M28; Region: Peptidase_M28; pfam04389
546414000161	metal binding site [ion binding]; metal-binding site
546414000162	Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046
546414000163	beta-galactosidase; Region: BGL; TIGR03356
546414000164	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
546414000165	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
546414000166	dimer interface [polypeptide binding]; other site
546414000167	conserved gate region; other site
546414000168	putative PBP binding loops; other site
546414000169	ABC-ATPase subunit interface; other site
546414000170	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
546414000171	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
546414000172	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
546414000173	putative PBP binding loops; other site
546414000174	dimer interface [polypeptide binding]; other site
546414000175	ABC-ATPase subunit interface; other site
546414000176	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
546414000177	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
546414000178	Transcriptional regulators [Transcription]; Region: PurR; COG1609
546414000179	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
546414000180	DNA binding site [nucleotide binding]
546414000181	domain linker motif; other site
546414000182	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
546414000183	Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021
546414000184	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
546414000185	TPP-binding site [chemical binding]; other site
546414000186	dimer interface [polypeptide binding]; other site
546414000187	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
546414000188	PYR/PP interface [polypeptide binding]; other site
546414000189	dimer interface [polypeptide binding]; other site
546414000190	TPP binding site [chemical binding]; other site
546414000191	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
546414000192	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
546414000193	Coenzyme A binding pocket [chemical binding]; other site
546414000194	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4102
546414000195	Protein of unknown function (DUF1800); Region: DUF1800; pfam08811
546414000196	RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652
546414000197	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
546414000198	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
546414000199	DNA binding residues [nucleotide binding]
546414000200	Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321
546414000201	Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325
546414000202	Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742
546414000203	This entry represents the core domain of the ferrous iron (Fe2+) transport protein FeoA found in bacteria; Region: FeoA; smart00899
546414000204	DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024
546414000205	Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761
546414000206	catalytic residues [active]
546414000207	Bacterial SH3 domain; Region: SH3_3; pfam08239
546414000208	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
546414000209	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
546414000210	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
546414000211	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
546414000212	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
546414000213	ATP-grasp domain; Region: ATP-grasp_4; cl17255
546414000214	argininosuccinate synthase; Provisional; Region: PRK13820
546414000215	Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate .  In...; Region: Argininosuccinate_Synthase; cd01999
546414000216	ANP binding site [chemical binding]; other site
546414000217	Substrate Binding Site II [chemical binding]; other site
546414000218	Substrate Binding Site I [chemical binding]; other site
546414000219	DinB superfamily; Region: DinB_2; pfam12867
546414000220	metal-dependent hydrolase; Provisional; Region: PRK13291
546414000221	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
546414000222	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
546414000223	Coenzyme A binding pocket [chemical binding]; other site
546414000224	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
546414000225	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
546414000226	Coenzyme A binding pocket [chemical binding]; other site
546414000227	argininosuccinate lyase; Provisional; Region: PRK00855
546414000228	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
546414000229	active sites [active]
546414000230	tetramer interface [polypeptide binding]; other site
546414000231	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
546414000232	Coenzyme A binding pocket [chemical binding]; other site
546414000233	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
546414000234	Coenzyme A binding pocket [chemical binding]; other site
546414000235	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
546414000236	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
546414000237	Coenzyme A binding pocket [chemical binding]; other site
546414000238	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
546414000239	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097
546414000240	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
546414000241	catalytic site [active]
546414000242	subunit interface [polypeptide binding]; other site
546414000243	Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027
546414000244	ligand binding site [chemical binding]; other site
546414000245	active site
546414000246	UGI interface [polypeptide binding]; other site
546414000247	catalytic site [active]
546414000248	Topoisomerase IB [DNA replication, recombination, and repair]; Region: COG3569
546414000249	DNA topoisomerase IB, C-terminal catalytic domain. Topoisomerase I promotes the relaxation of both positive and negative DNA superhelical tension by introducing a transient single-stranded break in duplex DNA. This function is vital for the processes of...; Region: Topo_IB_C; cd00659
546414000250	active site
546414000251	DNA binding site [nucleotide binding]
546414000252	Int/Topo IB signature motif; other site
546414000253	catalytic residues [active]
546414000254	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
546414000255	putative active site [active]
546414000256	catalytic residue [active]
546414000257	Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363
546414000258	M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656
546414000259	oligomer interface [polypeptide binding]; other site
546414000260	active site
546414000261	metal binding site [ion binding]; metal-binding site
546414000262	Domain of unknown function (DUF4126); Region: DUF4126; pfam13548
546414000263	Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347
546414000264	Nitrogen regulatory protein P-II; Region: P-II; smart00938
546414000265	Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004
546414000266	Archaeal/vacuolar-type H+-ATPase subunit I [Energy production and conversion]; Region: NtpI; COG1269
546414000267	ATP synthase subunit C; Region: ATP-synt_C; cl00466
546414000268	Archaeal/vacuolar-type H+-ATPase subunit E [Energy production and conversion]; Region: NtpE; COG1390
546414000269	Archaeal/vacuolar-type H+-ATPase subunit C [Energy production and conversion]; Region: NtpC; COG1527
546414000270	V-type ATP synthase subunit C; Provisional; Region: PRK01198; cl00660
546414000271	Archaeal/vacuolar-type H+-ATPase subunit F [Energy production and conversion]; Region: NtpG; COG1436
546414000272	V-type ATP synthase subunit A; Provisional; Region: PRK04192
546414000273	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
546414000274	V/A-type ATP synthase catalytic subunit A. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction.  The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_A; cd01134
546414000275	Walker A motif/ATP binding site; other site
546414000276	Walker B motif; other site
546414000277	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
546414000278	V-type ATP synthase subunit B; Provisional; Region: PRK04196
546414000279	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
546414000280	V/A-type ATP synthase (non-catalytic) subunit B. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction. The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_B; cd01135
546414000281	Walker A motif homologous position; other site
546414000282	Walker B motif; other site
546414000283	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
546414000284	Archaeal/vacuolar-type H+-ATPase subunit D [Energy production and conversion]; Region: NtpD; COG1394
546414000285	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4339
546414000286	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
546414000287	ROK family; Region: ROK; pfam00480
546414000288	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
546414000289	active site
546414000290	Septum formation initiator; Region: DivIC; cl17659
546414000291	Thymidine phosphorylase [Nucleotide transport and metabolism]; Region: DeoA; COG0213
546414000292	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
546414000293	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
546414000294	Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831
546414000295	Predicted transcriptional regulator [Transcription]; Region: COG2378
546414000296	HTH domain; Region: HTH_11; pfam08279
546414000297	WYL domain; Region: WYL; pfam13280
546414000298	DinB family; Region: DinB; cl17821
546414000299	DinB superfamily; Region: DinB_2; pfam12867
546414000300	DinB family; Region: DinB; cl17821
546414000301	DinB superfamily; Region: DinB_2; pfam12867
546414000302	Uncharacterized conserved protein [Function unknown]; Region: COG3603
546414000303	Family description; Region: ACT_7; pfam13840
546414000304	FtsH Extracellular; Region: FtsH_ext; pfam06480
546414000305	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
546414000306	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
546414000307	Walker A motif; other site
546414000308	ATP binding site [chemical binding]; other site
546414000309	Walker B motif; other site
546414000310	arginine finger; other site
546414000311	Peptidase family M41; Region: Peptidase_M41; pfam01434
546414000312	thioredoxin 2; Provisional; Region: PRK10996
546414000313	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
546414000314	catalytic residues [active]
546414000315	glutaminyl-tRNA synthetase/YqeY domain fusion protein; Provisional; Region: PRK14703
546414000316	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
546414000317	active site
546414000318	HIGH motif; other site
546414000319	nucleotide binding site [chemical binding]; other site
546414000320	catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807
546414000321	KMSKS motif; other site
546414000322	tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950
546414000323	GatB domain; Region: GatB_Yqey; smart00845
546414000324	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
546414000325	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
546414000326	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
546414000327	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
546414000328	SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974
546414000329	non-specific DNA binding site [nucleotide binding]; other site
546414000330	salt bridge; other site
546414000331	sequence-specific DNA binding site [nucleotide binding]; other site
546414000332	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
546414000333	Catalytic site [active]
546414000334	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661
546414000335	putative active site pocket [active]
546414000336	dimerization interface [polypeptide binding]; other site
546414000337	putative catalytic residue [active]
546414000338	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
546414000339	16S/18S rRNA binding site [nucleotide binding]; other site
546414000340	S13e-L30e interaction site [polypeptide binding]; other site
546414000341	25S rRNA binding site [nucleotide binding]; other site
546414000342	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378
546414000343	active site clefts [active]
546414000344	zinc binding site [ion binding]; other site
546414000345	dimer interface [polypeptide binding]; other site
546414000346	Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073
546414000347	Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309
546414000348	Response regulator receiver domain; Region: Response_reg; pfam00072
546414000349	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
546414000350	active site
546414000351	phosphorylation site [posttranslational modification]
546414000352	intermolecular recognition site; other site
546414000353	dimerization interface [polypeptide binding]; other site
546414000354	PAS domain; Region: PAS_9; pfam13426
546414000355	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
546414000356	putative active site [active]
546414000357	heme pocket [chemical binding]; other site
546414000358	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
546414000359	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
546414000360	metal binding site [ion binding]; metal-binding site
546414000361	active site
546414000362	I-site; other site
546414000363	Polysulfide-sulfurtransferase - Rhodanese Homology Domain. This domain is believed to serve as a polysulfide binding and transferase domain in anaerobic gram-negative bacteria, functioning in oxidative phosphorylation with polysulfide-sulfur as a...; Region: Polysulfide_ST; cd01447
546414000364	active site
546414000365	catalytic residue [active]
546414000366	Cupin domain; Region: Cupin_2; pfam07883
546414000367	Cupin domain; Region: Cupin_2; pfam07883
546414000368	Hypothetical protein TTHB210, a sigma(E)-regulated gene product found in Thermus thermophilus, and similar proteins; Region: TTHB210-like; cd11669
546414000369	oligomer interface [polypeptide binding]; other site
546414000370	homoserine kinase; Provisional; Region: PRK01212
546414000371	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
546414000372	threonine synthase; Reviewed; Region: PRK06721
546414000373	Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of  threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563
546414000374	homodimer interface [polypeptide binding]; other site
546414000375	pyridoxal 5'-phosphate binding site [chemical binding]; other site
546414000376	catalytic residue [active]
546414000377	Predicted membrane protein [Function unknown]; Region: COG2261
546414000378	50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359
546414000379	lipoprotein signal peptidase; Provisional; Region: PRK14777
546414000380	S-ribosylhomocysteinase; Provisional; Region: PRK02260
546414000381	polyphosphate:nucleotide phosphotransferase, PPK2 family; Region: PPK2_rel_1; TIGR03709
546414000382	Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416
546414000383	citrylCoA binding site [chemical binding]; other site
546414000384	oxalacetate binding site [chemical binding]; other site
546414000385	coenzyme A binding site [chemical binding]; other site
546414000386	catalytic triad [active]
546414000387	Predicted permeases [General function prediction only]; Region: COG0679
546414000388	50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286
546414000389	Predicted membrane protein [Function unknown]; Region: COG2860
546414000390	UPF0126 domain; Region: UPF0126; pfam03458
546414000391	UPF0126 domain; Region: UPF0126; pfam03458
546414000392	Transcriptional regulators [Transcription]; Region: PurR; COG1609
546414000393	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
546414000394	DNA binding site [nucleotide binding]
546414000395	domain linker motif; other site
546414000396	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
546414000397	UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087
546414000398	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
546414000399	NAD binding site [chemical binding]; other site
546414000400	homodimer interface [polypeptide binding]; other site
546414000401	active site
546414000402	substrate binding site [chemical binding]; other site
546414000403	hypothetical protein; Provisional; Region: PRK06446
546414000404	Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_4; cd05681
546414000405	metal binding site [ion binding]; metal-binding site
546414000406	dimer interface [polypeptide binding]; other site
546414000407	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
546414000408	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
546414000409	classical (c) SDRs; Region: SDR_c; cd05233
546414000410	NAD(P) binding site [chemical binding]; other site
546414000411	active site
546414000412	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
546414000413	A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066
546414000414	active site
546414000415	menaquinone biosynthesis decarboxylase, SCO4490 family; Region: mena_SCO4490; TIGR03701
546414000416	3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; cl00311
546414000417	multidrug efflux protein NorA; Provisional; Region: PRK00187
546414000418	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131
546414000419	cation binding site [ion binding]; other site
546414000420	putative 4-hydroxybenzoate polyprenyltransferase; Region: ubiA_other; TIGR01475
546414000421	UbiA prenyltransferase family; Region: UbiA; pfam01040
546414000422	Alkyl sulfatase and related hydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2015
546414000423	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
546414000424	cyclase homology domain; Region: CHD; cd07302
546414000425	nucleotidyl binding site; other site
546414000426	metal binding site [ion binding]; metal-binding site
546414000427	dimer interface [polypeptide binding]; other site
546414000428	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
546414000429	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
546414000430	active site
546414000431	phosphorylation site [posttranslational modification]
546414000432	intermolecular recognition site; other site
546414000433	dimerization interface [polypeptide binding]; other site
546414000434	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
546414000435	DNA binding site [nucleotide binding]
546414000436	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
546414000437	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
546414000438	dimerization interface [polypeptide binding]; other site
546414000439	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
546414000440	dimer interface [polypeptide binding]; other site
546414000441	phosphorylation site [posttranslational modification]
546414000442	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
546414000443	ATP binding site [chemical binding]; other site
546414000444	Mg2+ binding site [ion binding]; other site
546414000445	G-X-G motif; other site
546414000446	Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316
546414000447	arginine repressor; Region: argR_whole; TIGR01529
546414000448	Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863
546414000449	bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579
546414000450	Flavoprotein; Region: Flavoprotein; pfam02441
546414000451	DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127
546414000452	porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072
546414000453	Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708
546414000454	domain interfaces; other site
546414000455	active site
546414000456	Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964
546414000457	active site
546414000458	homotetramer interface [polypeptide binding]; other site
546414000459	homodimer interface [polypeptide binding]; other site
546414000460	Transcriptional regulators [Transcription]; Region: MarR; COG1846
546414000461	MarR family; Region: MarR_2; cl17246
546414000462	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
546414000463	Cytochrome P450; Region: p450; cl12078
546414000464	putative acyltransferase; Provisional; Region: PRK05790
546414000465	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
546414000466	dimer interface [polypeptide binding]; other site
546414000467	active site
546414000468	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2350
546414000469	3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808
546414000470	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
546414000471	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
546414000472	DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14963
546414000473	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
546414000474	Walker A motif; other site
546414000475	ATP binding site [chemical binding]; other site
546414000476	Walker B motif; other site
546414000477	arginine finger; other site
546414000478	Uncharacterized BCR, COG1649; Region: DUF187; pfam02638
546414000479	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
546414000480	Flavin reductase like domain; Region: Flavin_Reduct; smart00903
546414000481	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
546414000482	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cd00838
546414000483	active site
546414000484	metal binding site [ion binding]; metal-binding site
546414000485	N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328
546414000486	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
546414000487	S-adenosylmethionine binding site [chemical binding]; other site
546414000488	Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847
546414000489	jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation.  The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414
546414000490	G-X-X-G motif; other site
546414000491	R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644
546414000492	RxxxH motif; other site
546414000493	Low molecular weight phosphatase family; Region: LMWPc; cd00115
546414000494	Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451
546414000495	active site
546414000496	acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724
546414000497	acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198
546414000498	acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654
546414000499	zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240
546414000500	Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763
546414000501	active site
546414000502	membrane glycoprotein; Provisional; Region: PHA03332
546414000503	CutA1 divalent ion tolerance protein; Region: CutA1; pfam03091
546414000504	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
546414000505	Peptidase S8 family domain in Subtilisin-like proteins; Region: Peptidases_S8_Subtilisin_like; cd07473
546414000506	catalytic triad [active]
546414000507	putative active site [active]
546414000508	Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404
546414000509	Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922
546414000510	Peptidase S8 family domain in ProteinaseK-like proteins; Region: Peptidases_S8_PCSK9_ProteinaseK_like; cd04077
546414000511	calcium binding site 2 [ion binding]; other site
546414000512	active site
546414000513	catalytic triad [active]
546414000514	calcium binding site 1 [ion binding]; other site
546414000515	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
546414000516	active site
546414000517	catalytic residues [active]
546414000518	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
546414000519	active site
546414000520	catalytic residues [active]
546414000521	Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177
546414000522	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
546414000523	minor groove reading motif; other site
546414000524	helix-hairpin-helix signature motif; other site
546414000525	substrate binding pocket [chemical binding]; other site
546414000526	active site
546414000527	iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525
546414000528	H+ Antiporter protein; Region: 2A0121; TIGR00900
546414000529	Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579
546414000530	Putative zinc ribbon domain; Region: DUF164; pfam02591
546414000531	Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248
546414000532	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
546414000533	L-Aminopeptidase D-amidase/D-esterase (DmpA) family; DmpA catalyzes the release of N-terminal D and L amino acids from peptide susbtrates. DmpA is synthesized as a single polypeptide precursor, which is autocatalytically cleaved to the active...; Region: DmpA; cd02253
546414000534	homodimer interface [polypeptide binding]; other site
546414000535	homotetramer interface [polypeptide binding]; other site
546414000536	active site pocket [active]
546414000537	cleavage site
546414000538	pyridoxamine kinase; Validated; Region: PRK05756
546414000539	Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate  (PLP), by catalyzing the phosphorylation of the precursor vitamin B6  in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173
546414000540	dimer interface [polypeptide binding]; other site
546414000541	pyridoxal binding site [chemical binding]; other site
546414000542	ATP binding site [chemical binding]; other site
546414000543	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
546414000544	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
546414000545	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
546414000546	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
546414000547	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
546414000548	active site
546414000549	phosphorylation site [posttranslational modification]
546414000550	intermolecular recognition site; other site
546414000551	dimerization interface [polypeptide binding]; other site
546414000552	CHASE3 domain; Region: CHASE3; cl05000
546414000553	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
546414000554	dimerization interface [polypeptide binding]; other site
546414000555	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
546414000556	dimer interface [polypeptide binding]; other site
546414000557	phosphorylation site [posttranslational modification]
546414000558	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
546414000559	ATP binding site [chemical binding]; other site
546414000560	Mg2+ binding site [ion binding]; other site
546414000561	G-X-G motif; other site
546414000562	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
546414000563	substrate binding site [chemical binding]; other site
546414000564	oxyanion hole (OAH) forming residues; other site
546414000565	trimer interface [polypeptide binding]; other site
546414000566	short chain dehydrogenase; Provisional; Region: PRK07576
546414000567	Trans-2-enoyl-CoA reductase (TER) and 2,4-dienoyl-CoA reductase (DECR), atypical (a) SDR; Region: TER_DECR_SDR_a; cd05369
546414000568	NAD(P) binding site [chemical binding]; other site
546414000569	substrate binding site [chemical binding]; other site
546414000570	homotetramer interface [polypeptide binding]; other site
546414000571	active site
546414000572	homodimer interface [polypeptide binding]; other site
546414000573	alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403
546414000574	Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333
546414000575	Ca binding site [ion binding]; other site
546414000576	active site
546414000577	catalytic site [active]
546414000578	Predicted membrane protein [Function unknown]; Region: COG2311
546414000579	Protein of unknown function (DUF418); Region: DUF418; cl12135
546414000580	Protein of unknown function (DUF418); Region: DUF418; pfam04235
546414000581	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
546414000582	Coenzyme A binding pocket [chemical binding]; other site
546414000583	conserved hypothetical protein, steroid delta-isomerase-related; Region: TIGR02096
546414000584	cell division protein ZipA; Provisional; Region: PRK03427
546414000585	A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194
546414000586	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
546414000587	minor groove reading motif; other site
546414000588	helix-hairpin-helix signature motif; other site
546414000589	substrate binding pocket [chemical binding]; other site
546414000590	active site
546414000591	Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576
546414000592	DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread  A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431
546414000593	DNA binding and oxoG recognition site [nucleotide binding]
546414000594	undecaprenyl pyrophosphate synthase; Provisional; Region: PRK14835
546414000595	Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020
546414000596	catalytic residue [active]
546414000597	putative FPP diphosphate  binding site; other site
546414000598	putative FPP binding hydrophobic cleft; other site
546414000599	dimer interface [polypeptide binding]; other site
546414000600	putative IPP diphosphate binding site; other site
546414000601	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4719
546414000602	Domain of unknown function DUF11; Region: DUF11; cl17728
546414000603	Domain of unknown function DUF11; Region: DUF11; pfam01345
546414000604	Domain of unknown function DUF11; Region: DUF11; pfam01345
546414000605	fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226
546414000606	Domain of unknown function DUF11; Region: DUF11; pfam01345
546414000607	Distinct helicase family with a unique C-terminal domain including a metal-binding cysteine cluster [General function prediction only]; Region: COG1205
546414000608	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
546414000609	ATP binding site [chemical binding]; other site
546414000610	putative Mg++ binding site [ion binding]; other site
546414000611	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
546414000612	nucleotide binding region [chemical binding]; other site
546414000613	ATP-binding site [chemical binding]; other site
546414000614	Domain of unknown function (DUF1998); Region: DUF1998; pfam09369
546414000615	Domain of unknown function (DUF4384); Region: DUF4384; pfam14326
546414000616	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
546414000617	CoenzymeA binding site [chemical binding]; other site
546414000618	subunit interaction site [polypeptide binding]; other site
546414000619	PHB binding site; other site
546414000620	Cupin domain; Region: Cupin_2; pfam07883
546414000621	short chain dehydrogenase; Provisional; Region: PRK06197
546414000622	retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327
546414000623	putative NAD(P) binding site [chemical binding]; other site
546414000624	active site
546414000625	Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363
546414000626	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
546414000627	metal binding site [ion binding]; metal-binding site
546414000628	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4222
546414000629	glycerophosphodiester phosphodiesterase; Provisional; Region: glpQ; PRK11143
546414000630	Glycerophosphodiester phosphodiesterase domain of Streptomycin coelicolor (GlpQ1) and similar proteins; Region: GDPD_ScGlpQ1_like; cd08602
546414000631	putative active site [active]
546414000632	catalytic site [active]
546414000633	putative metal binding site [ion binding]; other site
546414000634	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4222
546414000635	Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853
546414000636	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
546414000637	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
546414000638	putative acyl-acceptor binding pocket; other site
546414000639	Periplasmic binding protein YvrC.  These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria and archaea.  They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: YvrC; cd01143
546414000640	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
546414000641	putative binding site residues; other site
546414000642	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
546414000643	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
546414000644	ABC-ATPase subunit  interface; other site
546414000645	dimer interface [polypeptide binding]; other site
546414000646	putative PBP binding regions; other site
546414000647	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
546414000648	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
546414000649	Walker A/P-loop; other site
546414000650	ATP binding site [chemical binding]; other site
546414000651	Q-loop/lid; other site
546414000652	ABC transporter signature motif; other site
546414000653	Walker B; other site
546414000654	D-loop; other site
546414000655	H-loop/switch region; other site
546414000656	Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980
546414000657	dimer interface [polypeptide binding]; other site
546414000658	[2Fe-2S] cluster binding site [ion binding]; other site
546414000659	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
546414000660	HRDC domain; Region: HRDC; pfam00570
546414000661	Uncharacterized protein with a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG4867
546414000662	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
546414000663	metal ion-dependent adhesion site (MIDAS); other site
546414000664	DinB family; Region: DinB; cl17821
546414000665	DinB superfamily; Region: DinB_2; pfam12867
546414000666	large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567
546414000667	Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970
546414000668	Fe-S oxidoreductase, related to NifB/MoaA family [Energy production and conversion]; Region: COG1625
546414000669	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
546414000670	Protein of unknown function (DUF512); Region: DUF512; pfam04459
546414000671	lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209
546414000672	homopentamer interface [polypeptide binding]; other site
546414000673	active site
546414000674	bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311
546414000675	3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926
546414000676	GTP cyclohydrolase II (RibA).  GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641
546414000677	dimerization interface [polypeptide binding]; other site
546414000678	active site
546414000679	riboflavin synthase subunit alpha; Provisional; Region: PRK09289
546414000680	Lumazine binding domain; Region: Lum_binding; pfam00677
546414000681	Lumazine binding domain; Region: Lum_binding; pfam00677
546414000682	riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326
546414000683	Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284
546414000684	catalytic motif [active]
546414000685	Zn binding site [ion binding]; other site
546414000686	RibD C-terminal domain; Region: RibD_C; cl17279
546414000687	NAD-dependent deacetylase; Provisional; Region: PRK00481
546414000688	SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412
546414000689	NAD+ binding site [chemical binding]; other site
546414000690	substrate binding site [chemical binding]; other site
546414000691	Zn binding site [ion binding]; other site
546414000692	RNA:NAD 2'-phosphotransferase [Translation, ribosomal structure and biogenesis]; Region: KptA; COG1859
546414000693	RNA 2'-phosphotransferase, Tpt1 / KptA family; Region: PTS_2-RNA; pfam01885
546414000694	Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506
546414000695	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
546414000696	structural tetrad; other site
546414000697	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
546414000698	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
546414000699	endonuclease III; Region: ENDO3c; smart00478
546414000700	minor groove reading motif; other site
546414000701	helix-hairpin-helix signature motif; other site
546414000702	substrate binding pocket [chemical binding]; other site
546414000703	active site
546414000704	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
546414000705	nudix motif; other site
546414000706	EamA-like transporter family; Region: EamA; pfam00892
546414000707	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
546414000708	EamA-like transporter family; Region: EamA; pfam00892
546414000709	Predicted integral membrane protein [Function unknown]; Region: COG5637
546414000710	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_8; cd07817
546414000711	putative hydrophobic ligand binding site [chemical binding]; other site
546414000712	Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139
546414000713	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
546414000714	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
546414000715	YsiA-like protein, C-terminal region; Region: TetR_C_4; pfam08359
546414000716	Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079
546414000717	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
546414000718	pyridoxal 5'-phosphate binding site [chemical binding]; other site
546414000719	homodimer interface [polypeptide binding]; other site
546414000720	catalytic residue [active]
546414000721	Flagellin N-methylase; Region: FliB; cl00497
546414000722	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264
546414000723	dinuclear metal binding motif [ion binding]; other site
546414000724	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
546414000725	Peroxiredoxin (PRX) family, AhpE-like subfamily; composed of proteins similar to Mycobacterium tuberculosis AhpE. AhpE is described as a 1-cys PRX because of the absence of a resolving cysteine. The structure and sequence of AhpE, however, show greater...; Region: PRX_AhpE_like; cd03018
546414000726	dimer interface [polypeptide binding]; other site
546414000727	catalytic triad [active]
546414000728	GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929
546414000729	Glycosyl hydrolase family 43; Region: GH43_bXyl_2; cd08991
546414000730	active site
546414000731	Glycosyl hydrolase family 43; Region: GH43_ABN_2; cd08999
546414000732	putative substrate binding site [chemical binding]; other site
546414000733	active site
546414000734	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
546414000735	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
546414000736	dimer interface [polypeptide binding]; other site
546414000737	conserved gate region; other site
546414000738	putative PBP binding loops; other site
546414000739	ABC-ATPase subunit interface; other site
546414000740	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
546414000741	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
546414000742	putative PBP binding loops; other site
546414000743	dimer interface [polypeptide binding]; other site
546414000744	ABC-ATPase subunit interface; other site
546414000745	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
546414000746	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
546414000747	zinc/cadmium/mercury/lead-transporting ATPase; Provisional; Region: zntA; PRK11033
546414000748	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
546414000749	metal-binding site [ion binding]
546414000750	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
546414000751	Soluble P-type ATPase [General function prediction only]; Region: COG4087
546414000752	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
546414000753	dimerization interface [polypeptide binding]; other site
546414000754	putative DNA binding site [nucleotide binding]; other site
546414000755	putative Zn2+ binding site [ion binding]; other site
546414000756	DNA-directed RNA polymerase, subunit K/omega [Transcription]; Region: RpoZ; COG1758
546414000757	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317
546414000758	active site
546414000759	Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073
546414000760	Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309
546414000761	Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219
546414000762	MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554
546414000763	homotrimer interaction site [polypeptide binding]; other site
546414000764	zinc binding site [ion binding]; other site
546414000765	CDP-binding sites; other site
546414000766	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
546414000767	Major Facilitator Superfamily; Region: MFS_1; pfam07690
546414000768	putative substrate translocation pore; other site
546414000769	Uncharacterized conserved protein [Function unknown]; Region: COG1739
546414000770	Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205
546414000771	Domain of unknown function (DUF1949); Region: DUF1949; pfam09186
546414000772	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
546414000773	dimer interface [polypeptide binding]; other site
546414000774	ADP-ribose binding site [chemical binding]; other site
546414000775	active site
546414000776	nudix motif; other site
546414000777	metal binding site [ion binding]; metal-binding site
546414000778	Domain of unknown function (DUF4403); Region: DUF4403; pfam14356
546414000779	AAA domain; Region: AAA_33; pfam13671
546414000780	AAA domain; Region: AAA_17; pfam13207
546414000781	Uncharacterized conserved protein [Function unknown]; Region: COG0432
546414000782	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
546414000783	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
546414000784	GDP-binding site [chemical binding]; other site
546414000785	ACT binding site; other site
546414000786	IMP binding site; other site
546414000787	GTP cyclohydrolase I; Provisional; Region: PLN03044
546414000788	GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate.  The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria.  In...; Region: GTP_cyclohydro1; cd00642
546414000789	homodecamer interface [polypeptide binding]; other site
546414000790	active site
546414000791	putative catalytic site residues [active]
546414000792	zinc binding site [ion binding]; other site
546414000793	GTP-CH-I/GFRP interaction surface; other site
546414000794	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
546414000795	M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886
546414000796	metal binding site [ion binding]; metal-binding site
546414000797	dimer interface [polypeptide binding]; other site
546414000798	CheB methylesterase; Region: CheB_methylest; pfam01339
546414000799	CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705
546414000800	Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352
546414000801	CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739
546414000802	PAS fold; Region: PAS; pfam00989
546414000803	PAS domain; Region: PAS_10; pfam13596
546414000804	PAS domain; Region: PAS_8; pfam13188
546414000805	PAS fold; Region: PAS_4; pfam08448
546414000806	PAS domain S-box; Region: sensory_box; TIGR00229
546414000807	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
546414000808	putative active site [active]
546414000809	heme pocket [chemical binding]; other site
546414000810	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
546414000811	dimer interface [polypeptide binding]; other site
546414000812	phosphorylation site [posttranslational modification]
546414000813	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
546414000814	ATP binding site [chemical binding]; other site
546414000815	Mg2+ binding site [ion binding]; other site
546414000816	G-X-G motif; other site
546414000817	Chemotaxis response regulator containing a CheY-like receiver domain and a methylesterase domain [Cell motility and secretion / Signal transduction mechanisms]; Region: CheB; COG2201
546414000818	CheB methylesterase; Region: CheB_methylest; pfam01339
546414000819	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830
546414000820	Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196
546414000821	putative transposase OrfB; Reviewed; Region: PHA02517
546414000822	HTH-like domain; Region: HTH_21; pfam13276
546414000823	Integrase core domain; Region: rve; pfam00665
546414000824	Integrase core domain; Region: rve_3; pfam13683
546414000825	Transposase; Region: HTH_Tnp_1; pfam01527
546414000826	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
546414000827	Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974
546414000828	phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189
546414000829	Int/Topo IB signature motif; other site
546414000830	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
546414000831	DNA methylase; Region: N6_N4_Mtase; cl17433
546414000832	DNA methylase; Region: N6_N4_Mtase; pfam01555
546414000833	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
546414000834	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
546414000835	non-specific DNA binding site [nucleotide binding]; other site
546414000836	salt bridge; other site
546414000837	sequence-specific DNA binding site [nucleotide binding]; other site
546414000838	folylpolyglutamate synthase/dihydrofolate synthase; Region: folC; TIGR01499
546414000839	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
546414000840	Creatinine amidohydrolase; Region: Creatininase; pfam02633
546414000841	Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041
546414000842	phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019
546414000843	ATP-grasp domain; Region: ATP-grasp; pfam02222
546414000844	Uncharacterized vancomycin resistance protein [Defense mechanisms]; Region: COG2720
546414000845	VanW like protein; Region: VanW; pfam04294
546414000846	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
546414000847	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
546414000848	AAK_NAGK-like: N-Acetyl-L-glutamate kinase (NAGK)-like . Included in this CD are the Escherichia coli and Pseudomonas aeruginosa type NAGKs which catalyze the phosphorylation of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine...; Region: AAK_NAGK-like; cd04238
546414000849	nucleotide binding site [chemical binding]; other site
546414000850	N-acetyl-L-glutamate binding site [chemical binding]; other site
546414000851	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
546414000852	Coenzyme A binding pocket [chemical binding]; other site
546414000853	tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042
546414000854	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
546414000855	FMN binding site [chemical binding]; other site
546414000856	active site
546414000857	catalytic residues [active]
546414000858	substrate binding site [chemical binding]; other site
546414000859	DinB family; Region: DinB; cl17821
546414000860	DinB superfamily; Region: DinB_2; pfam12867
546414000861	Arginase family; Region: Arginase; cd09989
546414000862	active site
546414000863	Mn binding site [ion binding]; other site
546414000864	oligomer interface [polypeptide binding]; other site
546414000865	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
546414000866	active site
546414000867	metal binding site [ion binding]; metal-binding site
546414000868	Thermus thermophilus TTHA0053 and related proteins, metallophosphatase domain; Region: MPP_TTHA0053; cd07403
546414000869	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Deinococcus radiodurans DR2231 protein and its bacterial homologs; Region: NTP-PPase_DR2231; cd11544
546414000870	homodimer interface [polypeptide binding]; other site
546414000871	active site
546414000872	metal binding site [ion binding]; metal-binding site
546414000873	DdrB-like protein; Region: DdrB; pfam12747
546414000874	Uncharacterized conserved protein [Function unknown]; Region: COG3375
546414000875	N-acylamino acid racemase (NAAAR), an octameric enzyme that catalyzes the racemization of N-acylamino acids. NAAARs act on a broad range of N-acylamino acids rather than amino acids. Enantiopure amino acids are of industrial interest as chiral building...; Region: NAAAR; cd03317
546414000876	o-succinylbenzoate synthase; Region: menC_lowGC/arch; TIGR01928
546414000877	active site
546414000878	octamer interface [polypeptide binding]; other site
546414000879	Acyl CoA binding protein (ACBP) binds thiol esters of long fatty acids and coenzyme A in a one-to-one binding mode with high specificity and affinity. Acyl-CoAs are important intermediates in fatty lipid synthesis and fatty acid degradation and play a...; Region: ACBP; cl00221
546414000880	acyl-CoA binding pocket [chemical binding]; other site
546414000881	CoA binding site [chemical binding]; other site
546414000882	Predicted Zn peptidase [Amino acid transport and metabolism]; Region: COG2856
546414000883	Protein of unknown function (DUF1205); Region: DUF1205; pfam06722
546414000884	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
546414000885	dihydropteroate synthase; Region: DHPS; TIGR01496
546414000886	substrate binding pocket [chemical binding]; other site
546414000887	inhibitor binding site; inhibition site
546414000888	Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1),  6-pyrovoyl...; Region: TFold; cl00263
546414000889	active site
546414000890	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
546414000891	catalytic center binding site [active]
546414000892	ATP binding site [chemical binding]; other site
546414000893	hypothetical protein; Reviewed; Region: PRK12497
546414000894	Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637
546414000895	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
546414000896	active site
546414000897	motif I; other site
546414000898	motif II; other site
546414000899	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
546414000900	dsRNA binding site [nucleotide binding]; other site
546414000901	Xanthine/uracil permeases [Nucleotide transport and metabolism]; Region: UraA; COG2233
546414000902	excinuclease ABC subunit B; Provisional; Region: PRK05298
546414000903	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
546414000904	ATP binding site [chemical binding]; other site
546414000905	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
546414000906	nucleotide binding region [chemical binding]; other site
546414000907	ATP-binding site [chemical binding]; other site
546414000908	Ultra-violet resistance protein B; Region: UvrB; pfam12344
546414000909	UvrB/uvrC motif; Region: UVR; pfam02151
546414000910	DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986
546414000911	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
546414000912	The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414
546414000913	dimerization interface [polypeptide binding]; other site
546414000914	substrate binding pocket [chemical binding]; other site
546414000915	helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344
546414000916	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
546414000917	putative DNA binding site [nucleotide binding]; other site
546414000918	putative Zn2+ binding site [ion binding]; other site
546414000919	AsnC family; Region: AsnC_trans_reg; pfam01037
546414000920	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
546414000921	EamA-like transporter family; Region: EamA; pfam00892
546414000922	EamA-like transporter family; Region: EamA; pfam00892
546414000923	pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405
546414000924	Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017
546414000925	dimer interface [polypeptide binding]; other site
546414000926	TPP-binding site [chemical binding]; other site
546414000927	Transketolase, pyrimidine binding domain; Region: Transket_pyr; smart00861
546414000928	pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase, long form; Region: PDHac_trf_long; TIGR01348
546414000929	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
546414000930	E3 interaction surface; other site
546414000931	lipoyl attachment site [posttranslational modification]; other site
546414000932	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
546414000933	E3 interaction surface; other site
546414000934	lipoyl attachment site [posttranslational modification]; other site
546414000935	e3 binding domain; Region: E3_binding; pfam02817
546414000936	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
546414000937	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
546414000938	motif II; other site
546414000939	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
546414000940	active site
546414000941	catalytic residues [active]
546414000942	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
546414000943	classical (c) SDRs; Region: SDR_c; cd05233
546414000944	NAD(P) binding site [chemical binding]; other site
546414000945	active site
546414000946	Uncharacterized conserved protein [Function unknown]; Region: COG4850
546414000947	Uncharacterized conserved protein (DUF2183); Region: DUF2183; pfam09949
546414000948	Exoribonuclease R [Transcription]; Region: VacB; COG0557
546414000949	Ribonuclease B OB domain; Region: OB_RNB; pfam08206
546414000950	RNB domain; Region: RNB; pfam00773
546414000951	S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471
546414000952	RNA binding site [nucleotide binding]; other site
546414000953	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
546414000954	putative catalytic site [active]
546414000955	putative metal binding site [ion binding]; other site
546414000956	putative phosphate binding site [ion binding]; other site
546414000957	Intradiol dioxygenase supgroup. Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. They break the catechol C1-C2 bond and utilize Fe3+, as opposed to  the...; Region: intradiol_dioxygenase_like; cd03457
546414000958	putative active site [active]
546414000959	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
546414000960	S-adenosylmethionine binding site [chemical binding]; other site
546414000961	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
546414000962	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
546414000963	ATP-grasp domain; Region: ATP-grasp_4; cl17255
546414000964	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
546414000965	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
546414000966	carboxyltransferase (CT) interaction site; other site
546414000967	biotinylation site [posttranslational modification]; other site
546414000968	elongation factor P; Validated; Region: PRK00529
546414000969	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
546414000970	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
546414000971	RNA binding site [nucleotide binding]; other site
546414000972	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
546414000973	RNA binding site [nucleotide binding]; other site
546414000974	50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618
546414000975	Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495
546414000976	5S rRNA interface [nucleotide binding]; other site
546414000977	CTC domain interface [polypeptide binding]; other site
546414000978	L16 interface [polypeptide binding]; other site
546414000979	Domain of unknown function (DUF4142); Region: DUF4142; pfam13628
546414000980	Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719
546414000981	FeS assembly protein SufD; Region: sufD; TIGR01981
546414000982	cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223
546414000983	FeS assembly protein SufB; Region: sufB; TIGR01980
546414000984	Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396
546414000985	ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217
546414000986	Walker A/P-loop; other site
546414000987	ATP binding site [chemical binding]; other site
546414000988	Q-loop/lid; other site
546414000989	ABC transporter signature motif; other site
546414000990	Walker B; other site
546414000991	D-loop; other site
546414000992	H-loop/switch region; other site
546414000993	Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811
546414000994	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
546414000995	Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472
546414000996	putative acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK05641
546414000997	pantothenate kinase; Reviewed; Region: PRK13318
546414000998	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
546414000999	Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392
546414001000	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
546414001001	metal binding site [ion binding]; metal-binding site
546414001002	active site
546414001003	I-site; other site
546414001004	uncharacterized proteins similar to the Aspergillus nidulans lactam utilization protein LamB; Region: LamB_YcsF_like_1; cd10801
546414001005	putative active site [active]
546414001006	Allophanate hydrolase subunit 2; Region: AHS2; smart00797
546414001007	Allophanate hydrolase subunit 1; Region: AHS1; pfam02682
546414001008	Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896
546414001009	Predicted amidohydrolase [General function prediction only]; Region: COG0388
546414001010	Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424
546414001011	active site
546414001012	catalytic triad [active]
546414001013	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
546414001014	RNA polymerase sigma factor RpoD, C-terminal domain; Region: RpoD_Cterm; TIGR02393
546414001015	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
546414001016	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
546414001017	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
546414001018	DNA binding residues [nucleotide binding]
546414001019	Predicted ATPase [General function prediction only]; Region: COG3903
546414001020	Tetratricopeptide repeat; Region: TPR_12; pfam13424
546414001021	Tetratricopeptide repeat; Region: TPR_12; pfam13424
546414001022	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
546414001023	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
546414001024	DNA binding residues [nucleotide binding]
546414001025	dimerization interface [polypeptide binding]; other site
546414001026	Domain of unknown function (DUF4397); Region: DUF4397; pfam14344
546414001027	PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392
546414001028	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
546414001029	active site
546414001030	ATP-grasp domain; Region: ATP-grasp_4; pfam13535
546414001031	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
546414001032	Alcohol dehydrogenases of the MDR family; Region: Zn_ADH6; cd08260
546414001033	putative NAD(P) binding site [chemical binding]; other site
546414001034	catalytic Zn binding site [ion binding]; other site
546414001035	structural Zn binding site [ion binding]; other site
546414001036	acetyl-CoA acetyltransferase; Provisional; Region: PRK07108
546414001037	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
546414001038	dimer interface [polypeptide binding]; other site
546414001039	active site
546414001040	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
546414001041	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
546414001042	Walker A/P-loop; other site
546414001043	ATP binding site [chemical binding]; other site
546414001044	Q-loop/lid; other site
546414001045	ABC transporter signature motif; other site
546414001046	Walker B; other site
546414001047	D-loop; other site
546414001048	H-loop/switch region; other site
546414001049	Predicted transcriptional regulators [Transcription]; Region: COG1725
546414001050	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
546414001051	DNA-binding site [nucleotide binding]; DNA binding site
546414001052	Predicted GTPases [General function prediction only]; Region: COG1162
546414001053	Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854
546414001054	GTPase/Zn-binding domain interface [polypeptide binding]; other site
546414001055	GTP/Mg2+ binding site [chemical binding]; other site
546414001056	G4 box; other site
546414001057	G5 box; other site
546414001058	G1 box; other site
546414001059	Switch I region; other site
546414001060	G2 box; other site
546414001061	G3 box; other site
546414001062	Switch II region; other site
546414001063	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
546414001064	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
546414001065	active site
546414001066	catalytic tetrad [active]
546414001067	Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363
546414001068	M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656
546414001069	oligomer interface [polypeptide binding]; other site
546414001070	active site
546414001071	metal binding site [ion binding]; metal-binding site
546414001072	Tetratricopeptide repeat; Region: TPR_12; pfam13424
546414001073	TPR repeat; Region: TPR_11; pfam13414
546414001074	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
546414001075	binding surface
546414001076	TPR motif; other site
546414001077	Tetratricopeptide repeat; Region: TPR_12; pfam13424
546414001078	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
546414001079	binding surface
546414001080	TPR motif; other site
546414001081	Tetratricopeptide repeat; Region: TPR_12; pfam13424
546414001082	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
546414001083	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
546414001084	dimer interface [polypeptide binding]; other site
546414001085	phosphorylation site [posttranslational modification]
546414001086	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
546414001087	ATP binding site [chemical binding]; other site
546414001088	Mg2+ binding site [ion binding]; other site
546414001089	G-X-G motif; other site
546414001090	Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738
546414001091	Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738
546414001092	Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149
546414001093	active site
546414001094	Cupin domain; Region: Cupin_2; pfam07883
546414001095	Cupin domain; Region: Cupin_2; pfam07883
546414001096	SGNH_hydrolase subfamily. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site...; Region: SGNH_hydrolase_like_2; cd01834
546414001097	active site
546414001098	catalytic triad [active]
546414001099	oxyanion hole [active]
546414001100	Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808
546414001101	xylulokinase; Provisional; Region: PRK15027
546414001102	N- and C-terminal domain interface [polypeptide binding]; other site
546414001103	active site
546414001104	MgATP binding site [chemical binding]; other site
546414001105	catalytic site [active]
546414001106	metal binding site [ion binding]; metal-binding site
546414001107	xylulose binding site [chemical binding]; other site
546414001108	homodimer interface [polypeptide binding]; other site
546414001109	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
546414001110	GAF domain; Region: GAF; pfam01590
546414001111	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
546414001112	PAS domain; Region: PAS_9; pfam13426
546414001113	putative active site [active]
546414001114	heme pocket [chemical binding]; other site
546414001115	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
546414001116	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
546414001117	metal binding site [ion binding]; metal-binding site
546414001118	active site
546414001119	I-site; other site
546414001120	GAF domain; Region: GAF_3; pfam13492
546414001121	GAF domain; Region: GAF_2; pfam13185
546414001122	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
546414001123	Zn2+ binding site [ion binding]; other site
546414001124	Mg2+ binding site [ion binding]; other site
546414001125	DEAD-like helicases superfamily; Region: DEXDc; smart00487
546414001126	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
546414001127	ATP binding site [chemical binding]; other site
546414001128	putative Mg++ binding site [ion binding]; other site
546414001129	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
546414001130	nucleotide binding region [chemical binding]; other site
546414001131	ATP-binding site [chemical binding]; other site
546414001132	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3224
546414001133	Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572
546414001134	histidinol dehydrogenase; Region: hisD; TIGR00069
546414001135	NAD binding site [chemical binding]; other site
546414001136	dimerization interface [polypeptide binding]; other site
546414001137	product binding site; other site
546414001138	substrate binding site [chemical binding]; other site
546414001139	zinc binding site [ion binding]; other site
546414001140	catalytic residues [active]
546414001141	phosphopentomutase; Provisional; Region: PRK05362
546414001142	Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676
546414001143	ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137
546414001144	ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218
546414001145	Walker A/P-loop; other site
546414001146	ATP binding site [chemical binding]; other site
546414001147	Q-loop/lid; other site
546414001148	ABC transporter signature motif; other site
546414001149	Walker B; other site
546414001150	D-loop; other site
546414001151	H-loop/switch region; other site
546414001152	Protein of unknown function (DUF3084); Region: DUF3084; pfam11283
546414001153	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
546414001154	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
546414001155	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
546414001156	active site
546414001157	catalytic residues [active]
546414001158	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
546414001159	TPR motif; other site
546414001160	Tetratricopeptide repeat; Region: TPR_12; pfam13424
546414001161	binding surface
546414001162	Tetratricopeptide repeat; Region: TPR_12; pfam13424
546414001163	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
546414001164	binding surface
546414001165	TPR motif; other site
546414001166	Tetratricopeptide repeat; Region: TPR_12; pfam13424
546414001167	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
546414001168	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
546414001169	metal binding site [ion binding]; metal-binding site
546414001170	active site
546414001171	I-site; other site
546414001172	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
546414001173	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
546414001174	TrkA-N domain; Region: TrkA_N; pfam02254
546414001175	TrkA-C domain; Region: TrkA_C; pfam02080
546414001176	Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168
546414001177	potassium uptake protein, TrkH family; Region: 2a38; TIGR00933
546414001178	Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116
546414001179	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
546414001180	S-adenosylmethionine binding site [chemical binding]; other site
546414001181	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
546414001182	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
546414001183	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
546414001184	Domain of unknown function (DUF4131); Region: DUF4131; pfam13567
546414001185	Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658
546414001186	Competence protein; Region: Competence; pfam03772
546414001187	Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333
546414001188	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
546414001189	Helix-hairpin-helix motif; Region: HHH_3; pfam12836
546414001190	RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966
546414001191	50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399
546414001192	Ribonuclease P; Region: Ribonuclease_P; cl00457
546414001193	hypothetical protein; Provisional; Region: PRK14383
546414001194	Preprotein translocase subunit YidC [Intracellular trafficking and secretion]; Region: YidC; COG0706
546414001195	membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592
546414001196	Peptidase_C39 like family; Region: Peptidase_C39_2; pfam13529
546414001197	putative active site [active]
546414001198	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
546414001199	binding surface
546414001200	TPR motif; other site
546414001201	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
546414001202	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
546414001203	alpha subunit interface [polypeptide binding]; other site
546414001204	TPP binding site [chemical binding]; other site
546414001205	heterodimer interface [polypeptide binding]; other site
546414001206	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
546414001207	pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181
546414001208	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
546414001209	tetramer interface [polypeptide binding]; other site
546414001210	TPP-binding site [chemical binding]; other site
546414001211	heterodimer interface [polypeptide binding]; other site
546414001212	phosphorylation loop region [posttranslational modification]
546414001213	Domain of unknown function (DUF4384); Region: DUF4384; pfam14326
546414001214	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
546414001215	Moco binding site; other site
546414001216	metal coordination site [ion binding]; other site
546414001217	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
546414001218	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
546414001219	ATP binding site [chemical binding]; other site
546414001220	Mg2+ binding site [ion binding]; other site
546414001221	G-X-G motif; other site
546414001222	polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146
546414001223	Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340
546414001224	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
546414001225	RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652
546414001226	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
546414001227	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
546414001228	DNA binding residues [nucleotide binding]
546414001229	Uncharacterized conserved protein [Function unknown]; Region: COG2383
546414001230	Transcriptional regulators [Transcription]; Region: PurR; COG1609
546414001231	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
546414001232	DNA binding site [nucleotide binding]
546414001233	domain linker motif; other site
546414001234	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
546414001235	Protein of unknown function (DUF461); Region: DUF461; pfam04314
546414001236	Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999
546414001237	SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968
546414001238	Cu(I) binding site [ion binding]; other site
546414001239	Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; cl09173
546414001240	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
546414001241	active site
546414001242	Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799
546414001243	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
546414001244	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
546414001245	methionine sulfoxide reductase B; Provisional; Region: PRK00222
546414001246	SelR domain; Region: SelR; pfam01641
546414001247	Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340
546414001248	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
546414001249	Mg-chelatase subunit ChlI [Coenzyme metabolism]; Region: ChlI; COG1239
546414001250	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
546414001251	active site
546414001252	Helix-Turn-Helix DNA binding domain of the SoxR transcription regulator; Region: HTH_SoxR; cd01110
546414001253	redox-sensitive transcriptional activator SoxR; Region: SoxR; TIGR01950
546414001254	DNA binding residues [nucleotide binding]
546414001255	dimer interface [polypeptide binding]; other site
546414001256	[2Fe-2S] cluster binding site [ion binding]; other site
546414001257	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
546414001258	Coenzyme A binding pocket [chemical binding]; other site
546414001259	AAA ATPase domain; Region: AAA_16; pfam13191
546414001260	Predicted ATPase [General function prediction only]; Region: COG3903
546414001261	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
546414001262	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
546414001263	DNA binding residues [nucleotide binding]
546414001264	dimerization interface [polypeptide binding]; other site
546414001265	aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477
546414001266	GatB/GatE catalytic domain; Region: GatB_N; pfam02934
546414001267	GatB domain; Region: GatB_Yqey; smart00845
546414001268	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
546414001269	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
546414001270	substrate binding site [chemical binding]; other site
546414001271	ATP binding site [chemical binding]; other site
546414001272	YceG-like family; Region: YceG; pfam02618
546414001273	proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010
546414001274	dimerization interface [polypeptide binding]; other site
546414001275	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
546414001276	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
546414001277	catalytic loop [active]
546414001278	iron binding site [ion binding]; other site
546414001279	Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001
546414001280	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
546414001281	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
546414001282	active site
546414001283	Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382
546414001284	Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165
546414001285	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544
546414001286	Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165
546414001287	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830
546414001288	PilX N-terminal; Region: PilX_N; pfam14341
546414001289	A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39A; cd02549
546414001290	putative active site [active]
546414001291	AAA domain; Region: AAA_17; pfam13207
546414001292	Enterochelin esterase and related enzymes [Inorganic ion transport and metabolism]; Region: Fes; COG2382
546414001293	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819
546414001294	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07008
546414001295	Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; Region: ttLC_FACS_AlkK_like; cd12119
546414001296	dimer interface [polypeptide binding]; other site
546414001297	acyl-activating enzyme (AAE) consensus motif; other site
546414001298	putative active site [active]
546414001299	AMP binding site [chemical binding]; other site
546414001300	putative CoA binding site [chemical binding]; other site
546414001301	Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652
546414001302	enoyl-CoA hydratase; Provisional; Region: PRK08140
546414001303	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
546414001304	substrate binding site [chemical binding]; other site
546414001305	oxyanion hole (OAH) forming residues; other site
546414001306	trimer interface [polypeptide binding]; other site
546414001307	Protein of unknown function (DUF4242); Region: DUF4242; pfam14026
546414001308	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
546414001309	Peptidase family M23; Region: Peptidase_M23; pfam01551
546414001310	Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823
546414001311	Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350
546414001312	Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053
546414001313	Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348
546414001314	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
546414001315	tetramer interface [polypeptide binding]; other site
546414001316	threonine dehydratase; Reviewed; Region: PRK09224
546414001317	pyridoxal 5'-phosphate binding site [chemical binding]; other site
546414001318	catalytic residue [active]
546414001319	First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906
546414001320	putative Ile/Val binding site [chemical binding]; other site
546414001321	Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907
546414001322	putative Ile/Val binding site [chemical binding]; other site
546414001323	FAD dependent oxidoreductase; Region: DAO; pfam01266
546414001324	Stage II sporulation protein; Region: SpoIID; pfam08486
546414001325	SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669
546414001326	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
546414001327	Beta-lactamase; Region: Beta-lactamase; cl17358
546414001328	L-asparaginase II; Region: Asparaginase_II; pfam06089
546414001329	arginine decarboxylase; Provisional; Region: PRK05354
546414001330	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830
546414001331	dimer interface [polypeptide binding]; other site
546414001332	active site
546414001333	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
546414001334	catalytic residues [active]
546414001335	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261
546414001336	SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265
546414001337	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
546414001338	S-adenosylmethionine binding site [chemical binding]; other site
546414001339	Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561
546414001340	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
546414001341	4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK14662
546414001342	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
546414001343	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
546414001344	active site
546414001345	NTP binding site [chemical binding]; other site
546414001346	metal binding triad [ion binding]; metal-binding site
546414001347	antibiotic binding site [chemical binding]; other site
546414001348	Uncharacterized conserved protein [Function unknown]; Region: COG2361
546414001349	Peptidases of the G1 family and homologs that might lack peptidase activity; Region: Peptidase_G1_like; cl03371
546414001350	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
546414001351	active site
546414001352	catalytic tetrad [active]
546414001353	thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284
546414001354	ThiC-associated domain; Region: ThiC-associated; pfam13667
546414001355	ThiC family; Region: ThiC; pfam01964
546414001356	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
546414001357	thiamine phosphate binding site [chemical binding]; other site
546414001358	active site
546414001359	pyrophosphate binding site [ion binding]; other site
546414001360	ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565
546414001361	thiS-thiF/thiG interaction site; other site
546414001362	Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728
546414001363	ThiS interaction site; other site
546414001364	putative active site [active]
546414001365	tetramer interface [polypeptide binding]; other site
546414001366	glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352
546414001367	glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352
546414001368	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
546414001369	dimer interface [polypeptide binding]; other site
546414001370	substrate binding site [chemical binding]; other site
546414001371	ATP binding site [chemical binding]; other site
546414001372	phenylacetate-CoA oxygenase subunit PaaA; Provisional; Region: paaA; PRK13778
546414001373	phenylacetate-CoA oxygenase, PaaG subunit; Region: PA_CoA_Oxy1; TIGR02156
546414001374	Uncharacterized enzyme of phenylacetate metabolism [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3460
546414001375	Phenylacetic acid degradation B; Region: PaaB; cl01371
546414001376	Phenylacetic acid catabolic protein; Region: PaaA_PaaC; pfam05138
546414001377	Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151
546414001378	phenylacetate-CoA oxygenase, PaaJ subunit; Region: PA_CoA_Oxy4; TIGR02159
546414001379	bifunctional aldehyde dehydrogenase/enoyl-CoA hydratase; Provisional; Region: PRK11563
546414001380	N-terminal domain of the monoamine oxidase C dehydratase; Region: ALDH_MaoC-N; cd07128
546414001381	substrate binding site [chemical binding]; other site
546414001382	dimer interface [polypeptide binding]; other site
546414001383	NADP binding site [chemical binding]; other site
546414001384	catalytic residues [active]
546414001385	MaoC_C  The C-terminal hot dog fold of the MaoC (monoamine oxidase C) dehydratase regulatory protein. Orthologs of MaoC include PaaZ [Escherichia coli] and PaaN [Pseudomonas putida], which are putative ring-opening enzymes involved in phenylacetic acid...; Region: MaoC_C; cd03452
546414001386	substrate binding site [chemical binding]; other site
546414001387	Predicted periplasmic protein [Function unknown]; Region: COG3698
546414001388	Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992
546414001389	short chain dehydrogenase; Provisional; Region: PRK07109
546414001390	classical (c) SDR, subgroup 3; Region: SDR_c3; cd05360
546414001391	putative NAD(P) binding site [chemical binding]; other site
546414001392	active site
546414001393	Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613
546414001394	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase; Region: PHP_HisPPase; cd07432
546414001395	active site
546414001396	PHP-associated; Region: PHP_C; pfam13263
546414001397	Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597
546414001398	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
546414001399	dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606
546414001400	Ribonucleotide reductase, all-alpha domain; Region: Ribonuc_red_lgN; pfam00317
546414001401	Ribonucleotide reductase, alpha subunit [Nucleotide transport and metabolism]; Region: NrdA; COG0209
546414001402	Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939
546414001403	Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888
546414001404	effector binding site; other site
546414001405	dimer interface [polypeptide binding]; other site
546414001406	active site
546414001407	Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939
546414001408	TSCPD domain; Region: TSCPD; pfam12637
546414001409	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Provisional; Region: PRK14618
546414001410	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
546414001411	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
546414001412	SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500
546414001413	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
546414001414	S-adenosylmethionine binding site [chemical binding]; other site
546414001415	Uncharacterized protein conserved in bacteria (DUF2141); Region: DUF2141; cl01930
546414001416	Domain of unknown function (DUF1802); Region: DUF1802; pfam08819
546414001417	replicative DNA helicase; Region: DnaB; TIGR00665
546414001418	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
546414001419	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
546414001420	Walker A motif; other site
546414001421	ATP binding site [chemical binding]; other site
546414001422	Walker B motif; other site
546414001423	DNA binding loops [nucleotide binding]
546414001424	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883
546414001425	nudix motif; other site
546414001426	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
546414001427	NAD(P) binding site [chemical binding]; other site
546414001428	transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464
546414001429	ATP cone domain; Region: ATP-cone; pfam03477
546414001430	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
546414001431	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
546414001432	TM-ABC transporter signature motif; other site
546414001433	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
546414001434	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
546414001435	TM-ABC transporter signature motif; other site
546414001436	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
546414001437	Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327
546414001438	putative ligand binding site [chemical binding]; other site
546414001439	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
546414001440	urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410
546414001441	Walker A/P-loop; other site
546414001442	ATP binding site [chemical binding]; other site
546414001443	Q-loop/lid; other site
546414001444	ABC transporter signature motif; other site
546414001445	Walker B; other site
546414001446	D-loop; other site
546414001447	H-loop/switch region; other site
546414001448	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
546414001449	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
546414001450	Walker A/P-loop; other site
546414001451	ATP binding site [chemical binding]; other site
546414001452	Q-loop/lid; other site
546414001453	ABC transporter signature motif; other site
546414001454	Walker B; other site
546414001455	D-loop; other site
546414001456	H-loop/switch region; other site
546414001457	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
546414001458	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ABO13168; Region: LPLAT_ABO13168-like; cd07988
546414001459	putative acyl-acceptor binding pocket; other site
546414001460	EVE domain; Region: EVE; cl00728
546414001461	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
546414001462	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
546414001463	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
546414001464	aldose 1-epimerase, similar to Escherichia coli YphB; Region: Aldose_epim_Ec_YphB; cd09021
546414001465	active site
546414001466	catalytic residues [active]
546414001467	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
546414001468	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032
546414001469	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
546414001470	PAS fold; Region: PAS_4; pfam08448
546414001471	PAS domain; Region: PAS_9; pfam13426
546414001472	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
546414001473	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
546414001474	metal binding site [ion binding]; metal-binding site
546414001475	active site
546414001476	I-site; other site
546414001477	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
546414001478	Protein of unknown function (DUF3197); Region: DUF3197; pfam11432
546414001479	Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302
546414001480	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940
546414001481	AFG1-like ATPase; Region: AFG1_ATPase; pfam03969
546414001482	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
546414001483	CHC2 zinc finger; Region: zf-CHC2; cl17510
546414001484	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
546414001485	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
546414001486	active site
546414001487	metal binding site [ion binding]; metal-binding site
546414001488	interdomain interaction site; other site
546414001489	A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134
546414001490	intracellular protease, PfpI family; Region: PfpI; TIGR01382
546414001491	proposed catalytic triad [active]
546414001492	conserved cys residue [active]
546414001493	Cupin domain; Region: Cupin_2; pfam07883
546414001494	SnoaL-like domain; Region: SnoaL_2; pfam12680
546414001495	Predicted membrane protein [Function unknown]; Region: COG2323
546414001496	glycine dehydrogenase; Provisional; Region: PRK05367
546414001497	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
546414001498	tetramer interface [polypeptide binding]; other site
546414001499	pyridoxal 5'-phosphate binding site [chemical binding]; other site
546414001500	catalytic residue [active]
546414001501	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
546414001502	tetramer interface [polypeptide binding]; other site
546414001503	pyridoxal 5'-phosphate binding site [chemical binding]; other site
546414001504	catalytic residue [active]
546414001505	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
546414001506	lipoyl attachment site [posttranslational modification]; other site
546414001507	glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389
546414001508	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
546414001509	recombination factor protein RarA; Reviewed; Region: PRK13342
546414001510	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
546414001511	Walker A motif; other site
546414001512	ATP binding site [chemical binding]; other site
546414001513	Walker B motif; other site
546414001514	arginine finger; other site
546414001515	MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
546414001516	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
546414001517	NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, subunit 9, 39 kDa, (NDUFA9) -like, atypical (a) SDRs; Region: NDUFA9_like_SDR_a; cd05271
546414001518	putative NAD(P) binding site [chemical binding]; other site
546414001519	active site
546414001520	Mismatch repair ATPase (MutS family) [DNA replication, recombination, and repair]; Region: COG1193
546414001521	MutS domain III; Region: MutS_III; pfam05192
546414001522	ATP-binding cassette domain of MutS2; Region: ABC_MutS2; cd03280
546414001523	Walker A/P-loop; other site
546414001524	ATP binding site [chemical binding]; other site
546414001525	Q-loop/lid; other site
546414001526	ABC transporter signature motif; other site
546414001527	Walker B; other site
546414001528	D-loop; other site
546414001529	H-loop/switch region; other site
546414001530	ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192
546414001531	Smr domain; Region: Smr; pfam01713
546414001532	Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738
546414001533	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
546414001534	Uncharacterized conserved protein, YhbC family [Function unknown]; Region: COG0782
546414001535	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
546414001536	lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484
546414001537	LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322
546414001538	dimer interface [polypeptide binding]; other site
546414001539	putative anticodon binding site; other site
546414001540	Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775
546414001541	motif 1; other site
546414001542	active site
546414001543	motif 2; other site
546414001544	motif 3; other site
546414001545	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220
546414001546	putative DNA binding site [nucleotide binding]; other site
546414001547	putative Zn2+ binding site [ion binding]; other site
546414001548	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
546414001549	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
546414001550	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
546414001551	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
546414001552	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
546414001553	ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism]; Region: UgpA; COG1175
546414001554	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
546414001555	conserved gate region; other site
546414001556	putative PBP binding loops; other site
546414001557	ABC-ATPase subunit interface; other site
546414001558	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
546414001559	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
546414001560	dimer interface [polypeptide binding]; other site
546414001561	conserved gate region; other site
546414001562	putative PBP binding loops; other site
546414001563	ABC-ATPase subunit interface; other site
546414001564	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
546414001565	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
546414001566	dimer interface [polypeptide binding]; other site
546414001567	phosphorylation site [posttranslational modification]
546414001568	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
546414001569	ATP binding site [chemical binding]; other site
546414001570	Mg2+ binding site [ion binding]; other site
546414001571	G-X-G motif; other site
546414001572	NADH:ubiquinone oxidoreductase subunit 3 (chain A) [Energy production and conversion]; Region: NuoA; COG0838
546414001573	NADH dehydrogenase subunit B; Validated; Region: PRK06411
546414001574	Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl16917
546414001575	NADH:ubiquinone oxidoreductase 27 kD subunit [Energy production and conversion]; Region: NuoC; COG0852
546414001576	NADH dehydrogenase I, D subunit; Region: NuoD; TIGR01962
546414001577	NADH dehydrogenase subunit D; Validated; Region: PRK06075
546414001578	NADH-quinone oxidoreductase, E subunit; Region: nuoE_fam; TIGR01958
546414001579	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064
546414001580	putative dimer interface [polypeptide binding]; other site
546414001581	[2Fe-2S] cluster binding site [ion binding]; other site
546414001582	NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894
546414001583	SLBB domain; Region: SLBB; pfam10531
546414001584	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928
546414001585	NADH-quinone oxidoreductase, chain G; Region: NuoG; TIGR01973
546414001586	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
546414001587	catalytic loop [active]
546414001588	iron binding site [ion binding]; other site
546414001589	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588
546414001590	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
546414001591	molybdopterin cofactor binding site; other site
546414001592	NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076
546414001593	Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650
546414001594	NADH dehydrogenase subunit I; Provisional; Region: PRK05888
546414001595	4Fe-4S binding domain; Region: Fer4; pfam00037
546414001596	4Fe-4S binding domain; Region: Fer4; pfam00037
546414001597	NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638
546414001598	NADH dehydrogenase subunit J; Provisional; Region: PRK06433
546414001599	NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715
546414001600	NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590
546414001601	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662
546414001602	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
546414001603	proton-translocating NADH-quinone oxidoreductase, chain M; Region: NDH_I_M; TIGR01972
546414001604	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
546414001605	proton-translocating NADH-quinone oxidoreductase, chain N; Region: NDH_I_N; TIGR01770
546414001606	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
546414001607	CHASE2 domain; Region: CHASE2; pfam05226
546414001608	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
546414001609	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
546414001610	metal binding site [ion binding]; metal-binding site
546414001611	active site
546414001612	I-site; other site
546414001613	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
546414001614	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
546414001615	Walker A/P-loop; other site
546414001616	ATP binding site [chemical binding]; other site
546414001617	Q-loop/lid; other site
546414001618	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
546414001619	ABC transporter signature motif; other site
546414001620	Walker B; other site
546414001621	ABC transporter; Region: ABC_tran_2; pfam12848
546414001622	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
546414001623	Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561
546414001624	Uncharacterized protein involved in tellurite resistance [Inorganic ion transport and metabolism]; Region: TelA; COG3853
546414001625	Protoporphyrinogen oxidase [Coenzyme metabolism]; Region: HemY; COG1232
546414001626	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
546414001627	Protoheme ferro-lyase (ferrochelatase) [Coenzyme metabolism]; Region: HemH; COG0276
546414001628	Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411
546414001629	C-terminal domain interface [polypeptide binding]; other site
546414001630	active site
546414001631	Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419
546414001632	active site
546414001633	N-terminal domain interface [polypeptide binding]; other site
546414001634	Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717
546414001635	substrate binding site [chemical binding]; other site
546414001636	active site
546414001637	FlgD Ig-like domain; Region: FlgD_ig; pfam13860
546414001638	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
546414001639	CESA_like is  the cellulose synthase superfamily; Region: CESA_like; cd06423
546414001640	DXD motif; other site
546414001641	Beta-mannanase [Carbohydrate transport and metabolism]; Region: ManB; COG4124
546414001642	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
546414001643	Glu-tRNAGln amidotransferase C subunit; Region: Glu-tRNAGln; pfam02686
546414001644	seryl-tRNA synthetase; Provisional; Region: PRK05431
546414001645	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
546414001646	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770
546414001647	dimer interface [polypeptide binding]; other site
546414001648	active site
546414001649	motif 1; other site
546414001650	motif 2; other site
546414001651	motif 3; other site
546414001652	DinB superfamily; Region: DinB_2; pfam12867
546414001653	comF family protein; Region: comF; TIGR00201
546414001654	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
546414001655	active site
546414001656	Protein of unknown function (DUF1684); Region: DUF1684; pfam07920
546414001657	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
546414001658	RNA binding surface [nucleotide binding]; other site
546414001659	Predicted Zn-dependent peptidases, insulinase-like [General function prediction only]; Region: COG1026
546414001660	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
546414001661	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
546414001662	Peptidase M16C associated; Region: M16C_assoc; pfam08367
546414001663	tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291
546414001664	GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396
546414001665	trmE is a tRNA modification GTPase; Region: trmE; cd04164
546414001666	G1 box; other site
546414001667	GTP/Mg2+ binding site [chemical binding]; other site
546414001668	Switch I region; other site
546414001669	G2 box; other site
546414001670	Switch II region; other site
546414001671	G3 box; other site
546414001672	G4 box; other site
546414001673	G5 box; other site
546414001674	Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631
546414001675	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
546414001676	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
546414001677	substrate binding pocket [chemical binding]; other site
546414001678	membrane-bound complex binding site; other site
546414001679	hinge residues; other site
546414001680	Domain of unknown function (DUF4258); Region: DUF4258; pfam14076
546414001681	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
546414001682	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
546414001683	Coenzyme A binding pocket [chemical binding]; other site
546414001684	Domain of unknown function (DUF305); Region: DUF305; pfam03713
546414001685	Uncharacterized conserved protein [Function unknown]; Region: COG1434
546414001686	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
546414001687	putative active site [active]
546414001688	tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335
546414001689	Glucose inhibited division protein A; Region: GIDA; pfam01134
546414001690	UDP-N-acetylmuramoylalanine--D-glutamate ligase; Region: murD; TIGR01087
546414001691	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
546414001692	Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772
546414001693	GTP-binding protein YchF; Reviewed; Region: PRK09601
546414001694	YchF GTPase; Region: YchF; cd01900
546414001695	G1 box; other site
546414001696	GTP/Mg2+ binding site [chemical binding]; other site
546414001697	Switch I region; other site
546414001698	G2 box; other site
546414001699	Switch II region; other site
546414001700	G3 box; other site
546414001701	G4 box; other site
546414001702	G5 box; other site
546414001703	The TGS domain, named after the ThrRS, GTPase, and SpoT/RelA proteins where it occurs, is structurally similar to ubiquitin. TGS is a small domain of about 50 amino acid residues with a predominantly beta-sheet structure. There is no direct information...; Region: TGS; cl15768
546414001704	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
546414001705	Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714
546414001706	tetramer interface [polypeptide binding]; other site
546414001707	active site
546414001708	Mg2+/Mn2+ binding site [ion binding]; other site
546414001709	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07666
546414001710	classical (c) SDRs; Region: SDR_c; cd05233
546414001711	NAD(P) binding site [chemical binding]; other site
546414001712	active site
546414001713	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
546414001714	Predicted membrane protein [Function unknown]; Region: COG2364
546414001715	GMP synthase; Reviewed; Region: guaA; PRK00074
546414001716	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
546414001717	AMP/PPi binding site [chemical binding]; other site
546414001718	candidate oxyanion hole; other site
546414001719	catalytic triad [active]
546414001720	potential glutamine specificity residues [chemical binding]; other site
546414001721	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
546414001722	ATP Binding subdomain [chemical binding]; other site
546414001723	Ligand Binding sites [chemical binding]; other site
546414001724	Dimerization subdomain; other site
546414001725	antiporter inner membrane protein; Provisional; Region: PRK11670
546414001726	Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151
546414001727	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
546414001728	Predicted transcriptional regulator [Transcription]; Region: COG2345
546414001729	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
546414001730	putative DNA binding site [nucleotide binding]; other site
546414001731	putative Zn2+ binding site [ion binding]; other site
546414001732	2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563
546414001733	bifunctional 3-deoxy-7-phosphoheptulonate synthase/chorismate mutase; Reviewed; Region: PRK12595
546414001734	Chorismate mutase type II; Region: CM_2; cl00693
546414001735	phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361
546414001736	Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454
546414001737	apolar tunnel; other site
546414001738	heme binding site [chemical binding]; other site
546414001739	dimerization interface [polypeptide binding]; other site
546414001740	Uncharacterized ACR, COG1678; Region: DUF179; cl00731
546414001741	ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466
546414001742	Found in ATP-dependent protease La (LON); Region: LON; smart00464
546414001743	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
546414001744	Walker A motif; other site
546414001745	ATP binding site [chemical binding]; other site
546414001746	Walker B motif; other site
546414001747	arginine finger; other site
546414001748	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
546414001749	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
546414001750	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
546414001751	active site
546414001752	trigger factor; Region: tig; TIGR00115
546414001753	ASC-1 homology or ASCH domain, a small beta-barrel domain found in all three kingdoms of life. ASCH resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as an RNA-binding domain during coactivation; Region: ASCH; cl01020
546414001754	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
546414001755	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
546414001756	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
546414001757	dimer interface [polypeptide binding]; other site
546414001758	active site
546414001759	CoA binding pocket [chemical binding]; other site
546414001760	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
546414001761	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
546414001762	DinB superfamily; Region: DinB_2; pfam12867
546414001763	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
546414001764	3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830
546414001765	NAD(P) binding site [chemical binding]; other site
546414001766	homotetramer interface [polypeptide binding]; other site
546414001767	homodimer interface [polypeptide binding]; other site
546414001768	active site
546414001769	acyl carrier protein; Provisional; Region: acpP; PRK00982
546414001770	beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150
546414001771	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
546414001772	dimer interface [polypeptide binding]; other site
546414001773	active site
546414001774	large tegument protein UL36; Provisional; Region: PHA03247
546414001775	polyphosphate kinase; Provisional; Region: PRK05443
546414001776	Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089
546414001777	Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503
546414001778	Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165
546414001779	putative domain interface [polypeptide binding]; other site
546414001780	putative active site [active]
546414001781	catalytic site [active]
546414001782	Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168
546414001783	putative domain interface [polypeptide binding]; other site
546414001784	putative active site [active]
546414001785	catalytic site [active]
546414001786	30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676
546414001787	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
546414001788	RNA binding site [nucleotide binding]; other site
546414001789	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
546414001790	RNA binding site [nucleotide binding]; other site
546414001791	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
546414001792	RNA binding site [nucleotide binding]; other site
546414001793	S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec5; cd05690
546414001794	RNA binding site [nucleotide binding]; other site
546414001795	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
546414001796	RNA binding site [nucleotide binding]; other site
546414001797	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
546414001798	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
546414001799	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
546414001800	FKBP-type peptidyl-prolyl cis-trans isomerases 2 [Posttranslational modification, protein turnover, chaperones]; Region: SlpA; COG1047
546414001801	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
546414001802	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
546414001803	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
546414001804	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
546414001805	dimer interface [polypeptide binding]; other site
546414001806	putative functional site; other site
546414001807	putative MPT binding site; other site
546414001808	Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338
546414001809	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
546414001810	active site
546414001811	homodimer interface [polypeptide binding]; other site
546414001812	catalytic site [active]
546414001813	RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966
546414001814	metal binding triad [ion binding]; metal-binding site
546414001815	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
546414001816	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
546414001817	Zn2+ binding site [ion binding]; other site
546414001818	Mg2+ binding site [ion binding]; other site
546414001819	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
546414001820	GAF domain; Region: GAF; pfam01590
546414001821	Predicted transcriptional regulators [Transcription]; Region: COG1378
546414001822	Sugar-specific transcriptional regulator TrmB; Region: TrmB; pfam01978
546414001823	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
546414001824	catalytic site [active]
546414001825	prolyl-tRNA synthetase; Provisional; Region: PRK08661
546414001826	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_arch_euk; cd00778
546414001827	dimer interface [polypeptide binding]; other site
546414001828	motif 1; other site
546414001829	active site
546414001830	motif 2; other site
546414001831	motif 3; other site
546414001832	ProRS Prolyl-anticodon binding domain, long version found predominantly in eukaryotes and archaea. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in...; Region: ProRS_anticodon_zinc; cd00862
546414001833	anticodon binding site; other site
546414001834	zinc-binding site [ion binding]; other site
546414001835	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
546414001836	active site
546414001837	NTP binding site [chemical binding]; other site
546414001838	metal binding triad [ion binding]; metal-binding site
546414001839	antibiotic binding site [chemical binding]; other site
546414001840	Alpha amylase catalytic domain found in Amylosucrase; Region: AmyAc_Amylosucrase; cd11324
546414001841	trehalose synthase; Region: treS_nterm; TIGR02456
546414001842	active site
546414001843	catalytic site [active]
546414001844	50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172
546414001845	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
546414001846	23S rRNA binding site [nucleotide binding]; other site
546414001847	L21 binding site [polypeptide binding]; other site
546414001848	L13 binding site [polypeptide binding]; other site
546414001849	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
546414001850	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
546414001851	DNA-binding site [nucleotide binding]; DNA binding site
546414001852	UTRA domain; Region: UTRA; pfam07702
546414001853	molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164
546414001854	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
546414001855	FeS/SAM binding site; other site
546414001856	Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463
546414001857	Protein of unknown function, DUF485; Region: DUF485; cl01231
546414001858	Predicted symporter [General function prediction only]; Region: DhlC; COG4147
546414001859	Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480
546414001860	Na binding site [ion binding]; other site
546414001861	DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847
546414001862	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
546414001863	active site
546414001864	catalytic site [active]
546414001865	substrate binding site [chemical binding]; other site
546414001866	Predicted signal-transduction protein containing cAMP-binding and CBS domains [Signal transduction mechanisms]; Region: COG2905
546414001867	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
546414001868	ligand binding site [chemical binding]; other site
546414001869	flexible hinge region; other site
546414001870	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with either the CAP_ED (cAMP receptor protein effector domain) family of transcription factors and the DUF294 domain or the PB1 (Phox and Bem1p) domain; Region: CBS_pair_CAP-ED_DUF294_PBI_assoc2; cd04800
546414001871	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
546414001872	metal binding triad; other site
546414001873	acetyl-CoA synthetase; Provisional; Region: PRK00174
546414001874	Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966
546414001875	active site
546414001876	CoA binding site [chemical binding]; other site
546414001877	acyl-activating enzyme (AAE) consensus motif; other site
546414001878	AMP binding site [chemical binding]; other site
546414001879	acetate binding site [chemical binding]; other site
546414001880	succinyldiaminopimelate transaminase; Validated; Region: PRK07366
546414001881	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
546414001882	pyridoxal 5'-phosphate binding site [chemical binding]; other site
546414001883	homodimer interface [polypeptide binding]; other site
546414001884	catalytic residue [active]
546414001885	Protein of unknown function (DUF2721); Region: DUF2721; pfam11026
546414001886	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
546414001887	DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566
546414001888	RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663
546414001889	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
546414001890	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
546414001891	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
546414001892	Rpb1 - Rpb6 interaction site [polypeptide binding]; other site
546414001893	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
546414001894	DNA binding site [nucleotide binding]
546414001895	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
546414001896	DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405
546414001897	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
546414001898	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
546414001899	RPB12 interaction site [polypeptide binding]; other site
546414001900	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
546414001901	RPB10 interaction site [polypeptide binding]; other site
546414001902	RPB1 interaction site [polypeptide binding]; other site
546414001903	RPB11 interaction site [polypeptide binding]; other site
546414001904	RPB3 interaction site [polypeptide binding]; other site
546414001905	RPB12 interaction site [polypeptide binding]; other site
546414001906	Uncharacterized protein conserved in bacteria containing a divergent form of TPR repeats [Function unknown]; Region: COG4700
546414001907	Uncharacterized protein conserved in bacteria (DUF2239); Region: DUF2239; cl01461
546414001908	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
546414001909	peripheral dimer interface [polypeptide binding]; other site
546414001910	core dimer interface [polypeptide binding]; other site
546414001911	L10 interface [polypeptide binding]; other site
546414001912	L11 interface [polypeptide binding]; other site
546414001913	putative EF-Tu interaction site [polypeptide binding]; other site
546414001914	putative EF-G interaction site [polypeptide binding]; other site
546414001915	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
546414001916	23S rRNA interface [nucleotide binding]; other site
546414001917	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
546414001918	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
546414001919	mRNA/rRNA interface [nucleotide binding]; other site
546414001920	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
546414001921	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
546414001922	23S rRNA interface [nucleotide binding]; other site
546414001923	L7/L12 interface [polypeptide binding]; other site
546414001924	putative thiostrepton binding site; other site
546414001925	L25 interface [polypeptide binding]; other site
546414001926	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
546414001927	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
546414001928	putative homodimer interface [polypeptide binding]; other site
546414001929	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
546414001930	heterodimer interface [polypeptide binding]; other site
546414001931	homodimer interface [polypeptide binding]; other site
546414001932	preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597
546414001933	50S ribosomal protein L33; Validated; Region: rpmG; PRK00595
546414001934	elongation factor Tu; Reviewed; Region: PRK00049
546414001935	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
546414001936	G1 box; other site
546414001937	GEF interaction site [polypeptide binding]; other site
546414001938	GTP/Mg2+ binding site [chemical binding]; other site
546414001939	Switch I region; other site
546414001940	G2 box; other site
546414001941	G3 box; other site
546414001942	Switch II region; other site
546414001943	G4 box; other site
546414001944	G5 box; other site
546414001945	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
546414001946	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
546414001947	Antibiotic Binding Site [chemical binding]; other site
546414001948	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
546414001949	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
546414001950	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
546414001951	Walker A/P-loop; other site
546414001952	ATP binding site [chemical binding]; other site
546414001953	Q-loop/lid; other site
546414001954	ABC transporter signature motif; other site
546414001955	Walker B; other site
546414001956	D-loop; other site
546414001957	H-loop/switch region; other site
546414001958	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
546414001959	ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265
546414001960	ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254
546414001961	Walker A/P-loop; other site
546414001962	ATP binding site [chemical binding]; other site
546414001963	Q-loop/lid; other site
546414001964	ABC transporter signature motif; other site
546414001965	Walker B; other site
546414001966	D-loop; other site
546414001967	H-loop/switch region; other site
546414001968	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
546414001969	Glycoprotease family; Region: Peptidase_M22; pfam00814
546414001970	Citrate synthase (CS) catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the oxidative citric acid cycle (TCA or Krebs cycle). Peroxisomal CS is involved in the glyoxylate...; Region: citrate_synt_like_1; cd06118
546414001971	dimer interface [polypeptide binding]; other site
546414001972	Citrate synthase; Region: Citrate_synt; pfam00285
546414001973	active site
546414001974	coenzyme A binding site [chemical binding]; other site
546414001975	citrylCoA binding site [chemical binding]; other site
546414001976	oxalacetate/citrate binding site [chemical binding]; other site
546414001977	catalytic triad [active]
546414001978	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
546414001979	PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493
546414001980	Trp docking motif [polypeptide binding]; other site
546414001981	active site
546414001982	PQQ-like domain; Region: PQQ_2; pfam13360
546414001983	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
546414001984	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
546414001985	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933
546414001986	FMN binding site [chemical binding]; other site
546414001987	active site
546414001988	substrate binding site [chemical binding]; other site
546414001989	catalytic residue [active]
546414001990	inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567
546414001991	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
546414001992	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein.  IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601
546414001993	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
546414001994	active site
546414001995	Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272
546414001996	channel protein, hemolysin III family; Region: hlyIII; TIGR01065
546414001997	Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158
546414001998	Peptidase family M50; Region: Peptidase_M50; pfam02163
546414001999	active site
546414002000	putative substrate binding region [chemical binding]; other site
546414002001	tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617
546414002002	RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966
546414002003	metal binding triad [ion binding]; metal-binding site
546414002004	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
546414002005	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
546414002006	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
546414002007	Heat shock protein 33 (Hsp33):  Cytosolic protein that acts as a molecular chaperone under oxidative conditions.  In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498
546414002008	Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114
546414002009	dimerization interface [polypeptide binding]; other site
546414002010	domain crossover interface; other site
546414002011	redox-dependent activation switch; other site
546414002012	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
546414002013	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512
546414002014	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
546414002015	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
546414002016	active site
546414002017	phosphorylation site [posttranslational modification]
546414002018	intermolecular recognition site; other site
546414002019	dimerization interface [polypeptide binding]; other site
546414002020	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
546414002021	DNA binding residues [nucleotide binding]
546414002022	dimerization interface [polypeptide binding]; other site
546414002023	GAF domain; Region: GAF; pfam01590
546414002024	GAF domain; Region: GAF_3; pfam13492
546414002025	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
546414002026	PAS domain; Region: PAS_9; pfam13426
546414002027	putative active site [active]
546414002028	heme pocket [chemical binding]; other site
546414002029	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
546414002030	Histidine kinase; Region: HisKA_3; pfam07730
546414002031	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
546414002032	ATP binding site [chemical binding]; other site
546414002033	Mg2+ binding site [ion binding]; other site
546414002034	G-X-G motif; other site
546414002035	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
546414002036	This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1; Region: GT1_UGDG_like; cd03817
546414002037	putative ADP-binding pocket [chemical binding]; other site
546414002038	transferase 2, rSAM/selenodomain-associated; Region: glyco_like_mftF; TIGR04283
546414002039	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
546414002040	active site
546414002041	Major Facilitator Superfamily; Region: MFS_1; pfam07690
546414002042	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
546414002043	Major Facilitator Superfamily; Region: MFS_1; pfam07690
546414002044	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
546414002045	Catalytic NodB homology domain of uncharacterized bacterial polysaccharide deacetylases; Region: CE4_NodB_like_3; cd10959
546414002046	NodB motif; other site
546414002047	putative active site [active]
546414002048	putative catalytic site [active]
546414002049	putative Zn binding site [ion binding]; other site
546414002050	recombination protein RecR; Reviewed; Region: recR; PRK00076
546414002051	RecR protein; Region: RecR; pfam02132
546414002052	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
546414002053	putative active site [active]
546414002054	putative metal-binding site [ion binding]; other site
546414002055	tetramer interface [polypeptide binding]; other site
546414002056	hypothetical protein; Validated; Region: PRK00153
546414002057	ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051
546414002058	nudix motif; other site
546414002059	Uncharacterized conserved protein [General function prediction only]; Region: COG4111
546414002060	Glycogen debranching enzyme N terminal; Region: GDE_N; pfam12439
546414002061	Glycogen debranching enzyme [Carbohydrate transport and metabolism]; Region: GDB1; COG3408
546414002062	Amylo-alpha-1,6-glucosidase; Region: GDE_C; pfam06202
546414002063	translation initiation factor IF-3; Reviewed; Region: infC; PRK00028
546414002064	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
546414002065	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
546414002066	NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976
546414002067	catalytic residues [active]
546414002068	Homo sapiens acid phosphatase 5 and related proteins, metallophosphatase domain; Region: MPP_ACP5; cd07378
546414002069	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
546414002070	active site
546414002071	metal binding site [ion binding]; metal-binding site
546414002072	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413
546414002073	TGS _ThrRS_N:  ThrRS (threonyl-tRNA Synthetase)  is a class II tRNA synthetase that couples threonine to its cognate tRNA.  In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667
546414002074	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
546414002075	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
546414002076	active site
546414002077	dimer interface [polypeptide binding]; other site
546414002078	motif 1; other site
546414002079	motif 2; other site
546414002080	motif 3; other site
546414002081	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
546414002082	anticodon binding site; other site
546414002083	Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651
546414002084	Thioredoxin; Region: Thioredoxin_4; cl17273
546414002085	Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075
546414002086	Lipase (class 2); Region: Lipase_2; pfam01674
546414002087	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
546414002088	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
546414002089	active site
546414002090	Int/Topo IB signature motif; other site
546414002091	DNA binding site [nucleotide binding]
546414002092	Helix-turn-helix domain; Region: HTH_17; pfam12728
546414002093	N-terminal putative catalytic domain of uncharacterized prokaryotic and archeal HKD family nucleases fused to a DEAD/DEAH box helicase domain; Region: PLDc_N_DEXD_a; cd09179
546414002094	PLD-like domain; Region: PLDc_2; pfam13091
546414002095	putative active site [active]
546414002096	catalytic site [active]
546414002097	DEAD-like helicases superfamily; Region: DEXDc; smart00487
546414002098	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
546414002099	ATP binding site [chemical binding]; other site
546414002100	putative Mg++ binding site [ion binding]; other site
546414002101	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
546414002102	nucleotide binding region [chemical binding]; other site
546414002103	ATP-binding site [chemical binding]; other site
546414002104	Protein of unknown function (DUF1156); Region: DUF1156; pfam06634
546414002105	Adenine-specific DNA methylase containing a Zn-ribbon [DNA replication, recombination, and repair]; Region: COG1743
546414002106	Protein of unknown function (DUF1156); Region: DUF1156; pfam06634
546414002107	Adenine-specific DNA methylase containing a Zn-ribbon [DNA replication, recombination, and repair]; Region: COG1743
546414002108	Protein of unknown function (DUF3780); Region: DUF3780; pfam12635
546414002109	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1483
546414002110	Protein of unknown function (DUF499); Region: DUF499; pfam04465
546414002111	Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101
546414002112	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
546414002113	active site
546414002114	catalytic site [active]
546414002115	substrate binding site [chemical binding]; other site
546414002116	Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199
546414002117	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
546414002118	ATP binding site [chemical binding]; other site
546414002119	DEAD_2; Region: DEAD_2; pfam06733
546414002120	Helicase C-terminal domain; Region: Helicase_C_2; pfam13307
546414002121	DEAD-like helicases superfamily; Region: DEXDc; smart00487
546414002122	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
546414002123	ATP binding site [chemical binding]; other site
546414002124	putative Mg++ binding site [ion binding]; other site
546414002125	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
546414002126	nucleotide binding region [chemical binding]; other site
546414002127	ATP-binding site [chemical binding]; other site
546414002128	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
546414002129	Part of AAA domain; Region: AAA_19; pfam13245
546414002130	Family description; Region: UvrD_C_2; pfam13538
546414002131	SIR2-like domain; Region: SIR2_2; pfam13289
546414002132	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
546414002133	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
546414002134	Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165
546414002135	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544
546414002136	Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165
546414002137	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544
546414002138	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544
546414002139	CHASE3 domain; Region: CHASE3; pfam05227
546414002140	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
546414002141	dimerization interface [polypeptide binding]; other site
546414002142	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
546414002143	PAS domain; Region: PAS_9; pfam13426
546414002144	putative active site [active]
546414002145	heme pocket [chemical binding]; other site
546414002146	PAS domain; Region: PAS_9; pfam13426
546414002147	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
546414002148	dimer interface [polypeptide binding]; other site
546414002149	phosphorylation site [posttranslational modification]
546414002150	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
546414002151	ATP binding site [chemical binding]; other site
546414002152	Mg2+ binding site [ion binding]; other site
546414002153	G-X-G motif; other site
546414002154	pyridoxamine-phosphate oxidase; Region: pdxH; TIGR00558
546414002155	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
546414002156	Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590
546414002157	2-phosphoglycerate kinase; Provisional; Region: PRK12337
546414002158	Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396
546414002159	nucleophile elbow; other site
546414002160	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
546414002161	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
546414002162	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
546414002163	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
546414002164	nucleotide binding site [chemical binding]; other site
546414002165	Sporulation control protein [General function prediction only]; Region: Spo0M; COG4326
546414002166	SpoOM protein; Region: Spo0M; pfam07070
546414002167	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
546414002168	Cytosine deaminase and related metal-dependent hydrolases [Nucleotide transport and metabolism / General function prediction only]; Region: SsnA; COG0402
546414002169	active site
546414002170	thymidine kinase; Provisional; Region: PRK04296
546414002171	50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00528
546414002172	ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; cl00614
546414002173	Domain of unknown function (DUF4388); Region: DUF4388; pfam14332
546414002174	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
546414002175	nudix motif; other site
546414002176	valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729
546414002177	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
546414002178	HIGH motif; other site
546414002179	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
546414002180	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
546414002181	active site
546414002182	KMSKS motif; other site
546414002183	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
546414002184	tRNA binding surface [nucleotide binding]; other site
546414002185	anticodon binding site; other site
546414002186	Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458
546414002187	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215
546414002188	Zn2+ binding site [ion binding]; other site
546414002189	Mg2+ binding site [ion binding]; other site
546414002190	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
546414002191	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
546414002192	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
546414002193	catalytic residue [active]
546414002194	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815
546414002195	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
546414002196	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
546414002197	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
546414002198	Branched-chain amino acid transport protein (AzlD); Region: AzlD; cl00735
546414002199	AzlC protein; Region: AzlC; cl00570
546414002200	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
546414002201	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
546414002202	catalytic core [active]
546414002203	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
546414002204	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
546414002205	Uncharacterized conserved protein [Function unknown]; Region: COG4104
546414002206	Domain of unknown function (DUF4157); Region: DUF4157; pfam13699
546414002207	T4-like virus tail tube protein gp19; Region: Phage_T4_gp19; pfam06841
546414002208	T4-like virus tail tube protein gp19; Region: Phage_T4_gp19; pfam06841
546414002209	Phage tail sheath protein; Region: Phage_sheath_1; cl01389
546414002210	Phage tail sheath protein FI [General function prediction only]; Region: COG3497
546414002211	Protein of unknown function (DUF4255); Region: DUF4255; pfam14065
546414002212	Gene 25-like lysozyme; Region: GPW_gp25; pfam04965
546414002213	conserved hypothetical protein, phage tail-like region; Region: TIGR02243
546414002214	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
546414002215	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
546414002216	phosphopeptide binding site; other site
546414002217	phage tail protein domain; Region: tail_TIGR02242
546414002218	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
546414002219	Catalytic domain of Protein Kinases; Region: PKc; cd00180
546414002220	active site
546414002221	ATP binding site [chemical binding]; other site
546414002222	substrate binding site [chemical binding]; other site
546414002223	activation loop (A-loop); other site
546414002224	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
546414002225	phosphopeptide binding site; other site
546414002226	Rhs element Vgr protein; Region: vgr_GE; TIGR01646
546414002227	Phage protein D [General function prediction only]; Region: COG3500
546414002228	Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717
546414002229	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
546414002230	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
546414002231	Walker A motif; other site
546414002232	ATP binding site [chemical binding]; other site
546414002233	Walker B motif; other site
546414002234	arginine finger; other site
546414002235	Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197
546414002236	CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; pfam02559
546414002237	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
546414002238	ATP binding site [chemical binding]; other site
546414002239	putative Mg++ binding site [ion binding]; other site
546414002240	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
546414002241	nucleotide binding region [chemical binding]; other site
546414002242	ATP-binding site [chemical binding]; other site
546414002243	TRCF domain; Region: TRCF; pfam03461
546414002244	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
546414002245	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
546414002246	Coenzyme A binding pocket [chemical binding]; other site
546414002247	Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956
546414002248	PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877
546414002249	putative active site [active]
546414002250	Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237
546414002251	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
546414002252	CoA-binding site [chemical binding]; other site
546414002253	ATP-binding [chemical binding]; other site
546414002254	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
546414002255	binding surface
546414002256	TPR repeat; Region: TPR_11; pfam13414
546414002257	TPR motif; other site
546414002258	TPR repeat; Region: TPR_11; pfam13414
546414002259	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
546414002260	binding surface
546414002261	TPR motif; other site
546414002262	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
546414002263	TPR motif; other site
546414002264	TPR repeat; Region: TPR_11; pfam13414
546414002265	binding surface
546414002266	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
546414002267	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
546414002268	Walker A/P-loop; other site
546414002269	ATP binding site [chemical binding]; other site
546414002270	Q-loop/lid; other site
546414002271	ABC transporter signature motif; other site
546414002272	Walker B; other site
546414002273	D-loop; other site
546414002274	H-loop/switch region; other site
546414002275	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
546414002276	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
546414002277	Walker A/P-loop; other site
546414002278	ATP binding site [chemical binding]; other site
546414002279	Q-loop/lid; other site
546414002280	ABC transporter signature motif; other site
546414002281	Walker B; other site
546414002282	D-loop; other site
546414002283	H-loop/switch region; other site
546414002284	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
546414002285	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
546414002286	TM-ABC transporter signature motif; other site
546414002287	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
546414002288	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
546414002289	TM-ABC transporter signature motif; other site
546414002290	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
546414002291	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
546414002292	DNA polymerase IV (family X) [DNA replication, recombination, and repair]; Region: POL4; COG1796
546414002293	RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966
546414002294	metal binding triad [ion binding]; metal-binding site
546414002295	Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436
546414002296	Histidinol phosphatase and related hydrolases of the PHP family [Amino acid transport and metabolism / General function prediction only]; Region: HIS2; COG1387
546414002297	active site
546414002298	histidinol-phosphatase; Provisional; Region: PRK07328
546414002299	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase of Hisj like; Region: PHP_HisPPase_Hisj_like; cd12110
546414002300	active site
546414002301	dimer interface [polypeptide binding]; other site
546414002302	O-acetylserine/cysteine export protein; Provisional; Region: PRK11453
546414002303	EamA-like transporter family; Region: EamA; pfam00892
546414002304	ornithine carbamoyltransferase; Provisional; Region: PRK00779
546414002305	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
546414002306	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
546414002307	isopentenyl-diphosphate delta-isomerase, type 1; Region: IPP_isom_1; TIGR02150
546414002308	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883
546414002309	nudix motif; other site
546414002310	N-acetyl-gamma-glutamyl-phosphate reductase; Provisional; Region: PRK11863
546414002311	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
546414002312	Rec8/ScpA/Scc1-like protein (kleisin family) [Replication,    recombination, and repair]; Region: scpA; COG1354
546414002313	tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282
546414002314	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
546414002315	active site
546414002316	HIGH motif; other site
546414002317	dimer interface [polypeptide binding]; other site
546414002318	KMSKS motif; other site
546414002319	peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059
546414002320	PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145
546414002321	PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145
546414002322	The members of this protein family contain the SIS (Sugar ISomerase) domain and have both the phosphoglucose isomerase (PGI) and the phosphomannose isomerase (PMI) functions. These functions catalyze the reversible reactions of glucose 6-phosphate to...; Region: SIS_PGI_PMI_2; cd05637
546414002323	dimer interface [polypeptide binding]; other site
546414002324	active site
546414002325	single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644
546414002326	DHH family; Region: DHH; pfam01368
546414002327	DHHA1 domain; Region: DHHA1; pfam02272
546414002328	S-layer homology domain; Region: SLH; pfam00395
546414002329	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505
546414002330	3-hydroxybutyryl-CoA dehydratase; Validated; Region: PRK05809
546414002331	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
546414002332	substrate binding site [chemical binding]; other site
546414002333	oxyanion hole (OAH) forming residues; other site
546414002334	trimer interface [polypeptide binding]; other site
546414002335	2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766
546414002336	HD supefamily hydrolase [General function prediction only]; Region: COG3294
546414002337	transcription elongation factor GreA; Region: greA; TIGR01462
546414002338	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
546414002339	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
546414002340	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
546414002341	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
546414002342	ABC-ATPase subunit  interface; other site
546414002343	dimer interface [polypeptide binding]; other site
546414002344	putative PBP binding regions; other site
546414002345	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
546414002346	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
546414002347	lipoyl synthase; Provisional; Region: PRK05481
546414002348	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
546414002349	FeS/SAM binding site; other site
546414002350	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057
546414002351	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
546414002352	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
546414002353	Coenzyme A binding pocket [chemical binding]; other site
546414002354	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
546414002355	acetolactate synthase 3 catalytic subunit; Validated; Region: PRK07979
546414002356	50S ribosomal protein L19; Provisional; Region: rplS; PRK05338
546414002357	Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561
546414002358	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
546414002359	cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166
546414002360	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
546414002361	Walker A/P-loop; other site
546414002362	ATP binding site [chemical binding]; other site
546414002363	Q-loop/lid; other site
546414002364	ABC transporter signature motif; other site
546414002365	Walker B; other site
546414002366	D-loop; other site
546414002367	H-loop/switch region; other site
546414002368	ABC-type molybdenum transport system, ATPase component/photorepair protein PhrA [Inorganic ion transport and metabolism]; Region: ModF; COG1119
546414002369	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
546414002370	Walker A/P-loop; other site
546414002371	ATP binding site [chemical binding]; other site
546414002372	Q-loop/lid; other site
546414002373	ABC transporter signature motif; other site
546414002374	Walker B; other site
546414002375	D-loop; other site
546414002376	H-loop/switch region; other site
546414002377	Histidine phosphatase superfamily (branch 1); Region: His_Phos_1; pfam00300
546414002378	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
546414002379	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
546414002380	Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403
546414002381	Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585
546414002382	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3224
546414002383	30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132
546414002384	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
546414002385	23S rRNA interface [nucleotide binding]; other site
546414002386	L3 interface [polypeptide binding]; other site
546414002387	ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803
546414002388	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
546414002389	intersubunit interface [polypeptide binding]; other site
546414002390	50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359
546414002391	trehalose synthase; Region: treS_nterm; TIGR02456
546414002392	Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334
546414002393	active site
546414002394	catalytic site [active]
546414002395	Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516
546414002396	Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320
546414002397	putative active site [active]
546414002398	phosphoglucomutase; Validated; Region: PRK07564
546414002399	This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801
546414002400	active site
546414002401	substrate binding site [chemical binding]; other site
546414002402	metal binding site [ion binding]; metal-binding site
546414002403	MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123
546414002404	MviN-like protein; Region: MVIN; pfam03023
546414002405	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cl00630
546414002406	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
546414002407	putative active site [active]
546414002408	DNA topoisomerase I subunit omega; Validated; Region: PRK07561
546414002409	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363
546414002410	active site
546414002411	interdomain interaction site; other site
546414002412	putative metal-binding site [ion binding]; other site
546414002413	nucleotide binding site [chemical binding]; other site
546414002414	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
546414002415	domain I; other site
546414002416	DNA binding groove [nucleotide binding]
546414002417	phosphate binding site [ion binding]; other site
546414002418	domain II; other site
546414002419	domain III; other site
546414002420	nucleotide binding site [chemical binding]; other site
546414002421	catalytic site [active]
546414002422	domain IV; other site
546414002423	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
546414002424	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
546414002425	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
546414002426	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812
546414002427	hydrophobic ligand binding site; other site
546414002428	Uncharacterized proteins, LmbE homologs [Function unknown]; Region: COG2120
546414002429	Tic20-like protein; Region: Tic20; pfam09685
546414002430	RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278
546414002431	RNA/DNA hybrid binding site [nucleotide binding]; other site
546414002432	active site
546414002433	H+ Antiporter protein; Region: 2A0121; TIGR00900
546414002434	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883
546414002435	nudix motif; other site
546414002436	bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14358
546414002437	N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540
546414002438	Substrate binding site; other site
546414002439	Mg++ binding site; other site
546414002440	N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353
546414002441	active site
546414002442	substrate binding site [chemical binding]; other site
546414002443	CoA binding site [chemical binding]; other site
546414002444	Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478
546414002445	Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805
546414002446	twin arginine translocase protein A; Provisional; Region: tatA; PRK00575
546414002447	twin arginine-targeting protein translocase, TatA/E family; Region: tatAE; TIGR01411
546414002448	twin arginine translocase protein A; Provisional; Region: tatA; PRK14861
546414002449	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
546414002450	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
546414002451	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
546414002452	DNA binding residues [nucleotide binding]
546414002453	putative anti-sigmaE protein; Provisional; Region: PRK13920
546414002454	Anti-sigma-K factor rskA; Region: RskA; pfam10099
546414002455	Ferritin-like domain; Region: Ferritin_2; pfam13668
546414002456	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
546414002457	putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344
546414002458	putative NAD(P) binding site [chemical binding]; other site
546414002459	putative active site [active]
546414002460	futalosine nucleosidase; Region: fut_nucase; TIGR03664
546414002461	L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396
546414002462	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
546414002463	NAD(P) binding site [chemical binding]; other site
546414002464	tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282
546414002465	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
546414002466	dimer interface [polypeptide binding]; other site
546414002467	active site
546414002468	KMSKS motif; other site
546414002469	chaperone protein DnaJ; Provisional; Region: PRK14292
546414002470	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
546414002471	HSP70 interaction site [polypeptide binding]; other site
546414002472	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
546414002473	Zn binding sites [ion binding]; other site
546414002474	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
546414002475	dimer interface [polypeptide binding]; other site
546414002476	Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233
546414002477	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
546414002478	META domain; Region: META; pfam03724
546414002479	META domain; Region: META; pfam03724
546414002480	ribose-phosphate pyrophosphokinase; Region: ribP_PPkin; TIGR01251
546414002481	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
546414002482	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
546414002483	active site
546414002484	Pantoate-beta-alanine ligase; Region: PanC; cd00560
546414002485	pantoate--beta-alanine ligase; Region: panC; TIGR00018
546414002486	active site
546414002487	ATP-binding site [chemical binding]; other site
546414002488	pantoate-binding site; other site
546414002489	HXXH motif; other site
546414002490	pilus retraction protein PilT; Region: pilT_fam; TIGR01420
546414002491	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
546414002492	Walker A motif; other site
546414002493	ATP binding site [chemical binding]; other site
546414002494	Walker B motif; other site
546414002495	Alpha amylase catalytic domain found in bacterial cyclomaltodextrinases and related proteins; Region: AmyAc_bac_CMD_like_2; cd11339
546414002496	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
546414002497	active site
546414002498	catalytic site [active]
546414002499	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
546414002500	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
546414002501	Walker A/P-loop; other site
546414002502	ATP binding site [chemical binding]; other site
546414002503	Q-loop/lid; other site
546414002504	ABC transporter signature motif; other site
546414002505	Walker B; other site
546414002506	D-loop; other site
546414002507	H-loop/switch region; other site
546414002508	TOBE domain; Region: TOBE; pfam03459
546414002509	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
546414002510	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
546414002511	substrate binding pocket [chemical binding]; other site
546414002512	membrane-bound complex binding site; other site
546414002513	hinge residues; other site
546414002514	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
546414002515	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
546414002516	dimer interface [polypeptide binding]; other site
546414002517	conserved gate region; other site
546414002518	putative PBP binding loops; other site
546414002519	ABC-ATPase subunit interface; other site
546414002520	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
546414002521	Domain of unknown function DUF20; Region: UPF0118; pfam01594
546414002522	TRAP-type uncharacterized transport system, fused permease components [General function prediction only]; Region: COG4666
546414002523	TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358
546414002524	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
546414002525	membrane-bound complex binding site; other site
546414002526	hinge residues; other site
546414002527	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
546414002528	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
546414002529	Walker A/P-loop; other site
546414002530	ATP binding site [chemical binding]; other site
546414002531	Q-loop/lid; other site
546414002532	ABC transporter signature motif; other site
546414002533	Walker B; other site
546414002534	D-loop; other site
546414002535	H-loop/switch region; other site
546414002536	Major Facilitator Superfamily; Region: MFS_1; pfam07690
546414002537	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
546414002538	CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400
546414002539	Cl- selectivity filter; other site
546414002540	Cl- binding residues [ion binding]; other site
546414002541	pore gating glutamate residue; other site
546414002542	superoxide dismutase; Provisional; Region: PRK10925
546414002543	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
546414002544	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
546414002545	Predicted heme peroxidase involved in anaerobic stress response [General function prediction only]; Region: ywfI; COG3253
546414002546	Acetoacetate decarboxylase (ADC); Region: ADC; cl01919
546414002547	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
546414002548	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
546414002549	active site
546414002550	metal binding site [ion binding]; metal-binding site
546414002551	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
546414002552	Domain of unknown function DUF20; Region: UPF0118; pfam01594
546414002553	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
546414002554	non-specific DNA binding site [nucleotide binding]; other site
546414002555	salt bridge; other site
546414002556	sequence-specific DNA binding site [nucleotide binding]; other site
546414002557	PEGA domain; Region: PEGA; pfam08308
546414002558	Domain of unknown function (DUF4115); Region: DUF4115; pfam13464
546414002559	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
546414002560	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
546414002561	TM-ABC transporter signature motif; other site
546414002562	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
546414002563	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
546414002564	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
546414002565	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
546414002566	TM-ABC transporter signature motif; other site
546414002567	Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413
546414002568	active site
546414002569	multimer interface [polypeptide binding]; other site
546414002570	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
546414002571	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
546414002572	metal binding site [ion binding]; metal-binding site
546414002573	active site
546414002574	I-site; other site
546414002575	Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer,  utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cd02062
546414002576	FMN binding site [chemical binding]; other site
546414002577	Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer,  utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cd02062
546414002578	dimer interface [polypeptide binding]; other site
546414002579	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
546414002580	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
546414002581	active site
546414002582	catalytic tetrad [active]
546414002583	Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424
546414002584	Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831
546414002585	malonyl-CoA binding site [chemical binding]; other site
546414002586	dimer interface [polypeptide binding]; other site
546414002587	active site
546414002588	product binding site; other site
546414002589	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
546414002590	CoA-transferase family III; Region: CoA_transf_3; pfam02515
546414002591	aconitate hydratase; Validated; Region: PRK09277
546414002592	Aconitase A catalytic domain; Region: AcnA_IRP; cd01586
546414002593	substrate binding site [chemical binding]; other site
546414002594	ligand binding site [chemical binding]; other site
546414002595	Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580
546414002596	substrate binding site [chemical binding]; other site
546414002597	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
546414002598	active site
546414002599	catalytic residues [active]
546414002600	L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948
546414002601	Muconate lactonizing enzyme (MLE) like subgroup of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and residues that can...; Region: MLE_like; cd03315
546414002602	active site
546414002603	PRC-barrel domain containing protein [General function prediction only]; Region: COG3881
546414002604	PRC-barrel domain; Region: PRC; pfam05239
546414002605	PRC-barrel domain; Region: PRC; pfam05239
546414002606	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
546414002607	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
546414002608	dimer interface [polypeptide binding]; other site
546414002609	pyridoxal 5'-phosphate binding site [chemical binding]; other site
546414002610	catalytic residue [active]
546414002611	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
546414002612	NAD(P) binding site [chemical binding]; other site
546414002613	active site
546414002614	Bacterial protein of unknown function (DUF937); Region: DUF937; cl01528
546414002615	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587
546414002616	ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496
546414002617	ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496
546414002618	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4586
546414002619	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
546414002620	Walker A/P-loop; other site
546414002621	ATP binding site [chemical binding]; other site
546414002622	Q-loop/lid; other site
546414002623	ABC transporter signature motif; other site
546414002624	Walker B; other site
546414002625	D-loop; other site
546414002626	H-loop/switch region; other site
546414002627	Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540
546414002628	active site
546414002629	DNA binding site [nucleotide binding]
546414002630	benzoate transport; Region: 2A0115; TIGR00895
546414002631	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
546414002632	putative substrate translocation pore; other site
546414002633	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
546414002634	nicotinate phosphoribosyltransferase; Validated; Region: PRK09243
546414002635	Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570
546414002636	active site
546414002637	bifunctional nicotinamide mononucleotide adenylyltransferase/ADP-ribose pyrophosphatase; Provisional; Region: PRK05379
546414002638	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
546414002639	active site
546414002640	nucleotide binding site [chemical binding]; other site
546414002641	HIGH motif; other site
546414002642	KMSKS motif; other site
546414002643	Ferritin-like domain; Region: Ferritin_2; pfam13668
546414002644	membrane ATPase/protein kinase; Provisional; Region: PRK09435
546414002645	The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114
546414002646	Walker A; other site
546414002647	methylmalonyl-CoA mutase; Reviewed; Region: PRK09426
546414002648	Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679
546414002649	active site
546414002650	substrate binding site [chemical binding]; other site
546414002651	coenzyme B12 binding site [chemical binding]; other site
546414002652	methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071
546414002653	B12 binding site [chemical binding]; other site
546414002654	cobalt ligand [ion binding]; other site
546414002655	Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036
546414002656	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
546414002657	substrate binding site [chemical binding]; other site
546414002658	hexamer interface [polypeptide binding]; other site
546414002659	metal binding site [ion binding]; metal-binding site
546414002660	2-phosphosulfolactate phosphatase; Provisional; Region: PRK14100
546414002661	2-phosphosulpholactate phosphatase; Region: 2-ph_phosp; pfam04029
546414002662	Domain of unknown function (DUF1795); Region: DUF1795; cl02256
546414002663	carboxynorspermidine decarboxylase; Region: nspC; TIGR01047
546414002664	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Carboxynorspermidine Decarboxylase; Region: PLPDE_III_CANSDC; cd06829
546414002665	dimer interface [polypeptide binding]; other site
546414002666	active site
546414002667	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
546414002668	catalytic residues [active]
546414002669	substrate binding site [chemical binding]; other site
546414002670	Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479
546414002671	Domain of unknown function (DUF4384); Region: DUF4384; pfam14326
546414002672	Helix-turn-helix domain; Region: HTH_17; pfam12728
546414002673	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
546414002674	Cytochrome P450; Region: p450; cl12078
546414002675	DivIVA protein; Region: DivIVA; pfam05103
546414002676	DivIVA domain; Region: DivI1A_domain; TIGR03544
546414002677	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635
546414002678	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
546414002679	catalytic residue [active]
546414002680	Outer membrane protein/protective antigen OMA87 [Cell envelope biogenesis, outer membrane]; Region: COG4775
546414002681	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
546414002682	POTRA domain, ShlB-type; Region: POTRA_2; pfam08479
546414002683	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
546414002684	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
546414002685	Surface antigen; Region: Bac_surface_Ag; pfam01103
546414002686	Predicted RNA-binding protein homologous to eukaryotic snRNP [Transcription]; Region: COG1293
546414002687	Domain of unknown function (DUF814); Region: DUF814; pfam05670
546414002688	Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent  decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919
546414002689	tetramerization interface [polypeptide binding]; other site
546414002690	active site
546414002691	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
546414002692	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
546414002693	Zn2+ binding site [ion binding]; other site
546414002694	Mg2+ binding site [ion binding]; other site
546414002695	Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167
546414002696	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
546414002697	putative substrate binding site [chemical binding]; other site
546414002698	putative ATP binding site [chemical binding]; other site
546414002699	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
546414002700	Coenzyme A binding pocket [chemical binding]; other site
546414002701	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
546414002702	iron-sulfur cluster [ion binding]; other site
546414002703	[2Fe-2S] cluster binding site [ion binding]; other site
546414002704	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
546414002705	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
546414002706	Cytochrome C biogenesis protein; Region: CcmH; pfam03918
546414002707	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
546414002708	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
546414002709	catalytic residues [active]
546414002710	Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: CcmF; COG1138
546414002711	cytochrome c-type biogenesis protein CcmE; Reviewed; Region: PRK13254
546414002712	Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504
546414002713	CcmB protein; Region: CcmB; cl17444
546414002714	Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884
546414002715	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
546414002716	Walker A/P-loop; other site
546414002717	ATP binding site [chemical binding]; other site
546414002718	Q-loop/lid; other site
546414002719	ABC transporter signature motif; other site
546414002720	Walker B; other site
546414002721	D-loop; other site
546414002722	H-loop/switch region; other site
546414002723	Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785
546414002724	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788
546414002725	Transglycosylase; Region: Transgly; pfam00912
546414002726	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
546414002727	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
546414002728	Response regulator receiver domain; Region: Response_reg; pfam00072
546414002729	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
546414002730	active site
546414002731	phosphorylation site [posttranslational modification]
546414002732	intermolecular recognition site; other site
546414002733	dimerization interface [polypeptide binding]; other site
546414002734	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06710
546414002735	Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936
546414002736	acyl-activating enzyme (AAE) consensus motif; other site
546414002737	putative AMP binding site [chemical binding]; other site
546414002738	putative active site [active]
546414002739	putative CoA binding site [chemical binding]; other site
546414002740	ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192
546414002741	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
546414002742	substrate binding site [chemical binding]; other site
546414002743	ATP binding site [chemical binding]; other site
546414002744	Protein of unknown function (DUF1999); Region: DUF1999; pfam09390
546414002745	Protein of unknown function (DUF503); Region: DUF503; cl00669
546414002746	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
546414002747	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
546414002748	Catalytic site [active]
546414002749	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
546414002750	Catalytic domain of Protein Kinases; Region: PKc; cd00180
546414002751	active site
546414002752	substrate binding site [chemical binding]; other site
546414002753	ATP binding site [chemical binding]; other site
546414002754	activation loop (A-loop); other site
546414002755	Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase) and related proteins; Region: AmyAc_OligoGlu_like; cd11331
546414002756	alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403
546414002757	active site
546414002758	catalytic site [active]
546414002759	Domain of unknown function (DUF3459); Region: DUF3459; pfam11941
546414002760	Transcriptional regulator [Transcription]; Region: LytR; COG1316
546414002761	LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399
546414002762	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
546414002763	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
546414002764	Coenzyme A binding pocket [chemical binding]; other site
546414002765	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
546414002766	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
546414002767	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
546414002768	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
546414002769	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
546414002770	Lipase (class 2); Region: Lipase_2; pfam01674
546414002771	Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075
546414002772	ATP-dependent Clp protease ATP-binding subunit clpA; Region: ClpA; TIGR02639
546414002773	Clp amino terminal domain; Region: Clp_N; pfam02861
546414002774	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
546414002775	Walker A motif; other site
546414002776	ATP binding site [chemical binding]; other site
546414002777	Walker B motif; other site
546414002778	arginine finger; other site
546414002779	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
546414002780	Walker A motif; other site
546414002781	ATP binding site [chemical binding]; other site
546414002782	Walker B motif; other site
546414002783	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
546414002784	Uncharacterized conserved protein [Function unknown]; Region: COG2127
546414002785	Protein of unknown function (DUF1517); Region: DUF1517; cl01807
546414002786	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083
546414002787	PAP2_like_3 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria and archaea, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_3; cd03393
546414002788	active site
546414002789	ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845
546414002790	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
546414002791	Walker A/P-loop; other site
546414002792	ATP binding site [chemical binding]; other site
546414002793	Q-loop/lid; other site
546414002794	ABC transporter signature motif; other site
546414002795	Walker B; other site
546414002796	D-loop; other site
546414002797	H-loop/switch region; other site
546414002798	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
546414002799	Threonine/homoserine efflux transporter [Amino acid transport and metabolism]; Region: rhtA; COG5006
546414002800	This family is most closely related to the oligosaccharide phosphorylase domain family and other unidentified sequences. Oligosaccharide phosphorylase catalyzes the breakdown of oligosaccharides into glucose-1-phosphate units. They are important...; Region: GT1_Glycogen_Phosphorylase_like; cd04299
546414002801	putative homodimer interface [polypeptide binding]; other site
546414002802	putative active site pocket [active]
546414002803	alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094
546414002804	Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459
546414002805	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
546414002806	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
546414002807	Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009
546414002808	Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079
546414002809	Domain of unknown function (DUF4388); Region: DUF4388; pfam14332
546414002810	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
546414002811	aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012
546414002812	tRNA pseudouridine synthase B; Provisional; Region: PRK14122
546414002813	Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573
546414002814	RNA binding site [nucleotide binding]; other site
546414002815	active site
546414002816	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
546414002817	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
546414002818	RNA binding surface [nucleotide binding]; other site
546414002819	Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870
546414002820	active site
546414002821	Protein of unknown function (DUF423); Region: DUF423; pfam04241
546414002822	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2001
546414002823	MraZ protein; Region: MraZ; pfam02381
546414002824	MraZ protein; Region: MraZ; pfam02381
546414002825	16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050
546414002826	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
546414002827	S-adenosylmethionine binding site [chemical binding]; other site
546414002828	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
546414002829	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
546414002830	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
546414002831	3D domain; Region: 3D; cl01439
546414002832	ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591
546414002833	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
546414002834	Domain of unknown function (DUF4384); Region: DUF4384; pfam14326
546414002835	PEGA domain; Region: PEGA; pfam08308
546414002836	PEGA domain; Region: PEGA; pfam08308
546414002837	Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426
546414002838	putative active site [active]
546414002839	putative CoA binding site [chemical binding]; other site
546414002840	nudix motif; other site
546414002841	metal binding site [ion binding]; metal-binding site
546414002842	nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: PRK12333
546414002843	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528
546414002844	homodimer interface [polypeptide binding]; other site
546414002845	metal binding site [ion binding]; metal-binding site
546414002846	short chain dehydrogenase; Provisional; Region: PRK07326
546414002847	classical (c) SDR, subgroup 4; Region: SDR_c4; cd08929
546414002848	putative NAD(P) binding site [chemical binding]; other site
546414002849	homodimer interface [polypeptide binding]; other site
546414002850	active site
546414002851	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
546414002852	SmpB-tmRNA interface; other site
546414002853	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
546414002854	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
546414002855	active site
546414002856	Sporulation and spore germination; Region: Germane; pfam10646
546414002857	Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196
546414002858	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
546414002859	Walker A/P-loop; other site
546414002860	ATP binding site [chemical binding]; other site
546414002861	Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196
546414002862	SMC proteins Flexible Hinge Domain; Region: SMC_hinge; pfam06470
546414002863	Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196
546414002864	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
546414002865	ABC transporter signature motif; other site
546414002866	Walker B; other site
546414002867	D-loop; other site
546414002868	H-loop/switch region; other site
546414002869	2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563
546414002870	Alpha amylase catalytic domain found in bacterial cyclomaltodextrinases and related proteins; Region: AmyAc_bac_CMD_like_2; cd11339
546414002871	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
546414002872	active site
546414002873	catalytic site [active]
546414002874	Phosphoenolpyruvate carboxylase; Region: PEPcase; cl17418
546414002875	Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352
546414002876	Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382
546414002877	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
546414002878	putative active site [active]
546414002879	metal binding site [ion binding]; metal-binding site
546414002880	homodimer binding site [polypeptide binding]; other site
546414002881	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
546414002882	Ligand Binding Site [chemical binding]; other site
546414002883	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
546414002884	Peptidase family U32; Region: Peptidase_U32; pfam01136
546414002885	Collagenase; Region: DUF3656; pfam12392
546414002886	Quinolinate phosphoribosyl transferase, C-terminal domain; Region: QRPTase_C; pfam01729
546414002887	Peptidase family U32; Region: Peptidase_U32; cl03113
546414002888	Protein of unknown function (DUF402); Region: DUF402; cl00979
546414002889	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
546414002890	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
546414002891	Walker A/P-loop; other site
546414002892	ATP binding site [chemical binding]; other site
546414002893	Q-loop/lid; other site
546414002894	ABC transporter signature motif; other site
546414002895	Walker B; other site
546414002896	D-loop; other site
546414002897	H-loop/switch region; other site
546414002898	YciI-like protein; Reviewed; Region: PRK12866
546414002899	Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748
546414002900	NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226
546414002901	NAD(P) binding pocket [chemical binding]; other site
546414002902	Protein of unknown function (DUF1572); Region: DUF1572; pfam07609
546414002903	DinB superfamily; Region: DinB_2; pfam12867
546414002904	EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556
546414002905	3-phosphoshikimate 1-carboxyvinyltransferase; Region: aroA; TIGR01356
546414002906	hinge; other site
546414002907	active site
546414002908	yiaA/B two helix domain; Region: YiaAB; cl01759
546414002909	Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995
546414002910	dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606
546414002911	SNF2 family N-terminal domain; Region: SNF2_N; pfam00176
546414002912	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
546414002913	ATP binding site [chemical binding]; other site
546414002914	putative Mg++ binding site [ion binding]; other site
546414002915	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
546414002916	nucleotide binding region [chemical binding]; other site
546414002917	ATP-binding site [chemical binding]; other site
546414002918	anthranilate synthase component I, non-proteobacterial lineages; Region: trpE_most; TIGR00564
546414002919	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
546414002920	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
546414002921	para-aminobenzoate synthase component II; Provisional; Region: PRK08857
546414002922	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
546414002923	glutamine binding [chemical binding]; other site
546414002924	catalytic triad [active]
546414002925	anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188
546414002926	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
546414002927	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
546414002928	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
546414002929	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
546414002930	putative DNA binding site [nucleotide binding]; other site
546414002931	putative Zn2+ binding site [ion binding]; other site
546414002932	AsnC family; Region: AsnC_trans_reg; pfam01037
546414002933	Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509
546414002934	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
546414002935	FeS/SAM binding site; other site
546414002936	Lysine-2,3-aminomutase; Region: LAM_C; pfam12544
546414002937	4-aminobutyrate aminotransferase; Provisional; Region: PRK05769
546414002938	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
546414002939	inhibitor-cofactor binding pocket; inhibition site
546414002940	pyridoxal 5'-phosphate binding site [chemical binding]; other site
546414002941	catalytic residue [active]
546414002942	YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486
546414002943	generic binding surface I; other site
546414002944	generic binding surface II; other site
546414002945	Mycoplasma pulmonis MnuA nuclease-like; Region: MnuA_DNase1-like; cd10283
546414002946	putative active site [active]
546414002947	putative catalytic site [active]
546414002948	putative Mg binding site IVb [ion binding]; other site
546414002949	putative phosphate binding site [ion binding]; other site
546414002950	putative DNA binding site [nucleotide binding]; other site
546414002951	putative Mg binding site IVa [ion binding]; other site
546414002952	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
546414002953	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
546414002954	catalytic triad [active]
546414002955	tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037
546414002956	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
546414002957	TilS substrate C-terminal domain; Region: TilS_C; smart00977
546414002958	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
546414002959	nucleoside/Zn binding site; other site
546414002960	dimer interface [polypeptide binding]; other site
546414002961	catalytic motif [active]
546414002962	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
546414002963	synthetase active site [active]
546414002964	NTP binding site [chemical binding]; other site
546414002965	metal binding site [ion binding]; metal-binding site
546414002966	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
546414002967	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
546414002968	active site
546414002969	metal binding site [ion binding]; metal-binding site
546414002970	short chain dehydrogenase; Provisional; Region: PRK08219
546414002971	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
546414002972	NAD(P) binding site [chemical binding]; other site
546414002973	active site
546414002974	Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492
546414002975	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915
546414002976	Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419
546414002977	motif I; other site
546414002978	active site
546414002979	ATP-dependent helicase HrpB; Region: DEAH_box_HrpB; TIGR01970
546414002980	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
546414002981	ATP binding site [chemical binding]; other site
546414002982	putative Mg++ binding site [ion binding]; other site
546414002983	nucleotide binding region [chemical binding]; other site
546414002984	helicase superfamily c-terminal domain; Region: HELICc; smart00490
546414002985	ATP-binding site [chemical binding]; other site
546414002986	Helicase associated domain (HA2) Add an annotation; Region: HA2; smart00847
546414002987	ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482
546414002988	Trans-aconitate methyltransferase [General function prediction only]; Region: Tam; COG4106
546414002989	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
546414002990	S-adenosylmethionine binding site [chemical binding]; other site
546414002991	Rad52/22 family double-strand break repair protein; Region: Rad52_Rad22; cl01936
546414002992	Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cd00190
546414002993	cleavage site
546414002994	active site
546414002995	substrate binding sites [chemical binding]; other site
546414002996	Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922
546414002997	Peptidase S8 family domain in ProteinaseK-like proteins; Region: Peptidases_S8_PCSK9_ProteinaseK_like; cd04077
546414002998	calcium binding site 2 [ion binding]; other site
546414002999	Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404
546414003000	active site
546414003001	catalytic triad [active]
546414003002	calcium binding site 1 [ion binding]; other site
546414003003	Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914
546414003004	putative active site pocket [active]
546414003005	4-fold oligomerization interface [polypeptide binding]; other site
546414003006	metal binding residues [ion binding]; metal-binding site
546414003007	3-fold/trimer interface [polypeptide binding]; other site
546414003008	imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13181
546414003009	Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748
546414003010	putative active site [active]
546414003011	oxyanion strand; other site
546414003012	catalytic triad [active]
546414003013	branched-chain amino acid aminotransferase; Provisional; Region: PRK13357
546414003014	BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids  leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557
546414003015	homodimer interface [polypeptide binding]; other site
546414003016	substrate-cofactor binding pocket; other site
546414003017	catalytic residue [active]
546414003018	glycogen branching enzyme; Provisional; Region: PRK14706
546414003019	N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855
546414003020	Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322
546414003021	active site
546414003022	catalytic site [active]
546414003023	Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806
546414003024	This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146
546414003025	dimer interface [polypeptide binding]; other site
546414003026	FMN binding site [chemical binding]; other site
546414003027	NADPH bind site [chemical binding]; other site
546414003028	Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473
546414003029	tartrate dehydrogenase; Region: TTC; TIGR02089
546414003030	FAD dependent oxidoreductase; Region: DAO; pfam01266
546414003031	Uncharacterized conserved protein [Function unknown]; Region: COG4121
546414003032	Domain of unknown function (DUF1990); Region: DUF1990; pfam09348
546414003033	Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008
546414003034	Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I).  TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502
546414003035	tetramer interface [polypeptide binding]; other site
546414003036	pyridoxal 5'-phosphate binding site [chemical binding]; other site
546414003037	catalytic residue [active]
546414003038	CAAX protease self-immunity; Region: Abi; pfam02517
546414003039	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2839
546414003040	isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437
546414003041	Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811
546414003042	homotetramer interface [polypeptide binding]; other site
546414003043	FMN binding site [chemical binding]; other site
546414003044	homodimer contacts [polypeptide binding]; other site
546414003045	putative active site [active]
546414003046	putative substrate binding site [chemical binding]; other site
546414003047	Bacterial low temperature requirement A protein (LtrA); Region: LtrA; cl01754
546414003048	Holliday junction DNA helicase RuvA; Provisional; Region: ruvA; PRK14603
546414003049	RuvA N terminal domain; Region: RuvA_N; pfam01330
546414003050	RuvA, C-terminal domain; Region: RuvA_C; pfam07499
546414003051	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
546414003052	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
546414003053	methionyl-tRNA synthetase; Reviewed; Region: PRK12267
546414003054	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
546414003055	active site
546414003056	HIGH motif; other site
546414003057	KMSKS motif; other site
546414003058	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
546414003059	tRNA binding surface [nucleotide binding]; other site
546414003060	anticodon binding site; other site
546414003061	tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins.  This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties.  MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800
546414003062	dimer interface [polypeptide binding]; other site
546414003063	putative tRNA-binding site [nucleotide binding]; other site
546414003064	glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416
546414003065	conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826
546414003066	family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187
546414003067	phosphate binding site [ion binding]; other site
546414003068	putative substrate binding pocket [chemical binding]; other site
546414003069	dimer interface [polypeptide binding]; other site
546414003070	Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079
546414003071	gamma-glutamyl phosphate reductase; Region: proA; TIGR00407
546414003072	putative catalytic cysteine [active]
546414003073	putative RNA polymerase sigma E protein; Provisional; Region: PRK13919
546414003074	1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444
546414003075	Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007
546414003076	TPP-binding site; other site
546414003077	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
546414003078	PYR/PP interface [polypeptide binding]; other site
546414003079	dimer interface [polypeptide binding]; other site
546414003080	TPP binding site [chemical binding]; other site
546414003081	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
546414003082	PspA/IM30 family; Region: PspA_IM30; pfam04012
546414003083	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
546414003084	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
546414003085	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
546414003086	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
546414003087	dimer interface [polypeptide binding]; other site
546414003088	conserved gate region; other site
546414003089	putative PBP binding loops; other site
546414003090	ABC-ATPase subunit interface; other site
546414003091	ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism]; Region: UgpA; COG1175
546414003092	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
546414003093	dimer interface [polypeptide binding]; other site
546414003094	conserved gate region; other site
546414003095	putative PBP binding loops; other site
546414003096	ABC-ATPase subunit interface; other site
546414003097	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
546414003098	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
546414003099	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
546414003100	Major Facilitator Superfamily; Region: MFS_1; pfam07690
546414003101	putative substrate translocation pore; other site
546414003102	RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223
546414003103	tRNA and rRNA cytosine-C5-methylases [Translation, ribosomal structure and biogenesis]; Region: Sun; COG0144
546414003104	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
546414003105	S-adenosylmethionine binding site [chemical binding]; other site
546414003106	purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819
546414003107	Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820
546414003108	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
546414003109	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
546414003110	Nitronate monooxygenase; Region: NMO; pfam03060
546414003111	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
546414003112	FMN binding site [chemical binding]; other site
546414003113	substrate binding site [chemical binding]; other site
546414003114	putative catalytic residue [active]
546414003115	Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123
546414003116	Histone deacetylase class IV also known as histone deacetylase 11; Region: HDAC_classIV; cd09993
546414003117	putative active site [active]
546414003118	Zn binding site [ion binding]; other site
546414003119	Peptide chain release factor RF-3 [Translation, ribosomal structure and biogenesis]; Region: PrfC; COG4108
546414003120	Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169
546414003121	G1 box; other site
546414003122	putative GEF interaction site [polypeptide binding]; other site
546414003123	GTP/Mg2+ binding site [chemical binding]; other site
546414003124	Switch I region; other site
546414003125	G2 box; other site
546414003126	G3 box; other site
546414003127	Switch II region; other site
546414003128	G4 box; other site
546414003129	G5 box; other site
546414003130	RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689
546414003131	putative active site [active]
546414003132	Peptidase_C39 like family; Region: Peptidase_C39_2; pfam13529
546414003133	Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309
546414003134	Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073
546414003135	formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027
546414003136	N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875
546414003137	Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648
546414003138	putative active site [active]
546414003139	putative substrate binding site [chemical binding]; other site
546414003140	putative cosubstrate binding site; other site
546414003141	catalytic site [active]
546414003142	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
546414003143	Quinone oxidoreductase (QOR); Region: QOR1; cd08241
546414003144	NAD(P) binding site [chemical binding]; other site
546414003145	multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154
546414003146	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
546414003147	substrate binding site [chemical binding]; other site
546414003148	oxyanion hole (OAH) forming residues; other site
546414003149	trimer interface [polypeptide binding]; other site
546414003150	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
546414003151	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
546414003152	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
546414003153	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
546414003154	Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439
546414003155	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
546414003156	acetyl-CoA acetyltransferase; Provisional; Region: PRK07108
546414003157	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
546414003158	dimer interface [polypeptide binding]; other site
546414003159	active site
546414003160	(dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14334
546414003161	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
546414003162	Amidase; Region: Amidase; cl11426
546414003163	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
546414003164	Late embryogenesis abundant protein; Region: LEA_2; cl12118
546414003165	Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834
546414003166	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
546414003167	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
546414003168	NlpC/P60 family; Region: NLPC_P60; pfam00877
546414003169	Domain of unknown function (DUF1844); Region: DUF1844; pfam08899
546414003170	D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563
546414003171	putative active site [active]
546414003172	dimerization interface [polypeptide binding]; other site
546414003173	putative tRNAtyr binding site [nucleotide binding]; other site
546414003174	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
546414003175	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
546414003176	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
546414003177	Peptidase family M23; Region: Peptidase_M23; pfam01551
546414003178	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
546414003179	CoenzymeA binding site [chemical binding]; other site
546414003180	subunit interaction site [polypeptide binding]; other site
546414003181	PHB binding site; other site
546414003182	leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301
546414003183	D-3-phosphoglycerate dehydrogenase; Region: PGDH; TIGR01327
546414003184	Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173
546414003185	ligand binding site [chemical binding]; other site
546414003186	NAD binding site [chemical binding]; other site
546414003187	dimerization interface [polypeptide binding]; other site
546414003188	catalytic site [active]
546414003189	C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902
546414003190	putative L-serine binding site [chemical binding]; other site
546414003191	NLI interacting factor-like phosphatase; Region: NIF; pfam03031
546414003192	Protein of unknown function (DUF3995); Region: DUF3995; pfam13160
546414003193	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
546414003194	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
546414003195	The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464
546414003196	CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385
546414003197	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
546414003198	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
546414003199	Alanine-glyoxylate aminotransferase (AGAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to alanine-glyoxylate aminotransferase (AGAT); Region: AGAT_like; cd06451
546414003200	homodimer interface [polypeptide binding]; other site
546414003201	pyridoxal 5'-phosphate binding site [chemical binding]; other site
546414003202	catalytic residue [active]
546414003203	FOG: CBS domain [General function prediction only]; Region: COG0517
546414003204	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in  the acetoin utilization proteins in bacteria. Acetoin is a product of fermentative metabolism in many prokaryotic and eukaryotic microorganisms.  They produce...; Region: CBS_pair_ACT_assoc2; cd04585
546414003205	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
546414003206	Outer membrane protein (OmpH-like); Region: OmpH; pfam03938
546414003207	Outer membrane protein (OmpH-like); Region: OmpH; pfam03938
546414003208	Uncharacterized stress protein (general stress protein 26) [General function prediction only]; Region: COG3871
546414003209	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
546414003210	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
546414003211	MFS/sugar transport protein; Region: MFS_2; pfam13347
546414003212	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
546414003213	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
546414003214	active site
546414003215	Predicted flavoprotein [General function prediction only]; Region: COG0431
546414003216	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
546414003217	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
546414003218	DNA-binding site [nucleotide binding]; DNA binding site
546414003219	RNA-binding motif; other site
546414003220	Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663
546414003221	Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645
546414003222	trimer interface [polypeptide binding]; other site
546414003223	putative metal binding site [ion binding]; other site
546414003224	ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917
546414003225	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
546414003226	generic binding surface II; other site
546414003227	ssDNA binding site; other site
546414003228	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
546414003229	ATP binding site [chemical binding]; other site
546414003230	putative Mg++ binding site [ion binding]; other site
546414003231	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
546414003232	nucleotide binding region [chemical binding]; other site
546414003233	ATP-binding site [chemical binding]; other site
546414003234	Protein of unknown function (DUF2572); Region: DUF2572; pfam10833
546414003235	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2354
546414003236	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
546414003237	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
546414003238	putative substrate translocation pore; other site
546414003239	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
546414003240	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
546414003241	active site
546414003242	catalytic tetrad [active]
546414003243	FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2  has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451
546414003244	putative active site [active]
546414003245	putative catalytic site [active]
546414003246	Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301
546414003247	aspartyl-tRNA synthetase; Provisional; Region: aspC; PRK05159
546414003248	Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930
546414003249	Dimer interface [polypeptide binding]; other site
546414003250	anticodon binding site; other site
546414003251	Asx tRNA synthetase (AspRS/AsnRS) class II core domain.  Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776
546414003252	homodimer interface [polypeptide binding]; other site
546414003253	motif 1; other site
546414003254	motif 2; other site
546414003255	active site
546414003256	motif 3; other site
546414003257	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
546414003258	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
546414003259	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
546414003260	Chromate transporter; Region: Chromate_transp; pfam02417
546414003261	Chromate transporter; Region: Chromate_transp; pfam02417
546414003262	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4586
546414003263	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
546414003264	Walker A/P-loop; other site
546414003265	ATP binding site [chemical binding]; other site
546414003266	Q-loop/lid; other site
546414003267	ABC transporter signature motif; other site
546414003268	Walker B; other site
546414003269	D-loop; other site
546414003270	H-loop/switch region; other site
546414003271	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587
546414003272	ABC-2 type transporter; Region: ABC2_membrane; cl17235
546414003273	ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496
546414003274	Carboxymuconolactone decarboxylase family; Region: CMD; cl00460
546414003275	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
546414003276	Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis.  Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932
546414003277	active site
546414003278	FMN binding site [chemical binding]; other site
546414003279	substrate binding site [chemical binding]; other site
546414003280	homotetramer interface [polypeptide binding]; other site
546414003281	catalytic residue [active]
546414003282	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
546414003283	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
546414003284	Walker A/P-loop; other site
546414003285	ATP binding site [chemical binding]; other site
546414003286	Q-loop/lid; other site
546414003287	ABC transporter signature motif; other site
546414003288	Walker B; other site
546414003289	D-loop; other site
546414003290	H-loop/switch region; other site
546414003291	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
546414003292	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
546414003293	ligand binding site [chemical binding]; other site
546414003294	flexible hinge region; other site
546414003295	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
546414003296	non-specific DNA interactions [nucleotide binding]; other site
546414003297	DNA binding site [nucleotide binding]
546414003298	sequence specific DNA binding site [nucleotide binding]; other site
546414003299	putative cAMP binding site [chemical binding]; other site
546414003300	Domain of unknown function (DUF2437); Region: DUF2437; pfam10370
546414003301	4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase, C-terminal subunit; Region: HpaG-C-term; TIGR02303
546414003302	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
546414003303	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
546414003304	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
546414003305	active site
546414003306	DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144
546414003307	DNA polymerase III, delta subunit; Region: holA; TIGR01128
546414003308	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
546414003309	Catalytic domain of Protein Kinases; Region: PKc; cd00180
546414003310	active site
546414003311	ATP binding site [chemical binding]; other site
546414003312	substrate binding site [chemical binding]; other site
546414003313	activation loop (A-loop); other site
546414003314	Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152
546414003315	heterotetramer interface [polypeptide binding]; other site
546414003316	active site pocket [active]
546414003317	cleavage site
546414003318	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
546414003319	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
546414003320	dimer interface [polypeptide binding]; other site
546414003321	conserved gate region; other site
546414003322	putative PBP binding loops; other site
546414003323	ABC-ATPase subunit interface; other site
546414003324	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
546414003325	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
546414003326	dimer interface [polypeptide binding]; other site
546414003327	conserved gate region; other site
546414003328	putative PBP binding loops; other site
546414003329	ABC-ATPase subunit interface; other site
546414003330	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
546414003331	The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493
546414003332	peptide binding site [polypeptide binding]; other site
546414003333	Beta-N-acetylhexosaminidases of glycosyl hydrolase family 20 (GH20) catalyze the removal of beta-1,4-linked N-acetyl-D-hexosamine residues from the non-reducing ends of N-acetyl-beta-D-hexosaminides including N-acetylglucosides and N-acetylgalactosides; Region: GH20_hexosaminidase; cl02948
546414003334	active site
546414003335	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
546414003336	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
546414003337	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
546414003338	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971
546414003339	EDD domain protein, DegV family; Region: DegV; TIGR00762
546414003340	Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645
546414003341	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
546414003342	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
546414003343	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
546414003344	The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  Many of these band 7 domain-containing proteins are lipid raft-associated.  Individual proteins of this...; Region: Band_7; cl02525
546414003345	hypothetical protein; Provisional; Region: PRK04233
546414003346	SEC-C motif; Region: SEC-C; pfam02810
546414003347	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
546414003348	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; cl06870
546414003349	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
546414003350	Response regulator receiver domain; Region: Response_reg; pfam00072
546414003351	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
546414003352	active site
546414003353	phosphorylation site [posttranslational modification]
546414003354	intermolecular recognition site; other site
546414003355	dimerization interface [polypeptide binding]; other site
546414003356	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
546414003357	Coenzyme A binding pocket [chemical binding]; other site
546414003358	Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753
546414003359	N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436
546414003360	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
546414003361	bifunctional preprotein translocase subunit SecD/SecF; Reviewed; Region: PRK13024
546414003362	protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916
546414003363	Protein export membrane protein; Region: SecD_SecF; pfam02355
546414003364	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
546414003365	Translation initiation factor 2 (IF-2; GTPase) [Translation, ribosomal structure and biogenesis]; Region: InfB; COG0532
546414003366	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
546414003367	G1 box; other site
546414003368	putative GEF interaction site [polypeptide binding]; other site
546414003369	GTP/Mg2+ binding site [chemical binding]; other site
546414003370	Switch I region; other site
546414003371	G2 box; other site
546414003372	G3 box; other site
546414003373	Switch II region; other site
546414003374	G4 box; other site
546414003375	G5 box; other site
546414003376	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
546414003377	Translation-initiation factor 2; Region: IF-2; pfam11987
546414003378	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
546414003379	Predicted nucleic-acid-binding protein implicated in transcription termination [Transcription]; Region: COG2740
546414003380	putative RNA binding cleft [nucleotide binding]; other site
546414003381	transcription termination factor NusA; Region: NusA; TIGR01953
546414003382	NusA N-terminal domain; Region: NusA_N; pfam08529
546414003383	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
546414003384	RNA binding site [nucleotide binding]; other site
546414003385	homodimer interface [polypeptide binding]; other site
546414003386	NusA-like KH domain; Region: KH_5; pfam13184
546414003387	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
546414003388	G-X-X-G motif; other site
546414003389	hypothetical protein; Provisional; Region: PRK14645
546414003390	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG0779
546414003391	heptamer interface [polypeptide binding]; other site
546414003392	Sm1 motif; other site
546414003393	hexamer interface [polypeptide binding]; other site
546414003394	RNA binding site [nucleotide binding]; other site
546414003395	Sm2 motif; other site
546414003396	Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775
546414003397	Predicted RNA binding protein (contains ribosomal protein S1 domain) [Translation, ribosomal structure and biogenesis]; Region: VacB; COG1098
546414003398	S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692
546414003399	RNA binding site [nucleotide binding]; other site
546414003400	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
546414003401	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
546414003402	protein binding site [polypeptide binding]; other site
546414003403	AAK_NAGK-UC: N-Acetyl-L-glutamate kinase - uncharacterized (NAGK-UC). This domain is similar to Escherichia coli and Pseudomonas aeruginosa NAGKs which catalyze the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the...; Region: AAK_NAGK-UC; cd04251
546414003404	putative nucleotide binding site [chemical binding]; other site
546414003405	putative N-acetyl-L-glutamate binding site [chemical binding]; other site
546414003406	Protein of unknown function (DUF1294); Region: DUF1294; pfam06961
546414003407	4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761
546414003408	4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045
546414003409	Predicted membrane protein [Function unknown]; Region: COG0344
546414003410	Predicted dehydrogenase [General function prediction only]; Region: COG5322
546414003411	NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226
546414003412	NAD(P) binding pocket [chemical binding]; other site
546414003413	Domain of unknown function (DUF4388); Region: DUF4388; pfam14332
546414003414	Uncharacterized conserved protein [Function unknown]; Region: COG0062
546414003415	B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171
546414003416	putative substrate binding site [chemical binding]; other site
546414003417	putative ATP binding site [chemical binding]; other site
546414003418	TPR repeat; Region: TPR_11; pfam13414
546414003419	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
546414003420	binding surface
546414003421	TPR motif; other site
546414003422	TPR repeat; Region: TPR_11; pfam13414
546414003423	16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274
546414003424	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
546414003425	S-adenosylmethionine binding site [chemical binding]; other site
546414003426	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
546414003427	ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192
546414003428	substrate binding site [chemical binding]; other site
546414003429	ATP binding site [chemical binding]; other site
546414003430	Methyltransferase domain; Region: Methyltransf_31; pfam13847
546414003431	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
546414003432	S-adenosylmethionine binding site [chemical binding]; other site
546414003433	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
546414003434	Catalytic NodB homology domain of uncharacterized bacterial polysaccharide deacetylases; Region: CE4_NodB_like_3; cd10959
546414003435	NodB motif; other site
546414003436	putative active site [active]
546414003437	putative catalytic site [active]
546414003438	putative Zn binding site [ion binding]; other site
546414003439	UDP-N-acetylglucosamine:LPS N-acetylglucosamine transferase [Cell envelope biogenesis, outer membrane]; Region: MurG; COG0707
546414003440	Monogalactosyldiacylglycerol (MGDG) synthase; Region: MGDG_synth; pfam06925
546414003441	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
546414003442	Predicted permeases [General function prediction only]; Region: COG0795
546414003443	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
546414003444	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
546414003445	rod shape-determining protein MreB; Provisional; Region: PRK13930
546414003446	MreB and similar proteins; Region: MreB_like; cd10225
546414003447	nucleotide binding site [chemical binding]; other site
546414003448	Mg binding site [ion binding]; other site
546414003449	putative protofilament interaction site [polypeptide binding]; other site
546414003450	RodZ interaction site [polypeptide binding]; other site
546414003451	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
546414003452	Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158
546414003453	FAD binding site [chemical binding]; other site
546414003454	homotetramer interface [polypeptide binding]; other site
546414003455	substrate binding pocket [chemical binding]; other site
546414003456	catalytic base [active]
546414003457	dihydroxy-acid dehydratase; Provisional; Region: PRK00911
546414003458	peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059
546414003459	PPIC-type PPIASE domain; Region: Rotamase_3; pfam13616
546414003460	FemAB family; Region: FemAB; pfam02388
546414003461	Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; cl17497
546414003462	tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026
546414003463	16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK13829
546414003464	RimM N-terminal domain; Region: RimM; pfam01782
546414003465	PRC-barrel domain; Region: PRC; pfam05239
546414003466	Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837
546414003467	jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation.  The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414
546414003468	G-X-X-G motif; other site
546414003469	30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040
546414003470	Peptidase family M23; Region: Peptidase_M23; pfam01551
546414003471	Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177
546414003472	cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026
546414003473	Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884
546414003474	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
546414003475	Walker A/P-loop; other site
546414003476	ATP binding site [chemical binding]; other site
546414003477	Q-loop/lid; other site
546414003478	ABC transporter signature motif; other site
546414003479	Walker B; other site
546414003480	D-loop; other site
546414003481	H-loop/switch region; other site
546414003482	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
546414003483	C-terminal peptidase (prc); Region: prc; TIGR00225
546414003484	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
546414003485	protein binding site [polypeptide binding]; other site
546414003486	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
546414003487	Catalytic dyad [active]
546414003488	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
546414003489	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
546414003490	Winged helix-turn helix; Region: HTH_29; pfam13551
546414003491	Homeodomain-like domain; Region: HTH_23; cl17451
546414003492	Homeodomain-like domain; Region: HTH_32; pfam13565
546414003493	DDE superfamily endonuclease; Region: DDE_3; pfam13358
546414003494	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
546414003495	Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818
546414003496	Predicted metal-dependent hydrolase [General function prediction only]; Region: COG0319
546414003497	Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702
546414003498	PhoH-like protein; Region: PhoH; pfam02562
546414003499	shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258
546414003500	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
546414003501	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
546414003502	NAD(P) binding site [chemical binding]; other site
546414003503	shikimate binding site; other site
546414003504	CHASE domain; Region: CHASE; cl01369
546414003505	PAS domain S-box; Region: sensory_box; TIGR00229
546414003506	PAS domain; Region: PAS; smart00091
546414003507	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
546414003508	Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086
546414003509	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
546414003510	putative active site [active]
546414003511	heme pocket [chemical binding]; other site
546414003512	GAF domain; Region: GAF_3; pfam13492
546414003513	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
546414003514	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
546414003515	dimer interface [polypeptide binding]; other site
546414003516	phosphorylation site [posttranslational modification]
546414003517	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
546414003518	ATP binding site [chemical binding]; other site
546414003519	Mg2+ binding site [ion binding]; other site
546414003520	G-X-G motif; other site
546414003521	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
546414003522	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
546414003523	active site
546414003524	phosphorylation site [posttranslational modification]
546414003525	intermolecular recognition site; other site
546414003526	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
546414003527	dimerization interface [polypeptide binding]; other site
546414003528	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
546414003529	dimer interface [polypeptide binding]; other site
546414003530	phosphorylation site [posttranslational modification]
546414003531	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
546414003532	ATP binding site [chemical binding]; other site
546414003533	Mg2+ binding site [ion binding]; other site
546414003534	G-X-G motif; other site
546414003535	Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765
546414003536	Predicted flavoprotein [General function prediction only]; Region: COG0431
546414003537	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
546414003538	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
546414003539	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
546414003540	Winged helix DNA-binding domain; Region: HTH_27; pfam13463
546414003541	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
546414003542	Coenzyme A binding pocket [chemical binding]; other site
546414003543	probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858
546414003544	putative luciferase-like monooxygenase, FMN-dependent, CE1758 family; Region: LLM_CE1758_fam; TIGR04036
546414003545	dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606
546414003546	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
546414003547	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
546414003548	YhfW family, C-terminal Rieske domain; YhfW is a protein of unknown function with an N-terminal DadA-like (glycine/D-amino acid dehydrogenase) domain and a C-terminal Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain involved in...; Region: Rieske_YhfW_C; cd03477
546414003549	[2Fe-2S] cluster binding site [ion binding]; other site
546414003550	penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423
546414003551	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
546414003552	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
546414003553	rod shape-determining protein MreC; Provisional; Region: PRK13922
546414003554	Septum formation initiator; Region: DivIC; cl17659
546414003555	rod shape-determining protein MreC; Region: MreC; pfam04085
546414003556	Maf-like protein; Provisional; Region: PRK14361
546414003557	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
546414003558	active site
546414003559	dimer interface [polypeptide binding]; other site
546414003560	2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959
546414003561	intersubunit interface [polypeptide binding]; other site
546414003562	active site
546414003563	catalytic residue [active]
546414003564	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
546414003565	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
546414003566	catalytic triad [active]
546414003567	RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398
546414003568	tetramer (dimer of dimers) interface [polypeptide binding]; other site
546414003569	active site
546414003570	dimer interface [polypeptide binding]; other site
546414003571	Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331
546414003572	TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955
546414003573	catalytic residues [active]
546414003574	Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018
546414003575	Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; pfam03485
546414003576	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
546414003577	active site
546414003578	HIGH motif; other site
546414003579	KMSK motif region; other site
546414003580	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
546414003581	tRNA binding surface [nucleotide binding]; other site
546414003582	anticodon binding site; other site
546414003583	Acyltransferase family; Region: Acyl_transf_3; pfam01757
546414003584	prephenate dehydrogenase; Validated; Region: PRK06545
546414003585	prephenate dehydrogenase; Validated; Region: PRK08507
546414003586	C-terminal ACT domain of the monofunctional, NAD dependent, prephenate dehydrogenase (PDH); Region: ACT_PDH-BS; cd04909
546414003587	hypothetical protein; Provisional; Region: PRK10621
546414003588	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
546414003589	methionine sulfoxide reductase A; Provisional; Region: PRK14054
546414003590	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258
546414003591	MOSC domain; Region: MOSC; pfam03473
546414003592	Catalytic domain, repeat 1, of phospholipase D from Streptomyces Sp. Strain PMF and similar proteins; Region: PLDc_PMFPLD_like_1; cd09108
546414003593	domain interface [polypeptide binding]; other site
546414003594	Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502
546414003595	putative active site [active]
546414003596	catalytic site [active]
546414003597	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
546414003598	putative active site [active]
546414003599	catalytic site [active]
546414003600	RNHCP domain; Region: RNHCP; pfam12647
546414003601	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
546414003602	phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885
546414003603	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
546414003604	Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071
546414003605	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
546414003606	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_4; cd08500
546414003607	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
546414003608	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
546414003609	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
546414003610	dimer interface [polypeptide binding]; other site
546414003611	conserved gate region; other site
546414003612	putative PBP binding loops; other site
546414003613	ABC-ATPase subunit interface; other site
546414003614	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
546414003615	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4239
546414003616	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
546414003617	dimer interface [polypeptide binding]; other site
546414003618	conserved gate region; other site
546414003619	putative PBP binding loops; other site
546414003620	ABC-ATPase subunit interface; other site
546414003621	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
546414003622	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
546414003623	Walker A/P-loop; other site
546414003624	ATP binding site [chemical binding]; other site
546414003625	Q-loop/lid; other site
546414003626	ABC transporter signature motif; other site
546414003627	Walker B; other site
546414003628	D-loop; other site
546414003629	H-loop/switch region; other site
546414003630	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
546414003631	oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079
546414003632	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
546414003633	Walker A/P-loop; other site
546414003634	ATP binding site [chemical binding]; other site
546414003635	Q-loop/lid; other site
546414003636	ABC transporter signature motif; other site
546414003637	Walker B; other site
546414003638	D-loop; other site
546414003639	H-loop/switch region; other site
546414003640	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
546414003641	Uncharacterized conserved protein [Function unknown]; Region: COG5316
546414003642	Domain of unknown function (DUF4139); Region: DUF4139; pfam13598
546414003643	5,10-methylenetetrahydrofolate reductase [Amino acid transport and metabolism]; Region: MetF; COG0685
546414003644	FAD binding site [chemical binding]; other site
546414003645	Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646
546414003646	B12-dependent methionine synthase; Provisional; Region: metH; PRK09490
546414003647	MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH).  Cobalamin-dependent...; Region: MeTr; cd00740
546414003648	substrate binding pocket [chemical binding]; other site
546414003649	B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069
546414003650	B12 binding site [chemical binding]; other site
546414003651	cobalt ligand [ion binding]; other site
546414003652	Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965
546414003653	Domain of unknown function (DUF4383); Region: DUF4383; pfam14325
546414003654	Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077
546414003655	Prephenate dehydratase; Region: PDT; pfam00800
546414003656	C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905
546414003657	putative L-Phe binding site [chemical binding]; other site
546414003658	amidase; Provisional; Region: PRK06828
546414003659	Amidase; Region: Amidase; pfam01425
546414003660	site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236
546414003661	phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189
546414003662	Int/Topo IB signature motif; other site
546414003663	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
546414003664	GAF domain; Region: GAF; pfam01590
546414003665	PAS domain; Region: PAS_9; pfam13426
546414003666	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
546414003667	putative active site [active]
546414003668	heme pocket [chemical binding]; other site
546414003669	PAS domain S-box; Region: sensory_box; TIGR00229
546414003670	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
546414003671	putative active site [active]
546414003672	heme pocket [chemical binding]; other site
546414003673	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
546414003674	GAF domain; Region: GAF_2; pfam13185
546414003675	PAS domain S-box; Region: sensory_box; TIGR00229
546414003676	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
546414003677	putative active site [active]
546414003678	heme pocket [chemical binding]; other site
546414003679	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
546414003680	GAF domain; Region: GAF; pfam01590
546414003681	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
546414003682	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
546414003683	Zn2+ binding site [ion binding]; other site
546414003684	Mg2+ binding site [ion binding]; other site
546414003685	Protein of unknown function (DUF3592); Region: DUF3592; pfam12158
546414003686	Stage V sporulation protein S (SpoVS); Region: SpoVS; pfam04232
546414003687	Predicted Zn-dependent protease [General function prediction only]; Region: COG2738
546414003688	Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151
546414003689	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
546414003690	active site residue [active]
546414003691	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
546414003692	active site residue [active]
546414003693	Ornithine/acetylornithine aminotransferase [Amino acid transport and metabolism]; Region: ArgD; COG4992
546414003694	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
546414003695	inhibitor-cofactor binding pocket; inhibition site
546414003696	pyridoxal 5'-phosphate binding site [chemical binding]; other site
546414003697	catalytic residue [active]
546414003698	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
546414003699	cation diffusion facilitator family transporter; Region: CDF; TIGR01297
546414003700	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
546414003701	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
546414003702	putative dimer interface [polypeptide binding]; other site
546414003703	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
546414003704	IPP transferase; Region: IPPT; pfam01715
546414003705	glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00844
546414003706	ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508
546414003707	ligand binding site; other site
546414003708	oligomer interface; other site
546414003709	Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651
546414003710	dimer interface [polypeptide binding]; other site
546414003711	N-terminal domain interface [polypeptide binding]; other site
546414003712	sulfate 1 binding site; other site
546414003713	ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389
546414003714	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
546414003715	ATP binding site [chemical binding]; other site
546414003716	putative Mg++ binding site [ion binding]; other site
546414003717	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
546414003718	nucleotide binding region [chemical binding]; other site
546414003719	ATP-binding site [chemical binding]; other site
546414003720	This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956
546414003721	HRDC domain; Region: HRDC; pfam00570
546414003722	HRDC domain; Region: HRDC; pfam00570
546414003723	Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247
546414003724	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
546414003725	Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217
546414003726	Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891
546414003727	G1 box; other site
546414003728	putative GEF interaction site [polypeptide binding]; other site
546414003729	GTP/Mg2+ binding site [chemical binding]; other site
546414003730	Switch I region; other site
546414003731	G2 box; other site
546414003732	G3 box; other site
546414003733	Switch II region; other site
546414003734	G4 box; other site
546414003735	G5 box; other site
546414003736	BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu.  BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691
546414003737	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a highly...; Region: BipA_TypA_C; cd03710
546414003738	Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, isobutyryl-CoA mutase (ICM)-like subfamily; contains archaeal and bacterial proteins similar to the large subunit of Streptomyces cinnamonensis coenzyme B12-dependent ICM. ICM...; Region: MM_CoA_mutase_ICM_like; cd03680
546414003739	Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099
546414003740	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915
546414003741	active site
546414003742	motif I; other site
546414003743	motif II; other site
546414003744	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
546414003745	Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384
546414003746	asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932
546414003747	AsnRS_cyto_like_N: N-terminal, anticodon recognition domain of the type found in human and Saccharomyces cerevisiae cytoplasmic asparaginyl-tRNA synthetase (AsnRS), in Brugia malayai AsnRs and, in various putative bacterial AsnRSs.  This domain is a...; Region: AsnRS_cyto_like_N; cd04323
546414003748	putative dimer interface [polypeptide binding]; other site
546414003749	putative anticodon binding site; other site
546414003750	Asx tRNA synthetase (AspRS/AsnRS) class II core domain.  Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776
546414003751	homodimer interface [polypeptide binding]; other site
546414003752	motif 1; other site
546414003753	motif 2; other site
546414003754	active site
546414003755	motif 3; other site
546414003756	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
546414003757	triosephosphate isomerase; Provisional; Region: PRK14565
546414003758	substrate binding site [chemical binding]; other site
546414003759	dimer interface [polypeptide binding]; other site
546414003760	catalytic triad [active]
546414003761	NIPSNAP; Region: NIPSNAP; pfam07978
546414003762	Phosphoglycerate kinase; Region: PGK; pfam00162
546414003763	Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318
546414003764	substrate binding site [chemical binding]; other site
546414003765	hinge regions; other site
546414003766	ADP binding site [chemical binding]; other site
546414003767	catalytic site [active]
546414003768	Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057
546414003769	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044
546414003770	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
546414003771	aspartate kinase; Provisional; Region: PRK06291
546414003772	AAK_AK-LysC-like: Amino Acid Kinase Superfamily (AAK), AK-LysC-like; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive AK isoenzyme found in higher plants. The lysine-sensitive AK isoenzyme is a monofunctional...; Region: AAK_AK-LysC-like; cd04244
546414003773	putative catalytic residues [active]
546414003774	putative nucleotide binding site [chemical binding]; other site
546414003775	aspartate binding site [chemical binding]; other site
546414003776	dimer interface [polypeptide binding]; other site
546414003777	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
546414003778	ACT domains C-terminal to the catalytic domain of aspartokinase (AK; 4-L-aspartate-4-phosphotransferase); Region: ACT_AK-like_2; cd04892
546414003779	PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392
546414003780	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
546414003781	active site
546414003782	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
546414003783	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
546414003784	GIY-YIG motif/motif A; other site
546414003785	active site
546414003786	catalytic site [active]
546414003787	putative DNA binding site [nucleotide binding]; other site
546414003788	metal binding site [ion binding]; metal-binding site
546414003789	UvrB/uvrC motif; Region: UVR; pfam02151
546414003790	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
546414003791	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
546414003792	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
546414003793	dimer interface [polypeptide binding]; other site
546414003794	anticodon binding site; other site
546414003795	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
546414003796	homodimer interface [polypeptide binding]; other site
546414003797	motif 1; other site
546414003798	active site
546414003799	motif 2; other site
546414003800	GAD domain; Region: GAD; pfam02938
546414003801	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
546414003802	active site
546414003803	motif 3; other site
546414003804	histidyl-tRNA synthetase; Region: hisS; TIGR00442
546414003805	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
546414003806	dimer interface [polypeptide binding]; other site
546414003807	motif 1; other site
546414003808	active site
546414003809	motif 2; other site
546414003810	motif 3; other site
546414003811	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
546414003812	anticodon binding site; other site
546414003813	IPT/TIG domain; Region: TIG; pfam01833
546414003814	Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597
546414003815	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
546414003816	Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235
546414003817	site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236
546414003818	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
546414003819	active site
546414003820	catalytic residues [active]
546414003821	DNA binding site [nucleotide binding]
546414003822	Int/Topo IB signature motif; other site
546414003823	apolipoprotein N-acyltransferase; Region: lnt; TIGR00546
546414003824	Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571
546414003825	putative active site [active]
546414003826	catalytic triad [active]
546414003827	putative dimer interface [polypeptide binding]; other site
546414003828	Calcineurin-like phosphoesterase superfamily domain; Region: Metallophos_2; pfam12850
546414003829	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
546414003830	active site
546414003831	metal binding site [ion binding]; metal-binding site
546414003832	Alanine-glyoxylate aminotransferase (AGAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to alanine-glyoxylate aminotransferase (AGAT); Region: AGAT_like; cd06451
546414003833	homodimer interface [polypeptide binding]; other site
546414003834	pyridoxal 5'-phosphate binding site [chemical binding]; other site
546414003835	catalytic residue [active]
546414003836	Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011
546414003837	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
546414003838	motif II; other site
546414003839	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
546414003840	active site
546414003841	Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355
546414003842	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
546414003843	NlpC/P60 family; Region: NLPC_P60; pfam00877
546414003844	L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319
546414003845	L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948
546414003846	active site
546414003847	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
546414003848	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
546414003849	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
546414003850	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
546414003851	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
546414003852	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
546414003853	catalytic site [active]
546414003854	PGAP1-like protein; Region: PGAP1; pfam07819
546414003855	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
546414003856	Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749
546414003857	predicted active site [active]
546414003858	catalytic triad [active]
546414003859	pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343
546414003860	PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP,  present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727
546414003861	active site
546414003862	multimer interface [polypeptide binding]; other site
546414003863	Response regulator receiver domain; Region: Response_reg; pfam00072
546414003864	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
546414003865	active site
546414003866	phosphorylation site [posttranslational modification]
546414003867	intermolecular recognition site; other site
546414003868	dimerization interface [polypeptide binding]; other site
546414003869	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
546414003870	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
546414003871	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
546414003872	Peptidase family M23; Region: Peptidase_M23; pfam01551
546414003873	transcription termination factor Rho; Provisional; Region: rho; PRK09376
546414003874	Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498
546414003875	Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459
546414003876	RNA binding site [nucleotide binding]; other site
546414003877	Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128
546414003878	multimer interface [polypeptide binding]; other site
546414003879	Walker A motif; other site
546414003880	ATP binding site [chemical binding]; other site
546414003881	Walker B motif; other site
546414003882	Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956
546414003883	active site
546414003884	intersubunit interactions; other site
546414003885	catalytic residue [active]
546414003886	isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039
546414003887	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
546414003888	active site
546414003889	HIGH motif; other site
546414003890	nucleotide binding site [chemical binding]; other site
546414003891	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
546414003892	active site
546414003893	KMSKS motif; other site
546414003894	Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961
546414003895	tRNA binding surface [nucleotide binding]; other site
546414003896	anticodon binding site; other site
546414003897	Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645
546414003898	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_5; cd04962
546414003899	N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA; Region: thiol_BshA; TIGR03999
546414003900	succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678
546414003901	CoA binding domain; Region: CoA_binding; pfam02629
546414003902	CoA-ligase; Region: Ligase_CoA; pfam00549
546414003903	succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696
546414003904	ATP-grasp domain; Region: ATP-grasp_2; pfam08442
546414003905	CoA-ligase; Region: Ligase_CoA; pfam00549
546414003906	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
546414003907	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
546414003908	Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092
546414003909	active site
546414003910	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
546414003911	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
546414003912	Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330
546414003913	Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722
546414003914	oligoendopeptidase F; Region: pepF; TIGR00181
546414003915	Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608
546414003916	active site
546414003917	Zn binding site [ion binding]; other site
546414003918	Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724
546414003919	substrate binding site [chemical binding]; other site
546414003920	active site
546414003921	catalytic residues [active]
546414003922	heterodimer interface [polypeptide binding]; other site
546414003923	tryptophan synthase, beta subunit; Region: trpB; TIGR00263
546414003924	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
546414003925	pyridoxal 5'-phosphate binding site [chemical binding]; other site
546414003926	catalytic residue [active]
546414003927	glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710
546414003928	active site
546414003929	HIGH motif; other site
546414003930	nucleotide binding site [chemical binding]; other site
546414003931	active site
546414003932	KMSKS motif; other site
546414003933	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
546414003934	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
546414003935	P-loop; other site
546414003936	Magnesium ion binding site [ion binding]; other site
546414003937	Uncharacterized proteins, LmbE homologs [Function unknown]; Region: COG2120
546414003938	Putative amidotransferase; Region: DUF4066; pfam13278
546414003939	Protein of unknown function (DUF3208); Region: DUF3208; pfam11482
546414003940	AAA ATPase domain; Region: AAA_16; pfam13191
546414003941	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
546414003942	TPR motif; other site
546414003943	binding surface
546414003944	Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597
546414003945	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
546414003946	UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381
546414003947	Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase  family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786
546414003948	active site
546414003949	homodimer interface [polypeptide binding]; other site
546414003950	UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472
546414003951	This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853
546414003952	Mg++ binding site [ion binding]; other site
546414003953	putative catalytic motif [active]
546414003954	substrate binding site [chemical binding]; other site
546414003955	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
546414003956	active site
546414003957	Phosphotransferase enzyme family; Region: APH; pfam01636
546414003958	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
546414003959	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
546414003960	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
546414003961	Zn2+ binding site [ion binding]; other site
546414003962	Mg2+ binding site [ion binding]; other site
546414003963	Flagellin N-methylase; Region: FliB; cl00497
546414003964	Uncharacterized metal-binding protein (DUF2227); Region: DUF2227; cl01017
546414003965	Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922
546414003966	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
546414003967	active site
546414003968	catalytic residues [active]
546414003969	Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288
546414003970	putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823
546414003971	NADP binding site [chemical binding]; other site
546414003972	dimer interface [polypeptide binding]; other site
546414003973	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
546414003974	Domain of unknown function DUF21; Region: DUF21; pfam01595
546414003975	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
546414003976	Transporter associated domain; Region: CorC_HlyC; smart01091
546414003977	Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283
546414003978	active site
546414003979	catalytic motif [active]
546414003980	Zn binding site [ion binding]; other site
546414003981	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
546414003982	PAS fold; Region: PAS_3; pfam08447
546414003983	putative active site [active]
546414003984	heme pocket [chemical binding]; other site
546414003985	PAS domain S-box; Region: sensory_box; TIGR00229
546414003986	PAS domain; Region: PAS; smart00091
546414003987	PAS domain S-box; Region: sensory_box; TIGR00229
546414003988	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
546414003989	putative active site [active]
546414003990	heme pocket [chemical binding]; other site
546414003991	PAS domain S-box; Region: sensory_box; TIGR00229
546414003992	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
546414003993	putative active site [active]
546414003994	heme pocket [chemical binding]; other site
546414003995	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080
546414003996	dimer interface [polypeptide binding]; other site
546414003997	phosphorylation site [posttranslational modification]
546414003998	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
546414003999	ATP binding site [chemical binding]; other site
546414004000	Mg2+ binding site [ion binding]; other site
546414004001	G-X-G motif; other site
546414004002	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
546414004003	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
546414004004	active site
546414004005	phosphorylation site [posttranslational modification]
546414004006	intermolecular recognition site; other site
546414004007	dimerization interface [polypeptide binding]; other site
546414004008	isocitrate lyase; Provisional; Region: PRK15063
546414004009	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
546414004010	tetramer interface [polypeptide binding]; other site
546414004011	active site
546414004012	Mg2+/Mn2+ binding site [ion binding]; other site
546414004013	Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727
546414004014	malate synthase A; Region: malate_syn_A; TIGR01344
546414004015	active site
546414004016	haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509
546414004017	?-D-glucose-1-phosphatase; Provisional; Region: PRK09456
546414004018	Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618
546414004019	DHH family; Region: DHH; pfam01368
546414004020	DHHA1 domain; Region: DHHA1; pfam02272
546414004021	Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354
546414004022	EDD domain protein, DegV family; Region: DegV; TIGR00762
546414004023	Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645
546414004024	Domain of unknown function (DUF1772); Region: DUF1772; cl12097
546414004025	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
546414004026	4Fe-4S binding domain; Region: Fer4; cl02805
546414004027	Cysteine-rich domain; Region: CCG; pfam02754
546414004028	Cysteine-rich domain; Region: CCG; pfam02754
546414004029	MoxR-like ATPases [General function prediction only]; Region: COG0714
546414004030	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
546414004031	Walker A motif; other site
546414004032	ATP binding site [chemical binding]; other site
546414004033	Walker B motif; other site
546414004034	arginine finger; other site
546414004035	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3864
546414004036	Putative metallopeptidase domain; Region: DUF2201_N; pfam13203
546414004037	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
546414004038	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
546414004039	nudix motif; other site
546414004040	ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073
546414004041	Part of AAA domain; Region: AAA_19; pfam13245
546414004042	Family description; Region: UvrD_C_2; pfam13538
546414004043	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
546414004044	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
546414004045	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
546414004046	active site
546414004047	Peptidase M55, D-aminopeptidase dipeptide-binding protein family; Region: DAP_dppA_1; cd08663
546414004048	SxDxEG motif; other site
546414004049	active site
546414004050	metal binding site [ion binding]; metal-binding site
546414004051	homopentamer interface [polypeptide binding]; other site
546414004052	alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561
546414004053	TAP-like protein; Region: Abhydrolase_4; pfam08386
546414004054	Domain of unknown function (DUF4259); Region: DUF4259; pfam14078
546414004055	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
546414004056	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366
546414004057	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
546414004058	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
546414004059	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
546414004060	WHG domain; Region: WHG; pfam13305
546414004061	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
546414004062	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
546414004063	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
546414004064	Walker A/P-loop; other site
546414004065	ATP binding site [chemical binding]; other site
546414004066	Q-loop/lid; other site
546414004067	ABC transporter signature motif; other site
546414004068	Walker B; other site
546414004069	D-loop; other site
546414004070	H-loop/switch region; other site
546414004071	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
546414004072	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
546414004073	Walker A/P-loop; other site
546414004074	ATP binding site [chemical binding]; other site
546414004075	Q-loop/lid; other site
546414004076	ABC transporter signature motif; other site
546414004077	Walker B; other site
546414004078	D-loop; other site
546414004079	H-loop/switch region; other site
546414004080	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
546414004081	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
546414004082	TM-ABC transporter signature motif; other site
546414004083	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
546414004084	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
546414004085	TM-ABC transporter signature motif; other site
546414004086	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
546414004087	Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268
546414004088	ligand binding site [chemical binding]; other site
546414004089	Transcriptional regulators [Transcription]; Region: FadR; COG2186
546414004090	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
546414004091	DNA-binding site [nucleotide binding]; DNA binding site
546414004092	FCD domain; Region: FCD; pfam07729
546414004093	Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101
546414004094	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
546414004095	Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338
546414004096	active site
546414004097	homodimer interface [polypeptide binding]; other site
546414004098	catalytic site [active]
546414004099	NADH-quinone oxidoreductase chain 15; Region: NADH_Oxid_Nqo15; pfam11497
546414004100	Divergent PAP2 family; Region: DUF212; pfam02681
546414004101	bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14173
546414004102	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
546414004103	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
546414004104	homodimer interface [polypeptide binding]; other site
546414004105	NADP binding site [chemical binding]; other site
546414004106	substrate binding site [chemical binding]; other site
546414004107	Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619
546414004108	putative RNA binding site [nucleotide binding]; other site
546414004109	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302
546414004110	NAD-dependent DNA ligase (contains BRCT domain type II) [DNA replication, recombination, and repair]; Region: Lig; COG0272
546414004111	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
546414004112	nucleotide binding pocket [chemical binding]; other site
546414004113	K-X-D-G motif; other site
546414004114	catalytic site [active]
546414004115	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
546414004116	NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119
546414004117	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
546414004118	Dimer interface [polypeptide binding]; other site
546414004119	Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354
546414004120	Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744
546414004121	ligand binding site [chemical binding]; other site
546414004122	PrcB C-terminal; Region: PrcB_C; pfam14343
546414004123	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497
546414004124	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
546414004125	Walker A/P-loop; other site
546414004126	ATP binding site [chemical binding]; other site
546414004127	Q-loop/lid; other site
546414004128	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
546414004129	Q-loop/lid; other site
546414004130	ABC transporter signature motif; other site
546414004131	Walker B; other site
546414004132	D-loop; other site
546414004133	H-loop/switch region; other site
546414004134	Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484
546414004135	Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293
546414004136	active site
546414004137	substrate-binding site [chemical binding]; other site
546414004138	metal-binding site [ion binding]
546414004139	ATP binding site [chemical binding]; other site
546414004140	Predicted phosphohydrolase [General function prediction only]; Region: COG1768
546414004141	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
546414004142	recombination regulator RecX; Provisional; Region: recX; PRK14137
546414004143	RecX family; Region: RecX; cl00936
546414004144	30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239
546414004145	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
546414004146	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
546414004147	DNA-binding site [nucleotide binding]; DNA binding site
546414004148	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
546414004149	pyridoxal 5'-phosphate binding site [chemical binding]; other site
546414004150	homodimer interface [polypeptide binding]; other site
546414004151	catalytic residue [active]
546414004152	3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772
546414004153	tartrate dehydrogenase; Region: TTC; TIGR02089
546414004154	3-isopropylmalate dehydratase small subunit; Reviewed; Region: leuD; PRK00439
546414004155	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
546414004156	substrate binding site [chemical binding]; other site
546414004157	Protein of unknown function (DUF2839); Region: DUF2839; pfam10999
546414004158	3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
546414004159	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
546414004160	substrate binding site [chemical binding]; other site
546414004161	ligand binding site [chemical binding]; other site
546414004162	Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386
546414004163	Succinate:quinone oxidoreductase (SQR) Type A subfamily, Succinate dehydrogenase C (SdhC)-like subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Members of this subfamily reduce low potential...; Region: SQR_TypeA_SdhC_like; cd03501
546414004164	putative Iron-sulfur protein interface [polypeptide binding]; other site
546414004165	putative proximal heme binding site [chemical binding]; other site
546414004166	putative SdhD-like interface [polypeptide binding]; other site
546414004167	putative distal heme binding site [chemical binding]; other site
546414004168	Succinate:quinone oxidoreductase (SQR) Type A subfamily, Succinate dehydrogenase D (SdhD)-like subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Members of this subfamily reduce low potential...; Region: SQR_TypeA_SdhD_like; cd03500
546414004169	putative Iron-sulfur protein interface [polypeptide binding]; other site
546414004170	putative proximal heme binding site [chemical binding]; other site
546414004171	putative SdhC-like subunit interface [polypeptide binding]; other site
546414004172	putative distal heme binding site [chemical binding]; other site
546414004173	succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08205
546414004174	L-aspartate oxidase; Provisional; Region: PRK06175
546414004175	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
546414004176	succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950
546414004177	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085
546414004178	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
546414004179	Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384
546414004180	dimer interface [polypeptide binding]; other site
546414004181	active site
546414004182	Schiff base residues; other site
546414004183	Roadblock/LC7 domain; Region: Robl_LC7; smart00960
546414004184	Roadblock/LC7 domain; Region: Robl_LC7; smart00960
546414004185	Uncharacterized distant relative of homeotic protein bithoraxoid [General function prediction only]; Region: COG2018
546414004186	DNA gyrase subunit A; Validated; Region: PRK05560
546414004187	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
546414004188	CAP-like domain; other site
546414004189	active site
546414004190	primary dimer interface [polypeptide binding]; other site
546414004191	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
546414004192	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
546414004193	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
546414004194	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
546414004195	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
546414004196	CRP/FNR family transcriptional regulator; Provisional; Region: PRK13918
546414004197	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
546414004198	ligand binding site [chemical binding]; other site
546414004199	Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545
546414004200	putative switch regulator; other site
546414004201	non-specific DNA interactions [nucleotide binding]; other site
546414004202	DNA binding site [nucleotide binding]
546414004203	sequence specific DNA binding site [nucleotide binding]; other site
546414004204	putative cAMP binding site [chemical binding]; other site
546414004205	ferredoxin-NADP+ reductase; Region: PLN02852
546414004206	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
546414004207	Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492
546414004208	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
546414004209	Aminoglycoside 3-N-acetyltransferase; Region: Antibiotic_NAT; pfam02522
546414004210	Uncharacterized protein related to glutamine synthetase [General function prediction only]; Region: COG3968
546414004211	Glutamine synthetase type III N terminal; Region: GSIII_N; pfam12437
546414004212	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
546414004213	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
546414004214	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
546414004215	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
546414004216	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
546414004217	Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342
546414004218	dimerization interface [polypeptide binding]; other site
546414004219	ligand binding site [chemical binding]; other site
546414004220	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
546414004221	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
546414004222	TM-ABC transporter signature motif; other site
546414004223	Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454
546414004224	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
546414004225	TM-ABC transporter signature motif; other site
546414004226	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
546414004227	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
546414004228	Walker A/P-loop; other site
546414004229	ATP binding site [chemical binding]; other site
546414004230	Q-loop/lid; other site
546414004231	ABC transporter signature motif; other site
546414004232	Walker B; other site
546414004233	D-loop; other site
546414004234	H-loop/switch region; other site
546414004235	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
546414004236	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
546414004237	Walker A/P-loop; other site
546414004238	ATP binding site [chemical binding]; other site
546414004239	Q-loop/lid; other site
546414004240	ABC transporter signature motif; other site
546414004241	Walker B; other site
546414004242	D-loop; other site
546414004243	H-loop/switch region; other site
546414004244	ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346
546414004245	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
546414004246	Walker A motif; other site
546414004247	ATP binding site [chemical binding]; other site
546414004248	Walker B motif; other site
546414004249	arginine finger; other site
546414004250	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
546414004251	Walker A motif; other site
546414004252	ATP binding site [chemical binding]; other site
546414004253	Walker B motif; other site
546414004254	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
546414004255	HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228
546414004256	nucleotide binding site/active site [active]
546414004257	HIT family signature motif; other site
546414004258	catalytic residue [active]
546414004259	DNA repair protein RadA; Provisional; Region: PRK11823
546414004260	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
546414004261	Walker A motif; other site
546414004262	ATP binding site [chemical binding]; other site
546414004263	Walker B motif; other site
546414004264	Uncharacterized protein conserved in bacteria (DUF2087); Region: DUF2087; pfam09860
546414004265	ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542
546414004266	Clp amino terminal domain; Region: Clp_N; pfam02861
546414004267	Clp amino terminal domain; Region: Clp_N; pfam02861
546414004268	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
546414004269	Walker A motif; other site
546414004270	ATP binding site [chemical binding]; other site
546414004271	Walker B motif; other site
546414004272	arginine finger; other site
546414004273	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
546414004274	Walker A motif; other site
546414004275	ATP binding site [chemical binding]; other site
546414004276	Walker B motif; other site
546414004277	arginine finger; other site
546414004278	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
546414004279	Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599
546414004280	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
546414004281	Ligand binding site [chemical binding]; other site
546414004282	Electron transfer flavoprotein domain; Region: ETF; pfam01012
546414004283	Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025
546414004284	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715
546414004285	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
546414004286	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565
546414004287	classical (c) SDRs; Region: SDR_c; cd05233
546414004288	NAD(P) binding site [chemical binding]; other site
546414004289	active site
546414004290	Disulfide bond formation protein DsbB; Region: DsbB; cl00649
546414004291	Thioredoxin; Region: Thioredoxin_4; pfam13462
546414004292	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
546414004293	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
546414004294	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
546414004295	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
546414004296	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
546414004297	Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092
546414004298	PUA domain; Region: PUA; cl00607
546414004299	Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572
546414004300	putative RNA binding site [nucleotide binding]; other site
546414004301	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
546414004302	S-adenosylmethionine binding site [chemical binding]; other site
546414004303	Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793
546414004304	PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117
546414004305	C-terminal processing peptidase family S41; Region: Peptidase_S41; cd06567
546414004306	Active site serine [active]
546414004307	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
546414004308	Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861
546414004309	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
546414004310	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
546414004311	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
546414004312	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
546414004313	diaminopimelate decarboxylase; Region: lysA; TIGR01048
546414004314	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
546414004315	active site
546414004316	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
546414004317	substrate binding site [chemical binding]; other site
546414004318	catalytic residues [active]
546414004319	dimer interface [polypeptide binding]; other site
546414004320	tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054
546414004321	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
546414004322	Ligand Binding Site [chemical binding]; other site
546414004323	Putative D-isomer specific 2-hydroxyacid dehydrogenase; Region: 2-Hacid_dh_1; cd05300
546414004324	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
546414004325	NAD binding site [chemical binding]; other site
546414004326	ligand binding site [chemical binding]; other site
546414004327	catalytic site [active]
546414004328	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
546414004329	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
546414004330	CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638
546414004331	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
546414004332	active site
546414004333	Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177
546414004334	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
546414004335	minor groove reading motif; other site
546414004336	helix-hairpin-helix signature motif; other site
546414004337	substrate binding pocket [chemical binding]; other site
546414004338	active site
546414004339	iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525
546414004340	ATP phosphoribosyltransferase, regulatory subunit; Region: hisZ_biosyn_reg; TIGR00443
546414004341	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
546414004342	dimer interface [polypeptide binding]; other site
546414004343	motif 1; other site
546414004344	active site
546414004345	motif 2; other site
546414004346	motif 3; other site
546414004347	ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686
546414004348	ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040
546414004349	Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168
546414004350	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
546414004351	pyridoxal 5'-phosphate binding site [chemical binding]; other site
546414004352	homodimer interface [polypeptide binding]; other site
546414004353	catalytic residue [active]
546414004354	5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584
546414004355	5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704
546414004356	LrgA family; Region: LrgA; pfam03788
546414004357	Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346
546414004358	transcriptional repressor BetI; Region: betaine_BetI; TIGR03384
546414004359	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
546414004360	Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977
546414004361	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
546414004362	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
546414004363	intersubunit interface [polypeptide binding]; other site
546414004364	superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280
546414004365	heme-binding site [chemical binding]; other site
546414004366	Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018
546414004367	tandem repeat interface [polypeptide binding]; other site
546414004368	oligomer interface [polypeptide binding]; other site
546414004369	active site residues [active]
546414004370	signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706
546414004371	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
546414004372	tandem repeat interface [polypeptide binding]; other site
546414004373	oligomer interface [polypeptide binding]; other site
546414004374	active site residues [active]
546414004375	oligoendopeptidase, pepF/M3 family; Region: M3_fam_3; TIGR02290
546414004376	Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_2; cd09607
546414004377	active site
546414004378	Zn binding site [ion binding]; other site
546414004379	phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135
546414004380	PhoU domain; Region: PhoU; pfam01895
546414004381	PhoU domain; Region: PhoU; pfam01895
546414004382	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
546414004383	uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926
546414004384	Carboxymuconolactone decarboxylase family; Region: CMD; cl00460
546414004385	signal recognition particle protein; Provisional; Region: PRK10867
546414004386	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
546414004387	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
546414004388	P loop; other site
546414004389	GTP binding site [chemical binding]; other site
546414004390	Signal peptide binding domain; Region: SRP_SPB; pfam02978
546414004391	phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189
546414004392	Int/Topo IB signature motif; other site
546414004393	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200
546414004394	Bacterial Ig-like domain; Region: Big_5; pfam13205
546414004395	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200
546414004396	Domain of unknown function (DUF927); Region: DUF927; cl12098
546414004397	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
546414004398	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
546414004399	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836
546414004400	Nitric oxide synthase (NOS) produces nitric oxide (NO) by catalyzing a five-electron heme-based oxidation of a guanidine nitrogen of L-arginine to L-citrulline via two successive monooxygenation reactions producing N(omega)-hydroxy-L-arginine (NHA) as an...; Region: NOS_oxygenase; cl00254
546414004401	active site
546414004402	dimer interface [polypeptide binding]; other site
546414004403	Barstar_evA4336-like contains uncharacterized sequences similar to the uncharacterized, predicted RNAase inhibitor evA4336 found in Azoarcus sp. EvN1. This is a subfamily of the Barstar family of RNAase inhibitors. Barstar is an intracellular inhibitor...; Region: Barstar_evA4336-like; cd05141
546414004404	putative RNAase interaction site [polypeptide binding]; other site
546414004405	RNase_Sa. Ribonucleases first isolated from Streptomyces aureofaciens. In general, ribonucleases cleave phosphodiester bonds in RNA and are essential  for both non-specific RNA degradation and for numerous forms of RNA processing. RNAse Sa is a guanylate...; Region: RNase_Sa; cd00607
546414004406	active site
546414004407	barstar interaction site; other site
546414004408	Protein of unknown function (DUF3445); Region: DUF3445; pfam11927
546414004409	undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281
546414004410	Aminoglycoside/hydroxyurea antibiotic resistance kinase; Region: APH_6_hur; cl17810
546414004411	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
546414004412	rRNA interaction site [nucleotide binding]; other site
546414004413	S8 interaction site; other site
546414004414	putative laminin-1 binding site; other site
546414004415	elongation factor Ts; Provisional; Region: tsf; PRK09377
546414004416	UBA/TS-N domain; Region: UBA; pfam00627
546414004417	Elongation factor TS; Region: EF_TS; pfam00889
546414004418	Elongation factor TS; Region: EF_TS; pfam00889
546414004419	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
546414004420	putative nucleotide binding site [chemical binding]; other site
546414004421	uridine monophosphate binding site [chemical binding]; other site
546414004422	homohexameric interface [polypeptide binding]; other site
546414004423	ribosome recycling factor; Reviewed; Region: frr; PRK00083
546414004424	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520
546414004425	hinge region; other site
546414004426	CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575
546414004427	Cytidylyltransferase family; Region: CTP_transf_1; pfam01148
546414004428	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447
546414004429	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670
546414004430	1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436
546414004431	DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288
546414004432	Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750
546414004433	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
546414004434	active site
546414004435	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
546414004436	protein binding site [polypeptide binding]; other site
546414004437	Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020
546414004438	putative substrate binding region [chemical binding]; other site
546414004439	Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787
546414004440	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430
546414004441	active site
546414004442	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
546414004443	dimer interface [polypeptide binding]; other site
546414004444	substrate binding site [chemical binding]; other site
546414004445	catalytic residues [active]
546414004446	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
546414004447	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
546414004448	Walker A/P-loop; other site
546414004449	ATP binding site [chemical binding]; other site
546414004450	Q-loop/lid; other site
546414004451	ABC transporter signature motif; other site
546414004452	Walker B; other site
546414004453	D-loop; other site
546414004454	H-loop/switch region; other site
546414004455	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
546414004456	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
546414004457	FtsX-like permease family; Region: FtsX; pfam02687
546414004458	Protein of unknown function (DUF4127); Region: DUF4127; pfam13552
546414004459	EamA-like transporter family; Region: EamA; pfam00892
546414004460	DOMON-like domain of various glycoside hydrolases; Region: DOMON_glucodextranase_like; cd09626
546414004461	putative ligand binding site [chemical binding]; other site
546414004462	gamma-glutamyl kinase; Provisional; Region: PRK05429
546414004463	AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242
546414004464	nucleotide binding site [chemical binding]; other site
546414004465	homotetrameric interface [polypeptide binding]; other site
546414004466	putative phosphate binding site [ion binding]; other site
546414004467	putative allosteric binding site; other site
546414004468	PUA domain; Region: PUA; pfam01472
546414004469	5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737
546414004470	Bacillus subtilis YhcR endonuclease and related proteins, N-terminal metallophosphatase domain; Region: MPP_YhcR_N; cd07412
546414004471	putative active site [active]
546414004472	putative metal binding site [ion binding]; other site
546414004473	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
546414004474	Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain [General function prediction only]; Region: COG2872
546414004475	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973
546414004476	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
546414004477	classical (c) SDRs; Region: SDR_c; cd05233
546414004478	NAD(P) binding site [chemical binding]; other site
546414004479	active site
546414004480	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
546414004481	Moco binding site; other site
546414004482	metal coordination site [ion binding]; other site
546414004483	Domain of unknown function (DUF4397); Region: DUF4397; pfam14344
546414004484	Domain of unknown function (DUF4397); Region: DUF4397; pfam14344
546414004485	Tandem repeat subunit of reelin and related proteins; Region: Reelin_subrepeat_like; cl15240
546414004486	Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132
546414004487	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
546414004488	Multicopper oxidase; Region: Cu-oxidase; pfam00394
546414004489	Cupredoxin-like domain; Region: Cupredoxin_1; cl17234
546414004490	Major Facilitator Superfamily; Region: MFS_1; pfam07690
546414004491	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
546414004492	putative substrate translocation pore; other site
546414004493	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
546414004494	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
546414004495	MarR family; Region: MarR_2; pfam12802
546414004496	Lysine biosynthesis enzyme LysX; Region: LysX_arch; TIGR02144
546414004497	ATP-grasp domain; Region: ATP-grasp_4; cl17255
546414004498	lysine biosynthesis protein LysW; Region: lysW; TIGR01206
546414004499	homoaconitate hydratase small subunit; Provisional; Region: PRK14023
546414004500	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
546414004501	substrate binding site [chemical binding]; other site
546414004502	3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
546414004503	Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285
546414004504	substrate binding site [chemical binding]; other site
546414004505	ligand binding site [chemical binding]; other site
546414004506	Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels [Inorganic ion transport and metabolism]; Region: COG0490
546414004507	TrkA-C domain; Region: TrkA_C; pfam02080
546414004508	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
546414004509	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
546414004510	YciF bacterial stress response protein, ferritin-like iron-binding domain; Region: YciF; cd07909
546414004511	dimerization interface [polypeptide binding]; other site
546414004512	metal binding site [ion binding]; metal-binding site
546414004513	Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004
546414004514	Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347
546414004515	Nitrogen regulatory protein P-II; Region: P-II; smart00938
546414004516	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
546414004517	Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729
546414004518	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
546414004519	FeS/SAM binding site; other site
546414004520	Methyltransferase domain; Region: Methyltransf_11; pfam08241
546414004521	L-aspartate oxidase; Provisional; Region: PRK07512
546414004522	L-aspartate oxidase; Provisional; Region: PRK06175
546414004523	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
546414004524	Nicotinate-nucleotide pyrophosphorylase [Coenzyme metabolism]; Region: NadC; COG0157
546414004525	Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572
546414004526	dimerization interface [polypeptide binding]; other site
546414004527	active site
546414004528	Quinolinate synthetase A protein; Region: NadA; pfam02445
546414004529	isocitrate dehydrogenase; Validated; Region: PRK07362
546414004530	isocitrate dehydrogenase; Reviewed; Region: PRK07006
546414004531	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
546414004532	dimer interface [polypeptide binding]; other site
546414004533	conserved gate region; other site
546414004534	putative PBP binding loops; other site
546414004535	ABC-ATPase subunit interface; other site
546414004536	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
546414004537	ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism]; Region: UgpA; COG1175
546414004538	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
546414004539	putative PBP binding loops; other site
546414004540	dimer interface [polypeptide binding]; other site
546414004541	ABC-ATPase subunit interface; other site
546414004542	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
546414004543	nudix motif; other site
546414004544	FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831
546414004545	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
546414004546	Protein of unknown function (DUF4127); Region: DUF4127; pfam13552
546414004547	N-acetylmannosamine kinase; Provisional; Region: PRK05082
546414004548	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
546414004549	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
546414004550	1-pyrroline-5-carboxylate dehydrogenase; Provisional; Region: PRK03137
546414004551	Delta(1)-pyrroline-5-carboxylate dehydrogenase, RocA; Region: ALDH_PutA-P5CDH-RocA; cd07124
546414004552	Glutamate binding site [chemical binding]; other site
546414004553	homodimer interface [polypeptide binding]; other site
546414004554	NAD binding site [chemical binding]; other site
546414004555	catalytic residues [active]
546414004556	DinB superfamily; Region: DinB_2; pfam12867
546414004557	DinB superfamily; Region: DinB_2; pfam12867
546414004558	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
546414004559	Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161
546414004560	inhibitor-cofactor binding pocket; inhibition site
546414004561	pyridoxal 5'-phosphate binding site [chemical binding]; other site
546414004562	catalytic residue [active]
546414004563	Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922
546414004564	The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533
546414004565	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
546414004566	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
546414004567	ligand binding site [chemical binding]; other site
546414004568	flexible hinge region; other site
546414004569	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
546414004570	non-specific DNA interactions [nucleotide binding]; other site
546414004571	DNA binding site [nucleotide binding]
546414004572	sequence specific DNA binding site [nucleotide binding]; other site
546414004573	putative cAMP binding site [chemical binding]; other site
546414004574	bacillithiol biosynthesis cysteine-adding enzyme BshC; Region: thiol_BshC; TIGR03998
546414004575	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4365
546414004576	signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416
546414004577	SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881
546414004578	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
546414004579	P loop; other site
546414004580	GTP binding site [chemical binding]; other site
546414004581	NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976
546414004582	catalytic residues [active]
546414004583	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
546414004584	Catalytic domain of Protein Kinases; Region: PKc; cd00180
546414004585	active site
546414004586	ATP binding site [chemical binding]; other site
546414004587	substrate binding site [chemical binding]; other site
546414004588	activation loop (A-loop); other site
546414004589	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
546414004590	active site
546414004591	Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345
546414004592	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232
546414004593	ribosomal protein L11 methyltransferase; Reviewed; Region: prmA; PRK00517
546414004594	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
546414004595	S-adenosylmethionine binding site [chemical binding]; other site
546414004596	16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713
546414004597	Recombinational DNA repair protein (RecF pathway) [DNA replication, recombination, and repair]; Region: RecO; COG1381
546414004598	Recombination protein O N terminal; Region: RecO_N; pfam11967
546414004599	Recombination protein O C terminal; Region: RecO_C; pfam02565
546414004600	Transcriptional regulators [Transcription]; Region: GntR; COG1802
546414004601	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
546414004602	DNA-binding site [nucleotide binding]; DNA binding site
546414004603	FCD domain; Region: FCD; cl11656
546414004604	Proline dehydrogenase; Region: Pro_dh; cl03282
546414004605	1-pyrroline-5-carboxylate dehydrogenase; Provisional; Region: PRK03137
546414004606	Delta(1)-pyrroline-5-carboxylate dehydrogenase, RocA; Region: ALDH_PutA-P5CDH-RocA; cd07124
546414004607	Glutamate binding site [chemical binding]; other site
546414004608	homodimer interface [polypeptide binding]; other site
546414004609	NAD binding site [chemical binding]; other site
546414004610	catalytic residues [active]
546414004611	Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233
546414004612	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
546414004613	prenyltransferase; Provisional; Region: ubiA; PRK13595
546414004614	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
546414004615	active site
546414004616	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
546414004617	active site
546414004618	Domain of unknown function (DUF4395); Region: DUF4395; pfam14340
546414004619	Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155
546414004620	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
546414004621	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
546414004622	Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027
546414004623	ligand-binding site [chemical binding]; other site
546414004624	3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175
546414004625	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
546414004626	Active Sites [active]
546414004627	sulfate adenylyltransferase; Reviewed; Region: sat; PRK04149
546414004628	ATP-sulfurylase; Region: ATPS; cd00517
546414004629	active site
546414004630	HXXH motif; other site
546414004631	flexible loop; other site
546414004632	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
546414004633	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
546414004634	substrate binding pocket [chemical binding]; other site
546414004635	membrane-bound complex binding site; other site
546414004636	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
546414004637	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
546414004638	dimer interface [polypeptide binding]; other site
546414004639	conserved gate region; other site
546414004640	putative PBP binding loops; other site
546414004641	ABC-ATPase subunit interface; other site
546414004642	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
546414004643	nitrate transport ATP-binding subunits C and D; Region: ntrCD; TIGR01184
546414004644	Walker A/P-loop; other site
546414004645	ATP binding site [chemical binding]; other site
546414004646	Q-loop/lid; other site
546414004647	ABC transporter signature motif; other site
546414004648	Walker B; other site
546414004649	D-loop; other site
546414004650	H-loop/switch region; other site
546414004651	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
546414004652	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
546414004653	Saccharomyces cerevisiae homocitrate synthase and related proteins, catalytic TIM barrel domain; Region: DRE_TIM_HCS; cd07948
546414004654	homocitrate synthase; Region: LysS_fung_arch; TIGR02146
546414004655	active site
546414004656	catalytic residues [active]
546414004657	metal binding site [ion binding]; metal-binding site
546414004658	Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384
546414004659	benzoate transporter; Region: benE; TIGR00843
546414004660	ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14468
546414004661	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
546414004662	FeS/SAM binding site; other site
546414004663	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
546414004664	TPR motif; other site
546414004665	binding surface
546414004666	TPR repeat; Region: TPR_11; pfam13414
546414004667	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
546414004668	binding surface
546414004669	TPR motif; other site
546414004670	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
546414004671	TPR motif; other site
546414004672	binding surface
546414004673	Sporulation related domain; Region: SPOR; pfam05036
546414004674	Sporulation related domain; Region: SPOR; pfam05036
546414004675	redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472
546414004676	Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971
546414004677	CoA binding domain; Region: CoA_binding; smart00881
546414004678	bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase periplasmic precursor protein; Reviewed; Region: cpdB; PRK09420
546414004679	Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410
546414004680	active site
546414004681	metal binding site [ion binding]; metal-binding site
546414004682	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
546414004683	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
546414004684	FAD binding domain; Region: FAD_binding_4; pfam01565
546414004685	glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387
546414004686	glycolate oxidase iron-sulfur subunit; Provisional; Region: glcF; PRK11274
546414004687	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
546414004688	Cysteine-rich domain; Region: CCG; pfam02754
546414004689	Cysteine-rich domain; Region: CCG; pfam02754
546414004690	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
546414004691	Major Facilitator Superfamily; Region: MFS_1; pfam07690
546414004692	putative substrate translocation pore; other site
546414004693	Phospholipid methyltransferase; Region: PEMT; cl17370
546414004694	Putative periplasmic protein kinase ArgK and related GTPases of G3E family [Amino acid transport and metabolism]; Region: ArgK; COG1703
546414004695	The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114
546414004696	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
546414004697	G4 box; other site
546414004698	G5 box; other site
546414004699	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
546414004700	catalytic core [active]
546414004701	phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385
546414004702	PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196
546414004703	dimerization interface [polypeptide binding]; other site
546414004704	putative ATP binding site [chemical binding]; other site
546414004705	Uncharacterized conserved protein [Function unknown]; Region: COG0398
546414004706	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
546414004707	putative hydrolase; Provisional; Region: PRK02113
546414004708	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
546414004709	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
546414004710	active site
546414004711	ribulose/triose binding site [chemical binding]; other site
546414004712	phosphate binding site [ion binding]; other site
546414004713	substrate (anthranilate) binding pocket [chemical binding]; other site
546414004714	product (indole) binding pocket [chemical binding]; other site
546414004715	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
546414004716	active site
546414004717	leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
546414004718	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
546414004719	HIGH motif; other site
546414004720	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
546414004721	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
546414004722	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
546414004723	active site
546414004724	KMSKS motif; other site
546414004725	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
546414004726	tRNA binding surface [nucleotide binding]; other site
546414004727	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
546414004728	CAAX protease self-immunity; Region: Abi; pfam02517
546414004729	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
546414004730	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
546414004731	substrate binding pocket [chemical binding]; other site
546414004732	chain length determination region; other site
546414004733	substrate-Mg2+ binding site; other site
546414004734	catalytic residues [active]
546414004735	aspartate-rich region 1; other site
546414004736	active site lid residues [active]
546414004737	aspartate-rich region 2; other site
546414004738	N-formylglutamate amidohydrolase; Region: FGase; cl01522
546414004739	recombination protein F; Provisional; Region: recF; PRK14079
546414004740	ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242
546414004741	Walker A/P-loop; other site
546414004742	ATP binding site [chemical binding]; other site
546414004743	Q-loop/lid; other site
546414004744	Protein of unknown function (DUF721); Region: DUF721; cl02324
546414004745	MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886
546414004746	MPT binding site; other site
546414004747	trimer interface [polypeptide binding]; other site
546414004748	tRNA pseudouridine synthase D (TruD); Region: TruD; pfam01142
546414004749	Pseudouridine synthase, similar to Escherichia coli TruD; Region: PseudoU_synth_EcTruD; cd02575
546414004750	Permutation of conserved domain; other site
546414004751	active site
546414004752	Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130
546414004753	Protein of unknown function (DUF3293); Region: DUF3293; pfam11697
546414004754	Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865
546414004755	ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749
546414004756	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
546414004757	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
546414004758	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
546414004759	dimer interface [polypeptide binding]; other site
546414004760	conserved gate region; other site
546414004761	putative PBP binding loops; other site
546414004762	ABC-ATPase subunit interface; other site
546414004763	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
546414004764	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
546414004765	dimer interface [polypeptide binding]; other site
546414004766	conserved gate region; other site
546414004767	putative PBP binding loops; other site
546414004768	ABC-ATPase subunit interface; other site
546414004769	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
546414004770	Protein of unknown function DUF58; Region: DUF58; pfam01882
546414004771	MoxR-like ATPases [General function prediction only]; Region: COG0714
546414004772	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
546414004773	ATP binding site [chemical binding]; other site
546414004774	Walker A motif; other site
546414004775	Walker B motif; other site
546414004776	arginine finger; other site
546414004777	Domain of unknown function (DUF4129); Region: DUF4129; pfam13559
546414004778	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
546414004779	RNA polymerase sigma factor RpoD, C-terminal domain; Region: RpoD_Cterm; TIGR02393
546414004780	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
546414004781	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
546414004782	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
546414004783	DNA binding residues [nucleotide binding]
546414004784	16S RNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; Region: RsmC; COG2813
546414004785	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
546414004786	S-adenosylmethionine binding site [chemical binding]; other site
546414004787	Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541
546414004788	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
546414004789	acyl-activating enzyme (AAE) consensus motif; other site
546414004790	active site
546414004791	AMP binding site [chemical binding]; other site
546414004792	CoA binding site [chemical binding]; other site
546414004793	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
546414004794	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
546414004795	Walker A/P-loop; other site
546414004796	ATP binding site [chemical binding]; other site
546414004797	Q-loop/lid; other site
546414004798	ABC transporter signature motif; other site
546414004799	Walker B; other site
546414004800	D-loop; other site
546414004801	H-loop/switch region; other site
546414004802	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
546414004803	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
546414004804	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
546414004805	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
546414004806	TM-ABC transporter signature motif; other site
546414004807	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
546414004808	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
546414004809	TM-ABC transporter signature motif; other site
546414004810	Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022
546414004811	Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907
546414004812	acyl-activating enzyme (AAE) consensus motif; other site
546414004813	putative AMP binding site [chemical binding]; other site
546414004814	putative active site [active]
546414004815	putative CoA binding site [chemical binding]; other site
546414004816	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
546414004817	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
546414004818	Walker A/P-loop; other site
546414004819	ATP binding site [chemical binding]; other site
546414004820	Q-loop/lid; other site
546414004821	ABC transporter signature motif; other site
546414004822	Walker B; other site
546414004823	D-loop; other site
546414004824	H-loop/switch region; other site
546414004825	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
546414004826	acyl-CoA synthetase; Validated; Region: PRK08162
546414004827	acyl-activating enzyme (AAE) consensus motif; other site
546414004828	AMP binding site [chemical binding]; other site
546414004829	active site
546414004830	CoA binding site [chemical binding]; other site
546414004831	Tetratricopeptide repeat; Region: TPR_12; pfam13424
546414004832	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
546414004833	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
546414004834	metal binding site [ion binding]; metal-binding site
546414004835	active site
546414004836	I-site; other site
546414004837	bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
546414004838	RNA/DNA hybrid binding site [nucleotide binding]; other site
546414004839	active site
546414004840	GTP-binding protein LepA; Provisional; Region: PRK05433
546414004841	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
546414004842	G1 box; other site
546414004843	putative GEF interaction site [polypeptide binding]; other site
546414004844	GTP/Mg2+ binding site [chemical binding]; other site
546414004845	Switch I region; other site
546414004846	G2 box; other site
546414004847	G3 box; other site
546414004848	Switch II region; other site
546414004849	G4 box; other site
546414004850	G5 box; other site
546414004851	lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699
546414004852	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
546414004853	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
546414004854	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
546414004855	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
546414004856	dimer interface [polypeptide binding]; other site
546414004857	phosphorylation site [posttranslational modification]
546414004858	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
546414004859	ATP binding site [chemical binding]; other site
546414004860	Mg2+ binding site [ion binding]; other site
546414004861	G-X-G motif; other site
546414004862	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
546414004863	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
546414004864	active site
546414004865	phosphorylation site [posttranslational modification]
546414004866	intermolecular recognition site; other site
546414004867	dimerization interface [polypeptide binding]; other site
546414004868	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
546414004869	DNA binding residues [nucleotide binding]
546414004870	dimerization interface [polypeptide binding]; other site
546414004871	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
546414004872	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
546414004873	metal binding site [ion binding]; metal-binding site
546414004874	active site
546414004875	I-site; other site
546414004876	aspartate aminotransferase; Provisional; Region: PRK05764
546414004877	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
546414004878	pyridoxal 5'-phosphate binding site [chemical binding]; other site
546414004879	homodimer interface [polypeptide binding]; other site
546414004880	catalytic residue [active]
546414004881	Uncharacterized conserved protein [Function unknown]; Region: COG2013
546414004882	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
546414004883	active site
546414004884	homodimer interface [polypeptide binding]; other site
546414004885	UDP-N-acetylmuramate--alanine ligase; Region: murC; TIGR01082
546414004886	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
546414004887	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
546414004888	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
546414004889	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: PRK14651
546414004890	FAD binding domain; Region: FAD_binding_4; pfam01565
546414004891	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
546414004892	Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589
546414004893	POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478
546414004894	Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849
546414004895	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
546414004896	nucleotide binding site [chemical binding]; other site
546414004897	SHS2 domain inserted in FTSA; Region: SHS2_FTSA; pfam02491
546414004898	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
546414004899	Cell division protein FtsA; Region: FtsA; pfam14450
546414004900	cell division protein FtsZ; Validated; Region: PRK09330
546414004901	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
546414004902	nucleotide binding site [chemical binding]; other site
546414004903	SulA interaction site; other site
546414004904	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
546414004905	Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342
546414004906	dimerization interface [polypeptide binding]; other site
546414004907	ligand binding site [chemical binding]; other site
546414004908	6-phosphofructokinase; Provisional; Region: PRK03202
546414004909	6-phosphofructokinase; Region: PFKA_ATP; TIGR02482
546414004910	active site
546414004911	ADP/pyrophosphate binding site [chemical binding]; other site
546414004912	dimerization interface [polypeptide binding]; other site
546414004913	allosteric effector site; other site
546414004914	fructose-1,6-bisphosphate binding site; other site
546414004915	Predicted methyltransferases [General function prediction only]; Region: COG0313
546414004916	Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648
546414004917	putative SAM binding site [chemical binding]; other site
546414004918	putative homodimer interface [polypeptide binding]; other site
546414004919	Uncharacterized conserved protein [Function unknown]; Region: COG1576
546414004920	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
546414004921	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
546414004922	phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK14655
546414004923	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
546414004924	Mg++ binding site [ion binding]; other site
546414004925	putative catalytic motif [active]
546414004926	putative substrate binding site [chemical binding]; other site
546414004927	Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092
546414004928	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
546414004929	Protein of unknown function (DUF2847); Region: DUF2847; pfam11009
546414004930	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
546414004931	dimerization interface [polypeptide binding]; other site
546414004932	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
546414004933	hydrophobic ligand binding site; other site
546414004934	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
546414004935	dimerization interface [polypeptide binding]; other site
546414004936	putative DNA binding site [nucleotide binding]; other site
546414004937	putative Zn2+ binding site [ion binding]; other site
546414004938	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
546414004939	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
546414004940	Zn2+ binding site [ion binding]; other site
546414004941	Mg2+ binding site [ion binding]; other site
546414004942	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
546414004943	synthetase active site [active]
546414004944	NTP binding site [chemical binding]; other site
546414004945	metal binding site [ion binding]; metal-binding site
546414004946	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
546414004947	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
546414004948	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
546414004949	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
546414004950	Walker A/P-loop; other site
546414004951	ATP binding site [chemical binding]; other site
546414004952	Q-loop/lid; other site
546414004953	ABC transporter signature motif; other site
546414004954	Walker B; other site
546414004955	D-loop; other site
546414004956	H-loop/switch region; other site
546414004957	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
546414004958	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
546414004959	Walker A/P-loop; other site
546414004960	ATP binding site [chemical binding]; other site
546414004961	Q-loop/lid; other site
546414004962	ABC transporter signature motif; other site
546414004963	Walker B; other site
546414004964	D-loop; other site
546414004965	H-loop/switch region; other site
546414004966	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
546414004967	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
546414004968	TM-ABC transporter signature motif; other site
546414004969	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
546414004970	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
546414004971	TM-ABC transporter signature motif; other site
546414004972	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
546414004973	Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268
546414004974	ligand binding site [chemical binding]; other site
546414004975	homoserine O-acetyltransferase; Provisional; Region: PRK06765
546414004976	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
546414004977	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
546414004978	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
546414004979	Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788
546414004980	3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428
546414004981	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
546414004982	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
546414004983	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
546414004984	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
546414004985	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
546414004986	Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799
546414004987	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
546414004988	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
546414004989	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
546414004990	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
546414004991	active site
546414004992	Bacterial transcriptional activator domain; Region: BTAD; smart01043
546414004993	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
546414004994	3-hydroxybutyrate dehydrogenase; Region: PHB_DH; TIGR01963
546414004995	NAD(P) binding site [chemical binding]; other site
546414004996	active site
546414004997	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
546414004998	Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339
546414004999	Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456
546414005000	active site
546414005001	Zn binding site [ion binding]; other site
546414005002	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147
546414005003	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113
546414005004	Uncharacterized conserved protein [Function unknown]; Region: COG1432
546414005005	LabA_like proteins; Region: LabA; cd10911
546414005006	putative metal binding site [ion binding]; other site
546414005007	Alanine-glyoxylate amino-transferase; Region: Aminotran_MocR; pfam12897
546414005008	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
546414005009	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
546414005010	catalytic residue [active]
546414005011	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
546414005012	MarR family; Region: MarR; pfam01047
546414005013	MarR family; Region: MarR_2; cl17246
546414005014	Predicted secreted protein (DUF2259); Region: DUF2259; cl02309
546414005015	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
546414005016	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
546414005017	Catalytic site [active]
546414005018	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
546414005019	nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651
546414005020	active site
546414005021	tetramer interface [polypeptide binding]; other site
546414005022	Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding); Region: MPN_like; cd08070
546414005023	MPN+ (JAMM) motif; other site
546414005024	Zinc-binding site [ion binding]; other site
546414005025	DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674
546414005026	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
546414005027	This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843
546414005028	Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335
546414005029	Fasciclin domain; Region: Fasciclin; pfam02469
546414005030	Fasciclin domain; Region: Fasciclin; pfam02469
546414005031	Fasciclin domain; Region: Fasciclin; pfam02469
546414005032	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
546414005033	phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144
546414005034	active site
546414005035	metal binding site [ion binding]; metal-binding site
546414005036	ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668
546414005037	ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866
546414005038	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
546414005039	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
546414005040	Walker A/P-loop; other site
546414005041	ATP binding site [chemical binding]; other site
546414005042	Q-loop/lid; other site
546414005043	ABC transporter signature motif; other site
546414005044	Walker B; other site
546414005045	D-loop; other site
546414005046	H-loop/switch region; other site
546414005047	Family 41 Carbohydrate-Binding Module from pullulanase-like enzymes; Region: CBM41_pullulanase; cd10315
546414005048	carbohydrate binding site [chemical binding]; other site
546414005049	Family 41 Carbohydrate-Binding Module from pullulanase-like enzymes; Region: CBM41_pullulanase; cd10315
546414005050	carbohydrate binding site [chemical binding]; other site
546414005051	Family 41 Carbohydrate-Binding Module from pullulanase-like enzymes; Region: CBM41_pullulanase; cd10315
546414005052	carbohydrate binding site [chemical binding]; other site
546414005053	alpha-1,6-glucosidases, pullulanase-type; Region: pullul_strch; TIGR02103
546414005054	Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860
546414005055	Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341
546414005056	Ca binding site [ion binding]; other site
546414005057	active site
546414005058	catalytic site [active]
546414005059	Domain of unknown function (DUF3372); Region: DUF3372; pfam11852
546414005060	Protein of unknown function (DUF970); Region: DUF970; pfam06153
546414005061	5'-3' exonuclease; Region: 53EXOc; smart00475
546414005062	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
546414005063	active site
546414005064	metal binding site 1 [ion binding]; metal-binding site
546414005065	putative 5' ssDNA interaction site; other site
546414005066	metal binding site 3; metal-binding site
546414005067	metal binding site 2 [ion binding]; metal-binding site
546414005068	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
546414005069	putative DNA binding site [nucleotide binding]; other site
546414005070	putative metal binding site [ion binding]; other site
546414005071	DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012
546414005072	DNA polymerase I; Provisional; Region: PRK05755
546414005073	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
546414005074	active site
546414005075	DNA binding site [nucleotide binding]
546414005076	catalytic site [active]
546414005077	phosphoglucosamine mutase; Provisional; Region: glmM; PRK14323
546414005078	GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802
546414005079	active site
546414005080	substrate binding site [chemical binding]; other site
546414005081	metal binding site [ion binding]; metal-binding site
546414005082	Phosphotransferase enzyme family; Region: APH; pfam01636
546414005083	Ecdysteroid kinase; Region: EcKinase; cl17738
546414005084	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214
546414005085	Protein of unknown function (DUF1006); Region: DUF1006; pfam06224
546414005086	NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171
546414005087	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
546414005088	homodimer interface [polypeptide binding]; other site
546414005089	NAD binding pocket [chemical binding]; other site
546414005090	ATP binding pocket [chemical binding]; other site
546414005091	Mg binding site [ion binding]; other site
546414005092	active-site loop [active]
546414005093	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
546414005094	short chain dehydrogenase; Provisional; Region: PRK06181
546414005095	NAD(P) binding site [chemical binding]; other site
546414005096	active site
546414005097	Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276
546414005098	nucleotide binding site/active site [active]
546414005099	HIT family signature motif; other site
546414005100	catalytic residue [active]
546414005101	Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637
546414005102	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
546414005103	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
546414005104	motif II; other site
546414005105	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
546414005106	Predicted transcriptional regulators [Transcription]; Region: COG1695
546414005107	L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760
546414005108	Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313
546414005109	Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332
546414005110	active sites [active]
546414005111	tetramer interface [polypeptide binding]; other site
546414005112	imidazolonepropionase; Validated; Region: PRK09356
546414005113	Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296
546414005114	active site
546414005115	agmatinase; Region: agmatinase; TIGR01230
546414005116	Arginase-like and histone-like hydrolases; Region: Arginase_HDAC; cl17011
546414005117	active site
546414005118	metal binding site [ion binding]; metal-binding site
546414005119	urocanate hydratase; Provisional; Region: PRK05414
546414005120	Transcriptional regulator [Transcription]; Region: IclR; COG1414
546414005121	IclR helix-turn-helix domain; Region: HTH_IclR; cl17605
546414005122	Bacterial transcriptional regulator; Region: IclR; pfam01614
546414005123	L-serine dehydratase, iron-sulfur-dependent, beta subunit; Region: sda_beta; TIGR00719
546414005124	Serine dehydratase beta chain; Region: SDH_beta; pfam03315
546414005125	C-terminal ACT domain of the L-serine dehydratase (LSD), iron-sulfur-dependent, beta subunit; Region: ACT_LSD; cd04903
546414005126	putative L-serine binding site [chemical binding]; other site
546414005127	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
546414005128	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
546414005129	substrate binding pocket [chemical binding]; other site
546414005130	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
546414005131	Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cl00217
546414005132	Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565
546414005133	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
546414005134	active site
546414005135	phosphorylation site [posttranslational modification]
546414005136	intermolecular recognition site; other site
546414005137	dimerization interface [polypeptide binding]; other site
546414005138	IclR helix-turn-helix domain; Region: HTH_IclR; cl17605
546414005139	Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290
546414005140	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
546414005141	ATP binding site [chemical binding]; other site
546414005142	Mg2+ binding site [ion binding]; other site
546414005143	G-X-G motif; other site
546414005144	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181
546414005145	Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331
546414005146	Tripartite tricarboxylate transporter TctA family; Region: TctA; cl00772
546414005147	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
546414005148	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
546414005149	active site
546414005150	phosphorylation site [posttranslational modification]
546414005151	intermolecular recognition site; other site
546414005152	dimerization interface [polypeptide binding]; other site
546414005153	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
546414005154	DNA binding residues [nucleotide binding]
546414005155	dimerization interface [polypeptide binding]; other site
546414005156	Domain of unknown function (DUF4098); Region: DUF4098; pfam13345
546414005157	Putative sensor; Region: Sensor; pfam13796
546414005158	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
546414005159	Histidine kinase; Region: HisKA_3; pfam07730
546414005160	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
546414005161	ATP binding site [chemical binding]; other site
546414005162	Mg2+ binding site [ion binding]; other site
546414005163	G-X-G motif; other site
546414005164	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
546414005165	Signal peptidase I [Intracellular trafficking and secretion]; Region: LepB; COG0681
546414005166	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
546414005167	Catalytic site [active]
546414005168	Predicted transcriptional regulators [Transcription]; Region: COG1695
546414005169	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
546414005170	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883
546414005171	nudix motif; other site
546414005172	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
546414005173	active site
546414005174	Ribosome-binding factor A [Translation, ribosomal structure and biogenesis]; Region: RbfA; COG0858
546414005175	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
546414005176	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
546414005177	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
546414005178	Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992
546414005179	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
546414005180	metal ion-dependent adhesion site (MIDAS); other site
546414005181	DNA gyrase subunit B; Validated; Region: gyrB; PRK05644
546414005182	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
546414005183	ATP binding site [chemical binding]; other site
546414005184	Mg2+ binding site [ion binding]; other site
546414005185	G-X-G motif; other site
546414005186	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
546414005187	anchoring element; other site
546414005188	dimer interface [polypeptide binding]; other site
546414005189	ATP binding site [chemical binding]; other site
546414005190	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
546414005191	active site
546414005192	putative metal-binding site [ion binding]; other site
546414005193	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
546414005194	haloalkane dehalogenase; Provisional; Region: PRK03592
546414005195	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
546414005196	catalytic site [active]
546414005197	Plastocyanin [Energy production and conversion]; Region: PetE; COG3794
546414005198	Cupredoxin-like domain; Region: Cupredoxin_1; cl17234
546414005199	Putative cyclase; Region: Cyclase; cl00814
546414005200	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
546414005201	active site
546414005202	PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH  (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme.  DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488
546414005203	aromatic arch; other site
546414005204	DCoH dimer interaction site [polypeptide binding]; other site
546414005205	DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site
546414005206	DCoH tetramer interaction site [polypeptide binding]; other site
546414005207	substrate binding site [chemical binding]; other site
546414005208	DNA mismatch repair protein MutS; Provisional; Region: PRK05399
546414005209	MutS domain I; Region: MutS_I; pfam01624
546414005210	MutS domain II; Region: MutS_II; pfam05188
546414005211	MutS domain III; Region: MutS_III; pfam05192
546414005212	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
546414005213	Walker A/P-loop; other site
546414005214	ATP binding site [chemical binding]; other site
546414005215	Q-loop/lid; other site
546414005216	ABC transporter signature motif; other site
546414005217	Walker B; other site
546414005218	D-loop; other site
546414005219	H-loop/switch region; other site
546414005220	Predicted membrane protein [Function unknown]; Region: COG4325
546414005221	Predicted membrane protein (DUF2254); Region: DUF2254; pfam10011
546414005222	Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809
546414005223	FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070
546414005224	active site
546414005225	substrate binding site [chemical binding]; other site
546414005226	FMN binding site [chemical binding]; other site
546414005227	putative catalytic residues [active]
546414005228	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
546414005229	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
546414005230	catalytic residues [active]
546414005231	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
546414005232	FAD binding domain; Region: FAD_binding_4; pfam01565
546414005233	DNA mismatch repair protein MutL; Region: mutl; TIGR00585
546414005234	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
546414005235	ATP binding site [chemical binding]; other site
546414005236	Mg2+ binding site [ion binding]; other site
546414005237	G-X-G motif; other site
546414005238	MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782
546414005239	ATP binding site [chemical binding]; other site
546414005240	MutL C terminal dimerisation domain; Region: MutL_C; smart00853
546414005241	DNA-binding transcriptional activator of the SARP family [Signal transduction mechanisms]; Region: DnrI; COG3629
546414005242	Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862
546414005243	DNA binding site [nucleotide binding]
546414005244	AAA ATPase domain; Region: AAA_16; pfam13191
546414005245	Thiol-activated cytolysin; Region: Thiol_cytolysin; pfam01289
546414005246	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
546414005247	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
546414005248	HIGH motif; other site
546414005249	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
546414005250	active site
546414005251	KMSKS motif; other site
546414005252	methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071
546414005253	B12 binding site [chemical binding]; other site
546414005254	cobalt ligand [ion binding]; other site
546414005255	Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055
546414005256	Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the...; Region: P_permease; cd01116
546414005257	transmembrane helices; other site
546414005258	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
546414005259	membrane protein; Provisional; Region: PRK14402
546414005260	aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874
546414005261	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
546414005262	Rhomboid family; Region: Rhomboid; cl11446
546414005263	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
546414005264	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
546414005265	metal binding site [ion binding]; metal-binding site
546414005266	active site
546414005267	I-site; other site
546414005268	Glyoxalase-like domain; Region: Glyoxalase_3; pfam13468
546414005269	Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593
546414005270	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
546414005271	hydroxyglutarate oxidase; Provisional; Region: PRK11728
546414005272	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
546414005273	putative substrate translocation pore; other site
546414005274	Transcriptional regulators [Transcription]; Region: MarR; COG1846
546414005275	MarR family; Region: MarR_2; pfam12802
546414005276	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
546414005277	nudix motif; other site
546414005278	cyanate transporter; Region: CynX; TIGR00896
546414005279	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
546414005280	putative substrate translocation pore; other site
546414005281	ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143
546414005282	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
546414005283	Catalytic domain, repeat 1, of phospholipase D from Streptomyces Sp. Strain PMF and similar proteins; Region: PLDc_PMFPLD_like_1; cd09108
546414005284	domain interface [polypeptide binding]; other site
546414005285	Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502
546414005286	putative active site [active]
546414005287	catalytic site [active]
546414005288	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
546414005289	putative active site [active]
546414005290	catalytic site [active]
546414005291	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
546414005292	ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839
546414005293	ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259
546414005294	Walker A/P-loop; other site
546414005295	ATP binding site [chemical binding]; other site
546414005296	Q-loop/lid; other site
546414005297	ABC transporter signature motif; other site
546414005298	Walker B; other site
546414005299	D-loop; other site
546414005300	H-loop/switch region; other site
546414005301	Curli production assembly/transport component CsgG; Region: CsgG; cl17434
546414005302	Thiamine pyrophosphokinase [Coenzyme metabolism]; Region: THI80; COG1564
546414005303	Thiamine pyrophosphokinase; Region: TPK; cd07995
546414005304	active site
546414005305	dimerization interface [polypeptide binding]; other site
546414005306	thiamine binding site [chemical binding]; other site
546414005307	glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062
546414005308	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
546414005309	inhibitor-cofactor binding pocket; inhibition site
546414005310	pyridoxal 5'-phosphate binding site [chemical binding]; other site
546414005311	catalytic residue [active]
546414005312	Predicted CoA-binding protein [General function prediction only]; Region: COG1832
546414005313	Homoserine dehydrogenase [Amino acid transport and metabolism]; Region: ThrA; COG0460
546414005314	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
546414005315	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
546414005316	peptide chain release factor 1; Validated; Region: prfA; PRK00591
546414005317	PCRF domain; Region: PCRF; pfam03462
546414005318	RF-1 domain; Region: RF-1; pfam00472
546414005319	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883
546414005320	nudix motif; other site
546414005321	NADPH_oxidase. Nitroreductase family containing NADH oxidase and other, uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and nitroimidazoles; Region: NADH_oxidase; cd03370
546414005322	dimer interface [polypeptide binding]; other site
546414005323	FMN binding site [chemical binding]; other site
546414005324	Predicted transcriptional regulators [Transcription]; Region: COG1733
546414005325	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
546414005326	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
546414005327	homotrimer interaction site [polypeptide binding]; other site
546414005328	putative active site [active]
546414005329	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881
546414005330	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates...; Region: IMPCH; cd01421
546414005331	purine monophosphate binding site [chemical binding]; other site
546414005332	dimer interface [polypeptide binding]; other site
546414005333	putative catalytic residues [active]
546414005334	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798
546414005335	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362
546414005336	5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme metabolism]; Region: FolD; COG0190
546414005337	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
546414005338	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
546414005339	homodimer interface [polypeptide binding]; other site
546414005340	NADP binding site [chemical binding]; other site
546414005341	substrate binding site [chemical binding]; other site
546414005342	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
546414005343	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
546414005344	Homoserine acetyltransferase [Amino acid transport and metabolism]; Region: MET2; COG2021
546414005345	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
546414005346	OAH/OAS sulfhydrylase; Region: OAH_OAS_sulfhy; TIGR01326
546414005347	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
546414005348	homodimer interface [polypeptide binding]; other site
546414005349	substrate-cofactor binding pocket; other site
546414005350	pyridoxal 5'-phosphate binding site [chemical binding]; other site
546414005351	catalytic residue [active]
546414005352	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
546414005353	metal binding site 2 [ion binding]; metal-binding site
546414005354	putative DNA binding helix; other site
546414005355	metal binding site 1 [ion binding]; metal-binding site
546414005356	dimer interface [polypeptide binding]; other site
546414005357	structural Zn2+ binding site [ion binding]; other site
546414005358	Protein of unknown function (DUF1469); Region: DUF1469; pfam07332
546414005359	succinic semialdehyde dehydrogenase; Region: PLN02278
546414005360	Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103
546414005361	tetramerization interface [polypeptide binding]; other site
546414005362	NAD(P) binding site [chemical binding]; other site
546414005363	catalytic residues [active]
546414005364	Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
546414005365	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
546414005366	peroxiredoxin, OsmC subfamily; Region: osmo_induc_OsmC; TIGR03562
546414005367	acylphosphatase; Provisional; Region: PRK14433
546414005368	Family of unknown function (DUF490); Region: DUF490; pfam04357
546414005369	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
546414005370	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
546414005371	Walker A/P-loop; other site
546414005372	ATP binding site [chemical binding]; other site
546414005373	Q-loop/lid; other site
546414005374	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
546414005375	ABC transporter signature motif; other site
546414005376	Walker B; other site
546414005377	D-loop; other site
546414005378	ABC transporter; Region: ABC_tran_2; pfam12848
546414005379	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
546414005380	Cytochrome c; Region: Cytochrom_C; pfam00034
546414005381	Predicted sulfurtransferase [General function prediction only]; Region: COG1054
546414005382	Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518
546414005383	active site residue [active]
546414005384	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
546414005385	catalytic core [active]
546414005386	ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279
546414005387	AAA domain; Region: AAA_23; pfam13476
546414005388	Walker A/P-loop; other site
546414005389	ATP binding site [chemical binding]; other site
546414005390	Q-loop/lid; other site
546414005391	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419
546414005392	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
546414005393	ABC transporter signature motif; other site
546414005394	Walker B; other site
546414005395	D-loop; other site
546414005396	H-loop/switch region; other site
546414005397	DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420
546414005398	Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840
546414005399	active site
546414005400	metal binding site [ion binding]; metal-binding site
546414005401	DNA binding site [nucleotide binding]
546414005402	Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320
546414005403	phosphonoacetate hydrolase; Region: hydr_PhnA; TIGR02335
546414005404	Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663
546414005405	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
546414005406	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
546414005407	helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448
546414005408	AAA domain; Region: AAA_30; pfam13604
546414005409	Family description; Region: UvrD_C_2; pfam13538
546414005410	Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404
546414005411	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
546414005412	active site
546414005413	catalytic residues [active]
546414005414	Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151
546414005415	CTP synthetase; Validated; Region: pyrG; PRK05380
546414005416	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
546414005417	Catalytic site [active]
546414005418	active site
546414005419	UTP binding site [chemical binding]; other site
546414005420	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
546414005421	active site
546414005422	putative oxyanion hole; other site
546414005423	catalytic triad [active]
546414005424	formamidopyrimidine-DNA glycosylase; Provisional; Region: PRK14811
546414005425	N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966
546414005426	DNA binding site [nucleotide binding]
546414005427	catalytic residue [active]
546414005428	H2TH interface [polypeptide binding]; other site
546414005429	putative catalytic residues [active]
546414005430	turnover-facilitating residue; other site
546414005431	intercalation triad [nucleotide binding]; other site
546414005432	8OG recognition residue [nucleotide binding]; other site
546414005433	putative reading head residues; other site
546414005434	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
546414005435	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
546414005436	Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I:  Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501
546414005437	putative substrate binding pocket [chemical binding]; other site
546414005438	AC domain interface; other site
546414005439	catalytic triad [active]
546414005440	AB domain interface; other site
546414005441	interchain disulfide; other site
546414005442	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
546414005443	Protein of unknown function DUF58; Region: DUF58; pfam01882
546414005444	Domain of unknown function (DUF3488); Region: DUF3488; pfam11992
546414005445	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
546414005446	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
546414005447	MoxR-like ATPases [General function prediction only]; Region: COG0714
546414005448	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
546414005449	Walker A motif; other site
546414005450	ATP binding site [chemical binding]; other site
546414005451	Walker B motif; other site
546414005452	arginine finger; other site
546414005453	Predicted integral membrane protein [Function unknown]; Region: COG5652
546414005454	Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249
546414005455	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
546414005456	dimer interface [polypeptide binding]; other site
546414005457	substrate binding site [chemical binding]; other site
546414005458	metal binding site [ion binding]; metal-binding site
546414005459	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
546414005460	active site 2 [active]
546414005461	active site 1 [active]
546414005462	Protein of unknown function (DUF402); Region: DUF402; cl00979
546414005463	Protein of unknown function (DUF402); Region: DUF402; cl00979
546414005464	Folate-dependent phosphoribosylglycinamide formyltransferase PurN [Nucleotide transport and metabolism]; Region: PurN; COG0299
546414005465	Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645
546414005466	active site
546414005467	substrate binding site [chemical binding]; other site
546414005468	cosubstrate binding site; other site
546414005469	catalytic site [active]
546414005470	hypothetical protein; Provisional; Region: PRK08201
546414005471	Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_3; cd05680
546414005472	metal binding site [ion binding]; metal-binding site
546414005473	putative dimer interface [polypeptide binding]; other site
546414005474	Helix-Turn-Helix DNA binding domain of the HspR transcription regulator; Region: HTH_HspR; cd04766
546414005475	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
546414005476	DNA binding residues [nucleotide binding]
546414005477	putative dimer interface [polypeptide binding]; other site
546414005478	Helix-Turn-Helix DNA binding domain of the HspR transcription regulator; Region: HTH_HspR; cd04766
546414005479	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
546414005480	DNA binding residues [nucleotide binding]
546414005481	putative dimer interface [polypeptide binding]; other site
546414005482	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
546414005483	nudix motif; other site
546414005484	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
546414005485	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
546414005486	active site
546414005487	metal binding site [ion binding]; metal-binding site
546414005488	Transcriptional regulator [Transcription]; Region: LysR; COG0583
546414005489	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
546414005490	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
546414005491	dimerization interface [polypeptide binding]; other site
546414005492	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
546414005493	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
546414005494	active site
546414005495	HIGH motif; other site
546414005496	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
546414005497	KMSKS motif; other site
546414005498	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
546414005499	tRNA binding surface [nucleotide binding]; other site
546414005500	anticodon binding site; other site
546414005501	Uncharacterized protein/domain associated with GTPases [Function unknown]; Region: COG3597
546414005502	glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207
546414005503	menaquinone biosynthesis protein, SCO4550 family; Region: mena_SCO4550; TIGR03699
546414005504	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
546414005505	FeS/SAM binding site; other site
546414005506	Predicted 6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; Region: Gnd; COG1023
546414005507	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
546414005508	glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722
546414005509	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
546414005510	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
546414005511	Glucose-6-phosphate dehydrogenase subunit; Region: OpcA_G6PD_assem; cl01359
546414005512	Isochorismatase family; Region: Isochorismatase; pfam00857
546414005513	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220
546414005514	catalytic triad [active]
546414005515	conserved cis-peptide bond; other site
546414005516	homomethionine N-hydroxylase; Region: PLN03018
546414005517	Uncharacterized Fe-S protein [Energy production and conversion]; Region: COG1600
546414005518	Domain of unknown function (DUF1730); Region: DUF1730; pfam08331
546414005519	4Fe-4S binding domain; Region: Fer4_6; pfam12837
546414005520	HEAT repeats; Region: HEAT_2; pfam13646
546414005521	Glutamine cyclotransferase [Posttranslational modification, protein turnover, chaperones]; Region: COG3823
546414005522	thymidylate kinase; Validated; Region: tmk; PRK00698
546414005523	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
546414005524	TMP-binding site; other site
546414005525	ATP-binding site [chemical binding]; other site
546414005526	Uncharacterized conserved protein [Function unknown]; Region: COG0327
546414005527	NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784
546414005528	NMT1-like family; Region: NMT1_2; pfam13379
546414005529	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
546414005530	substrate binding pocket [chemical binding]; other site
546414005531	membrane-bound complex binding site; other site
546414005532	hinge residues; other site
546414005533	glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100
546414005534	N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856
546414005535	Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326
546414005536	active site
546414005537	catalytic site [active]
546414005538	Maltooligosyl trehalose synthase [Carbohydrate transport and metabolism]; Region: TreY; COG3280
546414005539	Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893
546414005540	Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893
546414005541	active site
546414005542	catalytic site [active]
546414005543	Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336
546414005544	Protein of unknown function DUF72; Region: DUF72; pfam01904
546414005545	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
546414005546	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
546414005547	active site
546414005548	catalytic tetrad [active]
546414005549	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
546414005550	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
546414005551	motif II; other site
546414005552	Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432
546414005553	Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670
546414005554	Calcineurin-like phosphoesterase superfamily domain; Region: Metallophos_2; pfam12850
546414005555	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
546414005556	active site
546414005557	metal binding site [ion binding]; metal-binding site
546414005558	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
546414005559	trimer interface [polypeptide binding]; other site
546414005560	active site
546414005561	putative acyltransferase; Provisional; Region: PRK05790
546414005562	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
546414005563	dimer interface [polypeptide binding]; other site
546414005564	active site
546414005565	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
546414005566	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
546414005567	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
546414005568	Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528
546414005569	[2Fe-2S] cluster binding site [ion binding]; other site
546414005570	adenylosuccinate lyase; Provisional; Region: PRK07492
546414005571	Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360
546414005572	tetramer interface [polypeptide binding]; other site
546414005573	active site
546414005574	IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639
546414005575	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
546414005576	active site
546414005577	dimerization interface [polypeptide binding]; other site
546414005578	Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123
546414005579	Histone deacetylase class IV also known as histone deacetylase 11; Region: HDAC_classIV; cd09993
546414005580	putative active site [active]
546414005581	Zn binding site [ion binding]; other site
546414005582	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2380
546414005583	HerA helicase [Replication, recombination, and repair]; Region: COG0433
546414005584	AAA domain; Region: AAA_18; pfam13238
546414005585	AAA domain; Region: AAA_17; pfam13207
546414005586	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
546414005587	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
546414005588	RNA binding surface [nucleotide binding]; other site
546414005589	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
546414005590	active site
546414005591	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
546414005592	DEAD-like helicases superfamily; Region: DEXDc; smart00487
546414005593	ATP binding site [chemical binding]; other site
546414005594	Mg++ binding site [ion binding]; other site
546414005595	motif III; other site
546414005596	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
546414005597	nucleotide binding region [chemical binding]; other site
546414005598	ATP-binding site [chemical binding]; other site
546414005599	RNA-binding GUCT-like domain found in Thermus thermophilus heat resistant RNA-dependent ATPase (Hera) and similar proteins; Region: GUCT_Hera; cd12938
546414005600	acetolactate synthase 2 catalytic subunit; Reviewed; Region: PRK08978
546414005601	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
546414005602	PYR/PP interface [polypeptide binding]; other site
546414005603	dimer interface [polypeptide binding]; other site
546414005604	TPP binding site [chemical binding]; other site
546414005605	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
546414005606	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
546414005607	TPP-binding site [chemical binding]; other site
546414005608	dimer interface [polypeptide binding]; other site
546414005609	acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895
546414005610	N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878
546414005611	putative valine binding site [chemical binding]; other site
546414005612	dimer interface [polypeptide binding]; other site
546414005613	Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369
546414005614	ketol-acid reductoisomerase; Provisional; Region: PRK05479
546414005615	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991
546414005616	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
546414005617	Transposase; Region: HTH_Tnp_1; pfam01527
546414005618	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
546414005619	putative transposase OrfB; Reviewed; Region: PHA02517
546414005620	HTH-like domain; Region: HTH_21; pfam13276
546414005621	Integrase core domain; Region: rve; pfam00665
546414005622	Integrase core domain; Region: rve_3; pfam13683
546414005623	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
546414005624	TPR motif; other site
546414005625	binding surface
546414005626	Tetratricopeptide repeat; Region: TPR_12; pfam13424
546414005627	Tetratricopeptide repeat; Region: TPR_12; pfam13424
546414005628	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
546414005629	binding surface
546414005630	TPR motif; other site
546414005631	Tetratricopeptide repeat; Region: TPR_12; pfam13424
546414005632	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
546414005633	binding surface
546414005634	TPR motif; other site
546414005635	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
546414005636	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
546414005637	metal binding site [ion binding]; metal-binding site
546414005638	active site
546414005639	I-site; other site
546414005640	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
546414005641	2-isopropylmalate synthase; Validated; Region: PRK00915
546414005642	2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940
546414005643	active site
546414005644	catalytic residues [active]
546414005645	metal binding site [ion binding]; metal-binding site
546414005646	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502
546414005647	Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329
546414005648	Uncharacterized vancomycin resistance protein [Defense mechanisms]; Region: COG2720
546414005649	VanW like protein; Region: VanW; pfam04294
546414005650	acetylornithine aminotransferase; Provisional; Region: PRK02627
546414005651	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
546414005652	inhibitor-cofactor binding pocket; inhibition site
546414005653	pyridoxal 5'-phosphate binding site [chemical binding]; other site
546414005654	catalytic residue [active]
546414005655	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
546414005656	Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754
546414005657	Ion transport protein; Region: Ion_trans; pfam00520
546414005658	Ion channel; Region: Ion_trans_2; pfam07885
546414005659	Cobalamin adenosyltransferase; Region: Cob_adeno_trans; cl00920
546414005660	4-alpha-glucanotransferase; Provisional; Region: PRK14508
546414005661	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
546414005662	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
546414005663	active site
546414005664	metal binding site [ion binding]; metal-binding site
546414005665	Rrf2 family protein; Region: rrf2_super; TIGR00738
546414005666	Transcriptional regulator; Region: Rrf2; pfam02082
546414005667	Uncharacterized conserved protein [Function unknown]; Region: COG3342
546414005668	Family of unknown function (DUF1028); Region: DUF1028; pfam06267
546414005669	Putative peptidoglycan binding domain; Region: PG_binding_2; pfam08823
546414005670	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725
546414005671	active site
546414005672	dimer interface [polypeptide binding]; other site
546414005673	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
546414005674	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
546414005675	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
546414005676	Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011
546414005677	motif II; other site
546414005678	phosphoenolpyruvate synthase; Validated; Region: PRK06464
546414005679	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
546414005680	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
546414005681	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
546414005682	PEP synthetase regulatory protein; Provisional; Region: PRK05339
546414005683	glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179
546414005684	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
546414005685	active site
546414005686	dimer interface [polypeptide binding]; other site
546414005687	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
546414005688	dimer interface [polypeptide binding]; other site
546414005689	active site
546414005690	beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050
546414005691	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
546414005692	dimer interface [polypeptide binding]; other site
546414005693	active site
546414005694	Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism]; Region: COG4670
546414005695	Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788
546414005696	3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428
546414005697	Domain of unknown function (DUF897); Region: DUF897; cl01312
546414005698	ABC-type Fe3+-citrate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FecB; COG4594
546414005699	Fe3+-siderophore binding domain FhuD.  These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146
546414005700	siderophore binding site; other site
546414005701	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
546414005702	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
546414005703	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
546414005704	30S subunit binding site; other site
546414005705	butyrate kinase; Provisional; Region: PRK03011
546414005706	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
546414005707	S-adenosylmethionine binding site [chemical binding]; other site
546414005708	tRNA threonylcarbamoyl adenosine modification protein YgjD; Region: T6A_YgjD; TIGR03723
546414005709	Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884
546414005710	preprotein translocase subunit SecA; Reviewed; Region: PRK12904
546414005711	SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958
546414005712	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351
546414005713	nucleotide binding region [chemical binding]; other site
546414005714	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
546414005715	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
546414005716	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
546414005717	catalytic residue [active]
546414005718	Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092
546414005719	Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572
546414005720	putative RNA binding site [nucleotide binding]; other site
546414005721	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
546414005722	S-adenosylmethionine binding site [chemical binding]; other site
546414005723	acetyl-CoA acetyltransferase; Provisional; Region: PRK07661
546414005724	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
546414005725	dimer interface [polypeptide binding]; other site
546414005726	active site
546414005727	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
546414005728	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
546414005729	3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250
546414005730	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
546414005731	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
546414005732	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
546414005733	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
546414005734	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
546414005735	substrate binding site [chemical binding]; other site
546414005736	oxyanion hole (OAH) forming residues; other site
546414005737	trimer interface [polypeptide binding]; other site
546414005738	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_8; cd07817
546414005739	putative hydrophobic ligand binding site [chemical binding]; other site
546414005740	Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283
546414005741	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
546414005742	NAD binding site [chemical binding]; other site
546414005743	catalytic Zn binding site [ion binding]; other site
546414005744	structural Zn binding site [ion binding]; other site
546414005745	Domain of unknown function (DUF4384); Region: DUF4384; pfam14326
546414005746	Predicted nuclease of restriction endonuclease-like fold [General function prediction only]; Region: COG3372
546414005747	Protein of unknown function (DUF790); Region: DUF790; pfam05626
546414005748	DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061
546414005749	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
546414005750	ATP binding site [chemical binding]; other site
546414005751	putative Mg++ binding site [ion binding]; other site
546414005752	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
546414005753	nucleotide binding region [chemical binding]; other site
546414005754	ATP-binding site [chemical binding]; other site
546414005755	glycogen synthase; Provisional; Region: glgA; PRK00654
546414005756	This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791
546414005757	ADP-binding pocket [chemical binding]; other site
546414005758	homodimer interface [polypeptide binding]; other site
546414005759	3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427
546414005760	Uncharacterized protein family (UPF0227); Region: UPF0227; cl14886
546414005761	putative hydrolase; Provisional; Region: PRK11460
546414005762	Predicted esterase [General function prediction only]; Region: COG0400
546414005763	Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514
546414005764	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255
546414005765	putative metal binding site [ion binding]; other site
546414005766	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
546414005767	active site
546414005768	DoxX; Region: DoxX; pfam07681
546414005769	MarR family; Region: MarR; pfam01047
546414005770	rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565
546414005771	SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307
546414005772	GAF domain; Region: GAF_2; pfam13185
546414005773	GAF domain; Region: GAF_3; pfam13492
546414005774	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
546414005775	Histidine kinase; Region: HisKA_3; pfam07730
546414005776	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
546414005777	ATP binding site [chemical binding]; other site
546414005778	Mg2+ binding site [ion binding]; other site
546414005779	G-X-G motif; other site
546414005780	Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922
546414005781	Peptidase S8 family domain in ProteinaseK-like proteins; Region: Peptidases_S8_PCSK9_ProteinaseK_like; cd04077
546414005782	calcium binding site 2 [ion binding]; other site
546414005783	Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404
546414005784	active site
546414005785	catalytic triad [active]
546414005786	calcium binding site 1 [ion binding]; other site
546414005787	CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461
546414005788	Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363
546414005789	M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656
546414005790	oligomer interface [polypeptide binding]; other site
546414005791	active site
546414005792	metal binding site [ion binding]; metal-binding site
546414005793	tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815
546414005794	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
546414005795	FMN binding site [chemical binding]; other site
546414005796	active site
546414005797	catalytic residues [active]
546414005798	substrate binding site [chemical binding]; other site
546414005799	Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973
546414005800	Family description; Region: UvrD_C_2; pfam13538
546414005801	glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK05293
546414005802	ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508
546414005803	ligand binding site; other site
546414005804	oligomer interface; other site
546414005805	Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651
546414005806	dimer interface [polypeptide binding]; other site
546414005807	N-terminal domain interface [polypeptide binding]; other site
546414005808	sulfate 1 binding site; other site
546414005809	glycyl-tRNA synthetase; Provisional; Region: PRK04173
546414005810	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
546414005811	motif 1; other site
546414005812	Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774
546414005813	active site
546414005814	motif 2; other site
546414005815	motif 3; other site
546414005816	HGTP anticodon binding domain, as found at the C-terminus of histidyl, glycyl, threonyl and prolyl tRNA synthetases, which are classified as a group of class II aminoacyl-tRNA synthetases (aaRS). In aaRSs, the anticodon binding domain is responsible for...; Region: HGTP_anticodon; cl00266
546414005817	anticodon binding site; other site
546414005818	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
546414005819	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_9; cd07245
546414005820	dimer interface [polypeptide binding]; other site
546414005821	putative metal binding site [ion binding]; other site
546414005822	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
546414005823	Lipase.  Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883
546414005824	nucleophilic elbow; other site
546414005825	catalytic triad; other site
546414005826	G:T/U mismatch specific DNA glcosylase (MUG); Region: UDG_F2_MUG; cd10028
546414005827	active site
546414005828	SUMO-1 interface [polypeptide binding]; other site
546414005829	Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041
546414005830	bacterial and archael members of the sulfite oxidase (SO) family of molybdopterin binding domains. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and...; Region: arch_bact_SO_family_Moco; cd02109
546414005831	Moco binding site; other site
546414005832	metal coordination site [ion binding]; other site
546414005833	Domain of unknown function (DUF4032); Region: DUF4032; pfam13224
546414005834	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
546414005835	interface (dimer of trimers) [polypeptide binding]; other site
546414005836	Substrate-binding/catalytic site; other site
546414005837	Zn-binding sites [ion binding]; other site
546414005838	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302
546414005839	DAK2 domain fusion protein YloV; Region: YloV; TIGR03599
546414005840	DAK2 domain; Region: Dak2; pfam02734
546414005841	UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Region: murF; TIGR01143
546414005842	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
546414005843	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
546414005844	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
546414005845	type IV pilus assembly protein PilM; Region: pilM; TIGR01175
546414005846	Cell division protein FtsA; Region: FtsA; pfam14450
546414005847	Pilus assembly protein, PilO; Region: PilO; cl01234
546414005848	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
546414005849	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
546414005850	pilus (MSHA type) biogenesis protein MshL; Region: pilus_MshL; TIGR02519
546414005851	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
546414005852	Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082
546414005853	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
546414005854	Tetramer interface [polypeptide binding]; other site
546414005855	active site
546414005856	FMN-binding site [chemical binding]; other site
546414005857	shikimate kinase; Provisional; Region: PRK13948
546414005858	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
546414005859	ADP binding site [chemical binding]; other site
546414005860	magnesium binding site [ion binding]; other site
546414005861	putative shikimate binding site; other site
546414005862	Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195
546414005863	active site
546414005864	dimer interface [polypeptide binding]; other site
546414005865	metal binding site [ion binding]; metal-binding site
546414005866	Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466
546414005867	Dehydroquinase class II; Region: DHquinase_II; pfam01220
546414005868	active site
546414005869	trimer interface [polypeptide binding]; other site
546414005870	dimer interface [polypeptide binding]; other site
546414005871	deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01286
546414005872	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
546414005873	Zn2+ binding site [ion binding]; other site
546414005874	Mg2+ binding site [ion binding]; other site
546414005875	Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286
546414005876	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
546414005877	dimer interface [polypeptide binding]; other site
546414005878	ADP-ribose binding site [chemical binding]; other site
546414005879	active site
546414005880	nudix motif; other site
546414005881	metal binding site [ion binding]; metal-binding site
546414005882	bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627
546414005883	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
546414005884	active site
546414005885	Riboflavin kinase; Region: Flavokinase; pfam01687
546414005886	Predicted periplasmic solute-binding protein [General function prediction only]; Region: COG2107
546414005887	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
546414005888	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
546414005889	Walker A/P-loop; other site
546414005890	ATP binding site [chemical binding]; other site
546414005891	Q-loop/lid; other site
546414005892	ABC transporter signature motif; other site
546414005893	Walker B; other site
546414005894	D-loop; other site
546414005895	H-loop/switch region; other site
546414005896	ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679
546414005897	GTPase SAR1 and related small G proteins [General function prediction only]; Region: COG1100
546414005898	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882
546414005899	G1 box; other site
546414005900	GTP/Mg2+ binding site [chemical binding]; other site
546414005901	G2 box; other site
546414005902	Switch I region; other site
546414005903	G3 box; other site
546414005904	Switch II region; other site
546414005905	G4 box; other site
546414005906	G5 box; other site
546414005907	Roadblock/LC7 domain; Region: Robl_LC7; pfam03259
546414005908	Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992
546414005909	DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847
546414005910	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
546414005911	active site
546414005912	catalytic site [active]
546414005913	substrate binding site [chemical binding]; other site
546414005914	UV-endonuclease UvdE; Region: UvdE; cl10036
546414005915	Uncharacterized protein conserved in bacteria (DUF2256); Region: DUF2256; pfam10013
546414005916	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
546414005917	active site
546414005918	Protein of unknown function (DUF817); Region: DUF817; cl01520
546414005919	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
546414005920	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
546414005921	catalytic residues [active]
546414005922	catalytic nucleophile [active]
546414005923	Restriction endonuclease [Defense mechanisms]; Region: Mrr; COG1715
546414005924	Mrr N-terminal domain; Region: Mrr_N; pfam14338
546414005925	Restriction endonuclease; Region: Mrr_cat; pfam04471
546414005926	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
546414005927	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
546414005928	catalytic residues [active]
546414005929	catalytic nucleophile [active]
546414005930	Recombinase; Region: Recombinase; pfam07508
546414005931	Arginine decarboxylase (spermidine biosynthesis) [Amino acid transport and metabolism]; Region: SpeA; COG1166
546414005932	Uncharacterized conserved protein [Function unknown]; Region: COG1801
546414005933	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
546414005934	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
546414005935	active site
546414005936	phosphorylation site [posttranslational modification]
546414005937	intermolecular recognition site; other site
546414005938	dimerization interface [polypeptide binding]; other site
546414005939	The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731
546414005940	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
546414005941	substrate binding site [chemical binding]; other site
546414005942	glutamase interaction surface [polypeptide binding]; other site
546414005943	bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759
546414005944	phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051
546414005945	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534
546414005946	metal binding site [ion binding]; metal-binding site
546414005947	Domain of unknown function (DUF4394); Region: DUF4394; pfam14339
546414005948	Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402
546414005949	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
546414005950	active site
546414005951	metal binding site [ion binding]; metal-binding site
546414005952	hexamer interface [polypeptide binding]; other site
546414005953	5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212; cl00360
546414005954	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
546414005955	Catalytic domain of Protein Kinases; Region: PKc; cd00180
546414005956	active site
546414005957	ATP binding site [chemical binding]; other site
546414005958	substrate binding site [chemical binding]; other site
546414005959	activation loop (A-loop); other site
546414005960	PQQ-like domain; Region: PQQ_2; pfam13360
546414005961	PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493
546414005962	Trp docking motif [polypeptide binding]; other site
546414005963	active site
546414005964	twin arginine translocase protein A; Provisional; Region: tatA; PRK14861
546414005965	Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606
546414005966	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
546414005967	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078
546414005968	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335
546414005969	acetyl-lysine deacetylase; Provisional; Region: PRK04443
546414005970	M20 Peptidase acetylornithine deacetylase/acetyl-lysine deacetylase; Region: M20_ArgE_LysK; cd05653
546414005971	metal binding site [ion binding]; metal-binding site
546414005972	putative dimer interface [polypeptide binding]; other site
546414005973	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
546414005974	transmembrane helices; other site
546414005975	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
546414005976	TrkA-C domain; Region: TrkA_C; pfam02080
546414005977	TrkA-C domain; Region: TrkA_C; pfam02080
546414005978	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
546414005979	H+ Antiporter protein; Region: 2A0121; TIGR00900
546414005980	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
546414005981	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
546414005982	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
546414005983	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
546414005984	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
546414005985	NlpC/P60 family; Region: NLPC_P60; pfam00877
546414005986	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
546414005987	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
546414005988	hinge; other site
546414005989	active site
546414005990	Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686
546414005991	Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305
546414005992	hexamer interface [polypeptide binding]; other site
546414005993	ligand binding site [chemical binding]; other site
546414005994	putative active site [active]
546414005995	NAD(P) binding site [chemical binding]; other site
546414005996	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
546414005997	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
546414005998	putative DNA binding site [nucleotide binding]; other site
546414005999	putative Zn2+ binding site [ion binding]; other site
546414006000	AsnC family; Region: AsnC_trans_reg; pfam01037
546414006001	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317
546414006002	active site
546414006003	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
546414006004	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
546414006005	metal binding site [ion binding]; metal-binding site
546414006006	active site
546414006007	I-site; other site
546414006008	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
546414006009	CHASE3 domain; Region: CHASE3; cl05000
546414006010	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
546414006011	dimerization interface [polypeptide binding]; other site
546414006012	GAF domain; Region: GAF_3; pfam13492
546414006013	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
546414006014	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
546414006015	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
546414006016	metal binding site [ion binding]; metal-binding site
546414006017	active site
546414006018	I-site; other site
546414006019	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
546414006020	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
546414006021	active site
546414006022	phosphorylation site [posttranslational modification]
546414006023	intermolecular recognition site; other site
546414006024	dimerization interface [polypeptide binding]; other site
546414006025	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
546414006026	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
546414006027	putative dimer interface [polypeptide binding]; other site
546414006028	Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065
546414006029	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
546414006030	active site
546414006031	aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856
546414006032	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
546414006033	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
546414006034	dihydroorotase; Validated; Region: pyrC; PRK09357
546414006035	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
546414006036	Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317
546414006037	active site
546414006038	Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223
546414006039	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
546414006040	putative substrate translocation pore; other site
546414006041	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754
546414006042	formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591
546414006043	[4Fe-4S] binding site [ion binding]; other site
546414006044	molybdopterin cofactor binding site; other site
546414006045	This CD includes formate dehydrogenases (Fdh) H and N; nitrate reductases, Nap and Nas; and other related proteins. Formate dehydrogenase H is a component of the anaerobic formate hydrogen lyase complex  and catalyzes the reversible oxidation of formate...; Region: MopB_CT_Fdh-Nap-like; cd00508
546414006046	molybdopterin cofactor binding site; other site
546414006047	nitrite reductase subunit NirD; Provisional; Region: PRK14989
546414006048	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
546414006049	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
546414006050	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
546414006051	Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529
546414006052	uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928
546414006053	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
546414006054	active site
546414006055	dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286
546414006056	Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738
546414006057	quinone interaction residues [chemical binding]; other site
546414006058	active site
546414006059	catalytic residues [active]
546414006060	FMN binding site [chemical binding]; other site
546414006061	substrate binding site [chemical binding]; other site
546414006062	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
546414006063	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
546414006064	Sulfate transporter family; Region: Sulfate_transp; pfam00916
546414006065	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
546414006066	Transcriptional regulator; Region: Rrf2; cl17282
546414006067	Rrf2 family protein; Region: rrf2_super; TIGR00738
546414006068	Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147
546414006069	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
546414006070	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
546414006071	Glutamine amidotransferase class-I; Region: GATase; pfam00117
546414006072	glutamine binding [chemical binding]; other site
546414006073	catalytic triad [active]
546414006074	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
546414006075	homodimer interface [polypeptide binding]; other site
546414006076	substrate-cofactor binding pocket; other site
546414006077	Aminotransferase class IV; Region: Aminotran_4; pfam01063
546414006078	pyridoxal 5'-phosphate binding site [chemical binding]; other site
546414006079	catalytic residue [active]
546414006080	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
546414006081	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
546414006082	substrate binding pocket [chemical binding]; other site
546414006083	chain length determination region; other site
546414006084	substrate-Mg2+ binding site; other site
546414006085	catalytic residues [active]
546414006086	aspartate-rich region 1; other site
546414006087	active site lid residues [active]
546414006088	aspartate-rich region 2; other site
546414006089	Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334
546414006090	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
546414006091	NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076
546414006092	NAD(P) binding site [chemical binding]; other site
546414006093	Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334
546414006094	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
546414006095	NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076
546414006096	NAD(P) binding site [chemical binding]; other site
546414006097	Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557
546414006098	active site
546414006099	oligomerization interface [polypeptide binding]; other site
546414006100	metal binding site [ion binding]; metal-binding site
546414006101	Protein of unknown function (DUF420); Region: DUF420; cl00989
546414006102	Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628
546414006103	Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628
546414006104	protoheme IX farnesyltransferase; Provisional; Region: PRK04375
546414006105	UbiA prenyltransferase family; Region: UbiA; pfam01040
546414006106	cytochrome c oxidase, subunit II; Region: CoxB; TIGR02866
546414006107	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
546414006108	Cytochrome c; Region: Cytochrom_C; pfam00034
546414006109	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
546414006110	cytochrome c oxidase, subunit I; Region: CtaD_CoxA; TIGR02891
546414006111	Heme-copper oxidase subunit III.  Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386
546414006112	Subunit I/III interface [polypeptide binding]; other site
546414006113	SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968
546414006114	Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999
546414006115	Cu(I) binding site [ion binding]; other site
546414006116	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
546414006117	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
546414006118	Walker A motif; other site
546414006119	ATP binding site [chemical binding]; other site
546414006120	Walker B motif; other site
546414006121	arginine finger; other site
546414006122	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
546414006123	Predicted esterase [General function prediction only]; Region: COG0400
546414006124	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
546414006125	N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346
546414006126	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
546414006127	Zn binding site [ion binding]; other site
546414006128	C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347
546414006129	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
546414006130	Zn binding site [ion binding]; other site
546414006131	N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346
546414006132	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
546414006133	Zn binding site [ion binding]; other site
546414006134	C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347
546414006135	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
546414006136	Zn binding site [ion binding]; other site
546414006137	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
546414006138	MarR family; Region: MarR; pfam01047
546414006139	Arsenate Reductase (ArsC) family; composed of TRX-fold arsenic reductases and similar proteins including the transcriptional regulator, Spx. ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], using reducing equivalents derived from...; Region: ArsC_family; cd02977
546414006140	ArsC family; Region: ArsC; pfam03960
546414006141	catalytic residue [active]
546414006142	Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243
546414006143	The MopB_3 CD includes a group of related uncharacterized bacterial and archaeal molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members...; Region: MopB_3; cd02766
546414006144	putative [4Fe-4S] binding site [ion binding]; other site
546414006145	putative molybdopterin cofactor binding site [chemical binding]; other site
546414006146	The MopB_CT_3 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is of the...; Region: MopB_CT_3; cd02786
546414006147	putative molybdopterin cofactor binding site; other site
546414006148	Phosphotransferase enzyme family; Region: APH; pfam01636
546414006149	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
546414006150	active site
546414006151	substrate binding site [chemical binding]; other site
546414006152	ATP binding site [chemical binding]; other site
546414006153	Peptidase M36 family also known as fungalysin family; Region: M36; cd09596
546414006154	Zn binding site [ion binding]; other site
546414006155	polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824
546414006156	Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363
546414006157	RNase E interface [polypeptide binding]; other site
546414006158	trimer interface [polypeptide binding]; other site
546414006159	Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364
546414006160	RNase E interface [polypeptide binding]; other site
546414006161	trimer interface [polypeptide binding]; other site
546414006162	active site
546414006163	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
546414006164	putative nucleic acid binding region [nucleotide binding]; other site
546414006165	G-X-X-G motif; other site
546414006166	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
546414006167	RNA binding site [nucleotide binding]; other site
546414006168	domain interface; other site
546414006169	Transglycosylase; Region: Transgly; pfam00912
546414006170	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
546414006171	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
546414006172	tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696
546414006173	This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily  includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which  binds to Adenosine group.  This subfamily; Region: Alpha_ANH_like_II; cd01993
546414006174	Ligand Binding Site [chemical binding]; other site
546414006175	TIGR00269 family protein; Region: TIGR00269
546414006176	phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261
546414006177	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
546414006178	Yip1 domain; Region: Yip1; cl17815
546414006179	GTPase Era; Reviewed; Region: era; PRK00089
546414006180	E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163
546414006181	G1 box; other site
546414006182	GTP/Mg2+ binding site [chemical binding]; other site
546414006183	Switch I region; other site
546414006184	G2 box; other site
546414006185	Switch II region; other site
546414006186	G3 box; other site
546414006187	G4 box; other site
546414006188	G5 box; other site
546414006189	KH domain; Region: KH_2; pfam07650
546414006190	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
546414006191	nudix motif; other site
546414006192	metal-dependent hydrolase; Provisional; Region: PRK13291
546414006193	DinB superfamily; Region: DinB_2; pfam12867
546414006194	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain putative pyrophosphatase YpjD from Bacillus subtilis and its bacterial homologs; Region: NTP-PPase_BsYpjD; cd11531
546414006195	homodimer interface [polypeptide binding]; other site
546414006196	metal binding site [ion binding]; metal-binding site
546414006197	Domain of unknown function (DUF4384); Region: DUF4384; pfam14326
546414006198	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
546414006199	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
546414006200	Walker A motif; other site
546414006201	ATP binding site [chemical binding]; other site
546414006202	Walker B motif; other site
546414006203	arginine finger; other site
546414006204	Peptidase family M41; Region: Peptidase_M41; pfam01434
546414006205	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
546414006206	Mechanosensitive ion channel; Region: MS_channel; pfam00924
546414006207	putative phosphate acyltransferase; Provisional; Region: PRK05331
546414006208	Uncharacterized conserved protein [Function unknown]; Region: COG1432
546414006209	LabA_like proteins; Region: LabA; cd10911
546414006210	putative metal binding site [ion binding]; other site
546414006211	Domain of unknown function (DUF309); Region: DUF309; pfam03745
546414006212	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
546414006213	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
546414006214	catalytic residues [active]
546414006215	Predicted esterase of the alpha/beta hydrolase fold [General function prediction only]; Region: COG3545
546414006216	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
546414006217	50S ribosomal protein L17; Validated; Region: rplQ; PRK05591
546414006218	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
546414006219	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
546414006220	alphaNTD - beta interaction site [polypeptide binding]; other site
546414006221	alphaNTD homodimer interface [polypeptide binding]; other site
546414006222	alphaNTD - beta' interaction site [polypeptide binding]; other site
546414006223	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
546414006224	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
546414006225	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
546414006226	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
546414006227	RNA binding surface [nucleotide binding]; other site
546414006228	30S ribosomal protein S11; Validated; Region: PRK05309
546414006229	30S ribosomal protein S13; Validated; Region: rpsM; PRK05179
546414006230	30S ribosomal protein S13; Region: bact_S13; TIGR03631
546414006231	50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465
546414006232	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
546414006233	rRNA binding site [nucleotide binding]; other site
546414006234	predicted 30S ribosome binding site; other site
546414006235	VWA domain containing CoxE-like protein; Region: VWA_CoxE; pfam05762
546414006236	VWA YIEM type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: VWA_YIEM_type; cd01462
546414006237	metal ion-dependent adhesion site (MIDAS); other site
546414006238	MoxR-like ATPases [General function prediction only]; Region: COG0714
546414006239	AAA domain (dynein-related subfamily); Region: AAA_5; pfam07728
546414006240	adenylate kinase; Provisional; Region: PRK14527
546414006241	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
546414006242	AMP-binding site [chemical binding]; other site
546414006243	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
546414006244	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
546414006245	SecY translocase; Region: SecY; pfam00344
546414006246	50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592
546414006247	Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658
546414006248	23S rRNA binding site [nucleotide binding]; other site
546414006249	30S ribosomal protein S5; Validated; Region: rpsE; PRK00550
546414006250	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
546414006251	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
546414006252	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
546414006253	5S rRNA interface [nucleotide binding]; other site
546414006254	23S rRNA interface [nucleotide binding]; other site
546414006255	L5 interface [polypeptide binding]; other site
546414006256	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
546414006257	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
546414006258	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
546414006259	30S ribosomal protein S8; Validated; Region: rpsH; PRK00136
546414006260	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061
546414006261	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
546414006262	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
546414006263	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
546414006264	50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004
546414006265	KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089
546414006266	RNA binding site [nucleotide binding]; other site
546414006267	50S ribosomal protein L14; Validated; Region: rplN; PRK05483
546414006268	30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610
546414006269	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427
546414006270	23S rRNA interface [nucleotide binding]; other site
546414006271	putative translocon interaction site; other site
546414006272	signal recognition particle (SRP54) interaction site; other site
546414006273	L23 interface [polypeptide binding]; other site
546414006274	trigger factor interaction site; other site
546414006275	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
546414006276	23S rRNA interface [nucleotide binding]; other site
546414006277	5S rRNA interface [nucleotide binding]; other site
546414006278	putative antibiotic binding site [chemical binding]; other site
546414006279	L25 interface [polypeptide binding]; other site
546414006280	L27 interface [polypeptide binding]; other site
546414006281	30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310
546414006282	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
546414006283	G-X-X-G motif; other site
546414006284	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
546414006285	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
546414006286	putative translocon binding site; other site
546414006287	protein-rRNA interface [nucleotide binding]; other site
546414006288	30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357
546414006289	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
546414006290	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
546414006291	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
546414006292	50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738
546414006293	50S ribosomal protein L4; Provisional; Region: rplD; PRK05319
546414006294	50S ribosomal protein L3; Validated; Region: rplC; PRK00001
546414006295	30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596
546414006296	elongation factor Tu; Reviewed; Region: PRK00049
546414006297	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
546414006298	G1 box; other site
546414006299	GEF interaction site [polypeptide binding]; other site
546414006300	GTP/Mg2+ binding site [chemical binding]; other site
546414006301	Switch I region; other site
546414006302	G2 box; other site
546414006303	G3 box; other site
546414006304	Switch II region; other site
546414006305	G4 box; other site
546414006306	G5 box; other site
546414006307	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
546414006308	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
546414006309	Antibiotic Binding Site [chemical binding]; other site
546414006310	elongation factor G; Reviewed; Region: PRK00007
546414006311	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
546414006312	G1 box; other site
546414006313	putative GEF interaction site [polypeptide binding]; other site
546414006314	GTP/Mg2+ binding site [chemical binding]; other site
546414006315	Switch I region; other site
546414006316	G2 box; other site
546414006317	G3 box; other site
546414006318	Switch II region; other site
546414006319	G4 box; other site
546414006320	G5 box; other site
546414006321	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
546414006322	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
546414006323	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
546414006324	30S ribosomal protein S7; Validated; Region: PRK05302
546414006325	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
546414006326	S17 interaction site [polypeptide binding]; other site
546414006327	S8 interaction site; other site
546414006328	16S rRNA interaction site [nucleotide binding]; other site
546414006329	streptomycin interaction site [chemical binding]; other site
546414006330	23S rRNA interaction site [nucleotide binding]; other site
546414006331	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
546414006332	Hydrolase of X-linked nucleoside diphosphate N terminal; Region: Nudix_N; pfam12535
546414006333	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
546414006334	nudix motif; other site
546414006335	Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1),  6-pyrovoyl...; Region: TFold; cl00263
546414006336	GTP-binding protein HflX; Region: GTP_HflX; TIGR03156
546414006337	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
546414006338	HflX GTPase family; Region: HflX; cd01878
546414006339	G1 box; other site
546414006340	GTP/Mg2+ binding site [chemical binding]; other site
546414006341	Switch I region; other site
546414006342	G2 box; other site
546414006343	G3 box; other site
546414006344	Switch II region; other site
546414006345	G4 box; other site
546414006346	G5 box; other site
546414006347	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
546414006348	putative catalytic site [active]
546414006349	putative metal binding site [ion binding]; other site
546414006350	putative phosphate binding site [ion binding]; other site
546414006351	Protein of unknown function DUF45; Region: DUF45; pfam01863
546414006352	Predicted metalloprotease [General function prediction only]; Region: COG2321
546414006353	Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228
546414006354	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
546414006355	ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259
546414006356	Walker A/P-loop; other site
546414006357	ATP binding site [chemical binding]; other site
546414006358	Q-loop/lid; other site
546414006359	ABC transporter signature motif; other site
546414006360	Walker B; other site
546414006361	D-loop; other site
546414006362	H-loop/switch region; other site
546414006363	TOBE domain; Region: TOBE_2; pfam08402
546414006364	ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178
546414006365	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
546414006366	dimer interface [polypeptide binding]; other site
546414006367	conserved gate region; other site
546414006368	putative PBP binding loops; other site
546414006369	ABC-ATPase subunit interface; other site
546414006370	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
546414006371	dimer interface [polypeptide binding]; other site
546414006372	conserved gate region; other site
546414006373	ABC-ATPase subunit interface; other site
546414006374	ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143
546414006375	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
546414006376	D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966
546414006377	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
546414006378	D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478
546414006379	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
546414006380	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512
546414006381	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
546414006382	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
546414006383	dimer interface [polypeptide binding]; other site
546414006384	conserved gate region; other site
546414006385	ABC-ATPase subunit interface; other site
546414006386	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
546414006387	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
546414006388	dimer interface [polypeptide binding]; other site
546414006389	conserved gate region; other site
546414006390	putative PBP binding loops; other site
546414006391	ABC-ATPase subunit interface; other site
546414006392	Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354
546414006393	folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317
546414006394	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
546414006395	glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045
546414006396	NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213
546414006397	tRNA; other site
546414006398	putative tRNA binding site [nucleotide binding]; other site
546414006399	putative NADP binding site [chemical binding]; other site
546414006400	Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme metabolism]; Region: CysG; COG1648
546414006401	Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241
546414006402	GAF domain; Region: GAF_3; pfam13492
546414006403	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
546414006404	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
546414006405	Zn2+ binding site [ion binding]; other site
546414006406	Mg2+ binding site [ion binding]; other site
546414006407	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
546414006408	Diphthamide biosynthesis methyltransferase [Translation, ribosomal structure and biogenesis]; Region: DPH5; COG1798
546414006409	active site
546414006410	SAM binding site [chemical binding]; other site
546414006411	homodimer interface [polypeptide binding]; other site
546414006412	Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587
546414006413	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
546414006414	active site
546414006415	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
546414006416	Coenzyme A binding pocket [chemical binding]; other site
546414006417	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
546414006418	non-specific DNA binding site [nucleotide binding]; other site
546414006419	salt bridge; other site
546414006420	sequence-specific DNA binding site [nucleotide binding]; other site
546414006421	nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252
546414006422	putative active site pocket [active]
546414006423	cleavage site
546414006424	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
546414006425	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
546414006426	active site
546414006427	phosphorylation site [posttranslational modification]
546414006428	intermolecular recognition site; other site
546414006429	dimerization interface [polypeptide binding]; other site
546414006430	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
546414006431	DNA binding site [nucleotide binding]
546414006432	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
546414006433	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
546414006434	glucose-1-phosphate thymidylylransferase, long form; Region: rmlA_long; TIGR01208
546414006435	active site
546414006436	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
546414006437	putative trimer interface [polypeptide binding]; other site
546414006438	putative CoA binding site [chemical binding]; other site
546414006439	hypothetical protein; Validated; Region: PRK00110
546414006440	Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574
546414006441	YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300
546414006442	active site
546414006443	Response regulator containing CheY-like receiver and SARP domains [Signal transduction mechanisms]; Region: COG3947
546414006444	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
546414006445	active site
546414006446	phosphorylation site [posttranslational modification]
546414006447	intermolecular recognition site; other site
546414006448	dimerization interface [polypeptide binding]; other site
546414006449	lysozyme_like domain.  This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222
546414006450	CHAP domain; Region: CHAP; pfam05257
546414006451	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
546414006452	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673
546414006453	motif 1; other site
546414006454	active site
546414006455	motif 2; other site
546414006456	motif 3; other site
546414006457	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973
546414006458	Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315
546414006459	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
546414006460	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
546414006461	active site
546414006462	metal binding site [ion binding]; metal-binding site
546414006463	Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897
546414006464	Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448
546414006465	active site residue [active]
546414006466	Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449
546414006467	active site residue [active]
546414006468	Fe-S metabolism associated domain; Region: SufE; cl00951
546414006469	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
546414006470	active site
546414006471	dimerization interface [polypeptide binding]; other site
546414006472	D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429
546414006473	D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666
546414006474	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
546414006475	4Fe-4S binding domain; Region: Fer4; pfam00037
546414006476	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
546414006477	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
546414006478	Protein of unknown function (DUF454); Region: DUF454; cl01063
546414006479	ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372
546414006480	Cysteine-rich 4 helical bundle widely conserved in bacteria; Region: DUF326; cd08026
546414006481	dimerization interface [polypeptide binding]; other site
546414006482	competence damage-inducible protein A; Provisional; Region: PRK00549
546414006483	Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885
546414006484	putative MPT binding site; other site
546414006485	Competence-damaged protein; Region: CinA; cl00666
546414006486	2'-5' RNA ligase [Translation, ribosomal structure and biogenesis]; Region: LigT; COG1514
546414006487	LigT like Phosphoesterase; Region: LigT_PEase; pfam02834
546414006488	LigT like Phosphoesterase; Region: LigT_PEase; pfam02834
546414006489	recombinase A; Provisional; Region: recA; PRK09354
546414006490	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
546414006491	hexamer interface [polypeptide binding]; other site
546414006492	Walker A motif; other site
546414006493	ATP binding site [chemical binding]; other site
546414006494	Walker B motif; other site
546414006495	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830
546414006496	BioY family; Region: BioY; pfam02632
546414006497	HTH domain; Region: HTH_11; cl17392
546414006498	Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340
546414006499	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099
546414006500	Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237
546414006501	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
546414006502	metal binding site 2 [ion binding]; metal-binding site
546414006503	putative DNA binding helix; other site
546414006504	metal binding site 1 [ion binding]; metal-binding site
546414006505	dimer interface [polypeptide binding]; other site
546414006506	structural Zn2+ binding site [ion binding]; other site
546414006507	Multiple antibiotic transporter [Intracellular trafficking and secretion]; Region: MarC; COG2095
546414006508	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
546414006509	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
546414006510	active site
546414006511	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215
546414006512	Response regulator receiver domain; Region: Response_reg; pfam00072
546414006513	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
546414006514	active site
546414006515	phosphorylation site [posttranslational modification]
546414006516	intermolecular recognition site; other site
546414006517	dimerization interface [polypeptide binding]; other site
546414006518	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
546414006519	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
546414006520	active site
546414006521	phosphorylation site [posttranslational modification]
546414006522	intermolecular recognition site; other site
546414006523	dimerization interface [polypeptide binding]; other site
546414006524	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
546414006525	DNA binding site [nucleotide binding]
546414006526	mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595
546414006527	Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753
546414006528	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
546414006529	Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740
546414006530	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
546414006531	oligomer interface [polypeptide binding]; other site
546414006532	active site residues [active]
546414006533	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
546414006534	ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689
546414006535	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
546414006536	Walker A motif; other site
546414006537	ATP binding site [chemical binding]; other site
546414006538	Walker B motif; other site
546414006539	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
546414006540	ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466
546414006541	Found in ATP-dependent protease La (LON); Region: LON; smart00464
546414006542	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
546414006543	Walker A motif; other site
546414006544	ATP binding site [chemical binding]; other site
546414006545	Walker B motif; other site
546414006546	arginine finger; other site
546414006547	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
546414006548	Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805
546414006549	SPOC domain; Region: SPOC; pfam07744
546414006550	Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131
546414006551	Walker A motif; other site
546414006552	ATP binding site [chemical binding]; other site
546414006553	Walker B motif; other site
546414006554	Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157
546414006555	Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157
546414006556	Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157
546414006557	Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804
546414006558	PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129
546414006559	Walker A motif; other site
546414006560	ATP binding site [chemical binding]; other site
546414006561	Walker B motif; other site
546414006562	Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179
546414006563	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
546414006564	motif II; other site
546414006565	Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496
546414006566	Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578
546414006567	Enoyl-[acyl-carrier-protein]; Region: FabI; COG0623
546414006568	Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372
546414006569	NAD binding site [chemical binding]; other site
546414006570	homotetramer interface [polypeptide binding]; other site
546414006571	homodimer interface [polypeptide binding]; other site
546414006572	substrate binding site [chemical binding]; other site
546414006573	active site
546414006574	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220
546414006575	catalytic triad [active]
546414006576	Transcriptional regulator [Transcription]; Region: IclR; COG1414
546414006577	IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339
546414006578	Bacterial transcriptional regulator; Region: IclR; pfam01614
546414006579	Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912
546414006580	Dynamin family; Region: Dynamin_N; pfam00350
546414006581	G1 box; other site
546414006582	GTP/Mg2+ binding site [chemical binding]; other site
546414006583	G2 box; other site
546414006584	Switch I region; other site
546414006585	G3 box; other site
546414006586	Switch II region; other site
546414006587	G4 box; other site
546414006588	G5 box; other site
546414006589	Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110
546414006590	Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647
546414006591	trimer interface [polypeptide binding]; other site
546414006592	active site
546414006593	substrate binding site [chemical binding]; other site
546414006594	CoA binding site [chemical binding]; other site
546414006595	metal-dependent hydrolase; Provisional; Region: PRK00685
546414006596	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
546414006597	Uncharacterized conserved protein [Function unknown]; Region: COG1624
546414006598	DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457
546414006599	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
546414006600	Zn2+ binding site [ion binding]; other site
546414006601	Mg2+ binding site [ion binding]; other site
546414006602	Transcriptional regulator [Transcription]; Region: LytR; COG1316
546414006603	LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399
546414006604	Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799
546414006605	Protein of unknown function (DUF3809); Region: DUF3809; pfam12723
546414006606	Protein of unknown function (DUF3248); Region: DUF3248; pfam11609
546414006607	Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602
546414006608	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
546414006609	S-adenosylmethionine binding site [chemical binding]; other site
546414006610	phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168
546414006611	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
546414006612	active site
546414006613	(T/H)XGH motif; other site
546414006614	S-adenosylmethionine synthetase; Validated; Region: PRK05250
546414006615	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
546414006616	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
546414006617	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
546414006618	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
546414006619	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
546414006620	active site
546414006621	phosphorylation site [posttranslational modification]
546414006622	intermolecular recognition site; other site
546414006623	dimerization interface [polypeptide binding]; other site
546414006624	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
546414006625	DNA binding site [nucleotide binding]
546414006626	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
546414006627	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
546414006628	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
546414006629	dimer interface [polypeptide binding]; other site
546414006630	phosphorylation site [posttranslational modification]
546414006631	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
546414006632	ATP binding site [chemical binding]; other site
546414006633	Mg2+ binding site [ion binding]; other site
546414006634	G-X-G motif; other site
546414006635	phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135
546414006636	PhoU domain; Region: PhoU; pfam01895
546414006637	PhoU domain; Region: PhoU; pfam01895
546414006638	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
546414006639	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
546414006640	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
546414006641	Walker A/P-loop; other site
546414006642	ATP binding site [chemical binding]; other site
546414006643	Q-loop/lid; other site
546414006644	ABC transporter signature motif; other site
546414006645	Walker B; other site
546414006646	D-loop; other site
546414006647	H-loop/switch region; other site
546414006648	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
546414006649	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
546414006650	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
546414006651	Walker A/P-loop; other site
546414006652	ATP binding site [chemical binding]; other site
546414006653	Q-loop/lid; other site
546414006654	ABC transporter signature motif; other site
546414006655	Walker B; other site
546414006656	D-loop; other site
546414006657	H-loop/switch region; other site
546414006658	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
546414006659	active site
546414006660	RNase H is an endonuclease that cleaves the RNA strand of an RNA/DNA hybrid in a sequence non-specific manner; Region: RNase_H; cd06222
546414006661	RNA/DNA hybrid binding site [nucleotide binding]; other site
546414006662	active site
546414006663	Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305
546414006664	Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032
546414006665	E-class dimer interface [polypeptide binding]; other site
546414006666	P-class dimer interface [polypeptide binding]; other site
546414006667	active site
546414006668	Cu2+ binding site [ion binding]; other site
546414006669	Zn2+ binding site [ion binding]; other site
546414006670	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
546414006671	mycothiol synthase; Region: mycothiol_MshD; TIGR03448
546414006672	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
546414006673	Coenzyme A binding pocket [chemical binding]; other site
546414006674	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
546414006675	Coenzyme A binding pocket [chemical binding]; other site
546414006676	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
546414006677	Coenzyme A binding pocket [chemical binding]; other site
546414006678	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
546414006679	Uncharacterized proteins, LmbE homologs [Function unknown]; Region: COG2120
546414006680	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
546414006681	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
546414006682	metal binding site [ion binding]; metal-binding site
546414006683	active site
546414006684	I-site; other site
546414006685	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
546414006686	hypothetical protein; Provisional; Region: PRK07338
546414006687	M20 Peptidase Glutamate carboxypeptidase, a periplasmic enzyme; Region: M20_CPDG2; cd03885
546414006688	metal binding site [ion binding]; metal-binding site
546414006689	dimer interface [polypeptide binding]; other site
546414006690	Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506
546414006691	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
546414006692	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
546414006693	RIO kinase family, catalytic domain. The RIO kinase catalytic domain family is part of a larger superfamily, that includes the catalytic domains of other kinases such as the typical serine/threonine/tyrosine protein kinases (PKs), aminoglycoside...; Region: RIO; cl17248
546414006694	ATP binding site [chemical binding]; other site
546414006695	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_13; cd08354
546414006696	putative metal binding site [ion binding]; other site
546414006697	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
546414006698	Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301
546414006699	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315
546414006700	DNA binding residues [nucleotide binding]
546414006701	YeiC-like sugar kinase.  Found in eukaryotes and bacteria, YeiC-like kinase is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time; Region: YeiC_kinase_like; cd01941
546414006702	Indigoidine synthase A like protein; Region: Indigoidine_A; pfam04227
546414006703	bifunctional nicotinamide mononucleotide adenylyltransferase/ADP-ribose pyrophosphatase; Provisional; Region: PRK05379
546414006704	Nicotinamide/nicotinate mononucleotide adenylyltransferase of bifunctional proteins, also containing a Nudix hydrolase domain; Region: NMNAT_Nudix; cd02168
546414006705	active site
546414006706	(T/H)XGH motif; other site
546414006707	ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051
546414006708	nudix motif; other site
546414006709	autolysin; Reviewed; Region: PRK06347
546414006710	Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724
546414006711	Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724
546414006712	Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422
546414006713	active site
546414006714	dimer interfaces [polypeptide binding]; other site
546414006715	catalytic residues [active]
546414006716	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
546414006717	active site
546414006718	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
546414006719	homotrimer interaction site [polypeptide binding]; other site
546414006720	putative active site [active]
546414006721	Uncharacterized homolog of PSP1 [Function unknown]; Region: COG1774
546414006722	oligoendopeptidase, M3 family; Region: M3_not_pepF; TIGR02289
546414006723	Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_1; cd09606
546414006724	active site
546414006725	Zn binding site [ion binding]; other site
546414006726	Domain of unknown function (DUF4384); Region: DUF4384; pfam14326
546414006727	PEGA domain; Region: PEGA; pfam08308
546414006728	mycothiol synthase; Region: mycothiol_MshD; TIGR03448
546414006729	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
546414006730	Coenzyme A binding pocket [chemical binding]; other site
546414006731	metal-dependent hydrolase; Provisional; Region: PRK13291
546414006732	DinB superfamily; Region: DinB_2; pfam12867
546414006733	malate dehydrogenase; Provisional; Region: PRK13529
546414006734	Malic enzyme, N-terminal domain; Region: malic; pfam00390
546414006735	NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312
546414006736	NAD(P) binding site [chemical binding]; other site
546414006737	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440
546414006738	active site 2 [active]
546414006739	active site 1 [active]
546414006740	Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631
546414006741	HisA.  Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732
546414006742	phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007
546414006743	catalytic residues [active]
546414006744	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
546414006745	This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1; Region: GT1_UGDG_like; cd03817
546414006746	putative ADP-binding pocket [chemical binding]; other site
546414006747	Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505
546414006748	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
546414006749	Formiminotransferase-cyclodeaminase; Region: FTCD_C; cl01350
546414006750	Putative esterase; Region: Esterase; pfam00756
546414006751	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819
546414006752	malate dehydrogenase; Provisional; Region: PRK05442
546414006753	Chloroplast-like malate dehydrogenases; Region: MDH_choloroplast_like; cd01338
546414006754	NAD(P) binding site [chemical binding]; other site
546414006755	dimer interface [polypeptide binding]; other site
546414006756	malate binding site [chemical binding]; other site
546414006757	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
546414006758	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
546414006759	substrate binding site [chemical binding]; other site
546414006760	oxyanion hole (OAH) forming residues; other site
546414006761	trimer interface [polypeptide binding]; other site
546414006762	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762
546414006763	dTDP-4-dehydrorhamnose reductase [Cell envelope biogenesis, outer membrane]; Region: RfbD; COG1091
546414006764	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
546414006765	NAD(P) binding site [chemical binding]; other site
546414006766	active site
546414006767	Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086
546414006768	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
546414006769	UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237
546414006770	NAD(P) binding site [chemical binding]; other site
546414006771	homodimer interface [polypeptide binding]; other site
546414006772	substrate binding site [chemical binding]; other site
546414006773	active site
546414006774	Bacterial sugar transferase; Region: Bac_transf; pfam02397
546414006775	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
546414006776	NADH(P)-binding; Region: NAD_binding_10; pfam13460
546414006777	NAD(P) binding site [chemical binding]; other site
546414006778	active site
546414006779	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
546414006780	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
546414006781	This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808
546414006782	putative ADP-binding pocket [chemical binding]; other site
546414006783	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
546414006784	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
546414006785	UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253
546414006786	putative NAD(P) binding site [chemical binding]; other site
546414006787	active site
546414006788	putative substrate binding site [chemical binding]; other site
546414006789	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
546414006790	UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677
546414006791	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
546414006792	UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984
546414006793	exosortase A system-associated amidotransferase 1; Region: eps_aminotran_1; TIGR03108
546414006794	Glutamine amidotransferases class-II (GATase) asparagine synthase_B type.  Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a  glutaminase domain and a...; Region: AsnB; cd00712
546414006795	active site
546414006796	dimer interface [polypeptide binding]; other site
546414006797	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
546414006798	Ligand Binding Site [chemical binding]; other site
546414006799	Molecular Tunnel; other site
546414006800	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
546414006801	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
546414006802	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
546414006803	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
546414006804	Probable Catalytic site; other site
546414006805	metal-binding site
546414006806	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
546414006807	dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfbC; COG1898
546414006808	G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538
546414006809	glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207
546414006810	substrate binding site; other site
546414006811	tetramer interface; other site
546414006812	dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088
546414006813	dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246
546414006814	NAD binding site [chemical binding]; other site
546414006815	substrate binding site [chemical binding]; other site
546414006816	homodimer interface [polypeptide binding]; other site
546414006817	active site
546414006818	Chain length determinant protein; Region: Wzz; cl15801
546414006819	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489
546414006820	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
546414006821	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
546414006822	Major Facilitator Superfamily; Region: MFS_1; pfam07690
546414006823	putative substrate translocation pore; other site
546414006824	putative sulfite oxidase subunit YedZ; Reviewed; Region: PRK05419
546414006825	Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041
546414006826	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
546414006827	Moco binding site; other site
546414006828	metal coordination site [ion binding]; other site
546414006829	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215
546414006830	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
546414006831	catalytic core [active]
546414006832	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
546414006833	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
546414006834	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
546414006835	metal binding site [ion binding]; metal-binding site
546414006836	active site
546414006837	I-site; other site
546414006838	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
546414006839	Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744
546414006840	Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354
546414006841	ligand binding site [chemical binding]; other site
546414006842	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
546414006843	Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_3; cd06336
546414006844	putative ligand binding site [chemical binding]; other site
546414006845	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
546414006846	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
546414006847	TM-ABC transporter signature motif; other site
546414006848	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
546414006849	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
546414006850	TM-ABC transporter signature motif; other site
546414006851	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
546414006852	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
546414006853	Walker A/P-loop; other site
546414006854	ATP binding site [chemical binding]; other site
546414006855	Q-loop/lid; other site
546414006856	ABC transporter signature motif; other site
546414006857	Walker B; other site
546414006858	D-loop; other site
546414006859	H-loop/switch region; other site
546414006860	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
546414006861	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
546414006862	Walker A/P-loop; other site
546414006863	ATP binding site [chemical binding]; other site
546414006864	Q-loop/lid; other site
546414006865	ABC transporter signature motif; other site
546414006866	Walker B; other site
546414006867	D-loop; other site
546414006868	H-loop/switch region; other site
546414006869	Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910
546414006870	C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663
546414006871	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
546414006872	Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290
546414006873	PAS domain; Region: PAS_8; pfam13188
546414006874	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
546414006875	ATP binding site [chemical binding]; other site
546414006876	Mg2+ binding site [ion binding]; other site
546414006877	G-X-G motif; other site
546414006878	Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565
546414006879	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
546414006880	active site
546414006881	phosphorylation site [posttranslational modification]
546414006882	intermolecular recognition site; other site
546414006883	dimerization interface [polypeptide binding]; other site
546414006884	dihydrolipoamide dehydrogenase; Validated; Region: PRK06327
546414006885	Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730
546414006886	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
546414006887	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
546414006888	Predicted metal-binding, possibly nucleic acid-binding protein [General function prediction only]; Region: COG1399
546414006889	MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420
546414006890	trimer interface [polypeptide binding]; other site
546414006891	dimer interface [polypeptide binding]; other site
546414006892	putative active site [active]
546414006893	Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519
546414006894	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
546414006895	sequence-specific DNA binding site [nucleotide binding]; other site
546414006896	salt bridge; other site
546414006897	Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460
546414006898	Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317
546414006899	active site
546414006900	Zn binding site [ion binding]; other site
546414006901	Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285
546414006902	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
546414006903	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
546414006904	putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427
546414006905	DHH family; Region: DHH; pfam01368
546414006906	DHHA2 domain; Region: DHHA2; pfam02833
546414006907	S-layer homology domain; Region: SLH; pfam00395
546414006908	Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; Region: SPEC; cd00176
546414006909	linker region; other site
546414006910	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112
546414006911	Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343
546414006912	Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754
546414006913	MoaE interaction surface [polypeptide binding]; other site
546414006914	MoeB interaction surface [polypeptide binding]; other site
546414006915	thiocarboxylated glycine; other site
546414006916	MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756
546414006917	MoaE homodimer interface [polypeptide binding]; other site
546414006918	MoaD interaction [polypeptide binding]; other site
546414006919	active site residues [active]
546414006920	Membrane proteinase, regulator of anti-sigma factor [Posttranslational modification, protein turnover, chaperones]; Region: prsW; COG2339
546414006921	Holliday junction resolvasome, endonuclease subunit [DNA replication, recombination, and repair]; Region: RuvC; COG0817
546414006922	active site
546414006923	putative DNA-binding cleft [nucleotide binding]; other site
546414006924	dimer interface [polypeptide binding]; other site
546414006925	Iron-sulfur cluster assembly accessory protein; Region: TIGR00049
546414006926	Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290
546414006927	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859
546414006928	heme bH binding site [chemical binding]; other site
546414006929	Qi binding site; other site
546414006930	intrachain domain interface; other site
546414006931	heme bL binding site [chemical binding]; other site
546414006932	interchain domain interface [polypeptide binding]; other site
546414006933	Qo binding site; other site
546414006934	Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723
546414006935	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467
546414006936	iron-sulfur cluster [ion binding]; other site
546414006937	[2Fe-2S] cluster binding site [ion binding]; other site
546414006938	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
546414006939	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
546414006940	Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354
546414006941	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
546414006942	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
546414006943	active site
546414006944	phosphorylation site [posttranslational modification]
546414006945	intermolecular recognition site; other site
546414006946	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
546414006947	DNA binding residues [nucleotide binding]
546414006948	dimerization interface [polypeptide binding]; other site
546414006949	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
546414006950	EamA-like transporter family; Region: EamA; pfam00892
546414006951	EamA-like transporter family; Region: EamA; pfam00892
546414006952	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
546414006953	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
546414006954	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
546414006955	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
546414006956	active site
546414006957	phosphorylation site [posttranslational modification]
546414006958	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
546414006959	dimerization domain swap beta strand [polypeptide binding]; other site
546414006960	regulatory protein interface [polypeptide binding]; other site
546414006961	active site
546414006962	regulatory phosphorylation site [posttranslational modification]; other site
546414006963	Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080
546414006964	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
546414006965	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
546414006966	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
546414006967	Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105
546414006968	1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164
546414006969	putative substrate binding site [chemical binding]; other site
546414006970	putative ATP binding site [chemical binding]; other site
546414006971	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
546414006972	active site
546414006973	P-loop; other site
546414006974	phosphorylation site [posttranslational modification]
546414006975	PTS system fructose-specific transporter subunits IIBC; Provisional; Region: PRK10712
546414006976	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
546414006977	active site
546414006978	P-loop; other site
546414006979	phosphorylation site [posttranslational modification]
546414006980	Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299
546414006981	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
546414006982	S-adenosylmethionine binding site [chemical binding]; other site
546414006983	TM2 domain; Region: TM2; pfam05154
546414006984	O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873
546414006985	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
546414006986	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
546414006987	catalytic residue [active]
546414006988	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
546414006989	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
546414006990	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
546414006991	nudix motif; other site
546414006992	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
546414006993	nudix motif; other site
546414006994	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
546414006995	DDE superfamily endonuclease; Region: DDE_4; cl17710
546414006996	DDE superfamily endonuclease; Region: DDE_4; cl17710
546414006997	Predicted Zn-dependent protease (DUF2268); Region: DUF2268; cl02316
546414006998	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
546414006999	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
546414007000	putative tRNA-binding site [nucleotide binding]; other site
546414007001	B3/4 domain; Region: B3_4; pfam03483
546414007002	tRNA synthetase B5 domain; Region: B5; smart00874
546414007003	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
546414007004	dimer interface [polypeptide binding]; other site
546414007005	motif 1; other site
546414007006	motif 3; other site
546414007007	motif 2; other site
546414007008	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147
546414007009	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
546414007010	nudix motif; other site
546414007011	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
546414007012	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
546414007013	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
546414007014	dimer interface [polypeptide binding]; other site
546414007015	motif 1; other site
546414007016	active site
546414007017	motif 2; other site
546414007018	motif 3; other site
546414007019	ABC-type uncharacterized transport system; Region: ABC_transp_aux; pfam09822
546414007020	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
546414007021	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
546414007022	dimer interface [polypeptide binding]; other site
546414007023	active site
546414007024	glycine-pyridoxal phosphate binding site [chemical binding]; other site
546414007025	folate binding site [chemical binding]; other site
546414007026	glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810
546414007027	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
546414007028	glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750
546414007029	Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713
546414007030	active site
546414007031	dimer interface [polypeptide binding]; other site
546414007032	Glutamate synthase central domain; Region: Glu_syn_central; pfam04898
546414007033	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
546414007034	active site
546414007035	FMN binding site [chemical binding]; other site
546414007036	substrate binding site [chemical binding]; other site
546414007037	3Fe-4S cluster binding site [ion binding]; other site
546414007038	gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982
546414007039	domain interface; other site
546414007040	Predicted membrane protein (DUF2157); Region: DUF2157; cl10480
546414007041	GDYXXLXY protein; Region: GDYXXLXY; pfam14345
546414007042	Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385
546414007043	putative active site [active]
546414007044	putative metal binding site [ion binding]; other site
546414007045	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
546414007046	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
546414007047	active site
546414007048	metal binding site [ion binding]; metal-binding site
546414007049	Carbon monoxide dehydrogenase subunit G (CoxG); Region: CoxG; cd05018
546414007050	putative hydrophobic ligand binding site [chemical binding]; other site
546414007051	ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277
546414007052	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
546414007053	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
546414007054	Walker A/P-loop; other site
546414007055	ATP binding site [chemical binding]; other site
546414007056	Q-loop/lid; other site
546414007057	ABC transporter signature motif; other site
546414007058	Walker B; other site
546414007059	D-loop; other site
546414007060	H-loop/switch region; other site
546414007061	voltage-dependent potassium channel beta subunit, animal; Region: Kv_beta; TIGR01293
546414007062	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
546414007063	active site
546414007064	catalytic tetrad [active]
546414007065	Peptidase family M48; Region: Peptidase_M48; cl12018
546414007066	rod shape-determining protein RodA; Region: rodA_shape; TIGR02210
546414007067	cell division topological specificity factor MinE; Region: minE; TIGR01215
546414007068	septum site-determining protein MinD; Region: minD_bact; TIGR01968
546414007069	Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036
546414007070	Switch I; other site
546414007071	Switch II; other site
546414007072	ribosomal protein S12 methylthiotransferase; Provisional; Region: rimO; PRK14862
546414007073	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
546414007074	Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070
546414007075	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
546414007076	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
546414007077	FMN binding site [chemical binding]; other site
546414007078	substrate binding site [chemical binding]; other site
546414007079	putative catalytic residue [active]
546414007080	Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989
546414007081	Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750
546414007082	Type IV leader peptidase family; Region: Peptidase_A24; pfam01478
546414007083	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
546414007084	NAD(P) binding site [chemical binding]; other site
546414007085	catalytic residues [active]
546414007086	molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317
546414007087	MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503
546414007088	GTP binding site; other site
546414007089	OsmC-like protein; Region: OsmC; pfam02566
546414007090	Protein of unknown function (DUF1622); Region: DUF1622; pfam07784
546414007091	Domain of unknown function (DUF4385); Region: DUF4385; pfam14328
546414007092	DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783
546414007093	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
546414007094	dimerization interface [polypeptide binding]; other site
546414007095	DPS ferroxidase diiron center [ion binding]; other site
546414007096	ion pore; other site
546414007097	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
546414007098	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
546414007099	multidrug resistance protein MdtH; Provisional; Region: PRK11646
546414007100	putative substrate translocation pore; other site
546414007101	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
546414007102	Tricorn protease; serine protease family S41; Region: Peptidase_S41_TRI; cd07562
546414007103	Domain interface; other site
546414007104	Peptide binding site; other site
546414007105	Active site tetrad [active]
546414007106	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
546414007107	Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624
546414007108	metal binding site [ion binding]; metal-binding site
546414007109	EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cl17302
546414007110	Ca2+ binding site [ion binding]; other site
546414007111	hypothetical protein; Provisional; Region: PRK02395
546414007112	Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416
546414007113	putative active site [active]
546414007114	Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416
546414007115	putative active site [active]
546414007116	phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362
546414007117	bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415
546414007118	active site
546414007119	ATP binding site [chemical binding]; other site
546414007120	substrate binding site [chemical binding]; other site
546414007121	Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; pfam02700
546414007122	Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662
546414007123	phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619
546414007124	Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
546414007125	putative active site [active]
546414007126	catalytic triad [active]
546414007127	DinB superfamily; Region: DinB_2; pfam12867
546414007128	phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213
546414007129	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203
546414007130	dimerization interface [polypeptide binding]; other site
546414007131	ATP binding site [chemical binding]; other site
546414007132	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204
546414007133	dimerization interface [polypeptide binding]; other site
546414007134	ATP binding site [chemical binding]; other site
546414007135	amidophosphoribosyltransferase; Region: purF; TIGR01134
546414007136	Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of  glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715
546414007137	active site
546414007138	tetramer interface [polypeptide binding]; other site
546414007139	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
546414007140	active site
546414007141	conserved hypothetical protein; Region: TIGR03833
546414007142	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
546414007143	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
546414007144	protein binding site [polypeptide binding]; other site
546414007145	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
546414007146	Trehalose-phosphatase; Region: Trehalose_PPase; pfam02358
546414007147	active site
546414007148	motif I; other site
546414007149	motif II; other site
546414007150	alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400
546414007151	Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788
546414007152	active site
546414007153	homotetramer interface [polypeptide binding]; other site
546414007154	Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386
546414007155	2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404
546414007156	Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016
546414007157	TPP-binding site [chemical binding]; other site
546414007158	Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779
546414007159	dihydrolipoamide succinyltransferase; Validated; Region: PRK05704
546414007160	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
546414007161	E3 interaction surface; other site
546414007162	lipoyl attachment site [posttranslational modification]; other site
546414007163	e3 binding domain; Region: E3_binding; pfam02817
546414007164	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
546414007165	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
546414007166	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
546414007167	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
546414007168	Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040
546414007169	7TMR-DISM extracellular 2; Region: 7TMR-DISMED2; pfam07696
546414007170	7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695
546414007171	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
546414007172	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
546414007173	metal binding site [ion binding]; metal-binding site
546414007174	active site
546414007175	I-site; other site
546414007176	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
546414007177	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
546414007178	glutaminase active site [active]
546414007179	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
546414007180	dimer interface [polypeptide binding]; other site
546414007181	active site
546414007182	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
546414007183	dimer interface [polypeptide binding]; other site
546414007184	active site
546414007185	Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626
546414007186	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
546414007187	homodimer interface [polypeptide binding]; other site
546414007188	substrate-cofactor binding pocket; other site
546414007189	pyridoxal 5'-phosphate binding site [chemical binding]; other site
546414007190	catalytic residue [active]
546414007191	Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993
546414007192	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
546414007193	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
546414007194	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
546414007195	Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428
546414007196	Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673
546414007197	Substrate-binding site [chemical binding]; other site
546414007198	Substrate specificity [chemical binding]; other site
546414007199	Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428
546414007200	Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673
546414007201	Substrate-binding site [chemical binding]; other site
546414007202	Substrate specificity [chemical binding]; other site
546414007203	UDP-N-acetylmuramyl-tripeptide synthetase; Region: murE; TIGR01085
546414007204	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
546414007205	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
546414007206	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
546414007207	Uncharacterized conserved protein [Function unknown]; Region: RtcB; COG1690
546414007208	hypothetical protein; Reviewed; Region: PRK09588
546414007209	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
546414007210	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
546414007211	putative active site [active]
546414007212	heme pocket [chemical binding]; other site
546414007213	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
546414007214	Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086
546414007215	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
546414007216	heme pocket [chemical binding]; other site
546414007217	putative active site [active]
546414007218	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
546414007219	GAF domain; Region: GAF_3; pfam13492
546414007220	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
546414007221	dimer interface [polypeptide binding]; other site
546414007222	phosphorylation site [posttranslational modification]
546414007223	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
546414007224	ATP binding site [chemical binding]; other site
546414007225	Mg2+ binding site [ion binding]; other site
546414007226	G-X-G motif; other site
546414007227	Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637
546414007228	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
546414007229	motif II; other site
546414007230	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
546414007231	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
546414007232	Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409
546414007233	Aminoglycoside 3'-phosphotransferase (APH). The APH subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin...; Region: APH; cd05150
546414007234	Phosphotransferase enzyme family; Region: APH; pfam01636
546414007235	active site
546414007236	ATP binding site [chemical binding]; other site
546414007237	antibiotic binding site [chemical binding]; other site
546414007238	CoA enzyme activase uncharacterized domain (DUF2229); Region: DUF2229; cl17855
546414007239	Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms]; Region: NtrY; COG5000
546414007240	Predicted integral membrane protein [Function unknown]; Region: COG5530
546414007241	Peptidase S8 family domain in Subtilisin-like proteins; Region: Peptidases_S8_Subtilisin_like; cd07473
546414007242	catalytic triad [active]
546414007243	putative active site [active]
546414007244	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
546414007245	DNA polymerase III, delta' subunit; Region: holB; TIGR00678
546414007246	DNA polymerase III subunit delta'; Validated; Region: PRK08485
546414007247	Calcineurin-like phosphoesterase superfamily domain; Region: Metallophos_2; pfam12850
546414007248	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
546414007249	active site
546414007250	metal binding site [ion binding]; metal-binding site
546414007251	Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062
546414007252	putative dimer interface [polypeptide binding]; other site
546414007253	catalytic triad [active]
546414007254	Protein of unknown function (DUF1440); Region: DUF1440; cl01380
546414007255	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
546414007256	classical (c) SDRs; Region: SDR_c; cd05233
546414007257	NAD(P) binding site [chemical binding]; other site
546414007258	active site
546414007259	Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831
546414007260	Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424
546414007261	malonyl-CoA binding site [chemical binding]; other site
546414007262	dimer interface [polypeptide binding]; other site
546414007263	active site
546414007264	product binding site; other site
546414007265	2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1, 4-benzoquinol methylase [Coenzyme metabolism]; Region: UbiG; COG2227
546414007266	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
546414007267	S-adenosylmethionine binding site [chemical binding]; other site
546414007268	2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654
546414007269	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
546414007270	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
546414007271	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
546414007272	Coenzyme A binding pocket [chemical binding]; other site
546414007273	Uncharacterized subgroup of the nitrilase superfamily; some members of this subgroup have an N-terminal RimI domain (class 12 nitrilases); Region: nitrilase_Rim1_like; cd07574
546414007274	Predicted amidohydrolase [General function prediction only]; Region: COG0388
546414007275	putative active site [active]
546414007276	catalytic triad [active]
546414007277	putative dimer interface [polypeptide binding]; other site
546414007278	5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212; cl00360
546414007279	DinB superfamily; Region: DinB_2; pfam12867
546414007280	Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716
546414007281	pilus retraction protein PilT; Region: pilT_fam; TIGR01420
546414007282	Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131
546414007283	Walker A motif; other site
546414007284	ATP binding site [chemical binding]; other site
546414007285	Walker B motif; other site
546414007286	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
546414007287	TPR motif; other site
546414007288	Tetratricopeptide repeat; Region: TPR_12; pfam13424
546414007289	binding surface
546414007290	Tetratricopeptide repeat; Region: TPR_12; pfam13424
546414007291	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
546414007292	binding surface
546414007293	TPR motif; other site
546414007294	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
546414007295	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
546414007296	metal binding site [ion binding]; metal-binding site
546414007297	active site
546414007298	I-site; other site
546414007299	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
546414007300	Cysteine-rich 4 helical bundle widely conserved in bacteria; Region: DUF326; cd08026
546414007301	dimerization interface [polypeptide binding]; other site
546414007302	Protein of unknown function (DUF2726); Region: DUF2726; pfam10881
546414007303	Protein of unknown function, DUF488; Region: DUF488; pfam04343
546414007304	Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019
546414007305	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme PvsE; Region: PLPDE_III_PvsE_like; cd06843
546414007306	dimer interface [polypeptide binding]; other site
546414007307	active site
546414007308	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
546414007309	catalytic residues [active]
546414007310	substrate binding site [chemical binding]; other site
546414007311	Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264
546414007312	IucA / IucC family; Region: IucA_IucC; pfam04183
546414007313	Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276
546414007314	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
546414007315	Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264
546414007316	IucA / IucC family; Region: IucA_IucC; pfam04183
546414007317	ATP-grasp domain; Region: ATP-grasp_4; pfam13535
546414007318	Fe3+-siderophore binding domain FhuD.  These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146
546414007319	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
546414007320	siderophore binding site; other site
546414007321	Protein of unknown function DUF72; Region: DUF72; pfam01904
546414007322	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113
546414007323	PHP domain; Region: PHP; pfam02811
546414007324	active site
546414007325	PHP Thumb interface [polypeptide binding]; other site
546414007326	metal binding site [ion binding]; metal-binding site
546414007327	Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733
546414007328	DNA polymerase III subunit alpha; Reviewed; Region: PRK07373
546414007329	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
546414007330	generic binding surface II; other site
546414007331	generic binding surface I; other site
546414007332	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
546414007333	PAS domain; Region: PAS_9; pfam13426
546414007334	putative active site [active]
546414007335	heme pocket [chemical binding]; other site
546414007336	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
546414007337	Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234
546414007338	nucleotide binding site [chemical binding]; other site
546414007339	NEF interaction site [polypeptide binding]; other site
546414007340	SBD interface [polypeptide binding]; other site
546414007341	Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576
546414007342	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
546414007343	dimer interface [polypeptide binding]; other site
546414007344	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
546414007345	Uncharacterized conserved protein (DUF2132); Region: DUF2132; pfam09905
546414007346	chaperone protein DnaJ; Provisional; Region: PRK14299
546414007347	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
546414007348	HSP70 interaction site [polypeptide binding]; other site
546414007349	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
546414007350	substrate binding site [polypeptide binding]; other site
546414007351	dimer interface [polypeptide binding]; other site
546414007352	FOG: CBS domain [General function prediction only]; Region: COG0517
546414007353	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622
546414007354	Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404
546414007355	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
546414007356	active site
546414007357	catalytic residues [active]
546414007358	hypothetical protein; Provisional; Region: PRK14709
546414007359	fructose-bisphosphate aldolase; Provisional; Region: PRK09197
546414007360	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
546414007361	intersubunit interface [polypeptide binding]; other site
546414007362	active site
546414007363	zinc binding site [ion binding]; other site
546414007364	Na+ binding site [ion binding]; other site
546414007365	Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436
546414007366	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
546414007367	pyridoxal 5'-phosphate binding site [chemical binding]; other site
546414007368	homodimer interface [polypeptide binding]; other site
546414007369	catalytic residue [active]
546414007370	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in uncharacterized protein from Archaeoglobus fulgidus (Af0060) and its bacterial homologs; Region: NTP-PPase_Af0060_like; cd11533
546414007371	homodimer interface [polypeptide binding]; other site
546414007372	metal binding site [ion binding]; metal-binding site
546414007373	glutamate racemase; Provisional; Region: PRK00865
546414007374	aspartate racemase; Region: asp_race; TIGR00035
546414007375	ribonuclease PH; Reviewed; Region: rph; PRK00173
546414007376	Ribonuclease PH; Region: RNase_PH_bact; cd11362
546414007377	hexamer interface [polypeptide binding]; other site
546414007378	active site
546414007379	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
546414007380	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
546414007381	metal binding site [ion binding]; metal-binding site
546414007382	active site
546414007383	I-site; other site
546414007384	CorA-like Mg2+ transporter protein; Region: CorA; pfam01544
546414007385	uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827
546414007386	Cl binding site [ion binding]; other site
546414007387	oligomer interface [polypeptide binding]; other site
546414007388	Ferredoxin [Energy production and conversion]; Region: COG1146
546414007389	4Fe-4S binding domain; Region: Fer4; cl02805
546414007390	MobA-like NTP transferase domain; Region: NTP_transf_3; pfam12804
546414007391	active site
546414007392	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
546414007393	HAMP domain; Region: HAMP; pfam00672
546414007394	dimerization interface [polypeptide binding]; other site
546414007395	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080
546414007396	dimer interface [polypeptide binding]; other site
546414007397	phosphorylation site [posttranslational modification]
546414007398	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
546414007399	ATP binding site [chemical binding]; other site
546414007400	Mg2+ binding site [ion binding]; other site
546414007401	G-X-G motif; other site
546414007402	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
546414007403	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
546414007404	active site
546414007405	phosphorylation site [posttranslational modification]
546414007406	intermolecular recognition site; other site
546414007407	dimerization interface [polypeptide binding]; other site
546414007408	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
546414007409	DNA binding site [nucleotide binding]
546414007410	50S ribosomal protein L21; Validated; Region: rplU; PRK05573
546414007411	50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278
546414007412	50S ribosomal protein L27; Validated; Region: rpmA; PRK05435
546414007413	GTPase CgtA; Reviewed; Region: obgE; PRK12297
546414007414	GTP1/OBG; Region: GTP1_OBG; pfam01018
546414007415	Obg GTPase; Region: Obg; cd01898
546414007416	G1 box; other site
546414007417	GTP/Mg2+ binding site [chemical binding]; other site
546414007418	Switch I region; other site
546414007419	G2 box; other site
546414007420	G3 box; other site
546414007421	Switch II region; other site
546414007422	G4 box; other site
546414007423	G5 box; other site
546414007424	Domain of unknown function (DUF1967); Region: DUF1967; pfam09269
546414007425	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317
546414007426	active site
546414007427	Cytidylate kinase [Nucleotide transport and metabolism]; Region: Cmk; COG0283
546414007428	AAA domain; Region: AAA_17; pfam13207
546414007429	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
546414007430	CMP-binding site; other site
546414007431	The sites determining sugar specificity; other site
546414007432	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
546414007433	active site
546414007434	catalytic residues [active]
546414007435	Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151
546414007436	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
546414007437	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
546414007438	active site
546414007439	OstA-like protein; Region: OstA; cl00844
546414007440	OstA-like protein; Region: OstA; cl00844
546414007441	OstA-like protein; Region: OstA; cl00844
546414007442	NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl17195
546414007443	L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771
546414007444	NAD(P) binding site [chemical binding]; other site
546414007445	LDH/MDH dimer interface [polypeptide binding]; other site
546414007446	substrate binding site [chemical binding]; other site
546414007447	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
546414007448	Ligand Binding Site [chemical binding]; other site
546414007449	Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236
546414007450	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
546414007451	Beta-Casp domain; Region: Beta-Casp; smart01027
546414007452	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
546414007453	Protein of unknown function (DUF3105); Region: DUF3105; pfam11303
546414007454	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
546414007455	S-adenosylmethionine binding site [chemical binding]; other site
546414007456	NLPA lipoprotein; Region: Lipoprotein_9; pfam03180
546414007457	ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464
546414007458	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
546414007459	ABC-ATPase subunit interface; other site
546414007460	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
546414007461	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
546414007462	Walker A/P-loop; other site
546414007463	ATP binding site [chemical binding]; other site
546414007464	Q-loop/lid; other site
546414007465	ABC transporter signature motif; other site
546414007466	Walker B; other site
546414007467	D-loop; other site
546414007468	H-loop/switch region; other site
546414007469	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
546414007470	S-adenosylmethionine binding site [chemical binding]; other site
546414007471	tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335
546414007472	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
546414007473	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
546414007474	active site
546414007475	Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922
546414007476	Peptidase S8 family domain in ProteinaseK-like proteins; Region: Peptidases_S8_PCSK9_ProteinaseK_like; cd04077
546414007477	calcium binding site 2 [ion binding]; other site
546414007478	type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921
546414007479	active site
546414007480	catalytic triad [active]
546414007481	calcium binding site 1 [ion binding]; other site
546414007482	Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151
546414007483	Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333
546414007484	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
546414007485	Protein of unknown function (DUF3006); Region: DUF3006; pfam11213
546414007486	Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312
546414007487	Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312
546414007488	SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; cl01747
546414007489	putative menaquinone biosynthesis protein, SCO4494 family; Region: mena_SCO4494; TIGR03700
546414007490	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
546414007491	FeS/SAM binding site; other site
546414007492	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
546414007493	Predicted periplasmic solute-binding protein [General function prediction only]; Region: COG1427
546414007494	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
546414007495	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
546414007496	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
546414007497	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
546414007498	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
546414007499	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
546414007500	Peptidase family M23; Region: Peptidase_M23; pfam01551
546414007501	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
546414007502	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
546414007503	Coenzyme A binding pocket [chemical binding]; other site
546414007504	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
546414007505	catalytic core [active]
546414007506	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883
546414007507	nudix motif; other site
546414007508	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
546414007509	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
546414007510	nucleoside/Zn binding site; other site
546414007511	dimer interface [polypeptide binding]; other site
546414007512	catalytic motif [active]
546414007513	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
546414007514	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
546414007515	metal binding site [ion binding]; metal-binding site
546414007516	active site
546414007517	I-site; other site
546414007518	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
546414007519	oligomerisation interface [polypeptide binding]; other site
546414007520	mobile loop; other site
546414007521	roof hairpin; other site
546414007522	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
546414007523	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
546414007524	ring oligomerisation interface [polypeptide binding]; other site
546414007525	ATP/Mg binding site [chemical binding]; other site
546414007526	stacking interactions; other site
546414007527	hinge regions; other site
546414007528	Predicted kinase [General function prediction only]; Region: COG0645
546414007529	AAA domain; Region: AAA_17; pfam13207
546414007530	hypothetical protein; Provisional; Region: PRK06762
546414007531	Predicted kinase [General function prediction only]; Region: COG0645
546414007532	acyl-CoA synthetase; Validated; Region: PRK08162
546414007533	Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles and Arabidopsis; Region: ttLC_FACS_AEE21_like; cd12118
546414007534	acyl-activating enzyme (AAE) consensus motif; other site
546414007535	putative active site [active]
546414007536	AMP binding site [chemical binding]; other site
546414007537	putative CoA binding site [chemical binding]; other site
546414007538	Domain of unknown function (DUF2382); Region: DUF2382; cl01590
546414007539	PRC-barrel domain; Region: PRC; pfam05239
546414007540	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3861
546414007541	cofactor-independent phosphoglycerate mutase; Provisional; Region: PRK04135
546414007542	cofactor-independent phosphoglycerate mutase; Provisional; Region: PRK04200
546414007543	integral membrane protein, YkoY family; Region: R_switched_YkoY; TIGR03716
546414007544	tRNA guanosine-2'-O-methyltransferase; Provisional; Region: PRK11081
546414007545	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
546414007546	SpoU, rRNA methylase, C-terminal; Region: SpoU_methylas_C; pfam12105
546414007547	nitrosocyanin; Region: nitroso_cyanin; TIGR03096
546414007548	Coproporphyrinogen III oxidase and related Fe-S oxidoreductases [Coenzyme metabolism]; Region: HemN; COG0635
546414007549	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
546414007550	FeS/SAM binding site; other site
546414007551	HemN C-terminal domain; Region: HemN_C; pfam06969
546414007552	dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416
546414007553	Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730
546414007554	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
546414007555	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
546414007556	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
546414007557	KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454
546414007558	substrate-cofactor binding pocket; other site
546414007559	pyridoxal 5'-phosphate binding site [chemical binding]; other site
546414007560	catalytic residue [active]
546414007561	Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226
546414007562	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
546414007563	S-adenosylmethionine binding site [chemical binding]; other site
546414007564	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
546414007565	DNA binding site [nucleotide binding]
546414007566	active site
546414007567	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
546414007568	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
546414007569	active site
546414007570	metal binding site [ion binding]; metal-binding site
546414007571	Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409
546414007572	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
546414007573	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
546414007574	Coenzyme A binding pocket [chemical binding]; other site
546414007575	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
546414007576	Coenzyme A binding pocket [chemical binding]; other site
546414007577	Peptidylarginine deiminase and related enzymes [Amino acid transport and metabolism]; Region: COG2957; cl01113
546414007578	Porphyromonas-type peptidyl-arginine deiminase; Region: PAD_porph; pfam04371
546414007579	This domain is the catalytic domain of ribonuclease II; Region: RNB; smart00955
546414007580	RNB domain; Region: RNB; pfam00773
546414007581	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3877
546414007582	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
546414007583	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
546414007584	Coenzyme A binding pocket [chemical binding]; other site
546414007585	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
546414007586	Beta-lactamase; Region: Beta-lactamase; pfam00144
546414007587	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
546414007588	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
546414007589	ligand binding site [chemical binding]; other site
546414007590	flexible hinge region; other site
546414007591	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
546414007592	putative switch regulator; other site
546414007593	non-specific DNA interactions [nucleotide binding]; other site
546414007594	DNA binding site [nucleotide binding]
546414007595	sequence specific DNA binding site [nucleotide binding]; other site
546414007596	putative cAMP binding site [chemical binding]; other site
546414007597	Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418
546414007598	acyl-CoA dehydrogenase; Provisional; Region: PTZ00456
546414007599	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
546414007600	active site
546414007601	Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806
546414007602	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
546414007603	DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972
546414007604	catalytic residues [active]
546414007605	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
546414007606	N-carbamoylputrescine amidohydrolase (CPA) (class 11 nitrilases); Region: CPA; cd07573
546414007607	N-carbamoylputrescine amidase; Region: agmatine_aguB; TIGR03381
546414007608	putative active site; other site
546414007609	catalytic triad [active]
546414007610	putative dimer interface [polypeptide binding]; other site
546414007611	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
546414007612	Cytochrome P450; Region: p450; cl12078
546414007613	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
546414007614	Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA; Region: PseudoU_synth_EcTruA; cd02570
546414007615	dimerization interface 3.5A [polypeptide binding]; other site
546414007616	active site
546414007617	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
546414007618	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
546414007619	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
546414007620	Peptidase family M23; Region: Peptidase_M23; pfam01551
546414007621	5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346
546414007622	Sugar-specific transcriptional regulator TrmB; Region: TrmB; cl17775
546414007623	Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897
546414007624	Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448
546414007625	active site residue [active]
546414007626	Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449
546414007627	active site residue [active]
546414007628	exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286
546414007629	ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489
546414007630	generic binding surface II; other site
546414007631	generic binding surface I; other site
546414007632	Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239
546414007633	CorA-like Mg2+ transporter protein; Region: CorA; pfam01544
546414007634	Thermotoga maritima CorA-like family; Region: TmCorA-like; cd12822
546414007635	oligomer interface [polypeptide binding]; other site
546414007636	metal binding site [ion binding]; metal-binding site
546414007637	metal binding site [ion binding]; metal-binding site
546414007638	putative Cl binding site [ion binding]; other site
546414007639	aspartate ring; other site
546414007640	basic sphincter; other site
546414007641	hydrophobic gate; other site
546414007642	periplasmic entrance; other site
546414007643	Protein of unknown function (DUF1228); Region: DUF1228; pfam06779
546414007644	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
546414007645	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209
546414007646	folate binding site [chemical binding]; other site
546414007647	NADP+ binding site [chemical binding]; other site
546414007648	Deoxycytidylate deaminase [Nucleotide transport and metabolism]; Region: ComEB; COG2131
546414007649	active site
546414007650	Zn binding site [ion binding]; other site
546414007651	thymidylate synthase; Reviewed; Region: thyA; PRK01827
546414007652	Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351
546414007653	dimerization interface [polypeptide binding]; other site
546414007654	active site
546414007655	fumarate hydratase; Reviewed; Region: fumC; PRK00485
546414007656	Class II fumarases; Region: Fumarase_classII; cd01362
546414007657	active site
546414007658	tetramer interface [polypeptide binding]; other site
546414007659	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
546414007660	acetyl-CoA synthetase; Provisional; Region: PRK00174
546414007661	acyl-activating enzyme (AAE) consensus motif; other site
546414007662	AMP binding site [chemical binding]; other site
546414007663	active site
546414007664	CoA binding site [chemical binding]; other site
546414007665	Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177
546414007666	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
546414007667	minor groove reading motif; other site
546414007668	helix-hairpin-helix signature motif; other site
546414007669	active site
546414007670	Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304
546414007671	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
546414007672	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
546414007673	putative active site [active]
546414007674	substrate binding site [chemical binding]; other site
546414007675	putative cosubstrate binding site; other site
546414007676	catalytic site [active]
546414007677	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
546414007678	substrate binding site [chemical binding]; other site
546414007679	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
546414007680	active site
546414007681	catalytic residues [active]
546414007682	metal binding site [ion binding]; metal-binding site
546414007683	TPR repeat; Region: TPR_11; pfam13414
546414007684	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
546414007685	TPR motif; other site
546414007686	binding surface
546414007687	TPR repeat; Region: TPR_11; pfam13414
546414007688	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
546414007689	binding surface
546414007690	TPR motif; other site
546414007691	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
546414007692	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
546414007693	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836
546414007694	TfoX C-terminal domain; Region: TfoX_C; pfam04994
546414007695	DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595
546414007696	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
546414007697	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
546414007698	DNA binding residues [nucleotide binding]
546414007699	Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312
546414007700	Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908
546414007701	putative ADP-ribose binding site [chemical binding]; other site
546414007702	putative active site [active]
546414007703	Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194
546414007704	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
546414007705	catalytic site [active]
546414007706	G-X2-G-X-G-K; other site
546414007707	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
546414007708	AsnC family; Region: AsnC_trans_reg; pfam01037
546414007709	Predicted ATPase or kinase [General function prediction only]; Region: COG0802
546414007710	acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180
546414007711	propionate/acetate kinase; Provisional; Region: PRK12379
546414007712	phosphate acetyltransferase; Reviewed; Region: PRK05632
546414007713	DRTGG domain; Region: DRTGG; pfam07085
546414007714	Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl17212
546414007715	RNase H is an endonuclease that cleaves the RNA strand of an RNA/DNA hybrid in a sequence non-specific manner; Region: RNase_H; cl14782
546414007716	active site
546414007717	RNA/DNA hybrid binding site [nucleotide binding]; other site
546414007718	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
546414007719	Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230
546414007720	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
546414007721	S-adenosylmethionine binding site [chemical binding]; other site
546414007722	Predicted permeases [General function prediction only]; Region: COG0795
546414007723	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
546414007724	Predicted permeases [General function prediction only]; Region: COG0795
546414007725	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
546414007726	GTP-binding protein Der; Reviewed; Region: PRK00093
546414007727	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
546414007728	G1 box; other site
546414007729	GTP/Mg2+ binding site [chemical binding]; other site
546414007730	Switch I region; other site
546414007731	G2 box; other site
546414007732	Switch II region; other site
546414007733	G3 box; other site
546414007734	G4 box; other site
546414007735	G5 box; other site
546414007736	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
546414007737	G1 box; other site
546414007738	GTP/Mg2+ binding site [chemical binding]; other site
546414007739	Switch I region; other site
546414007740	G2 box; other site
546414007741	G3 box; other site
546414007742	Switch II region; other site
546414007743	G4 box; other site
546414007744	G5 box; other site
546414007745	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
546414007746	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
546414007747	polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cl17457
546414007748	FtsH Extracellular; Region: FtsH_ext; pfam06480
546414007749	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
546414007750	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
546414007751	Walker A motif; other site
546414007752	ATP binding site [chemical binding]; other site
546414007753	Walker B motif; other site
546414007754	arginine finger; other site
546414007755	Peptidase family M41; Region: Peptidase_M41; pfam01434
546414007756	Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405
546414007757	active site
546414007758	Peptidase M55, D-aminopeptidase dipeptide-binding protein family; Region: DAP_dppA; cl01007
546414007759	Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170
546414007760	elongation factor G; Reviewed; Region: PRK12740
546414007761	G1 box; other site
546414007762	putative GEF interaction site [polypeptide binding]; other site
546414007763	GTP/Mg2+ binding site [chemical binding]; other site
546414007764	Switch I region; other site
546414007765	G2 box; other site
546414007766	G3 box; other site
546414007767	Switch II region; other site
546414007768	G4 box; other site
546414007769	G5 box; other site
546414007770	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
546414007771	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
546414007772	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
546414007773	Predicted kinase [General function prediction only]; Region: COG4639
546414007774	Bacillus subtilis PrpE and related proteins, metallophosphatase domain; Region: MPP_PrpE; cd07423
546414007775	bis(5'-nucleosyl)-tetraphosphatase PrpE; Provisional; Region: PRK13625
546414007776	active site
546414007777	metal binding site [ion binding]; metal-binding site
546414007778	putative bacillithiol system oxidoreductase, YpdA family; Region: Bthiol_YpdA; TIGR04018
546414007779	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
546414007780	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
546414007781	Uncharacterized vancomycin resistance protein [Defense mechanisms]; Region: COG2720
546414007782	VanW like protein; Region: VanW; pfam04294
546414007783	nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285
546414007784	ParB-like nuclease domain; Region: ParB; smart00470
546414007785	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
546414007786	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
546414007787	P-loop; other site
546414007788	Magnesium ion binding site [ion binding]; other site
546414007789	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
546414007790	Magnesium ion binding site [ion binding]; other site
546414007791	rRNA small subunit methyltransferase G; Region: GidB; pfam02527
546414007792	16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107
546414007793	tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192
546414007794	NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206
546414007795	GidA associated domain 3; Region: GIDA_assoc_3; pfam13932
546414007796	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
546414007797	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
546414007798	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
546414007799	catalytic residue [active]
546414007800	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071
546414007801	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
546414007802	TPP-binding site [chemical binding]; other site
546414007803	tetramer interface [polypeptide binding]; other site
546414007804	heterodimer interface [polypeptide binding]; other site
546414007805	phosphorylation loop region [posttranslational modification]
546414007806	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
546414007807	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
546414007808	alpha subunit interface [polypeptide binding]; other site
546414007809	TPP binding site [chemical binding]; other site
546414007810	heterodimer interface [polypeptide binding]; other site
546414007811	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
546414007812	branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856
546414007813	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
546414007814	E3 interaction surface; other site
546414007815	lipoyl attachment site [posttranslational modification]; other site
546414007816	e3 binding domain; Region: E3_binding; pfam02817
546414007817	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
546414007818	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
546414007819	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
546414007820	active site
546414007821	phosphorylation site [posttranslational modification]
546414007822	intermolecular recognition site; other site
546414007823	dimerization interface [polypeptide binding]; other site
546414007824	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
546414007825	DNA binding site [nucleotide binding]
546414007826	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
546414007827	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
546414007828	G-X-G motif; other site
546414007829	Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758
546414007830	DNA protecting protein DprA; Region: dprA; TIGR00732
546414007831	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
546414007832	NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370
546414007833	NAD(P) binding site [chemical binding]; other site
546414007834	active site
546414007835	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
546414007836	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
546414007837	P-loop; other site
546414007838	Magnesium ion binding site [ion binding]; other site
546414007839	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
546414007840	Magnesium ion binding site [ion binding]; other site
546414007841	nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285
546414007842	ParB-like nuclease domain; Region: ParB; smart00470
546414007843	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
546414007844	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
546414007845	NAD(P) binding site [chemical binding]; other site
546414007846	active site
546414007847	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
546414007848	hydroxyglutarate oxidase; Provisional; Region: PRK11728
546414007849	Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277
546414007850	ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776
546414007851	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
546414007852	ATP binding site [chemical binding]; other site
546414007853	Mg++ binding site [ion binding]; other site
546414007854	motif III; other site
546414007855	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
546414007856	nucleotide binding region [chemical binding]; other site
546414007857	ATP-binding site [chemical binding]; other site
546414007858	RNA recognition motif in Escherichia coli RNA helicase dbpA and similar proteins; Region: RRM_EcDbpA_like; cd12501
546414007859	putative RNA binding site [nucleotide binding]; other site
546414007860	Replication initiator protein A; Region: RPA; cl17860
546414007861	pH-dependent sodium/proton antiporter; Provisional; Region: nhaA; PRK14855
546414007862	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
546414007863	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
546414007864	putative active site [active]
546414007865	heme pocket [chemical binding]; other site
546414007866	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
546414007867	putative active site [active]
546414007868	heme pocket [chemical binding]; other site
546414007869	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
546414007870	GAF domain; Region: GAF; pfam01590
546414007871	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
546414007872	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
546414007873	metal binding site [ion binding]; metal-binding site
546414007874	active site
546414007875	I-site; other site
546414007876	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
546414007877	DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases.  They exists as monomers and homodimers; Region: NUC; cd00091
546414007878	DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892
546414007879	active site
546414007880	substrate binding site [chemical binding]; other site
546414007881	Mg2+ binding site [ion binding]; other site
546414007882	glycosyl hydrolase family 16; Region: Glyco_hydrolase_16; cl00218
546414007883	active site
546414007884	catalytic residues [active]
546414007885	5'-3' exonuclease; Region: 53EXOc; smart00475
546414007886	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
546414007887	active site
546414007888	metal binding site 1 [ion binding]; metal-binding site
546414007889	putative 5' ssDNA interaction site; other site
546414007890	metal binding site 3; metal-binding site
546414007891	metal binding site 2 [ion binding]; metal-binding site
546414007892	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
546414007893	putative DNA binding site [nucleotide binding]; other site
546414007894	putative metal binding site [ion binding]; other site
546414007895	Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363
546414007896	M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656
546414007897	oligomer interface [polypeptide binding]; other site
546414007898	active site
546414007899	metal binding site [ion binding]; metal-binding site
546414007900	Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508
546414007901	mercuric reductase; Validated; Region: PRK06370
546414007902	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
546414007903	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
546414007904	DNA polymerase elongation subunit (family B) [DNA replication, recombination, and repair]; Region: PolB; COG0417
546414007905	DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012
546414007906	active site
546414007907	catalytic site [active]
546414007908	substrate binding site [chemical binding]; other site
546414007909	DNA polymerase type-B family catalytic domain. DNA-directed DNA polymerases elongate DNA by adding nucleotide triphosphate (dNTP) residues to the 5'-end of the growing chain of DNA. DNA-directed DNA polymerases are multifunctional with both...; Region: POLBc; cl10023
546414007910	active site
546414007911	metal-binding site
546414007912	Response regulator receiver domain; Region: Response_reg; pfam00072
546414007913	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
546414007914	active site
546414007915	phosphorylation site [posttranslational modification]
546414007916	intermolecular recognition site; other site
546414007917	dimerization interface [polypeptide binding]; other site
546414007918	PAS domain S-box; Region: sensory_box; TIGR00229
546414007919	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
546414007920	putative active site [active]
546414007921	heme pocket [chemical binding]; other site
546414007922	PAS domain S-box; Region: sensory_box; TIGR00229
546414007923	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
546414007924	putative active site [active]
546414007925	heme pocket [chemical binding]; other site
546414007926	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
546414007927	GAF domain; Region: GAF; pfam01590
546414007928	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
546414007929	PAS fold; Region: PAS_3; pfam08447
546414007930	putative active site [active]
546414007931	heme pocket [chemical binding]; other site
546414007932	PAS fold; Region: PAS_3; pfam08447
546414007933	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
546414007934	putative active site [active]
546414007935	heme pocket [chemical binding]; other site
546414007936	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
546414007937	dimer interface [polypeptide binding]; other site
546414007938	phosphorylation site [posttranslational modification]
546414007939	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
546414007940	ATP binding site [chemical binding]; other site
546414007941	Mg2+ binding site [ion binding]; other site
546414007942	G-X-G motif; other site
546414007943	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
546414007944	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
546414007945	active site
546414007946	phosphorylation site [posttranslational modification]
546414007947	intermolecular recognition site; other site
546414007948	dimerization interface [polypeptide binding]; other site
546414007949	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
546414007950	RNA polymerase sigma factor RpoD, C-terminal domain; Region: RpoD_Cterm; TIGR02393
546414007951	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
546414007952	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
546414007953	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
546414007954	DNA binding residues [nucleotide binding]
546414007955	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
546414007956	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
546414007957	DNA-binding site [nucleotide binding]; DNA binding site
546414007958	UTRA domain; Region: UTRA; pfam07702
546414007959	PAS fold; Region: PAS_4; pfam08448
546414007960	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
546414007961	GAF domain; Region: GAF_2; pfam13185
546414007962	PAS domain S-box; Region: sensory_box; TIGR00229
546414007963	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
546414007964	putative active site [active]
546414007965	heme pocket [chemical binding]; other site
546414007966	PAS domain S-box; Region: sensory_box; TIGR00229
546414007967	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
546414007968	putative active site [active]
546414007969	heme pocket [chemical binding]; other site
546414007970	PAS domain S-box; Region: sensory_box; TIGR00229
546414007971	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
546414007972	putative active site [active]
546414007973	heme pocket [chemical binding]; other site
546414007974	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
546414007975	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
546414007976	dimer interface [polypeptide binding]; other site
546414007977	phosphorylation site [posttranslational modification]
546414007978	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
546414007979	ATP binding site [chemical binding]; other site
546414007980	Mg2+ binding site [ion binding]; other site
546414007981	G-X-G motif; other site
546414007982	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
546414007983	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
546414007984	metal binding site [ion binding]; metal-binding site
546414007985	active site
546414007986	I-site; other site
546414007987	Predicted ATPase [General function prediction only]; Region: COG3903
546414007988	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
546414007989	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
546414007990	DNA binding residues [nucleotide binding]
546414007991	dimerization interface [polypeptide binding]; other site
546414007992	NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956
546414007993	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
546414007994	nucleotide binding pocket [chemical binding]; other site
546414007995	K-X-D-G motif; other site
546414007996	catalytic site [active]
546414007997	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
546414007998	NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119
546414007999	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
546414008000	Dimer interface [polypeptide binding]; other site
546414008001	NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012
546414008002	Alpha-Ketoglutaric Semialdehyde Dehydrogenase; Region: ALDH_KGSADH; cd07129
546414008003	dimer interface [polypeptide binding]; other site
546414008004	NADP binding site [chemical binding]; other site
546414008005	catalytic residues [active]
546414008006	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
546414008007	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
546414008008	inhibitor site; inhibition site
546414008009	active site
546414008010	dimer interface [polypeptide binding]; other site
546414008011	catalytic residue [active]
546414008012	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992
546414008013	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510
546414008014	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
546414008015	hydroxyglutarate oxidase; Provisional; Region: PRK11728
546414008016	hydroxyproline-2-epimerase; Provisional; Region: PRK13970
546414008017	hydroxyproline-2-epimerase; Provisional; Region: PRK13971
546414008018	PAS fold; Region: PAS_4; pfam08448
546414008019	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
546414008020	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
546414008021	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
546414008022	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
546414008023	Transposase; Region: HTH_Tnp_1; pfam01527
546414008024	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
546414008025	putative transposase OrfB; Reviewed; Region: PHA02517
546414008026	HTH-like domain; Region: HTH_21; pfam13276
546414008027	Integrase core domain; Region: rve; pfam00665
546414008028	Integrase core domain; Region: rve_3; pfam13683
546414008029	cyanophycin synthetase; Provisional; Region: PRK14016
546414008030	ATP-grasp domain; Region: ATP-grasp_4; pfam13535
546414008031	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
546414008032	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
546414008033	serine racemase; Region: PLN02970
546414008034	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
546414008035	tetramer interface [polypeptide binding]; other site
546414008036	pyridoxal 5'-phosphate binding site [chemical binding]; other site
546414008037	catalytic residue [active]
546414008038	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
546414008039	homotrimer interaction site [polypeptide binding]; other site
546414008040	putative active site [active]
546414008041	RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278
546414008042	RNA/DNA hybrid binding site [nucleotide binding]; other site
546414008043	active site
546414008044	GAF domain; Region: GAF; pfam01590
546414008045	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
546414008046	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
546414008047	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
546414008048	metal binding site [ion binding]; metal-binding site
546414008049	active site
546414008050	I-site; other site
546414008051	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
546414008052	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
546414008053	PAS domain; Region: PAS_9; pfam13426
546414008054	putative active site [active]
546414008055	heme pocket [chemical binding]; other site
546414008056	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
546414008057	ATP binding site [chemical binding]; other site
546414008058	Mg2+ binding site [ion binding]; other site
546414008059	G-X-G motif; other site
546414008060	Chemotaxis response regulator containing a CheY-like receiver domain and a methylesterase domain [Cell motility and secretion / Signal transduction mechanisms]; Region: CheB; COG2201
546414008061	CheB methylesterase; Region: CheB_methylest; pfam01339
546414008062	DsrE/DsrF/DrsH-like family; Region: DrsE_2; cl17453
546414008063	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
546414008064	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
546414008065	active site
546414008066	catalytic tetrad [active]
546414008067	Putative catalytic NodB homology domain of uncharacterized prokaryotic polysaccharide deacetylases which consist of a 6-stranded beta/alpha barrel; Region: CE4_DAC_u1_6s; cd10970
546414008068	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
546414008069	putative active site [active]
546414008070	putative metal binding site [ion binding]; other site
546414008071	Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853
546414008072	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
546414008073	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
546414008074	active site
546414008075	phosphorylation site [posttranslational modification]
546414008076	intermolecular recognition site; other site
546414008077	dimerization interface [polypeptide binding]; other site
546414008078	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
546414008079	DNA binding site [nucleotide binding]
546414008080	Alpha-mannosidase [Carbohydrate transport and metabolism]; Region: AMS1; COG0383
546414008081	N-terminal catalytic domain of endoplasmic reticulum(ER)/cytosolic class II alpha-mannosidases; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_ER_cytosolic; cd10789
546414008082	active site
546414008083	catalytic site [active]
546414008084	Alpha mannosidase, middle domain; Region: Alpha-mann_mid; pfam09261
546414008085	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
546414008086	binding surface
546414008087	TPR motif; other site
546414008088	Tetratricopeptide repeat; Region: TPR_12; pfam13424
546414008089	Bacterial transcriptional activator domain; Region: BTAD; smart01043
546414008090	S-formylglutathione hydrolase; Region: PLN02442
546414008091	Predicted membrane protein [Function unknown]; Region: COG2862
546414008092	Integral membrane protein TerC family; Region: TerC; cl10468
546414008093	Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647
546414008094	active site
546414008095	Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161
546414008096	Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652
546414008097	putative sugar binding sites [chemical binding]; other site
546414008098	Q-X-W motif; other site
546414008099	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
546414008100	pfkB family carbohydrate kinase; Region: PfkB; pfam00294
546414008101	substrate binding site [chemical binding]; other site
546414008102	ATP binding site [chemical binding]; other site
546414008103	Uncharacterized proteins, LmbE homologs [Function unknown]; Region: COG2120
546414008104	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
546414008105	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
546414008106	dimer interface [polypeptide binding]; other site
546414008107	conserved gate region; other site
546414008108	putative PBP binding loops; other site
546414008109	ABC-ATPase subunit interface; other site
546414008110	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
546414008111	dimer interface [polypeptide binding]; other site
546414008112	conserved gate region; other site
546414008113	putative PBP binding loops; other site
546414008114	ABC-ATPase subunit interface; other site
546414008115	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
546414008116	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
546414008117	Argininosuccinate lyase [Amino acid transport and metabolism]; Region: ArgH; COG0165
546414008118	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
546414008119	active sites [active]
546414008120	tetramer interface [polypeptide binding]; other site
546414008121	Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412
546414008122	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
546414008123	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
546414008124	Suppressor of fused protein (SUFU); Region: SUFU; pfam05076
546414008125	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
546414008126	Uncharacterized conserved protein [Function unknown]; Region: COG2128
546414008127	pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613
546414008128	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
546414008129	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
546414008130	active site
546414008131	catalytic residues [active]
546414008132	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
546414008133	active site
546414008134	catalytic residues [active]
546414008135	Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032
546414008136	Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305
546414008137	E-class dimer interface [polypeptide binding]; other site
546414008138	P-class dimer interface [polypeptide binding]; other site
546414008139	active site
546414008140	Cu2+ binding site [ion binding]; other site
546414008141	Zn2+ binding site [ion binding]; other site
546414008142	SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450
546414008143	Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133
546414008144	dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606
546414008145	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
546414008146	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
546414008147	Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996
546414008148	substrate binding [chemical binding]; other site
546414008149	active site
546414008150	Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244
546414008151	luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558
546414008152	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
546414008153	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
546414008154	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
546414008155	metal binding site [ion binding]; metal-binding site
546414008156	active site
546414008157	I-site; other site
546414008158	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
546414008159	PAS domain S-box; Region: sensory_box; TIGR00229
546414008160	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
546414008161	putative active site [active]
546414008162	heme pocket [chemical binding]; other site
546414008163	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
546414008164	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
546414008165	metal binding site [ion binding]; metal-binding site
546414008166	active site
546414008167	I-site; other site
546414008168	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
546414008169	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
546414008170	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
546414008171	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833
546414008172	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
546414008173	Intradiol dioxygenase supgroup. Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. They break the catechol C1-C2 bond and utilize Fe3+, as opposed to  the...; Region: intradiol_dioxygenase_like; cd03457
546414008174	putative active site [active]
546414008175	Protein of unknown function (DUF3060); Region: DUF3060; pfam11259
546414008176	A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cl00279
546414008177	active site
546414008178	Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171
546414008179	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
546414008180	tetramer interface [polypeptide binding]; other site
546414008181	pyridoxal 5'-phosphate binding site [chemical binding]; other site
546414008182	catalytic residue [active]
546414008183	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
546414008184	homotrimer interaction site [polypeptide binding]; other site
546414008185	putative active site [active]
546414008186	heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386
546414008187	HAMP domain; Region: HAMP; pfam00672
546414008188	dimerization interface [polypeptide binding]; other site
546414008189	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
546414008190	dimer interface [polypeptide binding]; other site
546414008191	phosphorylation site [posttranslational modification]
546414008192	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
546414008193	ATP binding site [chemical binding]; other site
546414008194	Mg2+ binding site [ion binding]; other site
546414008195	G-X-G motif; other site
546414008196	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
546414008197	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
546414008198	active site
546414008199	phosphorylation site [posttranslational modification]
546414008200	intermolecular recognition site; other site
546414008201	dimerization interface [polypeptide binding]; other site
546414008202	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
546414008203	DNA binding site [nucleotide binding]
546414008204	Domain of unknown function (DUF4397); Region: DUF4397; pfam14344
546414008205	Response regulator receiver domain; Region: Response_reg; pfam00072
546414008206	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
546414008207	active site
546414008208	phosphorylation site [posttranslational modification]
546414008209	intermolecular recognition site; other site
546414008210	dimerization interface [polypeptide binding]; other site
546414008211	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
546414008212	cheY-homologous receiver domain; Region: REC; smart00448
546414008213	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
546414008214	DNA binding site [nucleotide binding]
546414008215	Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967
546414008216	nucleotidyl binding site; other site
546414008217	metal binding site [ion binding]; metal-binding site
546414008218	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
546414008219	active site
546414008220	catalytic residues [active]
546414008221	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
546414008222	active site
546414008223	catalytic residues [active]
546414008224	FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457
546414008225	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
546414008226	binding surface
546414008227	TPR motif; other site
546414008228	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
546414008229	binding surface
546414008230	TPR motif; other site
546414008231	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
546414008232	Zn2+ binding site [ion binding]; other site
546414008233	Mg2+ binding site [ion binding]; other site
546414008234	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
546414008235	binding surface
546414008236	TPR motif; other site
546414008237	Tetratricopeptide repeat; Region: TPR_12; pfam13424
546414008238	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
546414008239	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
546414008240	metal binding site [ion binding]; metal-binding site
546414008241	active site
546414008242	I-site; other site
546414008243	Uncharacterized conserved protein [Function unknown]; Region: COG0397
546414008244	hypothetical protein; Validated; Region: PRK00029
546414008245	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
546414008246	This novel putative carbohydrate binding module (NPCBM) domain is found at the N-terminus of glycosyl hydrolase family 98 proteins; Region: NPCBM; smart00776
546414008247	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
546414008248	active site residue [active]
546414008249	Electron transfer DM13; Region: DM13; cl02735
546414008250	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
546414008251	Peptidase family M23; Region: Peptidase_M23; pfam01551
546414008252	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
546414008253	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
546414008254	Coenzyme A binding pocket [chemical binding]; other site
546414008255	2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654
546414008256	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
546414008257	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
546414008258	DNA binding site [nucleotide binding]
546414008259	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
546414008260	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
546414008261	active site
546414008262	phosphorylation site [posttranslational modification]
546414008263	intermolecular recognition site; other site
546414008264	dimerization interface [polypeptide binding]; other site
546414008265	Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041
546414008266	Oxidoreductase molybdopterin binding domain; Region: Oxidored_molyb; pfam00174
546414008267	Moco binding site; other site
546414008268	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
546414008269	putative substrate translocation pore; other site
546414008270	Major Facilitator Superfamily; Region: MFS_1; pfam07690
546414008271	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
546414008272	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cl00257
546414008273	IHF - DNA interface [nucleotide binding]; other site
546414008274	nitrous oxide reductase family maturation protein NosD; Region: NosD_copper_fam; TIGR04247
546414008275	Uncharacterized BCR, COG1649; Region: DUF187; pfam02638
546414008276	Beta-eliminating lyase; Region: Beta_elim_lyase; pfam01212
546414008277	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
546414008278	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
546414008279	catalytic residue [active]
546414008280	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
546414008281	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
546414008282	Amidohydrolase; Region: Amidohydro_2; pfam04909
546414008283	active site
546414008284	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
546414008285	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
546414008286	active site
546414008287	Int/Topo IB signature motif; other site
546414008288	catalytic residues [active]
546414008289	DNA binding site [nucleotide binding]
546414008290	AAA domain; Region: AAA_33; pfam13671
546414008291	AAA domain; Region: AAA_17; pfam13207
546414008292	TIGR02569 family protein; Region: TIGR02569_actnb
546414008293	Uncharacterized conserved protein [Function unknown]; Region: COG3268
546414008294	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
546414008295	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
546414008296	renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301
546414008297	dimer interface [polypeptide binding]; other site
546414008298	Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355
546414008299	active site
546414008300	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
546414008301	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
546414008302	dimer interface [polypeptide binding]; other site
546414008303	conserved gate region; other site
546414008304	putative PBP binding loops; other site
546414008305	ABC-ATPase subunit interface; other site
546414008306	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
546414008307	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
546414008308	ABC-ATPase subunit interface; other site
546414008309	putative PBP binding loops; other site
546414008310	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
546414008311	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_19; cd08518
546414008312	PA domain; Region: PA; pfam02225
546414008313	PA/protease or protease-like domain interface [polypeptide binding]; other site
546414008314	M28 Zn-peptidases include aminopeptidases and carboxypeptidases; Region: M28; cd02690
546414008315	Peptidase family M28; Region: Peptidase_M28; pfam04389
546414008316	metal binding site [ion binding]; metal-binding site
546414008317	IclR helix-turn-helix domain; Region: HTH_IclR; cl17605
546414008318	Transcriptional regulator [Transcription]; Region: IclR; COG1414
546414008319	Bacterial transcriptional regulator; Region: IclR; pfam01614
546414008320	glycosyl hydrolase family 16; Region: Glyco_hydrolase_16; cl00218
546414008321	active site
546414008322	catalytic residues [active]
546414008323	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
546414008324	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
546414008325	active site
546414008326	phosphorylation site [posttranslational modification]
546414008327	intermolecular recognition site; other site
546414008328	dimerization interface [polypeptide binding]; other site
546414008329	recombinase A; Provisional; Region: recA; PRK09354
546414008330	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
546414008331	hexamer interface [polypeptide binding]; other site
546414008332	Walker A motif; other site
546414008333	ATP binding site [chemical binding]; other site
546414008334	Walker B motif; other site
546414008335	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
546414008336	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
546414008337	metal binding site [ion binding]; metal-binding site
546414008338	active site
546414008339	I-site; other site
546414008340	Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514
546414008341	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
546414008342	ATP binding site [chemical binding]; other site
546414008343	putative Mg++ binding site [ion binding]; other site
546414008344	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
546414008345	nucleotide binding region [chemical binding]; other site
546414008346	ATP-binding site [chemical binding]; other site
546414008347	IclR helix-turn-helix domain; Region: HTH_IclR; cl17605
546414008348	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
546414008349	Glycerophosphodiester phosphodiesterase domain of putative Agrobacterium tumefaciens glycerophosphodiester phosphodiesterase and similar proteins; Region: GDPD_pAtGDE_like; cd08565
546414008350	active site
546414008351	catalytic site [active]
546414008352	metal binding site [ion binding]; metal-binding site
546414008353	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
546414008354	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
546414008355	putative dimer interface [polypeptide binding]; other site
546414008356	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
546414008357	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
546414008358	protein binding site [polypeptide binding]; other site
546414008359	Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism]; Region: COG4670
546414008360	Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788
546414008361	3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428
546414008362	putative acyltransferase; Provisional; Region: PRK05790
546414008363	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
546414008364	dimer interface [polypeptide binding]; other site
546414008365	active site
546414008366	prokaryotic 3-carboxy-cis,cis-muconate cycloisomerase (CMLE)_like; Region: pCLME; cd01597
546414008367	Adenylosuccinate lyase [Nucleotide transport and metabolism]; Region: PurB; COG0015
546414008368	tetramer interface [polypeptide binding]; other site
546414008369	active site
546414008370	Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl17208
546414008371	active site
546414008372	Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl17208
546414008373	protocatechuate 3,4-dioxygenase, beta subunit; Region: protocat_beta; TIGR02422
546414008374	active site
546414008375	3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427
546414008376	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
546414008377	Carboxymuconolactone decarboxylase family; Region: CMD; cl00460
546414008378	Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466
546414008379	Dehydroquinase class II; Region: DHquinase_II; pfam01220
546414008380	active site
546414008381	trimer interface [polypeptide binding]; other site
546414008382	dimer interface [polypeptide binding]; other site
546414008383	Pectate lyase; Region: Pec_lyase_C; cl01593
546414008384	Right handed beta helix region; Region: Beta_helix; pfam13229
546414008385	Right handed beta helix region; Region: Beta_helix; pfam13229
546414008386	IclR helix-turn-helix domain; Region: HTH_IclR; cl17605
546414008387	Transcriptional regulator [Transcription]; Region: IclR; COG1414
546414008388	Bacterial transcriptional regulator; Region: IclR; pfam01614
546414008389	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
546414008390	4-hydroxyphenylpyruvate dioxygenase and related hemolysins [Amino acid transport and metabolism / General function prediction only]; Region: COG3185
546414008391	N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342
546414008392	dimer interface [polypeptide binding]; other site
546414008393	C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250
546414008394	active site
546414008395	Fe binding site [ion binding]; other site
546414008396	shikimate 5-dehydrogenase; Reviewed; Region: PRK12549
546414008397	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
546414008398	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
546414008399	shikimate binding site; other site
546414008400	NAD(P) binding site [chemical binding]; other site
546414008401	beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431
546414008402	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
546414008403	Bacterial transcriptional regulator; Region: IclR; pfam01614
546414008404	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181
546414008405	Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331
546414008406	Tripartite tricarboxylate transporter TctA family; Region: TctA; pfam01970
546414008407	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
546414008408	Domain of unknown function DUF20; Region: UPF0118; pfam01594
546414008409	Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637
546414008410	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
546414008411	motif II; other site
546414008412	Transcriptional regulators [Transcription]; Region: FadR; COG2186
546414008413	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
546414008414	DNA-binding site [nucleotide binding]; DNA binding site
546414008415	FCD domain; Region: FCD; pfam07729
546414008416	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
546414008417	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_5; cd08511
546414008418	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
546414008419	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
546414008420	dimer interface [polypeptide binding]; other site
546414008421	conserved gate region; other site
546414008422	putative PBP binding loops; other site
546414008423	ABC-ATPase subunit interface; other site
546414008424	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
546414008425	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
546414008426	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
546414008427	dimer interface [polypeptide binding]; other site
546414008428	conserved gate region; other site
546414008429	putative PBP binding loops; other site
546414008430	ABC-ATPase subunit interface; other site
546414008431	Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405
546414008432	Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019
546414008433	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
546414008434	Predicted acetamidase/formamidase [Energy production and conversion]; Region: COG2421
546414008435	Carboxypeptidase C (cathepsin A) [Amino acid transport and metabolism]; Region: COG2939
546414008436	Serine carboxypeptidase; Region: Peptidase_S10; cl08270
546414008437	sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022
546414008438	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
546414008439	Esterase PHB depolymerase; Region: Esterase_phd; pfam10503
546414008440	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
546414008441	Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333
546414008442	amphipathic channel; other site
546414008443	Asn-Pro-Ala signature motifs; other site
546414008444	polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cl17457
546414008445	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
546414008446	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
546414008447	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
546414008448	putative active site [active]
546414008449	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
546414008450	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
546414008451	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
546414008452	dimer interface [polypeptide binding]; other site
546414008453	conserved gate region; other site
546414008454	putative PBP binding loops; other site
546414008455	ABC-ATPase subunit interface; other site
546414008456	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
546414008457	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
546414008458	dimer interface [polypeptide binding]; other site
546414008459	conserved gate region; other site
546414008460	putative PBP binding loops; other site
546414008461	ABC-ATPase subunit interface; other site
546414008462	Gluconate kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770
546414008463	Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070
546414008464	N- and C-terminal domain interface [polypeptide binding]; other site
546414008465	active site
546414008466	catalytic site [active]
546414008467	metal binding site [ion binding]; metal-binding site
546414008468	carbohydrate binding site [chemical binding]; other site
546414008469	ATP binding site [chemical binding]; other site
546414008470	2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800
546414008471	KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452
546414008472	active site
546414008473	intersubunit interface [polypeptide binding]; other site
546414008474	catalytic residue [active]
546414008475	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
546414008476	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
546414008477	substrate binding site [chemical binding]; other site
546414008478	ATP binding site [chemical binding]; other site
546414008479	mannonate dehydratase; Provisional; Region: PRK03906
546414008480	mannonate dehydratase; Region: uxuA; TIGR00695
546414008481	2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800
546414008482	KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452
546414008483	active site
546414008484	intersubunit interface [polypeptide binding]; other site
546414008485	catalytic residue [active]
546414008486	galactonate dehydratase; Provisional; Region: PRK14017
546414008487	D-galactonate dehydratase catalyses the dehydration of galactonate to 2-keto-3-deoxygalactnate (KDGal), as part of the D-galactonate nonphosphorolytic catabolic Entner-Doudoroff pathway. D-galactonate dehydratase belongs to the enolase superfamily of...; Region: D-galactonate_dehydratase; cd03325
546414008488	putative active site pocket [active]
546414008489	putative metal binding site [ion binding]; other site
546414008490	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
546414008491	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
546414008492	metal-binding site [ion binding]
546414008493	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
546414008494	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
546414008495	metal-binding site [ion binding]
546414008496	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
546414008497	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
546414008498	motif II; other site
546414008499	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
546414008500	metal-binding site [ion binding]
546414008501	Thermus thermophilus CsoR, a Cu(I)-sensing transcriptional regulator, and related domains; this domain family was previously known as part of DUF156; Region: TthCsoR-like_DUF156; cd10151
546414008502	putative homodimer interface [polypeptide binding]; other site
546414008503	putative homotetramer interface [polypeptide binding]; other site
546414008504	allosteric switch controlling residues; other site
546414008505	putative metal binding site [ion binding]; other site
546414008506	putative homodimer-homodimer interface [polypeptide binding]; other site
546414008507	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
546414008508	Putative glycerate kinase [Carbohydrate transport and metabolism]; Region: GckA; COG2379
546414008509	Domain of unknown function (DUF4147); Region: DUF4147; pfam13660
546414008510	MOFRL family; Region: MOFRL; pfam05161
546414008511	Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059
546414008512	chromate transporter, chromate ion transporter (CHR) family; Region: 2A51; TIGR00937
546414008513	Chromate transporter; Region: Chromate_transp; pfam02417
546414008514	Protein of unknown function (DUF3179); Region: DUF3179; pfam11376
546414008515	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
546414008516	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
546414008517	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
546414008518	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
546414008519	MarR family; Region: MarR; pfam01047
546414008520	GAF domain; Region: GAF; pfam01590
546414008521	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
546414008522	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
546414008523	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
546414008524	metal binding site [ion binding]; metal-binding site
546414008525	active site
546414008526	I-site; other site
546414008527	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
546414008528	Ligand Binding Site [chemical binding]; other site
546414008529	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
546414008530	Ligand Binding Site [chemical binding]; other site
546414008531	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4627
546414008532	succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK08651
546414008533	M20 Peptidases with similarity to acetylornithine deacetylases and succinyl-diaminopimelate desuccinylases; Region: M20_ArgE_DapE_like3; cd08013
546414008534	metal binding site [ion binding]; metal-binding site
546414008535	putative dimer interface [polypeptide binding]; other site
546414008536	Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342
546414008537	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
546414008538	catalytic residue [active]
546414008539	Replication initiator protein A; Region: RPA; cl17860
546414008540	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
546414008541	Putative catalytic NodB homology domain of uncharacterized prokaryotic polysaccharide deacetylases which consist of a 6-stranded beta/alpha barrel; Region: CE4_DAC_u1_6s; cd10970
546414008542	putative active site [active]
546414008543	putative metal binding site [ion binding]; other site
546414008544	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
546414008545	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
546414008546	Uncharacterized conserved protein [Function unknown]; Region: COG2308
546414008547	A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168
546414008548	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307
546414008549	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
546414008550	Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379
546414008551	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
546414008552	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
546414008553	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
546414008554	active site
546414008555	phosphorylation site [posttranslational modification]
546414008556	intermolecular recognition site; other site
546414008557	SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974
546414008558	Winged helix DNA-binding domain; Region: HTH_27; pfam13463
546414008559	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
546414008560	Catalytic site [active]
546414008561	Y-family of DNA polymerases; Region: PolY; cl12025
546414008562	active site
546414008563	DNA binding site [nucleotide binding]
546414008564	DNA polymerase III, alpha subunit [DNA replication, recombination, and repair]; Region: DnaE; COG0587
546414008565	Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102
546414008566	active site
546414008567	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
546414008568	generic binding surface I; other site
546414008569	generic binding surface II; other site
546414008570	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
546414008571	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
546414008572	active site
546414008573	catalytic tetrad [active]
546414008574	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
546414008575	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
546414008576	P-loop; other site
546414008577	Magnesium ion binding site [ion binding]; other site
546414008578	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
546414008579	Magnesium ion binding site [ion binding]; other site
546414008580	nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285
546414008581	ParB-like nuclease domain; Region: ParBc; pfam02195
546414008582	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
546414008583	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
546414008584	putative active site [active]
546414008585	heme pocket [chemical binding]; other site
546414008586	PAS domain; Region: PAS; smart00091
546414008587	PAS domain S-box; Region: sensory_box; TIGR00229
546414008588	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
546414008589	putative active site [active]
546414008590	heme pocket [chemical binding]; other site
546414008591	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
546414008592	dimer interface [polypeptide binding]; other site
546414008593	phosphorylation site [posttranslational modification]
546414008594	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
546414008595	ATP binding site [chemical binding]; other site
546414008596	Mg2+ binding site [ion binding]; other site
546414008597	G-X-G motif; other site
546414008598	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
546414008599	Beta-lactamase; Region: Beta-lactamase; pfam00144
546414008600	Aminoglycoside-2''-adenylyltransferase; Region: Aminoglyc_resit; pfam10706
546414008601	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
546414008602	IHF - DNA interface [nucleotide binding]; other site
546414008603	IHF dimer interface [polypeptide binding]; other site
546414008604	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3558
546414008605	SnoaL-like domain; Region: SnoaL_2; pfam12680
546414008606	Transcriptional regulators [Transcription]; Region: FadR; COG2186
546414008607	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
546414008608	DNA-binding site [nucleotide binding]; DNA binding site
546414008609	FCD domain; Region: FCD; pfam07729
546414008610	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
546414008611	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
546414008612	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
546414008613	dimer interface [polypeptide binding]; other site
546414008614	conserved gate region; other site
546414008615	putative PBP binding loops; other site
546414008616	ABC-ATPase subunit interface; other site
546414008617	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
546414008618	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
546414008619	dimer interface [polypeptide binding]; other site
546414008620	conserved gate region; other site
546414008621	putative PBP binding loops; other site
546414008622	ABC-ATPase subunit interface; other site
546414008623	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
546414008624	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
546414008625	inhibitor site; inhibition site
546414008626	active site
546414008627	dimer interface [polypeptide binding]; other site
546414008628	catalytic residue [active]
546414008629	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
546414008630	Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174
546414008631	substrate binding site [chemical binding]; other site
546414008632	dimer interface [polypeptide binding]; other site
546414008633	ATP binding site [chemical binding]; other site
546414008634	L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cl00947
546414008635	hexamer (dimer of trimers) interface [polypeptide binding]; other site
546414008636	trimer interface [polypeptide binding]; other site
546414008637	substrate binding site [chemical binding]; other site
546414008638	Mn binding site [ion binding]; other site
546414008639	uncharacterized xylulose kinase-like proteins; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_XK_like_1; cd07804
546414008640	Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070
546414008641	N- and C-terminal domain interface [polypeptide binding]; other site
546414008642	putative active site [active]
546414008643	MgATP binding site [chemical binding]; other site
546414008644	catalytic site [active]
546414008645	metal binding site [ion binding]; metal-binding site
546414008646	putative xylulose binding site [chemical binding]; other site
546414008647	putative homodimer interface [polypeptide binding]; other site
546414008648	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
546414008649	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
546414008650	substrate binding pocket [chemical binding]; other site
546414008651	membrane-bound complex binding site; other site
546414008652	hinge residues; other site
546414008653	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
546414008654	S-adenosylmethionine binding site [chemical binding]; other site
546414008655	PAS domain S-box; Region: sensory_box; TIGR00229
546414008656	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
546414008657	putative active site [active]
546414008658	heme pocket [chemical binding]; other site
546414008659	PAS domain S-box; Region: sensory_box; TIGR00229
546414008660	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
546414008661	putative active site [active]
546414008662	heme pocket [chemical binding]; other site
546414008663	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
546414008664	GAF domain; Region: GAF_3; pfam13492
546414008665	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
546414008666	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
546414008667	metal binding site [ion binding]; metal-binding site
546414008668	active site
546414008669	I-site; other site
546414008670	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
546414008671	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
546414008672	DNA-binding site [nucleotide binding]; DNA binding site
546414008673	UTRA domain; Region: UTRA; pfam07702
546414008674	Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222
546414008675	SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389
546414008676	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
546414008677	dimer interface [polypeptide binding]; other site
546414008678	active site
546414008679	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
546414008680	ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192
546414008681	substrate binding site [chemical binding]; other site
546414008682	ATP binding site [chemical binding]; other site
546414008683	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
546414008684	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
546414008685	substrate binding pocket [chemical binding]; other site
546414008686	membrane-bound complex binding site; other site
546414008687	hinge residues; other site
546414008688	recombinase A; Provisional; Region: recA; PRK09354
546414008689	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
546414008690	hexamer interface [polypeptide binding]; other site
546414008691	Walker A motif; other site
546414008692	ATP binding site [chemical binding]; other site
546414008693	Walker B motif; other site
546414008694	Sulfatase; Region: Sulfatase; cl17466
546414008695	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
546414008696	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
546414008697	putative trimer interface [polypeptide binding]; other site
546414008698	putative CoA binding site [chemical binding]; other site
546414008699	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
546414008700	putative trimer interface [polypeptide binding]; other site
546414008701	putative CoA binding site [chemical binding]; other site
546414008702	N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653
546414008703	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
546414008704	active site
546414008705	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
546414008706	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
546414008707	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
546414008708	Uncharacterized conserved protein [Function unknown]; Region: COG1359
546414008709	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
546414008710	PAS fold; Region: PAS_3; pfam08447
546414008711	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
546414008712	putative active site [active]
546414008713	heme pocket [chemical binding]; other site
546414008714	PAS domain; Region: PAS; smart00091
546414008715	PAS fold; Region: PAS_4; pfam08448
546414008716	PAS domain S-box; Region: sensory_box; TIGR00229
546414008717	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
546414008718	putative active site [active]
546414008719	heme pocket [chemical binding]; other site
546414008720	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
546414008721	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
546414008722	active site
546414008723	I-site; other site
546414008724	metal binding site [ion binding]; metal-binding site
546414008725	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
546414008726	GAF domain; Region: GAF_2; pfam13185
546414008727	GAF domain; Region: GAF_3; pfam13492
546414008728	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
546414008729	Zn2+ binding site [ion binding]; other site
546414008730	Mg2+ binding site [ion binding]; other site
546414008731	Peptidase S8 family domain, uncharacterized subfamily 12; Region: Peptidases_S8_12; cd07480
546414008732	active site
546414008733	catalytic triad [active]
546414008734	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
546414008735	Ligand Binding Site [chemical binding]; other site
546414008736	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
546414008737	Ligand Binding Site [chemical binding]; other site
546414008738	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
546414008739	MarR family; Region: MarR; pfam01047
546414008740	MarR family; Region: MarR_2; cl17246
546414008741	Protein of unknown function, DUF606; Region: DUF606; pfam04657
546414008742	Protein of unknown function, DUF606; Region: DUF606; pfam04657
546414008743	Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cl11399
546414008744	catalytic core [active]
546414008745	CYTH-like Clostridium thermocellum TTM-like subgroup 1; Region: CYTH-like_CthTTM-like_1; cd07891
546414008746	putative active site [active]
546414008747	putative metal binding residues [ion binding]; other site
546414008748	signature motif; other site
546414008749	putative dimer interface [polypeptide binding]; other site
546414008750	putative phosphate binding site [ion binding]; other site
546414008751	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
546414008752	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
546414008753	dimer interface [polypeptide binding]; other site
546414008754	pyridoxal 5'-phosphate binding site [chemical binding]; other site
546414008755	catalytic residue [active]
546414008756	SnoaL-like domain; Region: SnoaL_2; pfam12680
546414008757	dimethyl sulfone monooxygenase SfnG; Region: LLM_DMSO2_sfnG; TIGR04021
546414008758	Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094
546414008759	active site
546414008760	dimer interface [polypeptide binding]; other site
546414008761	non-prolyl cis peptide bond; other site
546414008762	insertion regions; other site
546414008763	ATP-grasp domain; Region: ATP-grasp_4; pfam13535
546414008764	aspartate racemase; Region: asp_race; TIGR00035
546414008765	Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518
546414008766	D-cysteine desulfhydrase; Validated; Region: PRK03910
546414008767	Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342
546414008768	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
546414008769	catalytic residue [active]
546414008770	DDE superfamily endonuclease; Region: DDE_3; pfam13358
546414008771	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
546414008772	DDE superfamily endonuclease; Region: DDE_3; pfam13358
546414008773	DinB superfamily; Region: DinB_2; pfam12867
546414008774	Prokaryotic phospholipase A2; Region: Phospholip_A2_3; pfam09056
546414008775	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
546414008776	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
546414008777	active site
546414008778	phosphorylation site [posttranslational modification]
546414008779	intermolecular recognition site; other site
546414008780	dimerization interface [polypeptide binding]; other site
546414008781	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
546414008782	active site
546414008783	phosphorylation site [posttranslational modification]
546414008784	intermolecular recognition site; other site
546414008785	Homoserine acetyltransferase [Amino acid transport and metabolism]; Region: MET2; COG2021
546414008786	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
546414008787	N-terminal catalytic domain of endoplasmic reticulum(ER)/cytosolic class II alpha-mannosidases; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_ER_cytosolic; cd10789
546414008788	Alpha-mannosidase [Carbohydrate transport and metabolism]; Region: AMS1; COG0383
546414008789	active site
546414008790	catalytic site [active]
546414008791	Alpha mannosidase, middle domain; Region: Alpha-mann_mid; smart00872
546414008792	Glycosyl hydrolases family 38 C-terminal domain; Region: Glyco_hydro_38C; pfam07748
546414008793	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
546414008794	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
546414008795	active site
546414008796	phosphorylation site [posttranslational modification]
546414008797	intermolecular recognition site; other site
546414008798	dimerization interface [polypeptide binding]; other site
546414008799	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
546414008800	DNA binding residues [nucleotide binding]
546414008801	dimerization interface [polypeptide binding]; other site
546414008802	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
546414008803	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
546414008804	dimer interface [polypeptide binding]; other site
546414008805	phosphorylation site [posttranslational modification]
546414008806	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
546414008807	ATP binding site [chemical binding]; other site
546414008808	Mg2+ binding site [ion binding]; other site
546414008809	G-X-G motif; other site
546414008810	Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168
546414008811	potassium uptake protein, TrkH family; Region: 2a38; TIGR00933
546414008812	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4634
546414008813	5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737
546414008814	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
546414008815	active site
546414008816	metal binding site [ion binding]; metal-binding site
546414008817	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
546414008818	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181
546414008819	tricarballylate dehydrogenase; Validated; Region: PRK08274
546414008820	Predicted oxidoreductase [General function prediction only]; Region: COG3573
546414008821	Transcriptional regulators [Transcription]; Region: GntR; COG1802
546414008822	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
546414008823	DNA-binding site [nucleotide binding]; DNA binding site
546414008824	FCD domain; Region: FCD; pfam07729
546414008825	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
546414008826	GAF domain; Region: GAF_2; pfam13185
546414008827	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
546414008828	GAF domain; Region: GAF_3; pfam13492
546414008829	GAF domain; Region: GAF_2; pfam13185
546414008830	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
546414008831	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
546414008832	putative active site [active]
546414008833	heme pocket [chemical binding]; other site
546414008834	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
546414008835	dimer interface [polypeptide binding]; other site
546414008836	phosphorylation site [posttranslational modification]
546414008837	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
546414008838	ATP binding site [chemical binding]; other site
546414008839	Mg2+ binding site [ion binding]; other site
546414008840	G-X-G motif; other site
546414008841	TMAO reductase sytem sensor TorS; Region: TMAO_torS; TIGR02956
546414008842	Major Facilitator Superfamily; Region: MFS_1; pfam07690
546414008843	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
546414008844	SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346
546414008845	DDE superfamily endonuclease; Region: DDE_5; pfam13546
546414008846	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565
546414008847	classical (c) SDRs; Region: SDR_c; cd05233
546414008848	NAD(P) binding site [chemical binding]; other site
546414008849	active site
546414008850	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
546414008851	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995
546414008852	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
546414008853	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
546414008854	dimer interface [polypeptide binding]; other site
546414008855	conserved gate region; other site
546414008856	putative PBP binding loops; other site
546414008857	ABC-ATPase subunit interface; other site
546414008858	nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790
546414008859	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
546414008860	dimer interface [polypeptide binding]; other site
546414008861	conserved gate region; other site
546414008862	Binding-protein-dependent transport system inner membrane component; Region: BPD_transp_1; pfam00528
546414008863	ABC-ATPase subunit interface; other site
546414008864	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
546414008865	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
546414008866	Walker A/P-loop; other site
546414008867	ATP binding site [chemical binding]; other site
546414008868	Q-loop/lid; other site
546414008869	ABC transporter signature motif; other site
546414008870	Walker B; other site
546414008871	D-loop; other site
546414008872	H-loop/switch region; other site
546414008873	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
546414008874	dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308
546414008875	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
546414008876	Walker A/P-loop; other site
546414008877	ATP binding site [chemical binding]; other site
546414008878	Q-loop/lid; other site
546414008879	ABC transporter signature motif; other site
546414008880	Walker B; other site
546414008881	D-loop; other site
546414008882	H-loop/switch region; other site
546414008883	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
546414008884	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
546414008885	DNA-binding site [nucleotide binding]; DNA binding site
546414008886	Creatinine amidohydrolase; Region: Creatininase; pfam02633
546414008887	Ketopantoate reductase [Coenzyme metabolism]; Region: ApbA; COG1893
546414008888	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
546414008889	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
546414008890	Demethylmenaquinone methyltransferase [Coenzyme metabolism]; Region: MenG; COG0684
546414008891	Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317
546414008892	Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460
546414008893	active site
546414008894	Zn binding site [ion binding]; other site
546414008895	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
546414008896	clavulanic acid dehydrogenase (CAD), classical (c) SDR; Region: CAD_SDR_c; cd08934
546414008897	NADP binding site [chemical binding]; other site
546414008898	homotetramer interface [polypeptide binding]; other site
546414008899	homodimer interface [polypeptide binding]; other site
546414008900	active site
546414008901	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
546414008902	Amidase; Region: Amidase; pfam01425
546414008903	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
546414008904	classical (c) SDRs; Region: SDR_c; cd05233
546414008905	NAD(P) binding site [chemical binding]; other site
546414008906	active site
546414008907	hypothetical protein; Provisional; Region: PRK08201
546414008908	Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_3; cd05680
546414008909	metal binding site [ion binding]; metal-binding site
546414008910	putative dimer interface [polypeptide binding]; other site
546414008911	M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393
546414008912	Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952
546414008913	active site
546414008914	Zn binding site [ion binding]; other site
546414008915	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
546414008916	Ankyrin repeats (many copies); Region: Ank_5; pfam13857
546414008917	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
546414008918	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_5; cd08511
546414008919	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
546414008920	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
546414008921	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
546414008922	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
546414008923	Amidohydrolase; Region: Amidohydro_2; pfam04909
546414008924	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
546414008925	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
546414008926	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
546414008927	Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412
546414008928	putative DNA binding site [nucleotide binding]; other site
546414008929	putative Zn2+ binding site [ion binding]; other site
546414008930	AsnC family; Region: AsnC_trans_reg; pfam01037
546414008931	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
546414008932	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995
546414008933	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
546414008934	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
546414008935	dimer interface [polypeptide binding]; other site
546414008936	conserved gate region; other site
546414008937	putative PBP binding loops; other site
546414008938	ABC-ATPase subunit interface; other site
546414008939	nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790
546414008940	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
546414008941	dimer interface [polypeptide binding]; other site
546414008942	conserved gate region; other site
546414008943	putative PBP binding loops; other site
546414008944	ABC-ATPase subunit interface; other site
546414008945	M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393
546414008946	active site
546414008947	Zn binding site [ion binding]; other site
546414008948	proline-specific peptidase, Bacillus coagulans-type subfamily; Region: pro_imino_pep_2; TIGR01250
546414008949	DDE superfamily endonuclease; Region: DDE_3; pfam13358
546414008950	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
546414008951	IHF - DNA interface [nucleotide binding]; other site
546414008952	IHF dimer interface [polypeptide binding]; other site
546414008953	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
546414008954	DNA-binding site [nucleotide binding]; DNA binding site
546414008955	RNA-binding motif; other site
546414008956	Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404
546414008957	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
546414008958	active site
546414008959	catalytic residues [active]
546414008960	PA: Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain; Region: PA; cl08238
546414008961	PA/protease or protease-like domain interface [polypeptide binding]; other site
546414008962	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
546414008963	catalytic residues [active]
546414008964	Uncharacterized membrane protein [Function unknown]; Region: COG5427; cl02250
546414008965	Homocysteine/selenocysteine methylase (S-methylmethionine-dependent) [Amino acid transport and metabolism]; Region: MHT1; COG2040
546414008966	Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574
546414008967	H+ Antiporter protein; Region: 2A0121; TIGR00900
546414008968	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
546414008969	Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917
546414008970	Barstar is an intracellular inhibitor of barnase, an extracellular ribonuclease of Bacillus amyloliquefaciens. Barstar binds tightly to the barnase active site and sterically blocks it, thus inhibiting its potentially lethal RNase activity inside the...; Region: Barstar_like; cl01048
546414008971	RNAase interaction site [polypeptide binding]; other site
546414008972	Domain of unknown function (DUF4172); Region: DUF4172; pfam13776
546414008973	Fic family protein [Function unknown]; Region: COG3177
546414008974	Fic/DOC family; Region: Fic; pfam02661
546414008975	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
546414008976	metal ion-dependent adhesion site (MIDAS); other site
546414008977	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
546414008978	Uncharacterized conserved protein [Function unknown]; Region: COG1262
546414008979	Predicted integral membrane protein (DUF2270); Region: DUF2270; cl02337
546414008980	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
546414008981	Sulfatase; Region: Sulfatase; pfam00884
546414008982	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
546414008983	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
546414008984	dimer interface [polypeptide binding]; other site
546414008985	conserved gate region; other site
546414008986	putative PBP binding loops; other site
546414008987	ABC-ATPase subunit interface; other site
546414008988	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
546414008989	dimer interface [polypeptide binding]; other site
546414008990	conserved gate region; other site
546414008991	putative PBP binding loops; other site
546414008992	ABC-ATPase subunit interface; other site
546414008993	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
546414008994	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
546414008995	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
546414008996	putative DNA binding site [nucleotide binding]; other site
546414008997	putative Zn2+ binding site [ion binding]; other site
546414008998	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
546414008999	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
546414009000	Protein of unknown function (DUF4242); Region: DUF4242; pfam14026
546414009001	Solo B3/4 domain (OB-fold DNA/RNA-binding) of Phe-aaRS-beta [General function prediction only]; Region: COG3382
546414009002	B3/4 domain; Region: B3_4; pfam03483
546414009003	Predicted flavin-nucleotide-binding protein [General function prediction only]; Region: COG3467
546414009004	putative acetyltransferase; Provisional; Region: PRK03624
546414009005	Myristoyl-CoA:protein N-myristoyltransferase, C-terminal domain; Region: NMT_C; pfam02799
546414009006	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
546414009007	Coenzyme A binding pocket [chemical binding]; other site
546414009008	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
546414009009	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
546414009010	DNA-binding site [nucleotide binding]; DNA binding site
546414009011	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
546414009012	pyridoxal 5'-phosphate binding site [chemical binding]; other site
546414009013	homodimer interface [polypeptide binding]; other site
546414009014	catalytic residue [active]
546414009015	Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222
546414009016	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
546414009017	dimer interface [polypeptide binding]; other site
546414009018	active site
546414009019	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
546414009020	dimer interface [polypeptide binding]; other site
546414009021	active site
546414009022	N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820
546414009023	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
546414009024	active site
546414009025	N-acetylmannosamine kinase; Provisional; Region: PRK05082
546414009026	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
546414009027	N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729
546414009028	N-acetylmannosamine-6-phosphate 2-epimerase; Provisional; Region: PRK01130
546414009029	putative active site cavity [active]
546414009030	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
546414009031	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
546414009032	inhibitor site; inhibition site
546414009033	active site
546414009034	dimer interface [polypeptide binding]; other site
546414009035	catalytic residue [active]
546414009036	nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790
546414009037	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
546414009038	dimer interface [polypeptide binding]; other site
546414009039	conserved gate region; other site
546414009040	putative PBP binding loops; other site
546414009041	ABC-ATPase subunit interface; other site
546414009042	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
546414009043	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
546414009044	dimer interface [polypeptide binding]; other site
546414009045	conserved gate region; other site
546414009046	putative PBP binding loops; other site
546414009047	ABC-ATPase subunit interface; other site
546414009048	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995
546414009049	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
546414009050	Transcriptional regulators [Transcription]; Region: FadR; COG2186
546414009051	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
546414009052	DNA-binding site [nucleotide binding]; DNA binding site
546414009053	FCD domain; Region: FCD; pfam07729
546414009054	N-acetylneuraminic acid mutarotase; Provisional; Region: PRK14131
546414009055	Galactose oxidase, central domain; Region: Kelch_3; cl02701
546414009056	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
546414009057	active site
546414009058	Int/Topo IB signature motif; other site
546414009059	catalytic residues [active]
546414009060	DNA binding site [nucleotide binding]
546414009061	Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148
546414009062	putative homotetramer interface [polypeptide binding]; other site
546414009063	putative homodimer interface [polypeptide binding]; other site
546414009064	putative allosteric switch controlling residues; other site
546414009065	putative metal binding site [ion binding]; other site
546414009066	putative homodimer-homodimer interface [polypeptide binding]; other site
546414009067	putative luciferase-like monooxygenase, FMN-dependent, CE1758 family; Region: LLM_CE1758_fam; TIGR04036
546414009068	probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858
546414009069	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
546414009070	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
546414009071	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
546414009072	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
546414009073	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
546414009074	MarR family; Region: MarR_2; pfam12802
546414009075	Predicted transcriptional regulator [Transcription]; Region: COG1959
546414009076	Transcriptional regulator; Region: Rrf2; pfam02082
546414009077	biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244
546414009078	NADH(P)-binding; Region: NAD_binding_10; pfam13460
546414009079	NAD binding site [chemical binding]; other site
546414009080	substrate binding site [chemical binding]; other site
546414009081	putative active site [active]
546414009082	Predicted protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: COG3531
546414009083	DsbA family, FrnE-like subfamily; composed of uncharacterized proteins containing a CXXC motif with similarity to DsbA and FrnE. FrnE is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the...; Region: DsbA_FrnE_like; cd03025
546414009084	catalytic residues [active]
546414009085	Transcriptional regulator [Transcription]; Region: LysR; COG0583
546414009086	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
546414009087	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
546414009088	dimerization interface [polypeptide binding]; other site
546414009089	Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897
546414009090	Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448
546414009091	active site residue [active]
546414009092	Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449
546414009093	active site residue [active]
546414009094	Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999
546414009095	SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968
546414009096	Cu(I) binding site [ion binding]; other site
546414009097	Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; cl09173
546414009098	Domain of unkown function (DUF1775); Region: DUF1775; pfam07987
546414009099	CopC domain; Region: CopC; cl01012
546414009100	Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897
546414009101	Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448
546414009102	active site residue [active]
546414009103	Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449
546414009104	active site residue [active]
546414009105	SnoaL-like domain; Region: SnoaL_2; pfam12680
546414009106	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
546414009107	Transcriptional regulator; Region: Rrf2; pfam02082
546414009108	Rrf2 family protein; Region: rrf2_super; TIGR00738
546414009109	Transcriptional regulator; Region: Rrf2; cl17282
546414009110	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
546414009111	Transcriptional regulator [Transcription]; Region: IclR; COG1414
546414009112	Bacterial transcriptional regulator; Region: IclR; pfam01614
546414009113	Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331
546414009114	Tripartite tricarboxylate transporter TctA family; Region: TctA; cl00772
546414009115	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181
546414009116	Putative D-3-Phosphoglycerate Dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_like_2; cd12172
546414009117	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
546414009118	putative ligand binding site [chemical binding]; other site
546414009119	putative NAD binding site [chemical binding]; other site
546414009120	catalytic site [active]
546414009121	hypothetical protein; Validated; Region: PRK06201
546414009122	Demethylmenaquinone methyltransferase [Coenzyme metabolism]; Region: MenG; COG0684
546414009123	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
546414009124	CoenzymeA binding site [chemical binding]; other site
546414009125	subunit interaction site [polypeptide binding]; other site
546414009126	PHB binding site; other site
546414009127	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
546414009128	CoenzymeA binding site [chemical binding]; other site
546414009129	subunit interaction site [polypeptide binding]; other site
546414009130	PHB binding site; other site
546414009131	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
546414009132	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
546414009133	LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cl04955
546414009134	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
546414009135	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
546414009136	Periplasmic binding domain of autoinducer-2 (AI-2) receptor LsrB from Salmonella typhimurium and its close homologs; Region: PBP1_LsrB_Quorum_Sensing; cd06302
546414009137	rhamnose ABC transporter, rhamnose-binding protein; Region: RhaS; TIGR02637
546414009138	ligand binding site [chemical binding]; other site
546414009139	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
546414009140	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
546414009141	TM-ABC transporter signature motif; other site
546414009142	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
546414009143	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
546414009144	TM-ABC transporter signature motif; other site
546414009145	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
546414009146	Walker B; other site
546414009147	D-loop; other site
546414009148	H-loop/switch region; other site
546414009149	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
546414009150	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
546414009151	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
546414009152	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
546414009153	Walker A/P-loop; other site
546414009154	ATP binding site [chemical binding]; other site
546414009155	Q-loop/lid; other site
546414009156	ABC transporter signature motif; other site
546414009157	Domain of unknown function (DUF718); Region: DUF718; pfam05336
546414009158	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
546414009159	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
546414009160	DNA-binding site [nucleotide binding]; DNA binding site
546414009161	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
546414009162	Predicted sugar isomerase [Cell envelope biogenesis, outer membrane]; Region: COG4952; cl17900
546414009163	short chain dehydrogenase; Validated; Region: PRK08324
546414009164	Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; smart01007
546414009165	rhamnulose-1-phosphate aldolase/alcohol dehydrogenase, classical (c) SDRs; Region: R1PA_ADH_SDR_c; cd08943
546414009166	putative NAD(P) binding site [chemical binding]; other site
546414009167	active site
546414009168	L-rhamnulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_RhuK; cd07771
546414009169	N- and C-terminal domain interface [polypeptide binding]; other site
546414009170	rhamnulokinase; Region: rhamnulo_kin; TIGR02627
546414009171	active site
546414009172	putative catalytic site [active]
546414009173	metal binding site [ion binding]; metal-binding site
546414009174	ATP binding site [chemical binding]; other site
546414009175	carbohydrate binding site [chemical binding]; other site
546414009176	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
546414009177	Cysteine-rich domain; Region: CCG; pfam02754
546414009178	Cysteine-rich domain; Region: CCG; pfam02754
546414009179	Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139
546414009180	Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589
546414009181	Domain of unknown function (DUF3390); Region: DUF3390; pfam11870
546414009182	Uncharacterized conserved protein [Function unknown]; Region: COG1556
546414009183	Cation transport protein; Region: TrkH; cl17365
546414009184	Prokaryotic protein of unknown function (DUF849); Region: DUF849; cl15827
546414009185	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
546414009186	Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102
546414009187	active site
546414009188	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
546414009189	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
546414009190	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
546414009191	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
546414009192	dimer interface [polypeptide binding]; other site
546414009193	conserved gate region; other site
546414009194	putative PBP binding loops; other site
546414009195	ABC-ATPase subunit interface; other site
546414009196	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
546414009197	dimer interface [polypeptide binding]; other site
546414009198	conserved gate region; other site
546414009199	putative PBP binding loops; other site
546414009200	ABC-ATPase subunit interface; other site
546414009201	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
546414009202	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
546414009203	active site
546414009204	motif I; other site
546414009205	motif II; other site
546414009206	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
546414009207	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
546414009208	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
546414009209	transaldolase-like protein; Provisional; Region: PTZ00411
546414009210	Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957
546414009211	active site
546414009212	dimer interface [polypeptide binding]; other site
546414009213	catalytic residue [active]
546414009214	glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100
546414009215	N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856
546414009216	Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326
546414009217	active site
546414009218	catalytic site [active]
546414009219	phosphodiesterase YaeI; Provisional; Region: PRK11340
546414009220	Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385
546414009221	putative active site [active]
546414009222	putative metal binding site [ion binding]; other site
546414009223	Cupin domain; Region: Cupin_2; cl17218
546414009224	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
546414009225	homotrimer interaction site [polypeptide binding]; other site
546414009226	putative active site [active]
546414009227	proline-specific peptidase, Bacillus coagulans-type subfamily; Region: pro_imino_pep_2; TIGR01250
546414009228	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
546414009229	GAF domain; Region: GAF; pfam01590
546414009230	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
546414009231	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
546414009232	active site
546414009233	phosphorylation site [posttranslational modification]
546414009234	intermolecular recognition site; other site
546414009235	dimerization interface [polypeptide binding]; other site
546414009236	Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412
546414009237	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
546414009238	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
546414009239	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
546414009240	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
546414009241	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
546414009242	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
546414009243	dimer interface [polypeptide binding]; other site
546414009244	conserved gate region; other site
546414009245	putative PBP binding loops; other site
546414009246	ABC-ATPase subunit interface; other site
546414009247	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
546414009248	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
546414009249	dimer interface [polypeptide binding]; other site
546414009250	conserved gate region; other site
546414009251	putative PBP binding loops; other site
546414009252	ABC-ATPase subunit interface; other site
546414009253	Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222
546414009254	SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389
546414009255	SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389
546414009256	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
546414009257	ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192
546414009258	substrate binding site [chemical binding]; other site
546414009259	ATP binding site [chemical binding]; other site
546414009260	Domain of unknown function (DUF4394); Region: DUF4394; pfam14339
546414009261	putative anti-sigmaE protein; Provisional; Region: PRK13920
546414009262	RNA polymerase sigma factor; Provisional; Region: PRK12514
546414009263	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
546414009264	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257
546414009265	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
546414009266	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_4; cd08500
546414009267	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
546414009268	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
546414009269	active site
546414009270	phosphorylation site [posttranslational modification]
546414009271	intermolecular recognition site; other site
546414009272	dimerization interface [polypeptide binding]; other site
546414009273	Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139
546414009274	hypothetical protein; Reviewed; Region: PRK09588
546414009275	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
546414009276	Domain of unknown function DUF21; Region: DUF21; pfam01595
546414009277	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
546414009278	Transporter associated domain; Region: CorC_HlyC; smart01091
546414009279	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
546414009280	Domain of unknown function DUF21; Region: DUF21; pfam01595
546414009281	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
546414009282	Transporter associated domain; Region: CorC_HlyC; smart01091
546414009283	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
546414009284	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
546414009285	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
546414009286	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
546414009287	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
546414009288	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
546414009289	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
546414009290	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
546414009291	dimer interface [polypeptide binding]; other site
546414009292	conserved gate region; other site
546414009293	putative PBP binding loops; other site
546414009294	ABC-ATPase subunit interface; other site
546414009295	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
546414009296	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
546414009297	ABC-ATPase subunit interface; other site
546414009298	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
546414009299	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
546414009300	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
546414009301	Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612
546414009302	Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744
546414009303	Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354
546414009304	ligand binding site [chemical binding]; other site
546414009305	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5339
546414009306	Bacterial protein of unknown function (DUF945); Region: DUF945; pfam06097
546414009307	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
546414009308	PAS domain; Region: PAS_9; pfam13426
546414009309	putative active site [active]
546414009310	heme pocket [chemical binding]; other site
546414009311	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
546414009312	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
546414009313	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
546414009314	CheB methylesterase; Region: CheB_methylest; pfam01339
546414009315	Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325
546414009316	Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529
546414009317	Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742
546414009318	This entry represents the core domain of the ferrous iron (Fe2+) transport protein FeoA found in bacteria; Region: FeoA; smart00899
546414009319	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
546414009320	Response regulator receiver domain; Region: Response_reg; pfam00072
546414009321	active site
546414009322	phosphorylation site [posttranslational modification]
546414009323	intermolecular recognition site; other site
546414009324	dimerization interface [polypeptide binding]; other site
546414009325	Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196
546414009326	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
546414009327	glycosyl hydrolase family 16; Region: Glyco_hydrolase_16; cd00413
546414009328	active site
546414009329	catalytic residues [active]
546414009330	Transcriptional regulators [Transcription]; Region: PurR; COG1609
546414009331	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
546414009332	DNA binding site [nucleotide binding]
546414009333	domain linker motif; other site
546414009334	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
546414009335	dimerization interface [polypeptide binding]; other site
546414009336	ligand binding site [chemical binding]; other site
546414009337	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
546414009338	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
546414009339	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
546414009340	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
546414009341	dimer interface [polypeptide binding]; other site
546414009342	conserved gate region; other site
546414009343	putative PBP binding loops; other site
546414009344	ABC-ATPase subunit interface; other site
546414009345	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
546414009346	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
546414009347	dimer interface [polypeptide binding]; other site
546414009348	conserved gate region; other site
546414009349	putative PBP binding loops; other site
546414009350	ABC-ATPase subunit interface; other site
546414009351	Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246
546414009352	Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232
546414009353	Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125
546414009354	Sorbitol dehydrogenase; Region: sorbitol_DH; cd05285
546414009355	inhibitor binding site; inhibition site
546414009356	catalytic Zn binding site [ion binding]; other site
546414009357	structural Zn binding site [ion binding]; other site
546414009358	NADP binding site [chemical binding]; other site
546414009359	tetramer interface [polypeptide binding]; other site
546414009360	cyanophycin synthetase; Region: cya_phycin_syn; TIGR02068
546414009361	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
546414009362	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
546414009363	spore photoproduct lyase family protein; Region: lyase_spl_fam; TIGR03886
546414009364	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
546414009365	sequence-specific DNA binding site [nucleotide binding]; other site
546414009366	salt bridge; other site
546414009367	ornithine cyclodeaminase; Validated; Region: PRK07340
546414009368	ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400
546414009369	PAS domain; Region: PAS; smart00091
546414009370	putative active site [active]
546414009371	heme pocket [chemical binding]; other site
546414009372	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
546414009373	GAF domain; Region: GAF; pfam01590
546414009374	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
546414009375	PAS fold; Region: PAS_3; pfam08447
546414009376	putative active site [active]
546414009377	heme pocket [chemical binding]; other site
546414009378	PAS domain S-box; Region: sensory_box; TIGR00229
546414009379	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
546414009380	putative active site [active]
546414009381	heme pocket [chemical binding]; other site
546414009382	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
546414009383	PAS domain; Region: PAS; smart00091
546414009384	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
546414009385	dimer interface [polypeptide binding]; other site
546414009386	phosphorylation site [posttranslational modification]
546414009387	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
546414009388	ATP binding site [chemical binding]; other site
546414009389	Mg2+ binding site [ion binding]; other site
546414009390	G-X-G motif; other site
546414009391	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
546414009392	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
546414009393	putative active site [active]
546414009394	Uncharacterized conserved protein [Function unknown]; Region: COG3342
546414009395	Family of unknown function (DUF1028); Region: DUF1028; pfam06267
546414009396	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
546414009397	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_11; cd08516
546414009398	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
546414009399	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
546414009400	dimer interface [polypeptide binding]; other site
546414009401	conserved gate region; other site
546414009402	putative PBP binding loops; other site
546414009403	ABC-ATPase subunit interface; other site
546414009404	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
546414009405	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
546414009406	dimer interface [polypeptide binding]; other site
546414009407	conserved gate region; other site
546414009408	putative PBP binding loops; other site
546414009409	ABC-ATPase subunit interface; other site
546414009410	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
546414009411	M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886
546414009412	metal binding site [ion binding]; metal-binding site
546414009413	dimer interface [polypeptide binding]; other site
546414009414	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
546414009415	The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493
546414009416	peptide binding site [polypeptide binding]; other site
546414009417	Anabaena sensory rhodopsin transducer; Region: ASRT; pfam07100
546414009418	FAD-linked oxidoreductase; Region: bact_FAD_ox; TIGR01679
546414009419	FAD binding domain; Region: FAD_binding_4; pfam01565
546414009420	D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030
546414009421	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
546414009422	probable non-F420 flavinoid oxidoreductase; Region: flavin_revert; TIGR03885
546414009423	N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097
546414009424	Predicted ATPase [General function prediction only]; Region: COG3903
546414009425	Tetratricopeptide repeat; Region: TPR_12; pfam13424
546414009426	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
546414009427	DNA binding residues [nucleotide binding]
546414009428	dimerization interface [polypeptide binding]; other site
546414009429	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
546414009430	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
546414009431	active site
546414009432	phosphorylation site [posttranslational modification]
546414009433	intermolecular recognition site; other site
546414009434	dimerization interface [polypeptide binding]; other site
546414009435	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
546414009436	DNA binding site [nucleotide binding]
546414009437	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
546414009438	putative active site [active]
546414009439	PAS fold; Region: PAS_3; pfam08447
546414009440	heme pocket [chemical binding]; other site
546414009441	PAS fold; Region: PAS_4; pfam08448
546414009442	GAF domain; Region: GAF_3; pfam13492
546414009443	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
546414009444	GAF domain; Region: GAF; pfam01590
546414009445	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
546414009446	dimer interface [polypeptide binding]; other site
546414009447	phosphorylation site [posttranslational modification]
546414009448	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
546414009449	ATP binding site [chemical binding]; other site
546414009450	Mg2+ binding site [ion binding]; other site
546414009451	G-X-G motif; other site
546414009452	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
546414009453	GAF domain; Region: GAF; pfam01590
546414009454	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
546414009455	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
546414009456	DNA binding site [nucleotide binding]
546414009457	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
546414009458	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
546414009459	Domain of unknown function (DUF4386); Region: DUF4386; pfam14329
546414009460	Response regulator receiver domain; Region: Response_reg; pfam00072
546414009461	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
546414009462	active site
546414009463	phosphorylation site [posttranslational modification]
546414009464	intermolecular recognition site; other site
546414009465	dimerization interface [polypeptide binding]; other site
546414009466	Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms]; Region: COG4251
546414009467	GAF domain; Region: GAF; pfam01590
546414009468	Phytochrome region; Region: PHY; pfam00360
546414009469	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
546414009470	dimer interface [polypeptide binding]; other site
546414009471	phosphorylation site [posttranslational modification]
546414009472	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
546414009473	ATP binding site [chemical binding]; other site
546414009474	Mg2+ binding site [ion binding]; other site
546414009475	G-X-G motif; other site
546414009476	putative cation:proton antiport protein; Provisional; Region: PRK10669
546414009477	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
546414009478	TrkA-N domain; Region: TrkA_N; pfam02254
546414009479	Predicted ornithine cyclodeaminase, mu-crystallin homolog [Amino acid transport and metabolism]; Region: COG2423
546414009480	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
546414009481	NAD(P) binding site [chemical binding]; other site
546414009482	Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171
546414009483	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
546414009484	tetramer interface [polypeptide binding]; other site
546414009485	pyridoxal 5'-phosphate binding site [chemical binding]; other site
546414009486	catalytic residue [active]
546414009487	YheO-like PAS domain; Region: PAS_6; pfam08348
546414009488	HTH domain; Region: HTH_22; pfam13309
546414009489	Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612
546414009490	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
546414009491	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
546414009492	putative DNA binding site [nucleotide binding]; other site
546414009493	dimerization interface [polypeptide binding]; other site
546414009494	putative Zn2+ binding site [ion binding]; other site
546414009495	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
546414009496	Low molecular weight phosphatase family; Region: LMWPc; cd00115
546414009497	active site
546414009498	Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cl00200
546414009499	amphipathic channel; other site
546414009500	Asn-Pro-Ala signature motifs; other site
546414009501	amphipathic channel; other site
546414009502	Asn-Pro-Ala signature motifs; other site
546414009503	Calcineurin-like phosphoesterase superfamily domain; Region: Metallophos_2; pfam12850
546414009504	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
546414009505	active site
546414009506	metal binding site [ion binding]; metal-binding site
546414009507	PAS fold; Region: PAS_4; pfam08448
546414009508	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
546414009509	GAF domain; Region: GAF_3; pfam13492
546414009510	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
546414009511	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
546414009512	dimer interface [polypeptide binding]; other site
546414009513	phosphorylation site [posttranslational modification]
546414009514	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
546414009515	ATP binding site [chemical binding]; other site
546414009516	Mg2+ binding site [ion binding]; other site
546414009517	G-X-G motif; other site
546414009518	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
546414009519	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
546414009520	active site
546414009521	phosphorylation site [posttranslational modification]
546414009522	intermolecular recognition site; other site
546414009523	dimerization interface [polypeptide binding]; other site
546414009524	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
546414009525	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
546414009526	WHG domain; Region: WHG; pfam13305
546414009527	Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249
546414009528	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
546414009529	Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; pfam09678
546414009530	Predicted membrane protein (DUF2243); Region: DUF2243; cl01783
546414009531	WGR domain of molybdate metabolism regulator and related proteins; Region: WGR_MMR_like; cd07996
546414009532	FOG: WD40-like repeat [Function unknown]; Region: COG1520
546414009533	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
546414009534	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
546414009535	DNA binding residues [nucleotide binding]
546414009536	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
546414009537	Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706
546414009538	Dienelactone hydrolase family; Region: DLH; pfam01738
546414009539	tRNA-binding-domain-containing CsaA-like proteins. CsaA is a molecular chaperone with export related activities. CsaA has a putative tRNA binding activity. The functional unit of CsaA is a homodimer and this domain acts as a dimerization domain; Region: tRNA_bind_CsaA; cd02798
546414009540	dimer interface [polypeptide binding]; other site
546414009541	putative tRNA-binding site [nucleotide binding]; other site
546414009542	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879
546414009543	Periplasmic binding domain of ABC-type YtfQ-like transport systems; Region: PBP1_YtfQ_like; cd06309
546414009544	putative ligand binding site [chemical binding]; other site
546414009545	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
546414009546	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
546414009547	Walker A/P-loop; other site
546414009548	ATP binding site [chemical binding]; other site
546414009549	Q-loop/lid; other site
546414009550	ABC transporter signature motif; other site
546414009551	Walker B; other site
546414009552	D-loop; other site
546414009553	H-loop/switch region; other site
546414009554	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
546414009555	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
546414009556	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
546414009557	TM-ABC transporter signature motif; other site
546414009558	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
546414009559	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
546414009560	TM-ABC transporter signature motif; other site
546414009561	Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312
546414009562	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
546414009563	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
546414009564	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
546414009565	Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738
546414009566	GAF domain; Region: GAF; pfam01590
546414009567	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
546414009568	PAS domain S-box; Region: sensory_box; TIGR00229
546414009569	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
546414009570	putative active site [active]
546414009571	heme pocket [chemical binding]; other site
546414009572	PAS fold; Region: PAS_4; pfam08448
546414009573	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
546414009574	putative active site [active]
546414009575	heme pocket [chemical binding]; other site
546414009576	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
546414009577	Zn2+ binding site [ion binding]; other site
546414009578	Mg2+ binding site [ion binding]; other site
546414009579	benzoate transporter; Region: benE; TIGR00843
546414009580	Benzoate membrane transport protein; Region: BenE; pfam03594
546414009581	Replication initiator protein A; Region: RPA; cl17860
546414009582	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
546414009583	extended (e) SDRs; Region: SDR_e; cd08946
546414009584	NAD(P) binding site [chemical binding]; other site
546414009585	active site
546414009586	short chain dehydrogenase; Provisional; Region: PRK07454
546414009587	classical (c) SDRs; Region: SDR_c; cd05233
546414009588	NAD(P) binding site [chemical binding]; other site
546414009589	active site
546414009590	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
546414009591	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
546414009592	active site
546414009593	catalytic tetrad [active]
546414009594	ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803
546414009595	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
546414009596	intersubunit interface [polypeptide binding]; other site
546414009597	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
546414009598	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
546414009599	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
546414009600	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
546414009601	ABC-ATPase subunit  interface; other site
546414009602	dimer interface [polypeptide binding]; other site
546414009603	putative PBP binding regions; other site
546414009604	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
546414009605	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
546414009606	ABC-ATPase subunit  interface; other site
546414009607	dimer interface [polypeptide binding]; other site
546414009608	putative PBP binding regions; other site
546414009609	Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325
546414009610	Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529
546414009611	Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742
546414009612	Protein of unknown function, DUF417; Region: DUF417; cl01162
546414009613	Subgroup of sulfite oxidase (SO) family molybdopterin binding domains that contains conserved dimerization domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate...; Region: SO_family_Moco_dimer; cd02110
546414009614	Moco binding site; other site
546414009615	metal coordination site [ion binding]; other site
546414009616	dimerization interface [polypeptide binding]; other site
546414009617	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
546414009618	DNA binding residues [nucleotide binding]
546414009619	Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044
546414009620	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
546414009621	Domain of unknown function (DUF4396); Region: DUF4396; pfam14342
546414009622	Replication initiator protein A; Region: RPA; cl17860
546414009623	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
546414009624	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
546414009625	P-loop; other site
546414009626	Magnesium ion binding site [ion binding]; other site
546414009627	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
546414009628	Magnesium ion binding site [ion binding]; other site
546414009629	ParB-like nuclease domain; Region: ParB; smart00470
546414009630	Replication initiator protein A; Region: RPA; cl17860
546414009631	2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase [Carbohydrate transport and metabolism]; Region: HpcH; COG3836
546414009632	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421
546414009633	3,4-dihydroxyphenylacetate 2,3-dioxygenase; Region: HpaD; TIGR02295
546414009634	N-terminal domain of 3,4-dihydroxyphenylacetate 2,3-dioxygenase (HPCD); belongs to the type I class II family of extradiol dioxygenases; Region: HPCD_N_class_II; cd07266
546414009635	tetramer interface [polypeptide binding]; other site
546414009636	C-terminal domain of 3,4-dihydroxyphenylacetate 2,3-dioxygenase (HPCD), which catalyses the second step in the degradation of 4-hydroxyphenylacetate to succinate and pyruvate; belongs to the type I class II family of extradiol dioxygenases; Region: HPCD_C_class_II; cd07256
546414009637	tetramer interface [polypeptide binding]; other site
546414009638	active site
546414009639	metal binding site [ion binding]; metal-binding site
546414009640	4-hydroxyphenylacetate 3-monooxygenase, oxygenase component; Region: HpaB-1; TIGR02309
546414009641	4-hydroxyphenylacetate 3-hydroxylase C terminal; Region: HpaB; pfam03241
546414009642	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
546414009643	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
546414009644	NAD(P) binding site [chemical binding]; other site
546414009645	active site
546414009646	5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenase; Region: HpaE; TIGR02299
546414009647	Human aldehyde dehydrogenase family 8 member A1-like; Region: ALDH_F8_HMSADH; cd07093
546414009648	NAD binding site [chemical binding]; other site
546414009649	catalytic residues [active]
546414009650	4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase, C-terminal subunit; Region: HpaG-C-term; TIGR02303
546414009651	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
546414009652	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
546414009653	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
546414009654	dimerization interface [polypeptide binding]; other site
546414009655	putative DNA binding site [nucleotide binding]; other site
546414009656	putative Zn2+ binding site [ion binding]; other site
546414009657	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
546414009658	Major Facilitator Superfamily; Region: MFS_1; pfam07690
546414009659	putative substrate translocation pore; other site
546414009660	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
546414009661	Type I periplasmic binding component of ABC (ATPase Binding Cassette)-type transport systems that are predicted to be involved in uptake of amino acids; Region: PBP1_ABC-type_HAAT_like; cd06333
546414009662	putative ligand binding site [chemical binding]; other site
546414009663	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
546414009664	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
546414009665	Walker A/P-loop; other site
546414009666	ATP binding site [chemical binding]; other site
546414009667	Q-loop/lid; other site
546414009668	ABC transporter signature motif; other site
546414009669	Walker B; other site
546414009670	D-loop; other site
546414009671	H-loop/switch region; other site
546414009672	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
546414009673	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
546414009674	TM-ABC transporter signature motif; other site
546414009675	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
546414009676	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
546414009677	Walker A/P-loop; other site
546414009678	ATP binding site [chemical binding]; other site
546414009679	Q-loop/lid; other site
546414009680	ABC transporter signature motif; other site
546414009681	Walker B; other site
546414009682	D-loop; other site
546414009683	H-loop/switch region; other site
546414009684	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
546414009685	TM-ABC transporter signature motif; other site
546414009686	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
546414009687	phenylacetate-CoA ligase; Region: PA_CoA_ligase; TIGR02155
546414009688	acyl-activating enzyme (AAE) consensus motif; other site
546414009689	AMP binding site [chemical binding]; other site
546414009690	active site
546414009691	CoA binding site [chemical binding]; other site
546414009692	G1P_TT_long represents the long form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_long; cd04189
546414009693	glucose-1-phosphate thymidylylransferase, long form; Region: rmlA_long; TIGR01208
546414009694	substrate binding site; other site
546414009695	metal-binding site
546414009696	Oligomer interface; other site
546414009697	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
546414009698	Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578
546414009699	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
546414009700	glycerol kinase; Provisional; Region: glpK; PRK00047
546414009701	Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786
546414009702	N- and C-terminal domain interface [polypeptide binding]; other site
546414009703	active site
546414009704	MgATP binding site [chemical binding]; other site
546414009705	catalytic site [active]
546414009706	metal binding site [ion binding]; metal-binding site
546414009707	glycerol binding site [chemical binding]; other site
546414009708	homotetramer interface [polypeptide binding]; other site
546414009709	homodimer interface [polypeptide binding]; other site
546414009710	FBP binding site [chemical binding]; other site
546414009711	protein IIAGlc interface [polypeptide binding]; other site
546414009712	Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333
546414009713	amphipathic channel; other site
546414009714	Asn-Pro-Ala signature motifs; other site
546414009715	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200
546414009716	Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390
546414009717	Putative sugar-binding domain; Region: Sugar-bind; pfam04198
546414009718	BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271
546414009719	Uncharacterized BCR, COG1649; Region: DUF187; pfam02638
546414009720	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
546414009721	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
546414009722	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
546414009723	dimer interface [polypeptide binding]; other site
546414009724	conserved gate region; other site
546414009725	putative PBP binding loops; other site
546414009726	ABC-ATPase subunit interface; other site
546414009727	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
546414009728	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
546414009729	dimer interface [polypeptide binding]; other site
546414009730	conserved gate region; other site
546414009731	putative PBP binding loops; other site
546414009732	ABC-ATPase subunit interface; other site
546414009733	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_4; cd08500
546414009734	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
546414009735	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
546414009736	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
546414009737	DNA-binding site [nucleotide binding]; DNA binding site
546414009738	UTRA domain; Region: UTRA; pfam07702
546414009739	anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585
546414009740	N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441
546414009741	N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007
546414009742	putative active site [active]
546414009743	Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753
546414009744	Clade 1 of the heme-binding enzyme catalase; Region: catalase_clade_1; cd08154
546414009745	tetramer interface [polypeptide binding]; other site
546414009746	heme binding pocket [chemical binding]; other site
546414009747	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
546414009748	metal binding site 2 [ion binding]; metal-binding site
546414009749	putative DNA binding helix; other site
546414009750	metal binding site 1 [ion binding]; metal-binding site
546414009751	dimer interface [polypeptide binding]; other site
546414009752	structural Zn2+ binding site [ion binding]; other site
546414009753	GAF domain; Region: GAF_3; pfam13492
546414009754	GAF domain; Region: GAF_2; pfam13185
546414009755	PAS domain S-box; Region: sensory_box; TIGR00229
546414009756	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
546414009757	putative active site [active]
546414009758	heme pocket [chemical binding]; other site
546414009759	PAS domain S-box; Region: sensory_box; TIGR00229
546414009760	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
546414009761	putative active site [active]
546414009762	heme pocket [chemical binding]; other site
546414009763	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
546414009764	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
546414009765	Zn2+ binding site [ion binding]; other site
546414009766	Mg2+ binding site [ion binding]; other site
546414009767	Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046
546414009768	dTDP-4-dehydrorhamnose reductase [Cell envelope biogenesis, outer membrane]; Region: RfbD; COG1091
546414009769	dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254
546414009770	NADP binding site [chemical binding]; other site
546414009771	active site
546414009772	putative substrate binding site [chemical binding]; other site
546414009773	TRX-like [2Fe-2S] Ferredoxin (Fd) family, Sucrase subfamily; composed of proteins with similarity to a novel plant enzyme, isolated from potato, which contains a Fd-like domain and exhibits sucrolytic activity. The putative active site of the Fd-like...; Region: TRX_Fd_Sucrase; cd03062
546414009774	putative dimer interface [polypeptide binding]; other site
546414009775	putative [2Fe-2S] cluster binding site [ion binding]; other site
546414009776	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
546414009777	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
546414009778	ABC-ATPase subunit  interface; other site
546414009779	dimer interface [polypeptide binding]; other site
546414009780	putative PBP binding regions; other site
546414009781	Fe3+-siderophore binding domain FhuD.  These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146
546414009782	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
546414009783	siderophore binding site; other site
546414009784	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462
546414009785	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
546414009786	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
546414009787	ABC-ATPase subunit  interface; other site
546414009788	dimer interface [polypeptide binding]; other site
546414009789	putative PBP binding regions; other site
546414009790	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
546414009791	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
546414009792	Walker A/P-loop; other site
546414009793	ATP binding site [chemical binding]; other site
546414009794	Q-loop/lid; other site
546414009795	ABC transporter signature motif; other site
546414009796	Walker B; other site
546414009797	D-loop; other site
546414009798	H-loop/switch region; other site
546414009799	Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485
546414009800	Zn binding site [ion binding]; other site
546414009801	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
546414009802	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
546414009803	catalytic residues [active]
546414009804	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; pfam02683
546414009805	Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785
546414009806	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
546414009807	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
546414009808	Transcriptional regulators [Transcription]; Region: PurR; COG1609
546414009809	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
546414009810	putative active site [active]
546414009811	heme pocket [chemical binding]; other site
546414009812	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
546414009813	GAF domain; Region: GAF; pfam01590
546414009814	PAS domain S-box; Region: sensory_box; TIGR00229
546414009815	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
546414009816	putative active site [active]
546414009817	heme pocket [chemical binding]; other site
546414009818	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
546414009819	dimer interface [polypeptide binding]; other site
546414009820	phosphorylation site [posttranslational modification]
546414009821	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
546414009822	ATP binding site [chemical binding]; other site
546414009823	Mg2+ binding site [ion binding]; other site
546414009824	G-X-G motif; other site
546414009825	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
546414009826	DNA binding site [nucleotide binding]
546414009827	active site
546414009828	Int/Topo IB signature motif; other site
546414009829	catalytic residues [active]
546414009830	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
546414009831	DNA binding site [nucleotide binding]
546414009832	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
546414009833	DNA-binding site [nucleotide binding]; DNA binding site
546414009834	RNA-binding motif; other site
546414009835	Rhodococcus ruber 6-oxolauric acid dehydrogenase-like; Region: ALDH_CddD_SSP0762; cd07138
546414009836	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
546414009837	NAD binding site [chemical binding]; other site
546414009838	catalytic residues [active]
546414009839	Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149
546414009840	substrate binding sites [chemical binding]; other site
546414009841	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
546414009842	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
546414009843	Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612
546414009844	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
546414009845	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
546414009846	active site
546414009847	phosphorylation site [posttranslational modification]
546414009848	intermolecular recognition site; other site
546414009849	dimerization interface [polypeptide binding]; other site
546414009850	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
546414009851	GAF domain; Region: GAF; pfam01590
546414009852	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
546414009853	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
546414009854	metal binding site [ion binding]; metal-binding site
546414009855	active site
546414009856	I-site; other site
546414009857	Bacterial protein of unknown function (DUF839); Region: DUF839; pfam05787
546414009858	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
546414009859	Beta-lactamase; Region: Beta-lactamase; pfam00144
546414009860	5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737
546414009861	CD73 ecto-5'-nucleotidase and related proteins, N-terminal metallophosphatase domain; Region: MPP_CD73_N; cd07409
546414009862	active site
546414009863	metal binding site [ion binding]; metal-binding site
546414009864	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
546414009865	heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386
546414009866	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
546414009867	dimerization interface [polypeptide binding]; other site
546414009868	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
546414009869	dimer interface [polypeptide binding]; other site
546414009870	phosphorylation site [posttranslational modification]
546414009871	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
546414009872	ATP binding site [chemical binding]; other site
546414009873	Mg2+ binding site [ion binding]; other site
546414009874	G-X-G motif; other site
546414009875	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
546414009876	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
546414009877	active site
546414009878	phosphorylation site [posttranslational modification]
546414009879	intermolecular recognition site; other site
546414009880	dimerization interface [polypeptide binding]; other site
546414009881	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
546414009882	DNA binding site [nucleotide binding]
546414009883	PAS domain S-box; Region: sensory_box; TIGR00229
546414009884	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
546414009885	putative active site [active]
546414009886	heme pocket [chemical binding]; other site
546414009887	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
546414009888	GAF domain; Region: GAF_3; pfam13492
546414009889	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
546414009890	dimer interface [polypeptide binding]; other site
546414009891	phosphorylation site [posttranslational modification]
546414009892	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
546414009893	ATP binding site [chemical binding]; other site
546414009894	Mg2+ binding site [ion binding]; other site
546414009895	G-X-G motif; other site
546414009896	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
546414009897	sugar efflux transporter; Region: 2A0120; TIGR00899
546414009898	Predicted acetamidase/formamidase [Energy production and conversion]; Region: COG2421
546414009899	YciF bacterial stress response protein, ferritin-like iron-binding domain; Region: YciF; cd07909
546414009900	dimerization interface [polypeptide binding]; other site
546414009901	metal binding site [ion binding]; metal-binding site
546414009902	Fimbrillin-A associated anchor proteins Mfa1 and Mfa2; Region: Mfa2; pfam08842
546414009903	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
546414009904	Colicin V production protein; Region: Colicin_V; pfam02674
546414009905	Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340
546414009906	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
546414009907	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
546414009908	Prokaryotic Ubiquitin; Region: Prok_Ub; cl14020
546414009909	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836
546414009910	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
546414009911	Major Facilitator Superfamily; Region: MFS_1; pfam07690
546414009912	putative substrate translocation pore; other site
546414009913	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
546414009914	Transposase; Region: HTH_Tnp_1; pfam01527
546414009915	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
546414009916	putative transposase OrfB; Reviewed; Region: PHA02517
546414009917	HTH-like domain; Region: HTH_21; pfam13276
546414009918	Integrase core domain; Region: rve; pfam00665
546414009919	Integrase core domain; Region: rve_3; pfam13683
546414009920	ribonuclease Z; Provisional; Region: PRK02126
546414009921	Tetratricopeptide repeat; Region: TPR_12; pfam13424
546414009922	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
546414009923	binding surface
546414009924	TPR motif; other site
546414009925	Tetratricopeptide repeat; Region: TPR_12; pfam13424
546414009926	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
546414009927	binding surface
546414009928	TPR motif; other site
546414009929	Tetratricopeptide repeat; Region: TPR_12; pfam13424
546414009930	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
546414009931	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
546414009932	Zn2+ binding site [ion binding]; other site
546414009933	Mg2+ binding site [ion binding]; other site
546414009934	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
546414009935	binding surface
546414009936	TPR motif; other site
546414009937	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
546414009938	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
546414009939	metal binding site [ion binding]; metal-binding site
546414009940	active site
546414009941	I-site; other site
546414009942	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
546414009943	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
546414009944	Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612
546414009945	Tubulin like; Region: Tubulin_2; pfam13809
546414009946	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
546414009947	ligand binding site [chemical binding]; other site
546414009948	putative oxidoreductase/HEAT repeat-containing protein; Provisional; Region: PRK13800
546414009949	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
546414009950	active site
546414009951	ATP binding site [chemical binding]; other site
546414009952	substrate binding site [chemical binding]; other site
546414009953	activation loop (A-loop); other site
546414009954	Bacterial SH3 domain homologues; Region: SH3b; smart00287
546414009955	Right handed beta helix region; Region: Beta_helix; pfam13229
546414009956	parallel beta-helix repeat (two copies); Region: para_beta_helix; TIGR03804
546414009957	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
546414009958	helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785
546414009959	ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains) [DNA replication, recombination, and repair]; Region: RecB; COG1074
546414009960	Family description; Region: UvrD_C_2; pfam13538
546414009961	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
546414009962	putative transposase OrfB; Reviewed; Region: PHA02517
546414009963	HTH-like domain; Region: HTH_21; pfam13276
546414009964	Integrase core domain; Region: rve; pfam00665
546414009965	Integrase core domain; Region: rve_3; pfam13683
546414009966	Transposase; Region: HTH_Tnp_1; pfam01527
546414009967	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
546414009968	Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053
546414009969	active site
546414009970	Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304
546414009971	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
546414009972	metal ion-dependent adhesion site (MIDAS); other site
546414009973	alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561
546414009974	Transcriptional regulators [Transcription]; Region: PurR; COG1609
546414009975	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
546414009976	DNA binding site [nucleotide binding]
546414009977	domain linker motif; other site
546414009978	Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_9; cd06290
546414009979	putative dimerization interface [polypeptide binding]; other site
546414009980	putative ligand binding site [chemical binding]; other site
546414009981	Glycosyl hydrolase family 81; Region: Glyco_hydro_81; cl02310
546414009982	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
546414009983	Interdomain contacts; other site
546414009984	Cytokine receptor motif; other site
546414009985	integron integrase; Region: integrase_gron; TIGR02249
546414009986	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
546414009987	active site
546414009988	DNA binding site [nucleotide binding]
546414009989	Int/Topo IB signature motif; other site
546414009990	Erythromycin esterase; Region: Erythro_esteras; pfam05139
546414009991	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
546414009992	active site
546414009993	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
546414009994	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
546414009995	dimerization interface [polypeptide binding]; other site
546414009996	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
546414009997	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
546414009998	dimerization interface [polypeptide binding]; other site
546414009999	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
546414010000	dimerization interface [polypeptide binding]; other site
546414010001	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
546414010002	dimerization interface [polypeptide binding]; other site
546414010003	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
546414010004	dimerization interface [polypeptide binding]; other site
546414010005	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
546414010006	dimerization interface [polypeptide binding]; other site
546414010007	GAF domain; Region: GAF_2; pfam13185
546414010008	GAF domain; Region: GAF; pfam01590
546414010009	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
546414010010	dimer interface [polypeptide binding]; other site
546414010011	phosphorylation site [posttranslational modification]
546414010012	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
546414010013	ATP binding site [chemical binding]; other site
546414010014	Mg2+ binding site [ion binding]; other site
546414010015	G-X-G motif; other site
546414010016	Response regulator receiver domain; Region: Response_reg; pfam00072
546414010017	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
546414010018	active site
546414010019	phosphorylation site [posttranslational modification]
546414010020	intermolecular recognition site; other site
546414010021	dimerization interface [polypeptide binding]; other site
546414010022	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
546414010023	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
546414010024	active site
546414010025	phosphorylation site [posttranslational modification]
546414010026	intermolecular recognition site; other site
546414010027	dimerization interface [polypeptide binding]; other site
546414010028	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
546414010029	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
546414010030	active site
546414010031	phosphorylation site [posttranslational modification]
546414010032	intermolecular recognition site; other site
546414010033	dimerization interface [polypeptide binding]; other site
546414010034	CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705
546414010035	Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352
546414010036	CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739
546414010037	Response regulator receiver domain; Region: Response_reg; pfam00072
546414010038	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
546414010039	active site
546414010040	phosphorylation site [posttranslational modification]
546414010041	intermolecular recognition site; other site
546414010042	dimerization interface [polypeptide binding]; other site
546414010043	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
546414010044	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
546414010045	putative active site [active]
546414010046	heme pocket [chemical binding]; other site
546414010047	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
546414010048	dimer interface [polypeptide binding]; other site
546414010049	phosphorylation site [posttranslational modification]
546414010050	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
546414010051	ATP binding site [chemical binding]; other site
546414010052	Mg2+ binding site [ion binding]; other site
546414010053	G-X-G motif; other site
546414010054	GAF domain; Region: GAF; pfam01590
546414010055	GAF domain; Region: GAF_2; pfam13185
546414010056	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
546414010057	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
546414010058	metal binding site [ion binding]; metal-binding site
546414010059	active site
546414010060	I-site; other site
546414010061	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
546414010062	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
546414010063	substrate binding pocket [chemical binding]; other site
546414010064	membrane-bound complex binding site; other site
546414010065	hinge residues; other site
546414010066	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
546414010067	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
546414010068	dimerization interface [polypeptide binding]; other site
546414010069	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
546414010070	dimer interface [polypeptide binding]; other site
546414010071	phosphorylation site [posttranslational modification]
546414010072	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
546414010073	ATP binding site [chemical binding]; other site
546414010074	Mg2+ binding site [ion binding]; other site
546414010075	G-X-G motif; other site
546414010076	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
546414010077	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
546414010078	active site
546414010079	phosphorylation site [posttranslational modification]
546414010080	intermolecular recognition site; other site
546414010081	dimerization interface [polypeptide binding]; other site
546414010082	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
546414010083	DNA binding site [nucleotide binding]
546414010084	Domain of unknown function (DUF305); Region: DUF305; pfam03713
546414010085	GAF domain; Region: GAF_3; pfam13492
546414010086	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
546414010087	dimer interface [polypeptide binding]; other site
546414010088	phosphorylation site [posttranslational modification]
546414010089	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
546414010090	ATP binding site [chemical binding]; other site
546414010091	Mg2+ binding site [ion binding]; other site
546414010092	G-X-G motif; other site
546414010093	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
546414010094	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
546414010095	active site
546414010096	phosphorylation site [posttranslational modification]
546414010097	intermolecular recognition site; other site
546414010098	dimerization interface [polypeptide binding]; other site
546414010099	Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms]; Region: COG4251
546414010100	GAF domain; Region: GAF; pfam01590
546414010101	Phytochrome region; Region: PHY; pfam00360
546414010102	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
546414010103	ATP binding site [chemical binding]; other site
546414010104	Mg2+ binding site [ion binding]; other site
546414010105	G-X-G motif; other site
546414010106	Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cd00232
546414010107	heme binding pocket [chemical binding]; other site
546414010108	heme ligand [chemical binding]; other site
546414010109	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
546414010110	S-adenosylmethionine binding site [chemical binding]; other site
546414010111	Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683
546414010112	active site lid residues [active]
546414010113	substrate binding pocket [chemical binding]; other site
546414010114	catalytic residues [active]
546414010115	substrate-Mg2+ binding site; other site
546414010116	aspartate-rich region 1; other site
546414010117	aspartate-rich region 2; other site
546414010118	phytoene desaturase; Region: crtI_fam; TIGR02734
546414010119	Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233
546414010120	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
546414010121	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
546414010122	active site
546414010123	Predicted membrane protein [Function unknown]; Region: COG4270
546414010124	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
546414010125	Phosphate acyltransferases; Region: PlsC; smart00563
546414010126	putative acyl-acceptor binding pocket; other site
546414010127	lycopene cyclase domain; Region: CarR_dom_SF; TIGR03462
546414010128	lycopene cyclase domain; Region: CarR_dom_SF; TIGR03462
546414010129	Protein of unknown function (DUF422); Region: DUF422; pfam04240
546414010130	Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233
546414010131	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
546414010132	RAB proteins geranylgeranyltransferase component A (RAB escort protein) [Posttranslational modification, protein turnover, chaperones]; Region: MRS6; cl17678
546414010133	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: GT1_like_1; cd04950
546414010134	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
546414010135	putative homodimer interface [polypeptide binding]; other site
546414010136	UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562
546414010137	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
546414010138	UDP-galactopyranose mutase; Region: GLF; pfam03275
546414010139	FRG domain; Region: FRG; pfam08867
546414010140	cyanophycin synthetase; Provisional; Region: PRK14016
546414010141	ATP-grasp domain; Region: ATP-grasp_4; pfam13535
546414010142	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
546414010143	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
546414010144	Ntn-hydrolase superfamily, L-Asparaginase type 2-like enzymes. This family includes Glycosylasparaginase, Taspase 1 and  L-Asparaginase type 2 enzymes. Glycosylasparaginase catalyzes the hydrolysis of the glycosylamide bond of asparagine-linked...; Region: Ntn_Asparaginase_2_like; cl00635
546414010145	active site
546414010146	dimer interface [polypeptide binding]; other site
546414010147	catalytic nucleophile [active]
546414010148	Type 1 glutamine amidotransferase (GATase1)-like domain found in cyanophycinase; Region: GAT1_cyanophycinase; cd03145
546414010149	proposed catalytic triad [active]
546414010150	active site nucleophile [active]
546414010151	N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853
546414010152	malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402
546414010153	Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325
546414010154	catalytic site [active]
546414010155	active site
546414010156	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
546414010157	Uncharacterized protein conserved in bacteria (DUF2171); Region: DUF2171; cl01558
546414010158	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
546414010159	Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297
546414010160	intersubunit interface [polypeptide binding]; other site
546414010161	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
546414010162	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
546414010163	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
546414010164	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
546414010165	ABC-ATPase subunit  interface; other site
546414010166	dimer interface [polypeptide binding]; other site
546414010167	putative PBP binding regions; other site
546414010168	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
546414010169	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
546414010170	ABC-ATPase subunit  interface; other site
546414010171	dimer interface [polypeptide binding]; other site
546414010172	putative PBP binding regions; other site
546414010173	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
546414010174	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
546414010175	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
546414010176	Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412
546414010177	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
546414010178	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
546414010179	Major Facilitator Superfamily; Region: MFS_1; pfam07690
546414010180	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
546414010181	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
546414010182	active site
546414010183	ornithine--oxo-acid transaminase; Provisional; Region: rocD; PRK04073
546414010184	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
546414010185	inhibitor-cofactor binding pocket; inhibition site
546414010186	pyridoxal 5'-phosphate binding site [chemical binding]; other site
546414010187	catalytic residue [active]
546414010188	Predicted amidohydrolase [General function prediction only]; Region: COG0388
546414010189	Nitrilases, cyanide hydratase (CH)s, and similar proteins (class 1 nitrilases); Region: nitrilases_CHs; cd07564
546414010190	putative active site [active]
546414010191	catalytic triad [active]
546414010192	putative dimer interface [polypeptide binding]; other site
546414010193	N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346
546414010194	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
546414010195	Zn binding site [ion binding]; other site
546414010196	C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347
546414010197	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
546414010198	Zn binding site [ion binding]; other site
546414010199	Predicted esterase [General function prediction only]; Region: COG0400
546414010200	putative hydrolase; Provisional; Region: PRK11460
546414010201	tryptophan 2,3-dioxygenase; Region: trp_2_3_diox; TIGR03036
546414010202	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
546414010203	kynureninase; Region: kynureninase; TIGR01814
546414010204	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
546414010205	catalytic residue [active]
546414010206	Cobalamin-5-phosphate synthase [Coenzyme metabolism]; Region: CobS; COG0368
546414010207	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
546414010208	catalytic core [active]
546414010209	Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086
546414010210	putative catalytic site [active]
546414010211	putative phosphate binding site [ion binding]; other site
546414010212	active site
546414010213	metal binding site A [ion binding]; metal-binding site
546414010214	DNA binding site [nucleotide binding]
546414010215	putative AP binding site [nucleotide binding]; other site
546414010216	putative metal binding site B [ion binding]; other site
546414010217	oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890
546414010218	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
546414010219	formate dehydrogenase accessory protein; Reviewed; Region: PRK00724
546414010220	Protein of unknown function (DUF1641); Region: DUF1641; cl01025
546414010221	Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383
546414010222	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510
546414010223	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; cl11210
546414010224	4Fe-4S binding domain; Region: Fer4; pfam00037
546414010225	4Fe-4S binding domain; Region: Fer4; pfam00037
546414010226	Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753
546414010227	[4Fe-4S] binding site [ion binding]; other site
546414010228	molybdopterin cofactor binding site; other site
546414010229	Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792
546414010230	molybdopterin cofactor binding site; other site
546414010231	Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482
546414010232	Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429
546414010233	Periplasmic binding protein YvrC.  These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria and archaea.  They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: YvrC; cd01143
546414010234	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
546414010235	putative binding site residues; other site
546414010236	ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109
546414010237	ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561
546414010238	homodimer interface [polypeptide binding]; other site
546414010239	Walker A motif; other site
546414010240	ATP binding site [chemical binding]; other site
546414010241	hydroxycobalamin binding site [chemical binding]; other site
546414010242	Walker B motif; other site
546414010243	Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644
546414010244	active site
546414010245	putative homodimer interface [polypeptide binding]; other site
546414010246	SAM binding site [chemical binding]; other site
546414010247	Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138
546414010248	Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416
546414010249	putative active site [active]
546414010250	Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414
546414010251	putative active site [active]
546414010252	Precorrin-8X methylmutase; Region: CbiC; pfam02570
546414010253	cobalt-precorrin-8X methylmutase; Validated; Region: cbiC; cl00913
546414010254	cobalt-precorrin-6A synthase; Reviewed; Region: cbiD; PRK00075
546414010255	Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645
546414010256	active site
546414010257	SAM binding site [chemical binding]; other site
546414010258	homodimer interface [polypeptide binding]; other site
546414010259	Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641
546414010260	active site
546414010261	SAM binding site [chemical binding]; other site
546414010262	homodimer interface [polypeptide binding]; other site
546414010263	Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760
546414010264	cobalamin biosynthesis protein CbiG; Provisional; Region: PRK07027
546414010265	Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646
546414010266	active site
546414010267	SAM binding site [chemical binding]; other site
546414010268	homodimer interface [polypeptide binding]; other site
546414010269	Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099
546414010270	Precorrin-6x reductase CbiJ/CobK; Region: CbiJ; pfam02571
546414010271	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
546414010272	CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492
546414010273	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683
546414010274	High-affinity nickel-transport protein; Region: NicO; cl00964
546414010275	Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer,  utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514
546414010276	FMN binding site [chemical binding]; other site
546414010277	dimer interface [polypeptide binding]; other site
546414010278	cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK05989
546414010279	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
546414010280	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
546414010281	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
546414010282	cobaltochelatase subunit; Region: Cob-chelat-sub; TIGR02442
546414010283	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078
546414010284	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
546414010285	metal ion-dependent adhesion site (MIDAS); other site
546414010286	cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077
546414010287	Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132
546414010288	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130
546414010289	catalytic triad [active]
546414010290	CobD/Cbib protein; Region: CobD_Cbib; pfam03186
546414010291	Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079
546414010292	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
546414010293	pyridoxal 5'-phosphate binding site [chemical binding]; other site
546414010294	homodimer interface [polypeptide binding]; other site
546414010295	catalytic residue [active]
546414010296	Transcriptional regulators [Transcription]; Region: PurR; COG1609
546414010297	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
546414010298	DNA binding site [nucleotide binding]
546414010299	domain linker motif; other site
546414010300	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
546414010301	dimerization interface [polypeptide binding]; other site
546414010302	ligand binding site [chemical binding]; other site
546414010303	alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403
546414010304	Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333
546414010305	Ca binding site [ion binding]; other site
546414010306	active site
546414010307	catalytic site [active]
546414010308	Domain of unknown function (DUF3459); Region: DUF3459; pfam11941
546414010309	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
546414010310	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
546414010311	Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296
546414010312	putative active site [active]
546414010313	TPR repeat; Region: TPR_11; pfam13414
546414010314	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
546414010315	TPR motif; other site
546414010316	binding surface
546414010317	M20 Peptidase Aminoacylase 1-like protein 2 aminobenzoyl-glutamate utilization protein B subfamily; Region: M20_Acy1L2_AbgB; cd05673
546414010318	amidohydrolase; Region: amidohydrolases; TIGR01891
546414010319	putative metal binding site [ion binding]; other site
546414010320	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
546414010321	Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107
546414010322	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
546414010323	DNA binding residues [nucleotide binding]
546414010324	drug binding residues [chemical binding]; other site
546414010325	dimer interface [polypeptide binding]; other site
546414010326	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
546414010327	cobyric acid synthase; Provisional; Region: PRK00784
546414010328	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
546414010329	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750
546414010330	catalytic triad [active]
546414010331	Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544
546414010332	homotrimer interface [polypeptide binding]; other site
546414010333	Walker A motif; other site
546414010334	GTP binding site [chemical binding]; other site
546414010335	Walker B motif; other site
546414010336	Phosphoribosyltransferase; Region: DBI_PRT; pfam02277
546414010337	Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439
546414010338	putative dimer interface [polypeptide binding]; other site
546414010339	active site pocket [active]
546414010340	putative cataytic base [active]
546414010341	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
546414010342	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
546414010343	amidase catalytic site [active]
546414010344	Zn binding residues [ion binding]; other site
546414010345	substrate binding site [chemical binding]; other site
546414010346	Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409
546414010347	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
546414010348	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
546414010349	Esterase PHB depolymerase; Region: Esterase_phd; pfam10503
546414010350	phosphate ABC transporter, phosphate-binding protein; Region: 3a0107s03; TIGR00975
546414010351	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573
546414010352	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
546414010353	dimer interface [polypeptide binding]; other site
546414010354	conserved gate region; other site
546414010355	putative PBP binding loops; other site
546414010356	ABC-ATPase subunit interface; other site
546414010357	phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974
546414010358	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
546414010359	dimer interface [polypeptide binding]; other site
546414010360	conserved gate region; other site
546414010361	putative PBP binding loops; other site
546414010362	ABC-ATPase subunit interface; other site
546414010363	phosphate ABC transporter ATP-binding protein; Provisional; Region: PRK14272
546414010364	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
546414010365	Walker A/P-loop; other site
546414010366	ATP binding site [chemical binding]; other site
546414010367	Q-loop/lid; other site
546414010368	ABC transporter signature motif; other site
546414010369	Walker B; other site
546414010370	D-loop; other site
546414010371	H-loop/switch region; other site
546414010372	Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071
546414010373	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745
546414010374	catalytic triad [active]
546414010375	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08314
546414010376	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
546414010377	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
546414010378	acyl-activating enzyme (AAE) consensus motif; other site
546414010379	AMP binding site [chemical binding]; other site
546414010380	active site
546414010381	CoA binding site [chemical binding]; other site
546414010382	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
546414010383	IHF - DNA interface [nucleotide binding]; other site
546414010384	IHF dimer interface [polypeptide binding]; other site
546414010385	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
546414010386	catalytic core [active]
546414010387	Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154
546414010388	Phosphotransferase enzyme family; Region: APH; pfam01636
546414010389	putative active site [active]
546414010390	putative substrate binding site [chemical binding]; other site
546414010391	ATP binding site [chemical binding]; other site
546414010392	hypothetical protein; Provisional; Region: PRK06194
546414010393	classical (c) SDRs; Region: SDR_c; cd05233
546414010394	NAD(P) binding site [chemical binding]; other site
546414010395	active site
546414010396	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
546414010397	classical (c) SDRs; Region: SDR_c; cd05233
546414010398	NAD(P) binding site [chemical binding]; other site
546414010399	active site
546414010400	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
546414010401	Acyl-CoA dehydrogenases similar to fadE2; Region: ACAD_FadE2; cd01155
546414010402	FAD binding site [chemical binding]; other site
546414010403	substrate binding site [chemical binding]; other site
546414010404	catalytic base [active]
546414010405	NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit.  Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450
546414010406	putative active site [active]
546414010407	putative catalytic site [active]
546414010408	gluconate 5-dehydrogenase; Provisional; Region: PRK08213
546414010409	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
546414010410	NAD(P) binding site [chemical binding]; other site
546414010411	active site
546414010412	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
546414010413	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
546414010414	active site
546414010415	phosphorylation site [posttranslational modification]
546414010416	intermolecular recognition site; other site
546414010417	dimerization interface [polypeptide binding]; other site
546414010418	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
546414010419	Glycerophosphodiester phosphodiesterase domain as found in prokaryota and eukaryota, and similar proteins; Region: GDPD; cd08556
546414010420	active site
546414010421	catalytic site [active]
546414010422	metal binding site [ion binding]; metal-binding site
546414010423	Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178
546414010424	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
546414010425	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
546414010426	ABC transporter signature motif; other site
546414010427	Walker B; other site
546414010428	D-loop; other site
546414010429	H-loop/switch region; other site
546414010430	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
546414010431	Walker A/P-loop; other site
546414010432	ATP binding site [chemical binding]; other site
546414010433	Q-loop/lid; other site
546414010434	ABC transporter signature motif; other site
546414010435	Walker B; other site
546414010436	D-loop; other site
546414010437	H-loop/switch region; other site
546414010438	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
546414010439	putative substrate translocation pore; other site
546414010440	Major Facilitator Superfamily; Region: MFS_1; pfam07690
546414010441	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
546414010442	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
546414010443	TAP-like protein; Region: Abhydrolase_4; pfam08386
546414010444	Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418
546414010445	acyl-CoA dehydrogenase; Provisional; Region: PTZ00456
546414010446	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
546414010447	active site
546414010448	Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806
546414010449	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
546414010450	Quinone oxidoreductase (QOR); Region: QOR1; cd08241
546414010451	NAD(P) binding site [chemical binding]; other site
546414010452	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
546414010453	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
546414010454	DNA binding residues [nucleotide binding]
546414010455	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
546414010456	dimer interface [polypeptide binding]; other site
546414010457	conserved gate region; other site
546414010458	putative PBP binding loops; other site
546414010459	ABC-ATPase subunit interface; other site
546414010460	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
546414010461	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
546414010462	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
546414010463	PAS domain; Region: PAS_9; pfam13426
546414010464	putative active site [active]
546414010465	heme pocket [chemical binding]; other site
546414010466	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
546414010467	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
546414010468	PAS domain S-box; Region: sensory_box; TIGR00229
546414010469	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
546414010470	heme pocket [chemical binding]; other site
546414010471	putative active site [active]
546414010472	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
546414010473	GAF domain; Region: GAF; pfam01590
546414010474	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
546414010475	dimer interface [polypeptide binding]; other site
546414010476	phosphorylation site [posttranslational modification]
546414010477	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
546414010478	ATP binding site [chemical binding]; other site
546414010479	Mg2+ binding site [ion binding]; other site
546414010480	G-X-G motif; other site
546414010481	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
546414010482	Coenzyme A binding pocket [chemical binding]; other site
546414010483	PAS domain S-box; Region: sensory_box; TIGR00229
546414010484	PAS fold; Region: PAS_4; pfam08448
546414010485	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
546414010486	PAS domain; Region: PAS_9; pfam13426
546414010487	putative active site [active]
546414010488	heme pocket [chemical binding]; other site
546414010489	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
546414010490	GAF domain; Region: GAF; pfam01590
546414010491	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
546414010492	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
546414010493	metal binding site [ion binding]; metal-binding site
546414010494	active site
546414010495	I-site; other site
546414010496	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
546414010497	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
546414010498	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736
546414010499	active site
546414010500	phosphorylation site [posttranslational modification]
546414010501	intermolecular recognition site; other site
546414010502	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
546414010503	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
546414010504	metal binding site [ion binding]; metal-binding site
546414010505	active site
546414010506	I-site; other site
546414010507	Protein of unknown function (DUF1648); Region: DUF1648; pfam07853
546414010508	DNA-binding transcriptional activator of the SARP family [Signal transduction mechanisms]; Region: DnrI; COG3629
546414010509	Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404
546414010510	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
546414010511	active site
546414010512	catalytic residues [active]
546414010513	Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151
546414010514	galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019
546414010515	active site
546414010516	catalytic residues [active]
546414010517	HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228
546414010518	Galactose-1-phosphate uridylyltransferase [Energy production and conversion]; Region: GalT; COG1085
546414010519	nucleotide binding site/active site [active]
546414010520	HIT family signature motif; other site
546414010521	catalytic residue [active]
546414010522	Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509
546414010523	galactokinase; Provisional; Region: PRK03817
546414010524	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
546414010525	Formylmethanofuran dehydrogenase subunit B [Energy production and conversion]; Region: FwdB; COG1029
546414010526	short chain dehydrogenase; Provisional; Region: PRK06701
546414010527	classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355
546414010528	NAD binding site [chemical binding]; other site
546414010529	metal binding site [ion binding]; metal-binding site
546414010530	active site
546414010531	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
546414010532	conserved cys residue [active]
546414010533	DinB family; Region: DinB; cl17821
546414010534	DinB superfamily; Region: DinB_2; pfam12867