-- dump date   	20140619_054338
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
755178000001	Protein of unknown function (DUF3386); Region: DUF3386; pfam11866
755178000002	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
755178000003	tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617
755178000004	active site
755178000005	NTP binding site [chemical binding]; other site
755178000006	metal binding triad [ion binding]; metal-binding site
755178000007	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
755178000008	tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735
755178000009	CHAT domain; Region: CHAT; cl17868
755178000010	Macro domain, a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases). Some macro domains recognize poly...; Region: Macro; cl00019
755178000011	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
755178000012	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
755178000013	atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242
755178000014	Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090
755178000015	putative NAD(P) binding site [chemical binding]; other site
755178000016	putative active site [active]
755178000017	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
755178000018	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
755178000019	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
755178000020	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
755178000021	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
755178000022	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
755178000023	Alpha-mannosidase [Carbohydrate transport and metabolism]; Region: AMS1; COG0383
755178000024	N-terminal catalytic domain of endoplasmic reticulum(ER)/cytosolic class II alpha-mannosidases; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_ER_cytosolic; cd10789
755178000025	active site
755178000026	catalytic site [active]
755178000027	Alpha mannosidase, middle domain; Region: Alpha-mann_mid; pfam09261
755178000028	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB-like; cd09875
755178000029	putative active site [active]
755178000030	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
755178000031	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
755178000032	active site
755178000033	catalytic tetrad [active]
755178000034	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
755178000035	Catalytic domain of Protein Kinases; Region: PKc; cd00180
755178000036	active site
755178000037	ATP binding site [chemical binding]; other site
755178000038	substrate binding site [chemical binding]; other site
755178000039	activation loop (A-loop); other site
755178000040	The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505
755178000041	Fatty acid desaturase; Region: FA_desaturase; pfam00487
755178000042	Di-iron ligands [ion binding]; other site
755178000043	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
755178000044	FAD binding domain; Region: FAD_binding_4; pfam01565
755178000045	Uncharacterized protein involved in cytokinesis, contains TGc (transglutaminase/protease-like) domain [Cell division and chromosome partitioning]; Region: CYK3; COG5279
755178000046	Transglutaminase/protease-like homologues; Region: TGc; smart00460
755178000047	AAA domain; Region: AAA_26; pfam13500
755178000048	dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090
755178000049	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK02812
755178000050	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
755178000051	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
755178000052	active site
755178000053	aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874
755178000054	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
755178000055	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
755178000056	dihydrodipicolinate synthase; Region: dapA; TIGR00674
755178000057	dimer interface [polypeptide binding]; other site
755178000058	active site
755178000059	catalytic residue [active]
755178000060	mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595
755178000061	Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753
755178000062	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
755178000063	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
755178000064	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
755178000065	dimer interface [polypeptide binding]; other site
755178000066	conserved gate region; other site
755178000067	ABC-ATPase subunit interface; other site
755178000068	hopene-associated glycosyltransferase HpnB; Region: HpnB; TIGR03469
755178000069	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
755178000070	active site
755178000071	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147
755178000072	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113
755178000073	histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037
755178000074	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
755178000075	dimer interface [polypeptide binding]; other site
755178000076	motif 1; other site
755178000077	active site
755178000078	motif 2; other site
755178000079	motif 3; other site
755178000080	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
755178000081	anticodon binding site; other site
755178000082	Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333
755178000083	amphipathic channel; other site
755178000084	Asn-Pro-Ala signature motifs; other site
755178000085	Domain of unknown function (DUF1832); Region: DUF1832; pfam08870
755178000086	RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724
755178000087	RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399
755178000088	Mg2+ transporter (mgtE); Region: mgtE; TIGR00400
755178000089	MgtE intracellular N domain; Region: MgtE_N; smart00924
755178000090	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE.  MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606
755178000091	Divalent cation transporter; Region: MgtE; pfam01769
755178000092	Mg2+ transporter (mgtE); Region: mgtE; TIGR00400
755178000093	MgtE intracellular N domain; Region: MgtE_N; smart00924
755178000094	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE.  MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606
755178000095	Divalent cation transporter; Region: MgtE; pfam01769
755178000096	PsbP; Region: PsbP; pfam01789
755178000097	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
755178000098	active site
755178000099	Domain of unknown function DUF21; Region: DUF21; pfam01595
755178000100	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
755178000101	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
755178000102	Transporter associated domain; Region: CorC_HlyC; smart01091
755178000103	RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724
755178000104	RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399
755178000105	methionine sulfoxide reductase A; Provisional; Region: PRK00058
755178000106	atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243
755178000107	NADH(P)-binding; Region: NAD_binding_10; pfam13460
755178000108	NAD(P) binding site [chemical binding]; other site
755178000109	putative active site [active]
755178000110	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
755178000111	haloacid dehalogenase superfamily, subfamily IA hydrolase, TIGR01548; Region: HAD-SF-IA-hyp1
755178000112	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
755178000113	Family description; Region: UvrD_C_2; pfam13538
755178000114	Family description; Region: UvrD_C_2; pfam13538
755178000115	ribosomal protein S14; Region: rps14; CHL00074
755178000116	MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420
755178000117	trimer interface [polypeptide binding]; other site
755178000118	dimer interface [polypeptide binding]; other site
755178000119	putative active site [active]
755178000120	Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643
755178000121	Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895
755178000122	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
755178000123	ATP binding site [chemical binding]; other site
755178000124	Mg2+ binding site [ion binding]; other site
755178000125	G-X-G motif; other site
755178000126	CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731
755178000127	Response regulator receiver domain; Region: Response_reg; pfam00072
755178000128	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
755178000129	active site
755178000130	phosphorylation site [posttranslational modification]
755178000131	intermolecular recognition site; other site
755178000132	dimerization interface [polypeptide binding]; other site
755178000133	Response regulator receiver domain; Region: Response_reg; pfam00072
755178000134	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
755178000135	active site
755178000136	phosphorylation site [posttranslational modification]
755178000137	intermolecular recognition site; other site
755178000138	dimerization interface [polypeptide binding]; other site
755178000139	imidazoleglycerol-phosphate dehydratase; Region: PLN02800
755178000140	Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914
755178000141	putative active site pocket [active]
755178000142	4-fold oligomerization interface [polypeptide binding]; other site
755178000143	metal binding residues [ion binding]; metal-binding site
755178000144	3-fold/trimer interface [polypeptide binding]; other site
755178000145	BioD-like N-terminal domain of phosphotransacetylase [General function prediction only]; Region: Pta; COG0857
755178000146	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
755178000147	DRTGG domain; Region: DRTGG; pfam07085
755178000148	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
755178000149	Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015
755178000150	dimer interface [polypeptide binding]; other site
755178000151	decamer (pentamer of dimers) interface [polypeptide binding]; other site
755178000152	catalytic triad [active]
755178000153	peroxidatic and resolving cysteines [active]
755178000154	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
755178000155	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
755178000156	Probable transposase; Region: OrfB_IS605; pfam01385
755178000157	Transposase IS200 like; Region: Y1_Tnp; pfam01797
755178000158	Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215
755178000159	CESA_like is  the cellulose synthase superfamily; Region: CESA_like; cd06423
755178000160	DXD motif; other site
755178000161	Protein of unknown function (DUF3318); Region: DUF3318; pfam11780
755178000162	Uncharacterized conserved protein [Function unknown]; Region: COG3349
755178000163	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
755178000164	Uncharacterized conserved protein [Function unknown]; Region: COG3339
755178000165	Predicted glycosyl transferase [General function prediction only]; Region: COG4671
755178000166	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
755178000167	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
755178000168	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
755178000169	Ribosomal protein S6; Region: Ribosomal_S6; pfam01250
755178000170	Domain of unknown function (DUF1818); Region: DUF1818; pfam08848
755178000171	Protein of unknown function (DUF760); Region: DUF760; pfam05542
755178000172	Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661
755178000173	ABC1 family; Region: ABC1; cl17513
755178000174	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
755178000175	Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842
755178000176	Sporulation protein and related proteins [Cell division and chromosome partitioning]; Region: SpoIID; COG2385
755178000177	Stage II sporulation protein; Region: SpoIID; pfam08486
755178000178	1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444
755178000179	Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007
755178000180	TPP-binding site; other site
755178000181	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
755178000182	PYR/PP interface [polypeptide binding]; other site
755178000183	dimer interface [polypeptide binding]; other site
755178000184	TPP binding site [chemical binding]; other site
755178000185	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
755178000186	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
755178000187	TrkA-N domain; Region: TrkA_N; pfam02254
755178000188	Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226
755178000189	TrkA-N domain; Region: TrkA_N; pfam02254
755178000190	magnesium chelatase subunit H; Provisional; Region: PRK12493
755178000191	Domain of unknown function (DUF3479); Region: DUF3479; pfam11965
755178000192	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
755178000193	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
755178000194	Protein of unknown function DUF262; Region: DUF262; pfam03235
755178000195	HNH endonuclease; Region: HNH_2; pfam13391
755178000196	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
755178000197	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
755178000198	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
755178000199	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
755178000200	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
755178000201	ATP-grasp domain; Region: ATP-grasp_4; cl17255
755178000202	Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424
755178000203	IMP binding site; other site
755178000204	dimer interface [polypeptide binding]; other site
755178000205	interdomain contacts; other site
755178000206	partial ornithine binding site; other site
755178000207	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830
755178000208	Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165
755178000209	Tfp pilus assembly protein PilW [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilW; COG4966
755178000210	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
755178000211	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
755178000212	Walker A/P-loop; other site
755178000213	ATP binding site [chemical binding]; other site
755178000214	Q-loop/lid; other site
755178000215	ABC transporter signature motif; other site
755178000216	Walker B; other site
755178000217	D-loop; other site
755178000218	H-loop/switch region; other site
755178000219	ABC transporter; Region: ABC_tran_2; pfam12848
755178000220	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
755178000221	MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554
755178000222	homotrimer interaction site [polypeptide binding]; other site
755178000223	zinc binding site [ion binding]; other site
755178000224	CDP-binding sites; other site
755178000225	D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl17344
755178000226	Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057
755178000227	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044
755178000228	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
755178000229	bile acid transporter; Region: bass; TIGR00841
755178000230	Sodium Bile acid symporter family; Region: SBF; pfam01758
755178000231	chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169
755178000232	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
755178000233	Walker A/P-loop; other site
755178000234	ATP binding site [chemical binding]; other site
755178000235	SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968
755178000236	DNA damage checkpoint protein; Region: LCD1; pfam09798
755178000237	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
755178000238	ABC transporter signature motif; other site
755178000239	Walker B; other site
755178000240	D-loop; other site
755178000241	H-loop/switch region; other site
755178000242	Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116
755178000243	THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715
755178000244	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
755178000245	rod shape-determining protein MreD; Region: shape_MreD; TIGR03426
755178000246	Protein of unknown function (DUF561); Region: DUF561; pfam04481
755178000247	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
755178000248	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
755178000249	dimer interface [polypeptide binding]; other site
755178000250	conserved gate region; other site
755178000251	putative PBP binding loops; other site
755178000252	ABC-ATPase subunit interface; other site
755178000253	aspartate aminotransferase; Provisional; Region: PRK05957
755178000254	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
755178000255	pyridoxal 5'-phosphate binding site [chemical binding]; other site
755178000256	homodimer interface [polypeptide binding]; other site
755178000257	catalytic residue [active]
755178000258	enoyl-(acyl carrier protein) reductase; Validated; Region: PRK07370
755178000259	Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372
755178000260	NAD binding site [chemical binding]; other site
755178000261	homotetramer interface [polypeptide binding]; other site
755178000262	homodimer interface [polypeptide binding]; other site
755178000263	substrate binding site [chemical binding]; other site
755178000264	active site
755178000265	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
755178000266	global nitrogen regulator NtcA, cyanobacterial; Region: NtcA_cyano; TIGR03697
755178000267	ligand binding site [chemical binding]; other site
755178000268	flexible hinge region; other site
755178000269	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
755178000270	putative switch regulator; other site
755178000271	non-specific DNA interactions [nucleotide binding]; other site
755178000272	DNA binding site [nucleotide binding]
755178000273	sequence specific DNA binding site [nucleotide binding]; other site
755178000274	putative cAMP binding site [chemical binding]; other site
755178000275	Uncharacterized protein conserved in bacteria with the myosin-like domain [Function unknown]; Region: COG4372
755178000276	Protein of unknown function (DUF3084); Region: DUF3084; pfam11283
755178000277	Response regulator receiver domain; Region: Response_reg; pfam00072
755178000278	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
755178000279	active site
755178000280	phosphorylation site [posttranslational modification]
755178000281	intermolecular recognition site; other site
755178000282	dimerization interface [polypeptide binding]; other site
755178000283	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
755178000284	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
755178000285	metal binding site [ion binding]; metal-binding site
755178000286	active site
755178000287	I-site; other site
755178000288	PAS domain S-box; Region: sensory_box; TIGR00229
755178000289	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
755178000290	putative active site [active]
755178000291	heme pocket [chemical binding]; other site
755178000292	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
755178000293	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
755178000294	putative active site [active]
755178000295	heme pocket [chemical binding]; other site
755178000296	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
755178000297	putative active site [active]
755178000298	heme pocket [chemical binding]; other site
755178000299	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
755178000300	dimer interface [polypeptide binding]; other site
755178000301	phosphorylation site [posttranslational modification]
755178000302	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
755178000303	ATP binding site [chemical binding]; other site
755178000304	Mg2+ binding site [ion binding]; other site
755178000305	G-X-G motif; other site
755178000306	Response regulator receiver domain; Region: Response_reg; pfam00072
755178000307	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
755178000308	active site
755178000309	phosphorylation site [posttranslational modification]
755178000310	intermolecular recognition site; other site
755178000311	dimerization interface [polypeptide binding]; other site
755178000312	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
755178000313	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
755178000314	Domain of Unknown Function (DUF928); Region: DUF928; pfam06051
755178000315	Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805
755178000316	Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131
755178000317	Walker A motif; other site
755178000318	ATP binding site [chemical binding]; other site
755178000319	Walker B motif; other site
755178000320	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
755178000321	active site
755178000322	Protein of unknown function (DUF3531); Region: DUF3531; pfam12049
755178000323	Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040
755178000324	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
755178000325	active site
755178000326	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
755178000327	Major Facilitator Superfamily; Region: MFS_1; pfam07690
755178000328	putative substrate translocation pore; other site
755178000329	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
755178000330	dihydropteroate synthase; Region: DHPS; TIGR01496
755178000331	substrate binding pocket [chemical binding]; other site
755178000332	dimer interface [polypeptide binding]; other site
755178000333	inhibitor binding site; inhibition site
755178000334	triosephosphate isomerase; Provisional; Region: PRK14565
755178000335	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
755178000336	substrate binding site [chemical binding]; other site
755178000337	dimer interface [polypeptide binding]; other site
755178000338	catalytic triad [active]
755178000339	acetolactate synthase; Reviewed; Region: PRK08322
755178000340	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
755178000341	PYR/PP interface [polypeptide binding]; other site
755178000342	dimer interface [polypeptide binding]; other site
755178000343	TPP binding site [chemical binding]; other site
755178000344	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
755178000345	Thiamine pyrophosphate (TPP) family, Acetolactate synthase (ALS) subfamily, TPP-binding module; composed of proteins similar to Klebsiella pneumoniae ALS, a catabolic enzyme required for butanediol fermentation. ALS catalyzes the conversion of 2...; Region: TPP_ALS; cd02010
755178000346	TPP-binding site [chemical binding]; other site
755178000347	dimer interface [polypeptide binding]; other site
755178000348	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
755178000349	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
755178000350	active site
755178000351	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807
755178000352	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364
755178000353	Streptogramin lyase [Defense mechanisms]; Region: Vgb; COG4257
755178000354	CpeS-like protein; Region: CpeS; pfam09367
755178000355	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
755178000356	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
755178000357	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
755178000358	Cytochrome P450; Region: p450; cl12078
755178000359	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
755178000360	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3146
755178000361	Protein of unknown function, DUF482; Region: DUF482; pfam04339
755178000362	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
755178000363	catalytic core [active]
755178000364	citrate synthase; Provisional; Region: PRK14036
755178000365	Citrate synthase (CS) catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the oxidative citric acid cycle (TCA or Krebs cycle). Peroxisomal CS is involved in the glyoxylate...; Region: citrate_synt_like_1_1; cd06112
755178000366	dimer interface [polypeptide binding]; other site
755178000367	active site
755178000368	citrylCoA binding site [chemical binding]; other site
755178000369	oxalacetate/citrate binding site [chemical binding]; other site
755178000370	coenzyme A binding site [chemical binding]; other site
755178000371	catalytic triad [active]
755178000372	hypothetical protein; Validated; Region: PRK00041
755178000373	S-layer homology domain; Region: SLH; pfam00395
755178000374	Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966
755178000375	NAD synthetase; Provisional; Region: PRK13981
755178000376	Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570
755178000377	multimer interface [polypeptide binding]; other site
755178000378	active site
755178000379	catalytic triad [active]
755178000380	protein interface 1 [polypeptide binding]; other site
755178000381	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
755178000382	homodimer interface [polypeptide binding]; other site
755178000383	NAD binding pocket [chemical binding]; other site
755178000384	ATP binding pocket [chemical binding]; other site
755178000385	Mg binding site [ion binding]; other site
755178000386	active-site loop [active]
755178000387	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
755178000388	atypical (a) SDRs, subgroup 1; Region: SDR_a1; cd05265
755178000389	putative NAD(P) binding site [chemical binding]; other site
755178000390	active site
755178000391	UDP-glucose 4-epimerase C-term subunit; Region: Epimerase_Csub; pfam13950
755178000392	bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II/unknown domain fusion protein; Provisional; Region: PRK09319
755178000393	3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926
755178000394	GTP cyclohydrolase II (RibA).  GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641
755178000395	dimerization interface [polypeptide binding]; other site
755178000396	active site
755178000397	ammonium transporter; Region: amt; TIGR00836
755178000398	Ion channel; Region: Ion_trans_2; pfam07885
755178000399	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
755178000400	TrkA-N domain; Region: TrkA_N; pfam02254
755178000401	TrkA-C domain; Region: TrkA_C; pfam02080
755178000402	Predicted metal-binding protein (DUF2103); Region: DUF2103; cl01651
755178000403	ATP-dependent Clp protease adaptor; Reviewed; Region: clpS; PRK13019
755178000404	asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932
755178000405	EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318
755178000406	putative dimer interface [polypeptide binding]; other site
755178000407	putative anticodon binding site; other site
755178000408	Asx tRNA synthetase (AspRS/AsnRS) class II core domain.  Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776
755178000409	homodimer interface [polypeptide binding]; other site
755178000410	motif 1; other site
755178000411	motif 2; other site
755178000412	active site
755178000413	motif 3; other site
755178000414	tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282
755178000415	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
755178000416	active site
755178000417	HIGH motif; other site
755178000418	dimer interface [polypeptide binding]; other site
755178000419	KMSKS motif; other site
755178000420	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537
755178000421	FAD binding site [chemical binding]; other site
755178000422	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
755178000423	Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723
755178000424	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467
755178000425	iron-sulfur cluster [ion binding]; other site
755178000426	[2Fe-2S] cluster binding site [ion binding]; other site
755178000427	Uncharacterized conserved protein [Function unknown]; Region: COG3349
755178000428	glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062
755178000429	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
755178000430	inhibitor-cofactor binding pocket; inhibition site
755178000431	pyridoxal 5'-phosphate binding site [chemical binding]; other site
755178000432	catalytic residue [active]
755178000433	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
755178000434	anti sigma factor interaction site; other site
755178000435	regulatory phosphorylation site [posttranslational modification]; other site
755178000436	Bacterial SH3 domain; Region: SH3_3; cl17532
755178000437	haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509
755178000438	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
755178000439	active site
755178000440	motif I; other site
755178000441	motif II; other site
755178000442	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
755178000443	Major Facilitator Superfamily; Region: MFS_1; pfam07690
755178000444	putative substrate translocation pore; other site
755178000445	Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354
755178000446	PUCC protein; Region: PUCC; pfam03209
755178000447	Bacterial family of Mg++ dependent phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate inositol monophosphate or similar substrates; Region: Bacterial_IMPase_like_2; cd01643
755178000448	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
755178000449	active site
755178000450	undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726
755178000451	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
755178000452	active site
755178000453	homodimer interface [polypeptide binding]; other site
755178000454	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
755178000455	S-adenosylmethionine binding site [chemical binding]; other site
755178000456	ubiquinone biosynthesis methyltransferase; Region: PLN02232
755178000457	Lipid A disaccharide synthetase [Cell envelope biogenesis, outer membrane]; Region: LpxB; COG0763
755178000458	Domain of unknown function (DUF4327); Region: DUF4327; pfam14217
755178000459	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
755178000460	putative lipid kinase; Reviewed; Region: PRK13057
755178000461	ribosomal protein L33; Region: rpl33; CHL00104
755178000462	30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391
755178000463	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
755178000464	23S rRNA interface [nucleotide binding]; other site
755178000465	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
755178000466	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
755178000467	peripheral dimer interface [polypeptide binding]; other site
755178000468	core dimer interface [polypeptide binding]; other site
755178000469	L10 interface [polypeptide binding]; other site
755178000470	L11 interface [polypeptide binding]; other site
755178000471	putative EF-Tu interaction site [polypeptide binding]; other site
755178000472	putative EF-G interaction site [polypeptide binding]; other site
755178000473	Protein of unknown function (DUF3153); Region: DUF3153; pfam11353
755178000474	Sporulation and spore germination; Region: Germane; pfam10646
755178000475	Protein of unknown function (DUF2993); Region: DUF2993; pfam11209
755178000476	Response regulator receiver domain; Region: Response_reg; pfam00072
755178000477	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
755178000478	active site
755178000479	phosphorylation site [posttranslational modification]
755178000480	intermolecular recognition site; other site
755178000481	dimerization interface [polypeptide binding]; other site
755178000482	PAS domain S-box; Region: sensory_box; TIGR00229
755178000483	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
755178000484	putative active site [active]
755178000485	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
755178000486	PAS domain; Region: PAS_9; pfam13426
755178000487	putative active site [active]
755178000488	heme pocket [chemical binding]; other site
755178000489	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
755178000490	metal binding site [ion binding]; metal-binding site
755178000491	active site
755178000492	I-site; other site
755178000493	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
755178000494	Bacterial conjugation TrbI-like protein; Region: TrbI; cl04242
755178000495	Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042
755178000496	CoA binding domain; Region: CoA_binding_2; pfam13380
755178000497	Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607
755178000498	ATP-grasp domain; Region: ATP-grasp_5; pfam13549
755178000499	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
755178000500	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
755178000501	Coenzyme A binding pocket [chemical binding]; other site
755178000502	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
755178000503	Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535
755178000504	active site
755178000505	Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632
755178000506	Serine acetyltransferase [Amino acid transport and metabolism]; Region: CysE; COG1045
755178000507	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
755178000508	trimer interface [polypeptide binding]; other site
755178000509	active site
755178000510	substrate binding site [chemical binding]; other site
755178000511	CoA binding site [chemical binding]; other site
755178000512	Peroxiredoxin (PRX)-like 1 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a conserved cysteine that aligns to the first cysteine in the CXXC motif of TRX. This does not correspond to the peroxidatic...; Region: PRX_like1; cd02969
755178000513	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
755178000514	putative catalytic residue [active]
755178000515	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
755178000516	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
755178000517	dimerization interface [polypeptide binding]; other site
755178000518	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
755178000519	dimer interface [polypeptide binding]; other site
755178000520	phosphorylation site [posttranslational modification]
755178000521	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
755178000522	ATP binding site [chemical binding]; other site
755178000523	Mg2+ binding site [ion binding]; other site
755178000524	G-X-G motif; other site
755178000525	pyruvate kinase; Provisional; Region: PRK06354
755178000526	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
755178000527	domain interfaces; other site
755178000528	active site
755178000529	Phosphohistidine swiveling domain [Signal transduction mechanisms]; Region: COG3848
755178000530	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
755178000531	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
755178000532	non-specific DNA binding site [nucleotide binding]; other site
755178000533	salt bridge; other site
755178000534	sequence-specific DNA binding site [nucleotide binding]; other site
755178000535	KH domain; Region: KH_4; pfam13083
755178000536	ribosomal protein S16; Region: rps16; CHL00005
755178000537	HisA.  Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732
755178000538	phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007
755178000539	catalytic residues [active]
755178000540	Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435
755178000541	Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409
755178000542	C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190
755178000543	putative dimer interface [polypeptide binding]; other site
755178000544	N-terminal domain interface [polypeptide binding]; other site
755178000545	putative substrate binding pocket (H-site) [chemical binding]; other site
755178000546	Uncharacterized protein, putative amidase [General function prediction only]; Region: COG1402
755178000547	Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572
755178000548	nitrilase; Region: PLN02798
755178000549	putative active site [active]
755178000550	catalytic triad [active]
755178000551	dimer interface [polypeptide binding]; other site
755178000552	arogenate dehydrogenase; Reviewed; Region: PRK07417
755178000553	prephenate dehydrogenase; Validated; Region: PRK08507
755178000554	light-dependent protochlorophyllide reductase; Region: LPOR; TIGR01289
755178000555	light-dependent protochlorophyllide reductase (LPOR)-like, classical (c)-like SDRs; Region: LPOR_like_SDR_c_like; cd09810
755178000556	putative NAD(P) binding site [chemical binding]; other site
755178000557	active site
755178000558	phosphoglyceromutase; Provisional; Region: PRK05434
755178000559	Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696
755178000560	2-phosphosulfolactate phosphatase; Provisional; Region: PRK00886
755178000561	Phosphosulfolactate phosphohydrolase and related enzymes [Coenzyme metabolism / General function prediction only]; Region: COG2045
755178000562	Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312
755178000563	Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419
755178000564	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915
755178000565	active site
755178000566	motif I; other site
755178000567	motif II; other site
755178000568	Lecithin retinol acyltransferase; Region: LRAT; pfam04970
755178000569	Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842
755178000570	cobalt ABC transporter, permease protein CbiQ; Region: CbiQ_TIGR; TIGR02454
755178000571	Cyanobacterial and plastid NDH-1 subunit M; Region: NdhM; pfam10664
755178000572	Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239
755178000573	Beta-carotene hydroxylase (CrtR), the carotenoid zeaxanthin biosynthetic enzyme catalyzes the addition of hydroxyl groups to the beta-ionone rings of beta-carotene to form zeaxanthin and is found in bacteria and red algae. Carotenoids are important...; Region: CrtR_beta-carotene-hydroxylase; cd03514
755178000574	putative di-iron ligands [ion binding]; other site
755178000575	50S ribosomal protein L19; Provisional; Region: rplS; PRK05338
755178000576	preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597
755178000577	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
755178000578	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
755178000579	putative homodimer interface [polypeptide binding]; other site
755178000580	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
755178000581	heterodimer interface [polypeptide binding]; other site
755178000582	homodimer interface [polypeptide binding]; other site
755178000583	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
755178000584	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
755178000585	23S rRNA interface [nucleotide binding]; other site
755178000586	L7/L12 interface [polypeptide binding]; other site
755178000587	putative thiostrepton binding site; other site
755178000588	L25 interface [polypeptide binding]; other site
755178000589	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
755178000590	mRNA/rRNA interface [nucleotide binding]; other site
755178000591	Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548
755178000592	FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831
755178000593	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
755178000594	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
755178000595	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
755178000596	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
755178000597	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
755178000598	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
755178000599	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
755178000600	Walker A/P-loop; other site
755178000601	ATP binding site [chemical binding]; other site
755178000602	Q-loop/lid; other site
755178000603	ABC transporter signature motif; other site
755178000604	Walker B; other site
755178000605	D-loop; other site
755178000606	H-loop/switch region; other site
755178000607	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316
755178000608	JmjC domain, hydroxylase; Region: JmjC; pfam02373
755178000609	Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307
755178000610	O-Antigen ligase; Region: Wzy_C; pfam04932
755178000611	Integrin alpha (beta-propellor repeats); Region: Int_alpha; smart00191
755178000612	Integrin alpha (beta-propellor repeats); Region: Int_alpha; smart00191
755178000613	Integrin alpha (beta-propellor repeats); Region: Int_alpha; smart00191
755178000614	Integrin alpha (beta-propellor repeats); Region: Int_alpha; smart00191
755178000615	Domains in Na-Ca exchangers and integrin-beta4; Region: Calx_beta; smart00237
755178000616	riboflavin synthase subunit alpha; Provisional; Region: PRK09289
755178000617	Lumazine binding domain; Region: Lum_binding; pfam00677
755178000618	Lumazine binding domain; Region: Lum_binding; pfam00677
755178000619	Protein of unknown function (DUF3288); Region: DUF3288; pfam11691
755178000620	glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK02862
755178000621	ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508
755178000622	ligand binding site; other site
755178000623	oligomer interface; other site
755178000624	Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651
755178000625	dimer interface [polypeptide binding]; other site
755178000626	N-terminal domain interface [polypeptide binding]; other site
755178000627	sulfate 1 binding site; other site
755178000628	Uncharacterized protein conserved in bacteria (DUF2191); Region: DUF2191; pfam09957
755178000629	tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037
755178000630	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
755178000631	Ligand Binding Site [chemical binding]; other site
755178000632	Protein of unknown function (DUF2288); Region: DUF2288; pfam10052
755178000633	DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450
755178000634	pyridoxal 5'-phosphate binding site [chemical binding]; other site
755178000635	catalytic residue [active]
755178000636	glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352
755178000637	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
755178000638	Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728
755178000639	ThiS interaction site; other site
755178000640	putative active site [active]
755178000641	tetramer interface [polypeptide binding]; other site
755178000642	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
755178000643	active site
755178000644	catalytic residues [active]
755178000645	metal binding site [ion binding]; metal-binding site
755178000646	hypothetical protein; Validated; Region: PRK00153
755178000647	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
755178000648	Low molecular weight phosphatase family; Region: LMWPc; cd00115
755178000649	active site
755178000650	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
755178000651	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
755178000652	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
755178000653	Walker A/P-loop; other site
755178000654	ATP binding site [chemical binding]; other site
755178000655	Q-loop/lid; other site
755178000656	ABC transporter signature motif; other site
755178000657	Walker B; other site
755178000658	D-loop; other site
755178000659	H-loop/switch region; other site
755178000660	Major Facilitator Superfamily; Region: MFS_1; pfam07690
755178000661	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
755178000662	putative substrate translocation pore; other site
755178000663	CO2 hydration protein (ChpXY); Region: ChpXY; pfam10216
755178000664	Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412
755178000665	BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840
755178000666	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
755178000667	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
755178000668	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
755178000669	ribosomal protein S4; Reviewed; Region: rps4; CHL00113
755178000670	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
755178000671	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
755178000672	RNA binding surface [nucleotide binding]; other site
755178000673	formamidopyrimidine-DNA glycosylase; Provisional; Region: PRK13945
755178000674	N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966
755178000675	DNA binding site [nucleotide binding]
755178000676	catalytic residue [active]
755178000677	H2TH interface [polypeptide binding]; other site
755178000678	putative catalytic residues [active]
755178000679	turnover-facilitating residue; other site
755178000680	intercalation triad [nucleotide binding]; other site
755178000681	8OG recognition residue [nucleotide binding]; other site
755178000682	putative reading head residues; other site
755178000683	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
755178000684	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
755178000685	photosystem I reaction center subunit IV; Provisional; Region: PRK02749
755178000686	Transposase IS200 like; Region: Y1_Tnp; cl00848
755178000687	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
755178000688	This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809
755178000689	methionyl-tRNA synthetase; Reviewed; Region: PRK11893
755178000690	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
755178000691	active site
755178000692	HIGH motif; other site
755178000693	KMSKS motif; other site
755178000694	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
755178000695	anticodon binding site; other site
755178000696	tRNA binding surface [nucleotide binding]; other site
755178000697	Uncharacterized conserved protein [Function unknown]; Region: COG1432
755178000698	LabA_like proteins; Region: LabA; cd10911
755178000699	putative metal binding site [ion binding]; other site
755178000700	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
755178000701	DnaB-like helicase C terminal domain; Region: DnaB_C; pfam03796
755178000702	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
755178000703	Walker A motif; other site
755178000704	ATP binding site [chemical binding]; other site
755178000705	Walker B motif; other site
755178000706	DNA binding loops [nucleotide binding]
755178000707	Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081
755178000708	protein-splicing catalytic site; other site
755178000709	thioester formation/cholesterol transfer; other site
755178000710	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
755178000711	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
755178000712	transketolase; Region: PLN02790
755178000713	TPP-binding site [chemical binding]; other site
755178000714	dimer interface [polypeptide binding]; other site
755178000715	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
755178000716	PYR/PP interface [polypeptide binding]; other site
755178000717	dimer interface [polypeptide binding]; other site
755178000718	TPP binding site [chemical binding]; other site
755178000719	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
755178000720	Repair protein; Region: Repair_PSII; pfam04536
755178000721	Uncharacterized protein family (UPF0150); Region: UPF0150; cl00691
755178000722	YcfA-like protein; Region: YcfA; pfam07927
755178000723	phycobillisome linker protein; Region: apcE; CHL00091
755178000724	Phycobilisome protein; Region: Phycobilisome; cl08227
755178000725	Phycobilisome protein; Region: Phycobilisome; cl08227
755178000726	Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427
755178000727	Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427
755178000728	Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427
755178000729	Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384
755178000730	dimer interface [polypeptide binding]; other site
755178000731	active site
755178000732	Schiff base residues; other site
755178000733	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
755178000734	Catalytic domain of Protein Kinases; Region: PKc; cd00180
755178000735	active site
755178000736	ATP binding site [chemical binding]; other site
755178000737	substrate binding site [chemical binding]; other site
755178000738	activation loop (A-loop); other site
755178000739	Uncharacterized conserved protein [Function unknown]; Region: COG1434
755178000740	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
755178000741	putative active site [active]
755178000742	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
755178000743	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
755178000744	Sulfate transporter family; Region: Sulfate_transp; pfam00916
755178000745	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
755178000746	Uncharacterized BCR, COG1649; Region: DUF187; pfam02638
755178000747	putative hydrolase, CocE/NonD family; Region: /NonD; TIGR00976
755178000748	X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939
755178000749	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
755178000750	CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492
755178000751	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683
755178000752	UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472
755178000753	This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853
755178000754	Mg++ binding site [ion binding]; other site
755178000755	putative catalytic motif [active]
755178000756	substrate binding site [chemical binding]; other site
755178000757	photosystem I reaction center subunit IX; Provisional; Region: PRK02733
755178000758	Photosystem I reaction centre subunit III; Region: PSI_PsaF; cl03627
755178000759	UGMP family protein; Validated; Region: PRK09604
755178000760	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
755178000761	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
755178000762	HSP70 interaction site [polypeptide binding]; other site
755178000763	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
755178000764	TPR repeat; Region: TPR_11; pfam13414
755178000765	binding surface
755178000766	TPR motif; other site
755178000767	ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12292
755178000768	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
755178000769	dimer interface [polypeptide binding]; other site
755178000770	motif 1; other site
755178000771	active site
755178000772	motif 2; other site
755178000773	motif 3; other site
755178000774	Uncharacterized ABC-type transport system, permease components [General function prediction only]; Region: COG3932
755178000775	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
755178000776	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
755178000777	active site
755178000778	catalytic tetrad [active]
755178000779	Protein of unknown function (DUF2993); Region: DUF2993; pfam11209
755178000780	argininosuccinate lyase; Provisional; Region: PRK00855
755178000781	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
755178000782	active sites [active]
755178000783	tetramer interface [polypeptide binding]; other site
755178000784	Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020
755178000785	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475
755178000786	catalytic residue [active]
755178000787	putative FPP diphosphate  binding site; other site
755178000788	putative FPP binding hydrophobic cleft; other site
755178000789	dimer interface [polypeptide binding]; other site
755178000790	putative IPP diphosphate binding site; other site
755178000791	single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644
755178000792	DHH family; Region: DHH; pfam01368
755178000793	thiamine biosynthesis protein ThiC; Provisional; Region: PRK13352
755178000794	thiamine biosynthesis protein ThiC; Region: thiC; TIGR00190
755178000795	Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577
755178000796	Carbon dioxide concentrating mechanism (CcmK); Bacterial Micro-Compartment (BCM) domain; Region: BMC_CcmK; cd07057
755178000797	Hexamer interface [polypeptide binding]; other site
755178000798	Hexagonal pore residue; other site
755178000799	Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577
755178000800	Carbon dioxide concentrating mechanism (CcmK); Bacterial Micro-Compartment (BCM) domain; Region: BMC_CcmK; cd07057
755178000801	Hexamer interface [polypeptide binding]; other site
755178000802	Hexagonal pore residue; other site
755178000803	Protein of unknown function (DUF3143); Region: DUF3143; pfam11341
755178000804	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
755178000805	DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]; Region: DnaJ; COG0484
755178000806	HSP70 interaction site [polypeptide binding]; other site
755178000807	DNA topoisomerase I subunit omega; Validated; Region: PRK07561
755178000808	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363
755178000809	active site
755178000810	interdomain interaction site; other site
755178000811	putative metal-binding site [ion binding]; other site
755178000812	nucleotide binding site [chemical binding]; other site
755178000813	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
755178000814	domain I; other site
755178000815	DNA binding groove [nucleotide binding]
755178000816	phosphate binding site [ion binding]; other site
755178000817	domain II; other site
755178000818	domain III; other site
755178000819	nucleotide binding site [chemical binding]; other site
755178000820	catalytic site [active]
755178000821	domain IV; other site
755178000822	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
755178000823	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
755178000824	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
755178000825	Putative ammonia monooxygenase; Region: AmoA; pfam05145
755178000826	membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082
755178000827	membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082
755178000828	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
755178000829	DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674
755178000830	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
755178000831	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
755178000832	active site
755178000833	NTP binding site [chemical binding]; other site
755178000834	metal binding triad [ion binding]; metal-binding site
755178000835	antibiotic binding site [chemical binding]; other site
755178000836	Protein of unknown function DUF86; Region: DUF86; cl01031
755178000837	Calx-beta domain; Region: Calx-beta; cl02522
755178000838	YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486
755178000839	generic binding surface I; other site
755178000840	generic binding surface II; other site
755178000841	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
755178000842	putative catalytic site [active]
755178000843	putative metal binding site [ion binding]; other site
755178000844	putative phosphate binding site [ion binding]; other site
755178000845	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
755178000846	putative metal binding site [ion binding]; other site
755178000847	Esterase-like activity of phytase; Region: Phytase-like; pfam13449
755178000848	CHRD domain; Region: CHRD; pfam07452
755178000849	Bacterial protein of unknown function (DUF839); Region: DUF839; pfam05787
755178000850	5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737
755178000851	Synechococcus sp. strain PCC 7942  PhoA and related proteins, N-terminal metallophosphatase domain; Region: MPP_PhoA_N; cd08162
755178000852	putative active site [active]
755178000853	putative metal binding site [ion binding]; other site
755178000854	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
755178000855	pyridoxamine-phosphate oxidase; Region: pdxH; TIGR00558
755178000856	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
755178000857	Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590
755178000858	ferredoxin-nitrite reductase; Reviewed; Region: nirA; PRK09566
755178000859	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
755178000860	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
755178000861	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
755178000862	Transglutaminase family, C-terminal ig like domain; Region: Transglut_C; pfam00927
755178000863	Domain of unknown function (DUF4114); Region: DUF4114; pfam13448
755178000864	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
755178000865	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
755178000866	dimer interface [polypeptide binding]; other site
755178000867	conserved gate region; other site
755178000868	putative PBP binding loops; other site
755178000869	ABC-ATPase subunit interface; other site
755178000870	porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072
755178000871	Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494
755178000872	domain interfaces; other site
755178000873	active site
755178000874	dephospho-CoA kinase; Region: TIGR00152
755178000875	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
755178000876	CoA-binding site [chemical binding]; other site
755178000877	ATP-binding [chemical binding]; other site
755178000878	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
755178000879	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
755178000880	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
755178000881	Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535
755178000882	active site
755178000883	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
755178000884	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
755178000885	active site
755178000886	HIGH motif; other site
755178000887	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
755178000888	active site
755178000889	KMSKS motif; other site
755178000890	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
755178000891	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
755178000892	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
755178000893	Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692
755178000894	Protein of unknown function (DUF565); Region: DUF565; pfam04483
755178000895	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4370
755178000896	conserved hypothetical protein; Region: TIGR03492
755178000897	Hemerythrin; Region: Hemerythrin; cd12107
755178000898	Fe binding site [ion binding]; other site
755178000899	Domain of unknown function (DUF4346); Region: DUF4346; pfam14251
755178000900	Phycobilisome protein; Region: Phycobilisome; cl08227
755178000901	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
755178000902	Catalytic domain of Protein Kinases; Region: PKc; cd00180
755178000903	active site
755178000904	ATP binding site [chemical binding]; other site
755178000905	substrate binding site [chemical binding]; other site
755178000906	activation loop (A-loop); other site
755178000907	Predicted oxidoreductases of the aldo/keto reductase family [General function prediction only]; Region: COG1453
755178000908	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
755178000909	active site
755178000910	catalytic tetrad [active]
755178000911	Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357
755178000912	16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107
755178000913	Phosphorylase superfamily; Region: PNP_UDP_1; cl00303
755178000914	glycogen branching enzyme; Provisional; Region: PRK12313
755178000915	N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855
755178000916	Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322
755178000917	active site
755178000918	catalytic site [active]
755178000919	Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806
755178000920	Protein of unknown function (DUF497); Region: DUF497; cl01108
755178000921	O-succinylbenzoic acid--CoA ligase; Reviewed; Region: PRK07445
755178000922	O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912
755178000923	acyl-activating enzyme (AAE) consensus motif; other site
755178000924	putative AMP binding site [chemical binding]; other site
755178000925	putative active site [active]
755178000926	putative CoA binding site [chemical binding]; other site
755178000927	GTPase SAR1 and related small G proteins [General function prediction only]; Region: COG1100
755178000928	E. coli Ras-like protein (Era)-like GTPase; Region: Era_like; cd00880
755178000929	G1 box; other site
755178000930	GTP/Mg2+ binding site [chemical binding]; other site
755178000931	Switch I region; other site
755178000932	G2 box; other site
755178000933	Switch II region; other site
755178000934	G3 box; other site
755178000935	G4 box; other site
755178000936	G5 box; other site
755178000937	Domain of unknown function (DUF697); Region: DUF697; pfam05128
755178000938	TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122
755178000939	Protein of unknown function (DUF3011); Region: DUF3011; pfam11218
755178000940	Predicted permeases [General function prediction only]; Region: COG0701
755178000941	Domain of unknown function (DUF1980); Region: DUF1980; cl01492
755178000942	isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437
755178000943	Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811
755178000944	homotetramer interface [polypeptide binding]; other site
755178000945	FMN binding site [chemical binding]; other site
755178000946	homodimer contacts [polypeptide binding]; other site
755178000947	putative active site [active]
755178000948	putative substrate binding site [chemical binding]; other site
755178000949	D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429
755178000950	D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666
755178000951	Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750
755178000952	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
755178000953	active site
755178000954	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
755178000955	protein binding site [polypeptide binding]; other site
755178000956	Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020
755178000957	photosystem I subunit VII; Region: psaC; CHL00065
755178000958	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
755178000959	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
755178000960	homotrimer interaction site [polypeptide binding]; other site
755178000961	putative active site [active]
755178000962	Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578
755178000963	Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730
755178000964	Heterodisulfide reductase, subunit B [Energy production and conversion]; Region: HdrB; COG2048
755178000965	Cysteine-rich domain; Region: CCG; pfam02754
755178000966	Cysteine-rich domain; Region: CCG; pfam02754
755178000967	SGNH_hydrolase subfamily. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site...; Region: SGNH_hydrolase_like_3; cd01835
755178000968	active site
755178000969	catalytic triad [active]
755178000970	oxyanion hole [active]
755178000971	Cache domain; Region: Cache_1; pfam02743
755178000972	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
755178000973	dimerization interface [polypeptide binding]; other site
755178000974	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
755178000975	PAS domain; Region: PAS_9; pfam13426
755178000976	putative active site [active]
755178000977	heme pocket [chemical binding]; other site
755178000978	Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208
755178000979	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
755178000980	L,L-diaminopimelate aminotransferase; Validated; Region: PRK07590
755178000981	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
755178000982	pyridoxal 5'-phosphate binding site [chemical binding]; other site
755178000983	homodimer interface [polypeptide binding]; other site
755178000984	catalytic residue [active]
755178000985	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
755178000986	S-adenosylmethionine binding site [chemical binding]; other site
755178000987	Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637
755178000988	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
755178000989	motif II; other site
755178000990	radical SAM/Cys-rich domain protein; Region: rSAM_SeCys; TIGR04167
755178000991	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
755178000992	FeS/SAM binding site; other site
755178000993	Domain of unknown function (DUF4281); Region: DUF4281; pfam14108
755178000994	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
755178000995	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
755178000996	The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; Region: BAR; cl12013
755178000997	HlyD family secretion protein; Region: HlyD_3; pfam13437
755178000998	C-20 methyltransferase BchU; Region: C20_methyl_CrtF; TIGR02716
755178000999	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
755178001000	S-adenosylmethionine binding site [chemical binding]; other site
755178001001	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
755178001002	binding surface
755178001003	TPR repeat; Region: TPR_11; pfam13414
755178001004	TPR motif; other site
755178001005	TPR repeat; Region: TPR_11; pfam13414
755178001006	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
755178001007	TPR motif; other site
755178001008	binding surface
755178001009	TPR repeat; Region: TPR_11; pfam13414
755178001010	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
755178001011	binding surface
755178001012	TPR motif; other site
755178001013	TPR repeat; Region: TPR_11; pfam13414
755178001014	DnaJ domain; Region: DnaJ; pfam00226
755178001015	HSP70 interaction site [polypeptide binding]; other site
755178001016	Protein of unknown function (DUF4101); Region: DUF4101; pfam13355
755178001017	Phosphotransferase enzyme family; Region: APH; pfam01636
755178001018	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
755178001019	active site
755178001020	ATP binding site [chemical binding]; other site
755178001021	Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992
755178001022	Transcriptional regulator [Transcription]; Region: LysR; COG0583
755178001023	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
755178001024	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
755178001025	dimerization interface [polypeptide binding]; other site
755178001026	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
755178001027	Catalytic domain of Protein Kinases; Region: PKc; cd00180
755178001028	active site
755178001029	ATP binding site [chemical binding]; other site
755178001030	substrate binding site [chemical binding]; other site
755178001031	activation loop (A-loop); other site
755178001032	GUN4-like; Region: GUN4; pfam05419
755178001033	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
755178001034	polysaccharide export protein EpsE; Region: EpsE; TIGR03028
755178001035	SLBB domain; Region: SLBB; pfam10531
755178001036	tRNA guanosine-2'-O-methyltransferase; Provisional; Region: PRK11081
755178001037	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
755178001038	SpoU, rRNA methylase, C-terminal; Region: SpoU_methylas_C; pfam12105
755178001039	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
755178001040	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
755178001041	catalytic loop [active]
755178001042	iron binding site [ion binding]; other site
755178001043	Uncharacterized ACR, YggU family COG1872; Region: DUF167; pfam02594
755178001044	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
755178001045	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
755178001046	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
755178001047	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
755178001048	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
755178001049	Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606
755178001050	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
755178001051	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
755178001052	Walker A motif; other site
755178001053	ATP binding site [chemical binding]; other site
755178001054	Walker B motif; other site
755178001055	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335
755178001056	Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197
755178001057	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
755178001058	CarD-like/TRCF domain; Region: CarD_TRCF; smart01058
755178001059	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
755178001060	ATP binding site [chemical binding]; other site
755178001061	putative Mg++ binding site [ion binding]; other site
755178001062	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
755178001063	nucleotide binding region [chemical binding]; other site
755178001064	ATP-binding site [chemical binding]; other site
755178001065	This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982
755178001066	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
755178001067	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
755178001068	putative acyl-acceptor binding pocket; other site
755178001069	D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429
755178001070	Protein of unknown function (DUF3110); Region: DUF3110; pfam11360
755178001071	N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441
755178001072	N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007
755178001073	putative active site [active]
755178001074	Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_2; cd06160
755178001075	Peptidase family M50; Region: Peptidase_M50; pfam02163
755178001076	active site
755178001077	putative substrate binding region [chemical binding]; other site
755178001078	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
755178001079	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
755178001080	Probable transposase; Region: OrfB_IS605; pfam01385
755178001081	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
755178001082	Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641
755178001083	active site
755178001084	SAM binding site [chemical binding]; other site
755178001085	homodimer interface [polypeptide binding]; other site
755178001086	Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231
755178001087	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883
755178001088	nudix motif; other site
755178001089	CAAX protease self-immunity; Region: Abi; pfam02517
755178001090	Alpha/beta hydrolase of unknown function (DUF1400); Region: DUF1400; pfam07176
755178001091	Predicted dienelactone hydrolase [General function prediction only]; Region: COG4188
755178001092	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
755178001093	ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259
755178001094	Walker A/P-loop; other site
755178001095	ATP binding site [chemical binding]; other site
755178001096	Q-loop/lid; other site
755178001097	ABC transporter signature motif; other site
755178001098	Walker B; other site
755178001099	D-loop; other site
755178001100	H-loop/switch region; other site
755178001101	TOBE domain; Region: TOBE_2; pfam08402
755178001102	ncharacterized protein conserved in bacteria [Function unknown]; Region: SpoIIIAA; COG3854
755178001103	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
755178001104	Walker A motif; other site
755178001105	ATP binding site [chemical binding]; other site
755178001106	Walker B motif; other site
755178001107	R3H domain of a group of proteins with unknown function, who also contain a AAA-ATPase (AAA) domain. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine and histidine residues. The function of the domain is...; Region: R3H_AAA; cd02645
755178001108	RxxxH motif; other site
755178001109	Predicted transcriptional regulators [Transcription]; Region: COG1725
755178001110	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
755178001111	DNA-binding site [nucleotide binding]; DNA binding site
755178001112	Domain of unknown function (DUF4308); Region: DUF4308; pfam14159
755178001113	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
755178001114	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
755178001115	Catalytic site [active]
755178001116	Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702
755178001117	PhoH-like protein; Region: PhoH; pfam02562
755178001118	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
755178001119	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
755178001120	phosphopeptide binding site; other site
755178001121	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
755178001122	6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400
755178001123	putative active site [active]
755178001124	Helicase C-terminal domain; Region: Helicase_C_2; pfam13307
755178001125	Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644
755178001126	active site
755178001127	putative homodimer interface [polypeptide binding]; other site
755178001128	SAM binding site [chemical binding]; other site
755178001129	Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242
755178001130	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
755178001131	S-adenosylmethionine binding site [chemical binding]; other site
755178001132	adenosine nucleotide hydrolase NudE; Provisional; Region: nudE; PRK11762
755178001133	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
755178001134	dimer interface [polypeptide binding]; other site
755178001135	ADP-ribose binding site [chemical binding]; other site
755178001136	active site
755178001137	nudix motif; other site
755178001138	metal binding site [ion binding]; metal-binding site
755178001139	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
755178001140	Domain of unknown function DUF20; Region: UPF0118; pfam01594
755178001141	Response regulator receiver domain; Region: Response_reg; pfam00072
755178001142	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
755178001143	active site
755178001144	phosphorylation site [posttranslational modification]
755178001145	intermolecular recognition site; other site
755178001146	dimerization interface [polypeptide binding]; other site
755178001147	lipoyl synthase; Provisional; Region: PRK12928
755178001148	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
755178001149	FeS/SAM binding site; other site
755178001150	nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK07428
755178001151	Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572
755178001152	dimerization interface [polypeptide binding]; other site
755178001153	active site
755178001154	Domain of unknown function (DUF4258); Region: DUF4258; pfam14076
755178001155	Protein of unknown function (DUF2283); Region: DUF2283; pfam10049
755178001156	succinyldiaminopimelate transaminase; Validated; Region: PRK07366
755178001157	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
755178001158	pyridoxal 5'-phosphate binding site [chemical binding]; other site
755178001159	homodimer interface [polypeptide binding]; other site
755178001160	catalytic residue [active]
755178001161	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
755178001162	catalytic residues [active]
755178001163	DNA sulfur modification protein DndD; Region: DNA_S_dndD; TIGR03185
755178001164	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
755178001165	Walker A/P-loop; other site
755178001166	ATP binding site [chemical binding]; other site
755178001167	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
755178001168	Q-loop/lid; other site
755178001169	ABC transporter signature motif; other site
755178001170	Walker B; other site
755178001171	D-loop; other site
755178001172	H-loop/switch region; other site
755178001173	hydroxyacylglutathione hydrolase; Region: GSH_gloB; TIGR03413
755178001174	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
755178001175	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
755178001176	metal binding site [ion binding]; metal-binding site
755178001177	active site
755178001178	I-site; other site
755178001179	30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596
755178001180	elongation factor Tu; Region: tufA; CHL00071
755178001181	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
755178001182	G1 box; other site
755178001183	GEF interaction site [polypeptide binding]; other site
755178001184	GTP/Mg2+ binding site [chemical binding]; other site
755178001185	Switch I region; other site
755178001186	G2 box; other site
755178001187	G3 box; other site
755178001188	Switch II region; other site
755178001189	G4 box; other site
755178001190	G5 box; other site
755178001191	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
755178001192	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
755178001193	Antibiotic Binding Site [chemical binding]; other site
755178001194	elongation factor G; Reviewed; Region: PRK00007
755178001195	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
755178001196	G1 box; other site
755178001197	putative GEF interaction site [polypeptide binding]; other site
755178001198	GTP/Mg2+ binding site [chemical binding]; other site
755178001199	Switch I region; other site
755178001200	G2 box; other site
755178001201	G3 box; other site
755178001202	Switch II region; other site
755178001203	G4 box; other site
755178001204	G5 box; other site
755178001205	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
755178001206	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
755178001207	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
755178001208	30S ribosomal protein S7; Validated; Region: PRK05302
755178001209	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
755178001210	S17 interaction site [polypeptide binding]; other site
755178001211	S8 interaction site; other site
755178001212	16S rRNA interaction site [nucleotide binding]; other site
755178001213	streptomycin interaction site [chemical binding]; other site
755178001214	23S rRNA interaction site [nucleotide binding]; other site
755178001215	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
755178001216	Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788
755178001217	glucosylglycerol-phosphate synthase; Region: gluc_glyc_Psyn; TIGR02398
755178001218	active site
755178001219	homotetramer interface [polypeptide binding]; other site
755178001220	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
755178001221	putative active site [active]
755178001222	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
755178001223	putative active site [active]
755178001224	glucosylglycerol 3-phosphatase; Region: salt_tol_Pase; TIGR02399
755178001225	Glucosylglycerol-phosphate phosphatase (Salt_tol_Pase); Region: Salt_tol_Pase; pfam09506
755178001226	Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316
755178001227	Cupin domain; Region: Cupin_2; cl17218
755178001228	GTP-binding protein LepA; Provisional; Region: PRK05433
755178001229	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
755178001230	G1 box; other site
755178001231	putative GEF interaction site [polypeptide binding]; other site
755178001232	GTP/Mg2+ binding site [chemical binding]; other site
755178001233	Switch I region; other site
755178001234	G2 box; other site
755178001235	G3 box; other site
755178001236	Switch II region; other site
755178001237	G4 box; other site
755178001238	G5 box; other site
755178001239	lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699
755178001240	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
755178001241	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
755178001242	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
755178001243	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
755178001244	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
755178001245	dimer interface [polypeptide binding]; other site
755178001246	phosphorylation site [posttranslational modification]
755178001247	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
755178001248	ATP binding site [chemical binding]; other site
755178001249	Mg2+ binding site [ion binding]; other site
755178001250	G-X-G motif; other site
755178001251	Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912
755178001252	Dynamin family; Region: Dynamin_N; pfam00350
755178001253	G1 box; other site
755178001254	GTP/Mg2+ binding site [chemical binding]; other site
755178001255	G2 box; other site
755178001256	Switch I region; other site
755178001257	G3 box; other site
755178001258	Switch II region; other site
755178001259	G4 box; other site
755178001260	G5 box; other site
755178001261	Domain of unknown function (DUF4145); Region: DUF4145; pfam13643
755178001262	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
755178001263	Dynamin family; Region: Dynamin_N; pfam00350
755178001264	G1 box; other site
755178001265	GTP/Mg2+ binding site [chemical binding]; other site
755178001266	G2 box; other site
755178001267	Switch I region; other site
755178001268	Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912
755178001269	G3 box; other site
755178001270	Switch II region; other site
755178001271	GTP/Mg2+ binding site [chemical binding]; other site
755178001272	G4 box; other site
755178001273	G5 box; other site
755178001274	EVE domain; Region: EVE; cl00728
755178001275	Uncharacterized paraquat-inducible protein B [Function unknown]; Region: COG3007
755178001276	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
755178001277	active site
755178001278	NTP binding site [chemical binding]; other site
755178001279	metal binding triad [ion binding]; metal-binding site
755178001280	antibiotic binding site [chemical binding]; other site
755178001281	DNA polymerase III subunit alpha; Reviewed; Region: PRK09532
755178001282	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113
755178001283	active site
755178001284	PHP Thumb interface [polypeptide binding]; other site
755178001285	metal binding site [ion binding]; metal-binding site
755178001286	Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081
755178001287	protein-splicing catalytic site; other site
755178001288	thioester formation/cholesterol transfer; other site
755178001289	This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300
755178001290	homodimer interface [polypeptide binding]; other site
755178001291	glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093
755178001292	active site pocket [active]
755178001293	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
755178001294	putative active site [active]
755178001295	cellulose synthase catalytic subunit (UDP-forming); Region: CelA; TIGR03030
755178001296	CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421
755178001297	DXD motif; other site
755178001298	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438
755178001299	PHP domain; Region: PHP; pfam02811
755178001300	active site
755178001301	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
755178001302	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
755178001303	phosphopeptide binding site; other site
755178001304	PAS domain; Region: PAS; smart00091
755178001305	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
755178001306	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
755178001307	metal binding site [ion binding]; metal-binding site
755178001308	active site
755178001309	I-site; other site
755178001310	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
755178001311	Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390
755178001312	alpha-gamma subunit interface [polypeptide binding]; other site
755178001313	beta-gamma subunit interface [polypeptide binding]; other site
755178001314	urease accessory protein UreE; Provisional; Region: ureE; PRK13261
755178001315	UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571
755178001316	dimer interface [polypeptide binding]; other site
755178001317	catalytic residues [active]
755178001318	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
755178001319	dimer interface [polypeptide binding]; other site
755178001320	conserved gate region; other site
755178001321	putative PBP binding loops; other site
755178001322	ABC-ATPase subunit interface; other site
755178001323	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
755178001324	FOG: CBS domain [General function prediction only]; Region: COG0517
755178001325	FOG: CBS domain [General function prediction only]; Region: COG0517
755178001326	FOG: CBS domain [General function prediction only]; Region: COG0517
755178001327	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with a PAS domain, a GGDEF (DiGuanylate-Cyclase (DGC) domain, and a DUF1 domain downstream. PAS domains have been found to bind ligands, and to act...; Region: CBS_pair_PAS_GGDEF_DUF1_assoc; cd04611
755178001328	GAF domain; Region: GAF_2; pfam13185
755178001329	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
755178001330	PAS domain S-box; Region: sensory_box; TIGR00229
755178001331	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
755178001332	putative active site [active]
755178001333	heme pocket [chemical binding]; other site
755178001334	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
755178001335	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
755178001336	putative active site [active]
755178001337	heme pocket [chemical binding]; other site
755178001338	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
755178001339	putative active site [active]
755178001340	heme pocket [chemical binding]; other site
755178001341	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
755178001342	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
755178001343	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
755178001344	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
755178001345	dimer interface [polypeptide binding]; other site
755178001346	phosphorylation site [posttranslational modification]
755178001347	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
755178001348	ATP binding site [chemical binding]; other site
755178001349	Mg2+ binding site [ion binding]; other site
755178001350	G-X-G motif; other site
755178001351	Response regulator receiver domain; Region: Response_reg; pfam00072
755178001352	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
755178001353	active site
755178001354	phosphorylation site [posttranslational modification]
755178001355	intermolecular recognition site; other site
755178001356	dimerization interface [polypeptide binding]; other site
755178001357	Uncharacterized protein related to deoxyribodipyrimidine photolyase [General function prediction only]; Region: COG3046
755178001358	Deoxyribodipyrimidine photo-lyase-related protein; Region: DPRP; pfam04244
755178001359	pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493
755178001360	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
755178001361	FeS/SAM binding site; other site
755178001362	inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02649
755178001363	ATP-NAD kinase; Region: NAD_kinase; pfam01513
755178001364	phosphate transporter ATP-binding protein; Provisional; Region: PRK14243
755178001365	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
755178001366	Walker A/P-loop; other site
755178001367	ATP binding site [chemical binding]; other site
755178001368	Q-loop/lid; other site
755178001369	ABC transporter signature motif; other site
755178001370	Walker B; other site
755178001371	D-loop; other site
755178001372	H-loop/switch region; other site
755178001373	ATP cone domain; Region: ATP-cone; pfam03477
755178001374	ribonucleoside-diphosphate reductase, alpha subunit; Region: NrdE_NrdA; TIGR02506
755178001375	Class I ribonucleotide reductase; Region: RNR_I; cd01679
755178001376	active site
755178001377	dimer interface [polypeptide binding]; other site
755178001378	catalytic residues [active]
755178001379	effector binding site; other site
755178001380	R2 peptide binding site; other site
755178001381	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
755178001382	Ligand Binding Site [chemical binding]; other site
755178001383	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
755178001384	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
755178001385	Ligand binding site; other site
755178001386	Putative Catalytic site; other site
755178001387	DXD motif; other site
755178001388	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
755178001389	GAF domain; Region: GAF; pfam01590
755178001390	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
755178001391	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
755178001392	dimer interface [polypeptide binding]; other site
755178001393	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
755178001394	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
755178001395	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
755178001396	Walker A/P-loop; other site
755178001397	ATP binding site [chemical binding]; other site
755178001398	Q-loop/lid; other site
755178001399	ABC transporter signature motif; other site
755178001400	Walker B; other site
755178001401	D-loop; other site
755178001402	H-loop/switch region; other site
755178001403	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
755178001404	active site
755178001405	tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291
755178001406	GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396
755178001407	trmE is a tRNA modification GTPase; Region: trmE; cd04164
755178001408	G1 box; other site
755178001409	GTP/Mg2+ binding site [chemical binding]; other site
755178001410	Switch I region; other site
755178001411	G2 box; other site
755178001412	Switch II region; other site
755178001413	G3 box; other site
755178001414	G4 box; other site
755178001415	G5 box; other site
755178001416	Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631
755178001417	acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198
755178001418	acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724
755178001419	1,4-dihydroxy-2-naphthoate octaprenyltransferase; Provisional; Region: PRK07419
755178001420	UbiA prenyltransferase family; Region: UbiA; pfam01040
755178001421	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
755178001422	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
755178001423	chorismate binding enzyme; Region: Chorismate_bind; cl10555
755178001424	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
755178001425	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
755178001426	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
755178001427	Protein of unknown function (DUF3082); Region: DUF3082; pfam11282
755178001428	Mg-protoporyphyrin IX chelatase; Region: chlI; CHL00081
755178001429	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
755178001430	Walker A/P-loop; other site
755178001431	ATP binding site [chemical binding]; other site
755178001432	photosystem I P700 chlorophyll a apoprotein A2; Provisional; Region: psaB; PRK13199
755178001433	photosystem I P700 chlorophyll a apoprotein A1; Region: psaA; CHL00056
755178001434	LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025
755178001435	dimer interface [polypeptide binding]; other site
755178001436	catalytic triad [active]
755178001437	N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436
755178001438	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
755178001439	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
755178001440	active site
755178001441	SAM binding site [chemical binding]; other site
755178001442	homodimer interface [polypeptide binding]; other site
755178001443	Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587
755178001444	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
755178001445	active site
755178001446	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
755178001447	Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167
755178001448	putative substrate binding site [chemical binding]; other site
755178001449	putative ATP binding site [chemical binding]; other site
755178001450	Response regulator receiver domain; Region: Response_reg; pfam00072
755178001451	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
755178001452	active site
755178001453	phosphorylation site [posttranslational modification]
755178001454	intermolecular recognition site; other site
755178001455	dimerization interface [polypeptide binding]; other site
755178001456	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
755178001457	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
755178001458	metal binding site [ion binding]; metal-binding site
755178001459	active site
755178001460	I-site; other site
755178001461	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
755178001462	phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108
755178001463	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
755178001464	Mg++ binding site [ion binding]; other site
755178001465	putative catalytic motif [active]
755178001466	putative substrate binding site [chemical binding]; other site
755178001467	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
755178001468	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
755178001469	phosphopeptide binding site; other site
755178001470	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
755178001471	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
755178001472	putative active site [active]
755178001473	heme pocket [chemical binding]; other site
755178001474	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
755178001475	metal binding site [ion binding]; metal-binding site
755178001476	active site
755178001477	I-site; other site
755178001478	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
755178001479	Uncharacterized BCR, COG1649; Region: DUF187; pfam02638
755178001480	Protein of unknown function (DUF3539); Region: DUF3539; pfam12058
755178001481	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
755178001482	IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639
755178001483	active site
755178001484	dimerization interface [polypeptide binding]; other site
755178001485	Coenzyme F420-reducing hydrogenase, beta subunit [Energy production and conversion]; Region: FrhB; COG1035
755178001486	Coenzyme F420 hydrogenase/dehydrogenase, beta subunit N-term; Region: FrhB_FdhB_N; pfam04422
755178001487	Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus; Region: FrhB_FdhB_C; pfam04432
755178001488	ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839
755178001489	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
755178001490	Walker A/P-loop; other site
755178001491	ATP binding site [chemical binding]; other site
755178001492	Q-loop/lid; other site
755178001493	ABC transporter signature motif; other site
755178001494	Walker B; other site
755178001495	D-loop; other site
755178001496	H-loop/switch region; other site
755178001497	TOBE domain; Region: TOBE_2; pfam08402
755178001498	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
755178001499	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
755178001500	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
755178001501	dimer interface [polypeptide binding]; other site
755178001502	conserved gate region; other site
755178001503	putative PBP binding loops; other site
755178001504	ABC-ATPase subunit interface; other site
755178001505	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
755178001506	dimer interface [polypeptide binding]; other site
755178001507	conserved gate region; other site
755178001508	putative PBP binding loops; other site
755178001509	ABC-ATPase subunit interface; other site
755178001510	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
755178001511	active site
755178001512	catalytic triad [active]
755178001513	oxyanion hole [active]
755178001514	Domain of unknown function (DUF427); Region: DUF427; pfam04248
755178001515	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
755178001516	Protein of unknown function DUF58; Region: DUF58; pfam01882
755178001517	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
755178001518	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
755178001519	Walker A/P-loop; other site
755178001520	ATP binding site [chemical binding]; other site
755178001521	Q-loop/lid; other site
755178001522	ABC transporter signature motif; other site
755178001523	Walker B; other site
755178001524	D-loop; other site
755178001525	H-loop/switch region; other site
755178001526	GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate.  The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria.  In...; Region: GTP_cyclohydro1; cd00642
755178001527	homodecamer interface [polypeptide binding]; other site
755178001528	GTP cyclohydrolase I; Provisional; Region: PLN03044
755178001529	active site
755178001530	putative catalytic site residues [active]
755178001531	zinc binding site [ion binding]; other site
755178001532	GTP-CH-I/GFRP interaction surface; other site
755178001533	short chain dehydrogenase; Provisional; Region: PRK07454
755178001534	classical (c) SDRs; Region: SDR_c; cd05233
755178001535	NAD(P) binding site [chemical binding]; other site
755178001536	active site
755178001537	Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dam; COG0338
755178001538	glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750
755178001539	Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713
755178001540	active site
755178001541	dimer interface [polypeptide binding]; other site
755178001542	Glutamate synthase central domain; Region: Glu_syn_central; pfam04898
755178001543	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
755178001544	active site
755178001545	FMN binding site [chemical binding]; other site
755178001546	substrate binding site [chemical binding]; other site
755178001547	3Fe-4S cluster binding site [ion binding]; other site
755178001548	gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982
755178001549	domain interface; other site
755178001550	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
755178001551	DNA-binding site [nucleotide binding]; DNA binding site
755178001552	RNA-binding motif; other site
755178001553	YcfA-like protein; Region: YcfA; pfam07927
755178001554	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
755178001555	RNA polymerase sigma factor, cyanobacterial RpoD-like family; Region: Sig70-cyanoRpoD; TIGR02997
755178001556	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
755178001557	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
755178001558	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
755178001559	DNA binding residues [nucleotide binding]
755178001560	Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407
755178001561	gamma-beta subunit interface [polypeptide binding]; other site
755178001562	alpha-beta subunit interface [polypeptide binding]; other site
755178001563	ribosomal protein L31; Validated; Region: rpl31; CHL00136
755178001564	ribosomal protein S9; Region: rps9; CHL00079
755178001565	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
755178001566	23S rRNA interface [nucleotide binding]; other site
755178001567	L3 interface [polypeptide binding]; other site
755178001568	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
755178001569	Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA; Region: PseudoU_synth_EcTruA; cd02570
755178001570	dimerization interface 3.5A [polypeptide binding]; other site
755178001571	active site
755178001572	50S ribosomal protein L17; Validated; Region: rplQ; PRK05591
755178001573	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
755178001574	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
755178001575	alphaNTD homodimer interface [polypeptide binding]; other site
755178001576	alphaNTD - beta interaction site [polypeptide binding]; other site
755178001577	alphaNTD - beta' interaction site [polypeptide binding]; other site
755178001578	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
755178001579	30S ribosomal protein S11; Validated; Region: PRK05309
755178001580	30S ribosomal protein S13; Validated; Region: rpsM; PRK05179
755178001581	30S ribosomal protein S13; Region: bact_S13; TIGR03631
755178001582	50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465
755178001583	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
755178001584	rRNA binding site [nucleotide binding]; other site
755178001585	predicted 30S ribosome binding site; other site
755178001586	adenylate kinase; Reviewed; Region: adk; PRK00279
755178001587	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
755178001588	AMP-binding site [chemical binding]; other site
755178001589	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
755178001590	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
755178001591	SecY translocase; Region: SecY; pfam00344
755178001592	50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592
755178001593	30S ribosomal protein S5; Validated; Region: rpsE; PRK00550
755178001594	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
755178001595	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
755178001596	23S rRNA interface [nucleotide binding]; other site
755178001597	L21e interface [polypeptide binding]; other site
755178001598	5S rRNA interface [nucleotide binding]; other site
755178001599	L27 interface [polypeptide binding]; other site
755178001600	L5 interface [polypeptide binding]; other site
755178001601	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
755178001602	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
755178001603	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
755178001604	30S ribosomal protein S8; Validated; Region: rpsH; PRK00136
755178001605	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
755178001606	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
755178001607	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
755178001608	50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004
755178001609	KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089
755178001610	RNA binding site [nucleotide binding]; other site
755178001611	ribosomal protein L14; Region: rpl14; CHL00057
755178001612	30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610
755178001613	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427
755178001614	23S rRNA interface [nucleotide binding]; other site
755178001615	putative translocon interaction site; other site
755178001616	signal recognition particle (SRP54) interaction site; other site
755178001617	L23 interface [polypeptide binding]; other site
755178001618	trigger factor interaction site; other site
755178001619	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
755178001620	23S rRNA interface [nucleotide binding]; other site
755178001621	5S rRNA interface [nucleotide binding]; other site
755178001622	putative antibiotic binding site [chemical binding]; other site
755178001623	L25 interface [polypeptide binding]; other site
755178001624	L27 interface [polypeptide binding]; other site
755178001625	30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310
755178001626	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
755178001627	G-X-X-G motif; other site
755178001628	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
755178001629	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
755178001630	putative translocon binding site; other site
755178001631	protein-rRNA interface [nucleotide binding]; other site
755178001632	30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357
755178001633	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
755178001634	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
755178001635	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
755178001636	50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738
755178001637	50S ribosomal protein L4; Provisional; Region: rplD; PRK05319
755178001638	50S ribosomal protein L3; Validated; Region: rplC; PRK00001
755178001639	Putative heavy-metal-binding; Region: YbjQ_1; cl00426
755178001640	Uncharacterized conserved protein [Function unknown]; Region: COG2135
755178001641	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
755178001642	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
755178001643	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
755178001644	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
755178001645	Sulfate transporter family; Region: Sulfate_transp; pfam00916
755178001646	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
755178001647	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750
755178001648	catalytic triad [active]
755178001649	PBP superfamily domain; Region: PBP_like_2; cl17296
755178001650	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
755178001651	EamA-like transporter family; Region: EamA; pfam00892
755178001652	EamA-like transporter family; Region: EamA; pfam00892
755178001653	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
755178001654	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
755178001655	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
755178001656	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
755178001657	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
755178001658	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
755178001659	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
755178001660	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
755178001661	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
755178001662	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
755178001663	This is a family of GT1 glycosyltransferases found specifically in certain bacteria. amsK in Erwinia amylovora, has been reported to be involved in the biosynthesis of amylovoran, a exopolysaccharide acting as a virulence factor; Region: GT1_amsK_like; cd03799
755178001664	putative ADP-binding pocket [chemical binding]; other site
755178001665	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
755178001666	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
755178001667	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
755178001668	phosphopeptide binding site; other site
755178001669	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
755178001670	AcrB/AcrD/AcrF family; Region: ACR_tran; pfam00873
755178001671	Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226
755178001672	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
755178001673	S-adenosylmethionine binding site [chemical binding]; other site
755178001674	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
755178001675	UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs; Region: UGD_SDR_e; cd05230
755178001676	NAD binding site [chemical binding]; other site
755178001677	putative substrate binding site 2 [chemical binding]; other site
755178001678	putative substrate binding site 1 [chemical binding]; other site
755178001679	active site
755178001680	Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004
755178001681	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
755178001682	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
755178001683	UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720
755178001684	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
755178001685	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
755178001686	catalytic loop [active]
755178001687	iron binding site [ion binding]; other site
755178001688	Domain of unknown function (DUF4335); Region: DUF4335; pfam14233
755178001689	Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028
755178001690	classical (c) SDRs; Region: SDR_c; cd05233
755178001691	NAD(P) binding site [chemical binding]; other site
755178001692	active site
755178001693	urease subunit alpha; Reviewed; Region: ureC; PRK13207
755178001694	Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375
755178001695	subunit interactions [polypeptide binding]; other site
755178001696	active site
755178001697	flap region; other site
755178001698	ABC exporter ATP-binding subunit, DevA family; Region: heterocyst_DevA; TIGR02982
755178001699	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
755178001700	Walker A/P-loop; other site
755178001701	ATP binding site [chemical binding]; other site
755178001702	Q-loop/lid; other site
755178001703	ABC transporter signature motif; other site
755178001704	Walker B; other site
755178001705	D-loop; other site
755178001706	H-loop/switch region; other site
755178001707	dihydroorotase; Provisional; Region: PRK07369
755178001708	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
755178001709	Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317
755178001710	active site
755178001711	Sm and related proteins; Region: Sm_like; cl00259
755178001712	heptamer interface [polypeptide binding]; other site
755178001713	Sm1 motif; other site
755178001714	hexamer interface [polypeptide binding]; other site
755178001715	RNA binding site [nucleotide binding]; other site
755178001716	Sm2 motif; other site
755178001717	diaminopimelate epimerase; Provisional; Region: dapF; PRK00450
755178001718	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
755178001719	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
755178001720	Domain of unknown function (DUF1830); Region: DUF1830; pfam08865
755178001721	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
755178001722	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
755178001723	active site
755178001724	phosphorylation site [posttranslational modification]
755178001725	intermolecular recognition site; other site
755178001726	dimerization interface [polypeptide binding]; other site
755178001727	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
755178001728	DNA binding site [nucleotide binding]
755178001729	ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040
755178001730	ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686
755178001731	ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265
755178001732	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
755178001733	ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254
755178001734	Walker A/P-loop; other site
755178001735	ATP binding site [chemical binding]; other site
755178001736	Q-loop/lid; other site
755178001737	ABC transporter signature motif; other site
755178001738	Walker B; other site
755178001739	D-loop; other site
755178001740	H-loop/switch region; other site
755178001741	2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800
755178001742	KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452
755178001743	active site
755178001744	intersubunit interface [polypeptide binding]; other site
755178001745	catalytic residue [active]
755178001746	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
755178001747	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
755178001748	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
755178001749	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
755178001750	Photosystem II reaction centre N protein (psbN); Region: PsbN; pfam02468
755178001751	photosystem II reaction center protein H; Provisional; Region: psbH; PRK02624
755178001752	mttA/Hcf106 family; Region: MttA_Hcf106; cl00788
755178001753	Predicted kinase related to galactokinase and mevalonate kinase [General function prediction only]; Region: COG2605
755178001754	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
755178001755	16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050
755178001756	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
755178001757	S-adenosylmethionine binding site [chemical binding]; other site
755178001758	shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258
755178001759	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
755178001760	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
755178001761	shikimate binding site; other site
755178001762	NAD(P) binding site [chemical binding]; other site
755178001763	calcium/proton exchanger (cax); Region: cax; TIGR00378
755178001764	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
755178001765	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
755178001766	UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769
755178001767	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
755178001768	Domain of unknown function (DUF1727); Region: DUF1727; pfam08353
755178001769	CRISPR-associated (Cas) DxTHG family; Region: Cas_DxTHG; pfam09455
755178001770	CRISPR/Cas system-associated protein Csx1; Region: Csx1_III-U; cd09732
755178001771	CRISPR/Cas system-associated protein Csx1; Region: Csx1_III-U; cl17439
755178001772	CRISPR/Cas system-associated protein Csm6; Region: Csm6_III-A; cl01634
755178001773	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
755178001774	putative active site [active]
755178001775	CRISPR-associated protein; Region: TIGR03986
755178001776	CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cd09726
755178001777	CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cl17214
755178001778	CRISPR-associated protein, TIGR03984 family; Region: TIGR03984
755178001779	CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cd09726
755178001780	CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cd09726
755178001781	CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cd09726
755178001782	CRISPR/Cas system-associated RAMP superfamily protein Csx10; Region: Csx10; cl17558
755178001783	Predicted CRISPR-associated polymerase [Defense mechanisms]; Region: COG1353
755178001784	Glycogen debranching enzyme [Carbohydrate transport and metabolism]; Region: GDB1; COG3408
755178001785	Amylo-alpha-1,6-glucosidase; Region: GDE_C; pfam06202
755178001786	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
755178001787	This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802
755178001788	putative ADP-binding pocket [chemical binding]; other site
755178001789	glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389
755178001790	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
755178001791	Predicted integral membrane protein [Function unknown]; Region: COG5660
755178001792	RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652
755178001793	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
755178001794	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
755178001795	DNA binding residues [nucleotide binding]
755178001796	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
755178001797	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
755178001798	phosphopeptide binding site; other site
755178001799	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
755178001800	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
755178001801	metal binding site [ion binding]; metal-binding site
755178001802	active site
755178001803	I-site; other site
755178001804	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
755178001805	TIGR00701 family protein; Region: TIGR00701
755178001806	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
755178001807	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
755178001808	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
755178001809	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
755178001810	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
755178001811	active site
755178001812	catalytic residues [active]
755178001813	DNA binding site [nucleotide binding]
755178001814	Int/Topo IB signature motif; other site
755178001815	Virulence-associated protein E; Region: VirE; pfam05272
755178001816	DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481
755178001817	N-acylamino acid racemase (NAAAR), an octameric enzyme that catalyzes the racemization of N-acylamino acids. NAAARs act on a broad range of N-acylamino acids rather than amino acids. Enantiopure amino acids are of industrial interest as chiral building...; Region: NAAAR; cd03317
755178001818	o-succinylbenzoate synthase; Region: menC_lowGC/arch; TIGR01928
755178001819	active site
755178001820	octamer interface [polypeptide binding]; other site
755178001821	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
755178001822	cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077
755178001823	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
755178001824	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130
755178001825	catalytic triad [active]
755178001826	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
755178001827	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
755178001828	active site
755178001829	phosphorylation site [posttranslational modification]
755178001830	intermolecular recognition site; other site
755178001831	dimerization interface [polypeptide binding]; other site
755178001832	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
755178001833	DNA binding site [nucleotide binding]
755178001834	glyceraldehyde-3-phosphate dehydrogenase; Validated; Region: PRK08955
755178001835	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
755178001836	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
755178001837	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
755178001838	putative substrate translocation pore; other site
755178001839	Major Facilitator Superfamily; Region: MFS_1; pfam07690
755178001840	ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109
755178001841	ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561
755178001842	homodimer interface [polypeptide binding]; other site
755178001843	Walker A motif; other site
755178001844	ATP binding site [chemical binding]; other site
755178001845	hydroxycobalamin binding site [chemical binding]; other site
755178001846	Walker B motif; other site
755178001847	Recombination protein O N terminal; Region: RecO_N; pfam11967
755178001848	DNA repair protein RecO; Reviewed; Region: recO; PRK00085
755178001849	Recombination protein O C terminal; Region: RecO_C; pfam02565
755178001850	Predicted transmembrane sensor domain [Signal transduction mechanisms]; Region: COG4252
755178001851	CHASE2 domain; Region: CHASE2; pfam05226
755178001852	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
755178001853	Catalytic domain of Protein Kinases; Region: PKc; cd00180
755178001854	active site
755178001855	ATP binding site [chemical binding]; other site
755178001856	substrate binding site [chemical binding]; other site
755178001857	activation loop (A-loop); other site
755178001858	Family description; Region: VCBS; pfam13517
755178001859	Family description; Region: VCBS; pfam13517
755178001860	Family description; Region: VCBS; pfam13517
755178001861	Calx-beta domain; Region: Calx-beta; cl02522
755178001862	Calx-beta domain; Region: Calx-beta; cl02522
755178001863	Tetratricopeptide repeat; Region: TPR_12; pfam13424
755178001864	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
755178001865	binding surface
755178001866	TPR motif; other site
755178001867	TPR repeat; Region: TPR_11; pfam13414
755178001868	thiamine monophosphate kinase; Provisional; Region: PRK05731
755178001869	ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194
755178001870	ATP binding site [chemical binding]; other site
755178001871	dimerization interface [polypeptide binding]; other site
755178001872	Response regulator receiver domain; Region: Response_reg; pfam00072
755178001873	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
755178001874	active site
755178001875	phosphorylation site [posttranslational modification]
755178001876	intermolecular recognition site; other site
755178001877	dimerization interface [polypeptide binding]; other site
755178001878	tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335
755178001879	Glucose inhibited division protein A; Region: GIDA; pfam01134
755178001880	phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213
755178001881	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203
755178001882	dimerization interface [polypeptide binding]; other site
755178001883	ATP binding site [chemical binding]; other site
755178001884	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204
755178001885	dimerization interface [polypeptide binding]; other site
755178001886	ATP binding site [chemical binding]; other site
755178001887	methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444
755178001888	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
755178001889	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
755178001890	coproporphyrinogen III oxidase; Provisional; Region: PRK07379
755178001891	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377
755178001892	FeS/SAM binding site; other site
755178001893	HemN C-terminal domain; Region: HemN_C; pfam06969
755178001894	Predicted flavoprotein [General function prediction only]; Region: COG0431
755178001895	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
755178001896	NADH dehydrogenase subunit 1; Region: ndhA; CHL00032
755178001897	Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650
755178001898	Uncharacterized conserved protein [Function unknown]; Region: COG2928
755178001899	inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02645
755178001900	ATP-NAD kinase; Region: NAD_kinase; pfam01513
755178001901	DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420
755178001902	Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840
755178001903	active site
755178001904	metal binding site [ion binding]; metal-binding site
755178001905	DNA binding site [nucleotide binding]
755178001906	ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864
755178001907	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
755178001908	Walker A/P-loop; other site
755178001909	ATP binding site [chemical binding]; other site
755178001910	Q-loop/lid; other site
755178001911	ABC transporter signature motif; other site
755178001912	Walker B; other site
755178001913	D-loop; other site
755178001914	H-loop/switch region; other site
755178001915	Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079
755178001916	gamma-glutamyl phosphate reductase; Region: proA; TIGR00407
755178001917	putative catalytic cysteine [active]
755178001918	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
755178001919	6-phosphogluconate dehydrogenase; Validated; Region: PRK09287
755178001920	6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393
755178001921	oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701
755178001922	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
755178001923	molybdopterin cofactor binding site; other site
755178001924	Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929
755178001925	molybdopterin cofactor binding site; other site
755178001926	Protein of unknown function (DUF3122); Region: DUF3122; pfam11320
755178001927	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
755178001928	binding surface
755178001929	TPR motif; other site
755178001930	TPR repeat; Region: TPR_11; pfam13414
755178001931	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
755178001932	binding surface
755178001933	TPR motif; other site
755178001934	Tetratricopeptide repeat; Region: TPR_16; pfam13432
755178001935	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
755178001936	TPR motif; other site
755178001937	binding surface
755178001938	c-type cytochrome biogenensis protein; Validated; Region: ccs1; CHL00177
755178001939	ResB-like family; Region: ResB; pfam05140
755178001940	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
755178001941	active site residue [active]
755178001942	Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like subfamily; subgroup includes Pseudomonas aeruginosa AotO; Region: M14_PaAOTO_like; cd06250
755178001943	Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952
755178001944	active site
755178001945	Zn binding site [ion binding]; other site
755178001946	GTPase Era; Reviewed; Region: era; PRK00089
755178001947	E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163
755178001948	G1 box; other site
755178001949	GTP/Mg2+ binding site [chemical binding]; other site
755178001950	Switch I region; other site
755178001951	G2 box; other site
755178001952	Switch II region; other site
755178001953	G3 box; other site
755178001954	G4 box; other site
755178001955	G5 box; other site
755178001956	KH domain; Region: KH_2; pfam07650
755178001957	Uncharacterized conserved protein [Function unknown]; Region: COG0397
755178001958	hypothetical protein; Validated; Region: PRK00029
755178001959	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
755178001960	Ribulose bisphosphate carboxylase/oxygenase (Rubisco), small subunit. Rubisco is a bifunctional enzyme catalyzes the initial steps of two opposing metabolic pathways: photosynthetic carbon fixation and the competing process of photorespiration. Rubisco...; Region: RuBisCO_small; cd03527
755178001961	multimerization interface [polypeptide binding]; other site
755178001962	RbcX protein; Region: RcbX; pfam02341
755178001963	ribulose-1,5-bisphosphate carboxylase/oxygenase large subunit; Region: rbcL; CHL00040
755178001964	Ribulose bisphosphate carboxylase large chain, Form I; Region: RuBisCO_large_I; cd08212
755178001965	homodimer interface [polypeptide binding]; other site
755178001966	active site
755178001967	heterodimer interface [polypeptide binding]; other site
755178001968	catalytic residue [active]
755178001969	metal binding site [ion binding]; metal-binding site
755178001970	ribosome-binding factor A; Validated; Region: rbfA; PRK00521
755178001971	Protein of unknown function (DUF751); Region: DUF751; pfam05421
755178001972	Domain of unknown function (DUF4388); Region: DUF4388; pfam14332
755178001973	Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443
755178001974	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cl03075
755178001975	dimer interface [polypeptide binding]; other site
755178001976	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
755178001977	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
755178001978	dimerization interface [polypeptide binding]; other site
755178001979	putative DNA binding site [nucleotide binding]; other site
755178001980	putative Zn2+ binding site [ion binding]; other site
755178001981	Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663
755178001982	Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645
755178001983	trimer interface [polypeptide binding]; other site
755178001984	putative metal binding site [ion binding]; other site
755178001985	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
755178001986	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
755178001987	Coenzyme A binding pocket [chemical binding]; other site
755178001988	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
755178001989	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
755178001990	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
755178001991	Protein of unknown function (DUF2442); Region: DUF2442; pfam10387
755178001992	D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966
755178001993	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
755178001994	D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478
755178001995	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
755178001996	aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012
755178001997	EamA-like transporter family; Region: EamA; cl17759
755178001998	hopanoid biosynthesis associated radical SAM protein HpnJ; Region: HpnJ; TIGR03471
755178001999	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
755178002000	B12 binding site [chemical binding]; other site
755178002001	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
755178002002	FeS/SAM binding site; other site
755178002003	Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501
755178002004	Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985
755178002005	RibD C-terminal domain; Region: RibD_C; cl17279
755178002006	DNA polymerase I; Provisional; Region: PRK05755
755178002007	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
755178002008	active site
755178002009	metal binding site 1 [ion binding]; metal-binding site
755178002010	putative 5' ssDNA interaction site; other site
755178002011	metal binding site 3; metal-binding site
755178002012	metal binding site 2 [ion binding]; metal-binding site
755178002013	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
755178002014	putative DNA binding site [nucleotide binding]; other site
755178002015	putative metal binding site [ion binding]; other site
755178002016	DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139
755178002017	active site
755178002018	catalytic site [active]
755178002019	substrate binding site [chemical binding]; other site
755178002020	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
755178002021	active site
755178002022	DNA binding site [nucleotide binding]
755178002023	catalytic site [active]
755178002024	Transcriptional regulator [Transcription]; Region: LytR; COG1316
755178002025	LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399
755178002026	3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175
755178002027	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
755178002028	Active Sites [active]
755178002029	Predicted permease [General function prediction only]; Region: COG3329
755178002030	Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831
755178002031	POTRA domain, ShlB-type; Region: POTRA_2; pfam08479
755178002032	Surface antigen; Region: Bac_surface_Ag; pfam01103
755178002033	Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210
755178002034	haemagglutination activity domain; Region: Haemagg_act; pfam05860
755178002035	CHAT domain; Region: CHAT; pfam12770
755178002036	Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987
755178002037	Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987
755178002038	Mitochondrial biogenesis AIM24; Region: AIM24; cl00884
755178002039	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395
755178002040	Protein of unknown function (DUF3038); Region: DUF3038; pfam11237
755178002041	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
755178002042	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
755178002043	Ligand binding site; other site
755178002044	Putative Catalytic site; other site
755178002045	DXD motif; other site
755178002046	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
755178002047	active site
755178002048	NTP binding site [chemical binding]; other site
755178002049	metal binding triad [ion binding]; metal-binding site
755178002050	antibiotic binding site [chemical binding]; other site
755178002051	Protein of unknown function (DUF2869); Region: DUF2869; pfam11068
755178002052	Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022
755178002053	Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907
755178002054	acyl-activating enzyme (AAE) consensus motif; other site
755178002055	putative AMP binding site [chemical binding]; other site
755178002056	putative active site [active]
755178002057	putative CoA binding site [chemical binding]; other site
755178002058	CTP synthetase; Validated; Region: pyrG; PRK05380
755178002059	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
755178002060	Catalytic site [active]
755178002061	active site
755178002062	UTP binding site [chemical binding]; other site
755178002063	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
755178002064	active site
755178002065	putative oxyanion hole; other site
755178002066	catalytic triad [active]
755178002067	Rubredoxin [Energy production and conversion]; Region: COG1773
755178002068	Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730
755178002069	iron binding site [ion binding]; other site
755178002070	Ycf48-like protein; Provisional; Region: PRK13684
755178002071	cytochrome b559 subunit alpha; Provisional; Region: psbE; PRK02557
755178002072	Cytochrome b559, alpha (gene psbE) and beta (gene psbF)subunits; Region: Cytochrom_B559; pfam00283
755178002073	Lumenal portion of Cytochrome b559, alpha (gene psbE) subunit; Region: Cytochrom_B559a; pfam00284
755178002074	cytochrome b559 subunit beta; Provisional; Region: psbF; PRK02561
755178002075	photosystem II reaction center L; Provisional; Region: psbL; PRK00753
755178002076	PsbJ; Region: PsbJ; cl09469
755178002077	DALR anticodon binding domain; Region: DALR_1; smart00836
755178002078	Heme-copper oxidase subunit III.  Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cl00211
755178002079	Circularly permuted YlqF-related GTPases; Region: YlqF_related_GTPase; cl17249
755178002080	GTP/Mg2+ binding site [chemical binding]; other site
755178002081	G4 box; other site
755178002082	G5 box; other site
755178002083	Predicted GTPase [General function prediction only]; Region: COG3596
755178002084	YfjP GTPase; Region: YfjP; cd11383
755178002085	G1 box; other site
755178002086	G1 box; other site
755178002087	GTP/Mg2+ binding site [chemical binding]; other site
755178002088	Switch I region; other site
755178002089	Switch I region; other site
755178002090	G2 box; other site
755178002091	G2 box; other site
755178002092	Switch II region; other site
755178002093	G3 box; other site
755178002094	G3 box; other site
755178002095	Switch II region; other site
755178002096	G4 box; other site
755178002097	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
755178002098	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
755178002099	active site
755178002100	phosphorylation site [posttranslational modification]
755178002101	intermolecular recognition site; other site
755178002102	dimerization interface [polypeptide binding]; other site
755178002103	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
755178002104	DNA binding site [nucleotide binding]
755178002105	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
755178002106	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
755178002107	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
755178002108	active site
755178002109	phosphorylation site [posttranslational modification]
755178002110	intermolecular recognition site; other site
755178002111	dimerization interface [polypeptide binding]; other site
755178002112	NifU-like domain; Region: NifU; pfam01106
755178002113	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
755178002114	active site
755178002115	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
755178002116	GAF domain; Region: GAF; pfam01590
755178002117	PAS domain S-box; Region: sensory_box; TIGR00229
755178002118	PAS domain S-box; Region: sensory_box; TIGR00229
755178002119	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
755178002120	putative active site [active]
755178002121	heme pocket [chemical binding]; other site
755178002122	Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits; Region: iSH2_PI3K_IA_R; cl17108
755178002123	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
755178002124	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
755178002125	dimer interface [polypeptide binding]; other site
755178002126	phosphorylation site [posttranslational modification]
755178002127	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
755178002128	ATP binding site [chemical binding]; other site
755178002129	Mg2+ binding site [ion binding]; other site
755178002130	G-X-G motif; other site
755178002131	Response regulator receiver domain; Region: Response_reg; pfam00072
755178002132	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
755178002133	active site
755178002134	phosphorylation site [posttranslational modification]
755178002135	intermolecular recognition site; other site
755178002136	dimerization interface [polypeptide binding]; other site
755178002137	Protein of unknown function (DUF3119); Region: DUF3119; pfam11317
755178002138	Protein of unknown function (DUF3086); Region: DUF3086; pfam11285
755178002139	YciI-like protein; Reviewed; Region: PRK12864
755178002140	Ion channel; Region: Ion_trans_2; pfam07885
755178002141	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
755178002142	TrkA-N domain; Region: TrkA_N; pfam02254
755178002143	TrkA-C domain; Region: TrkA_C; pfam02080
755178002144	Chorismate mutase (AroH) is one of at least five chorismate-utilizing enzymes present in microorganisms that catalyze the rearrangement of chorismate to prephenic acid, the first committed step in the biosynthesis of aromatic amino acids. In prokaryotes; Region: AroH; cd02185
755178002145	homotrimer interaction site [polypeptide binding]; other site
755178002146	active site
755178002147	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
755178002148	signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706
755178002149	tandem repeat interface [polypeptide binding]; other site
755178002150	oligomer interface [polypeptide binding]; other site
755178002151	active site residues [active]
755178002152	Prokaryotic metallothionein; Region: Metallothio_Pro; pfam02069
755178002153	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
755178002154	Ligand Binding Site [chemical binding]; other site
755178002155	This domain is the catalytic domain of ribonuclease II; Region: RNB; smart00955
755178002156	RNB domain; Region: RNB; pfam00773
755178002157	hypothetical protein; Provisional; Region: PRK07394
755178002158	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
755178002159	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
755178002160	Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516
755178002161	Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320
755178002162	putative active site [active]
755178002163	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
755178002164	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
755178002165	catalytic loop [active]
755178002166	iron binding site [ion binding]; other site
755178002167	PIN domain; Region: PIN_3; cl17397
755178002168	R.HinP1I restriction endonuclease; Region: R-HINP1I; pfam11463
755178002169	magnesium chelatase subunit H; Provisional; Region: PLN03241
755178002170	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
755178002171	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
755178002172	Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402
755178002173	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
755178002174	oligomeric interface; other site
755178002175	putative active site [active]
755178002176	homodimer interface [polypeptide binding]; other site
755178002177	probable polyamine oxidase; Region: PLN02268
755178002178	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
755178002179	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
755178002180	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
755178002181	active site
755178002182	phosphorylation site [posttranslational modification]
755178002183	intermolecular recognition site; other site
755178002184	dimerization interface [polypeptide binding]; other site
755178002185	cryptochrome, DASH family; Region: crypto_DASH; TIGR02765
755178002186	DNA photolyase; Region: DNA_photolyase; pfam00875
755178002187	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725
755178002188	active site
755178002189	dimer interface [polypeptide binding]; other site
755178002190	Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: COG2402
755178002191	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
755178002192	active site
755178002193	NTP binding site [chemical binding]; other site
755178002194	metal binding triad [ion binding]; metal-binding site
755178002195	antibiotic binding site [chemical binding]; other site
755178002196	UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289
755178002197	UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351
755178002198	active site
755178002199	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
755178002200	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
755178002201	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080
755178002202	dimer interface [polypeptide binding]; other site
755178002203	phosphorylation site [posttranslational modification]
755178002204	putative acetyltransferase; Provisional; Region: PRK03624
755178002205	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
755178002206	Coenzyme A binding pocket [chemical binding]; other site
755178002207	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
755178002208	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
755178002209	active site
755178002210	phosphorylation site [posttranslational modification]
755178002211	intermolecular recognition site; other site
755178002212	dimerization interface [polypeptide binding]; other site
755178002213	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
755178002214	DNA binding site [nucleotide binding]
755178002215	Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760
755178002216	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
755178002217	Peptidase M1 family Aminopeptidase N; Region: M1_APN_4; cd09603
755178002218	Aminopeptidase N [Amino acid transport and metabolism]; Region: PepN; COG0308
755178002219	Zn binding site [ion binding]; other site
755178002220	Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: COG2402
755178002221	ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565
755178002222	thiS-thiF/thiG interaction site; other site
755178002223	Ferredoxin thioredoxin reductase catalytic beta chain; Region: FeThRed_B; cl01977
755178002224	Protein of unknown function (DUF1230); Region: DUF1230; pfam06799
755178002225	Oligomerisation domain; Region: Oligomerisation; pfam02410
755178002226	Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312
755178002227	Tetratricopeptide repeat; Region: TPR_12; pfam13424
755178002228	Protein of unknown function, DUF481; Region: DUF481; cl01213
755178002229	Protoheme ferro-lyase (ferrochelatase) [Coenzyme metabolism]; Region: HemH; COG0276
755178002230	Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411
755178002231	C-terminal domain interface [polypeptide binding]; other site
755178002232	active site
755178002233	Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419
755178002234	active site
755178002235	N-terminal domain interface [polypeptide binding]; other site
755178002236	RNA polymerase sigma factor, cyanobacterial RpoD-like family; Region: Sig70-cyanoRpoD; TIGR02997
755178002237	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
755178002238	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
755178002239	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
755178002240	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
755178002241	DNA binding residues [nucleotide binding]
755178002242	CoA binding domain; Region: CoA_binding; cl17356
755178002243	Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607
755178002244	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447
755178002245	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670
755178002246	1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436
755178002247	DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288
755178002248	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
755178002249	metal binding site 2 [ion binding]; metal-binding site
755178002250	putative DNA binding helix; other site
755178002251	metal binding site 1 [ion binding]; metal-binding site
755178002252	dimer interface [polypeptide binding]; other site
755178002253	structural Zn2+ binding site [ion binding]; other site
755178002254	Ferredoxin [Energy production and conversion]; Region: COG1146
755178002255	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
755178002256	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
755178002257	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
755178002258	Walker A/P-loop; other site
755178002259	ATP binding site [chemical binding]; other site
755178002260	Q-loop/lid; other site
755178002261	ABC transporter signature motif; other site
755178002262	Walker B; other site
755178002263	D-loop; other site
755178002264	H-loop/switch region; other site
755178002265	Mechanosensitive ion channel; Region: MS_channel; pfam00924
755178002266	UDP-N-acetylglucosamine 2-epimerase; Region: wecB; TIGR00236
755178002267	Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase  family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786
755178002268	active site
755178002269	homodimer interface [polypeptide binding]; other site
755178002270	phosphoglucosamine mutase; Provisional; Region: glmM; PRK14317
755178002271	GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802
755178002272	active site
755178002273	substrate binding site [chemical binding]; other site
755178002274	metal binding site [ion binding]; metal-binding site
755178002275	ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575
755178002276	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
755178002277	Coenzyme A binding pocket [chemical binding]; other site
755178002278	1,4-alpha-glucan branching enzyme [Carbohydrate transport and metabolism]; Region: GlgB; COG0296
755178002279	N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855
755178002280	Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322
755178002281	active site
755178002282	catalytic site [active]
755178002283	Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806
755178002284	Phage uncharacterized protein (Phage_XkdX); Region: Phage_XkdX; cl09900
755178002285	succinate dehydrogenase iron-sulfur subunit; Provisional; Region: PRK12577
755178002286	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
755178002287	catalytic loop [active]
755178002288	iron binding site [ion binding]; other site
755178002289	AbrB-like transcriptional regulator; Region: AbrB-like; pfam14250
755178002290	CAAX protease self-immunity; Region: Abi; pfam02517
755178002291	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
755178002292	active site
755178002293	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
755178002294	core domain interface [polypeptide binding]; other site
755178002295	delta subunit interface [polypeptide binding]; other site
755178002296	epsilon subunit interface [polypeptide binding]; other site
755178002297	ATP synthase CF1 alpha subunit; Region: atpA; CHL00059
755178002298	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
755178002299	F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
755178002300	beta subunit interaction interface [polypeptide binding]; other site
755178002301	Walker A motif; other site
755178002302	ATP binding site [chemical binding]; other site
755178002303	Walker B motif; other site
755178002304	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
755178002305	F0F1-type ATP synthase, delta subunit (mitochondrial oligomycin sensitivity protein) [Energy production and conversion]; Region: AtpH; cl17210
755178002306	ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213
755178002307	F0F1 ATP synthase subunit B; Validated; Region: PRK07352
755178002308	ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192
755178002309	F0F1 ATP synthase subunit B'; Validated; Region: PRK07353
755178002310	ATP synthase B/B' CF(0); Region: ATP-synt_B; pfam00430
755178002311	ATP synthase CF0 C subunit; Region: atpH; CHL00061
755178002312	ATP synthase CF0 A subunit; Region: atpI; CHL00046
755178002313	F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356
755178002314	ATP synthase I chain; Region: ATP_synt_I; pfam03899
755178002315	PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812
755178002316	Rrf2 family protein; Region: rrf2_super; TIGR00738
755178002317	Transcriptional regulator; Region: Rrf2; cl17282
755178002318	signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416
755178002319	SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881
755178002320	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
755178002321	P loop; other site
755178002322	GTP binding site [chemical binding]; other site
755178002323	RNA polymerase sigma factor; Provisional; Region: PRK12518
755178002324	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
755178002325	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
755178002326	DNA binding residues [nucleotide binding]
755178002327	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
755178002328	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
755178002329	Probable transposase; Region: OrfB_IS605; pfam01385
755178002330	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
755178002331	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
755178002332	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
755178002333	active site
755178002334	Protein of unknown function (DUF3252); Region: DUF3252; pfam11623
755178002335	Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793
755178002336	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
755178002337	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
755178002338	protein binding site [polypeptide binding]; other site
755178002339	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
755178002340	Catalytic dyad [active]
755178002341	Protein of unknown function (DUF3124); Region: DUF3124; pfam11322
755178002342	tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795
755178002343	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
755178002344	binding surface
755178002345	Tetratricopeptide repeat; Region: TPR_16; pfam13432
755178002346	TPR motif; other site
755178002347	tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795
755178002348	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
755178002349	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
755178002350	N-acetyl-D-glucosamine binding site [chemical binding]; other site
755178002351	catalytic residue [active]
755178002352	ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747
755178002353	UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331
755178002354	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186
755178002355	Response regulator receiver domain; Region: Response_reg; pfam00072
755178002356	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
755178002357	active site
755178002358	phosphorylation site [posttranslational modification]
755178002359	intermolecular recognition site; other site
755178002360	dimerization interface [polypeptide binding]; other site
755178002361	PAS domain; Region: PAS_9; pfam13426
755178002362	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
755178002363	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
755178002364	metal binding site [ion binding]; metal-binding site
755178002365	active site
755178002366	I-site; other site
755178002367	Cache domain; Region: Cache_1; pfam02743
755178002368	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
755178002369	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
755178002370	dimerization interface [polypeptide binding]; other site
755178002371	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
755178002372	dimer interface [polypeptide binding]; other site
755178002373	phosphorylation site [posttranslational modification]
755178002374	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
755178002375	ATP binding site [chemical binding]; other site
755178002376	Mg2+ binding site [ion binding]; other site
755178002377	G-X-G motif; other site
755178002378	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
755178002379	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
755178002380	active site
755178002381	phosphorylation site [posttranslational modification]
755178002382	intermolecular recognition site; other site
755178002383	dimerization interface [polypeptide binding]; other site
755178002384	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
755178002385	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
755178002386	phosphopeptide binding site; other site
755178002387	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
755178002388	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
755178002389	putative active site [active]
755178002390	heme pocket [chemical binding]; other site
755178002391	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
755178002392	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
755178002393	metal binding site [ion binding]; metal-binding site
755178002394	active site
755178002395	I-site; other site
755178002396	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
755178002397	Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405
755178002398	active site
755178002399	photosystem I reaction center subunit PsaK; Region: PS_I_psaK; TIGR03049
755178002400	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
755178002401	Glucose-6-phosphate dehydrogenase subunit; Region: OpcA_G6PD_assem; cl01359
755178002402	glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722
755178002403	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
755178002404	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
755178002405	acyl carrier protein; Provisional; Region: acpP; PRK00982
755178002406	beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150
755178002407	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
755178002408	dimer interface [polypeptide binding]; other site
755178002409	active site
755178002410	Protein of unknown function (DUF3750); Region: DUF3750; pfam12570
755178002411	HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis.  HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197
755178002412	dimerization interface [polypeptide binding]; other site
755178002413	hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124
755178002414	ATP binding site [chemical binding]; other site
755178002415	DEP domain, named after Dishevelled, Egl-10, and Pleckstrin, where this domain was first discovered. The function of this domain is still not clear, but it is believed to be important for the membrane association of the signaling proteins in which it is...; Region: DEP; cd04371
755178002416	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
755178002417	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
755178002418	mercuric reductase; Validated; Region: PRK06370
755178002419	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
755178002420	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
755178002421	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
755178002422	catalytic core [active]
755178002423	Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of  glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570
755178002424	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
755178002425	C-terminal domain interface [polypeptide binding]; other site
755178002426	GSH binding site (G-site) [chemical binding]; other site
755178002427	dimer interface [polypeptide binding]; other site
755178002428	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776
755178002429	N-terminal domain interface [polypeptide binding]; other site
755178002430	Phycobilisome protein; Region: Phycobilisome; cl08227
755178002431	DNA gyrase subunit A; Validated; Region: PRK05560
755178002432	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
755178002433	CAP-like domain; other site
755178002434	active site
755178002435	primary dimer interface [polypeptide binding]; other site
755178002436	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
755178002437	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
755178002438	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
755178002439	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
755178002440	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
755178002441	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
755178002442	Predicted protease with the C-terminal PDZ domain [General function prediction only]; Region: COG3975
755178002443	M61 glycyl aminopeptidase; Region: Peptidase_M61; pfam05299
755178002444	PDZ domain associated with archaeal and bacterial M61 glycyl-aminopeptidases. May be responsible for substrate recognition and/or binding, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) polypeptides and even to...; Region: PDZ_glycyl_aminopeptidase; cd00990
755178002445	protein binding site [polypeptide binding]; other site
755178002446	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905
755178002447	FAD binding domain; Region: FAD_binding_4; pfam01565
755178002448	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
755178002449	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
755178002450	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
755178002451	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
755178002452	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
755178002453	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
755178002454	binding surface
755178002455	TPR motif; other site
755178002456	Beta-lactamase class A [Defense mechanisms]; Region: PenP; COG2367
755178002457	Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354
755178002458	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
755178002459	Esterase-like activity of phytase; Region: Phytase-like; pfam13449
755178002460	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4246
755178002461	PemK-like protein; Region: PemK; pfam02452
755178002462	preprotein translocase subunit SecA; Reviewed; Region: secA; PRK12902
755178002463	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
755178002464	ATP binding site [chemical binding]; other site
755178002465	putative Mg++ binding site [ion binding]; other site
755178002466	SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958
755178002467	Tetratricopeptide repeat; Region: TPR_16; pfam13432
755178002468	CpeS-like protein; Region: CpeS; pfam09367
755178002469	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
755178002470	putative trimer interface [polypeptide binding]; other site
755178002471	putative CoA binding site [chemical binding]; other site
755178002472	Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663
755178002473	Gamma carbonic anhydrases (CA): Carbonic anhydrases are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism, involving the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide, followed...; Region: LbH_gamma_CA; cd00710
755178002474	trimer interface [polypeptide binding]; other site
755178002475	active site
755178002476	Ribulose bisphosphate carboxylase/oxygenase (Rubisco), small subunit and related proteins. Rubisco is a bifunctional enzyme catalyzes the initial steps of two opposing metabolic pathways: photosynthetic carbon fixation and the competing process of...; Region: RuBisCO_small_like; cd00307
755178002477	putative multimerization interface [polypeptide binding]; other site
755178002478	Ribulose bisphosphate carboxylase/oxygenase (Rubisco), small subunit and related proteins. Rubisco is a bifunctional enzyme catalyzes the initial steps of two opposing metabolic pathways: photosynthetic carbon fixation and the competing process of...; Region: RuBisCO_small_like; cd00307
755178002479	putative multimerization interface [polypeptide binding]; other site
755178002480	Ribulose bisphosphate carboxylase/oxygenase (Rubisco), small subunit and related proteins. Rubisco is a bifunctional enzyme catalyzes the initial steps of two opposing metabolic pathways: photosynthetic carbon fixation and the competing process of...; Region: RuBisCO_small_like; cd00307
755178002481	putative multimerization interface [polypeptide binding]; other site
755178002482	Ribulose bisphosphate carboxylase/oxygenase (Rubisco), small subunit and related proteins. Rubisco is a bifunctional enzyme catalyzes the initial steps of two opposing metabolic pathways: photosynthetic carbon fixation and the competing process of...; Region: RuBisCO_small_like; cd00307
755178002483	putative multimerization interface [polypeptide binding]; other site
755178002484	Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614
755178002485	Hexamer/Pentamer interface [polypeptide binding]; other site
755178002486	central pore; other site
755178002487	Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577
755178002488	Carbon dioxide concentrating mechanism (CcmK); Bacterial Micro-Compartment (BCM) domain; Region: BMC_CcmK; cd07057
755178002489	Hexamer interface [polypeptide binding]; other site
755178002490	Hexagonal pore residue; other site
755178002491	Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577
755178002492	Carbon dioxide concentrating mechanism (CcmK); Bacterial Micro-Compartment (BCM) domain; Region: BMC_CcmK; cd07057
755178002493	Hexamer interface [polypeptide binding]; other site
755178002494	Hexagonal pore residue; other site
755178002495	UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087
755178002496	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
755178002497	NAD binding site [chemical binding]; other site
755178002498	homodimer interface [polypeptide binding]; other site
755178002499	active site
755178002500	substrate binding site [chemical binding]; other site
755178002501	four helix bundle protein; Region: TIGR02436
755178002502	S23 ribosomal protein; Region: Ribosomal_S23p; cl05287
755178002503	peptide chain release factor 3; Provisional; Region: prfC; PRK00741
755178002504	Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169
755178002505	G1 box; other site
755178002506	putative GEF interaction site [polypeptide binding]; other site
755178002507	GTP/Mg2+ binding site [chemical binding]; other site
755178002508	Switch I region; other site
755178002509	G2 box; other site
755178002510	G3 box; other site
755178002511	Switch II region; other site
755178002512	G4 box; other site
755178002513	G5 box; other site
755178002514	RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689
755178002515	D1 subunit  of photosystem II (PS II); Region: Photosystem-II_D1; cd09289
755178002516	protein I interface; other site
755178002517	D2 interface; other site
755178002518	protein T interface; other site
755178002519	chlorophyll binding site; other site
755178002520	beta carotene binding site; other site
755178002521	pheophytin binding site; other site
755178002522	manganese-stabilizing polypeptide interface; other site
755178002523	CP43 interface; other site
755178002524	protein L interface; other site
755178002525	oxygen evolving complex binding site; other site
755178002526	bromide binding site; other site
755178002527	quinone binding site; other site
755178002528	Fe binding site [ion binding]; other site
755178002529	core light harvesting interface; other site
755178002530	cytochrome b559 alpha subunit interface; other site
755178002531	cytochrome c-550 interface; other site
755178002532	protein J interface; other site
755178002533	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
755178002534	putative binding surface; other site
755178002535	active site
755178002536	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
755178002537	putative binding surface; other site
755178002538	active site
755178002539	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
755178002540	putative binding surface; other site
755178002541	active site
755178002542	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
755178002543	putative binding surface; other site
755178002544	active site
755178002545	Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895
755178002546	Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643
755178002547	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
755178002548	ATP binding site [chemical binding]; other site
755178002549	Mg2+ binding site [ion binding]; other site
755178002550	G-X-G motif; other site
755178002551	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256
755178002552	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
755178002553	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
755178002554	active site
755178002555	phosphorylation site [posttranslational modification]
755178002556	intermolecular recognition site; other site
755178002557	dimerization interface [polypeptide binding]; other site
755178002558	phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168
755178002559	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
755178002560	active site
755178002561	(T/H)XGH motif; other site
755178002562	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
755178002563	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
755178002564	catalytic residues [active]
755178002565	Predicted membrane protein [Function unknown]; Region: COG4094
755178002566	LysR transcriptional regulator; Provisional; Region: rbcR; CHL00180
755178002567	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
755178002568	C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420
755178002569	putative dimerization interface [polypeptide binding]; other site
755178002570	GTPase SAR1 and related small G proteins [General function prediction only]; Region: COG1100
755178002571	E. coli Ras-like protein (Era)-like GTPase; Region: Era_like; cd00880
755178002572	G1 box; other site
755178002573	GTP/Mg2+ binding site [chemical binding]; other site
755178002574	Switch I region; other site
755178002575	G2 box; other site
755178002576	Switch II region; other site
755178002577	G3 box; other site
755178002578	G4 box; other site
755178002579	G5 box; other site
755178002580	Domain of unknown function (DUF697); Region: DUF697; pfam05128
755178002581	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231
755178002582	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
755178002583	TPR motif; other site
755178002584	binding surface
755178002585	Response regulator receiver domain; Region: Response_reg; pfam00072
755178002586	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
755178002587	active site
755178002588	phosphorylation site [posttranslational modification]
755178002589	intermolecular recognition site; other site
755178002590	dimerization interface [polypeptide binding]; other site
755178002591	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
755178002592	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
755178002593	metal binding site [ion binding]; metal-binding site
755178002594	active site
755178002595	I-site; other site
755178002596	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
755178002597	putative phosphoketolase; Provisional; Region: PRK05261
755178002598	Thiamine pyrophosphate (TPP) family, Phosphoketolase (PK) subfamily, TPP-binding module; PK catalyzes the conversion of D-xylulose 5-phosphate and phosphate to acetyl phosphate, D-glyceraldehyde-3-phosphate and H2O. This enzyme requires divalent...; Region: TPP_PK; cd02011
755178002599	TPP-binding site; other site
755178002600	XFP C-terminal domain; Region: XFP_C; pfam09363
755178002601	Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349
755178002602	DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142
755178002603	catalytic site [active]
755178002604	putative active site [active]
755178002605	putative substrate binding site [chemical binding]; other site
755178002606	DNA primase; Validated; Region: dnaG; PRK05667
755178002607	CHC2 zinc finger; Region: zf-CHC2; cl17510
755178002608	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
755178002609	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
755178002610	active site
755178002611	metal binding site [ion binding]; metal-binding site
755178002612	interdomain interaction site; other site
755178002613	DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410
755178002614	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
755178002615	active site
755178002616	NTP binding site [chemical binding]; other site
755178002617	metal binding triad [ion binding]; metal-binding site
755178002618	antibiotic binding site [chemical binding]; other site
755178002619	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK02534
755178002620	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
755178002621	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
755178002622	HAS barrel domain; Region: HAS-barrel; pfam09378
755178002623	HerA helicase [Replication, recombination, and repair]; Region: COG0433
755178002624	Domain of unknown function DUF87; Region: DUF87; pfam01935
755178002625	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
755178002626	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
755178002627	Probable transposase; Region: OrfB_IS605; pfam01385
755178002628	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
755178002629	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
755178002630	dimer interface [polypeptide binding]; other site
755178002631	phosphorylation site [posttranslational modification]
755178002632	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
755178002633	ATP binding site [chemical binding]; other site
755178002634	Mg2+ binding site [ion binding]; other site
755178002635	G-X-G motif; other site
755178002636	2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982
755178002637	ABC1 family; Region: ABC1; cl17513
755178002638	Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338
755178002639	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
755178002640	active site
755178002641	homodimer interface [polypeptide binding]; other site
755178002642	catalytic site [active]
755178002643	N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834
755178002644	Amidinotransferase; Region: Amidinotransf; cl12043
755178002645	Uncharacterized conserved protein [Function unknown]; Region: COG1915
755178002646	Saccharopine dehydrogenase N-terminal domain; Region: SDH_N_domain; cd12144
755178002647	homodimer interface [polypeptide binding]; other site
755178002648	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
755178002649	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
755178002650	HlyD family secretion protein; Region: HlyD_3; pfam13437
755178002651	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
755178002652	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
755178002653	metal-binding site [ion binding]
755178002654	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
755178002655	Soluble P-type ATPase [General function prediction only]; Region: COG4087
755178002656	Response regulator receiver domain; Region: Response_reg; pfam00072
755178002657	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
755178002658	active site
755178002659	phosphorylation site [posttranslational modification]
755178002660	intermolecular recognition site; other site
755178002661	dimerization interface [polypeptide binding]; other site
755178002662	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
755178002663	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080
755178002664	phosphorylation site [posttranslational modification]
755178002665	dimer interface [polypeptide binding]; other site
755178002666	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
755178002667	ATP binding site [chemical binding]; other site
755178002668	Mg2+ binding site [ion binding]; other site
755178002669	G-X-G motif; other site
755178002670	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with a PAS domain, a GGDEF (DiGuanylate-Cyclase (DGC) domain, and a DUF1 domain downstream. PAS domains have been found to bind ligands, and to act...; Region: CBS_pair_PAS_GGDEF_DUF1_assoc; cd04611
755178002671	FOG: CBS domain [General function prediction only]; Region: COG0517
755178002672	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
755178002673	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
755178002674	active site
755178002675	phosphorylation site [posttranslational modification]
755178002676	intermolecular recognition site; other site
755178002677	dimerization interface [polypeptide binding]; other site
755178002678	PAS domain; Region: PAS; smart00091
755178002679	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
755178002680	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
755178002681	Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086
755178002682	nitrogen fixation negative regulator NifL; Region: nifL_nitrog; TIGR02938
755178002683	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
755178002684	putative active site [active]
755178002685	heme pocket [chemical binding]; other site
755178002686	PAS domain; Region: PAS_8; pfam13188
755178002687	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
755178002688	dimer interface [polypeptide binding]; other site
755178002689	phosphorylation site [posttranslational modification]
755178002690	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
755178002691	ATP binding site [chemical binding]; other site
755178002692	Mg2+ binding site [ion binding]; other site
755178002693	G-X-G motif; other site
755178002694	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831
755178002695	plasma-membrane proton-efflux P-type ATPase; Region: ATPase-IIIA_H; TIGR01647
755178002696	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
755178002697	Soluble P-type ATPase [General function prediction only]; Region: COG4087
755178002698	(dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14333
755178002699	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
755178002700	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
755178002701	FeS/SAM binding site; other site
755178002702	TRAM domain; Region: TRAM; pfam01938
755178002703	Cysteine desulfurase SufE subunit [Posttranslational modification, protein turnover, chaperones]; Region: sufE; COG2166
755178002704	Uncharacterized family 1; belongs to a superfamily containing the transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this family was previously known as part of DUF156; Region: CsoR-like_DUF156_1; cd10158
755178002705	putative homodimer interface [polypeptide binding]; other site
755178002706	putative homotetramer interface [polypeptide binding]; other site
755178002707	putative metal binding site [ion binding]; other site
755178002708	putative homodimer-homodimer interface [polypeptide binding]; other site
755178002709	putative allosteric switch controlling residues; other site
755178002710	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
755178002711	Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174
755178002712	substrate binding site [chemical binding]; other site
755178002713	dimer interface [polypeptide binding]; other site
755178002714	ATP binding site [chemical binding]; other site
755178002715	Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; cl17496
755178002716	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
755178002717	Coenzyme A binding pocket [chemical binding]; other site
755178002718	GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972
755178002719	GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048
755178002720	C-terminal domain interface [polypeptide binding]; other site
755178002721	GSH binding site (G-site) [chemical binding]; other site
755178002722	dimer interface [polypeptide binding]; other site
755178002723	C-terminal, alpha helical domain of Escherichia coli YfcG Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YfcG_like; cd10291
755178002724	N-terminal domain interface [polypeptide binding]; other site
755178002725	putative dimer interface [polypeptide binding]; other site
755178002726	active site
755178002727	Methyltransferase domain; Region: Methyltransf_23; pfam13489
755178002728	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
755178002729	S-adenosylmethionine binding site [chemical binding]; other site
755178002730	Cupin domain; Region: Cupin_2; pfam07883
755178002731	Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585
755178002732	HflK protein; Region: hflK; TIGR01933
755178002733	Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403
755178002734	Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683
755178002735	active site lid residues [active]
755178002736	substrate binding pocket [chemical binding]; other site
755178002737	catalytic residues [active]
755178002738	substrate-Mg2+ binding site; other site
755178002739	aspartate-rich region 1; other site
755178002740	aspartate-rich region 2; other site
755178002741	phytoene desaturase; Region: phytoene_desat; TIGR02731
755178002742	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
755178002743	[FeFe] hydrogenase, group A; Region: FeFe_hydrog_A; TIGR02512
755178002744	Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cd00232
755178002745	heme binding pocket [chemical binding]; other site
755178002746	heme ligand [chemical binding]; other site
755178002747	putative hydrolase; Provisional; Region: PRK11460
755178002748	Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230
755178002749	circadian clock protein KaiC; Reviewed; Region: PRK09302
755178002750	KaiC is a circadian clock protein primarily found in cyanobacteria KaiC is a RecA-like ATPase, having both Walker A and Walker B motifs. A related protein is found in archaea; Region: KaiC; cd01124
755178002751	Walker A motif; other site
755178002752	ATP binding site [chemical binding]; other site
755178002753	Walker B motif; other site
755178002754	recA bacterial DNA recombination protein; Region: RecA; cl17211
755178002755	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
755178002756	Walker A motif; other site
755178002757	ATP binding site [chemical binding]; other site
755178002758	Walker B motif; other site
755178002759	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
755178002760	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
755178002761	dimer interface [polypeptide binding]; other site
755178002762	conserved gate region; other site
755178002763	putative PBP binding loops; other site
755178002764	ABC-ATPase subunit interface; other site
755178002765	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661
755178002766	putative active site pocket [active]
755178002767	dimerization interface [polypeptide binding]; other site
755178002768	putative catalytic residue [active]
755178002769	glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045
755178002770	NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213
755178002771	tRNA; other site
755178002772	putative tRNA binding site [nucleotide binding]; other site
755178002773	putative NADP binding site [chemical binding]; other site
755178002774	Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745
755178002775	TRAP-type mannitol/chloroaromatic compound transport system, large permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT3; COG4664
755178002776	DctM-like transporters; Region: DctM; pfam06808
755178002777	phycocyanobilin:ferredoxin oxidoreductase; Validated; Region: PRK02816
755178002778	Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086
755178002779	putative catalytic site [active]
755178002780	putative phosphate binding site [ion binding]; other site
755178002781	active site
755178002782	metal binding site A [ion binding]; metal-binding site
755178002783	DNA binding site [nucleotide binding]
755178002784	putative AP binding site [nucleotide binding]; other site
755178002785	putative metal binding site B [ion binding]; other site
755178002786	Uncharacterized ACR, YhhQ family COG1738; Region: DUF165; pfam02592
755178002787	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221
755178002788	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
755178002789	Walker A motif; other site
755178002790	ATP binding site [chemical binding]; other site
755178002791	Walker B motif; other site
755178002792	Polyferredoxin [Energy production and conversion]; Region: NapH; COG0348
755178002793	4Fe-4S binding domain; Region: Fer4_5; pfam12801
755178002794	light-harvesting-like protein 3; Provisional; Region: PLN00014
755178002795	DNA polymerase III subunit delta; Validated; Region: PRK07452
755178002796	DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144
755178002797	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
755178002798	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
755178002799	active site
755178002800	metal binding site [ion binding]; metal-binding site
755178002801	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
755178002802	active site
755178002803	metal binding site [ion binding]; metal-binding site
755178002804	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
755178002805	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
755178002806	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
755178002807	Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733
755178002808	dimer interface [polypeptide binding]; other site
755178002809	motif 1; other site
755178002810	active site
755178002811	motif 2; other site
755178002812	motif 3; other site
755178002813	histidinol-phosphate aminotransferase; Provisional; Region: PRK02610
755178002814	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
755178002815	pyridoxal 5'-phosphate binding site [chemical binding]; other site
755178002816	homodimer interface [polypeptide binding]; other site
755178002817	catalytic residue [active]
755178002818	Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059
755178002819	chromate transporter, chromate ion transporter (CHR) family; Region: 2A51; TIGR00937
755178002820	Chromate transporter; Region: Chromate_transp; pfam02417
755178002821	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_23; cd04682
755178002822	nudix motif; other site
755178002823	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
755178002824	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
755178002825	catalytic loop [active]
755178002826	iron binding site [ion binding]; other site
755178002827	Uncharacterized protein involved in tolerance to divalent cations [Inorganic ion transport and metabolism]; Region: CutA; COG1324
755178002828	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
755178002829	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
755178002830	P-loop; other site
755178002831	Magnesium ion binding site [ion binding]; other site
755178002832	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
755178002833	Magnesium ion binding site [ion binding]; other site
755178002834	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
755178002835	This family is most closely related to the GT1 family of glycosyltransferases. ExpC in Rhizobium meliloti has been shown to be involved in the biosynthesis of galactoglucan (exopolysaccharide II); Region: GT1_ExpC_like; cd03818
755178002836	putative ADP-binding pocket [chemical binding]; other site
755178002837	Uncharacterized conserved protein [Function unknown]; Region: COG3542
755178002838	2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563
755178002839	precorrin-8X methylmutase; Provisional; Region: PRK05954
755178002840	Precorrin-8X methylmutase; Region: CbiC; pfam02570
755178002841	N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742
755178002842	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
755178002843	S-adenosylmethionine binding site [chemical binding]; other site
755178002844	Response regulator receiver domain; Region: Response_reg; pfam00072
755178002845	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
755178002846	active site
755178002847	phosphorylation site [posttranslational modification]
755178002848	intermolecular recognition site; other site
755178002849	Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208
755178002850	dimerization interface [polypeptide binding]; other site
755178002851	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
755178002852	Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157
755178002853	Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804
755178002854	PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129
755178002855	Walker A motif; other site
755178002856	ATP binding site [chemical binding]; other site
755178002857	Walker B motif; other site
755178002858	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
755178002859	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
755178002860	Probable transposase; Region: OrfB_IS605; pfam01385
755178002861	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
755178002862	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
755178002863	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
755178002864	[2Fe-2S] cluster binding site [ion binding]; other site
755178002865	P-aminobenzoate N-oxygenase AurF; Region: AurF; pfam11583
755178002866	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
755178002867	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
755178002868	catalytic loop [active]
755178002869	iron binding site [ion binding]; other site
755178002870	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
755178002871	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
755178002872	[2Fe-2S] cluster binding site [ion binding]; other site
755178002873	Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000
755178002874	Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116
755178002875	Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110
755178002876	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
755178002877	putative trimer interface [polypeptide binding]; other site
755178002878	putative CoA binding site [chemical binding]; other site
755178002879	GH3 auxin-responsive promoter; Region: GH3; pfam03321
755178002880	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
755178002881	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
755178002882	Probable transposase; Region: OrfB_IS605; pfam01385
755178002883	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
755178002884	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
755178002885	Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499
755178002886	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
755178002887	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
755178002888	active site
755178002889	metal binding site [ion binding]; metal-binding site
755178002890	MEKHLA domain; Region: MEKHLA; pfam08670
755178002891	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
755178002892	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
755178002893	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
755178002894	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
755178002895	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
755178002896	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
755178002897	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
755178002898	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
755178002899	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
755178002900	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
755178002901	dimer interface [polypeptide binding]; other site
755178002902	conserved gate region; other site
755178002903	putative PBP binding loops; other site
755178002904	ABC-ATPase subunit interface; other site
755178002905	Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897
755178002906	Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448
755178002907	active site residue [active]
755178002908	Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449
755178002909	active site residue [active]
755178002910	Uncharacterized conserved protein [Function unknown]; Region: COG1432
755178002911	LabA_like proteins; Region: LabA; cd10911
755178002912	putative metal binding site [ion binding]; other site
755178002913	Uncharacterized protein conserved in archaea [Posttranslational modification, protein turnover, chaperones]; Region: COG4067
755178002914	RDD family; Region: RDD; pfam06271
755178002915	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02705
755178002916	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
755178002917	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
755178002918	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
755178002919	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
755178002920	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
755178002921	catalytic residue [active]
755178002922	Ycf39; Provisional; Region: ycf39; CHL00194
755178002923	atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243
755178002924	NAD(P) binding site [chemical binding]; other site
755178002925	putative active site [active]
755178002926	Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760
755178002927	Cobalamin biosynthesis central region; Region: CbiG_mid; pfam11761
755178002928	Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890
755178002929	Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646
755178002930	active site
755178002931	SAM binding site [chemical binding]; other site
755178002932	homodimer interface [polypeptide binding]; other site
755178002933	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
755178002934	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
755178002935	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
755178002936	Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236
755178002937	Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706
755178002938	Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492
755178002939	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
755178002940	Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013
755178002941	catalytic triad [active]
755178002942	dimer interface [polypeptide binding]; other site
755178002943	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
755178002944	metal binding site 2 [ion binding]; metal-binding site
755178002945	putative DNA binding helix; other site
755178002946	metal binding site 1 [ion binding]; metal-binding site
755178002947	dimer interface [polypeptide binding]; other site
755178002948	structural Zn2+ binding site [ion binding]; other site
755178002949	CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725
755178002950	CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cd09634
755178002951	Predicted integral membrane protein [Function unknown]; Region: COG0392
755178002952	Aldose 1-epimerase, similar to Synechocystis Slr1438; Region: Aldose_epim_Slr1438; cd09025
755178002953	active site
755178002954	catalytic residues [active]
755178002955	Dolichol kinase [Lipid metabolism]; Region: SEC59; COG0170
755178002956	putative bicarbonate transporter, IctB family; Region: 2A73; TIGR00947
755178002957	Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307
755178002958	hydrolase, alpha/beta fold family protein; Region: PLN02824
755178002959	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
755178002960	dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254
755178002961	RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321
755178002962	NADP binding site [chemical binding]; other site
755178002963	active site
755178002964	putative substrate binding site [chemical binding]; other site
755178002965	Protein of unknown function DUF82; Region: DUF82; pfam01927
755178002966	Protein of unknown function (DUF433); Region: DUF433; pfam04255
755178002967	Protein of unknown function (DUF3177); Region: DUF3177; pfam11375
755178002968	CP12 domain; Region: CP12; pfam02672
755178002969	mttA/Hcf106 family; Region: MttA_Hcf106; cl00788
755178002970	3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK05952
755178002971	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
755178002972	dimer interface [polypeptide binding]; other site
755178002973	active site
755178002974	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cl00197
755178002975	active site
755178002976	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
755178002977	Ligand Binding Site [chemical binding]; other site
755178002978	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
755178002979	Ligand Binding Site [chemical binding]; other site
755178002980	phosphodiesterase YaeI; Provisional; Region: PRK11340
755178002981	Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385
755178002982	putative active site [active]
755178002983	putative metal binding site [ion binding]; other site
755178002984	Predicted membrane protein [Function unknown]; Region: XynA; COG2314
755178002985	Short C-terminal domain; Region: SHOCT; pfam09851
755178002986	Domain of unknown function (DUF1825); Region: DUF1825; pfam08855
755178002987	Protein of unknown function (DUF760); Region: DUF760; pfam05542
755178002988	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2343
755178002989	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
755178002990	NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181
755178002991	active site
755178002992	Substrate binding site; other site
755178002993	Mg++ binding site; other site
755178002994	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
755178002995	putative trimer interface [polypeptide binding]; other site
755178002996	putative CoA binding site [chemical binding]; other site
755178002997	Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109
755178002998	GTP-mannose-1-phosphate guanyltransferase (MPG1 transferase), also known as GDP-mannose pyrophosphorylase, is a bifunctional enzyme with both phosphomannose isomerase (PMI) activity and GDP-mannose phosphorylase (GMP) activity.  The protein contains an...; Region: MPG1_transferase; cd05805
755178002999	Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818
755178003000	para-aminobenzoate synthase component II; Provisional; Region: PRK08857
755178003001	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
755178003002	glutamine binding [chemical binding]; other site
755178003003	catalytic triad [active]
755178003004	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
755178003005	Beta-lactamase superfamily domain; Region: Lactamase_B_3; pfam13483
755178003006	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
755178003007	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
755178003008	dimer interface [polypeptide binding]; other site
755178003009	conserved gate region; other site
755178003010	putative PBP binding loops; other site
755178003011	ABC-ATPase subunit interface; other site
755178003012	Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340
755178003013	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057
755178003014	Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402
755178003015	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
755178003016	active site
755178003017	metal binding site [ion binding]; metal-binding site
755178003018	hexamer interface [polypeptide binding]; other site
755178003019	SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. In this subgroup, SpoIVFB (sporulation protein, stage IV cell...; Region: S2P-M50_SpoIVFB_CBS; cd06164
755178003020	Peptidase family M50; Region: Peptidase_M50; pfam02163
755178003021	active site
755178003022	putative substrate binding region [chemical binding]; other site
755178003023	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
755178003024	DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]; Region: DnaJ; COG0484
755178003025	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
755178003026	HSP70 interaction site [polypeptide binding]; other site
755178003027	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
755178003028	dimer interface [polypeptide binding]; other site
755178003029	Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793
755178003030	C-terminal processing peptidase family S41; Region: Peptidase_S41; cd06567
755178003031	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
755178003032	protein binding site [polypeptide binding]; other site
755178003033	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
755178003034	Catalytic dyad [active]
755178003035	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
755178003036	DNA-binding interface [nucleotide binding]; DNA binding site
755178003037	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
755178003038	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988
755178003039	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
755178003040	catalytic site [active]
755178003041	subunit interface [polypeptide binding]; other site
755178003042	Complex I intermediate-associated protein 30 (CIA30); Region: CIA30; pfam08547
755178003043	Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785
755178003044	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; pfam02683
755178003045	cytochrome b6-f complex iron-sulfur subunit; Provisional; Region: PRK13474
755178003046	Cytochrome B6-F complex Fe-S subunit; Region: CytB6-F_Fe-S; pfam08802
755178003047	Iron-sulfur protein (ISP) component of the b6f complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The cytochrome b6f complex from Mastigocladus laminosus, a thermophilic cyanobacterium; Region: Rieske_cytochrome_b6f; cd03471
755178003048	cytochrome b subunit interaction site [polypeptide binding]; other site
755178003049	[2Fe-2S] cluster binding site [ion binding]; other site
755178003050	Protein of unknown function (DUF2892); Region: DUF2892; pfam11127
755178003051	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
755178003052	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
755178003053	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
755178003054	TrkA-N domain; Region: TrkA_N; pfam02254
755178003055	TrkA-C domain; Region: TrkA_C; pfam02080
755178003056	Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168
755178003057	potassium uptake protein, TrkH family; Region: 2a38; TIGR00933
755178003058	PAP-phosphatase_like domains. PAP-phosphatase is a member of the inositol monophosphatase family, and catalyses the hydrolysis of 3'-phosphoadenosine-5'-phosphate (PAP) to AMP. In Saccharomyces cerevisiae, HAL2 (MET22) is involved in methionine...; Region: PAP_phosphatase; cd01517
755178003059	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
755178003060	active site
755178003061	putative lithium-binding site [ion binding]; other site
755178003062	substrate binding site [chemical binding]; other site
755178003063	ribosome maturation protein RimP; Reviewed; Region: PRK00092
755178003064	Sm and related proteins; Region: Sm_like; cl00259
755178003065	Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734
755178003066	putative oligomer interface [polypeptide binding]; other site
755178003067	putative RNA binding site [nucleotide binding]; other site
755178003068	transcription elongation factor NusA; Provisional; Region: nusA; PRK12327
755178003069	NusA N-terminal domain; Region: NusA_N; pfam08529
755178003070	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
755178003071	RNA binding site [nucleotide binding]; other site
755178003072	homodimer interface [polypeptide binding]; other site
755178003073	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
755178003074	G-X-X-G motif; other site
755178003075	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
755178003076	G-X-X-G motif; other site
755178003077	Protein of unknown function (DUF448); Region: DUF448; pfam04296
755178003078	putative RNA binding cleft [nucleotide binding]; other site
755178003079	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
755178003080	translation initiation factor IF-2; Region: IF-2; TIGR00487
755178003081	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
755178003082	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
755178003083	G1 box; other site
755178003084	putative GEF interaction site [polypeptide binding]; other site
755178003085	GTP/Mg2+ binding site [chemical binding]; other site
755178003086	Switch I region; other site
755178003087	G2 box; other site
755178003088	G3 box; other site
755178003089	Switch II region; other site
755178003090	G4 box; other site
755178003091	G5 box; other site
755178003092	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
755178003093	Translation-initiation factor 2; Region: IF-2; pfam11987
755178003094	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
755178003095	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
755178003096	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
755178003097	HlyD family secretion protein; Region: HlyD_3; pfam13437
755178003098	The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915
755178003099	Protein export membrane protein; Region: SecD_SecF; cl14618
755178003100	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
755178003101	extended (e) SDRs; Region: SDR_e; cd08946
755178003102	NAD(P) binding site [chemical binding]; other site
755178003103	active site
755178003104	substrate binding site [chemical binding]; other site
755178003105	mannosyl-3-phosphoglycerate phosphatase; Reviewed; Region: PRK00192
755178003106	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
755178003107	active site
755178003108	motif I; other site
755178003109	motif II; other site
755178003110	Domain of unknown function (DUF4327); Region: DUF4327; pfam14217
755178003111	ribosomal protein S6 modification protein; Provisional; Region: PRK10446
755178003112	RimK-like ATP-grasp domain; Region: RimK; pfam08443
755178003113	histidinol-phosphate phosphatase family domain; Region: Histidinol-ppas; TIGR01656
755178003114	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
755178003115	active site
755178003116	motif I; other site
755178003117	motif II; other site
755178003118	This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809
755178003119	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
755178003120	methionine sulfoxide reductase B; Provisional; Region: PRK00222
755178003121	SelR domain; Region: SelR; pfam01641
755178003122	bifunctional sterol desaturase/short chain dehydrogenase; Validated; Region: PRK07424
755178003123	Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116
755178003124	short chain dehydrogenase; Provisional; Region: PRK12367
755178003125	NAD(P) binding site [chemical binding]; other site
755178003126	Preprotein translocase SecG subunit; Region: SecG; cl09123
755178003127	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
755178003128	30S subunit binding site; other site
755178003129	S-adenosylmethionine decarboxylase proenzyme, Bacillus form; Region: SAM_DCase_Bsu; TIGR03330
755178003130	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
755178003131	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
755178003132	Walker A/P-loop; other site
755178003133	ATP binding site [chemical binding]; other site
755178003134	Q-loop/lid; other site
755178003135	ABC transporter signature motif; other site
755178003136	Walker B; other site
755178003137	D-loop; other site
755178003138	H-loop/switch region; other site
755178003139	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
755178003140	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
755178003141	Walker A/P-loop; other site
755178003142	ATP binding site [chemical binding]; other site
755178003143	Q-loop/lid; other site
755178003144	ABC transporter signature motif; other site
755178003145	Walker B; other site
755178003146	D-loop; other site
755178003147	H-loop/switch region; other site
755178003148	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
755178003149	glycogen branching enzyme; Provisional; Region: PRK05402
755178003150	N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855
755178003151	Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322
755178003152	active site
755178003153	catalytic site [active]
755178003154	Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806
755178003155	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
755178003156	M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886
755178003157	metal binding site [ion binding]; metal-binding site
755178003158	dimer interface [polypeptide binding]; other site
755178003159	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
755178003160	Predicted oxidoreductases of the aldo/keto reductase family [General function prediction only]; Region: COG1453
755178003161	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
755178003162	active site
755178003163	catalytic tetrad [active]
755178003164	Bifunctional nuclease; Region: DNase-RNase; pfam02577
755178003165	N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820
755178003166	N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854
755178003167	active site
755178003168	dimer interface [polypeptide binding]; other site
755178003169	Domains in Na-Ca exchangers and integrin-beta4; Region: Calx_beta; smart00237
755178003170	Integrin alpha (beta-propellor repeats); Region: Int_alpha; smart00191
755178003171	Integrin alpha (beta-propellor repeats); Region: Int_alpha; smart00191
755178003172	Integrin alpha (beta-propellor repeats); Region: Int_alpha; smart00191
755178003173	FG-GAP repeat; Region: FG-GAP; cl15299
755178003174	Integrin alpha (beta-propellor repeats); Region: Int_alpha; smart00191
755178003175	5-histidylcysteine sulfoxide synthase; Region: ovoA_Nterm; TIGR04344
755178003176	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
755178003177	DDE superfamily endonuclease; Region: DDE_3; pfam13358
755178003178	Homeodomain-like domain; Region: HTH_23; pfam13384
755178003179	Winged helix-turn helix; Region: HTH_29; pfam13551
755178003180	DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783
755178003181	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
755178003182	dimerization interface [polypeptide binding]; other site
755178003183	DPS ferroxidase diiron center [ion binding]; other site
755178003184	ion pore; other site
755178003185	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
755178003186	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
755178003187	active site
755178003188	phosphorylation site [posttranslational modification]
755178003189	intermolecular recognition site; other site
755178003190	dimerization interface [polypeptide binding]; other site
755178003191	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
755178003192	DNA binding residues [nucleotide binding]
755178003193	dimerization interface [polypeptide binding]; other site
755178003194	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
755178003195	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
755178003196	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
755178003197	dimer interface [polypeptide binding]; other site
755178003198	motif 1; other site
755178003199	active site
755178003200	motif 2; other site
755178003201	motif 3; other site
755178003202	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
755178003203	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
755178003204	active site
755178003205	ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192
755178003206	Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318
755178003207	Phosphoglycerate kinase; Region: PGK; pfam00162
755178003208	substrate binding site [chemical binding]; other site
755178003209	hinge regions; other site
755178003210	ADP binding site [chemical binding]; other site
755178003211	catalytic site [active]
755178003212	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
755178003213	Ligand Binding Site [chemical binding]; other site
755178003214	translation initiation factor IF-3; Reviewed; Region: infC; PRK00028
755178003215	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
755178003216	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
755178003217	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
755178003218	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
755178003219	TM-ABC transporter signature motif; other site
755178003220	Band_7_prohibitin. A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup group includes proteins similar to prohibitin (a lipid raft-associated integral membrane protein).  Individual proteins of this band 7 domain family may...; Region: Band_7_prohibitin; cd03401
755178003221	HflK protein; Region: hflK; TIGR01933
755178003222	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
755178003223	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
755178003224	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
755178003225	TM-ABC transporter signature motif; other site
755178003226	Cupin superfamily protein; Region: Cupin_4; pfam08007
755178003227	Cupin-like domain; Region: Cupin_8; pfam13621
755178003228	type 2 lantibiotic biosynthesis protein LanM; Region: lanti_2_LanM; TIGR03897
755178003229	LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cl04955
755178003230	active site
755178003231	zinc binding site [ion binding]; other site
755178003232	Nitrogen fixation protein of unknown function; Region: Nif11; pfam07862
755178003233	Nitrogen fixation protein of unknown function; Region: Nif11; pfam07862
755178003234	Nitrogen fixation protein of unknown function; Region: Nif11; pfam07862
755178003235	Nitrogen fixation protein of unknown function; Region: Nif11; pfam07862
755178003236	Nitrogen fixation protein of unknown function; Region: Nif11; pfam07862
755178003237	Nitrogen fixation protein of unknown function; Region: Nif11; pfam07862
755178003238	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
755178003239	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
755178003240	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640
755178003241	Prolyl 4-hydroxylase alpha subunit homologues; Region: P4Hc; smart00702
755178003242	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
755178003243	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
755178003244	NAD(P) binding site [chemical binding]; other site
755178003245	putative addiction module antidote; Region: doc_partner; TIGR02609
755178003246	Prophage maintenance system killer protein [General function prediction only]; Region: Doc; COG3654
755178003247	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
755178003248	Multicopper oxidase; Region: Cu-oxidase; pfam00394
755178003249	Multicopper oxidase; Region: Cu-oxidase_2; pfam07731
755178003250	Copper resistance protein B precursor (CopB); Region: CopB; pfam05275
755178003251	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
755178003252	phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019
755178003253	ATP-grasp domain; Region: ATP-grasp; pfam02222
755178003254	Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670
755178003255	Retinal pigment epithelial membrane protein; Region: RPE65; pfam03055
755178003256	Domain of unknown function (DUF4359); Region: DUF4359; pfam14271
755178003257	Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835
755178003258	Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835
755178003259	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
755178003260	active site
755178003261	catalytic residues [active]
755178003262	metal binding site [ion binding]; metal-binding site
755178003263	S-layer homology domain; Region: SLH; pfam00395
755178003264	Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966
755178003265	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
755178003266	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
755178003267	polyphosphate:AMP phosphotransferase; Region: poly_P_AMP_trns; TIGR03708
755178003268	Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971
755178003269	Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971
755178003270	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
755178003271	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
755178003272	dimer interface [polypeptide binding]; other site
755178003273	conserved gate region; other site
755178003274	putative PBP binding loops; other site
755178003275	ABC-ATPase subunit interface; other site
755178003276	acyl-ACP reductase; Provisional; Region: PRK14982
755178003277	NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226
755178003278	NAD(P) binding pocket [chemical binding]; other site
755178003279	photosystem II S4 domain protein; Region: PS_II_S4; TIGR03069
755178003280	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
755178003281	RNA binding surface [nucleotide binding]; other site
755178003282	Predicted membrane protein [Function unknown]; Region: COG1971
755178003283	Domain of unknown function DUF; Region: DUF204; pfam02659
755178003284	Uncharacterized conserved protein [Function unknown]; Region: COG5464
755178003285	Protein of unknown function (DUF2887); Region: DUF2887; pfam11103
755178003286	Domain of unknown function (DUF4351); Region: DUF4351; pfam14261
755178003287	UDP-glucose 4 epimerase, subgroup 4, extended (e) SDRs; Region: UDP_G4E_4_SDR_e; cd05232
755178003288	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
755178003289	putative NAD(P) binding site [chemical binding]; other site
755178003290	active site
755178003291	putative substrate binding site [chemical binding]; other site
755178003292	DDE superfamily endonuclease; Region: DDE_4_2; pfam13613
755178003293	DDE superfamily endonuclease; Region: DDE_4; pfam13359
755178003294	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
755178003295	WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433
755178003296	metal-binding site
755178003297	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
755178003298	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
755178003299	sulfotransferase; Region: PLN02164
755178003300	Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685
755178003301	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
755178003302	This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811
755178003303	putative ADP-binding pocket [chemical binding]; other site
755178003304	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
755178003305	S-adenosylmethionine binding site [chemical binding]; other site
755178003306	Sulfotransferase family; Region: Sulfotransfer_3; pfam13469
755178003307	Sulfotransferase family; Region: Sulfotransfer_2; pfam03567
755178003308	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
755178003309	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
755178003310	Walker A/P-loop; other site
755178003311	ATP binding site [chemical binding]; other site
755178003312	Q-loop/lid; other site
755178003313	ABC transporter signature motif; other site
755178003314	Walker B; other site
755178003315	D-loop; other site
755178003316	H-loop/switch region; other site
755178003317	Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086
755178003318	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
755178003319	UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237
755178003320	NAD(P) binding site [chemical binding]; other site
755178003321	homodimer interface [polypeptide binding]; other site
755178003322	substrate binding site [chemical binding]; other site
755178003323	active site
755178003324	Chain length determinant protein; Region: Wzz; pfam02706
755178003325	Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206
755178003326	capsular exopolysaccharide family; Region: eps_fam; TIGR01007
755178003327	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
755178003328	Phosphorylase superfamily; Region: PNP_UDP_1; cl00303
755178003329	Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334
755178003330	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
755178003331	NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076
755178003332	NAD(P) binding site [chemical binding]; other site
755178003333	Protein of unknown function (DUF3593); Region: DUF3593; pfam12159
755178003334	UreD urease accessory protein; Region: UreD; pfam01774
755178003335	CYTH-like Clostridium thermocellum TTM-like subgroup 1; Region: CYTH-like_CthTTM-like_1; cd07891
755178003336	putative active site [active]
755178003337	putative metal binding residues [ion binding]; other site
755178003338	signature motif; other site
755178003339	putative dimer interface [polypeptide binding]; other site
755178003340	putative phosphate binding site [ion binding]; other site
755178003341	Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805
755178003342	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
755178003343	Walker A motif; other site
755178003344	ATP binding site [chemical binding]; other site
755178003345	Walker B motif; other site
755178003346	Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459
755178003347	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
755178003348	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
755178003349	ribosomal protein L21; Region: rpl21; CHL00075
755178003350	50S ribosomal protein L27; Validated; Region: rpmA; PRK05435
755178003351	Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670
755178003352	Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432
755178003353	Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384
755178003354	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
755178003355	putative active site [active]
755178003356	ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346
755178003357	Clp amino terminal domain; Region: Clp_N; pfam02861
755178003358	Clp amino terminal domain; Region: Clp_N; pfam02861
755178003359	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
755178003360	Walker A motif; other site
755178003361	ATP binding site [chemical binding]; other site
755178003362	Walker B motif; other site
755178003363	arginine finger; other site
755178003364	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
755178003365	Walker A motif; other site
755178003366	ATP binding site [chemical binding]; other site
755178003367	Walker B motif; other site
755178003368	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
755178003369	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
755178003370	putative active site [active]
755178003371	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
755178003372	putative active site [active]
755178003373	catalytic residue [active]
755178003374	elongation factor Ts; Reviewed; Region: tsf; PRK12332
755178003375	UBA/TS-N domain; Region: UBA; pfam00627
755178003376	Elongation factor TS; Region: EF_TS; pfam00889
755178003377	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
755178003378	rRNA interaction site [nucleotide binding]; other site
755178003379	S8 interaction site; other site
755178003380	putative laminin-1 binding site; other site
755178003381	Protein of unknown function (DUF1822); Region: DUF1822; pfam08852
755178003382	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
755178003383	oligomerisation interface [polypeptide binding]; other site
755178003384	mobile loop; other site
755178003385	roof hairpin; other site
755178003386	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
755178003387	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
755178003388	ring oligomerisation interface [polypeptide binding]; other site
755178003389	ATP/Mg binding site [chemical binding]; other site
755178003390	stacking interactions; other site
755178003391	hinge regions; other site
755178003392	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
755178003393	catalytic core [active]
755178003394	Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139
755178003395	hypothetical protein; Reviewed; Region: PRK09588
755178003396	RecA/RadA recombinase [DNA replication, recombination, and repair]; Region: RecA; COG0468
755178003397	recA bacterial DNA recombination protein; Region: RecA; cl17211
755178003398	Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086
755178003399	hypothetical protein; Provisional; Region: PRK13560
755178003400	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
755178003401	putative active site [active]
755178003402	heme pocket [chemical binding]; other site
755178003403	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
755178003404	putative active site [active]
755178003405	heme pocket [chemical binding]; other site
755178003406	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
755178003407	putative active site [active]
755178003408	heme pocket [chemical binding]; other site
755178003409	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
755178003410	dimer interface [polypeptide binding]; other site
755178003411	phosphorylation site [posttranslational modification]
755178003412	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
755178003413	ATP binding site [chemical binding]; other site
755178003414	Mg2+ binding site [ion binding]; other site
755178003415	G-X-G motif; other site
755178003416	Response regulator receiver domain; Region: Response_reg; pfam00072
755178003417	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
755178003418	active site
755178003419	phosphorylation site [posttranslational modification]
755178003420	intermolecular recognition site; other site
755178003421	dimerization interface [polypeptide binding]; other site
755178003422	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
755178003423	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
755178003424	Probable transposase; Region: OrfB_IS605; pfam01385
755178003425	Transposase IS200 like; Region: Y1_Tnp; pfam01797
755178003426	CheB methylesterase; Region: CheB_methylest; pfam01339
755178003427	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
755178003428	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
755178003429	putative active site [active]
755178003430	heme pocket [chemical binding]; other site
755178003431	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
755178003432	putative active site [active]
755178003433	heme pocket [chemical binding]; other site
755178003434	PAS fold; Region: PAS_4; pfam08448
755178003435	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
755178003436	putative active site [active]
755178003437	heme pocket [chemical binding]; other site
755178003438	FO synthase subunit 2; Reviewed; Region: PRK07360
755178003439	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
755178003440	FeS/SAM binding site; other site
755178003441	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
755178003442	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
755178003443	active site
755178003444	phosphorylation site [posttranslational modification]
755178003445	intermolecular recognition site; other site
755178003446	dimerization interface [polypeptide binding]; other site
755178003447	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
755178003448	DNA binding residues [nucleotide binding]
755178003449	dimerization interface [polypeptide binding]; other site
755178003450	Domain of unknown function (DUF697); Region: DUF697; pfam05128
755178003451	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
755178003452	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
755178003453	dimer interface [polypeptide binding]; other site
755178003454	active site
755178003455	CoA binding pocket [chemical binding]; other site
755178003456	GAF domain; Region: GAF; pfam01590
755178003457	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
755178003458	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
755178003459	dimer interface [polypeptide binding]; other site
755178003460	phosphorylation site [posttranslational modification]
755178003461	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
755178003462	ATP binding site [chemical binding]; other site
755178003463	Mg2+ binding site [ion binding]; other site
755178003464	G-X-G motif; other site
755178003465	ATP-grasp domain; Region: ATP-grasp_2; pfam08442
755178003466	carotene isomerase; Region: carot_isom; TIGR02730
755178003467	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
755178003468	Predicted membrane protein [Function unknown]; Region: COG3431
755178003469	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
755178003470	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
755178003471	active site
755178003472	HIGH motif; other site
755178003473	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
755178003474	KMSKS motif; other site
755178003475	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
755178003476	ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl17272
755178003477	Protein of unknown function (DUF3816); Region: DUF3816; pfam12822
755178003478	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
755178003479	PAS fold; Region: PAS_3; pfam08447
755178003480	putative active site [active]
755178003481	heme pocket [chemical binding]; other site
755178003482	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
755178003483	dimer interface [polypeptide binding]; other site
755178003484	phosphorylation site [posttranslational modification]
755178003485	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
755178003486	ATP binding site [chemical binding]; other site
755178003487	Mg2+ binding site [ion binding]; other site
755178003488	G-X-G motif; other site
755178003489	Response regulator receiver domain; Region: Response_reg; pfam00072
755178003490	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
755178003491	active site
755178003492	phosphorylation site [posttranslational modification]
755178003493	intermolecular recognition site; other site
755178003494	dimerization interface [polypeptide binding]; other site
755178003495	Response regulator receiver domain; Region: Response_reg; pfam00072
755178003496	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
755178003497	active site
755178003498	phosphorylation site [posttranslational modification]
755178003499	intermolecular recognition site; other site
755178003500	dimerization interface [polypeptide binding]; other site
755178003501	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086
755178003502	ornithine carbamoyltransferase; Provisional; Region: PRK00779
755178003503	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
755178003504	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
755178003505	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
755178003506	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
755178003507	cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097
755178003508	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654
755178003509	cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219
755178003510	Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322
755178003511	cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219
755178003512	UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253
755178003513	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
755178003514	putative NAD(P) binding site [chemical binding]; other site
755178003515	active site
755178003516	putative substrate binding site [chemical binding]; other site
755178003517	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
755178003518	Family of unknown function (DUF490); Region: DUF490; pfam04357
755178003519	Uncharacterized ACR, COG1399; Region: DUF177; pfam02620
755178003520	Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847
755178003521	jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation.  The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414
755178003522	G-X-X-G motif; other site
755178003523	R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644
755178003524	RxxxH motif; other site
755178003525	putative inner membrane protein translocase component YidC; Provisional; Region: PRK02654
755178003526	membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592
755178003527	60Kd inner membrane protein; Region: 60KD_IMP; cl00489
755178003528	Bacterial PH domain; Region: DUF304; pfam03703
755178003529	Ribonuclease P; Region: Ribonuclease_P; cl00457
755178003530	50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399
755178003531	Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132
755178003532	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
755178003533	Multicopper oxidase; Region: Cu-oxidase; pfam00394
755178003534	Multicopper oxidase; Region: Cu-oxidase_2; pfam07731
755178003535	Plasmid encoded toxin Txe; Region: Plasmid_Txe; cl17389
755178003536	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604
755178003537	Predicted metal-binding protein [General function prediction only]; Region: COG3019
755178003538	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
755178003539	dimer interface [polypeptide binding]; other site
755178003540	phosphorylation site [posttranslational modification]
755178003541	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
755178003542	ATP binding site [chemical binding]; other site
755178003543	Mg2+ binding site [ion binding]; other site
755178003544	G-X-G motif; other site
755178003545	Protein of unknown function (DUF497); Region: DUF497; pfam04365
755178003546	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
755178003547	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
755178003548	active site
755178003549	phosphorylation site [posttranslational modification]
755178003550	intermolecular recognition site; other site
755178003551	dimerization interface [polypeptide binding]; other site
755178003552	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
755178003553	DNA binding site [nucleotide binding]
755178003554	Nitrogen fixation protein of unknown function; Region: Nif11; pfam07862
755178003555	rod shape-determining protein MreC; Provisional; Region: PRK13922
755178003556	Uncharacterized protein conserved in bacteria (DUF2133); Region: DUF2133; pfam09976
755178003557	basic leucine zipper DNA-binding and multimerization region of GCN4 and related proteins; Region: B_zip1; cl02576
755178003558	rod shape-determining protein MreC; Region: MreC; pfam04085
755178003559	ribonuclease Z; Region: RNase_Z; TIGR02651
755178003560	S23 ribosomal protein; Region: Ribosomal_S23p; pfam05635
755178003561	four helix bundle protein; Region: TIGR02436
755178003562	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
755178003563	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
755178003564	ligand binding site [chemical binding]; other site
755178003565	flexible hinge region; other site
755178003566	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
755178003567	Iron permease FTR1 family; Region: FTR1; cl00475
755178003568	Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152
755178003569	heterotetramer interface [polypeptide binding]; other site
755178003570	active site pocket [active]
755178003571	cleavage site
755178003572	Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681
755178003573	Zinc-dependent metalloprotease; MMP_like sub-family 1. A group of bacterial, archaeal, and fungal metalloproteinase domains similar to matrix metalloproteinases and astacin; Region: ZnMc_MMP_like_1; cd04279
755178003574	active site
755178003575	Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534
755178003576	homooctamer interface [polypeptide binding]; other site
755178003577	active site
755178003578	DinB family; Region: DinB; cl17821
755178003579	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
755178003580	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
755178003581	S-adenosylmethionine binding site [chemical binding]; other site
755178003582	ApaLI-like restriction endonuclease; Region: RE_ApaLI; pfam09499
755178003583	N-acetylmannosamine-6-phosphate 2-epimerase; Provisional; Region: PRK01130
755178003584	N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729
755178003585	putative active site cavity [active]
755178003586	TATA element modulatory factor 1 DNA binding; Region: TMF_DNA_bd; pfam12329
755178003587	Tubulin like; Region: Tubulin_2; pfam13809
755178003588	Protein of unknown function (DUF2281); Region: DUF2281; cl02355
755178003589	PIN domain of the VapC-like Sll0205 protein and homologs; Region: PIN_Sll0205; cd09872
755178003590	putative active site [active]
755178003591	Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026
755178003592	Protein kinase domain; Region: Pkinase; pfam00069
755178003593	Catalytic domain of Protein Kinases; Region: PKc; cd00180
755178003594	active site
755178003595	ATP binding site [chemical binding]; other site
755178003596	substrate binding site [chemical binding]; other site
755178003597	activation loop (A-loop); other site
755178003598	cobalt transport protein CbiM; Validated; Region: PRK06265
755178003599	Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891
755178003600	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
755178003601	fumarate hydratase; Reviewed; Region: fumC; PRK00485
755178003602	Class II fumarases; Region: Fumarase_classII; cd01362
755178003603	active site
755178003604	tetramer interface [polypeptide binding]; other site
755178003605	DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041
755178003606	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
755178003607	inhibitor-cofactor binding pocket; inhibition site
755178003608	pyridoxal 5'-phosphate binding site [chemical binding]; other site
755178003609	catalytic residue [active]
755178003610	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
755178003611	active site
755178003612	NTP binding site [chemical binding]; other site
755178003613	metal binding triad [ion binding]; metal-binding site
755178003614	antibiotic binding site [chemical binding]; other site
755178003615	WbqC-like protein family; Region: WbqC; pfam08889
755178003616	SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966
755178003617	PemK-like protein; Region: PemK; pfam02452
755178003618	XisI protein; Region: XisI; pfam08869
755178003619	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153
755178003620	Plasmid encoded toxin Txe; Region: Plasmid_Txe; cl17389
755178003621	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
755178003622	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
755178003623	active site
755178003624	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
755178003625	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: GT1_like_7; cd05844
755178003626	putative ADP-binding pocket [chemical binding]; other site
755178003627	HEPN domain; Region: HEPN; cl00824
755178003628	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
755178003629	active site
755178003630	NTP binding site [chemical binding]; other site
755178003631	metal binding triad [ion binding]; metal-binding site
755178003632	antibiotic binding site [chemical binding]; other site
755178003633	Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524
755178003634	Methyltransferase domain; Region: Methyltransf_31; pfam13847
755178003635	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
755178003636	S-adenosylmethionine binding site [chemical binding]; other site
755178003637	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
755178003638	binding surface
755178003639	Tetratricopeptide repeat; Region: TPR_16; pfam13432
755178003640	Methyltransferase domain; Region: Methyltransf_23; pfam13489
755178003641	Methyltransferase domain; Region: Methyltransf_11; pfam08241
755178003642	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
755178003643	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
755178003644	binding surface
755178003645	TPR motif; other site
755178003646	TPR repeat; Region: TPR_11; pfam13414
755178003647	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
755178003648	binding surface
755178003649	TPR motif; other site
755178003650	Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones]; Region: Spy; COG3914
755178003651	Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones]; Region: Spy; COG3914
755178003652	Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones]; Region: Spy; COG3914
755178003653	Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones]; Region: Spy; COG3914
755178003654	Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones]; Region: Spy; COG3914
755178003655	Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones]; Region: Spy; COG3914
755178003656	chromosomal replication initiation protein; Provisional; Region: PRK12422
755178003657	Type IV pilin PilA; Region: Pilin_PilA; pfam14245
755178003658	Type IV pilin PilA; Region: Pilin_PilA; pfam14245
755178003659	Domain of unknown function, appears to be related to a diverse group of endonucleases; Region: Endonuclease_DUF559; cd01038
755178003660	putative active site [active]
755178003661	Domain of unknown function DUF29; Region: DUF29; pfam01724
755178003662	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
755178003663	putative active site [active]
755178003664	Transmembrane protein; Region: Macoilin; pfam09726
755178003665	Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790
755178003666	cytochrome c oxidase, subunit II; Region: CoxB; TIGR02866
755178003667	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
755178003668	cytochrome c oxidase, subunit I; Region: CtaD_CoxA; TIGR02891
755178003669	Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115
755178003670	Heme-copper oxidase subunit III.  Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386
755178003671	Subunit I/III interface [polypeptide binding]; other site
755178003672	radical SAM family uncharacterized protein; Region: rSAM_fuse_unch; TIGR03960
755178003673	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
755178003674	FeS/SAM binding site; other site
755178003675	Uncharacterized protein conserved in bacteria (DUF2344); Region: DUF2344; cl02090
755178003676	radical SAM-linked protein; Region: sam_1_link_chp; TIGR03936
755178003677	Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217
755178003678	MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476
755178003679	MOSC domain; Region: MOSC; pfam03473
755178003680	Uncharacterized conserved protein (DUF2276); Region: DUF2276; pfam10040
755178003681	CRISPR/Cas system-associated RAMP superfamily protein Csm5; Region: Csm5_III-A; cl17437
755178003682	CRISPR/Cas system-associated RAMP superfamily protein Csm4; Region: Csm4_III-A; cl17438
755178003683	CRISPR/Cas system-associated RAMP superfamily protein Csm3; Region: Csm3_III-A; cd09684
755178003684	CRISPR/Cas system-associated protein Csm2; Region: Csm2_III-A; cd09647
755178003685	CRISPR/Cas system-associated protein Cas10; Region: Cas10_III; cd09680
755178003686	geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032
755178003687	bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14186
755178003688	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
755178003689	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
755178003690	homodimer interface [polypeptide binding]; other site
755178003691	NADP binding site [chemical binding]; other site
755178003692	substrate binding site [chemical binding]; other site
755178003693	putative FeS-containing Cyanobacterial-specific oxidoreductase; Region: cyano_FeS_chp; TIGR03279
755178003694	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
755178003695	Protein of unknown function (DUF512); Region: DUF512; pfam04459
755178003696	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
755178003697	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
755178003698	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
755178003699	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
755178003700	Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026
755178003701	DDE superfamily endonuclease; Region: DDE_3; pfam13358
755178003702	Homeodomain-like domain; Region: HTH_23; pfam13384
755178003703	Winged helix-turn helix; Region: HTH_29; pfam13551
755178003704	Winged helix-turn helix; Region: HTH_33; pfam13592
755178003705	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
755178003706	non-specific DNA binding site [nucleotide binding]; other site
755178003707	salt bridge; other site
755178003708	sequence-specific DNA binding site [nucleotide binding]; other site
755178003709	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
755178003710	methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657
755178003711	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231
755178003712	Predicted permeases [General function prediction only]; Region: COG0795
755178003713	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
755178003714	glutamate racemase; Provisional; Region: PRK00865
755178003715	AMIN domain; Region: AMIN; pfam11741
755178003716	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
755178003717	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
755178003718	active site
755178003719	metal binding site [ion binding]; metal-binding site
755178003720	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
755178003721	GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046
755178003722	putative C-terminal domain interface [polypeptide binding]; other site
755178003723	putative GSH binding site (G-site) [chemical binding]; other site
755178003724	putative dimer interface [polypeptide binding]; other site
755178003725	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776
755178003726	dimer interface [polypeptide binding]; other site
755178003727	N-terminal domain interface [polypeptide binding]; other site
755178003728	type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844
755178003729	The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089
755178003730	active site
755178003731	Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109
755178003732	substrate binding site [chemical binding]; other site
755178003733	metal binding site [ion binding]; metal-binding site
755178003734	Repair protein; Region: Repair_PSII; pfam04536
755178003735	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
755178003736	bacteriophage N4 adsorption protein B; Provisional; Region: nfrB; PRK15489
755178003737	chain length determinant protein tyrosine kinase EpsG; Region: EpsG; TIGR03029
755178003738	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
755178003739	BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids  leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557
755178003740	homodimer interface [polypeptide binding]; other site
755178003741	substrate-cofactor binding pocket; other site
755178003742	catalytic residue [active]
755178003743	Helix-Turn-Helix DNA binding domain of Heavy Metal Resistance transcription regulators; Region: HTH_HMRTR; cd04770
755178003744	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
755178003745	DNA binding residues [nucleotide binding]
755178003746	dimer interface [polypeptide binding]; other site
755178003747	metal binding site [ion binding]; metal-binding site
755178003748	Protein kinase domain; Region: Pkinase; pfam00069
755178003749	Catalytic domain of Protein Kinases; Region: PKc; cd00180
755178003750	active site
755178003751	ATP binding site [chemical binding]; other site
755178003752	substrate binding site [chemical binding]; other site
755178003753	activation loop (A-loop); other site
755178003754	Uncharacterized conserved protein [Function unknown]; Region: COG1262
755178003755	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
755178003756	Late competence development protein ComFB; Region: ComFB; pfam10719
755178003757	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
755178003758	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
755178003759	motif II; other site
755178003760	TRAP-type mannitol/chloroaromatic compound transport system, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT1; COG4663
755178003761	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441
755178003762	Predicted transcriptional regulator [Transcription]; Region: COG3682
755178003763	Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501
755178003764	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
755178003765	aminodeoxychorismate synthase, fungal clade; Region: PabB-fungal; TIGR01823
755178003766	glutamine binding [chemical binding]; other site
755178003767	catalytic triad [active]
755178003768	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
755178003769	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
755178003770	Domain of unknown function (DUF1995); Region: DUF1995; pfam09353
755178003771	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
755178003772	Domain of unknown function DUF21; Region: DUF21; pfam01595
755178003773	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
755178003774	Response regulator receiver domain; Region: Response_reg; pfam00072
755178003775	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
755178003776	active site
755178003777	phosphorylation site [posttranslational modification]
755178003778	intermolecular recognition site; other site
755178003779	dimerization interface [polypeptide binding]; other site
755178003780	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
755178003781	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
755178003782	metal binding site [ion binding]; metal-binding site
755178003783	active site
755178003784	I-site; other site
755178003785	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
755178003786	Predicted membrane protein [Function unknown]; Region: COG4083; cl15694
755178003787	hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466
755178003788	uncharacterized subgroup of aldehyde reductase and flavonoid reductase related proteins, extended (e) SDRs; Region: AR_FR_like_1_SDR_e; cd05228
755178003789	putative NADP binding site [chemical binding]; other site
755178003790	putative substrate binding site [chemical binding]; other site
755178003791	active site
755178003792	FAD binding domain; Region: FAD_binding_4; pfam01565
755178003793	glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387
755178003794	Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645
755178003795	active site
755178003796	SAM binding site [chemical binding]; other site
755178003797	homodimer interface [polypeptide binding]; other site
755178003798	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
755178003799	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
755178003800	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
755178003801	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
755178003802	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
755178003803	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
755178003804	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
755178003805	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4370
755178003806	conserved hypothetical protein; Region: TIGR03492
755178003807	septum formation inhibitor; Reviewed; Region: minC; PRK00513
755178003808	Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775
755178003809	phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385
755178003810	PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196
755178003811	dimerization interface [polypeptide binding]; other site
755178003812	putative ATP binding site [chemical binding]; other site
755178003813	Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797
755178003814	Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330
755178003815	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
755178003816	acetohydroxyacid synthase small subunit; Region: ilvH; CHL00100
755178003817	N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878
755178003818	putative valine binding site [chemical binding]; other site
755178003819	dimer interface [polypeptide binding]; other site
755178003820	Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369
755178003821	diaminobutyrate--2-oxoglutarate aminotransferase; Provisional; Region: PRK06938
755178003822	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
755178003823	inhibitor-cofactor binding pocket; inhibition site
755178003824	pyridoxal 5'-phosphate binding site [chemical binding]; other site
755178003825	catalytic residue [active]
755178003826	DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450
755178003827	pyridoxal 5'-phosphate binding site [chemical binding]; other site
755178003828	catalytic residue [active]
755178003829	Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264
755178003830	IucA / IucC family; Region: IucA_IucC; pfam04183
755178003831	Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276
755178003832	Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523
755178003833	Siderophore biosynthesis protein domain; Region: AlcB; smart01006
755178003834	Lysine/ornithine N-monooxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: IucD; COG3486
755178003835	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
755178003836	Major Facilitator Superfamily; Region: MFS_1; pfam07690
755178003837	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
755178003838	putative substrate translocation pore; other site
755178003839	Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264
755178003840	IucA / IucC family; Region: IucA_IucC; pfam04183
755178003841	Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276
755178003842	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
755178003843	iron-sulfur cluster biosynthesis transcriptional regulator SufR; Region: SufR_cyano; TIGR02702
755178003844	putative DNA binding site [nucleotide binding]; other site
755178003845	putative Zn2+ binding site [ion binding]; other site
755178003846	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
755178003847	Glycoprotease family; Region: Peptidase_M22; pfam00814
755178003848	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
755178003849	Cell cycle protein; Region: FTSW_RODA_SPOVE; pfam01098
755178003850	NAD(P)H-quinone oxidoreductase subunit F; Validated; Region: PRK07376
755178003851	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662
755178003852	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
755178003853	NADH-Ubiquinone oxidoreductase (complex I) subunit C-terminus; Region: Oxidored_q1_C; pfam01010
755178003854	Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196
755178003855	anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188
755178003856	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
755178003857	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
755178003858	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
755178003859	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
755178003860	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
755178003861	catalytic residue [active]
755178003862	L-asparaginase II; Region: Asparaginase_II; pfam06089
755178003863	allophycocyanin, beta subunit; Region: apcB; TIGR01337
755178003864	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
755178003865	C-terminal peptidase (prc); Region: prc; TIGR00225
755178003866	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
755178003867	protein binding site [polypeptide binding]; other site
755178003868	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
755178003869	Catalytic dyad [active]
755178003870	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5381
755178003871	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
755178003872	anti sigma factor interaction site; other site
755178003873	regulatory phosphorylation site [posttranslational modification]; other site
755178003874	Divergent PAP2 family; Region: DUF212; pfam02681
755178003875	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
755178003876	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
755178003877	substrate binding pocket [chemical binding]; other site
755178003878	chain length determination region; other site
755178003879	substrate-Mg2+ binding site; other site
755178003880	catalytic residues [active]
755178003881	aspartate-rich region 1; other site
755178003882	active site lid residues [active]
755178003883	aspartate-rich region 2; other site
755178003884	enolase; Provisional; Region: eno; PRK00077
755178003885	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
755178003886	dimer interface [polypeptide binding]; other site
755178003887	metal binding site [ion binding]; metal-binding site
755178003888	substrate binding pocket [chemical binding]; other site
755178003889	ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698
755178003890	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
755178003891	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
755178003892	Glycosyl transferase family 1; Region: Glyco_trans_1_3; pfam13528
755178003893	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
755178003894	FAD binding domain; Region: FAD_binding_4; pfam01565
755178003895	N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655
755178003896	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
755178003897	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
755178003898	putative active site [active]
755178003899	putative NTP binding site [chemical binding]; other site
755178003900	putative nucleic acid binding site [nucleotide binding]; other site
755178003901	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
755178003902	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
755178003903	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
755178003904	active site
755178003905	Protein of unknown function (DUF1810); Region: DUF1810; pfam08837
755178003906	Mo-dependent nitrogenase C-terminus; Region: Mo-nitro_C; pfam06967
755178003907	heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512
755178003908	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
755178003909	Soluble P-type ATPase [General function prediction only]; Region: COG4087
755178003910	Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285
755178003911	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
755178003912	NAD(P)H-quinone oxidoreductase subunit F; Validated; Region: PRK07390
755178003913	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662
755178003914	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
755178003915	NAD(P)H-quinone oxidoreductase subunit D4; Validated; Region: PRK06473
755178003916	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
755178003917	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
755178003918	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
755178003919	ring oligomerisation interface [polypeptide binding]; other site
755178003920	ATP/Mg binding site [chemical binding]; other site
755178003921	stacking interactions; other site
755178003922	hinge regions; other site
755178003923	Protein of unknown function (DUF497); Region: DUF497; pfam04365
755178003924	Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026
755178003925	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
755178003926	UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580
755178003927	Walker A motif; other site
755178003928	ATP binding site [chemical binding]; other site
755178003929	Family description; Region: UvrD_C_2; pfam13538
755178003930	Dock Homology Region 2, a GEF domain, of Dedicator of Cytokinesis proteins; Region: DHR2_DOCK; cl06123
755178003931	dimer interface [polypeptide binding]; other site
755178003932	Region in Clathrin and VPS; Region: Clathrin; pfam00637
755178003933	Mechanosensitive ion channel; Region: MS_channel; pfam00924
755178003934	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
755178003935	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
755178003936	ligand binding site [chemical binding]; other site
755178003937	flexible hinge region; other site
755178003938	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
755178003939	Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378
755178003940	substrate binding site [chemical binding]; other site
755178003941	oxyanion hole (OAH) forming residues; other site
755178003942	trimer interface [polypeptide binding]; other site
755178003943	dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286
755178003944	Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738
755178003945	quinone interaction residues [chemical binding]; other site
755178003946	active site
755178003947	catalytic residues [active]
755178003948	FMN binding site [chemical binding]; other site
755178003949	substrate binding site [chemical binding]; other site
755178003950	CobD/Cbib protein; Region: CobD_Cbib; pfam03186
755178003951	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
755178003952	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
755178003953	phosphopeptide binding site; other site
755178003954	Transglycosylase; Region: Transgly; pfam00912
755178003955	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
755178003956	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
755178003957	Etoposide-induced protein 2.4 (EI24); Region: EI24; cl01126
755178003958	Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439
755178003959	putative dimer interface [polypeptide binding]; other site
755178003960	active site pocket [active]
755178003961	putative cataytic base [active]
755178003962	Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687
755178003963	Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343
755178003964	hypothetical protein; Provisional; Region: PRK11770
755178003965	Domain of unknown function (DUF307); Region: DUF307; pfam03733
755178003966	Domain of unknown function (DUF307); Region: DUF307; pfam03733
755178003967	5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346
755178003968	Plastid and cyanobacterial ribosomal protein (PSRP-3 / Ycf65); Region: PSRP-3_Ycf65; cl04793
755178003969	prephenate dehydratase; Provisional; Region: PRK11898
755178003970	Prephenate dehydratase; Region: PDT; pfam00800
755178003971	C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905
755178003972	putative L-Phe binding site [chemical binding]; other site
755178003973	Protein of unknown function (DUF4079); Region: DUF4079; pfam13301
755178003974	Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758
755178003975	DNA protecting protein DprA; Region: dprA; TIGR00732
755178003976	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
755178003977	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
755178003978	Protein of unknown function (DUF2499); Region: DUF2499; pfam10693
755178003979	Taspase1_like domains; Taspase1 catalyzes the cleavage of the mix lineage leukemia (MLL) nuclear protein and transcription factor TFIIA. Taspase1 is a threonine aspartase, a member of the Ntn hydrolase superfamily and the type 2 asparaginase family. A...; Region: Taspase1_like; cd04514
755178003980	active site
755178003981	dimer interface [polypeptide binding]; other site
755178003982	catalytic nucleophile [active]
755178003983	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
755178003984	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
755178003985	MASE1; Region: MASE1; pfam05231
755178003986	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
755178003987	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
755178003988	dimer interface [polypeptide binding]; other site
755178003989	phosphorylation site [posttranslational modification]
755178003990	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
755178003991	ATP binding site [chemical binding]; other site
755178003992	Mg2+ binding site [ion binding]; other site
755178003993	G-X-G motif; other site
755178003994	Response regulator receiver domain; Region: Response_reg; pfam00072
755178003995	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
755178003996	active site
755178003997	phosphorylation site [posttranslational modification]
755178003998	intermolecular recognition site; other site
755178003999	dimerization interface [polypeptide binding]; other site
755178004000	Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722
755178004001	Helix-turn-helix domain; Region: HTH_25; pfam13413
755178004002	Domain of unknown function (DUF4115); Region: DUF4115; pfam13464
755178004003	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
755178004004	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
755178004005	RNA binding surface [nucleotide binding]; other site
755178004006	Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870
755178004007	active site
755178004008	Protein of unknown function (DUF2993); Region: DUF2993; pfam11209
755178004009	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
755178004010	NMT1-like family; Region: NMT1_2; pfam13379
755178004011	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
755178004012	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
755178004013	putative PBP binding loops; other site
755178004014	dimer interface [polypeptide binding]; other site
755178004015	ABC-ATPase subunit interface; other site
755178004016	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
755178004017	nitrate transport ATP-binding subunits C and D; Region: ntrCD; TIGR01184
755178004018	Walker A/P-loop; other site
755178004019	ATP binding site [chemical binding]; other site
755178004020	Q-loop/lid; other site
755178004021	ABC transporter signature motif; other site
755178004022	Walker B; other site
755178004023	D-loop; other site
755178004024	H-loop/switch region; other site
755178004025	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
755178004026	NMT1-like family; Region: NMT1_2; pfam13379
755178004027	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
755178004028	nitrate transport ATP-binding subunits C and D; Region: ntrCD; TIGR01184
755178004029	Walker A/P-loop; other site
755178004030	ATP binding site [chemical binding]; other site
755178004031	Q-loop/lid; other site
755178004032	ABC transporter signature motif; other site
755178004033	Walker B; other site
755178004034	D-loop; other site
755178004035	H-loop/switch region; other site
755178004036	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
755178004037	putative active site [active]
755178004038	heme pocket [chemical binding]; other site
755178004039	PAS domain S-box; Region: sensory_box; TIGR00229
755178004040	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
755178004041	putative active site [active]
755178004042	heme pocket [chemical binding]; other site
755178004043	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
755178004044	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
755178004045	dimer interface [polypeptide binding]; other site
755178004046	phosphorylation site [posttranslational modification]
755178004047	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
755178004048	ATP binding site [chemical binding]; other site
755178004049	Mg2+ binding site [ion binding]; other site
755178004050	G-X-G motif; other site
755178004051	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
755178004052	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
755178004053	active site
755178004054	phosphorylation site [posttranslational modification]
755178004055	intermolecular recognition site; other site
755178004056	dimerization interface [polypeptide binding]; other site
755178004057	PAS domain; Region: PAS; smart00091
755178004058	Response regulator receiver domain; Region: Response_reg; pfam00072
755178004059	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
755178004060	active site
755178004061	phosphorylation site [posttranslational modification]
755178004062	intermolecular recognition site; other site
755178004063	dimerization interface [polypeptide binding]; other site
755178004064	ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682
755178004065	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
755178004066	ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134
755178004067	ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220
755178004068	Walker A/P-loop; other site
755178004069	ATP binding site [chemical binding]; other site
755178004070	Q-loop/lid; other site
755178004071	ABC transporter signature motif; other site
755178004072	Walker B; other site
755178004073	D-loop; other site
755178004074	H-loop/switch region; other site
755178004075	Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686
755178004076	Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305
755178004077	hexamer interface [polypeptide binding]; other site
755178004078	ligand binding site [chemical binding]; other site
755178004079	putative active site [active]
755178004080	NAD(P) binding site [chemical binding]; other site
755178004081	NADH-quinone oxidoreductase cyanobacterial subunit N; Region: NdhN; pfam11909
755178004082	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
755178004083	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
755178004084	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
755178004085	Walker A/P-loop; other site
755178004086	ATP binding site [chemical binding]; other site
755178004087	Q-loop/lid; other site
755178004088	ABC transporter signature motif; other site
755178004089	Walker B; other site
755178004090	D-loop; other site
755178004091	H-loop/switch region; other site
755178004092	hypothetical protein; Provisional; Region: PRK10621
755178004093	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
755178004094	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
755178004095	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
755178004096	Metal binding protein ZntC.  These proteins are predicted to function as initial receptors in ABC transport of metal ions.  They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and ligand binding...; Region: ZntC; cd01018
755178004097	Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297
755178004098	putative metal binding residues [ion binding]; other site
755178004099	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883
755178004100	nudix motif; other site
755178004101	Uncharacterized conserved protein [General function prediction only]; Region: COG4111
755178004102	Protein kinase domain; Region: Pkinase; pfam00069
755178004103	Catalytic domain of Protein Kinases; Region: PKc; cd00180
755178004104	active site
755178004105	ATP binding site [chemical binding]; other site
755178004106	substrate binding site [chemical binding]; other site
755178004107	activation loop (A-loop); other site
755178004108	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
755178004109	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
755178004110	substrate binding pocket [chemical binding]; other site
755178004111	Ion channel; Region: Ion_trans_2; pfam07885
755178004112	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
755178004113	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
755178004114	membrane-bound complex binding site; other site
755178004115	hinge residues; other site
755178004116	Predicted nuclease of restriction endonuclease-like fold, RmuC family [General function prediction only]; Region: COG1322
755178004117	Domain of unknown function (DUF4175); Region: DUF4175; pfam13779
755178004118	Apolipoprotein A1/A4/E domain; Region: Apolipoprotein; pfam01442
755178004119	AAA domain; Region: AAA_13; pfam13166
755178004120	Cobalt transport protein; Region: CbiQ; cl00463
755178004121	hypothetical protein; Provisional; Region: PRK04323
755178004122	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
755178004123	homoserine dehydrogenase; Provisional; Region: PRK06349
755178004124	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
755178004125	ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881
755178004126	Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612
755178004127	Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628
755178004128	protoheme IX farnesyltransferase; Provisional; Region: PRK04375
755178004129	UbiA prenyltransferase family; Region: UbiA; pfam01040
755178004130	Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent  decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919
755178004131	tetramerization interface [polypeptide binding]; other site
755178004132	active site
755178004133	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
755178004134	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
755178004135	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
755178004136	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
755178004137	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
755178004138	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
755178004139	tocopherol O-methyltransferase; Region: PLN02244
755178004140	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
755178004141	S-adenosylmethionine binding site [chemical binding]; other site
755178004142	Domain of unknown function (DUF4359); Region: DUF4359; pfam14271
755178004143	Protein of unknown function (DUF2470); Region: DUF2470; pfam10615
755178004144	NurA nuclease; Region: NurA; smart00933
755178004145	cytochrome c biogenesis protein; Region: ccsA; CHL00045
755178004146	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
755178004147	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
755178004148	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
755178004149	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
755178004150	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
755178004151	substrate binding pocket [chemical binding]; other site
755178004152	membrane-bound complex binding site; other site
755178004153	hinge residues; other site
755178004154	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
755178004155	active site
755178004156	NTP binding site [chemical binding]; other site
755178004157	metal binding triad [ion binding]; metal-binding site
755178004158	antibiotic binding site [chemical binding]; other site
755178004159	Protein of unknown function DUF86; Region: DUF86; cl01031
755178004160	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
755178004161	primosomal protein N' Region: priA; TIGR00595
755178004162	ATP binding site [chemical binding]; other site
755178004163	putative Mg++ binding site [ion binding]; other site
755178004164	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
755178004165	nucleotide binding region [chemical binding]; other site
755178004166	ATP-binding site [chemical binding]; other site
755178004167	putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK07234
755178004168	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
755178004169	NADH dehydrogenase subunit J; Provisional; Region: PRK12494
755178004170	Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl16917
755178004171	NADH dehydrogenase subunit K; Region: ndhK; CHL00023
755178004172	NADH dehydrogenase subunit 3; Region: ndhC; CHL00022
755178004173	Transglycosylase; Region: Transgly; pfam00912
755178004174	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
755178004175	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
755178004176	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
755178004177	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
755178004178	GIY-YIG motif/motif A; other site
755178004179	active site
755178004180	catalytic site [active]
755178004181	putative DNA binding site [nucleotide binding]; other site
755178004182	metal binding site [ion binding]; metal-binding site
755178004183	UvrB/uvrC motif; Region: UVR; pfam02151
755178004184	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
755178004185	TPR repeat; Region: TPR_11; pfam13414
755178004186	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
755178004187	binding surface
755178004188	TPR motif; other site
755178004189	TPR repeat; Region: TPR_11; pfam13414
755178004190	Tetratricopeptide repeat; Region: TPR_1; pfam00515
755178004191	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
755178004192	Probable transposase; Region: OrfB_IS605; pfam01385
755178004193	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
755178004194	Transposase IS200 like; Region: Y1_Tnp; pfam01797
755178004195	pyruvate dehydrogenase E1 component alpha subunit; Reviewed; Region: odpA; CHL00149
755178004196	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
755178004197	tetramer interface [polypeptide binding]; other site
755178004198	TPP-binding site [chemical binding]; other site
755178004199	heterodimer interface [polypeptide binding]; other site
755178004200	phosphorylation loop region [posttranslational modification]
755178004201	Aerobic Cyclase System Fe-containing subunit (ACSF), ferritin-like diiron-binding domain; Region: ACSF; cd01047
755178004202	diiron binding motif [ion binding]; other site
755178004203	coproporphyrinogen III oxidase; Provisional; Region: PRK05330
755178004204	Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218
755178004205	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
755178004206	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
755178004207	Walker A/P-loop; other site
755178004208	ATP binding site [chemical binding]; other site
755178004209	Q-loop/lid; other site
755178004210	ABC transporter signature motif; other site
755178004211	Walker B; other site
755178004212	D-loop; other site
755178004213	H-loop/switch region; other site
755178004214	Response regulator receiver domain; Region: Response_reg; pfam00072
755178004215	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
755178004216	active site
755178004217	phosphorylation site [posttranslational modification]
755178004218	intermolecular recognition site; other site
755178004219	dimerization interface [polypeptide binding]; other site
755178004220	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
755178004221	NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956
755178004222	nucleotide binding pocket [chemical binding]; other site
755178004223	K-X-D-G motif; other site
755178004224	catalytic site [active]
755178004225	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
755178004226	NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119
755178004227	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
755178004228	Dimer interface [polypeptide binding]; other site
755178004229	BRCT sequence motif; other site
755178004230	Phosphoenolpyruvate:glucose-phosphotransferase regulator; Region: MtfA; cl01267
755178004231	Sensory domain found in DIguanylate Cyclases & Two-component systems; Region: DICT; cl01731
755178004232	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
755178004233	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
755178004234	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
755178004235	dimer interface [polypeptide binding]; other site
755178004236	phosphorylation site [posttranslational modification]
755178004237	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
755178004238	ATP binding site [chemical binding]; other site
755178004239	Mg2+ binding site [ion binding]; other site
755178004240	G-X-G motif; other site
755178004241	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
755178004242	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
755178004243	The C-terminal domain of a subfamily of Na+ /H+ antiporter existed in bacteria and archea . Na+/H+ exchange proteins eject protons from cells, effectively eliminating excess acid from actively metabolising cells. Na+ /H+ exchange activity is also crucial...; Region: Na_H_Antiporter_C; cd01988
755178004244	Ligand Binding Site [chemical binding]; other site
755178004245	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
755178004246	Ligand Binding Site [chemical binding]; other site
755178004247	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
755178004248	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
755178004249	phosphopeptide binding site; other site
755178004250	Domain of unknown function (DUF4327); Region: DUF4327; pfam14217
755178004251	plastocyanin; Provisional; Region: PRK02710
755178004252	Plastocyanin [Energy production and conversion]; Region: PetE; COG3794
755178004253	Tic22-like family; Region: Tic22; pfam04278
755178004254	proline aminopeptidase P II; Provisional; Region: PRK10879
755178004255	Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195
755178004256	Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087
755178004257	active site
755178004258	Predicted membrane protein [Function unknown]; Region: COG3463
755178004259	Predicted membrane protein (DUF2079); Region: DUF2079; pfam09852
755178004260	Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239
755178004261	Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239
755178004262	Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248
755178004263	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
755178004264	Predicted deacylase [General function prediction only]; Region: COG3608
755178004265	Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like; uncharacterized subgroup; Region: M14_ASTE_ASPA_like_1; cd06251
755178004266	putative active site [active]
755178004267	Zn binding site [ion binding]; other site
755178004268	elongation factor G; Reviewed; Region: PRK00007
755178004269	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
755178004270	G1 box; other site
755178004271	putative GEF interaction site [polypeptide binding]; other site
755178004272	GTP/Mg2+ binding site [chemical binding]; other site
755178004273	Switch I region; other site
755178004274	G2 box; other site
755178004275	G3 box; other site
755178004276	Switch II region; other site
755178004277	G4 box; other site
755178004278	G5 box; other site
755178004279	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
755178004280	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
755178004281	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
755178004282	ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917
755178004283	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
755178004284	generic binding surface II; other site
755178004285	ssDNA binding site; other site
755178004286	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
755178004287	ATP binding site [chemical binding]; other site
755178004288	putative Mg++ binding site [ion binding]; other site
755178004289	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
755178004290	nucleotide binding region [chemical binding]; other site
755178004291	ATP-binding site [chemical binding]; other site
755178004292	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
755178004293	C-3',4' desaturase CrtD; Region: desat_CrtD; TIGR02733
755178004294	phosphoribulokinase; Provisional; Region: PRK07429
755178004295	Phosphoribulokinase (PRK) is an enzyme involved in the Benson-Calvin cycle in chloroplasts or photosynthetic prokaryotes. This enzyme catalyzes the phosphorylation of D-ribulose 5-phosphate to form D-ribulose 1, 5-biphosphate, using ATP and NADPH...; Region: PRK; cd02026
755178004296	active site
755178004297	Predicted membrane protein [Function unknown]; Region: COG4803
755178004298	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876
755178004299	D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557
755178004300	Methyltransferase domain; Region: Methyltransf_31; pfam13847
755178004301	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
755178004302	S-adenosylmethionine binding site [chemical binding]; other site
755178004303	light-harvesting-like protein 3; Provisional; Region: PLN00014
755178004304	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
755178004305	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
755178004306	active site
755178004307	phosphorylation site [posttranslational modification]
755178004308	intermolecular recognition site; other site
755178004309	dimerization interface [polypeptide binding]; other site
755178004310	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
755178004311	DNA binding residues [nucleotide binding]
755178004312	dimerization interface [polypeptide binding]; other site
755178004313	alanine racemase; Reviewed; Region: alr; PRK00053
755178004314	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430
755178004315	active site
755178004316	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
755178004317	dimer interface [polypeptide binding]; other site
755178004318	substrate binding site [chemical binding]; other site
755178004319	catalytic residues [active]
755178004320	Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811
755178004321	Superfamily II RNA helicase [DNA replication, recombination, and repair]; Region: COG4581
755178004322	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
755178004323	ATP binding site [chemical binding]; other site
755178004324	putative Mg++ binding site [ion binding]; other site
755178004325	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
755178004326	nucleotide binding region [chemical binding]; other site
755178004327	ATP-binding site [chemical binding]; other site
755178004328	DSHCT (NUC185) domain; Region: DSHCT; pfam08148
755178004329	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_8; cd07817
755178004330	putative hydrophobic ligand binding site [chemical binding]; other site
755178004331	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
755178004332	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
755178004333	Walker A/P-loop; other site
755178004334	ATP binding site [chemical binding]; other site
755178004335	Q-loop/lid; other site
755178004336	ABC transporter signature motif; other site
755178004337	Walker B; other site
755178004338	D-loop; other site
755178004339	H-loop/switch region; other site
755178004340	S23 ribosomal protein; Region: Ribosomal_S23p; pfam05635
755178004341	four helix bundle protein; Region: TIGR02436
755178004342	Uncharacterized conserved protein [Function unknown]; Region: COG3937
755178004343	Electron transfer DM13; Region: DM13; pfam10517
755178004344	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
755178004345	substrate binding site; other site
755178004346	dimer interface; other site
755178004347	PPOX class probable FMN-dependent enzyme, alr4036 family; Region: PPOX_FMN_cyano; TIGR04026
755178004348	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxase_2; pfam12766
755178004349	Uncharacterized subfamily of  glycoside hydrolase family 57 (GH57); Region: GH57N_like_1; cd10798
755178004350	active site
755178004351	catalytic site [active]
755178004352	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
755178004353	Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234
755178004354	nucleotide binding site [chemical binding]; other site
755178004355	NEF interaction site [polypeptide binding]; other site
755178004356	SBD interface [polypeptide binding]; other site
755178004357	Cytochrome P450; Region: p450; pfam00067
755178004358	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
755178004359	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
755178004360	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_4; cd08500
755178004361	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
755178004362	Mechanosensitive ion channel; Region: MS_channel; pfam00924
755178004363	HAS barrel domain; Region: HAS-barrel; pfam09378
755178004364	Domain of Unknown Function (DUF928); Region: DUF928; pfam06051
755178004365	DEAD-like helicases superfamily; Region: DEXDc; smart00487
755178004366	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
755178004367	ATP binding site [chemical binding]; other site
755178004368	putative Mg++ binding site [ion binding]; other site
755178004369	Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513
755178004370	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
755178004371	nucleotide binding region [chemical binding]; other site
755178004372	ATP-binding site [chemical binding]; other site
755178004373	Predicted membrane protein [Function unknown]; Region: COG3174
755178004374	Domain of unknown function (DUF4010); Region: DUF4010; pfam13194
755178004375	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
755178004376	Mechanosensitive ion channel; Region: MS_channel; pfam00924
755178004377	Phycobilisome degradation protein nblA; Region: NblA; pfam04485
755178004378	DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14948
755178004379	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
755178004380	Walker A motif; other site
755178004381	ATP binding site [chemical binding]; other site
755178004382	Walker B motif; other site
755178004383	arginine finger; other site
755178004384	DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169
755178004385	GTPase YlqF; Reviewed; Region: rbgA; PRK09563
755178004386	Circularly permuted YlqF GTPase; Region: YlqF; cd01856
755178004387	GTP/Mg2+ binding site [chemical binding]; other site
755178004388	G4 box; other site
755178004389	G5 box; other site
755178004390	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
755178004391	G1 box; other site
755178004392	Switch I region; other site
755178004393	G2 box; other site
755178004394	G3 box; other site
755178004395	Switch II region; other site
755178004396	nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071
755178004397	Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165
755178004398	active site
755178004399	(T/H)XGH motif; other site
755178004400	phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885
755178004401	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
755178004402	Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071
755178004403	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
755178004404	7-cyano-7-deazaguanine reductase; Provisional; Region: PRK13258
755178004405	trigger factor; Provisional; Region: tig; PRK01490
755178004406	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
755178004407	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
755178004408	photochlorophyllide reductase subunit B; Region: chlB; CHL00076
755178004409	Pchlide_reductase_B: B protein of the NB protein complex of Protochlorophyllide (Pchlide)_reductase. Pchlide reductase catalyzes the reductive formation of chlorophyllide (chlide) from protochlorophyllide (pchlide) during biosynthesis of chlorophylls and...; Region: Pchlide_reductase_B; cd01981
755178004410	Proto-chlorophyllide reductase 57 kD subunit; Region: PCP_red; pfam08369
755178004411	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390
755178004412	2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449
755178004413	Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037
755178004414	dimer interface [polypeptide binding]; other site
755178004415	tetramer interface [polypeptide binding]; other site
755178004416	PYR/PP interface [polypeptide binding]; other site
755178004417	TPP binding site [chemical binding]; other site
755178004418	Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009
755178004419	TPP-binding site; other site
755178004420	Protein of unknown function (DUF2808); Region: DUF2808; pfam10989
755178004421	Predicted protein tyrosine phosphatase [General function prediction only]; Region: COG5350
755178004422	Predicted nuclease of the RNAse H fold, HicB family [General    function prediction only]; Region: COG1598
755178004423	Protein of unknown function (DUF497); Region: DUF497; pfam04365
755178004424	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
755178004425	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673
755178004426	motif 1; other site
755178004427	active site
755178004428	motif 2; other site
755178004429	motif 3; other site
755178004430	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
755178004431	DHHA1 domain; Region: DHHA1; pfam02272
755178004432	Transposase IS200 like; Region: Y1_Tnp; pfam01797
755178004433	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
755178004434	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
755178004435	Probable transposase; Region: OrfB_IS605; pfam01385
755178004436	RTX toxin acyltransferase family; Region: HlyC; cl01131
755178004437	dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; cl17405
755178004438	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
755178004439	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
755178004440	Walker A/P-loop; other site
755178004441	ATP binding site [chemical binding]; other site
755178004442	Q-loop/lid; other site
755178004443	ABC transporter signature motif; other site
755178004444	Walker B; other site
755178004445	D-loop; other site
755178004446	H-loop/switch region; other site
755178004447	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
755178004448	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
755178004449	Walker A/P-loop; other site
755178004450	ATP binding site [chemical binding]; other site
755178004451	Q-loop/lid; other site
755178004452	ABC transporter signature motif; other site
755178004453	Walker B; other site
755178004454	D-loop; other site
755178004455	H-loop/switch region; other site
755178004456	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
755178004457	Predicted ATPase of the ABC class; Region: ABC_ATPase; pfam09818
755178004458	S-adenosyl-l-methionine hydroxide adenosyltransferase; Region: SAM_adeno_trans; pfam01887
755178004459	S-layer homology domain; Region: SLH; pfam00395
755178004460	Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; cl00410
755178004461	GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089
755178004462	GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260
755178004463	NADP-binding site; other site
755178004464	homotetramer interface [polypeptide binding]; other site
755178004465	substrate binding site [chemical binding]; other site
755178004466	homodimer interface [polypeptide binding]; other site
755178004467	active site
755178004468	Domain of unknown function (DUF4114); Region: DUF4114; pfam13448
755178004469	GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239
755178004470	GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725
755178004471	NADP binding site [chemical binding]; other site
755178004472	active site
755178004473	putative substrate binding site [chemical binding]; other site
755178004474	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
755178004475	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
755178004476	FOG: WD40 repeat [General function prediction only]; Region: COG2319
755178004477	structural tetrad; other site
755178004478	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
755178004479	PAS fold; Region: PAS_3; pfam08447
755178004480	putative active site [active]
755178004481	heme pocket [chemical binding]; other site
755178004482	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
755178004483	GAF domain; Region: GAF; pfam01590
755178004484	PAS fold; Region: PAS_3; pfam08447
755178004485	Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086
755178004486	PAS domain S-box; Region: sensory_box; TIGR00229
755178004487	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
755178004488	putative active site [active]
755178004489	heme pocket [chemical binding]; other site
755178004490	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
755178004491	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
755178004492	metal binding site [ion binding]; metal-binding site
755178004493	active site
755178004494	I-site; other site
755178004495	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
755178004496	Bacterial SH3 domain; Region: SH3_3; cl17532
755178004497	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
755178004498	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
755178004499	active site
755178004500	metal binding site [ion binding]; metal-binding site
755178004501	Protein of unknown function (DUF552); Region: DUF552; cl00775
755178004502	pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880
755178004503	pyrroline-5-carboxylate reductase; Region: PLN02688
755178004504	Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231
755178004505	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
755178004506	hydroxyglutarate oxidase; Provisional; Region: PRK11728
755178004507	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
755178004508	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
755178004509	catalytic triad [active]
755178004510	PRC-barrel domain; Region: PRC; pfam05239
755178004511	Ycf27; Reviewed; Region: orf27; CHL00148
755178004512	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
755178004513	active site
755178004514	phosphorylation site [posttranslational modification]
755178004515	intermolecular recognition site; other site
755178004516	dimerization interface [polypeptide binding]; other site
755178004517	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
755178004518	DNA binding site [nucleotide binding]
755178004519	Pyruvate kinase [Carbohydrate transport and metabolism]; Region: PykF; COG0469
755178004520	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
755178004521	domain interfaces; other site
755178004522	active site
755178004523	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
755178004524	putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK07375
755178004525	putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK07234
755178004526	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
755178004527	Ribosomal protein S1 [Translation, ribosomal structure and biogenesis]; Region: RpsA; COG0539
755178004528	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
755178004529	RNA binding site [nucleotide binding]; other site
755178004530	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
755178004531	RNA binding site [nucleotide binding]; other site
755178004532	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
755178004533	RNA binding site [nucleotide binding]; other site
755178004534	photosystem II reaction center protein Z; Provisional; Region: psbZ; PRK02576
755178004535	lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209
755178004536	homopentamer interface [polypeptide binding]; other site
755178004537	active site
755178004538	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
755178004539	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
755178004540	dimer interface [polypeptide binding]; other site
755178004541	pyridoxal 5'-phosphate binding site [chemical binding]; other site
755178004542	catalytic residue [active]
755178004543	PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812
755178004544	putative active site [active]
755178004545	Protein of unknown function (DUF2281); Region: DUF2281; cl02355
755178004546	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
755178004547	TPR motif; other site
755178004548	binding surface
755178004549	Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661
755178004550	ABC1 family; Region: ABC1; pfam03109
755178004551	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
755178004552	active site
755178004553	ATP binding site [chemical binding]; other site
755178004554	S-layer homology domain; Region: SLH; pfam00395
755178004555	Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966
755178004556	tRNA synthetases class I (I, L, M and V); Region: tRNA-synt_1; pfam00133
755178004557	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
755178004558	active site
755178004559	HIGH motif; other site
755178004560	nucleotide binding site [chemical binding]; other site
755178004561	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
755178004562	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
755178004563	active site
755178004564	KMSKS motif; other site
755178004565	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
755178004566	tRNA binding surface [nucleotide binding]; other site
755178004567	anticodon binding site; other site
755178004568	Anticodon-binding domain of tRNA; Region: Anticodon_1; pfam08264
755178004569	Domain of unknown function (DUF4308); Region: DUF4308; pfam14159
755178004570	Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458
755178004571	NAD(P)H-quinone oxidoreductase subunit 4; Provisional; Region: PRK12561
755178004572	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
755178004573	quinolinate synthetase; Provisional; Region: PRK09375
755178004574	Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100
755178004575	Aluminium resistance protein; Region: Alum_res; pfam06838
755178004576	hypothetical protein; Reviewed; Region: PRK00024
755178004577	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
755178004578	MPN+ (JAMM) motif; other site
755178004579	Zinc-binding site [ion binding]; other site
755178004580	penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423
755178004581	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
755178004582	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
755178004583	phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144
755178004584	active site
755178004585	metal binding site [ion binding]; metal-binding site
755178004586	MiaE tRNA-modifying nonheme diiron monooxygenase, ferritin-like diiron-binding domain; Region: MiaE; cd07910
755178004587	active site
755178004588	dinuclear metal binding site [ion binding]; other site
755178004589	dimerization interface [polypeptide binding]; other site
755178004590	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
755178004591	Catalytic domain of Protein Kinases; Region: PKc; cd00180
755178004592	active site
755178004593	ATP binding site [chemical binding]; other site
755178004594	substrate binding site [chemical binding]; other site
755178004595	activation loop (A-loop); other site
755178004596	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
755178004597	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
755178004598	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
755178004599	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
755178004600	Domain of unknown function DUF20; Region: UPF0118; pfam01594
755178004601	Integral membrane protein TerC family; Region: TerC; cl10468
755178004602	Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732
755178004603	DNA repair protein RadA; Provisional; Region: PRK11823
755178004604	Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121
755178004605	Walker A motif/ATP binding site; other site
755178004606	ATP binding site [chemical binding]; other site
755178004607	Walker B motif; other site
755178004608	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
755178004609	PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392
755178004610	active site
755178004611	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
755178004612	Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016
755178004613	arginine-tRNA ligase; Region: PLN02286
755178004614	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
755178004615	active site
755178004616	HIGH motif; other site
755178004617	KMSK motif region; other site
755178004618	Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956
755178004619	tRNA binding surface [nucleotide binding]; other site
755178004620	anticodon binding site; other site
755178004621	DNA gyrase subunit A; Validated; Region: PRK05560
755178004622	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
755178004623	CAP-like domain; other site
755178004624	active site
755178004625	primary dimer interface [polypeptide binding]; other site
755178004626	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
755178004627	Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578
755178004628	NlpE N-terminal domain; Region: NlpE; pfam04170
755178004629	META domain; Region: META; pfam03724
755178004630	Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823
755178004631	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
755178004632	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
755178004633	Ycf66 protein N-terminus; Region: Ycf66_N; pfam07444
755178004634	Photosystem II reaction centre X protein (PsbX); Region: PsbX; pfam06596
755178004635	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
755178004636	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
755178004637	NAD(P) binding site [chemical binding]; other site
755178004638	homotetramer interface [polypeptide binding]; other site
755178004639	homodimer interface [polypeptide binding]; other site
755178004640	active site
755178004641	Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312
755178004642	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
755178004643	catalytic core [active]
755178004644	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
755178004645	catalytic core [active]
755178004646	ribosomal protein S20; Region: rps20; CHL00102
755178004647	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
755178004648	Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099
755178004649	active site
755178004650	DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405
755178004651	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
755178004652	RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561
755178004653	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
755178004654	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
755178004655	RPB1 interaction site [polypeptide binding]; other site
755178004656	RPB12 interaction site [polypeptide binding]; other site
755178004657	RPB10 interaction site [polypeptide binding]; other site
755178004658	RPB11 interaction site [polypeptide binding]; other site
755178004659	RPB3 interaction site [polypeptide binding]; other site
755178004660	RPB12 interaction site [polypeptide binding]; other site
755178004661	DNA-directed RNA polymerase subunit beta'; Provisional; Region: rpoC2; PRK02597
755178004662	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
755178004663	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
755178004664	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
755178004665	Rpb1 - Rpb6 interaction site [polypeptide binding]; other site
755178004666	Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_HprK; cl00270
755178004667	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
755178004668	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
755178004669	DNA binding site [nucleotide binding]
755178004670	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
755178004671	tellurite resistance protein terB; Region: terB; cd07176
755178004672	putative metal binding site [ion binding]; other site
755178004673	catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061
755178004674	N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649
755178004675	dimer interface [polypeptide binding]; other site
755178004676	active site
755178004677	heme binding site [chemical binding]; other site
755178004678	C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200
755178004679	Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195
755178004680	active site
755178004681	dimer interface [polypeptide binding]; other site
755178004682	metal binding site [ion binding]; metal-binding site
755178004683	Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446
755178004684	proton extrusion protein PcxA; Provisional; Region: PRK02507
755178004685	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
755178004686	23S rRNA binding site [nucleotide binding]; other site
755178004687	L21 binding site [polypeptide binding]; other site
755178004688	L13 binding site [polypeptide binding]; other site
755178004689	50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172
755178004690	extracellular substrate-binding orphan protein, GRRM family; Region: orph_peri_GRRM; TIGR04262
755178004691	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
755178004692	substrate binding pocket [chemical binding]; other site
755178004693	membrane-bound complex binding site; other site
755178004694	hinge residues; other site
755178004695	rSAM-associated Gly-rich repeat protein; Region: Cyano_gly_rpt; TIGR04260
755178004696	radical SAM/SPASM domain protein, GRRM system; Region: rSAM_GlyRichRpt; TIGR04261
755178004697	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
755178004698	FeS/SAM binding site; other site
755178004699	Domain of unknown function (DUF4008); Region: DUF4008; cl14869
755178004700	Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114
755178004701	Heat shock protein 33 (Hsp33):  Cytosolic protein that acts as a molecular chaperone under oxidative conditions.  In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498
755178004702	dimerization interface [polypeptide binding]; other site
755178004703	domain crossover interface; other site
755178004704	redox-dependent activation switch; other site
755178004705	Thf1-like protein; Reviewed; Region: PRK13266
755178004706	photosystem II biogenesis protein Psp29; Region: PS_II_psb29; TIGR03060
755178004707	seryl-tRNA synthetase; Provisional; Region: PRK05431
755178004708	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
755178004709	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770
755178004710	dimer interface [polypeptide binding]; other site
755178004711	active site
755178004712	motif 1; other site
755178004713	motif 2; other site
755178004714	motif 3; other site
755178004715	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
755178004716	active site
755178004717	dimerization interface [polypeptide binding]; other site
755178004718	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
755178004719	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
755178004720	nucleotide binding site [chemical binding]; other site
755178004721	TPR repeat; Region: TPR_11; pfam13414
755178004722	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
755178004723	binding surface
755178004724	TPR motif; other site
755178004725	TPR repeat; Region: TPR_11; pfam13414
755178004726	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
755178004727	TPR motif; other site
755178004728	binding surface
755178004729	Type II restriction enzyme, methylase subunits [Defense mechanisms]; Region: COG1002
755178004730	Methyltransferase domain; Region: Methyltransf_26; pfam13659
755178004731	hypothetical protein; Provisional; Region: PRK02237
755178004732	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
755178004733	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
755178004734	Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177
755178004735	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
755178004736	minor groove reading motif; other site
755178004737	helix-hairpin-helix signature motif; other site
755178004738	substrate binding pocket [chemical binding]; other site
755178004739	active site
755178004740	iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525
755178004741	Uncharacterized conserved protein [Function unknown]; Region: COG1543
755178004742	N-terminal catalytic domain of  alpha-amylase ( AmyC ) and similar proteins; Region: GH57N_AmyC_like; cd10792
755178004743	active site
755178004744	substrate binding site [chemical binding]; other site
755178004745	catalytic site [active]
755178004746	Domain of unknown function (DUF1957); Region: DUF1957; pfam09210
755178004747	multifunctional aminopeptidase A; Provisional; Region: PRK00913
755178004748	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
755178004749	interface (dimer of trimers) [polypeptide binding]; other site
755178004750	Substrate-binding/catalytic site; other site
755178004751	Zn-binding sites [ion binding]; other site
755178004752	Protein of unknown function (DUF2839); Region: DUF2839; pfam10999
755178004753	Protein of unknown function (DUF2854); Region: DUF2854; pfam11016
755178004754	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
755178004755	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
755178004756	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
755178004757	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
755178004758	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
755178004759	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
755178004760	putative active site [active]
755178004761	heme pocket [chemical binding]; other site
755178004762	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
755178004763	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
755178004764	putative active site [active]
755178004765	heme pocket [chemical binding]; other site
755178004766	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
755178004767	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
755178004768	putative active site [active]
755178004769	heme pocket [chemical binding]; other site
755178004770	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
755178004771	putative active site [active]
755178004772	heme pocket [chemical binding]; other site
755178004773	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
755178004774	Histidine kinase; Region: HisKA_2; pfam07568
755178004775	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
755178004776	ATP binding site [chemical binding]; other site
755178004777	Mg2+ binding site [ion binding]; other site
755178004778	G-X-G motif; other site
755178004779	Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110
755178004780	Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349
755178004781	trimer interface [polypeptide binding]; other site
755178004782	active site
755178004783	substrate binding site [chemical binding]; other site
755178004784	CoA binding site [chemical binding]; other site
755178004785	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
755178004786	active site
755178004787	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
755178004788	AAA domain; Region: AAA_21; pfam13304
755178004789	Walker A/P-loop; other site
755178004790	ATP binding site [chemical binding]; other site
755178004791	acetyl-CoA synthetase; Provisional; Region: PRK00174
755178004792	Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966
755178004793	active site
755178004794	CoA binding site [chemical binding]; other site
755178004795	acyl-activating enzyme (AAE) consensus motif; other site
755178004796	AMP binding site [chemical binding]; other site
755178004797	acetate binding site [chemical binding]; other site
755178004798	ATP adenylyltransferase (5',5'''-P-1,P-4-tetraphosphate phosphorylase II) [Nucleotide transport and metabolism]; Region: APA2; COG4360
755178004799	ATP adenylyltransferase; Region: ATP_transf; pfam09830
755178004800	Protein of unknown function (DUF1997); Region: DUF1997; pfam09366
755178004801	Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041
755178004802	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
755178004803	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
755178004804	hopene-associated glycosyltransferase HpnB; Region: HpnB; TIGR03469
755178004805	CESA_like is  the cellulose synthase superfamily; Region: CESA_like; cd06423
755178004806	DXD motif; other site
755178004807	Uncharacterized conserved protein [Function unknown]; Region: COG0062
755178004808	B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171
755178004809	putative substrate binding site [chemical binding]; other site
755178004810	putative ATP binding site [chemical binding]; other site
755178004811	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
755178004812	CAAX protease self-immunity; Region: Abi; pfam02517
755178004813	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
755178004814	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
755178004815	photosystem II reaction center protein M; Provisional; Region: psbM; PRK04989
755178004816	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
755178004817	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
755178004818	motif II; other site
755178004819	D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581
755178004820	Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173
755178004821	ligand binding site [chemical binding]; other site
755178004822	NAD binding site [chemical binding]; other site
755178004823	dimerization interface [polypeptide binding]; other site
755178004824	catalytic site [active]
755178004825	C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902
755178004826	putative L-serine binding site [chemical binding]; other site
755178004827	ribosomal protein L11 methyltransferase; Reviewed; Region: prmA; PRK00517
755178004828	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
755178004829	S-adenosylmethionine binding site [chemical binding]; other site
755178004830	CHAD domain; Region: CHAD; cl10506
755178004831	shikimate kinase; Reviewed; Region: aroK; PRK00131
755178004832	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
755178004833	ADP binding site [chemical binding]; other site
755178004834	magnesium binding site [ion binding]; other site
755178004835	putative shikimate binding site; other site
755178004836	YGGT family; Region: YGGT; pfam02325
755178004837	haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702
755178004838	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
755178004839	motif II; other site
755178004840	NADH dehydrogenase subunit 4L; Region: ndhE; CHL00015
755178004841	NADH dehydrogenase subunit 6; Region: ndhG; CHL00016
755178004842	NADH dehydrogenase subunit J; Provisional; Region: PRK06433
755178004843	NADH-plastoquinone oxidoreductase subunit I protein; Region: ndhI; TIGR00403
755178004844	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
755178004845	ferrochelatase; Reviewed; Region: hemH; PRK00035
755178004846	Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411
755178004847	C-terminal domain interface [polypeptide binding]; other site
755178004848	active site
755178004849	Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419
755178004850	active site
755178004851	N-terminal domain interface [polypeptide binding]; other site
755178004852	Chlorophyll A-B binding protein; Region: Chloroa_b-bind; pfam00504
755178004853	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467
755178004854	iron-sulfur cluster [ion binding]; other site
755178004855	[2Fe-2S] cluster binding site [ion binding]; other site
755178004856	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153
755178004857	Plasmid encoded toxin Txe; Region: Plasmid_Txe; pfam06769
755178004858	Maf-like protein; Region: Maf; pfam02545
755178004859	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
755178004860	active site
755178004861	dimer interface [polypeptide binding]; other site
755178004862	hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062
755178004863	hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075
755178004864	Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N; pfam00033
755178004865	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
755178004866	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
755178004867	NAD(P) binding site [chemical binding]; other site
755178004868	active site
755178004869	hypothetical protein; Provisional; Region: PRK01617
755178004870	SEC-C motif; Region: SEC-C; pfam02810
755178004871	bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238
755178004872	Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576
755178004873	substrate binding site [chemical binding]; other site
755178004874	Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581
755178004875	substrate binding site [chemical binding]; other site
755178004876	ligand binding site [chemical binding]; other site
755178004877	Transposase IS200 like; Region: Y1_Tnp; cl00848
755178004878	GUN4-like; Region: GUN4; pfam05419
755178004879	Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206
755178004880	capsular exopolysaccharide family; Region: eps_fam; TIGR01007
755178004881	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
755178004882	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
755178004883	polysaccharide export protein EpsE; Region: EpsE; TIGR03028
755178004884	SLBB domain; Region: SLBB; pfam10531
755178004885	SLBB domain; Region: SLBB; pfam10531
755178004886	tryptophan-rich conserved hypothetical protein; Region: TIGR02450
755178004887	squalene-hopene cyclase; Region: hopene_cyclase; TIGR01507
755178004888	Squalene cyclase (SQCY) domain subgroup 1; found in class II terpene cyclases that have an alpha 6 - alpha 6 barrel fold. Squalene cyclase (SQCY)  and 2,3-oxidosqualene cyclase (OSQCY) are integral membrane proteins that catalyze a cationic cyclization...; Region: SQCY_1; cd02892
755178004889	Active site cavity [active]
755178004890	catalytic acid [active]
755178004891	Domain of unknown function (DUF4253); Region: DUF4253; pfam14062
755178004892	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
755178004893	binding surface
755178004894	Tetratricopeptide repeat; Region: TPR_16; pfam13432
755178004895	TPR motif; other site
755178004896	TPR repeat; Region: TPR_11; pfam13414
755178004897	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
755178004898	binding surface
755178004899	TPR motif; other site
755178004900	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
755178004901	binding surface
755178004902	TPR motif; other site
755178004903	Protein of unknown function (DUF563); Region: DUF563; pfam04577
755178004904	Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004
755178004905	Prp18 domain; Region: Prp18; pfam02840
755178004906	Thymidylate synthase complementing protein; Region: Thy1; cl03630
755178004907	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in a group of uncharacterized proteins from bacteria and archaea; Region: NTP-PPase_u4; cd11541
755178004908	putative metal binding site [ion binding]; other site
755178004909	cell division protein FtsZ; Validated; Region: PRK09330
755178004910	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
755178004911	nucleotide binding site [chemical binding]; other site
755178004912	SulA interaction site; other site
755178004913	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
755178004914	TPR motif; other site
755178004915	binding surface
755178004916	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4735
755178004917	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
755178004918	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
755178004919	catalytic loop [active]
755178004920	iron binding site [ion binding]; other site
755178004921	apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302
755178004922	Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571
755178004923	putative active site [active]
755178004924	catalytic triad [active]
755178004925	putative dimer interface [polypeptide binding]; other site
755178004926	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
755178004927	dimerization interface [polypeptide binding]; other site
755178004928	putative DNA binding site [nucleotide binding]; other site
755178004929	putative Zn2+ binding site [ion binding]; other site
755178004930	ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803
755178004931	Metal binding protein PsaA.  These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species.  They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137
755178004932	metal binding site [ion binding]; metal-binding site
755178004933	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
755178004934	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
755178004935	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
755178004936	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
755178004937	ABC-ATPase subunit  interface; other site
755178004938	dimer interface [polypeptide binding]; other site
755178004939	putative PBP binding regions; other site
755178004940	Protein of unknown function (DUF3326); Region: DUF3326; pfam11805
755178004941	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1649
755178004942	Uncharacterized BCR, COG1649; Region: DUF187; pfam02638
755178004943	Clp protease ATP binding subunit; Region: clpC; CHL00095
755178004944	Clp amino terminal domain; Region: Clp_N; pfam02861
755178004945	Clp amino terminal domain; Region: Clp_N; pfam02861
755178004946	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
755178004947	Walker A motif; other site
755178004948	ATP binding site [chemical binding]; other site
755178004949	Walker B motif; other site
755178004950	arginine finger; other site
755178004951	UvrB/uvrC motif; Region: UVR; pfam02151
755178004952	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
755178004953	Walker A motif; other site
755178004954	ATP binding site [chemical binding]; other site
755178004955	Walker B motif; other site
755178004956	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
755178004957	Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836
755178004958	GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509
755178004959	Substrate binding site; other site
755178004960	Cupin domain; Region: Cupin_2; cl17218
755178004961	Transcriptional regulator [Transcription]; Region: LytR; COG1316
755178004962	LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399
755178004963	Methyltransferase domain; Region: Methyltransf_23; pfam13489
755178004964	CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575
755178004965	phosphatidate cytidylyltransferase; Region: PLN02953
755178004966	2-isopropylmalate synthase; Validated; Region: PRK00915
755178004967	2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940
755178004968	active site
755178004969	catalytic residues [active]
755178004970	metal binding site [ion binding]; metal-binding site
755178004971	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502
755178004972	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
755178004973	active site
755178004974	ribulose/triose binding site [chemical binding]; other site
755178004975	phosphate binding site [ion binding]; other site
755178004976	substrate (anthranilate) binding pocket [chemical binding]; other site
755178004977	product (indole) binding pocket [chemical binding]; other site
755178004978	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_3; cd07820
755178004979	putative hydrophobic ligand binding site [chemical binding]; other site
755178004980	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
755178004981	binding surface
755178004982	TPR motif; other site
755178004983	TPR repeat; Region: TPR_11; pfam13414
755178004984	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
755178004985	binding surface
755178004986	TPR motif; other site
755178004987	TPR repeat; Region: TPR_11; pfam13414
755178004988	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
755178004989	TPR repeat; Region: TPR_11; pfam13414
755178004990	binding surface
755178004991	TPR motif; other site
755178004992	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
755178004993	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
755178004994	Probable transposase; Region: OrfB_IS605; pfam01385
755178004995	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cl00047
755178004996	polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824
755178004997	Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363
755178004998	RNase E interface [polypeptide binding]; other site
755178004999	trimer interface [polypeptide binding]; other site
755178005000	Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726
755178005001	Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364
755178005002	RNase E interface [polypeptide binding]; other site
755178005003	trimer interface [polypeptide binding]; other site
755178005004	active site
755178005005	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
755178005006	putative nucleic acid binding region [nucleotide binding]; other site
755178005007	G-X-X-G motif; other site
755178005008	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
755178005009	RNA binding site [nucleotide binding]; other site
755178005010	domain interface; other site
755178005011	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
755178005012	putative active site [active]
755178005013	tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192
755178005014	tRNA:m(5)U-54 methyltransferase; Region: gid_trmFO; TIGR00137
755178005015	tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335
755178005016	GidA associated domain 3; Region: GIDA_assoc_3; pfam13932
755178005017	Fe-S oxidoreductase [Energy production and conversion]; Region: COG1032
755178005018	B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068
755178005019	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
755178005020	FeS/SAM binding site; other site
755178005021	Domain of unknown function (DUF4070); Region: DUF4070; pfam13282
755178005022	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807
755178005023	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231
755178005024	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657
755178005025	dinuclear metal binding motif [ion binding]; other site
755178005026	Protein of unknown function (DUF4079); Region: DUF4079; pfam13301
755178005027	spermine synthase; Region: PLN02823
755178005028	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
755178005029	S-adenosylmethionine binding site [chemical binding]; other site
755178005030	putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737
755178005031	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
755178005032	FMN binding site [chemical binding]; other site
755178005033	active site
755178005034	catalytic residues [active]
755178005035	substrate binding site [chemical binding]; other site
755178005036	2TM domain; Region: 2TM; pfam13239
755178005037	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
755178005038	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
755178005039	dimerization interface [polypeptide binding]; other site
755178005040	DNA binding residues [nucleotide binding]
755178005041	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
755178005042	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
755178005043	active site
755178005044	phosphorylation site [posttranslational modification]
755178005045	intermolecular recognition site; other site
755178005046	dimerization interface [polypeptide binding]; other site
755178005047	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
755178005048	DNA binding site [nucleotide binding]
755178005049	Ferredoxin thioredoxin reductase variable alpha chain; Region: FeThRed_A; pfam02941
755178005050	Domain of unknown function (DUF389); Region: DUF389; pfam04087
755178005051	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
755178005052	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
755178005053	ligand binding site [chemical binding]; other site
755178005054	flexible hinge region; other site
755178005055	acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180
755178005056	propionate/acetate kinase; Provisional; Region: PRK12379
755178005057	DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061
755178005058	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
755178005059	ATP binding site [chemical binding]; other site
755178005060	putative Mg++ binding site [ion binding]; other site
755178005061	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
755178005062	nucleotide binding region [chemical binding]; other site
755178005063	ATP-binding site [chemical binding]; other site
755178005064	Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cl17280
755178005065	active site
755178005066	putative DNA-binding cleft [nucleotide binding]; other site
755178005067	dimer interface [polypeptide binding]; other site
755178005068	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
755178005069	phosphate:H+ symporter; Region: 2A0109; TIGR00887
755178005070	putative substrate translocation pore; other site
755178005071	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
755178005072	sulfate adenylyltransferase; Reviewed; Region: sat; PRK04149
755178005073	ATP-sulfurylase; Region: ATPS; cd00517
755178005074	active site
755178005075	HXXH motif; other site
755178005076	flexible loop; other site
755178005077	cobalamin biosynthesis protein CobW; Region: CobW; TIGR02475
755178005078	CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492
755178005079	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683
755178005080	DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095
755178005081	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
755178005082	ATP binding site [chemical binding]; other site
755178005083	Mg2+ binding site [ion binding]; other site
755178005084	G-X-G motif; other site
755178005085	MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782
755178005086	ATP binding site [chemical binding]; other site
755178005087	MutL C terminal dimerisation domain; Region: MutL_C; pfam08676
755178005088	Dihaem cytochrome c; Region: DHC; pfam09626
755178005089	MoxR-like ATPases [General function prediction only]; Region: COG0714
755178005090	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
755178005091	Walker A motif; other site
755178005092	ATP binding site [chemical binding]; other site
755178005093	Walker B motif; other site
755178005094	arginine finger; other site
755178005095	sucrose-6-phosphate hydrolase; Region: scrB_fam; TIGR01322
755178005096	ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033
755178005097	CAAX protease self-immunity; Region: Abi; pfam02517
755178005098	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
755178005099	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
755178005100	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
755178005101	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
755178005102	NHLM bacteriocin system ABC transporter, ATP-binding protein; Region: NHLM_micro_ABC2; TIGR03797
755178005103	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
755178005104	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
755178005105	Walker A/P-loop; other site
755178005106	ATP binding site [chemical binding]; other site
755178005107	Q-loop/lid; other site
755178005108	ABC transporter signature motif; other site
755178005109	Walker B; other site
755178005110	D-loop; other site
755178005111	H-loop/switch region; other site
755178005112	NHLM bacteriocin system ABC transporter, peptidase/ATP-binding protein; Region: NHLM_micro_ABC1; TIGR03796
755178005113	Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296
755178005114	putative active site [active]
755178005115	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
755178005116	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
755178005117	Walker A/P-loop; other site
755178005118	ATP binding site [chemical binding]; other site
755178005119	Q-loop/lid; other site
755178005120	ABC transporter signature motif; other site
755178005121	Walker B; other site
755178005122	D-loop; other site
755178005123	H-loop/switch region; other site
755178005124	NHLM bacteriocin system secretion protein; Region: NHLM_micro_HlyD; TIGR03794
755178005125	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
755178005126	HlyD family secretion protein; Region: HlyD_3; pfam13437
755178005127	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
755178005128	bacteriocin-type transport-associated protein; Region: cyc_nuc_ocin; TIGR03896
755178005129	ligand binding site [chemical binding]; other site
755178005130	flexible hinge region; other site
755178005131	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
755178005132	ligand binding site [chemical binding]; other site
755178005133	flexible hinge region; other site
755178005134	Outer membrane efflux protein; Region: OEP; pfam02321
755178005135	Outer membrane efflux protein; Region: OEP; pfam02321
755178005136	Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455
755178005137	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
755178005138	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
755178005139	Conserved TM helix; Region: TM_helix; pfam05552
755178005140	dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416
755178005141	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
755178005142	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
755178005143	MASE1; Region: MASE1; cl17823
755178005144	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
755178005145	dimer interface [polypeptide binding]; other site
755178005146	phosphorylation site [posttranslational modification]
755178005147	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
755178005148	ATP binding site [chemical binding]; other site
755178005149	Mg2+ binding site [ion binding]; other site
755178005150	G-X-G motif; other site
755178005151	Response regulator receiver domain; Region: Response_reg; pfam00072
755178005152	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
755178005153	active site
755178005154	phosphorylation site [posttranslational modification]
755178005155	intermolecular recognition site; other site
755178005156	dimerization interface [polypeptide binding]; other site
755178005157	conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826
755178005158	family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187
755178005159	phosphate binding site [ion binding]; other site
755178005160	putative substrate binding pocket [chemical binding]; other site
755178005161	dimer interface [polypeptide binding]; other site
755178005162	Uncharacterized conserved protein (DUF2358); Region: DUF2358; pfam10184
755178005163	Protein of unknown function (DUF3493); Region: DUF3493; pfam11998
755178005164	Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312
755178005165	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
755178005166	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
755178005167	active site
755178005168	phosphorylation site [posttranslational modification]
755178005169	intermolecular recognition site; other site
755178005170	dimerization interface [polypeptide binding]; other site
755178005171	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
755178005172	DNA binding residues [nucleotide binding]
755178005173	dimerization interface [polypeptide binding]; other site
755178005174	S-layer homology domain; Region: SLH; pfam00395
755178005175	Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966
755178005176	Protein of unknown function (DUF3747); Region: DUF3747; pfam12565
755178005177	Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062
755178005178	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
755178005179	substrate binding pocket [chemical binding]; other site
755178005180	membrane-bound complex binding site; other site
755178005181	hinge residues; other site
755178005182	Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062
755178005183	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
755178005184	substrate binding pocket [chemical binding]; other site
755178005185	membrane-bound complex binding site; other site
755178005186	hinge residues; other site
755178005187	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
755178005188	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
755178005189	putative active site [active]
755178005190	heme pocket [chemical binding]; other site
755178005191	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
755178005192	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
755178005193	putative active site [active]
755178005194	heme pocket [chemical binding]; other site
755178005195	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
755178005196	putative active site [active]
755178005197	heme pocket [chemical binding]; other site
755178005198	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
755178005199	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
755178005200	metal binding site [ion binding]; metal-binding site
755178005201	active site
755178005202	I-site; other site
755178005203	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
755178005204	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
755178005205	PAS domain; Region: PAS_9; pfam13426
755178005206	putative active site [active]
755178005207	heme pocket [chemical binding]; other site
755178005208	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
755178005209	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
755178005210	metal binding site [ion binding]; metal-binding site
755178005211	active site
755178005212	I-site; other site
755178005213	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
755178005214	Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589
755178005215	POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478
755178005216	dnd system-associated protein 4; Region: dnd_assoc_4; TIGR04062
755178005217	Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980
755178005218	dimer interface [polypeptide binding]; other site
755178005219	[2Fe-2S] cluster binding site [ion binding]; other site
755178005220	PAS domain; Region: PAS_9; pfam13426
755178005221	NIL domain; Region: NIL; pfam09383
755178005222	4Fe-4S binding domain; Region: Fer4; pfam00037
755178005223	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
755178005224	glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352
755178005225	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
755178005226	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
755178005227	phosphopeptide binding site; other site
755178005228	PAS domain S-box; Region: sensory_box; TIGR00229
755178005229	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
755178005230	putative active site [active]
755178005231	heme pocket [chemical binding]; other site
755178005232	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
755178005233	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
755178005234	metal binding site [ion binding]; metal-binding site
755178005235	active site
755178005236	I-site; other site
755178005237	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
755178005238	Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075
755178005239	Lipase (class 2); Region: Lipase_2; pfam01674
755178005240	4-hydroxybenzoate polyprenyltransferase; Reviewed; Region: ubiA; PRK12870
755178005241	UbiA prenyltransferase family; Region: UbiA; pfam01040
755178005242	pantothenate kinase; Reviewed; Region: PRK13331
755178005243	Pchlide_reductase_N: N protein of the NB protein complex of Protochlorophyllide (Pchlide)_reductase. Pchlide reductase catalyzes the reductive formation of chlorophyllide (chlide) from protochlorophyllide (pchlide) during biosynthesis of chlorophylls and...; Region: Pchlide_reductase_N; cd01979
755178005244	light-independent protochlorophyllide reductase, N subunit; Region: DPOR_bchN; TIGR01279
755178005245	photochlorophyllide reductase subunit L; Region: chlL; CHL00072
755178005246	This family of proteins contains bchL and chlL. Protochlorophyllide reductase catalyzes the reductive formation of chlorophyllide from protochlorophyllide during biosynthesis of chlorophylls and bacteriochlorophylls. Three genes, bchL, bchN and bchB, are...; Region: Bchl_like; cd02032
755178005247	P-loop; other site
755178005248	bifunctional pantoate ligase/cytidylate kinase; Provisional; Region: PRK13477
755178005249	Pantoate-beta-alanine ligase; Region: PanC; cd00560
755178005250	active site
755178005251	ATP-binding site [chemical binding]; other site
755178005252	pantoate-binding site; other site
755178005253	HXXH motif; other site
755178005254	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
755178005255	CMP-binding site; other site
755178005256	The sites determining sugar specificity; other site
755178005257	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
755178005258	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
755178005259	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
755178005260	Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922
755178005261	Peptidase S8 family domain in Thermitase-like proteins; Region: Peptidases_S8_Thermitase_like; cd07484
755178005262	active site
755178005263	catalytic triad [active]
755178005264	TIGR00159 family protein; Region: TIGR00159
755178005265	PemK-like protein; Region: PemK; pfam02452
755178005266	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
755178005267	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
755178005268	Zn2+ binding site [ion binding]; other site
755178005269	Mg2+ binding site [ion binding]; other site
755178005270	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
755178005271	synthetase active site [active]
755178005272	NTP binding site [chemical binding]; other site
755178005273	metal binding site [ion binding]; metal-binding site
755178005274	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
755178005275	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
755178005276	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
755178005277	putative active site [active]
755178005278	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
755178005279	putative active site [active]
755178005280	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
755178005281	putative active site [active]
755178005282	arginine decarboxylase; Provisional; Region: PRK05354
755178005283	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830
755178005284	dimer interface [polypeptide binding]; other site
755178005285	active site
755178005286	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
755178005287	catalytic residues [active]
755178005288	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261
755178005289	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
755178005290	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
755178005291	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
755178005292	PAP_fibrillin; Region: PAP_fibrillin; pfam04755
755178005293	Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016
755178005294	putative phosphate acyltransferase; Provisional; Region: PRK05331
755178005295	Uncharacterized conserved protein [Function unknown]; Region: COG3937
755178005296	Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637
755178005297	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
755178005298	motif II; other site
755178005299	cellulose synthase subunit BcsC; Provisional; Region: PRK11447
755178005300	BolA-like protein; Region: BolA; pfam01722
755178005301	Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028
755178005302	putative GSH binding site [chemical binding]; other site
755178005303	catalytic residues [active]
755178005304	Protein of unknown function (DUF3685); Region: DUF3685; pfam12452
755178005305	cell division protein; Validated; Region: ftsH; CHL00176
755178005306	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
755178005307	Walker A motif; other site
755178005308	ATP binding site [chemical binding]; other site
755178005309	Walker B motif; other site
755178005310	arginine finger; other site
755178005311	Peptidase family M41; Region: Peptidase_M41; pfam01434
755178005312	4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337
755178005313	UbiA prenyltransferase family; Region: UbiA; pfam01040
755178005314	Predicted transmembrane sensor domain [Signal transduction mechanisms]; Region: COG4252
755178005315	CHASE2 domain; Region: CHASE2; pfam05226
755178005316	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
755178005317	Catalytic domain of Protein Kinases; Region: PKc; cd00180
755178005318	active site
755178005319	ATP binding site [chemical binding]; other site
755178005320	substrate binding site [chemical binding]; other site
755178005321	activation loop (A-loop); other site
755178005322	Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576
755178005323	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
755178005324	dimer interface [polypeptide binding]; other site
755178005325	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
755178005326	molecular chaperone DnaK; Provisional; Region: PRK13411
755178005327	Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234
755178005328	nucleotide binding site [chemical binding]; other site
755178005329	NEF interaction site [polypeptide binding]; other site
755178005330	SBD interface [polypeptide binding]; other site
755178005331	photosystem II complex extrinsic protein precursor U; Provisional; Region: psbU; PRK02515
755178005332	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
755178005333	Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by...; Region: PRX_1cys; cd03016
755178005334	dimer interface [polypeptide binding]; other site
755178005335	decamer (pentamer of dimers) interface [polypeptide binding]; other site
755178005336	catalytic triad [active]
755178005337	PetM family of cytochrome b6f complex subunit 7; Region: PetM; pfam08041
755178005338	geranylgeranyl reductase; Region: ChlP; TIGR02028
755178005339	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
755178005340	G1P_TT_long represents the long form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_long; cd04189
755178005341	glucose-1-phosphate thymidylylransferase, long form; Region: rmlA_long; TIGR01208
755178005342	substrate binding site; other site
755178005343	metal-binding site
755178005344	Oligomer interface; other site
755178005345	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
755178005346	riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326
755178005347	Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284
755178005348	catalytic motif [active]
755178005349	Zn binding site [ion binding]; other site
755178005350	RibD C-terminal domain; Region: RibD_C; cl17279
755178005351	bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759
755178005352	Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139
755178005353	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534
755178005354	metal binding site [ion binding]; metal-binding site
755178005355	16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274
755178005356	Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030
755178005357	UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770
755178005358	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
755178005359	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
755178005360	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
755178005361	dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; cl17405
755178005362	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366
755178005363	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
755178005364	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
755178005365	tellurium resistance terB-like protein; Region: terB_like; cd07177
755178005366	metal binding site [ion binding]; metal-binding site
755178005367	Mo-dependent nitrogenase C-terminus; Region: Mo-nitro_C; pfam06967
755178005368	glycerol kinase; Provisional; Region: glpK; PRK00047
755178005369	Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786
755178005370	N- and C-terminal domain interface [polypeptide binding]; other site
755178005371	active site
755178005372	MgATP binding site [chemical binding]; other site
755178005373	catalytic site [active]
755178005374	metal binding site [ion binding]; metal-binding site
755178005375	glycerol binding site [chemical binding]; other site
755178005376	homotetramer interface [polypeptide binding]; other site
755178005377	homodimer interface [polypeptide binding]; other site
755178005378	FBP binding site [chemical binding]; other site
755178005379	protein IIAGlc interface [polypeptide binding]; other site
755178005380	Predicted RNA-binding protein, contains TRAM domain [General function prediction only]; Region: COG3269
755178005381	23S rRNA (uracil-5-)-methyltransferase RumA; Region: rumA; TIGR00479
755178005382	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709
755178005383	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
755178005384	S-adenosylmethionine binding site [chemical binding]; other site
755178005385	ABC-2 type transporter; Region: ABC2_membrane; cl17235
755178005386	ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698
755178005387	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
755178005388	active site
755178005389	catalytic residues [active]
755178005390	DNA binding site [nucleotide binding]
755178005391	Int/Topo IB signature motif; other site
755178005392	Prim_Pol: Primase-polymerase (primpol) domain of the type found in bifunctional replicases from archaeal plasmids, including ORF904 protein of the crenarchaeal plasmid pRN1 from Sulfolobus islandicus (pRN1 primpol). These primpol domains belong to the...; Region: Prim_Pol; cd04859
755178005393	nucleotide binding site [chemical binding]; other site
755178005394	polymerase nucleotide-binding site; other site
755178005395	primase nucleotide-binding site [nucleotide binding]; other site
755178005396	DNA-binding residues [nucleotide binding]; DNA binding site
755178005397	Primase C terminal 2 (PriCT-2); Region: PriCT_2; pfam08707
755178005398	YacP-like NYN domain; Region: NYN_YacP; pfam05991
755178005399	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
755178005400	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
755178005401	Walker A/P-loop; other site
755178005402	ATP binding site [chemical binding]; other site
755178005403	Q-loop/lid; other site
755178005404	ABC transporter signature motif; other site
755178005405	Walker B; other site
755178005406	D-loop; other site
755178005407	H-loop/switch region; other site
755178005408	hypothetical protein; Provisional; Region: PRK13683
755178005409	Photosystem II, DII subunit (also called Q(A)); Region: psbD; TIGR01152
755178005410	pheophytin binding site; other site
755178005411	chlorophyll binding site; other site
755178005412	quinone binding site; other site
755178005413	Fe binding site [ion binding]; other site
755178005414	Methyltransferase domain; Region: Methyltransf_23; pfam13489
755178005415	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
755178005416	S-adenosylmethionine binding site [chemical binding]; other site
755178005417	ATP-dependent protease La (LON) domain; Region: LON; pfam02190
755178005418	Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956
755178005419	PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877
755178005420	putative active site [active]
755178005421	Predicted bile acid beta-glucosidase [Carbohydrate transport and metabolism]; Region: COG4354
755178005422	beta-Glucocerebrosidase 2 N terminal; Region: GBA2_N; pfam12215
755178005423	Protein of unknown function, DUF608; Region: DUF608; pfam04685
755178005424	S23 ribosomal protein; Region: Ribosomal_S23p; cl05287
755178005425	potassium/proton antiporter; Reviewed; Region: PRK05326
755178005426	A subgroup of L-lactate dehydrogenases; Region: LDH_2; cd05292
755178005427	L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771
755178005428	NAD binding site [chemical binding]; other site
755178005429	dimer interface [polypeptide binding]; other site
755178005430	substrate binding site [chemical binding]; other site
755178005431	tetramer (dimer of dimers) interface [polypeptide binding]; other site
755178005432	exopolysaccharide transport protein family; Region: eps_transp_fam; TIGR01005
755178005433	Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206
755178005434	Protein of unknown function (DUF1292); Region: DUF1292; pfam06949
755178005435	Protein of unknown function (DUF3727); Region: DUF3727; pfam12527
755178005436	50S ribosome-binding GTPase; Region: MMR_HSR1; pfam01926
755178005437	G1 box; other site
755178005438	GTP/Mg2+ binding site [chemical binding]; other site
755178005439	G2 box; other site
755178005440	Switch I region; other site
755178005441	G3 box; other site
755178005442	Switch II region; other site
755178005443	Uncharacterized protein/domain associated with GTPases [Function unknown]; Region: COG3597
755178005444	NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; cl00566
755178005445	NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233
755178005446	pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005
755178005447	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
755178005448	RNA binding surface [nucleotide binding]; other site
755178005449	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
755178005450	active site
755178005451	GTP-binding protein HflX; Region: GTP_HflX; TIGR03156
755178005452	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
755178005453	HflX GTPase family; Region: HflX; cd01878
755178005454	G1 box; other site
755178005455	GTP/Mg2+ binding site [chemical binding]; other site
755178005456	Switch I region; other site
755178005457	G2 box; other site
755178005458	G3 box; other site
755178005459	Switch II region; other site
755178005460	G4 box; other site
755178005461	G5 box; other site
755178005462	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
755178005463	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
755178005464	Sulfate transporter family; Region: Sulfate_transp; pfam00916
755178005465	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
755178005466	Response regulator receiver domain; Region: Response_reg; pfam00072
755178005467	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
755178005468	active site
755178005469	phosphorylation site [posttranslational modification]
755178005470	intermolecular recognition site; other site
755178005471	dimerization interface [polypeptide binding]; other site
755178005472	ribosomal protein L32; Validated; Region: rpl32; CHL00152
755178005473	D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 4) [Cell envelope biogenesis, outer membrane]; Region: DacB; COG2027
755178005474	Domain of unknown function (DUF4330); Region: DUF4330; pfam14221
755178005475	Methyltransferase domain; Region: Methyltransf_31; pfam13847
755178005476	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
755178005477	S-adenosylmethionine binding site [chemical binding]; other site
755178005478	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
755178005479	Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of  glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570
755178005480	C-terminal domain interface [polypeptide binding]; other site
755178005481	GSH binding site (G-site) [chemical binding]; other site
755178005482	dimer interface [polypeptide binding]; other site
755178005483	Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354
755178005484	Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661
755178005485	ABC1 family; Region: ABC1; cl17513
755178005486	MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756
755178005487	MoaE homodimer interface [polypeptide binding]; other site
755178005488	MoaD interaction [polypeptide binding]; other site
755178005489	active site residues [active]
755178005490	Protein of unknown function (DUF3571); Region: DUF3571; pfam12095
755178005491	Methyltransferase domain; Region: Methyltransf_31; pfam13847
755178005492	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
755178005493	S-adenosylmethionine binding site [chemical binding]; other site
755178005494	Uncharacterized BCR, COG1649; Region: DUF187; pfam02638
755178005495	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1649
755178005496	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153
755178005497	PIN domain; Region: PIN_3; cl17397
755178005498	acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654
755178005499	RNA polymerases M/15 Kd subunit; Region: RNA_POL_M_15KD; cl02717
755178005500	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
755178005501	Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763
755178005502	Manganese-stabilising protein / photosystem II polypeptide; Region: MSP; pfam01716
755178005503	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
755178005504	catalytic center binding site [active]
755178005505	ATP binding site [chemical binding]; other site
755178005506	HEAT repeats; Region: HEAT_2; pfam13646
755178005507	HEAT repeats; Region: HEAT_2; pfam13646
755178005508	E-Z type HEAT repeats; Region: EZ_HEAT; smart00567
755178005509	HEAT repeats; Region: HEAT_2; pfam13646
755178005510	Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091
755178005511	4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648
755178005512	PAS domain S-box; Region: sensory_box; TIGR00229
755178005513	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
755178005514	putative active site [active]
755178005515	heme pocket [chemical binding]; other site
755178005516	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
755178005517	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
755178005518	metal binding site [ion binding]; metal-binding site
755178005519	active site
755178005520	I-site; other site
755178005521	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
755178005522	heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082
755178005523	glutamine synthetase, type I; Region: GlnA; TIGR00653
755178005524	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
755178005525	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
755178005526	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
755178005527	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
755178005528	active site
755178005529	phosphorylation site [posttranslational modification]
755178005530	intermolecular recognition site; other site
755178005531	dimerization interface [polypeptide binding]; other site
755178005532	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
755178005533	DNA binding site [nucleotide binding]
755178005534	AAA domain; Region: AAA_33; pfam13671
755178005535	AAA domain; Region: AAA_17; pfam13207
755178005536	WYL domain; Region: WYL; pfam13280
755178005537	XisI protein; Region: XisI; pfam08869
755178005538	50S ribosome-binding GTPase; Region: MMR_HSR1; pfam01926
755178005539	G1 box; other site
755178005540	GTP/Mg2+ binding site [chemical binding]; other site
755178005541	G2 box; other site
755178005542	G3 box; other site
755178005543	Switch II region; other site
755178005544	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
755178005545	G1 box; other site
755178005546	GTP/Mg2+ binding site [chemical binding]; other site
755178005547	G2 box; other site
755178005548	Switch I region; other site
755178005549	G3 box; other site
755178005550	Switch II region; other site
755178005551	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
755178005552	G1 box; other site
755178005553	GTP/Mg2+ binding site [chemical binding]; other site
755178005554	G2 box; other site
755178005555	Switch I region; other site
755178005556	G3 box; other site
755178005557	Switch II region; other site
755178005558	G4 box; other site
755178005559	G5 box; other site
755178005560	PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861
755178005561	putative active site [active]
755178005562	DDE superfamily endonuclease; Region: DDE_5; cl17874
755178005563	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
755178005564	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
755178005565	Walker A motif; other site
755178005566	ATP binding site [chemical binding]; other site
755178005567	Walker B motif; other site
755178005568	arginine finger; other site
755178005569	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
755178005570	PAS domain; Region: PAS_9; pfam13426
755178005571	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
755178005572	putative active site [active]
755178005573	heme pocket [chemical binding]; other site
755178005574	PAS domain S-box; Region: sensory_box; TIGR00229
755178005575	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
755178005576	PAS fold; Region: PAS_3; pfam08447
755178005577	putative active site [active]
755178005578	heme pocket [chemical binding]; other site
755178005579	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
755178005580	dimer interface [polypeptide binding]; other site
755178005581	phosphorylation site [posttranslational modification]
755178005582	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
755178005583	ATP binding site [chemical binding]; other site
755178005584	Mg2+ binding site [ion binding]; other site
755178005585	G-X-G motif; other site
755178005586	Response regulator receiver domain; Region: Response_reg; pfam00072
755178005587	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
755178005588	active site
755178005589	phosphorylation site [posttranslational modification]
755178005590	intermolecular recognition site; other site
755178005591	dimerization interface [polypeptide binding]; other site
755178005592	Response regulator receiver domain; Region: Response_reg; pfam00072
755178005593	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
755178005594	active site
755178005595	phosphorylation site [posttranslational modification]
755178005596	intermolecular recognition site; other site
755178005597	dimerization interface [polypeptide binding]; other site
755178005598	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
755178005599	binding surface
755178005600	TPR motif; other site
755178005601	Tetratricopeptide repeat; Region: TPR_12; pfam13424
755178005602	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
755178005603	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
755178005604	Probable transposase; Region: OrfB_IS605; pfam01385
755178005605	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
755178005606	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
755178005607	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
755178005608	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
755178005609	protein binding site [polypeptide binding]; other site
755178005610	DDE superfamily endonuclease; Region: DDE_3; pfam13358
755178005611	Homeodomain-like domain; Region: HTH_23; pfam13384
755178005612	Winged helix-turn helix; Region: HTH_29; pfam13551
755178005613	Winged helix-turn helix; Region: HTH_33; pfam13592
755178005614	Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210
755178005615	filamentous hemagglutinin family N-terminal domain; Region: adhes_NPXG; TIGR01901
755178005616	Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210
755178005617	TPR repeat; Region: TPR_11; pfam13414
755178005618	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
755178005619	binding surface
755178005620	TPR motif; other site
755178005621	Tetratricopeptide repeat; Region: TPR_12; pfam13424
755178005622	Tetratricopeptide repeat; Region: TPR_12; pfam13424
755178005623	Tetratricopeptide repeat; Region: TPR_12; pfam13424
755178005624	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
755178005625	binding surface
755178005626	TPR motif; other site
755178005627	Tetratricopeptide repeat; Region: TPR_12; pfam13424
755178005628	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4995
755178005629	Tetratricopeptide repeat; Region: TPR_16; pfam13432
755178005630	Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831
755178005631	POTRA domain, ShlB-type; Region: POTRA_2; pfam08479
755178005632	Surface antigen; Region: Bac_surface_Ag; pfam01103
755178005633	Uncharacterized conserved protein [Function unknown]; Region: COG2361
755178005634	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
755178005635	active site
755178005636	NTP binding site [chemical binding]; other site
755178005637	metal binding triad [ion binding]; metal-binding site
755178005638	antibiotic binding site [chemical binding]; other site
755178005639	Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445
755178005640	isocitrate dehydrogenase; Validated; Region: PRK07362
755178005641	Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118
755178005642	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
755178005643	SmpB-tmRNA interface; other site
755178005644	Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242
755178005645	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
755178005646	S-adenosylmethionine binding site [chemical binding]; other site
755178005647	Predicted membrane protein (DUF2214); Region: DUF2214; pfam09980
755178005648	Pyruvate formate lyase 1; Region: PFL1; cd01678
755178005649	formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255
755178005650	coenzyme A binding site [chemical binding]; other site
755178005651	active site
755178005652	catalytic residues [active]
755178005653	glycine loop; other site
755178005654	Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661
755178005655	ABC1 family; Region: ABC1; cl17513
755178005656	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
755178005657	active site
755178005658	Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065
755178005659	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
755178005660	active site
755178005661	Pyruvate decarboxylase and related thiamine pyrophosphate-requiring enzymes [Carbohydrate transport and metabolism / Coenzyme metabolism / General function prediction only]; Region: COG3961
755178005662	Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038
755178005663	dimer interface [polypeptide binding]; other site
755178005664	PYR/PP interface [polypeptide binding]; other site
755178005665	TPP binding site [chemical binding]; other site
755178005666	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
755178005667	Thiamine pyrophosphate (TPP) family, PDC_IPDC subfamily, TPP-binding module; composed of proteins similar to pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC, a key enzyme in alcoholic fermentation, catalyzes the conversion of...; Region: TPP_PDC_IPDC; cd02005
755178005668	TPP-binding site [chemical binding]; other site
755178005669	dimer interface [polypeptide binding]; other site
755178005670	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
755178005671	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
755178005672	putative substrate translocation pore; other site
755178005673	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
755178005674	active site
755178005675	NTP binding site [chemical binding]; other site
755178005676	metal binding triad [ion binding]; metal-binding site
755178005677	antibiotic binding site [chemical binding]; other site
755178005678	hypothetical protein; Provisional; Region: PRK05409
755178005679	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
755178005680	Multicopper oxidase; Region: Cu-oxidase_2; pfam07731
755178005681	leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301
755178005682	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
755178005683	Catalytic domain of Protein Kinases; Region: PKc; cd00180
755178005684	active site
755178005685	ATP binding site [chemical binding]; other site
755178005686	substrate binding site [chemical binding]; other site
755178005687	activation loop (A-loop); other site
755178005688	Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310
755178005689	Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974
755178005690	putative metal binding site [ion binding]; other site
755178005691	Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310
755178005692	Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974
755178005693	putative metal binding site [ion binding]; other site
755178005694	Response regulator receiver domain; Region: Response_reg; pfam00072
755178005695	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
755178005696	active site
755178005697	phosphorylation site [posttranslational modification]
755178005698	intermolecular recognition site; other site
755178005699	dimerization interface [polypeptide binding]; other site
755178005700	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
755178005701	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
755178005702	metal binding site [ion binding]; metal-binding site
755178005703	active site
755178005704	I-site; other site
755178005705	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
755178005706	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
755178005707	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
755178005708	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
755178005709	dimer interface [polypeptide binding]; other site
755178005710	phosphorylation site [posttranslational modification]
755178005711	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
755178005712	ATP binding site [chemical binding]; other site
755178005713	Mg2+ binding site [ion binding]; other site
755178005714	G-X-G motif; other site
755178005715	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
755178005716	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
755178005717	active site
755178005718	phosphorylation site [posttranslational modification]
755178005719	intermolecular recognition site; other site
755178005720	dimerization interface [polypeptide binding]; other site
755178005721	Domain of unknown function (DUF4341); Region: DUF4341; pfam14241
755178005722	Predicted transporter component [General function prediction only]; Region: COG2391
755178005723	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
755178005724	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
755178005725	Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027
755178005726	ligand-binding site [chemical binding]; other site
755178005727	Integral membrane protein DUF92; Region: DUF92; pfam01940
755178005728	GUN4-like; Region: GUN4; pfam05419
755178005729	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
755178005730	The substrate-binding component of ABC-type thermophilic oligopeptide-binding protein Hb8-like import systems, contains the type 2 periplasmic binding fold; Region: PBP2_thermophilic_Hb8_like; cd08513
755178005731	peptide binding site [polypeptide binding]; other site
755178005732	dimer interface [polypeptide binding]; other site
755178005733	Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170
755178005734	elongation factor G; Reviewed; Region: PRK12740
755178005735	G1 box; other site
755178005736	putative GEF interaction site [polypeptide binding]; other site
755178005737	GTP/Mg2+ binding site [chemical binding]; other site
755178005738	Switch I region; other site
755178005739	G2 box; other site
755178005740	G3 box; other site
755178005741	Switch II region; other site
755178005742	G4 box; other site
755178005743	G5 box; other site
755178005744	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
755178005745	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
755178005746	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
755178005747	Transcriptional accessory protein [Transcription]; Region: Tex; COG2183
755178005748	Tex-like protein N-terminal domain; Region: Tex_N; pfam09371
755178005749	Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732
755178005750	S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685
755178005751	RNA binding site [nucleotide binding]; other site
755178005752	Protein of unknown function (DUF721); Region: DUF721; pfam05258
755178005753	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
755178005754	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933
755178005755	Domain of unknown function (DUF4327); Region: DUF4327; pfam14217
755178005756	Uncharacterized conserved protein [Function unknown]; Region: COG2006
755178005757	Domain of unknown function (DUF362); Region: DUF362; pfam04015
755178005758	cell division protein; Validated; Region: ftsH; CHL00176
755178005759	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
755178005760	Walker A motif; other site
755178005761	ATP binding site [chemical binding]; other site
755178005762	Walker B motif; other site
755178005763	arginine finger; other site
755178005764	Peptidase family M41; Region: Peptidase_M41; pfam01434
755178005765	Type II restriction enzyme, methylase subunits [Defense mechanisms]; Region: COG1002
755178005766	Eco57I restriction-modification methylase; Region: Eco57I; pfam07669
755178005767	TaqI-like C-terminal specificity domain; Region: TaqI_C; pfam12950
755178005768	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
755178005769	dimer interface [polypeptide binding]; other site
755178005770	phosphorylation site [posttranslational modification]
755178005771	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
755178005772	ATP binding site [chemical binding]; other site
755178005773	Mg2+ binding site [ion binding]; other site
755178005774	G-X-G motif; other site
755178005775	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
755178005776	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
755178005777	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
755178005778	TM-ABC transporter signature motif; other site
755178005779	Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354
755178005780	folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317
755178005781	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
755178005782	ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757
755178005783	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
755178005784	homodimer interface [polypeptide binding]; other site
755178005785	oligonucleotide binding site [chemical binding]; other site
755178005786	hypothetical protein; Reviewed; Region: PRK12497
755178005787	Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426
755178005788	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
755178005789	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
755178005790	Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853
755178005791	Bacterial Micro-Compartment (BMC)-like domain 1 repeat 1; Region: BMC_like_1_repeat1; cd07051
755178005792	putative hexamer interface [polypeptide binding]; other site
755178005793	putative hexagonal pore; other site
755178005794	Bacterial Micro-Compartment (BMC) domain; Region: BMC; cl01982
755178005795	Hexamer interface [polypeptide binding]; other site
755178005796	Hexagonal pore residue; other site
755178005797	Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147
755178005798	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
755178005799	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
755178005800	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
755178005801	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
755178005802	inhibitor-cofactor binding pocket; inhibition site
755178005803	pyridoxal 5'-phosphate binding site [chemical binding]; other site
755178005804	catalytic residue [active]
755178005805	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
755178005806	S-adenosylmethionine binding site [chemical binding]; other site
755178005807	Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437
755178005808	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
755178005809	active site
755178005810	phosphorylation site [posttranslational modification]
755178005811	intermolecular recognition site; other site
755178005812	dimerization interface [polypeptide binding]; other site
755178005813	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
755178005814	Zn2+ binding site [ion binding]; other site
755178005815	Mg2+ binding site [ion binding]; other site
755178005816	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
755178005817	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
755178005818	putative active site [active]
755178005819	substrate binding site [chemical binding]; other site
755178005820	putative cosubstrate binding site; other site
755178005821	catalytic site [active]
755178005822	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
755178005823	substrate binding site [chemical binding]; other site
755178005824	Cupin domain; Region: Cupin_2; cl17218
755178005825	CpcD/allophycocyanin linker domain; Region: CpcD; pfam01383
755178005826	allophycocyanin beta subunit; Region: apcB; CHL00088
755178005827	Phycobilisome protein; Region: Phycobilisome; cl08227
755178005828	Predicted nuclease of restriction endonuclease-like fold [General function prediction only]; Region: COG3372
755178005829	Protein of unknown function (DUF790); Region: DUF790; pfam05626
755178005830	Protein of unknown function (DUF2605); Region: DUF2605; pfam10792
755178005831	Protein of unknown function (DUF2973); Region: DUF2973; pfam11189
755178005832	2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959
755178005833	intersubunit interface [polypeptide binding]; other site
755178005834	active site
755178005835	catalytic residue [active]
755178005836	Caspase domain; Region: Peptidase_C14; pfam00656
755178005837	Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989
755178005838	Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750
755178005839	Type IV leader peptidase family; Region: Peptidase_A24; pfam01478
755178005840	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399
755178005841	peptide chain release factor 2; Validated; Region: prfB; PRK00578
755178005842	This domain is found in peptide chain release factors; Region: PCRF; smart00937
755178005843	RF-1 domain; Region: RF-1; pfam00472
755178005844	Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443
755178005845	Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170
755178005846	nucleotide binding site [chemical binding]; other site
755178005847	putative NEF/HSP70 interaction site [polypeptide binding]; other site
755178005848	SBD interface [polypeptide binding]; other site
755178005849	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
755178005850	GrpE; Region: GrpE; pfam01025
755178005851	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cl03075
755178005852	dimer interface [polypeptide binding]; other site
755178005853	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
755178005854	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
755178005855	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
755178005856	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
755178005857	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
755178005858	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
755178005859	phosphopeptide binding site; other site
755178005860	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
755178005861	structural tetrad; other site
755178005862	FOG: WD40 repeat [General function prediction only]; Region: COG2319
755178005863	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
755178005864	EamA-like transporter family; Region: EamA; pfam00892
755178005865	EamA-like transporter family; Region: EamA; pfam00892
755178005866	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
755178005867	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
755178005868	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
755178005869	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
755178005870	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
755178005871	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
755178005872	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
755178005873	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
755178005874	TspO/MBR family; Region: TspO_MBR; cl01379
755178005875	methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252
755178005876	Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717
755178005877	substrate binding site [chemical binding]; other site
755178005878	active site
755178005879	Ycf66 protein N-terminus; Region: Ycf66_N; pfam07444
755178005880	HEAT repeats; Region: HEAT_2; pfam13646
755178005881	Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin; Region: ARM; cl02500
755178005882	protein binding surface [polypeptide binding]; other site
755178005883	HEAT repeats; Region: HEAT_2; pfam13646
755178005884	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
755178005885	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
755178005886	Walker A/P-loop; other site
755178005887	ATP binding site [chemical binding]; other site
755178005888	Q-loop/lid; other site
755178005889	ABC transporter signature motif; other site
755178005890	Walker B; other site
755178005891	D-loop; other site
755178005892	H-loop/switch region; other site
755178005893	CHASE domain; Region: CHASE; cl01369
755178005894	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
755178005895	dimer interface [polypeptide binding]; other site
755178005896	phosphorylation site [posttranslational modification]
755178005897	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
755178005898	ATP binding site [chemical binding]; other site
755178005899	Mg2+ binding site [ion binding]; other site
755178005900	G-X-G motif; other site
755178005901	Response regulator receiver domain; Region: Response_reg; pfam00072
755178005902	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
755178005903	active site
755178005904	phosphorylation site [posttranslational modification]
755178005905	intermolecular recognition site; other site
755178005906	dimerization interface [polypeptide binding]; other site
755178005907	DNA polymerase III subunit beta; Validated; Region: PRK05643
755178005908	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
755178005909	putative DNA binding surface [nucleotide binding]; other site
755178005910	dimer interface [polypeptide binding]; other site
755178005911	beta-clamp/clamp loader binding surface; other site
755178005912	beta-clamp/translesion DNA polymerase binding surface; other site
755178005913	DNA uptake protein and related DNA-binding proteins [DNA replication, recombination, and repair]; Region: ComEA; COG1555
755178005914	Photosystem I protein M (PsaM); Region: PsaM; pfam07465
755178005915	Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385
755178005916	Integrin alpha (beta-propellor repeats); Region: Int_alpha; smart00191
755178005917	Integrin alpha (beta-propellor repeats); Region: Int_alpha; smart00191
755178005918	Integrin alpha (beta-propellor repeats); Region: Int_alpha; smart00191
755178005919	Integrin alpha (beta-propellor repeats); Region: Int_alpha; smart00191
755178005920	Domains in Na-Ca exchangers and integrin-beta4; Region: Calx_beta; smart00237
755178005921	Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog) [Signal transduction mechanisms]; Region: COG3476
755178005922	Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006
755178005923	dimer interface [polypeptide binding]; other site
755178005924	active site
755178005925	Phytoene/squalene synthetase [Lipid metabolism]; Region: ERG9; COG1562
755178005926	substrate binding pocket [chemical binding]; other site
755178005927	substrate-Mg2+ binding site; other site
755178005928	aspartate-rich region 1; other site
755178005929	aspartate-rich region 2; other site
755178005930	Response regulator receiver domain; Region: Response_reg; pfam00072
755178005931	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
755178005932	active site
755178005933	phosphorylation site [posttranslational modification]
755178005934	intermolecular recognition site; other site
755178005935	dimerization interface [polypeptide binding]; other site
755178005936	Response regulator receiver domain; Region: Response_reg; pfam00072
755178005937	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
755178005938	active site
755178005939	phosphorylation site [posttranslational modification]
755178005940	intermolecular recognition site; other site
755178005941	dimerization interface [polypeptide binding]; other site
755178005942	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cd00588
755178005943	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
755178005944	TPR motif; other site
755178005945	binding surface
755178005946	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
755178005947	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
755178005948	dimerization interface [polypeptide binding]; other site
755178005949	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
755178005950	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
755178005951	dimer interface [polypeptide binding]; other site
755178005952	putative CheW interface [polypeptide binding]; other site
755178005953	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
755178005954	putative binding surface; other site
755178005955	active site
755178005956	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
755178005957	ATP binding site [chemical binding]; other site
755178005958	Mg2+ binding site [ion binding]; other site
755178005959	G-X-G motif; other site
755178005960	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256
755178005961	Response regulator receiver domain; Region: Response_reg; pfam00072
755178005962	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
755178005963	active site
755178005964	phosphorylation site [posttranslational modification]
755178005965	intermolecular recognition site; other site
755178005966	dimerization interface [polypeptide binding]; other site
755178005967	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cl00197
755178005968	active site
755178005969	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cl00197
755178005970	active site
755178005971	TPR repeat; Region: TPR_11; pfam13414
755178005972	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
755178005973	binding surface
755178005974	TPR motif; other site
755178005975	Phycobilisome protein; Region: Phycobilisome; cl08227
755178005976	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
755178005977	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
755178005978	catalytic loop [active]
755178005979	iron binding site [ion binding]; other site
755178005980	Predicted hydrocarbon binding protein (contains V4R domain) [General function prediction only]; Region: COG1719
755178005981	V4R domain; Region: V4R; cl15268
755178005982	Phycobilisome protein; Region: Phycobilisome; cl08227
755178005983	Predicted hydrocarbon binding protein (contains V4R domain) [General function prediction only]; Region: COG1719
755178005984	V4R domain; Region: V4R; pfam02830
755178005985	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
755178005986	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
755178005987	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
755178005988	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
755178005989	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
755178005990	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
755178005991	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
755178005992	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
755178005993	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
755178005994	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
755178005995	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
755178005996	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
755178005997	Mechanosensitive ion channel; Region: MS_channel; pfam00924
755178005998	Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004
755178005999	cytochrome c-550; Provisional; Region: psbV; cl17239
755178006000	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
755178006001	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
755178006002	Walker A/P-loop; other site
755178006003	ATP binding site [chemical binding]; other site
755178006004	Q-loop/lid; other site
755178006005	ABC transporter signature motif; other site
755178006006	Walker B; other site
755178006007	D-loop; other site
755178006008	H-loop/switch region; other site
755178006009	Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179
755178006010	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
755178006011	active site
755178006012	motif I; other site
755178006013	motif II; other site
755178006014	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
755178006015	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
755178006016	substrate binding pocket [chemical binding]; other site
755178006017	chain length determination region; other site
755178006018	substrate-Mg2+ binding site; other site
755178006019	catalytic residues [active]
755178006020	aspartate-rich region 1; other site
755178006021	active site lid residues [active]
755178006022	aspartate-rich region 2; other site
755178006023	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
755178006024	Fe3+-siderophore binding domain FhuD.  These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146
755178006025	siderophore binding site; other site
755178006026	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
755178006027	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
755178006028	ABC-ATPase subunit  interface; other site
755178006029	dimer interface [polypeptide binding]; other site
755178006030	putative PBP binding regions; other site
755178006031	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
755178006032	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
755178006033	Walker A/P-loop; other site
755178006034	ATP binding site [chemical binding]; other site
755178006035	Q-loop/lid; other site
755178006036	ABC transporter signature motif; other site
755178006037	Walker B; other site
755178006038	D-loop; other site
755178006039	H-loop/switch region; other site
755178006040	AMIN domain; Region: AMIN; pfam11741
755178006041	TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786
755178006042	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
755178006043	N-terminal plug; other site
755178006044	ligand-binding site [chemical binding]; other site
755178006045	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
755178006046	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
755178006047	intersubunit interface [polypeptide binding]; other site
755178006048	TRX-like [2Fe-2S] Ferredoxin (Fd) family, Sucrase subfamily; composed of proteins with similarity to a novel plant enzyme, isolated from potato, which contains a Fd-like domain and exhibits sucrolytic activity. The putative active site of the Fd-like...; Region: TRX_Fd_Sucrase; cd03062
755178006049	putative dimer interface [polypeptide binding]; other site
755178006050	putative [2Fe-2S] cluster binding site [ion binding]; other site
755178006051	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
755178006052	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
755178006053	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
755178006054	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
755178006055	AMIN domain; Region: AMIN; pfam11741
755178006056	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
755178006057	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
755178006058	N-terminal plug; other site
755178006059	ligand-binding site [chemical binding]; other site
755178006060	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
755178006061	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
755178006062	intersubunit interface [polypeptide binding]; other site
755178006063	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
755178006064	active site
755178006065	NTP binding site [chemical binding]; other site
755178006066	metal binding triad [ion binding]; metal-binding site
755178006067	hypothetical protein; Provisional; Region: PHA02888
755178006068	Tetratricopeptide repeat; Region: TPR_12; pfam13424
755178006069	Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309
755178006070	Leucine-rich repeats; other site
755178006071	Leucine rich repeat; Region: LRR_8; pfam13855
755178006072	Substrate binding site [chemical binding]; other site
755178006073	Leucine rich repeat; Region: LRR_8; pfam13855
755178006074	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
755178006075	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
755178006076	N-terminal plug; other site
755178006077	ligand-binding site [chemical binding]; other site
755178006078	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
755178006079	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
755178006080	intersubunit interface [polypeptide binding]; other site
755178006081	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
755178006082	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
755178006083	H+ Antiporter protein; Region: 2A0121; TIGR00900
755178006084	H+ Antiporter protein; Region: 2A0121; TIGR00900
755178006085	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
755178006086	putative substrate translocation pore; other site
755178006087	AMIN domain; Region: AMIN; pfam11741
755178006088	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
755178006089	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
755178006090	N-terminal plug; other site
755178006091	ligand-binding site [chemical binding]; other site
755178006092	Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472
755178006093	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
755178006094	Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811
755178006095	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
755178006096	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
755178006097	AMIN domain; Region: AMIN; pfam11741
755178006098	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
755178006099	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
755178006100	N-terminal plug; other site
755178006101	ligand-binding site [chemical binding]; other site
755178006102	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
755178006103	AMIN domain; Region: AMIN; pfam11741
755178006104	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
755178006105	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
755178006106	N-terminal plug; other site
755178006107	ligand-binding site [chemical binding]; other site
755178006108	Fe3+-siderophore binding domain FhuD.  These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146
755178006109	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
755178006110	siderophore binding site; other site
755178006111	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
755178006112	H+ Antiporter protein; Region: 2A0121; TIGR00900
755178006113	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
755178006114	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
755178006115	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
755178006116	Walker A/P-loop; other site
755178006117	ATP binding site [chemical binding]; other site
755178006118	Q-loop/lid; other site
755178006119	ABC transporter signature motif; other site
755178006120	Walker B; other site
755178006121	D-loop; other site
755178006122	H-loop/switch region; other site
755178006123	Predicted metal-binding protein [Function unknown]; Region: COG5469
755178006124	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
755178006125	Fe3+-siderophore binding domain FhuD.  These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146
755178006126	siderophore binding site; other site
755178006127	AMIN domain; Region: AMIN; pfam11741
755178006128	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
755178006129	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
755178006130	N-terminal plug; other site
755178006131	ligand-binding site [chemical binding]; other site
755178006132	Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026
755178006133	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
755178006134	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
755178006135	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4642
755178006136	MORN repeat; Region: MORN; cl14787
755178006137	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4642
755178006138	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4642
755178006139	MORN repeat; Region: MORN; cl14787
755178006140	glutathione synthetase; Provisional; Region: PRK05246
755178006141	Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951
755178006142	Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955
755178006143	Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418
755178006144	GSH binding site [chemical binding]; other site
755178006145	catalytic residues [active]
755178006146	Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605
755178006147	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
755178006148	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
755178006149	Peptidase family M48; Region: Peptidase_M48; pfam01435
755178006150	thiamine-phosphate pyrophosphorylase; Provisional; Region: PRK02615
755178006151	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
755178006152	thiamine phosphate binding site [chemical binding]; other site
755178006153	active site
755178006154	pyrophosphate binding site [ion binding]; other site
755178006155	UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511
755178006156	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
755178006157	putative metal binding site; other site
755178006158	Tetratricopeptide repeat; Region: TPR_16; pfam13432
755178006159	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
755178006160	binding surface
755178006161	TPR motif; other site
755178006162	TPR repeat; Region: TPR_11; pfam13414
755178006163	AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250
755178006164	feedback inhibition sensing region; other site
755178006165	homohexameric interface [polypeptide binding]; other site
755178006166	nucleotide binding site [chemical binding]; other site
755178006167	N-acetyl-L-glutamate binding site [chemical binding]; other site
755178006168	Predicted thiol-disulfide oxidoreductase [General function    prediction only]; Region: COG3011
755178006169	inosine 5-monophosphate dehydrogenase; Validated; Region: PRK08649
755178006170	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
755178006171	active site
755178006172	Alpha/beta hydrolase of unknown function (DUF1400); Region: DUF1400; pfam07176
755178006173	Uncharacterized protein conserved in bacteria (DUF2237); Region: DUF2237; pfam09996
755178006174	transferase 1, rSAM/selenodomain-associated; Region: glyco_like_cofC; TIGR04282
755178006175	adenylosuccinate lyase; Provisional; Region: PRK07380
755178006176	Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360
755178006177	tetramer interface [polypeptide binding]; other site
755178006178	active site
755178006179	Adenylosuccinate lyase C-terminus; Region: ADSL_C; smart00998
755178006180	molybdenum cofactor biosynthesis protein A, bacterial; Region: moaA; TIGR02666
755178006181	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
755178006182	FeS/SAM binding site; other site
755178006183	Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463
755178006184	Arsenate Reductase (ArsC) family; composed of TRX-fold arsenic reductases and similar proteins including the transcriptional regulator, Spx. ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], using reducing equivalents derived from...; Region: ArsC_family; cd02977
755178006185	ArsC family; Region: ArsC; pfam03960
755178006186	catalytic residue [active]
755178006187	PetN; Region: PetN; pfam03742
755178006188	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
755178006189	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
755178006190	HlyD family secretion protein; Region: HlyD_3; pfam13437
755178006191	Uncharacterized protein conserved in bacteria (DUF2062); Region: DUF2062; pfam09835
755178006192	hypothetical protein; Provisional; Region: PRK06850
755178006193	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
755178006194	Active Sites [active]
755178006195	Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413
755178006196	active site
755178006197	multimer interface [polypeptide binding]; other site
755178006198	Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009
755178006199	Family A polymerase primarily fills DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A; cl02626
755178006200	cyclophilin_TLP40_like: cyclophilin-type peptidylprolyl cis- trans isomerases (cyclophilins) similar ot the Spinach thylakoid lumen protein TLP40. Compared to the archetypal cyclophilin Human cyclophilin A, these proteins have similar peptidylprolyl...; Region: cyclophilin_TLP40_like; cd01924
755178006201	active site
755178006202	tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200
755178006203	Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724
755178006204	substrate binding site [chemical binding]; other site
755178006205	active site
755178006206	catalytic residues [active]
755178006207	heterodimer interface [polypeptide binding]; other site
755178006208	Protein of unknown function (DUF3007); Region: DUF3007; pfam11460
755178006209	NADH dehydrogenase transmembrane subunit; Region: NdhL; pfam10716
755178006210	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
755178006211	active site
755178006212	Fe-S-cluster-containing hydrogenase components 2 [Energy production and conversion]; Region: HycB; COG1142
755178006213	Iron-Sulfur binding protein C terminal; Region: LdpA_C; pfam12617
755178006214	YGGT family; Region: YGGT; pfam02325
755178006215	Transposase IS200 like; Region: Y1_Tnp; pfam01797
755178006216	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
755178006217	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
755178006218	Probable transposase; Region: OrfB_IS605; pfam01385
755178006219	ABC-type uncharacterized transport system; Region: ABC_transp_aux; pfam09822
755178006220	Oligosaccharyltransferase 48 kDa subunit beta; Region: DDOST_48kD; pfam03345
755178006221	bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627
755178006222	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
755178006223	active site
755178006224	Riboflavin kinase; Region: Flavokinase; pfam01687
755178006225	AbrB-like transcriptional regulator; Region: AbrB-like; pfam14250
755178006226	DNA damage checkpoint protein; Region: LCD1; pfam09798
755178006227	GrpE; Region: GrpE; pfam01025
755178006228	aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856
755178006229	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
755178006230	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
755178006231	pyridoxamine-phosphate oxidase; Region: pdxH; TIGR00558
755178006232	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
755178006233	Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590
755178006234	Phosphoketolase [Carbohydrate transport and metabolism]; Region: COG3957
755178006235	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629
755178006236	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568
755178006237	TPP-binding site [chemical binding]; other site
755178006238	Transketolase, pyrimidine binding domain; Region: Transket_pyr; smart00861
755178006239	Adenosine kinase (AK) catalyzes the phosphorylation of ribofuranosyl-containing nucleoside analogues at the 5'-hydroxyl using ATP or GTP as the phosphate donor.The physiological function of AK is associated with the regulation of extracellular...; Region: adenosine_kinase; cd01168
755178006240	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
755178006241	substrate binding site [chemical binding]; other site
755178006242	ATP binding site [chemical binding]; other site
755178006243	Cytochrome c; Region: Cytochrom_C; cl11414
755178006244	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
755178006245	MAPEG family; Region: MAPEG; pfam01124
755178006246	UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139
755178006247	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
755178006248	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
755178006249	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
755178006250	Predicted ATPase or kinase [General function prediction only]; Region: COG0802
755178006251	S23 ribosomal protein; Region: Ribosomal_S23p; pfam05635
755178006252	four helix bundle protein; Region: TIGR02436
755178006253	aspartate aminotransferase; Provisional; Region: PRK05942
755178006254	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
755178006255	pyridoxal 5'-phosphate binding site [chemical binding]; other site
755178006256	homodimer interface [polypeptide binding]; other site
755178006257	catalytic residue [active]
755178006258	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
755178006259	C-5 cytosine-specific DNA methylase; Region: DNA_methylase; pfam00145
755178006260	cofactor binding site; other site
755178006261	DNA binding site [nucleotide binding]
755178006262	substrate interaction site [chemical binding]; other site
755178006263	dimethylhistidine N-methyltransferase; Region: egtD_ergothio; TIGR03438
755178006264	Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017
755178006265	aspartate kinase; Provisional; Region: PRK07431
755178006266	AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261
755178006267	putative nucleotide binding site [chemical binding]; other site
755178006268	putative catalytic residues [active]
755178006269	putative Mg ion binding site [ion binding]; other site
755178006270	putative aspartate binding site [chemical binding]; other site
755178006271	ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913
755178006272	putative allosteric regulatory site; other site
755178006273	ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936
755178006274	ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913
755178006275	putative allosteric regulatory site; other site
755178006276	ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936
755178006277	putative allosteric regulatory residue; other site
755178006278	Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347
755178006279	Nitrogen regulatory protein P-II; Region: P-II; smart00938
755178006280	Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598
755178006281	Thermotoga maritima CorA_like subfamily; Region: TmCorA-like_1; cd12828
755178006282	oligomer interface [polypeptide binding]; other site
755178006283	metal binding site [ion binding]; metal-binding site
755178006284	metal binding site [ion binding]; metal-binding site
755178006285	Cl binding site [ion binding]; other site
755178006286	aspartate ring; other site
755178006287	basic sphincter; other site
755178006288	putative hydrophobic gate; other site
755178006289	periplasmic entrance; other site
755178006290	Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062
755178006291	class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300
755178006292	substrate binding site [chemical binding]; other site
755178006293	catalytic Zn binding site [ion binding]; other site
755178006294	NAD binding site [chemical binding]; other site
755178006295	structural Zn binding site [ion binding]; other site
755178006296	dimer interface [polypeptide binding]; other site
755178006297	CpcD/allophycocyanin linker domain; Region: CpcD; pfam01383
755178006298	Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427
755178006299	CpcD/allophycocyanin linker domain; Region: CpcD; pfam01383
755178006300	phycocyanin, alpha subunit; Region: phycocy_alpha; TIGR01338
755178006301	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
755178006302	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
755178006303	N-terminal plug; other site
755178006304	ligand-binding site [chemical binding]; other site
755178006305	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
755178006306	Fe3+-siderophore binding domain FhuD.  These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146
755178006307	siderophore binding site; other site
755178006308	Protein of unknown function (DUF1636); Region: DUF1636; pfam07845
755178006309	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
755178006310	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
755178006311	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
755178006312	putative glucosyl-3-phosphoglycerate synthase; Provisional; Region: PRK13915
755178006313	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
755178006314	cofactor binding site; other site
755178006315	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
755178006316	Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123
755178006317	Histone deacetylase class IV also known as histone deacetylase 11; Region: HDAC_classIV; cd09993
755178006318	putative active site [active]
755178006319	Zn binding site [ion binding]; other site
755178006320	Type II secretory pathway, pullulanase PulA and related glycosidases [Carbohydrate transport and metabolism]; Region: PulA; COG1523
755178006321	N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856
755178006322	Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326
755178006323	active site
755178006324	catalytic site [active]
755178006325	D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813
755178006326	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
755178006327	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
755178006328	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
755178006329	metal-binding site [ion binding]
755178006330	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
755178006331	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
755178006332	Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003
755178006333	active site
755178006334	hydrophilic channel; other site
755178006335	dimerization interface [polypeptide binding]; other site
755178006336	catalytic residues [active]
755178006337	active site lid [active]
755178006338	Protein of unknown function (DUF2488); Region: Ycf54; pfam10674
755178006339	anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585
755178006340	Uncharacterized conserved protein [Function unknown]; Region: COG1479
755178006341	Protein of unknown function DUF262; Region: DUF262; pfam03235
755178006342	Protein of unknown function (DUF1524); Region: DUF1524; pfam07510
755178006343	HEAT repeats; Region: HEAT_2; pfam13646
755178006344	HEAT repeats; Region: HEAT_2; pfam13646
755178006345	E-Z type HEAT repeats; Region: EZ_HEAT; smart00567
755178006346	FOG: CBS domain [General function prediction only]; Region: COG0517
755178006347	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205
755178006348	Protein of unknown function (DUF2808); Region: DUF2808; pfam10989
755178006349	5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812
755178006350	5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727
755178006351	RNA 2'-phosphotransferase; Reviewed; Region: PRK00819
755178006352	RNA:NAD 2'-phosphotransferase [Translation, ribosomal structure and biogenesis]; Region: KptA; COG1859
755178006353	Domain of unknown function (DUF4278); Region: DUF4278; pfam14105
755178006354	Domain of unknown function (DUF1824); Region: DUF1824; pfam08854
755178006355	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
755178006356	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
755178006357	Probable transposase; Region: OrfB_IS605; pfam01385
755178006358	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
755178006359	Piccolo Zn-finger; Region: zf-piccolo; pfam05715
755178006360	Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095
755178006361	HupE / UreJ protein; Region: HupE_UreJ; pfam04955
755178006362	Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553
755178006363	SNF2 Helicase protein; Region: DUF3670; pfam12419
755178006364	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
755178006365	ATP binding site [chemical binding]; other site
755178006366	putative Mg++ binding site [ion binding]; other site
755178006367	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
755178006368	nucleotide binding region [chemical binding]; other site
755178006369	ATP-binding site [chemical binding]; other site
755178006370	argininosuccinate synthase; Provisional; Region: PRK13820
755178006371	Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate .  In...; Region: Argininosuccinate_Synthase; cd01999
755178006372	ANP binding site [chemical binding]; other site
755178006373	Substrate Binding Site II [chemical binding]; other site
755178006374	Substrate Binding Site I [chemical binding]; other site
755178006375	recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409
755178006376	MutS domain III; Region: MutS_III; pfam05192
755178006377	ATP-binding cassette domain of MutS2; Region: ABC_MutS2; cd03280
755178006378	Walker A/P-loop; other site
755178006379	ATP binding site [chemical binding]; other site
755178006380	Q-loop/lid; other site
755178006381	ABC transporter signature motif; other site
755178006382	Walker B; other site
755178006383	D-loop; other site
755178006384	H-loop/switch region; other site
755178006385	Smr domain; Region: Smr; pfam01713
755178006386	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
755178006387	Catalytic domain of Protein Kinases; Region: PKc; cd00180
755178006388	active site
755178006389	ATP binding site [chemical binding]; other site
755178006390	substrate binding site [chemical binding]; other site
755178006391	activation loop (A-loop); other site
755178006392	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
755178006393	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
755178006394	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
755178006395	Ribonuclease III family protein [Replication, recombination, and    repair]; Region: COG1939
755178006396	dimerization interface [polypeptide binding]; other site
755178006397	active site
755178006398	metal binding site [ion binding]; metal-binding site
755178006399	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
755178006400	anti sigma factor interaction site; other site
755178006401	regulatory phosphorylation site [posttranslational modification]; other site
755178006402	RNA recognition motif; Region: RRM; smart00360
755178006403	Phycobilisome degradation protein nblA; Region: NblA; pfam04485
755178006404	Protein of unknown function (DUF3155); Region: DUF3155; pfam11352
755178006405	Lysyl-tRNA synthetase (class I) [Translation, ribosomal structure and biogenesis]; Region: LysS; COG1384
755178006406	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
755178006407	active site
755178006408	nucleotide binding site [chemical binding]; other site
755178006409	HIGH motif; other site
755178006410	KMSKS motif; other site
755178006411	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
755178006412	active site
755178006413	CpeT/CpcT family (DUF1001); Region: CpeT; pfam06206
755178006414	HEAT repeats; Region: HEAT_2; pfam13646
755178006415	HEAT repeats; Region: HEAT_2; pfam13646
755178006416	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
755178006417	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
755178006418	Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513
755178006419	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
755178006420	ATP binding site [chemical binding]; other site
755178006421	Mg++ binding site [ion binding]; other site
755178006422	motif III; other site
755178006423	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
755178006424	nucleotide binding region [chemical binding]; other site
755178006425	ATP-binding site [chemical binding]; other site
755178006426	ribosomal protein S12 methylthiotransferase RimO; Region: TIGR01125
755178006427	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
755178006428	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
755178006429	FeS/SAM binding site; other site
755178006430	Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009
755178006431	Stage II sporulation protein; Region: SpoIID; pfam08486
755178006432	SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669
755178006433	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
755178006434	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
755178006435	Uncharacterized protein conserved in bacteria (DUF2256); Region: DUF2256; pfam10013
755178006436	tRNA threonylcarbamoyl adenosine modification protein, Sua5/YciO/YrdC/YwlC family; Region: TIGR00057
755178006437	hypothetical protein; Provisional; Region: PRK04194
755178006438	formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027
755178006439	N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875
755178006440	Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648
755178006441	putative active site [active]
755178006442	putative substrate binding site [chemical binding]; other site
755178006443	putative cosubstrate binding site; other site
755178006444	catalytic site [active]
755178006445	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
755178006446	Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_like_2; cd08582
755178006447	putative active site [active]
755178006448	catalytic site [active]
755178006449	putative metal binding site [ion binding]; other site
755178006450	CobN/Magnesium Chelatase; Region: CobN-Mg_chel; pfam02514
755178006451	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
755178006452	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
755178006453	competence damage-inducible protein A; Provisional; Region: PRK00549
755178006454	Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885
755178006455	putative MPT binding site; other site
755178006456	Competence-damaged protein; Region: CinA; pfam02464
755178006457	Polysaccharide pyruvyl transferase family protein [Cell wall/membrane/envelope biogenesis]; Region: WcaK; COG2327
755178006458	polysaccharide pyruvyl transferase CsaB; Region: S_layer_CsaB; TIGR03609
755178006459	Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922
755178006460	The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533
755178006461	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
755178006462	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987
755178006463	putative acyl-acceptor binding pocket; other site
755178006464	radical SAM family uncharacterized protein; Region: rSAM_fuse_unch; TIGR03960
755178006465	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
755178006466	B12 binding site [chemical binding]; other site
755178006467	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
755178006468	B12 binding site [chemical binding]; other site
755178006469	Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729
755178006470	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377
755178006471	FeS/SAM binding site; other site
755178006472	Domain of unknown function (DUF4070); Region: DUF4070; pfam13282
755178006473	Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466
755178006474	Dehydroquinase class II; Region: DHquinase_II; pfam01220
755178006475	trimer interface [polypeptide binding]; other site
755178006476	active site
755178006477	dimer interface [polypeptide binding]; other site
755178006478	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
755178006479	L-threonine-O-3-phosphate decarboxylase; Region: L_thr_O3P_dcar; TIGR01140
755178006480	pyridoxal 5'-phosphate binding site [chemical binding]; other site
755178006481	homodimer interface [polypeptide binding]; other site
755178006482	catalytic residue [active]
755178006483	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
755178006484	IHF dimer interface [polypeptide binding]; other site
755178006485	IHF - DNA interface [nucleotide binding]; other site
755178006486	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2187
755178006487	Predicted kinase [General function prediction only]; Region: COG0645
755178006488	Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021
755178006489	ATP-binding site [chemical binding]; other site
755178006490	Gluconate-6-phosphate binding site [chemical binding]; other site
755178006491	D1, D2 subunits of photosystem II  (PSII); M, L subunits of bacterial photosynthetic reaction center; Region: Photo_RC; cl08220
755178006492	pheophytin binding site; other site
755178006493	chlorophyll binding site; other site
755178006494	quinone binding site; other site
755178006495	Fe binding site [ion binding]; other site
755178006496	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
755178006497	Probable transposase; Region: OrfB_IS605; pfam01385
755178006498	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
755178006499	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
755178006500	EpsO protein participates in the methanolan synthesis; Region: EpsO_like; cd06438
755178006501	DXD motif; other site
755178006502	prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532
755178006503	Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334
755178006504	TRAP-type mannitol/chloroaromatic compound transport system, small permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT2; COG4665
755178006505	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
755178006506	Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185
755178006507	putative acyl-acceptor binding pocket; other site
755178006508	Lipoate-protein ligase B [Coenzyme metabolism]; Region: LipB; COG0321
755178006509	putative monovalent cation/H+ antiporter subunit B; Reviewed; Region: PRK12567
755178006510	Domain of unknown function (DUF4040); Region: DUF4040; cl00676
755178006511	Na+/H+ antiporter subunit; Region: PhaG_MnhG_YufB; pfam03334
755178006512	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
755178006513	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
755178006514	ligand binding site [chemical binding]; other site
755178006515	flexible hinge region; other site
755178006516	The family 20 carbohydrate-binding module (CBM20), also known as the starch-binding domain, is found in a large number of starch degrading enzymes including alpha-amylase, beta-amylase, glucoamylase, and CGTase (cyclodextrin glucanotransferase). CBM20 is...; Region: CBM20; cd05467
755178006517	starch-binding site 2 [chemical binding]; other site
755178006518	starch-binding site 1 [chemical binding]; other site
755178006519	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229
755178006520	active site
755178006521	catalytic triad [active]
755178006522	oxyanion hole [active]
755178006523	Putative papain-like cysteine peptidase (DUF1796); Region: DUF1796; pfam08795
755178006524	threonine synthase; Validated; Region: PRK07591
755178006525	Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of  threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563
755178006526	homodimer interface [polypeptide binding]; other site
755178006527	pyridoxal 5'-phosphate binding site [chemical binding]; other site
755178006528	catalytic residue [active]
755178006529	Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754
755178006530	MoaE interaction surface [polypeptide binding]; other site
755178006531	MoeB interaction surface [polypeptide binding]; other site
755178006532	thiocarboxylated glycine; other site
755178006533	methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720
755178006534	S-methyl-5-thioribose-1-phosphate isomerase; Region: salvage_mtnA; TIGR00512
755178006535	Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544
755178006536	homotrimer interface [polypeptide binding]; other site
755178006537	Walker A motif; other site
755178006538	GTP binding site [chemical binding]; other site
755178006539	Walker B motif; other site
755178006540	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
755178006541	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
755178006542	dimer interface [polypeptide binding]; other site
755178006543	ssDNA binding site [nucleotide binding]; other site
755178006544	tetramer (dimer of dimers) interface [polypeptide binding]; other site
755178006545	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
755178006546	dimerization interface [polypeptide binding]; other site
755178006547	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
755178006548	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
755178006549	putative active site [active]
755178006550	heme pocket [chemical binding]; other site
755178006551	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
755178006552	dimer interface [polypeptide binding]; other site
755178006553	phosphorylation site [posttranslational modification]
755178006554	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
755178006555	ATP binding site [chemical binding]; other site
755178006556	Mg2+ binding site [ion binding]; other site
755178006557	G-X-G motif; other site
755178006558	Domain of unknown function (DUF4340); Region: DUF4340; pfam14238
755178006559	Metal-dependent hydrolases of the beta-lactamase superfamily II [General function prediction only]; Region: COG1237
755178006560	Uncharacterized protein family (UPF0104); Region: UPF0104; cl04219
755178006561	DNA directed RNA polymerase, 7 kDa subunit; Region: DNA_RNApol_7kD; cl00874
755178006562	Double zinc ribbon; Region: DZR; pfam12773
755178006563	Catalytic domain of EDTA-resistant nuclease Nuc, vertebrate phospholipase D6, and similar proteins; Region: PLDc_Nuc_like; cd09116
755178006564	PLD-like domain; Region: PLDc_2; pfam13091
755178006565	putative active site [active]
755178006566	catalytic site [active]
755178006567	Putative catalytic domain, repeat 2, of uncharacterized hypothetical proteins similar to Nuc, an endonuclease from Salmonella typhimurium; Region: PLDc_Nuc_like_unchar1_2; cd09173
755178006568	PLD-like domain; Region: PLDc_2; pfam13091
755178006569	putative active site [active]
755178006570	catalytic site [active]
755178006571	Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030
755178006572	Fe-S cluster binding site [ion binding]; other site
755178006573	active site
755178006574	phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619
755178006575	Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
755178006576	putative active site [active]
755178006577	catalytic triad [active]
755178006578	phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974
755178006579	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
755178006580	Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472
755178006581	Nickel-containing superoxide dismutase; Region: Sod_Ni; pfam09055
755178006582	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
755178006583	Catalytic site [active]
755178006584	chaperone protein DnaJ; Provisional; Region: PRK14293
755178006585	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
755178006586	HSP70 interaction site [polypeptide binding]; other site
755178006587	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
755178006588	Zn binding sites [ion binding]; other site
755178006589	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
755178006590	dimer interface [polypeptide binding]; other site
755178006591	SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain.  SirA (also known as UvrY,  and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291
755178006592	CPxP  motif; other site
755178006593	GTPase RsgA; Reviewed; Region: PRK12289
755178006594	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
755178006595	RNA binding site [nucleotide binding]; other site
755178006596	Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854
755178006597	GTPase/Zn-binding domain interface [polypeptide binding]; other site
755178006598	GTP/Mg2+ binding site [chemical binding]; other site
755178006599	G4 box; other site
755178006600	G5 box; other site
755178006601	G1 box; other site
755178006602	Switch I region; other site
755178006603	G2 box; other site
755178006604	G3 box; other site
755178006605	Switch II region; other site
755178006606	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
755178006607	putative active site [active]
755178006608	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
755178006609	active site
755178006610	DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012
755178006611	active site
755178006612	catalytic site [active]
755178006613	substrate binding site [chemical binding]; other site
755178006614	Predicted dehydrogenase [General function prediction only]; Region: COG0579
755178006615	hydroxyglutarate oxidase; Provisional; Region: PRK11728
755178006616	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
755178006617	Ligand Binding Site [chemical binding]; other site
755178006618	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
755178006619	Ligand Binding Site [chemical binding]; other site
755178006620	PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812
755178006621	putative active site [active]
755178006622	Predicted permeases [General function prediction only]; Region: COG0679
755178006623	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
755178006624	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
755178006625	Coenzyme A binding pocket [chemical binding]; other site
755178006626	Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130
755178006627	pseudouridine synthase; Region: TIGR00093
755178006628	active site
755178006629	Predicted membrane protein [Function unknown]; Region: COG3463
755178006630	Predicted membrane protein (DUF2079); Region: DUF2079; pfam09852
755178006631	agmatinase; Region: agmatinase; TIGR01230
755178006632	Agmatinase and related proteins; Region: Agmatinase-like_2; cd11593
755178006633	putative active site [active]
755178006634	Mn binding site [ion binding]; other site
755178006635	PBP superfamily domain; Region: PBP_like_2; cl17296
755178006636	Phosphotransferase enzyme family; Region: APH; pfam01636
755178006637	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
755178006638	active site
755178006639	ATP binding site [chemical binding]; other site
755178006640	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
755178006641	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
755178006642	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
755178006643	Walker A/P-loop; other site
755178006644	ATP binding site [chemical binding]; other site
755178006645	Q-loop/lid; other site
755178006646	ABC transporter signature motif; other site
755178006647	Walker B; other site
755178006648	D-loop; other site
755178006649	H-loop/switch region; other site
755178006650	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
755178006651	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
755178006652	This is a family of GT1 glycosyltransferases found specifically in certain bacteria. amsK in Erwinia amylovora, has been reported to be involved in the biosynthesis of amylovoran, a exopolysaccharide acting as a virulence factor; Region: GT1_amsK_like; cd03799
755178006653	colanic acid biosynthesis glycosyltransferase WcaL; Provisional; Region: PRK15427
755178006654	putative ADP-binding pocket [chemical binding]; other site
755178006655	S23 ribosomal protein; Region: Ribosomal_S23p; pfam05635
755178006656	four helix bundle protein; Region: TIGR02436
755178006657	K+-transporting ATPase, c chain; Region: KdpC; cl00944
755178006658	F subunit of K+-transporting ATPase (Potass_KdpF); Region: Potass_KdpF; pfam09604
755178006659	potassium-transporting ATPase subunit B; Provisional; Region: PRK01122
755178006660	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
755178006661	Soluble P-type ATPase [General function prediction only]; Region: COG4087
755178006662	potassium-transporting ATPase subunit A; Provisional; Region: PRK05482
755178006663	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
755178006664	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
755178006665	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
755178006666	dimer interface [polypeptide binding]; other site
755178006667	phosphorylation site [posttranslational modification]
755178006668	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
755178006669	ATP binding site [chemical binding]; other site
755178006670	Mg2+ binding site [ion binding]; other site
755178006671	G-X-G motif; other site
755178006672	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
755178006673	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
755178006674	active site
755178006675	phosphorylation site [posttranslational modification]
755178006676	intermolecular recognition site; other site
755178006677	dimerization interface [polypeptide binding]; other site
755178006678	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
755178006679	DNA binding residues [nucleotide binding]
755178006680	dimerization interface [polypeptide binding]; other site
755178006681	Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702
755178006682	USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987
755178006683	Ligand Binding Site [chemical binding]; other site
755178006684	isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641
755178006685	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
755178006686	substrate binding site [chemical binding]; other site
755178006687	Amino acid permease; Region: AA_permease; pfam00324
755178006688	9,9'-di-cis-zeta-carotene desaturase; Region: zeta_caro_desat; TIGR02732
755178006689	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
755178006690	Streptococcal 67 kDa myosin-cross-reactive antigen like family; Region: Strep_67kDa_ant; cl17487
755178006691	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
755178006692	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
755178006693	dimer interface [polypeptide binding]; other site
755178006694	putative functional site; other site
755178006695	putative MPT binding site; other site
755178006696	aspartate aminotransferase; Provisional; Region: PRK05764
755178006697	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
755178006698	pyridoxal 5'-phosphate binding site [chemical binding]; other site
755178006699	homodimer interface [polypeptide binding]; other site
755178006700	catalytic residue [active]
755178006701	Predicted Fe-S-cluster oxidoreductase [General function prediction only]; Region: COG0727
755178006702	Photosystem II complex subunit Ycf12; Region: PSII_Ycf12; cl12139
755178006703	4-alpha-glucanotransferase; Provisional; Region: PRK14508
755178006704	Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286
755178006705	catalytic motif [active]
755178006706	Zn binding site [ion binding]; other site
755178006707	Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116
755178006708	RuvA N terminal domain; Region: RuvA_N; pfam01330
755178006709	RuvA, C-terminal domain; Region: RuvA_C; pfam07499
755178006710	Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194
755178006711	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
755178006712	catalytic site [active]
755178006713	G-X2-G-X-G-K; other site
755178006714	Uncharacterized conserved protein [Function unknown]; Region: COG1624
755178006715	DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457
755178006716	putative nicotinate phosphoribosyltransferase; Provisional; Region: PRK09198
755178006717	pre-B-cell colony-enhancing factor (PBEF)-like. The mammalian members of this group of nicotinate phosphoribosyltransferases (NAPRTases) were originally identified as genes whose expression is upregulated upon activation in lymphoid cells. In general; Region: PBEF_like; cd01569
755178006718	active site
755178006719	Phosphoribosylpyrophosphate synthetase [Nucleotide transport and metabolism / Amino acid transport and metabolism]; Region: PrsA; COG0462
755178006720	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
755178006721	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
755178006722	active site
755178006723	Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138
755178006724	Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416
755178006725	putative active site [active]
755178006726	Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414
755178006727	putative active site [active]
755178006728	Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557
755178006729	oligomerization interface [polypeptide binding]; other site
755178006730	active site
755178006731	metal binding site [ion binding]; metal-binding site
755178006732	Protein of unknown function (DUF98); Region: DUF98; pfam01947
755178006733	Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217
755178006734	Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891
755178006735	G1 box; other site
755178006736	putative GEF interaction site [polypeptide binding]; other site
755178006737	GTP/Mg2+ binding site [chemical binding]; other site
755178006738	Switch I region; other site
755178006739	G2 box; other site
755178006740	G3 box; other site
755178006741	Switch II region; other site
755178006742	G4 box; other site
755178006743	G5 box; other site
755178006744	BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu.  BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691
755178006745	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a highly...; Region: BipA_TypA_C; cd03710
755178006746	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
755178006747	putative active site [active]
755178006748	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
755178006749	Catalytic domain of Protein Kinases; Region: PKc; cd00180
755178006750	active site
755178006751	ATP binding site [chemical binding]; other site
755178006752	substrate binding site [chemical binding]; other site
755178006753	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
755178006754	substrate binding site [chemical binding]; other site
755178006755	activation loop (A-loop); other site
755178006756	activation loop (A-loop); other site
755178006757	Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049
755178006758	dimer interface [polypeptide binding]; other site
755178006759	ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966
755178006760	putative radical transfer pathway; other site
755178006761	diiron center [ion binding]; other site
755178006762	tyrosyl radical; other site
755178006763	Protein of unknown function (DUF3365); Region: DUF3365; pfam11845
755178006764	homoserine kinase; Provisional; Region: PRK01212
755178006765	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
755178006766	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
755178006767	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
755178006768	phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647
755178006769	Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645
755178006770	active site
755178006771	substrate binding site [chemical binding]; other site
755178006772	cosubstrate binding site; other site
755178006773	catalytic site [active]
755178006774	Domain of unknown function DUF20; Region: UPF0118; pfam01594
755178006775	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
755178006776	hypothetical protein; Provisional; Region: PRK02509
755178006777	Uncharacterized conserved protein [Function unknown]; Region: COG1615
755178006778	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
755178006779	active site
755178006780	Alanine-glyoxylate aminotransferase (AGAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to alanine-glyoxylate aminotransferase (AGAT); Region: AGAT_like; cd06451
755178006781	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
755178006782	homodimer interface [polypeptide binding]; other site
755178006783	pyridoxal 5'-phosphate binding site [chemical binding]; other site
755178006784	catalytic residue [active]
755178006785	RNA polymerase sigma factor SigD; Validated; Region: PRK07405
755178006786	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
755178006787	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
755178006788	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
755178006789	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
755178006790	DNA binding residues [nucleotide binding]
755178006791	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
755178006792	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
755178006793	ABC exporter membrane fusion protein, DevB family; Region: heterocyst_DevB; TIGR02971
755178006794	HlyD family secretion protein; Region: HlyD_3; pfam13437
755178006795	DevC protein; Region: devC; TIGR01185
755178006796	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
755178006797	FtsX-like permease family; Region: FtsX; pfam02687
755178006798	glycine dehydrogenase; Provisional; Region: PRK05367
755178006799	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
755178006800	tetramer interface [polypeptide binding]; other site
755178006801	pyridoxal 5'-phosphate binding site [chemical binding]; other site
755178006802	catalytic residue [active]
755178006803	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
755178006804	tetramer interface [polypeptide binding]; other site
755178006805	pyridoxal 5'-phosphate binding site [chemical binding]; other site
755178006806	catalytic residue [active]
755178006807	Domain of unknown function (DUF4351); Region: DUF4351; pfam14261
755178006808	aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381
755178006809	Bacillus subtilis aldehyde dehydrogenase ywdH-like; Region: ALDH_YwdH-P39616; cd07136
755178006810	NAD(P) binding site [chemical binding]; other site
755178006811	catalytic residues [active]
755178006812	Methyltransferase domain; Region: Methyltransf_26; pfam13659
755178006813	Domain of unknown function, appears to be related to a diverse group of endonucleases; Region: Endonuclease_DUF559; cd01038
755178006814	putative active site [active]
755178006815	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
755178006816	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
755178006817	[2Fe-2S] cluster binding site [ion binding]; other site
755178006818	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
755178006819	Major Facilitator Superfamily; Region: MFS_1; pfam07690
755178006820	putative substrate translocation pore; other site
755178006821	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
755178006822	G1 box; other site
755178006823	GTP/Mg2+ binding site [chemical binding]; other site
755178006824	G2 box; other site
755178006825	Switch I region; other site
755178006826	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
755178006827	G3 box; other site
755178006828	Switch II region; other site
755178006829	G4 box; other site
755178006830	KGK domain; Region: KGK; pfam08872
755178006831	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
755178006832	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
755178006833	active site
755178006834	The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425
755178006835	active site
755178006836	8-oxo-dGMP binding site [chemical binding]; other site
755178006837	nudix motif; other site
755178006838	metal binding site [ion binding]; metal-binding site
755178006839	signal recognition particle protein; Provisional; Region: PRK10867
755178006840	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
755178006841	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
755178006842	GTP binding site [chemical binding]; other site
755178006843	Signal peptide binding domain; Region: SRP_SPB; pfam02978
755178006844	30S ribosomal protein S1; Reviewed; Region: PRK07400
755178006845	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
755178006846	RNA binding site [nucleotide binding]; other site
755178006847	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
755178006848	RNA binding site [nucleotide binding]; other site
755178006849	S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688
755178006850	RNA binding site [nucleotide binding]; other site
755178006851	transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464
755178006852	ATP cone domain; Region: ATP-cone; pfam03477
755178006853	photosystem II reaction center protein T; Reviewed; Region: psbT; PRK11875
755178006854	photosystem II 47 kDa protein; Region: psbB; CHL00062
755178006855	Domain of unknown function (DUF4332); Region: DUF4332; pfam14229
755178006856	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
755178006857	PAS domain; Region: PAS_9; pfam13426
755178006858	putative active site [active]
755178006859	heme pocket [chemical binding]; other site
755178006860	GAF domain; Region: GAF; pfam01590
755178006861	GAF domain; Region: GAF_2; pfam13185
755178006862	GAF domain; Region: GAF; pfam01590
755178006863	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
755178006864	GAF domain; Region: GAF; pfam01590
755178006865	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
755178006866	dimer interface [polypeptide binding]; other site
755178006867	phosphorylation site [posttranslational modification]
755178006868	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
755178006869	ATP binding site [chemical binding]; other site
755178006870	Mg2+ binding site [ion binding]; other site
755178006871	G-X-G motif; other site
755178006872	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
755178006873	Response regulator receiver domain; Region: Response_reg; pfam00072
755178006874	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
755178006875	active site
755178006876	phosphorylation site [posttranslational modification]
755178006877	intermolecular recognition site; other site
755178006878	dimerization interface [polypeptide binding]; other site
755178006879	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
755178006880	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
755178006881	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
755178006882	S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476
755178006883	S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401
755178006884	homotetramer interface [polypeptide binding]; other site
755178006885	ligand binding site [chemical binding]; other site
755178006886	catalytic site [active]
755178006887	NAD binding site [chemical binding]; other site
755178006888	Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833
755178006889	Domain of unknown function (DUF814); Region: DUF814; pfam05670
755178006890	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
755178006891	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
755178006892	active site
755178006893	phosphorylation site [posttranslational modification]
755178006894	intermolecular recognition site; other site
755178006895	dimerization interface [polypeptide binding]; other site
755178006896	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
755178006897	DNA binding site [nucleotide binding]
755178006898	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
755178006899	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
755178006900	active site
755178006901	Cytochrome B6-F complex subunit 5; Region: PetG; cl03637
755178006902	deoxyribodipyrimidine photo-lyase, 8-HDF type; Region: photolyase_8HDF; TIGR03556
755178006903	DNA photolyase; Region: DNA_photolyase; pfam00875
755178006904	Domain of unknown function (DUF4114); Region: DUF4114; pfam13448
755178006905	exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025
755178006906	Bacterial sugar transferase; Region: Bac_transf; pfam02397
755178006907	lysozyme_like domain.  This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222
755178006908	catalytic residue [active]
755178006909	Plasmid encoded toxin Txe; Region: Plasmid_Txe; cl17389
755178006910	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604
755178006911	GTPase SAR1 and related small G proteins [General function prediction only]; Region: COG1100
755178006912	E. coli Ras-like protein (Era)-like GTPase; Region: Era_like; cd00880
755178006913	G1 box; other site
755178006914	GTP/Mg2+ binding site [chemical binding]; other site
755178006915	Switch I region; other site
755178006916	G2 box; other site
755178006917	Switch II region; other site
755178006918	G3 box; other site
755178006919	G4 box; other site
755178006920	G5 box; other site
755178006921	Domain of unknown function (DUF697); Region: DUF697; pfam05128
755178006922	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
755178006923	cation diffusion facilitator family transporter; Region: CDF; TIGR01297
755178006924	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
755178006925	AAA domain; Region: AAA_23; pfam13476
755178006926	Walker A/P-loop; other site
755178006927	ATP binding site [chemical binding]; other site
755178006928	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
755178006929	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
755178006930	Probable transposase; Region: OrfB_IS605; pfam01385
755178006931	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
755178006932	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
755178006933	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
755178006934	ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163
755178006935	substrate binding site [chemical binding]; other site
755178006936	hexamer interface [polypeptide binding]; other site
755178006937	metal binding site [ion binding]; metal-binding site
755178006938	Predicted phosphatase [General function prediction only]; Region: PhoX; COG3211
755178006939	Circadian oscillating protein COP23; Region: COP23; pfam14218
755178006940	Circadian oscillating protein COP23; Region: COP23; pfam14218
755178006941	serine/threonine-protein kinase 1; Provisional; Region: pk1; PHA03390
755178006942	Catalytic domain of Protein Kinases; Region: PKc; cd00180
755178006943	active site
755178006944	ATP binding site [chemical binding]; other site
755178006945	substrate binding site [chemical binding]; other site
755178006946	activation loop (A-loop); other site
755178006947	Circadian oscillating protein COP23; Region: COP23; pfam14218
755178006948	Uncharacterized protein containing caspase domain [General function prediction only]; Region: COG4249
755178006949	Caspase domain; Region: Peptidase_C14; pfam00656
755178006950	substrate pocket [chemical binding]; other site
755178006951	active site
755178006952	dimer interface [polypeptide binding]; other site
755178006953	proteolytic cleavage site; other site
755178006954	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
755178006955	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
755178006956	dimer interface [polypeptide binding]; other site
755178006957	conserved gate region; other site
755178006958	putative PBP binding loops; other site
755178006959	ABC-ATPase subunit interface; other site
755178006960	Exoribonuclease R [Transcription]; Region: VacB; COG0557
755178006961	Ribonuclease B OB domain; Region: OB_RNB; pfam08206
755178006962	RNB domain; Region: RNB; pfam00773
755178006963	S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471
755178006964	RNA binding site [nucleotide binding]; other site
755178006965	glycosyltransferase, TIGR04182 family; Region: glyco_TIGR04182
755178006966	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
755178006967	Ligand binding site; other site
755178006968	Putative Catalytic site; other site
755178006969	DXD motif; other site
755178006970	Transposase IS200 like; Region: Y1_Tnp; cl00848
755178006971	Domain of unknown function (DUF4415); Region: DUF4415; pfam14384
755178006972	Protein of unknown function (DUF497); Region: DUF497; pfam04365
755178006973	5-methyltetrahydrofolate--homocysteine methyltransferase; Region: metH; TIGR02082
755178006974	Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646
755178006975	MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH).  Cobalamin-dependent...; Region: MeTr; cd00740
755178006976	substrate binding pocket [chemical binding]; other site
755178006977	B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069
755178006978	B12 binding site [chemical binding]; other site
755178006979	cobalt ligand [ion binding]; other site
755178006980	Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965
755178006981	Methyltransferase domain; Region: Methyltransf_31; pfam13847
755178006982	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
755178006983	S-adenosylmethionine binding site [chemical binding]; other site
755178006984	YcfA-like protein; Region: YcfA; pfam07927
755178006985	Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681
755178006986	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
755178006987	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
755178006988	Alpha amylase catalytic domain found in sucrose phosphorylase-like proteins (also called sucrose glucosyltransferase, disaccharide glucosyltransferase, and sucrose-phosphate alpha-D glucosyltransferase); Region: AmyAc_Sucrose_phosphorylase-like_1; cd11356
755178006989	sucrose phosphorylase; Provisional; Region: PRK13840
755178006990	active site
755178006991	homodimer interface [polypeptide binding]; other site
755178006992	catalytic site [active]
755178006993	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884
755178006994	active site clefts [active]
755178006995	zinc binding site [ion binding]; other site
755178006996	dimer interface [polypeptide binding]; other site
755178006997	Hypothetical chloroplast protein Ycf34; Region: Ycf34; pfam10718
755178006998	Protein of unknown function (DUF3370); Region: DUF3370; pfam11850
755178006999	Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137
755178007000	dimer interface [polypeptide binding]; other site
755178007001	FMN binding site [chemical binding]; other site
755178007002	Pirin-related protein [General function prediction only]; Region: COG1741
755178007003	Pirin; Region: Pirin; pfam02678
755178007004	Transcriptional regulator [Transcription]; Region: LysR; COG0583
755178007005	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
755178007006	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
755178007007	putative effector binding pocket; other site
755178007008	dimerization interface [polypeptide binding]; other site
755178007009	Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099
755178007010	cobalt-precorrin-6x reductase; Reviewed; Region: PRK08057
755178007011	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
755178007012	dimerization interface [polypeptide binding]; other site
755178007013	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
755178007014	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
755178007015	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
755178007016	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
755178007017	HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304
755178007018	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
755178007019	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
755178007020	dimer interface [polypeptide binding]; other site
755178007021	putative CheW interface [polypeptide binding]; other site
755178007022	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
755178007023	dimerization interface [polypeptide binding]; other site
755178007024	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
755178007025	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
755178007026	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
755178007027	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
755178007028	HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304
755178007029	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
755178007030	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
755178007031	dimer interface [polypeptide binding]; other site
755178007032	putative CheW interface [polypeptide binding]; other site
755178007033	Protein of unknown function (DUF3120); Region: DUF3120; pfam11318
755178007034	Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055
755178007035	Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the...; Region: P_permease; cd01116
755178007036	transmembrane helices; other site
755178007037	Domain of unknown function (DUF1704); Region: DUF1704; cl06858
755178007038	Alpha/beta hydrolase of unknown function (DUF1400); Region: DUF1400; pfam07176
755178007039	Predicted dienelactone hydrolase [General function prediction only]; Region: COG4188
755178007040	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
755178007041	putative active site [active]
755178007042	transcription termination factor Rho; Provisional; Region: PRK12678
755178007043	Predicted periplasmic protein (DUF2092); Region: DUF2092; pfam09865
755178007044	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465
755178007045	S-layer homology domain; Region: SLH; pfam00395
755178007046	S-layer homology domain; Region: SLH; pfam00395
755178007047	Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625
755178007048	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
755178007049	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
755178007050	FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659
755178007051	coproporphyrinogen III oxidase; Provisional; Region: PRK05330
755178007052	Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218
755178007053	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
755178007054	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
755178007055	Walker A/P-loop; other site
755178007056	ATP binding site [chemical binding]; other site
755178007057	Q-loop/lid; other site
755178007058	ABC transporter signature motif; other site
755178007059	Walker B; other site
755178007060	D-loop; other site
755178007061	H-loop/switch region; other site
755178007062	hypothetical protein; Validated; Region: PRK01415
755178007063	Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518
755178007064	active site residue [active]
755178007065	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
755178007066	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
755178007067	catalytic triad [active]
755178007068	Uncharacterized conserved protein [Function unknown]; Region: COG1432
755178007069	NYN domain; Region: NYN; pfam01936
755178007070	putative metal binding site [ion binding]; other site
755178007071	Photosystem I psaA/psaB protein; Region: PsaA_PsaB; cl08224
755178007072	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
755178007073	HSP70 interaction site [polypeptide binding]; other site
755178007074	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
755178007075	Probable transposase; Region: OrfB_IS605; pfam01385
755178007076	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
755178007077	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419
755178007078	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
755178007079	Walker A/P-loop; other site
755178007080	ATP binding site [chemical binding]; other site
755178007081	Q-loop/lid; other site
755178007082	ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279
755178007083	ABC transporter signature motif; other site
755178007084	Walker B; other site
755178007085	D-loop; other site
755178007086	H-loop/switch region; other site
755178007087	putative succinate semialdehyde dehydrogenase; Provisional; Region: PRK13968
755178007088	Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100
755178007089	NAD(P) binding site [chemical binding]; other site
755178007090	catalytic residues [active]
755178007091	Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123
755178007092	Histone deacetylases and histone-like deacetylases, classII; Region: HDAC_classII; cd09992
755178007093	active site
755178007094	Zn binding site [ion binding]; other site
755178007095	Protein of unknown function (DUF3352); Region: DUF3352; pfam11832
755178007096	Membrane-bound lytic murein transglycosylase [Cell envelope biogenesis, outer membrane]; Region: MltA; COG2821
755178007097	MltA specific insert domain; Region: MltA; pfam03562
755178007098	3D domain; Region: 3D; pfam06725
755178007099	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
755178007100	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
755178007101	GIY-YIG domain found in CAXIP1-like proteins, iron-sulfur cluster assembly proteins, and similar proteins; Region: GIY-YIG_AtGrxS16_like; cd10450
755178007102	GIY-YIG motif/motif A; other site
755178007103	Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125
755178007104	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
755178007105	TMP-binding site; other site
755178007106	ATP-binding site [chemical binding]; other site
755178007107	Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249
755178007108	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
755178007109	D1 subunit  of photosystem II (PS II); Region: Photosystem-II_D1; cd09289
755178007110	protein I interface; other site
755178007111	D2 interface; other site
755178007112	protein T interface; other site
755178007113	chlorophyll binding site; other site
755178007114	beta carotene binding site; other site
755178007115	pheophytin binding site; other site
755178007116	manganese-stabilizing polypeptide interface; other site
755178007117	CP43 interface; other site
755178007118	protein L interface; other site
755178007119	oxygen evolving complex binding site; other site
755178007120	bromide binding site; other site
755178007121	quinone binding site; other site
755178007122	Fe binding site [ion binding]; other site
755178007123	core light harvesting interface; other site
755178007124	cytochrome b559 alpha subunit interface; other site
755178007125	cytochrome c-550 interface; other site
755178007126	protein J interface; other site
755178007127	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
755178007128	putative active site [active]
755178007129	HEAT repeats; Region: HEAT_2; pfam13646
755178007130	HEAT repeats; Region: HEAT_2; pfam13646
755178007131	Dynamin family; Region: Dynamin_N; pfam00350
755178007132	phosphate transporter ATP-binding protein; Provisional; Region: PRK14243
755178007133	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
755178007134	Walker A/P-loop; other site
755178007135	ATP binding site [chemical binding]; other site
755178007136	Q-loop/lid; other site
755178007137	ABC transporter signature motif; other site
755178007138	Walker B; other site
755178007139	D-loop; other site
755178007140	H-loop/switch region; other site
755178007141	phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974
755178007142	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
755178007143	dimer interface [polypeptide binding]; other site
755178007144	conserved gate region; other site
755178007145	putative PBP binding loops; other site
755178007146	ABC-ATPase subunit interface; other site
755178007147	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573
755178007148	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
755178007149	dimer interface [polypeptide binding]; other site
755178007150	conserved gate region; other site
755178007151	putative PBP binding loops; other site
755178007152	ABC-ATPase subunit interface; other site
755178007153	PBP superfamily domain; Region: PBP_like_2; cl17296
755178007154	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
755178007155	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
755178007156	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
755178007157	catalytic residue [active]
755178007158	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
755178007159	M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886
755178007160	metal binding site [ion binding]; metal-binding site
755178007161	dimer interface [polypeptide binding]; other site
755178007162	Clp protease; Region: CLP_protease; pfam00574
755178007163	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
755178007164	oligomer interface [polypeptide binding]; other site
755178007165	active site residues [active]
755178007166	Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; pfam02660
755178007167	phosphoenolpyruvate synthase; Validated; Region: PRK06241
755178007168	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
755178007169	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
755178007170	cobalamin synthase; Reviewed; Region: cobS; PRK00235
755178007171	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
755178007172	dimerization interface [polypeptide binding]; other site
755178007173	putative DNA binding site [nucleotide binding]; other site
755178007174	putative Zn2+ binding site [ion binding]; other site
755178007175	Protein of unknown function (DUF3134); Region: DUF3134; pfam11332
755178007176	PAP_fibrillin; Region: PAP_fibrillin; pfam04755
755178007177	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
755178007178	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
755178007179	catalytic loop [active]
755178007180	iron binding site [ion binding]; other site
755178007181	Protein of unknown function (DUF2996); Region: DUF2996; pfam11210
755178007182	Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572
755178007183	histidinol dehydrogenase; Region: hisD; TIGR00069
755178007184	NAD binding site [chemical binding]; other site
755178007185	dimerization interface [polypeptide binding]; other site
755178007186	product binding site; other site
755178007187	substrate binding site [chemical binding]; other site
755178007188	zinc binding site [ion binding]; other site
755178007189	catalytic residues [active]
755178007190	Fe-S oxidoreductase [Energy production and conversion]; Region: COG1032
755178007191	B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068
755178007192	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
755178007193	FeS/SAM binding site; other site
755178007194	Domain of unknown function (DUF4070); Region: DUF4070; pfam13282
755178007195	C factor cell-cell signaling protein; Provisional; Region: PRK09009
755178007196	carbonyl reductase sniffer-like, classical (c) SDRs; Region: carb_red_sniffer_like_SDR_c; cd05325
755178007197	NADP binding site [chemical binding]; other site
755178007198	homodimer interface [polypeptide binding]; other site
755178007199	active site
755178007200	imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141
755178007201	Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748
755178007202	putative active site [active]
755178007203	oxyanion strand; other site
755178007204	catalytic triad [active]
755178007205	This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300
755178007206	homodimer interface [polypeptide binding]; other site
755178007207	glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093
755178007208	active site pocket [active]
755178007209	Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501
755178007210	16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713
755178007211	RNA methyltransferase, RsmE family; Region: TIGR00046
755178007212	Mg-protoporphyrin IX methyl transferase; Validated; Region: PRK07580
755178007213	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
755178007214	S-adenosylmethionine binding site [chemical binding]; other site
755178007215	Magnesium-protoporphyrin IX methyltransferase C-terminus; Region: Mg-por_mtran_C; pfam07109
755178007216	Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304
755178007217	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
755178007218	metal ion-dependent adhesion site (MIDAS); other site
755178007219	Mth938-like domain. The members of this family include: Mth938, 2P1, Xcr35, Rpa2829, and several uncharacterized sequences. Mth938 is a hypothetical protein encoded by the Methanobacterium thermoautotrophicum (Mth) genome. This protein crystallizes as a...; Region: Mth938-like; cl00182
755178007220	Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270
755178007221	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
755178007222	cofactor binding site; other site
755178007223	DNA binding site [nucleotide binding]
755178007224	substrate interaction site [chemical binding]; other site
755178007225	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
755178007226	RNA polymerase sigma factor SigF; Reviewed; Region: PRK07408
755178007227	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
755178007228	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
755178007229	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
755178007230	DNA binding residues [nucleotide binding]
755178007231	Methyltransferase domain; Region: Methyltransf_23; pfam13489
755178007232	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
755178007233	S-adenosylmethionine binding site [chemical binding]; other site
755178007234	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
755178007235	D-xylulose kinase; Region: XylB; TIGR01312
755178007236	nucleotide binding site [chemical binding]; other site
755178007237	hypothetical protein; Validated; Region: PRK07411
755178007238	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
755178007239	ATP binding site [chemical binding]; other site
755178007240	substrate interface [chemical binding]; other site
755178007241	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
755178007242	active site residue [active]
755178007243	RNA polymerase sigma factor; Validated; Region: PRK05949
755178007244	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
755178007245	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
755178007246	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
755178007247	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
755178007248	DNA binding residues [nucleotide binding]
755178007249	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
755178007250	Amidase; Region: Amidase; pfam01425
755178007251	putative protein serine/threonine phosphatase; Provisional; Region: PRK14559
755178007252	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
755178007253	active site
755178007254	putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347
755178007255	PAS domain; Region: PAS_9; pfam13426
755178007256	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
755178007257	putative active site [active]
755178007258	heme pocket [chemical binding]; other site
755178007259	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
755178007260	PAS fold; Region: PAS_3; pfam08447
755178007261	putative active site [active]
755178007262	heme pocket [chemical binding]; other site
755178007263	PAS domain S-box; Region: sensory_box; TIGR00229
755178007264	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
755178007265	putative active site [active]
755178007266	heme pocket [chemical binding]; other site
755178007267	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
755178007268	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
755178007269	metal binding site [ion binding]; metal-binding site
755178007270	active site
755178007271	I-site; other site
755178007272	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
755178007273	CHAT domain; Region: CHAT; cl17868
755178007274	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
755178007275	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
755178007276	Walker A/P-loop; other site
755178007277	ATP binding site [chemical binding]; other site
755178007278	Q-loop/lid; other site
755178007279	ABC transporter signature motif; other site
755178007280	Walker B; other site
755178007281	D-loop; other site
755178007282	H-loop/switch region; other site
755178007283	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
755178007284	active site
755178007285	SAM binding site [chemical binding]; other site
755178007286	homodimer interface [polypeptide binding]; other site
755178007287	MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886
755178007288	MPT binding site; other site
755178007289	trimer interface [polypeptide binding]; other site
755178007290	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
755178007291	Coenzyme A binding pocket [chemical binding]; other site
755178007292	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_2; pfam13532
755178007293	transaldolase/EF-hand domain-containing protein; Provisional; Region: PRK12309
755178007294	Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957
755178007295	active site
755178007296	dimer interface [polypeptide binding]; other site
755178007297	catalytic residue [active]
755178007298	EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cd00051
755178007299	Ca2+ binding site [ion binding]; other site
755178007300	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
755178007301	adenosylmethionine--8-amino-7-oxononanoate transaminase; Validated; Region: PRK07986
755178007302	inhibitor-cofactor binding pocket; inhibition site
755178007303	pyridoxal 5'-phosphate binding site [chemical binding]; other site
755178007304	catalytic residue [active]
755178007305	MreB/Mbl protein; Region: MreB_Mbl; pfam06723
755178007306	Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170
755178007307	nucleotide binding site [chemical binding]; other site
755178007308	putative NEF/HSP70 interaction site [polypeptide binding]; other site
755178007309	SBD interface [polypeptide binding]; other site
755178007310	Putative transcriptional regulators (Ypuh-like); Region: DUF387; cl00612
755178007311	DNA polymerase I; Reviewed; Region: PRK05761
755178007312	NCAIR mutase (PurE)-related proteins [General function prediction only]; Region: COG1691
755178007313	AIR carboxylase; Region: AIRC; smart01001
755178007314	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
755178007315	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
755178007316	putative active site [active]
755178007317	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
755178007318	metal ion-dependent adhesion site (MIDAS); other site
755178007319	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
755178007320	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
755178007321	TM-ABC transporter signature motif; other site
755178007322	Protein of unknown function, DUF488; Region: DUF488; pfam04343
755178007323	Protein of unknown function, DUF488; Region: DUF488; pfam04343
755178007324	Uncharacterized conserved protein [Function unknown]; Region: COG2433
755178007325	Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196
755178007326	GTPase subunit of restriction endonuclease [Defense mechanisms]; Region: McrB; COG1401
755178007327	Part of AAA domain; Region: AAA_19; pfam13245
755178007328	AAA domain; Region: AAA_11; pfam13086
755178007329	AAA domain; Region: AAA_12; pfam13087
755178007330	Protein kinase domain; Region: Pkinase; pfam00069
755178007331	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
755178007332	active site
755178007333	ATP binding site [chemical binding]; other site
755178007334	substrate binding site [chemical binding]; other site
755178007335	activation loop (A-loop); other site
755178007336	Protein phosphatase 2C; Region: PP2C_2; pfam13672
755178007337	active site
755178007338	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
755178007339	metal ion-dependent adhesion site (MIDAS); other site
755178007340	HEAT repeats; Region: HEAT_2; pfam13646
755178007341	HEAT repeats; Region: HEAT_2; pfam13646
755178007342	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
755178007343	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
755178007344	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
755178007345	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
755178007346	Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416
755178007347	Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138
755178007348	putative active site [active]
755178007349	Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414
755178007350	putative active site [active]
755178007351	Permease SLC13 (solute carrier 13).  The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115
755178007352	transmembrane helices; other site
755178007353	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
755178007354	TrkA-C domain; Region: TrkA_C; pfam02080
755178007355	TrkA-C domain; Region: TrkA_C; pfam02080
755178007356	Permease SLC13 (solute carrier 13).  The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115
755178007357	Uncharacterized protein related to glutamine synthetase [General function prediction only]; Region: COG3968
755178007358	Glutamine synthetase type III N terminal; Region: GSIII_N; pfam12437
755178007359	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
755178007360	Peptidase family M41; Region: Peptidase_M41; pfam01434
755178007361	GT_2_like_a represents a glycosyltransferase family-2 subfamily with unknown function; Region: GT_2_like_a; cd02522
755178007362	transferase 2, rSAM/selenodomain-associated; Region: glyco_like_mftF; TIGR04283
755178007363	Probable Catalytic site; other site
755178007364	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
755178007365	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
755178007366	diaminopimelate decarboxylase; Region: lysA; TIGR01048
755178007367	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
755178007368	active site
755178007369	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
755178007370	substrate binding site [chemical binding]; other site
755178007371	catalytic residues [active]
755178007372	dimer interface [polypeptide binding]; other site
755178007373	alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561
755178007374	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
755178007375	catalytic site [active]
755178007376	3-deoxy-7-phosphoheptulonate synthase; Provisional; Region: PRK13396
755178007377	phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361
755178007378	Protein of unknown function (DUF3464); Region: DUF3464; pfam11947
755178007379	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
755178007380	16S/18S rRNA binding site [nucleotide binding]; other site
755178007381	S13e-L30e interaction site [polypeptide binding]; other site
755178007382	25S rRNA binding site [nucleotide binding]; other site
755178007383	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
755178007384	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
755178007385	active site
755178007386	phosphorylation site [posttranslational modification]
755178007387	intermolecular recognition site; other site
755178007388	dimerization interface [polypeptide binding]; other site
755178007389	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
755178007390	DNA binding site [nucleotide binding]
755178007391	Protein of unknown function (DUF3353); Region: DUF3353; pfam11833
755178007392	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
755178007393	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
755178007394	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
755178007395	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
755178007396	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
755178007397	recombination protein F; Reviewed; Region: recF; PRK00064
755178007398	ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242
755178007399	Walker A/P-loop; other site
755178007400	ATP binding site [chemical binding]; other site
755178007401	Q-loop/lid; other site
755178007402	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
755178007403	ABC transporter signature motif; other site
755178007404	Walker B; other site
755178007405	D-loop; other site
755178007406	H-loop/switch region; other site
755178007407	Response regulator receiver domain; Region: Response_reg; pfam00072
755178007408	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
755178007409	active site
755178007410	phosphorylation site [posttranslational modification]
755178007411	intermolecular recognition site; other site
755178007412	dimerization interface [polypeptide binding]; other site
755178007413	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
755178007414	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
755178007415	metal binding site [ion binding]; metal-binding site
755178007416	active site
755178007417	I-site; other site
755178007418	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
755178007419	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
755178007420	Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u1; cd11477
755178007421	Na binding site [ion binding]; other site
755178007422	Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798
755178007423	arsenical-resistance protein; Region: acr3; TIGR00832
755178007424	Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1),  6-pyrovoyl...; Region: TFold; cl00263
755178007425	active site
755178007426	6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242
755178007427	active site
755178007428	Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082
755178007429	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
755178007430	Tetramer interface [polypeptide binding]; other site
755178007431	active site
755178007432	FMN-binding site [chemical binding]; other site
755178007433	Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830
755178007434	UreF; Region: UreF; pfam01730
755178007435	Protein of unknown function (DUF2396); Region: DUF2396; pfam09654
755178007436	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
755178007437	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
755178007438	active site
755178007439	metal binding site [ion binding]; metal-binding site
755178007440	Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331
755178007441	TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955
755178007442	catalytic residues [active]
755178007443	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
755178007444	PilZ domain; Region: PilZ; pfam07238
755178007445	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
755178007446	Catalytic domain of Protein Kinases; Region: PKc; cd00180
755178007447	active site
755178007448	ATP binding site [chemical binding]; other site
755178007449	substrate binding site [chemical binding]; other site
755178007450	activation loop (A-loop); other site
755178007451	SOS regulatory protein LexA; Region: lexA; TIGR00498
755178007452	LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726
755178007453	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
755178007454	Catalytic site [active]
755178007455	Domain of unknown function (DUF1730); Region: DUF1730; pfam08331
755178007456	4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484
755178007457	dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726
755178007458	DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442
755178007459	Ligand binding site; other site
755178007460	Putative Catalytic site; other site
755178007461	DXD motif; other site
755178007462	Predicted membrane protein [Function unknown]; Region: COG2246
755178007463	GtrA-like protein; Region: GtrA; pfam04138
755178007464	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
755178007465	Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240
755178007466	Predicted membrane protein [Function unknown]; Region: COG2324
755178007467	OstA-like protein; Region: OstA; cl00844
755178007468	Protein of unknown function (DUF3769); Region: DUF3769; pfam12600
755178007469	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
755178007470	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
755178007471	active site
755178007472	phosphorylation site [posttranslational modification]
755178007473	intermolecular recognition site; other site
755178007474	dimerization interface [polypeptide binding]; other site
755178007475	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
755178007476	DNA binding site [nucleotide binding]
755178007477	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
755178007478	HAMP domain; Region: HAMP; pfam00672
755178007479	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
755178007480	dimer interface [polypeptide binding]; other site
755178007481	phosphorylation site [posttranslational modification]
755178007482	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
755178007483	ATP binding site [chemical binding]; other site
755178007484	Mg2+ binding site [ion binding]; other site
755178007485	G-X-G motif; other site
755178007486	Predicted metal-dependent enzyme of the double-stranded beta helix superfamily [General function prediction only]; Region: COG5553
755178007487	CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421
755178007488	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
755178007489	DXD motif; other site
755178007490	Cellulose synthase-like protein; Region: PLN02893
755178007491	Protein of unknown function (DUF4079); Region: DUF4079; pfam13301
755178007492	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
755178007493	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
755178007494	catalytic residues [active]
755178007495	Thiol-disulfide isomerase and thioredoxins [Posttranslational modification, protein turnover, chaperones / Energy production and conversion]; Region: TrxA; COG0526
755178007496	Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785
755178007497	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; pfam02683
755178007498	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
755178007499	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
755178007500	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
755178007501	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
755178007502	catalytic residues [active]
755178007503	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
755178007504	Protein of unknown function (DUF3179); Region: DUF3179; pfam11376
755178007505	Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these...; Region: PRX_like2; cd02970
755178007506	putative catalytic residues [active]
755178007507	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
755178007508	CBD_II domain; Region: CBD_II; smart00637
755178007509	Calx-beta domain; Region: Calx-beta; pfam03160
755178007510	Cellulose binding domain; Region: CBM_2; cl17741
755178007511	Calx-beta domain; Region: Calx-beta; pfam03160
755178007512	Endoglucanase [Carbohydrate transport and metabolism]; Region: BglC; COG2730
755178007513	Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150
755178007514	Cellulose binding domain; Region: CBM_2; pfam00553
755178007515	oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890
755178007516	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
755178007517	putative substrate translocation pore; other site
755178007518	gamma-glutamyl kinase; Provisional; Region: PRK05429
755178007519	AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242
755178007520	nucleotide binding site [chemical binding]; other site
755178007521	homotetrameric interface [polypeptide binding]; other site
755178007522	putative phosphate binding site [ion binding]; other site
755178007523	putative allosteric binding site; other site
755178007524	PUA domain; Region: PUA; pfam01472
755178007525	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
755178007526	ACT_MalLac-Enz CD includes the N-terminal ACT domain of putative NAD-dependent malic enzyme 1, Bacillus subtilis YqkI and related domains; Region: ACT_MalLac-Enz; cd04887
755178007527	Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281
755178007528	Malic enzyme, N-terminal domain; Region: malic; pfam00390
755178007529	NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311
755178007530	putative NAD(P) binding site [chemical binding]; other site
755178007531	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
755178007532	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933
755178007533	FMN binding site [chemical binding]; other site
755178007534	active site
755178007535	substrate binding site [chemical binding]; other site
755178007536	catalytic residue [active]
755178007537	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
755178007538	Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412
755178007539	dimer interface [polypeptide binding]; other site
755178007540	substrate binding site [chemical binding]; other site
755178007541	metal binding sites [ion binding]; metal-binding site
755178007542	Rec8/ScpA/Scc1-like protein (kleisin family) [Replication,    recombination, and repair]; Region: scpA; COG1354
755178007543	S23 ribosomal protein; Region: Ribosomal_S23p; pfam05635
755178007544	four helix bundle protein; Region: TIGR02436
755178007545	Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426
755178007546	Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753
755178007547	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
755178007548	Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853
755178007549	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
755178007550	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
755178007551	ligand binding site [chemical binding]; other site
755178007552	flexible hinge region; other site
755178007553	ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274
755178007554	Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cd02259
755178007555	putative active site [active]
755178007556	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
755178007557	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
755178007558	Walker A/P-loop; other site
755178007559	ATP binding site [chemical binding]; other site
755178007560	Q-loop/lid; other site
755178007561	ABC transporter signature motif; other site
755178007562	Walker B; other site
755178007563	D-loop; other site
755178007564	H-loop/switch region; other site
755178007565	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
755178007566	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
755178007567	TrkA-N domain; Region: TrkA_N; pfam02254
755178007568	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
755178007569	elongation factor P; Validated; Region: PRK00529
755178007570	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
755178007571	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
755178007572	RNA binding site [nucleotide binding]; other site
755178007573	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
755178007574	RNA binding site [nucleotide binding]; other site
755178007575	acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302
755178007576	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
755178007577	carboxyltransferase (CT) interaction site; other site
755178007578	biotinylation site [posttranslational modification]; other site
755178007579	Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226
755178007580	TrkA-N domain; Region: TrkA_N; pfam02254
755178007581	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
755178007582	TrkA-N domain; Region: TrkA_N; pfam02254
755178007583	cobalt-precorrin-6A synthase; Reviewed; Region: cbiD; PRK00075
755178007584	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
755178007585	active site
755178007586	NTP binding site [chemical binding]; other site
755178007587	metal binding triad [ion binding]; metal-binding site
755178007588	antibiotic binding site [chemical binding]; other site
755178007589	D1, D2 subunits of photosystem II  (PSII); M, L subunits of bacterial photosynthetic reaction center; Region: Photo_RC; cl08220
755178007590	pheophytin binding site; other site
755178007591	chlorophyll binding site; other site
755178007592	quinone binding site; other site
755178007593	Fe binding site [ion binding]; other site
755178007594	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates...; Region: IMPCH; cd01421
755178007595	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881
755178007596	purine monophosphate binding site [chemical binding]; other site
755178007597	dimer interface [polypeptide binding]; other site
755178007598	putative catalytic residues [active]
755178007599	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798
755178007600	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362
755178007601	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
755178007602	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
755178007603	Probable transposase; Region: OrfB_IS605; pfam01385
755178007604	CpcD/allophycocyanin linker domain; Region: CpcD; pfam01383
755178007605	These ferredoxin reductases are related to the NADPH cytochrome p450 reductases (CYPOR), but lack the FAD-binding region connecting sub-domain. Ferredoxin-NADP+ reductase (FNR) is an FAD-containing enzyme that catalyzes the reversible electron transfer...; Region: CYPOR_like_FNR; cd06208
755178007606	ferredoxin--NADP+ reductase; Provisional; Region: PLN03116
755178007607	dimerization interface [polypeptide binding]; other site
755178007608	FAD binding pocket [chemical binding]; other site
755178007609	FAD binding motif [chemical binding]; other site
755178007610	catalytic residues [active]
755178007611	NAD binding pocket [chemical binding]; other site
755178007612	phosphate binding motif [ion binding]; other site
755178007613	beta-alpha-beta structure motif; other site
755178007614	amidophosphoribosyltransferase; Provisional; Region: PRK07349
755178007615	Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of  glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715
755178007616	active site
755178007617	tetramer interface [polypeptide binding]; other site
755178007618	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
755178007619	active site
755178007620	Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352
755178007621	Phosphoenolpyruvate carboxylase; Region: PEPcase; pfam00311
755178007622	S23 ribosomal protein; Region: Ribosomal_S23p; pfam05635
755178007623	four helix bundle protein; Region: TIGR02436
755178007624	Ycf46; Provisional; Region: ycf46; CHL00195
755178007625	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
755178007626	Walker A motif; other site
755178007627	ATP binding site [chemical binding]; other site
755178007628	Walker B motif; other site
755178007629	arginine finger; other site
755178007630	Response regulator receiver domain; Region: Response_reg; pfam00072
755178007631	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
755178007632	active site
755178007633	phosphorylation site [posttranslational modification]
755178007634	intermolecular recognition site; other site
755178007635	dimerization interface [polypeptide binding]; other site
755178007636	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
755178007637	Response regulator receiver domain; Region: Response_reg; pfam00072
755178007638	active site
755178007639	phosphorylation site [posttranslational modification]
755178007640	intermolecular recognition site; other site
755178007641	dimerization interface [polypeptide binding]; other site
755178007642	Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835
755178007643	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
755178007644	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
755178007645	putative tRNA-binding site [nucleotide binding]; other site
755178007646	B3/4 domain; Region: B3_4; pfam03483
755178007647	tRNA synthetase B5 domain; Region: B5; smart00874
755178007648	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
755178007649	dimer interface [polypeptide binding]; other site
755178007650	motif 1; other site
755178007651	motif 3; other site
755178007652	motif 2; other site
755178007653	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; smart00896
755178007654	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
755178007655	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
755178007656	Walker A/P-loop; other site
755178007657	ATP binding site [chemical binding]; other site
755178007658	Q-loop/lid; other site
755178007659	ABC transporter signature motif; other site
755178007660	Walker B; other site
755178007661	D-loop; other site
755178007662	H-loop/switch region; other site
755178007663	polyphosphate kinase; Provisional; Region: PRK05443
755178007664	Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089
755178007665	Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503
755178007666	Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165
755178007667	putative domain interface [polypeptide binding]; other site
755178007668	putative active site [active]
755178007669	catalytic site [active]
755178007670	Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168
755178007671	putative domain interface [polypeptide binding]; other site
755178007672	putative active site [active]
755178007673	catalytic site [active]
755178007674	cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814
755178007675	putative ABC transporter; Region: ycf24; CHL00085
755178007676	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
755178007677	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
755178007678	catalytic residues [active]
755178007679	Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611
755178007680	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
755178007681	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
755178007682	catalytic triad [active]
755178007683	Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189
755178007684	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
755178007685	RNA binding surface [nucleotide binding]; other site
755178007686	FtsJ-like methyltransferase; Region: FtsJ; pfam01728
755178007687	Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312
755178007688	3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772
755178007689	tartrate dehydrogenase; Region: TTC; TIGR02089
755178007690	rod shape-determining protein RodA; Region: rodA_shape; TIGR02210
755178007691	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
755178007692	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
755178007693	dimer interface [polypeptide binding]; other site
755178007694	conserved gate region; other site
755178007695	putative PBP binding loops; other site
755178007696	ABC-ATPase subunit interface; other site
755178007697	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
755178007698	Walker A/P-loop; other site
755178007699	ATP binding site [chemical binding]; other site
755178007700	ABC transporter; Region: ABC_tran; pfam00005
755178007701	Q-loop/lid; other site
755178007702	ABC transporter signature motif; other site
755178007703	Walker B; other site
755178007704	D-loop; other site
755178007705	H-loop/switch region; other site
755178007706	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
755178007707	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
755178007708	membrane-bound complex binding site; other site
755178007709	hinge residues; other site
755178007710	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
755178007711	Catalytic domain of Protein Kinases; Region: PKc; cd00180
755178007712	active site
755178007713	ATP binding site [chemical binding]; other site
755178007714	substrate binding site [chemical binding]; other site
755178007715	activation loop (A-loop); other site
755178007716	DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142
755178007717	catalytic site [active]
755178007718	putative active site [active]
755178007719	putative substrate binding site [chemical binding]; other site
755178007720	GIY-YIG nuclease domain superfamily; Region: GIY-YIG_SF; cl15257
755178007721	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
755178007722	Peptidase family M28; Region: Peptidase_M28; pfam04389
755178007723	metal binding site [ion binding]; metal-binding site
755178007724	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
755178007725	MoxR-like ATPases [General function prediction only]; Region: COG0714
755178007726	Walker A motif; other site
755178007727	ATP binding site [chemical binding]; other site
755178007728	Walker B motif; other site
755178007729	arginine finger; other site
755178007730	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3864
755178007731	Putative metallopeptidase domain; Region: DUF2201_N; pfam13203
755178007732	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
755178007733	metal ion-dependent adhesion site (MIDAS); other site
755178007734	Helix-turn-helix domain; Region: HTH_17; pfam12728
755178007735	DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847
755178007736	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
755178007737	active site
755178007738	catalytic site [active]
755178007739	substrate binding site [chemical binding]; other site
755178007740	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
755178007741	Walker A motif; other site
755178007742	ATP binding site [chemical binding]; other site
755178007743	Walker B motif; other site
755178007744	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497
755178007745	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
755178007746	Walker A/P-loop; other site
755178007747	ATP binding site [chemical binding]; other site
755178007748	Q-loop/lid; other site
755178007749	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
755178007750	ABC transporter signature motif; other site
755178007751	Walker B; other site
755178007752	D-loop; other site
755178007753	H-loop/switch region; other site
755178007754	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
755178007755	dimerization interface [polypeptide binding]; other site
755178007756	putative DNA binding site [nucleotide binding]; other site
755178007757	putative Zn2+ binding site [ion binding]; other site
755178007758	4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Provisional; Region: PRK13371
755178007759	(E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate reductase (IPP and DMAPP forming); Region: ispH_lytB; TIGR00216
755178007760	Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405
755178007761	Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019
755178007762	putative alpha-isopropylmalate/homocitrate synthase family transferase; Provisional; Region: PRK12344
755178007763	Desulfobacterium autotrophicum LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA3; cd07941
755178007764	active site
755178007765	catalytic residues [active]
755178007766	metal binding site [ion binding]; metal-binding site
755178007767	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917
755178007768	tRNA pseudouridine synthase B; Provisional; Region: truB; PRK02755
755178007769	Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573
755178007770	RNA binding site [nucleotide binding]; other site
755178007771	active site
755178007772	Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157
755178007773	Mo-dependent nitrogenase C-terminus; Region: Mo-nitro_C; pfam06967
755178007774	Photosystem II protein Y (PsbY); Region: PsbY; pfam06298
755178007775	Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644
755178007776	tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091
755178007777	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
755178007778	photosystem I reaction center subunit X; Reviewed; Region: PRK13214
755178007779	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
755178007780	Mechanosensitive ion channel; Region: MS_channel; pfam00924
755178007781	AAA domain; Region: AAA_22; pfam13401
755178007782	FO synthase subunit 1; Reviewed; Region: cofG; PRK06245
755178007783	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
755178007784	FeS/SAM binding site; other site
755178007785	Toxin with endonuclease activity YhaV; Region: Toxin_YhaV; pfam11663
755178007786	Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877
755178007787	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
755178007788	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
755178007789	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
755178007790	NAD(P)H-quinone oxidoreductase subunit 4; Provisional; Region: PRK02546
755178007791	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
755178007792	phosphoglucomutase; Region: PLN02307
755178007793	Phosphoglucomutase 1 (PGM1) catalyzes the bidirectional interconversion of glucose-1-phosphate (G-1-P) and glucose-6-phosphate (G-6-P) via a glucose 1,6-diphosphate intermediate, an important metabolic step in prokaryotes and eukaryotes. In one direction; Region: PGM1; cd03085
755178007794	substrate binding site [chemical binding]; other site
755178007795	dimer interface [polypeptide binding]; other site
755178007796	active site
755178007797	metal binding site [ion binding]; metal-binding site
755178007798	LabA_like proteins; Region: LabA_like/DUF88; cl10034
755178007799	putative metal binding site [ion binding]; other site
755178007800	Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170
755178007801	nucleotide binding site [chemical binding]; other site
755178007802	putative NEF/HSP70 interaction site [polypeptide binding]; other site
755178007803	SBD interface [polypeptide binding]; other site
755178007804	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
755178007805	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cl00047
755178007806	ligand binding site [chemical binding]; other site
755178007807	flexible hinge region; other site
755178007808	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
755178007809	non-specific DNA interactions [nucleotide binding]; other site
755178007810	DNA binding site [nucleotide binding]
755178007811	sequence specific DNA binding site [nucleotide binding]; other site
755178007812	putative cAMP binding site [chemical binding]; other site
755178007813	WYL domain; Region: WYL; pfam13280
755178007814	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
755178007815	active site
755178007816	NTP binding site [chemical binding]; other site
755178007817	metal binding triad [ion binding]; metal-binding site
755178007818	antibiotic binding site [chemical binding]; other site
755178007819	Protein of unknown function DUF86; Region: DUF86; cl01031
755178007820	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
755178007821	active site
755178007822	NTP binding site [chemical binding]; other site
755178007823	metal binding triad [ion binding]; metal-binding site
755178007824	antibiotic binding site [chemical binding]; other site
755178007825	Protein of unknown function DUF86; Region: DUF86; pfam01934
755178007826	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
755178007827	active site
755178007828	NTP binding site [chemical binding]; other site
755178007829	metal binding triad [ion binding]; metal-binding site
755178007830	antibiotic binding site [chemical binding]; other site
755178007831	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
755178007832	CRISPR-associated helicase Cas3; Region: cas3_core; TIGR01587
755178007833	CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cl11443
755178007834	CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cd09652
755178007835	Predicted aspartyl protease [Posttranslational modification, protein turnover, chaperones]; Region: COG5550; cl17622
755178007836	CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cd09637
755178007837	S23 ribosomal protein; Region: Ribosomal_S23p; cl05287
755178007838	four helix bundle protein; Region: TIGR02436
755178007839	CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cd09634
755178007840	CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725
755178007841	Response regulator receiver domain; Region: Response_reg; pfam00072
755178007842	POTRA domain, ShlB-type; Region: POTRA_2; pfam08479
755178007843	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
755178007844	Surface antigen; Region: Bac_surface_Ag; pfam01103
755178007845	phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362
755178007846	bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415
755178007847	ATP binding site [chemical binding]; other site
755178007848	active site
755178007849	substrate binding site [chemical binding]; other site
755178007850	DNA polymerase III subunit delta'; Validated; Region: PRK07399
755178007851	DNA polymerase III subunit delta'; Validated; Region: PRK08485
755178007852	6-phosphofructokinase; Provisional; Region: PRK03202
755178007853	6-phosphofructokinase; Region: PFKA_ATP; TIGR02482
755178007854	active site
755178007855	ADP/pyrophosphate binding site [chemical binding]; other site
755178007856	dimerization interface [polypeptide binding]; other site
755178007857	allosteric effector site; other site
755178007858	fructose-1,6-bisphosphate binding site; other site
755178007859	photosystem I assembly protein Ycf4; Provisional; Region: PRK02542
755178007860	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
755178007861	Rieske non-heme iron oxygenase (RO) family, Pheophorbide a oxygenase (PaO) subfamily, N-terminal Rieske domain of the oxygenase alpha subunit; composed of the oxygenase alpha subunits of a small subfamily of enzymes found in plants as well as oxygenic...; Region: Rieske_RO_Alpha_PaO; cd03480
755178007862	Pheophorbide a oxygenase; Region: PaO; pfam08417
755178007863	Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506
755178007864	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
755178007865	XisH protein; Region: XisH; pfam08814
755178007866	XisI protein; Region: XisI; pfam08869
755178007867	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
755178007868	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
755178007869	active site
755178007870	phosphorylation site [posttranslational modification]
755178007871	intermolecular recognition site; other site
755178007872	dimerization interface [polypeptide binding]; other site
755178007873	PAS domain S-box; Region: sensory_box; TIGR00229
755178007874	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
755178007875	putative active site [active]
755178007876	heme pocket [chemical binding]; other site
755178007877	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
755178007878	GAF domain; Region: GAF; cl17456
755178007879	Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208
755178007880	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
755178007881	Myxococcus xanthus DevT and related proteins, metallophosphatase domain; Region: MPP_DevT; cd07397
755178007882	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
755178007883	putative active site [active]
755178007884	putative metal binding site [ion binding]; other site
755178007885	Protein of unknown function (DUF1092); Region: DUF1092; pfam06485
755178007886	phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135
755178007887	PhoU domain; Region: PhoU; pfam01895
755178007888	PhoU domain; Region: PhoU; pfam01895
755178007889	Creatinine amidohydrolase; Region: Creatininase; pfam02633
755178007890	Domain of unknown function (DUF4168); Region: DUF4168; pfam13767
755178007891	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
755178007892	H+ Antiporter protein; Region: 2A0121; TIGR00900
755178007893	putative substrate translocation pore; other site
755178007894	Protein of unknown function (DUF3067); Region: DUF3067; pfam11267
755178007895	Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877
755178007896	PIN domain; Region: PIN_3; cl17397
755178007897	cytochrome b6-f complex iron-sulfur subunit; Provisional; Region: PRK13474
755178007898	Cytochrome B6-F complex Fe-S subunit; Region: CytB6-F_Fe-S; pfam08802
755178007899	Iron-sulfur protein (ISP) component of the b6f complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The cytochrome b6f complex from Mastigocladus laminosus, a thermophilic cyanobacterium; Region: Rieske_cytochrome_b6f; cd03471
755178007900	cytochrome b subunit interaction site [polypeptide binding]; other site
755178007901	[2Fe-2S] cluster binding site [ion binding]; other site
755178007902	cytochrome f; Region: petA; CHL00037
755178007903	apocytochrome f; Reviewed; Region: PRK02693
755178007904	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
755178007905	phosphopeptide binding site; other site
755178007906	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
755178007907	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
755178007908	phosphopeptide binding site; other site
755178007909	The Eye Pigment Precursor Transporter (EPP) Family protein; Region: 3a01204; TIGR00955
755178007910	Eye pigment and drug resistance transporter subfamily G of the ATP-binding cassette superfamily; Region: ABCG_EPDR; cd03213
755178007911	Walker A/P-loop; other site
755178007912	ATP binding site [chemical binding]; other site
755178007913	Q-loop/lid; other site
755178007914	ABC transporter signature motif; other site
755178007915	Walker B; other site
755178007916	D-loop; other site
755178007917	H-loop/switch region; other site
755178007918	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
755178007919	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268
755178007920	Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  These two proteins are lipid raft-associated.  Individual proteins of...; Region: Band_7_flotillin; cd03399
755178007921	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
755178007922	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
755178007923	Predicted membrane protein (DUF2232); Region: DUF2232; cl01728
755178007924	Aerobic Cyclase System Fe-containing subunit (ACSF), ferritin-like diiron-binding domain; Region: ACSF; cd01047
755178007925	diiron binding motif [ion binding]; other site
755178007926	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
755178007927	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
755178007928	anti sigma factor interaction site; other site
755178007929	regulatory phosphorylation site [posttranslational modification]; other site
755178007930	BioY family; Region: BioY; pfam02632
755178007931	biotin synthase; Region: bioB; TIGR00433
755178007932	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
755178007933	FeS/SAM binding site; other site
755178007934	Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968
755178007935	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544
755178007936	Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165
755178007937	Uncharacterized conserved protein [Function unknown]; Region: COG5464
755178007938	Protein of unknown function (DUF2887); Region: DUF2887; pfam11103
755178007939	hypothetical protein; Provisional; Region: PRK10506
755178007940	Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165
755178007941	tyrosyl-tRNA synthetase; Validated; Region: PRK05912
755178007942	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
755178007943	active site
755178007944	HIGH motif; other site
755178007945	dimer interface [polypeptide binding]; other site
755178007946	KMSKS motif; other site
755178007947	WD domain, G-beta repeat; Region: WD40; pfam00400
755178007948	FOG: WD40 repeat [General function prediction only]; Region: COG2319
755178007949	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
755178007950	structural tetrad; other site
755178007951	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
755178007952	KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454
755178007953	substrate-cofactor binding pocket; other site
755178007954	pyridoxal 5'-phosphate binding site [chemical binding]; other site
755178007955	catalytic residue [active]
755178007956	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
755178007957	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
755178007958	phosphopeptide binding site; other site
755178007959	UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472
755178007960	The members of this subfamily catalyze the formation of a phosphodiester bond between a membrane-associated undecaprenyl-phosphate (Und-P) molecule and N-acetylhexosamine 1-phosphate, which is usually donated by a soluble UDP-N-acetylhexosamine precursor; Region: GT_WbpL_WbcO_like; cd06854
755178007961	Mg++ binding site [ion binding]; other site
755178007962	putative catalytic motif [active]
755178007963	putative substrate binding site [chemical binding]; other site
755178007964	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
755178007965	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
755178007966	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
755178007967	protein binding site [polypeptide binding]; other site
755178007968	Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3972
755178007969	Family description; Region: UvrD_C_2; pfam13538
755178007970	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
755178007971	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
755178007972	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
755178007973	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
755178007974	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
755178007975	FtsX-like permease family; Region: FtsX; pfam02687
755178007976	Protein of unknown function (DUF1997); Region: DUF1997; pfam09366
755178007977	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
755178007978	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
755178007979	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
755178007980	Probable transposase; Region: OrfB_IS605; pfam01385
755178007981	ferredoxin-sulfite reductase; Region: sir; TIGR02042
755178007982	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
755178007983	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
755178007984	FeoA domain; Region: FeoA; pfam04023
755178007985	Bacterial sugar transferase; Region: Bac_transf; pfam02397
755178007986	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
755178007987	This family is most closely related to the GT1 family of glycosyltransferases.  wbaZ in Salmonella enterica has been shown to possess the mannosyl transferase activity. The members of this family are found in certain bacteria and Archaea; Region: GT1_wbaZ_like; cd03804
755178007988	putative ADP-binding pocket [chemical binding]; other site
755178007989	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
755178007990	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
755178007991	dimer interface [polypeptide binding]; other site
755178007992	ssDNA binding site [nucleotide binding]; other site
755178007993	tetramer (dimer of dimers) interface [polypeptide binding]; other site
755178007994	pyruvate dehydrogenase E1 component beta subunit; Validated; Region: odpB; CHL00144
755178007995	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
755178007996	alpha subunit interface [polypeptide binding]; other site
755178007997	TPP binding site [chemical binding]; other site
755178007998	heterodimer interface [polypeptide binding]; other site
755178007999	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
755178008000	protein-export membrane protein SecD; Region: secD; TIGR01129
755178008001	protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916
755178008002	preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022
755178008003	Protein export membrane protein; Region: SecD_SecF; pfam02355
755178008004	Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062
755178008005	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
755178008006	substrate binding pocket [chemical binding]; other site
755178008007	membrane-bound complex binding site; other site
755178008008	hinge residues; other site
755178008009	F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711
755178008010	ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192
755178008011	16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122
755178008012	RimM N-terminal domain; Region: RimM; pfam01782
755178008013	PRC-barrel domain; Region: PRC; pfam05239
755178008014	chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169
755178008015	Part of AAA domain; Region: AAA_19; pfam13245
755178008016	photosystem II protein PsbQ; Region: PS_II_psbQ_bact; TIGR03042
755178008017	bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14360
755178008018	N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540
755178008019	Substrate binding site; other site
755178008020	Mg++ binding site; other site
755178008021	N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353
755178008022	active site
755178008023	substrate binding site [chemical binding]; other site
755178008024	CoA binding site [chemical binding]; other site
755178008025	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
755178008026	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
755178008027	active site residue [active]
755178008028	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
755178008029	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
755178008030	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
755178008031	dimer interface [polypeptide binding]; other site
755178008032	phosphorylation site [posttranslational modification]
755178008033	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
755178008034	ATP binding site [chemical binding]; other site
755178008035	Mg2+ binding site [ion binding]; other site
755178008036	G-X-G motif; other site
755178008037	Domain of unknown function (DUF1823); Region: DUF1823; pfam08853
755178008038	Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276
755178008039	nucleotide binding site/active site [active]
755178008040	HIT family signature motif; other site
755178008041	catalytic residue [active]
755178008042	Helix-hairpin-helix motif; Region: HHH_3; pfam12836
755178008043	Predicted membrane protein [Function unknown]; Region: XynA; COG2314
755178008044	Short C-terminal domain; Region: SHOCT; pfam09851
755178008045	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
755178008046	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
755178008047	Probable transposase; Region: OrfB_IS605; pfam01385
755178008048	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
755178008049	Alpha-amylase/alpha-mannosidase [Carbohydrate transport and metabolism]; Region: COG1449
755178008050	Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191
755178008051	N-terminal catalytic domain of thermoactive amylopullulanases; glycoside hydrolase family 57 (GH57); Region: GH57N_APU; cd10796
755178008052	putative active site [active]
755178008053	catalytic site [active]
755178008054	Two component signalling adaptor domain; Region: CheW; smart00260
755178008055	succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK05945
755178008056	L-aspartate oxidase; Provisional; Region: PRK06175
755178008057	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
755178008058	S23 ribosomal protein; Region: Ribosomal_S23p; pfam05635
755178008059	four helix bundle protein; Region: TIGR02436
755178008060	molecular chaperone DnaK; Provisional; Region: PRK13410
755178008061	Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234
755178008062	nucleotide binding site [chemical binding]; other site
755178008063	NEF interaction site [polypeptide binding]; other site
755178008064	SBD interface [polypeptide binding]; other site
755178008065	Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079
755178008066	gamma-glutamyl phosphate reductase; Region: proA; TIGR00407
755178008067	putative catalytic cysteine [active]
755178008068	acetolactate synthase 3 catalytic subunit; Reviewed; Region: PRK07418
755178008069	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
755178008070	PYR/PP interface [polypeptide binding]; other site
755178008071	dimer interface [polypeptide binding]; other site
755178008072	TPP binding site [chemical binding]; other site
755178008073	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
755178008074	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
755178008075	TPP-binding site [chemical binding]; other site
755178008076	dimer interface [polypeptide binding]; other site
755178008077	zinc-ribbon domain; Region: zf-ribbon_3; pfam13248
755178008078	Uncharacterized conserved protein [Function unknown]; Region: COG2968
755178008079	Protein of unknown function (DUF541); Region: SIMPL; pfam04402
755178008080	Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140
755178008081	Catalytic site; other site
755178008082	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
755178008083	Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_11; cd06346
755178008084	putative ligand binding site [chemical binding]; other site
755178008085	Predicted transmembrane sensor domain [Signal transduction mechanisms]; Region: COG4252
755178008086	CHASE2 domain; Region: CHASE2; pfam05226
755178008087	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
755178008088	cyclase homology domain; Region: CHD; cd07302
755178008089	nucleotidyl binding site; other site
755178008090	metal binding site [ion binding]; metal-binding site
755178008091	dimer interface [polypeptide binding]; other site
755178008092	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
755178008093	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
755178008094	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
755178008095	protein binding site [polypeptide binding]; other site
755178008096	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
755178008097	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
755178008098	HlyD family secretion protein; Region: HlyD_3; pfam13437
755178008099	GUN4-like; Region: GUN4; pfam05419
755178008100	N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655
755178008101	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
755178008102	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
755178008103	putative active site [active]
755178008104	putative NTP binding site [chemical binding]; other site
755178008105	putative nucleic acid binding site [nucleotide binding]; other site
755178008106	glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810
755178008107	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
755178008108	Domain of unknown function (DUF4010); Region: DUF4010; pfam13194
755178008109	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
755178008110	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
755178008111	Domain of unknown function (DUF4129); Region: DUF4129; pfam13559
755178008112	lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025
755178008113	ipid-A-disaccharide synthase; Provisional; Region: PRK14089
755178008114	lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376
755178008115	glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233
755178008116	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
755178008117	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
755178008118	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
755178008119	catalytic core [active]
755178008120	Fe(II)-dependent oxygenase superfamily protein; Provisional; Region: PRK05467
755178008121	Heterodisulfide reductase, subunit B [Energy production and conversion]; Region: HdrB; COG2048
755178008122	Cysteine-rich domain; Region: CCG; pfam02754
755178008123	Cysteine-rich domain; Region: CCG; pfam02754
755178008124	4Fe-4S dicluster domain; Region: Fer4_17; pfam13534
755178008125	Heterodisulfide reductase, subunit A and related polyferredoxins [Energy production and conversion]; Region: HdrA; COG1148
755178008126	Heterodisulfide reductase, subunit B [Energy production and conversion]; Region: HdrB; COG2048
755178008127	Cysteine-rich domain; Region: CCG; pfam02754
755178008128	4Fe-4S dicluster domain; Region: Fer4_17; pfam13534
755178008129	ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178
755178008130	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
755178008131	dimer interface [polypeptide binding]; other site
755178008132	conserved gate region; other site
755178008133	putative PBP binding loops; other site
755178008134	ABC-ATPase subunit interface; other site
755178008135	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
755178008136	dimer interface [polypeptide binding]; other site
755178008137	conserved gate region; other site
755178008138	putative PBP binding loops; other site
755178008139	ABC-ATPase subunit interface; other site
755178008140	beta propeller repeat, Methanosarcina surface protein type; Region: beta_prop_Msarc; TIGR04275
755178008141	PBP superfamily domain; Region: PBP_like_2; cl17296
755178008142	GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239
755178008143	GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725
755178008144	NADP binding site [chemical binding]; other site
755178008145	active site
755178008146	putative substrate binding site [chemical binding]; other site
755178008147	Bacitracin resistance protein BacA; Region: BacA; pfam02673
755178008148	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
755178008149	TPR motif; other site
755178008150	binding surface
755178008151	TPR repeat; Region: TPR_11; pfam13414
755178008152	TPR repeat; Region: TPR_11; pfam13414
755178008153	TPR repeat; Region: TPR_11; pfam13414
755178008154	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
755178008155	TPR motif; other site
755178008156	binding surface
755178008157	Tetratricopeptide repeat; Region: TPR_16; pfam13432
755178008158	TPR repeat; Region: TPR_11; pfam13414
755178008159	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
755178008160	binding surface
755178008161	TPR motif; other site
755178008162	TPR repeat; Region: TPR_11; pfam13414
755178008163	Protein of unknown function (DUF2930); Region: DUF2930; pfam11152
755178008164	GAF domain; Region: GAF_2; pfam13185
755178008165	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
755178008166	FOG: WD40 repeat [General function prediction only]; Region: COG2319
755178008167	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
755178008168	Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498
755178008169	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3330
755178008170	Methyltransferase domain; Region: Methyltransf_23; pfam13489
755178008171	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
755178008172	S-adenosylmethionine binding site [chemical binding]; other site
755178008173	Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537
755178008174	nucleotide binding site/active site [active]
755178008175	HIT family signature motif; other site
755178008176	catalytic residue [active]
755178008177	gliding motility-associated ABC transporter permease protein GldF; Region: ABC_perm_GldF; TIGR03518
755178008178	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
755178008179	active site
755178008180	NTP binding site [chemical binding]; other site
755178008181	metal binding triad [ion binding]; metal-binding site
755178008182	antibiotic binding site [chemical binding]; other site
755178008183	Uncharacterized conserved protein [Function unknown]; Region: COG2361
755178008184	ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073
755178008185	Part of AAA domain; Region: AAA_19; pfam13245
755178008186	Family description; Region: UvrD_C_2; pfam13538
755178008187	Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate  into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354
755178008188	AMP binding site [chemical binding]; other site
755178008189	metal binding site [ion binding]; metal-binding site
755178008190	active site
755178008191	Clp protease; Region: CLP_protease; pfam00574
755178008192	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
755178008193	oligomer interface [polypeptide binding]; other site
755178008194	active site residues [active]
755178008195	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
755178008196	ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689
755178008197	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078
755178008198	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
755178008199	Walker A motif; other site
755178008200	ATP binding site [chemical binding]; other site
755178008201	Walker B motif; other site
755178008202	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
755178008203	FtsH Extracellular; Region: FtsH_ext; pfam06480
755178008204	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
755178008205	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
755178008206	Walker A motif; other site
755178008207	ATP binding site [chemical binding]; other site
755178008208	Walker B motif; other site
755178008209	arginine finger; other site
755178008210	Peptidase family M41; Region: Peptidase_M41; pfam01434
755178008211	tryptophan synthase, beta subunit; Region: trpB; TIGR00263
755178008212	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
755178008213	pyridoxal 5'-phosphate binding site [chemical binding]; other site
755178008214	catalytic residue [active]
755178008215	5-oxoprolinase; Region: PLN02666
755178008216	Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378
755178008217	Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968
755178008218	N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146
755178008219	S23 ribosomal protein; Region: Ribosomal_S23p; pfam05635
755178008220	four helix bundle protein; Region: TIGR02436
755178008221	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
755178008222	active site
755178008223	FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545
755178008224	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
755178008225	Domain of unknown function (DUF4336); Region: DUF4336; pfam14234
755178008226	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
755178008227	S-adenosylmethionine binding site [chemical binding]; other site
755178008228	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
755178008229	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
755178008230	Tfp pilus assembly protein, ATPase PilM [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilM; COG4972
755178008231	Cell division protein FtsA; Region: FtsA; cl17206
755178008232	Fimbrial assembly protein (PilN); Region: PilN; pfam05137
755178008233	Type II secretory pathway, component HofQ [Intracellular trafficking and secretion]; Region: HofQ; COG4796
755178008234	Secretin and TonB N terminus short domain; Region: STN; pfam07660
755178008235	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
755178008236	DDE superfamily endonuclease; Region: DDE_5; cl17874
755178008237	DNA mismatch repair protein MutS; Provisional; Region: PRK05399
755178008238	MutS domain I; Region: MutS_I; pfam01624
755178008239	MutS domain II; Region: MutS_II; pfam05188
755178008240	MutS domain III; Region: MutS_III; pfam05192
755178008241	ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284
755178008242	Walker A/P-loop; other site
755178008243	ATP binding site [chemical binding]; other site
755178008244	Q-loop/lid; other site
755178008245	ABC transporter signature motif; other site
755178008246	Walker B; other site
755178008247	D-loop; other site
755178008248	H-loop/switch region; other site
755178008249	Protein of unknown function (DUF2283); Region: DUF2283; pfam10049
755178008250	melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392
755178008251	sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792
755178008252	melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392
755178008253	Uncharacterized conserved protein [Function unknown]; Region: COG1565
755178008254	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
755178008255	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
755178008256	phosphopeptide binding site; other site
755178008257	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
755178008258	PAS domain S-box; Region: sensory_box; TIGR00229
755178008259	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
755178008260	putative active site [active]
755178008261	heme pocket [chemical binding]; other site
755178008262	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
755178008263	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
755178008264	metal binding site [ion binding]; metal-binding site
755178008265	active site
755178008266	I-site; other site
755178008267	ATP-utilizing enzymes of the PP-loop superfamily [General function prediction only]; Region: COG1606
755178008268	This is a subfamily of Adenine nucleotide alpha hydrolases superfamily. Adenine nucleotide alpha hydrolases superfamily  includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which  binds to Adenosine group.  This subfamily; Region: Alpha_ANH_like_I; cd01990
755178008269	Ligand Binding Site [chemical binding]; other site
755178008270	OstA-like protein; Region: OstA; pfam03968
755178008271	ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137
755178008272	ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218
755178008273	Walker A/P-loop; other site
755178008274	ATP binding site [chemical binding]; other site
755178008275	Q-loop/lid; other site
755178008276	ABC transporter signature motif; other site
755178008277	Walker B; other site
755178008278	D-loop; other site
755178008279	H-loop/switch region; other site
755178008280	Predicted permeases [General function prediction only]; Region: COG0795
755178008281	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
755178008282	transcription antitermination protein NusB; Provisional; Region: nusB; PRK09634
755178008283	putative RNA binding site [nucleotide binding]; other site
755178008284	cytochrome c6; Provisional; Region: PRK13697
755178008285	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
755178008286	peptide chain release factor 1; Validated; Region: prfA; PRK00591
755178008287	This domain is found in peptide chain release factors; Region: PCRF; smart00937
755178008288	RF-1 domain; Region: RF-1; pfam00472
755178008289	Glucokinase; Region: Glucokinase; pfam02685
755178008290	glucokinase, proteobacterial type; Region: glk; TIGR00749
755178008291	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
755178008292	Resolvase, N terminal domain; Region: Resolvase; smart00857
755178008293	Recombinase; Region: Recombinase; pfam07508
755178008294	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
755178008295	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
755178008296	Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233
755178008297	dimer interface [polypeptide binding]; other site
755178008298	active site
755178008299	metal binding site [ion binding]; metal-binding site
755178008300	glutathione binding site [chemical binding]; other site
755178008301	pyridine nucleotide-disulfide oxidoreductase family protein; Region: Nterm_to_SelD; TIGR03169
755178008302	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
755178008303	RNA polymerase Rpb6; Region: RNA_pol_Rpb6; cl14651
755178008304	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
755178008305	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
755178008306	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
755178008307	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
755178008308	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
755178008309	metal ion-dependent adhesion site (MIDAS); other site
755178008310	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
755178008311	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
755178008312	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
755178008313	dimer interface [polypeptide binding]; other site
755178008314	phosphorylation site [posttranslational modification]
755178008315	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
755178008316	ATP binding site [chemical binding]; other site
755178008317	Mg2+ binding site [ion binding]; other site
755178008318	G-X-G motif; other site
755178008319	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
755178008320	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
755178008321	active site
755178008322	phosphorylation site [posttranslational modification]
755178008323	intermolecular recognition site; other site
755178008324	dimerization interface [polypeptide binding]; other site
755178008325	Response regulator receiver domain; Region: Response_reg; pfam00072
755178008326	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
755178008327	active site
755178008328	phosphorylation site [posttranslational modification]
755178008329	intermolecular recognition site; other site
755178008330	dimerization interface [polypeptide binding]; other site
755178008331	DDE superfamily endonuclease; Region: DDE_3; pfam13358
755178008332	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
755178008333	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
755178008334	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
755178008335	NAD(P) binding site [chemical binding]; other site
755178008336	active site
755178008337	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
755178008338	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
755178008339	active site
755178008340	phosphorylation site [posttranslational modification]
755178008341	intermolecular recognition site; other site
755178008342	dimerization interface [polypeptide binding]; other site
755178008343	KaiB-like family; composed of the circadian clock proteins, KaiB and the N-terminal KaiB-like sensory domain of SasA. KaiB is an essential protein in maintaining circadian rhythm. It was originally discovered from the cyanobacterium Synechococcus as part...; Region: KaiB_like; cd02978
755178008344	tetramer interface [polypeptide binding]; other site
755178008345	dimer interface [polypeptide binding]; other site
755178008346	RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398
755178008347	tetramer (dimer of dimers) interface [polypeptide binding]; other site
755178008348	active site
755178008349	dimer interface [polypeptide binding]; other site
755178008350	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
755178008351	Mechanosensitive ion channel; Region: MS_channel; pfam00924
755178008352	Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498
755178008353	Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of  threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563
755178008354	homodimer interface [polypeptide binding]; other site
755178008355	pyridoxal 5'-phosphate binding site [chemical binding]; other site
755178008356	catalytic residue [active]
755178008357	AhpC/TSA antioxidant enzyme; Region: AhpC-TSA_2; pfam13911
755178008358	AhpC/TSA antioxidant enzyme; Region: AhpC-TSA_2; pfam13911
755178008359	leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
755178008360	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
755178008361	HIGH motif; other site
755178008362	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
755178008363	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
755178008364	active site
755178008365	KMSKS motif; other site
755178008366	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
755178008367	tRNA binding surface [nucleotide binding]; other site
755178008368	Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285
755178008369	MgtC family; Region: MgtC; pfam02308
755178008370	Protein of unknown function (DUF3352); Region: DUF3352; pfam11832
755178008371	Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719
755178008372	FeS assembly protein SufD; Region: sufD; TIGR01981
755178008373	sulfate ABC transporter protein; Validated; Region: ycf16; CHL00131
755178008374	ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217
755178008375	Walker A/P-loop; other site
755178008376	ATP binding site [chemical binding]; other site
755178008377	Q-loop/lid; other site
755178008378	ABC transporter signature motif; other site
755178008379	Walker B; other site
755178008380	D-loop; other site
755178008381	H-loop/switch region; other site
755178008382	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
755178008383	NlpC/P60 family; Region: NLPC_P60; pfam00877
755178008384	tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026
755178008385	Type 1 glutamine amidotransferase (GATase1)-like domain found in cyanophycinase; Region: GAT1_cyanophycinase; cd03145
755178008386	proposed catalytic triad [active]
755178008387	active site nucleophile [active]
755178008388	cyanophycin synthetase; Region: cya_phycin_syn; TIGR02068
755178008389	ATP-grasp domain; Region: ATP-grasp_4; cl17255
755178008390	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
755178008391	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
755178008392	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
755178008393	Catalytic domain of Protein Kinases; Region: PKc; cd00180
755178008394	active site
755178008395	ATP binding site [chemical binding]; other site
755178008396	substrate binding site [chemical binding]; other site
755178008397	activation loop (A-loop); other site
755178008398	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
755178008399	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
755178008400	Catalytic site [active]
755178008401	photosystem II protein Psb27; Region: PS_II_psb27; TIGR03044
755178008402	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
755178008403	Endopeptidases that belong to the bidirectional NAD-linked hydrogenase group. This group of endopeptidases are highly specific carboxyl-terminal protease (HoxW protease) which releases a 24-amino-acid peptide from HoxH prior to progression of subunit...; Region: H2MP_NAD-link-bidir; cd06066
755178008404	nickel binding site [ion binding]; other site
755178008405	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in a group of uncharacterized proteins from archaea and bacteria; Region: NTP-PPase_COG4997; cd11532
755178008406	metal binding site [ion binding]; metal-binding site
755178008407	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
755178008408	AAA domain; Region: AAA_23; pfam13476
755178008409	Walker A/P-loop; other site
755178008410	ATP binding site [chemical binding]; other site
755178008411	Uncharacterized conserved protein [Function unknown]; Region: COG4938
755178008412	Protein of unknown function (DUF3696); Region: DUF3696; pfam12476
755178008413	Protein of unknown function DUF262; Region: DUF262; pfam03235
755178008414	Uncharacterized conserved protein [Function unknown]; Region: COG2442
755178008415	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4634
755178008416	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
755178008417	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
755178008418	Probable transposase; Region: OrfB_IS605; pfam01385
755178008419	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
755178008420	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
755178008421	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
755178008422	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
755178008423	PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861
755178008424	putative active site [active]
755178008425	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
755178008426	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
755178008427	glutaminase active site [active]
755178008428	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
755178008429	dimer interface [polypeptide binding]; other site
755178008430	active site
755178008431	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
755178008432	dimer interface [polypeptide binding]; other site
755178008433	active site
755178008434	Protein of unknown function (DUF3172); Region: DUF3172; pfam11371
755178008435	ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127
755178008436	ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261
755178008437	Walker A/P-loop; other site
755178008438	ATP binding site [chemical binding]; other site
755178008439	Q-loop/lid; other site
755178008440	ABC transporter signature motif; other site
755178008441	Walker B; other site
755178008442	D-loop; other site
755178008443	H-loop/switch region; other site
755178008444	ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463
755178008445	mce related protein; Region: MCE; pfam02470
755178008446	Transposase IS200 like; Region: Y1_Tnp; cl00848
755178008447	isoleucyl-tRNA synthetase; Region: PLN02843
755178008448	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
755178008449	HIGH motif; other site
755178008450	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
755178008451	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
755178008452	active site
755178008453	KMSKS motif; other site
755178008454	Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960
755178008455	tRNA binding surface [nucleotide binding]; other site
755178008456	anticodon binding site; other site
755178008457	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
755178008458	Protein of unknown function (DUF2283); Region: DUF2283; pfam10049
755178008459	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604
755178008460	Plasmid encoded toxin Txe; Region: Plasmid_Txe; cl17389
755178008461	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
755178008462	ClC chloride channel EriC.  This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031
755178008463	Cl- selectivity filter; other site
755178008464	Cl- binding residues [ion binding]; other site
755178008465	pore gating glutamate residue; other site
755178008466	dimer interface [polypeptide binding]; other site
755178008467	H+/Cl- coupling transport residue; other site
755178008468	FOG: CBS domain [General function prediction only]; Region: COG0517
755178008469	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with either the SpoIVFB domain (sporulation protein, stage IV cell wall formation, F locus, promoter-distal B) or the chloride channel protein EriC; Region: CBS_pair_SpoIVFB_EriC_assoc; cd04612
755178008470	The C-terminal domain of a subfamily of Na+ /H+ antiporter existed in bacteria and archea . Na+/H+ exchange proteins eject protons from cells, effectively eliminating excess acid from actively metabolising cells. Na+ /H+ exchange activity is also crucial...; Region: Na_H_Antiporter_C; cd01988
755178008471	Ligand Binding Site [chemical binding]; other site
755178008472	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
755178008473	Ligand Binding Site [chemical binding]; other site
755178008474	Domain of unknown function (DUF309); Region: DUF309; pfam03745
755178008475	Uncharacterized conserved protein [Function unknown]; Region: COG2006
755178008476	Domain of unknown function (DUF362); Region: DUF362; pfam04015
755178008477	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
755178008478	Domain of unknown function DUF20; Region: UPF0118; pfam01594
755178008479	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
755178008480	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
755178008481	dimer interface [polypeptide binding]; other site
755178008482	pyridoxal 5'-phosphate binding site [chemical binding]; other site
755178008483	catalytic residue [active]
755178008484	DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]; Region: DnaJ; COG0484
755178008485	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
755178008486	HSP70 interaction site [polypeptide binding]; other site
755178008487	Protein of unknown function (DUF3148); Region: DUF3148; pfam11347
755178008488	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
755178008489	PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH  (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme.  DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488
755178008490	aromatic arch; other site
755178008491	DCoH dimer interaction site [polypeptide binding]; other site
755178008492	DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site
755178008493	DCoH tetramer interaction site [polypeptide binding]; other site
755178008494	substrate binding site [chemical binding]; other site
755178008495	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112
755178008496	tRNA-guanine family transglycosylase; Region: tgt_general; TIGR00449
755178008497	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
755178008498	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
755178008499	DNA polymerase III subunit alpha; Reviewed; Region: PRK07373
755178008500	Hint (Hedgehog/Intein) domain C-terminal region; Region: HintC; smart00305
755178008501	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
755178008502	generic binding surface I; other site
755178008503	generic binding surface II; other site
755178008504	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
755178008505	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
755178008506	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
755178008507	TrkA-N domain; Region: TrkA_N; pfam02254
755178008508	TrkA-C domain; Region: TrkA_C; pfam02080
755178008509	A bacterial subgroup of the C-type lectin-like (CTLD) domain; a subgroup of bacterial protein domains homologous to the carbohydrate-recognition domains (CRDs) of the C-type lectins; Region: CLECT_VCBS; cd03603
755178008510	ligand binding surface [chemical binding]; other site
755178008511	Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193
755178008512	Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907
755178008513	heme binding site [chemical binding]; other site
755178008514	ferroxidase pore; other site
755178008515	ferroxidase diiron center [ion binding]; other site
755178008516	Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193
755178008517	Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907
755178008518	heme binding site [chemical binding]; other site
755178008519	ferroxidase pore; other site
755178008520	ferroxidase diiron center [ion binding]; other site
755178008521	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
755178008522	3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
755178008523	substrate binding site [chemical binding]; other site
755178008524	ligand binding site [chemical binding]; other site
755178008525	Response regulator receiver domain; Region: Response_reg; pfam00072
755178008526	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
755178008527	active site
755178008528	phosphorylation site [posttranslational modification]
755178008529	intermolecular recognition site; other site
755178008530	dimerization interface [polypeptide binding]; other site
755178008531	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
755178008532	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
755178008533	metal binding site [ion binding]; metal-binding site
755178008534	active site
755178008535	I-site; other site
755178008536	Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427
755178008537	NQR2, RnfD, RnfE family; Region: NQR2_RnfD_RnfE; cl00779
755178008538	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4402
755178008539	molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317
755178008540	MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503
755178008541	GTP binding site; other site
755178008542	Protein of unknown function (DUF2555); Region: DUF2555; pfam10742
755178008543	bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579
755178008544	Flavoprotein; Region: Flavoprotein; pfam02441
755178008545	DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127
755178008546	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
755178008547	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
755178008548	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
755178008549	Walker A/P-loop; other site
755178008550	ATP binding site [chemical binding]; other site
755178008551	Q-loop/lid; other site
755178008552	ABC transporter signature motif; other site
755178008553	Walker B; other site
755178008554	D-loop; other site
755178008555	H-loop/switch region; other site
755178008556	bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
755178008557	RNA/DNA hybrid binding site [nucleotide binding]; other site
755178008558	active site
755178008559	Protein of unknown function (DUF3529); Region: DUF3529; pfam12046
755178008560	Inward rectifier potassium channel; Region: IRK; pfam01007
755178008561	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
755178008562	Permease; Region: Permease; cl00510
755178008563	Tetratricopeptide repeat; Region: TPR_16; pfam13432
755178008564	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
755178008565	binding surface
755178008566	TPR motif; other site
755178008567	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
755178008568	dimerization interface [polypeptide binding]; other site
755178008569	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
755178008570	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
755178008571	dimer interface [polypeptide binding]; other site
755178008572	putative CheW interface [polypeptide binding]; other site
755178008573	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256
755178008574	Response regulator receiver domain; Region: Response_reg; pfam00072
755178008575	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
755178008576	active site
755178008577	phosphorylation site [posttranslational modification]
755178008578	intermolecular recognition site; other site
755178008579	dimerization interface [polypeptide binding]; other site
755178008580	hopanoid biosynthesis associated radical SAM protein HpnH; Region: HpnH; TIGR03470
755178008581	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
755178008582	FeS/SAM binding site; other site
755178008583	Domain of unknown function (DUF3463); Region: DUF3463; pfam11946
755178008584	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
755178008585	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
755178008586	hinge; other site
755178008587	active site
755178008588	Holliday junction resolvase-like protein; Reviewed; Region: PRK00109
755178008589	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
755178008590	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
755178008591	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
755178008592	Probable transposase; Region: OrfB_IS605; pfam01385
755178008593	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
755178008594	Piccolo Zn-finger; Region: zf-piccolo; pfam05715
755178008595	hydrolase, alpha/beta fold family protein; Region: PLN02824
755178008596	dihydroxy-acid dehydratase; Provisional; Region: PRK00911
755178008597	GTP-binding protein Der; Reviewed; Region: PRK00093
755178008598	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
755178008599	G1 box; other site
755178008600	GTP/Mg2+ binding site [chemical binding]; other site
755178008601	Switch I region; other site
755178008602	G2 box; other site
755178008603	Switch II region; other site
755178008604	G3 box; other site
755178008605	G4 box; other site
755178008606	G5 box; other site
755178008607	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
755178008608	G1 box; other site
755178008609	GTP/Mg2+ binding site [chemical binding]; other site
755178008610	Switch I region; other site
755178008611	G2 box; other site
755178008612	G3 box; other site
755178008613	Switch II region; other site
755178008614	G4 box; other site
755178008615	G5 box; other site
755178008616	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
755178008617	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
755178008618	Probable transposase; Region: OrfB_IS605; pfam01385
755178008619	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
755178008620	4-hydroxythreonine-4-phosphate dehydrogenase; Provisional; Region: pdxA; PRK02746
755178008621	4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743
755178008622	This domain is the catalytic domain of ribonuclease II; Region: RNB; smart00955
755178008623	RNB domain; Region: RNB; pfam00773
755178008624	The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731
755178008625	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
755178008626	substrate binding site [chemical binding]; other site
755178008627	glutamase interaction surface [polypeptide binding]; other site
755178008628	HEAT repeats; Region: HEAT_2; pfam13646
755178008629	dihydroorotase; Provisional; Region: PRK07575
755178008630	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
755178008631	Dihydroorotase (DHOase), subgroup IIb; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This group contains the archeal members of the DHOase family; Region: DHOase_IIb; cd01318
755178008632	active site
755178008633	Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954
755178008634	Uncharacterized conserved protein [Function unknown]; Region: COG1262
755178008635	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
755178008636	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
755178008637	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
755178008638	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
755178008639	Tetratricopeptide repeat; Region: TPR_16; pfam13432
755178008640	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
755178008641	TPR motif; other site
755178008642	Protein of unknown function (DUF3146); Region: DUF3146; pfam11344
755178008643	PAS domain S-box; Region: sensory_box; TIGR00229
755178008644	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
755178008645	putative active site [active]
755178008646	heme pocket [chemical binding]; other site
755178008647	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
755178008648	GAF domain; Region: GAF; pfam01590
755178008649	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
755178008650	GAF domain; Region: GAF; pfam01590
755178008651	PAS domain S-box; Region: sensory_box; TIGR00229
755178008652	Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086
755178008653	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
755178008654	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
755178008655	dimer interface [polypeptide binding]; other site
755178008656	phosphorylation site [posttranslational modification]
755178008657	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
755178008658	ATP binding site [chemical binding]; other site
755178008659	Mg2+ binding site [ion binding]; other site
755178008660	G-X-G motif; other site
755178008661	Response regulator receiver domain; Region: Response_reg; pfam00072
755178008662	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
755178008663	active site
755178008664	phosphorylation site [posttranslational modification]
755178008665	intermolecular recognition site; other site
755178008666	dimerization interface [polypeptide binding]; other site
755178008667	Response regulator receiver domain; Region: Response_reg; pfam00072
755178008668	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
755178008669	active site
755178008670	phosphorylation site [posttranslational modification]
755178008671	intermolecular recognition site; other site
755178008672	dimerization interface [polypeptide binding]; other site
755178008673	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
755178008674	putative binding surface; other site
755178008675	active site
755178008676	5-carboxymethyl-2-hydroxymuconate isomerase (CHMI) is a trimeric enzyme catalyzing the isomerization of the unsaturated ketone 5-(carboxymethyl)-2-hydroxymuconate to 5-(carboxymethyl)-2-oxo-3-hexene-1,6-dionate. This is one step in the...; Region: CHMI; cl01268
755178008677	Domain of unknown function (DUF4033); Region: DUF4033; pfam13225
755178008678	Protein of unknown function (DUF3285); Region: DUF3285; pfam11688
755178008679	integral membrane protein MviN; Region: mviN; TIGR01695
755178008680	MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123
755178008681	Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219
755178008682	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
755178008683	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
755178008684	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
755178008685	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
755178008686	dimer interface [polypeptide binding]; other site
755178008687	phosphorylation site [posttranslational modification]
755178008688	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
755178008689	ATP binding site [chemical binding]; other site
755178008690	Mg2+ binding site [ion binding]; other site
755178008691	G-X-G motif; other site
755178008692	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
755178008693	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
755178008694	active site
755178008695	phosphorylation site [posttranslational modification]
755178008696	dimerization interface [polypeptide binding]; other site
755178008697	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
755178008698	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
755178008699	active site
755178008700	metal binding site [ion binding]; metal-binding site
755178008701	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
755178008702	S-adenosylmethionine binding site [chemical binding]; other site
755178008703	Protein of unknown function (DUF3611); Region: DUF3611; pfam12263
755178008704	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
755178008705	nucleoside/Zn binding site; other site
755178008706	dimer interface [polypeptide binding]; other site
755178008707	catalytic motif [active]
755178008708	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
755178008709	aminoethylphosphonate catabolism associated LysR family transcriptional regulator; Region: phn_lysR; TIGR03339
755178008710	The C-terminal substrate binding of LysR-type transcriptional regulator (CbbR) of RubisCO operon, which is involved in the carbon dioxide fixation, contains the type 2 periplasmic binding fold; Region: PBP2_CbbR_RubisCO_like; cd08419
755178008711	putative dimerization interface [polypeptide binding]; other site
755178008712	NAD(P)H-quinone oxidoreductase subunit F; Validated; Region: PRK07390
755178008713	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
755178008714	NAD(P)H-quinone oxidoreductase subunit D4; Validated; Region: PRK06473
755178008715	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
755178008716	CO2 hydration protein (ChpXY); Region: ChpXY; cl10905
755178008717	Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335
755178008718	Fasciclin domain; Region: Fasciclin; pfam02469
755178008719	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635
755178008720	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
755178008721	catalytic residue [active]
755178008722	MASE1; Region: MASE1; cl17823
755178008723	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
755178008724	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
755178008725	metal binding site [ion binding]; metal-binding site
755178008726	active site
755178008727	I-site; other site
755178008728	DNA-directed RNA polymerase subunit gamma; Provisional; Region: rpoC1; PRK02625
755178008729	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
755178008730	RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663
755178008731	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
755178008732	glycogen synthase; Provisional; Region: glgA; PRK00654
755178008733	This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791
755178008734	ADP-binding pocket [chemical binding]; other site
755178008735	homodimer interface [polypeptide binding]; other site
755178008736	L-aspartate oxidase; Provisional; Region: PRK07395
755178008737	L-aspartate oxidase; Provisional; Region: PRK06175
755178008738	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
755178008739	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_6; cd06154
755178008740	homotrimer interaction site [polypeptide binding]; other site
755178008741	putative active site [active]
755178008742	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364
755178008743	Cyanobacterial and plant NDH-1 subunit O; Region: NdhO; pfam11910
755178008744	cytosine deaminase-like protein; Validated; Region: PRK07583
755178008745	Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293
755178008746	active site
755178008747	Protein of unknown function (DUF1049); Region: DUF1049; pfam06305
755178008748	glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14096
755178008749	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
755178008750	active site
755178008751	dimer interface [polypeptide binding]; other site
755178008752	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
755178008753	dimer interface [polypeptide binding]; other site
755178008754	active site
755178008755	Protein of unknown function (DUF1257); Region: DUF1257; pfam06868
755178008756	Ycf46; Provisional; Region: ycf46; CHL00195
755178008757	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
755178008758	Walker A motif; other site
755178008759	ATP binding site [chemical binding]; other site
755178008760	Walker B motif; other site
755178008761	arginine finger; other site
755178008762	Predicted nuclease of the RNAse H fold, HicB family [General    function prediction only]; Region: HicB; COG4226
755178008763	Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602
755178008764	putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322
755178008765	Cupin domain; Region: Cupin_2; pfam07883
755178008766	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
755178008767	C-5 cytosine-specific DNA methylase; Region: DNA_methylase; pfam00145
755178008768	cofactor binding site; other site
755178008769	DNA binding site [nucleotide binding]
755178008770	substrate interaction site [chemical binding]; other site
755178008771	Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270
755178008772	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
755178008773	cofactor binding site; other site
755178008774	DNA binding site [nucleotide binding]
755178008775	substrate interaction site [chemical binding]; other site
755178008776	Staphylococcal nuclease homologues; Region: SNc; smart00318
755178008777	Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140
755178008778	Catalytic site; other site
755178008779	30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270
755178008780	Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290
755178008781	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284
755178008782	Qi binding site; other site
755178008783	intrachain domain interface; other site
755178008784	interchain domain interface [polypeptide binding]; other site
755178008785	heme bH binding site [chemical binding]; other site
755178008786	heme bL binding site [chemical binding]; other site
755178008787	Qo binding site; other site
755178008788	Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290
755178008789	Cytochrome b(C-terminus)/b6/petD:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cd00290
755178008790	interchain domain interface [polypeptide binding]; other site
755178008791	intrachain domain interface; other site
755178008792	Qi binding site; other site
755178008793	Qo binding site; other site
755178008794	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
755178008795	S-adenosylmethionine binding site [chemical binding]; other site
755178008796	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
755178008797	Peptidase family M23; Region: Peptidase_M23; pfam01551
755178008798	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
755178008799	intersubunit interface [polypeptide binding]; other site
755178008800	active site
755178008801	zinc binding site [ion binding]; other site
755178008802	Na+ binding site [ion binding]; other site
755178008803	CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916
755178008804	dimer interface [polypeptide binding]; other site
755178008805	PIN domain; Region: PIN_2; cl17859
755178008806	cobaltochelatase subunit; Region: Cob-chelat-sub; TIGR02442
755178008807	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
755178008808	Walker A motif; other site
755178008809	ATP binding site [chemical binding]; other site
755178008810	Walker B motif; other site
755178008811	arginine finger; other site
755178008812	Magnesium chelatase: Mg-chelatase catalyses the insertion of Mg into protoporphyrin IX (Proto). In chlorophyll biosynthesis, insertion of Mg2+ into protoporphyrin IX is catalysed by magnesium chelatase in an ATP-dependent reaction. Magnesium chelatase is...; Region: vWA_Magnesium_chelatase; cd01451
755178008813	metal ion-dependent adhesion site (MIDAS); other site
755178008814	Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026
755178008815	Protein of unknown function (DUF433); Region: DUF433; pfam04255
755178008816	Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681
755178008817	photosystem II reaction center I protein I; Provisional; Region: psbI; PRK02655
755178008818	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
755178008819	2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654
755178008820	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
755178008821	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
755178008822	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
755178008823	catalytic residue [active]
755178008824	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
755178008825	putative binding surface; other site
755178008826	active site
755178008827	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
755178008828	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
755178008829	Cupin domain; Region: Cupin_2; pfam07883
755178008830	GTPase CgtA; Reviewed; Region: obgE; PRK12299
755178008831	GTP1/OBG; Region: GTP1_OBG; pfam01018
755178008832	Obg GTPase; Region: Obg; cd01898
755178008833	G1 box; other site
755178008834	GTP/Mg2+ binding site [chemical binding]; other site
755178008835	Switch I region; other site
755178008836	G2 box; other site
755178008837	G3 box; other site
755178008838	Switch II region; other site
755178008839	G4 box; other site
755178008840	G5 box; other site
755178008841	Pleckstrin homology (PH)-like domains in bacteria (PHb); Region: PH-like_bacteria; cd13225
755178008842	pentamer interface [polypeptide binding]; other site
755178008843	dodecaamer interface [polypeptide binding]; other site
755178008844	YvbH-like oligomerisation region; Region: YvbH_ext; pfam11724
755178008845	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
755178008846	S-adenosylmethionine binding site [chemical binding]; other site
755178008847	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
755178008848	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
755178008849	substrate binding pocket [chemical binding]; other site
755178008850	membrane-bound complex binding site; other site
755178008851	hinge residues; other site
755178008852	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
755178008853	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
755178008854	dimer interface [polypeptide binding]; other site
755178008855	conserved gate region; other site
755178008856	putative PBP binding loops; other site
755178008857	ABC-ATPase subunit interface; other site
755178008858	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
755178008859	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
755178008860	Walker A/P-loop; other site
755178008861	ATP binding site [chemical binding]; other site
755178008862	Q-loop/lid; other site
755178008863	ABC transporter signature motif; other site
755178008864	Walker B; other site
755178008865	D-loop; other site
755178008866	H-loop/switch region; other site
755178008867	Predicted double-stranded RNA/RNA-DNA hybrid binding protein [General function prediction only]; Region: COG3341
755178008868	Caulimovirus viroplasmin; Region: Cauli_VI; pfam01693
755178008869	RNase H is an endonuclease that cleaves the RNA strand of an RNA/DNA hybrid in a sequence non-specific manner; Region: RNase_H; cd06222
755178008870	active site
755178008871	RNA/DNA hybrid binding site [nucleotide binding]; other site
755178008872	GTP-binding protein YchF; Reviewed; Region: PRK09601
755178008873	YchF GTPase; Region: YchF; cd01900
755178008874	G1 box; other site
755178008875	GTP/Mg2+ binding site [chemical binding]; other site
755178008876	Switch I region; other site
755178008877	G2 box; other site
755178008878	Switch II region; other site
755178008879	G3 box; other site
755178008880	G4 box; other site
755178008881	G5 box; other site
755178008882	TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
755178008883	Glucosylceramide synthase catalyzes the first glycosylation step of glycosphingolipid synthesis; Region: Glucosylceramide_synthase; cd02520
755178008884	ligand binding site; other site
755178008885	Glycosyl transferase family 21; Region: Glyco_transf_21; pfam13506
755178008886	Class II bacteriocin; Region: Bacteriocin_II; pfam01721
755178008887	Curli production assembly/transport component CsgG; Region: CsgG; pfam03783
755178008888	ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575
755178008889	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
755178008890	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
755178008891	Cytochrome c; Region: Cytochrom_C; pfam00034
755178008892	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
755178008893	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
755178008894	Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191
755178008895	Predicted methyltransferases [General function prediction only]; Region: COG0313
755178008896	Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648
755178008897	putative SAM binding site [chemical binding]; other site
755178008898	putative homodimer interface [polypeptide binding]; other site
755178008899	50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359
755178008900	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
755178008901	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
755178008902	Probable transposase; Region: OrfB_IS605; pfam01385
755178008903	Protein of unknown function (DUF4079); Region: DUF4079; pfam13301
755178008904	Protein of unknown function (DUF4079); Region: DUF4079; pfam13301
755178008905	Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151
755178008906	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
755178008907	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
755178008908	dimer interface [polypeptide binding]; other site
755178008909	phosphorylation site [posttranslational modification]
755178008910	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
755178008911	ATP binding site [chemical binding]; other site
755178008912	Mg2+ binding site [ion binding]; other site
755178008913	G-X-G motif; other site
755178008914	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
755178008915	Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404
755178008916	active site
755178008917	catalytic residues [active]
755178008918	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
755178008919	metal-binding site [ion binding]
755178008920	Serine acetyltransferase [Amino acid transport and metabolism]; Region: CysE; COG1045
755178008921	Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762
755178008922	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
755178008923	trimer interface [polypeptide binding]; other site
755178008924	active site
755178008925	substrate binding site [chemical binding]; other site
755178008926	CoA binding site [chemical binding]; other site
755178008927	acetylornithine aminotransferase; Provisional; Region: PRK02627
755178008928	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
755178008929	inhibitor-cofactor binding pocket; inhibition site
755178008930	pyridoxal 5'-phosphate binding site [chemical binding]; other site
755178008931	catalytic residue [active]
755178008932	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
755178008933	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
755178008934	glyceraldehyde-3-phosphate dehydrogenase; Reviewed; Region: PRK07403
755178008935	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044
755178008936	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
755178008937	Clp protease; Region: CLP_protease; pfam00574
755178008938	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
755178008939	oligomer interface [polypeptide binding]; other site
755178008940	active site residues [active]
755178008941	Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740
755178008942	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
755178008943	oligomer interface [polypeptide binding]; other site
755178008944	active site residues [active]
755178008945	Domain of unknown function (DUF1816); Region: DUF1816; pfam08846
755178008946	Protein of function (DUF2518); Region: DUF2518; pfam10726
755178008947	adaptive-response sensory kinase; Validated; Region: PRK09303
755178008948	KaiB-like family; composed of the circadian clock proteins, KaiB and the N-terminal KaiB-like sensory domain of SasA. KaiB is an essential protein in maintaining circadian rhythm. It was originally discovered from the cyanobacterium Synechococcus as part...; Region: KaiB_like; cd02978
755178008949	tetramer interface [polypeptide binding]; other site
755178008950	dimer interface [polypeptide binding]; other site
755178008951	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
755178008952	dimer interface [polypeptide binding]; other site
755178008953	phosphorylation site [posttranslational modification]
755178008954	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
755178008955	ATP binding site [chemical binding]; other site
755178008956	Mg2+ binding site [ion binding]; other site
755178008957	G-X-G motif; other site
755178008958	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
755178008959	binding surface
755178008960	TPR motif; other site
755178008961	TPR repeat; Region: TPR_11; pfam13414
755178008962	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
755178008963	TPR motif; other site
755178008964	binding surface
755178008965	TPR repeat; Region: TPR_11; pfam13414
755178008966	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
755178008967	binding surface
755178008968	TPR repeat; Region: TPR_11; pfam13414
755178008969	TPR motif; other site
755178008970	Tetratricopeptide repeat; Region: TPR_16; pfam13432
755178008971	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
755178008972	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
755178008973	ABC-ATPase subunit  interface; other site
755178008974	dimer interface [polypeptide binding]; other site
755178008975	putative PBP binding regions; other site
755178008976	TPR repeat; Region: TPR_11; pfam13414
755178008977	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
755178008978	binding surface
755178008979	TPR motif; other site
755178008980	Tetratricopeptide repeat; Region: TPR_12; pfam13424
755178008981	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
755178008982	TPR motif; other site
755178008983	Tetratricopeptide repeat; Region: TPR_12; pfam13424
755178008984	binding surface
755178008985	Tetratricopeptide repeat; Region: TPR_12; pfam13424
755178008986	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
755178008987	binding surface
755178008988	TPR motif; other site
755178008989	Tetratricopeptide repeat; Region: TPR_12; pfam13424
755178008990	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
755178008991	TPR motif; other site
755178008992	Tetratricopeptide repeat; Region: TPR_12; pfam13424
755178008993	binding surface
755178008994	TPR repeat; Region: TPR_11; pfam13414
755178008995	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
755178008996	binding surface
755178008997	TPR motif; other site
755178008998	CHAT domain; Region: CHAT; pfam12770
755178008999	Psb28 protein; Region: Psb28; cl04326
755178009000	proline/glycine betaine transporter; Provisional; Region: PRK10642
755178009001	heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525
755178009002	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
755178009003	Soluble P-type ATPase [General function prediction only]; Region: COG4087
755178009004	Plasmid maintenance system killer protein; Region: Plasmid_killer; cl01422
755178009005	Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093
755178009006	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
755178009007	non-specific DNA binding site [nucleotide binding]; other site
755178009008	salt bridge; other site
755178009009	sequence-specific DNA binding site [nucleotide binding]; other site
755178009010	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
755178009011	active site
755178009012	NTP binding site [chemical binding]; other site
755178009013	metal binding triad [ion binding]; metal-binding site
755178009014	antibiotic binding site [chemical binding]; other site
755178009015	Protein of unknown function DUF86; Region: DUF86; cl01031
755178009016	FeoA domain; Region: FeoA; pfam04023
755178009017	Homeodomain-like domain; Region: HTH_23; pfam13384
755178009018	Winged helix-turn helix; Region: HTH_29; pfam13551
755178009019	Homeodomain-like domain; Region: HTH_32; pfam13565
755178009020	Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370
755178009021	Nucleoside recognition; Region: Gate; pfam07670
755178009022	Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664
755178009023	Nucleoside recognition; Region: Gate; pfam07670
755178009024	Ferrous iron transport protein B; Region: FeoB_N; pfam02421
755178009025	Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879
755178009026	G1 box; other site
755178009027	GTP/Mg2+ binding site [chemical binding]; other site
755178009028	Switch I region; other site
755178009029	G2 box; other site
755178009030	G3 box; other site
755178009031	Switch II region; other site
755178009032	G4 box; other site
755178009033	G5 box; other site
755178009034	Protein of unknown function (DUF1499); Region: DUF1499; cl01841
755178009035	Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109
755178009036	This PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily and is found in both archaea and bacteria. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible...; Region: PGM_like2; cd05800
755178009037	active site
755178009038	substrate binding site [chemical binding]; other site
755178009039	metal binding site [ion binding]; metal-binding site
755178009040	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
755178009041	Beta-lactamase superfamily domain; Region: Lactamase_B_3; pfam13483
755178009042	NMT1-like family; Region: NMT1_2; pfam13379
755178009043	NMT1/THI5 like; Region: NMT1; pfam09084
755178009044	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
755178009045	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
755178009046	dimer interface [polypeptide binding]; other site
755178009047	conserved gate region; other site
755178009048	putative PBP binding loops; other site
755178009049	ABC-ATPase subunit interface; other site
755178009050	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
755178009051	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
755178009052	Walker A/P-loop; other site
755178009053	ATP binding site [chemical binding]; other site
755178009054	Q-loop/lid; other site
755178009055	ABC transporter signature motif; other site
755178009056	Walker B; other site
755178009057	D-loop; other site
755178009058	H-loop/switch region; other site
755178009059	Protein of unknown function (DUF1348); Region: DUF1348; pfam07080
755178009060	SnoaL-like domain; Region: SnoaL_2; pfam12680
755178009061	cyanate hydratase; Validated; Region: PRK02866
755178009062	Cyanase C-terminal domain. Cyanase (Cyanate lyase) is responsible for the hydrolysis of cyanate.  It catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide. This allows organisms that possess the enzyme to overcome the...; Region: Cyanase_C; cd00559
755178009063	oligomer interface [polypeptide binding]; other site
755178009064	active site
755178009065	excinuclease ABC subunit B; Provisional; Region: PRK05298
755178009066	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
755178009067	ATP binding site [chemical binding]; other site
755178009068	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
755178009069	nucleotide binding region [chemical binding]; other site
755178009070	ATP-binding site [chemical binding]; other site
755178009071	Ultra-violet resistance protein B; Region: UvrB; pfam12344
755178009072	UvrB/uvrC motif; Region: UVR; pfam02151
755178009073	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876
755178009074	D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557
755178009075	Protein kinase domain; Region: Pkinase; pfam00069
755178009076	Catalytic domain of Protein Kinases; Region: PKc; cd00180
755178009077	active site
755178009078	ATP binding site [chemical binding]; other site
755178009079	substrate binding site [chemical binding]; other site
755178009080	activation loop (A-loop); other site
755178009081	Bacterial SH3 domain homologues; Region: SH3b; smart00287
755178009082	CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cd09652
755178009083	heat shock protein 90; Provisional; Region: PRK05218
755178009084	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
755178009085	ATP binding site [chemical binding]; other site
755178009086	Mg2+ binding site [ion binding]; other site
755178009087	G-X-G motif; other site
755178009088	Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018
755178009089	tandem repeat interface [polypeptide binding]; other site
755178009090	signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706
755178009091	oligomer interface [polypeptide binding]; other site
755178009092	active site residues [active]
755178009093	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
755178009094	signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706
755178009095	tandem repeat interface [polypeptide binding]; other site
755178009096	oligomer interface [polypeptide binding]; other site
755178009097	active site residues [active]
755178009098	Bestrophin, RFP-TM, chloride channel; Region: Bestrophin; cl01544
755178009099	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
755178009100	Catalytic domain of Protein Kinases; Region: PKc; cd00180
755178009101	active site
755178009102	ATP binding site [chemical binding]; other site
755178009103	substrate binding site [chemical binding]; other site
755178009104	activation loop (A-loop); other site
755178009105	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
755178009106	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
755178009107	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
755178009108	Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982
755178009109	Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615
755178009110	homodimer interface [polypeptide binding]; other site
755178009111	pyridoxal 5'-phosphate binding site [chemical binding]; other site
755178009112	catalytic residue [active]
755178009113	Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711
755178009114	GAF domain; Region: GAF_3; pfam13492
755178009115	Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208
755178009116	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
755178009117	HetN oxidoreductase-like, classical (c) SDR; Region: HetN_like_SDR_c; cd08932
755178009118	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07666
755178009119	putative NAD(P) binding site [chemical binding]; other site
755178009120	active site
755178009121	ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549
755178009122	ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178
755178009123	ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223
755178009124	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
755178009125	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283
755178009126	putative NAD(P) binding site [chemical binding]; other site
755178009127	putative substrate binding site [chemical binding]; other site
755178009128	catalytic Zn binding site [ion binding]; other site
755178009129	structural Zn binding site [ion binding]; other site
755178009130	dimer interface [polypeptide binding]; other site
755178009131	rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565
755178009132	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
755178009133	Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999
755178009134	HlyD family secretion protein; Region: HlyD_3; pfam13437
755178009135	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
755178009136	Protein export membrane protein; Region: SecD_SecF; cl14618
755178009137	Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577
755178009138	Carbon dioxide concentrating mechanism (CcmK); Bacterial Micro-Compartment (BCM) domain; Region: BMC_CcmK; cd07057
755178009139	Hexamer interface [polypeptide binding]; other site
755178009140	Hexagonal pore residue; other site
755178009141	Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577
755178009142	Bacterial Micro-Compartment (BMC) domain; Region: BMC; cl01982
755178009143	Hexamer interface [polypeptide binding]; other site
755178009144	Hexagonal pore residue; other site
755178009145	NAD(P) transhydrogenase subunit alpha; Provisional; Region: pntA; PRK09424
755178009146	Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304
755178009147	ligand binding site [chemical binding]; other site
755178009148	homodimer interface [polypeptide binding]; other site
755178009149	NAD(P) binding site [chemical binding]; other site
755178009150	trimer interface B [polypeptide binding]; other site
755178009151	trimer interface A [polypeptide binding]; other site
755178009152	Domain of unknown function (DUF3814); Region: DUF3814; pfam12769
755178009153	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
755178009154	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814
755178009155	S23 ribosomal protein; Region: Ribosomal_S23p; cl05287
755178009156	four helix bundle protein; Region: TIGR02436
755178009157	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
755178009158	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
755178009159	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
755178009160	Ligand Binding Site [chemical binding]; other site
755178009161	AAA ATPase domain; Region: AAA_16; pfam13191
755178009162	NB-ARC domain; Region: NB-ARC; pfam00931
755178009163	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
755178009164	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
755178009165	structural tetrad; other site
755178009166	FOG: WD40 repeat [General function prediction only]; Region: COG2319
755178009167	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
755178009168	structural tetrad; other site
755178009169	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
755178009170	Probable transposase; Region: OrfB_IS605; pfam01385
755178009171	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
755178009172	Transposase IS200 like; Region: Y1_Tnp; pfam01797
755178009173	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
755178009174	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
755178009175	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1649
755178009176	Uncharacterized BCR, COG1649; Region: DUF187; pfam02638
755178009177	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
755178009178	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
755178009179	dimer interface [polypeptide binding]; other site
755178009180	anticodon binding site; other site
755178009181	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
755178009182	homodimer interface [polypeptide binding]; other site
755178009183	motif 1; other site
755178009184	active site
755178009185	motif 2; other site
755178009186	GAD domain; Region: GAD; pfam02938
755178009187	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
755178009188	active site
755178009189	motif 3; other site
755178009190	Protein of unknown function (DUF1350); Region: DUF1350; pfam07082
755178009191	Iron-sulfur cluster assembly accessory protein; Region: TIGR00049
755178009192	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
755178009193	putative active site [active]
755178009194	heme pocket [chemical binding]; other site
755178009195	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
755178009196	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
755178009197	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
755178009198	dimer interface [polypeptide binding]; other site
755178009199	phosphorylation site [posttranslational modification]
755178009200	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
755178009201	ATP binding site [chemical binding]; other site
755178009202	Mg2+ binding site [ion binding]; other site
755178009203	G-X-G motif; other site
755178009204	Response regulator receiver domain; Region: Response_reg; pfam00072
755178009205	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
755178009206	active site
755178009207	phosphorylation site [posttranslational modification]
755178009208	intermolecular recognition site; other site
755178009209	dimerization interface [polypeptide binding]; other site
755178009210	DNA gyrase subunit B; Validated; Region: gyrB; PRK05644
755178009211	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
755178009212	Mg2+ binding site [ion binding]; other site
755178009213	G-X-G motif; other site
755178009214	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
755178009215	anchoring element; other site
755178009216	dimer interface [polypeptide binding]; other site
755178009217	ATP binding site [chemical binding]; other site
755178009218	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
755178009219	active site
755178009220	putative metal-binding site [ion binding]; other site
755178009221	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
755178009222	lipoyl synthase; Provisional; Region: PRK05481
755178009223	Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding); Region: MPN_like; cd08070
755178009224	MPN+ (JAMM) motif; other site
755178009225	Zinc-binding site [ion binding]; other site
755178009226	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
755178009227	putative active site [active]
755178009228	phycocyanin, alpha subunit; Region: phycocy_alpha; TIGR01338
755178009229	phycocyanin, beta subunit; Region: phycocy_beta; TIGR01339
755178009230	PIN domain of the VapC-like Sll0205 protein and homologs; Region: PIN_Sll0205; cd09872
755178009231	putative active site [active]
755178009232	Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118
755178009233	tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054
755178009234	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
755178009235	50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618
755178009236	Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495
755178009237	5S rRNA interface [nucleotide binding]; other site
755178009238	CTC domain interface [polypeptide binding]; other site
755178009239	L16 interface [polypeptide binding]; other site
755178009240	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
755178009241	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
755178009242	GDP-binding site [chemical binding]; other site
755178009243	ACT binding site; other site
755178009244	IMP binding site; other site
755178009245	Domain of unknown function DUF59; Region: DUF59; pfam01883
755178009246	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489
755178009247	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
755178009248	Walker A motif; other site
755178009249	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
755178009250	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
755178009251	ATP binding site [chemical binding]; other site
755178009252	Mg2+ binding site [ion binding]; other site
755178009253	G-X-G motif; other site
755178009254	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
755178009255	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
755178009256	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
755178009257	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
755178009258	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
755178009259	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
755178009260	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
755178009261	GMP synthase; Reviewed; Region: guaA; PRK00074
755178009262	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
755178009263	AMP/PPi binding site [chemical binding]; other site
755178009264	candidate oxyanion hole; other site
755178009265	catalytic triad [active]
755178009266	potential glutamine specificity residues [chemical binding]; other site
755178009267	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
755178009268	ATP Binding subdomain [chemical binding]; other site
755178009269	Ligand Binding sites [chemical binding]; other site
755178009270	Dimerization subdomain; other site
755178009271	cobalt-precorrin-8X methylmutase; Validated; Region: cbiC; cl00913
755178009272	Precorrin-8X methylmutase; Region: CbiC; pfam02570
755178009273	Response regulator receiver domain; Region: Response_reg; pfam00072
755178009274	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
755178009275	active site
755178009276	phosphorylation site [posttranslational modification]
755178009277	intermolecular recognition site; other site
755178009278	dimerization interface [polypeptide binding]; other site
755178009279	PAS fold; Region: PAS_4; pfam08448
755178009280	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
755178009281	putative active site [active]
755178009282	heme pocket [chemical binding]; other site
755178009283	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
755178009284	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
755178009285	metal binding site [ion binding]; metal-binding site
755178009286	active site
755178009287	I-site; other site
755178009288	ammonium transporter; Region: amt; TIGR00836
755178009289	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
755178009290	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
755178009291	dimer interface [polypeptide binding]; other site
755178009292	phosphorylation site [posttranslational modification]
755178009293	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
755178009294	ATP binding site [chemical binding]; other site
755178009295	Mg2+ binding site [ion binding]; other site
755178009296	G-X-G motif; other site
755178009297	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
755178009298	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
755178009299	active site
755178009300	phosphorylation site [posttranslational modification]
755178009301	intermolecular recognition site; other site
755178009302	dimerization interface [polypeptide binding]; other site
755178009303	Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312
755178009304	Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754
755178009305	MoaE interaction surface [polypeptide binding]; other site
755178009306	MoeB interaction surface [polypeptide binding]; other site
755178009307	thiocarboxylated glycine; other site
755178009308	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
755178009309	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
755178009310	P-loop; other site
755178009311	Magnesium ion binding site [ion binding]; other site
755178009312	Uncharacterized conserved protein [Function unknown]; Region: COG0398
755178009313	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
755178009314	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
755178009315	Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355
755178009316	putative ligand binding site [chemical binding]; other site
755178009317	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
755178009318	This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802
755178009319	putative ADP-binding pocket [chemical binding]; other site
755178009320	photosystem II protein K; Region: psbK; CHL00047
755178009321	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
755178009322	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
755178009323	phosphopeptide binding site; other site
755178009324	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
755178009325	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
755178009326	metal binding site [ion binding]; metal-binding site
755178009327	active site
755178009328	I-site; other site
755178009329	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
755178009330	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
755178009331	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_20; cd08519
755178009332	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
755178009333	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
755178009334	dimer interface [polypeptide binding]; other site
755178009335	active site
755178009336	glycine-pyridoxal phosphate binding site [chemical binding]; other site
755178009337	folate binding site [chemical binding]; other site
755178009338	metal-binding heat shock protein; Provisional; Region: PRK00016
755178009339	ketol-acid reductoisomerase; Provisional; Region: PRK05479
755178009340	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991
755178009341	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
755178009342	rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186
755178009343	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032
755178009344	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
755178009345	Anion-transporting ATPase; Region: ArsA_ATPase; pfam02374
755178009346	ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
755178009347	P loop; other site
755178009348	Nucleotide binding site [chemical binding]; other site
755178009349	DTAP/Switch II; other site
755178009350	Switch I; other site
755178009351	ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
755178009352	Predicted membrane-associated HD superfamily hydrolase [General function prediction only]; Region: COG1480
755178009353	7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698
755178009354	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
755178009355	Zn2+ binding site [ion binding]; other site
755178009356	Mg2+ binding site [ion binding]; other site
755178009357	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
755178009358	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
755178009359	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
755178009360	Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535
755178009361	active site
755178009362	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
755178009363	Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403
755178009364	Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454
755178009365	apolar tunnel; other site
755178009366	heme binding site [chemical binding]; other site
755178009367	dimerization interface [polypeptide binding]; other site
755178009368	Photosystem I reaction centre subunit XI; Region: PsaL; pfam02605
755178009369	photosystem I reaction center subunit VIII; Reviewed; Region: psaI; PRK11877
755178009370	Predicted O-methyltransferase [General function prediction only]; Region: COG4122
755178009371	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
755178009372	S-adenosylmethionine binding site [chemical binding]; other site
755178009373	MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300
755178009374	Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707
755178009375	Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707
755178009376	Domain of unknown function (DUF4388); Region: DUF4388; pfam14332
755178009377	Response regulator receiver domain; Region: Response_reg; pfam00072
755178009378	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
755178009379	active site
755178009380	phosphorylation site [posttranslational modification]
755178009381	intermolecular recognition site; other site
755178009382	dimerization interface [polypeptide binding]; other site
755178009383	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
755178009384	putative binding surface; other site
755178009385	active site
755178009386	Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643
755178009387	Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895
755178009388	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
755178009389	ATP binding site [chemical binding]; other site
755178009390	Mg2+ binding site [ion binding]; other site
755178009391	G-X-G motif; other site
755178009392	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256
755178009393	Response regulator receiver domain; Region: Response_reg; pfam00072
755178009394	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
755178009395	active site
755178009396	phosphorylation site [posttranslational modification]
755178009397	intermolecular recognition site; other site
755178009398	dimerization interface [polypeptide binding]; other site
755178009399	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
755178009400	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
755178009401	dimer interface [polypeptide binding]; other site
755178009402	putative CheW interface [polypeptide binding]; other site
755178009403	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cd00588
755178009404	Response regulator receiver domain; Region: Response_reg; pfam00072
755178009405	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
755178009406	active site
755178009407	phosphorylation site [posttranslational modification]
755178009408	intermolecular recognition site; other site
755178009409	dimerization interface [polypeptide binding]; other site
755178009410	Proline dehydrogenase; Region: Pro_dh; pfam01619
755178009411	Delta(1)-pyrroline-5-carboxylate dehydrogenase, RocA; Region: ALDH_PutA-P5CDH-RocA; cd07124
755178009412	delta-1-pyrroline-5-carboxylate dehydrogenase, group 2, putative; Region: D1pyr5carbox2; TIGR01237
755178009413	Glutamate binding site [chemical binding]; other site
755178009414	homodimer interface [polypeptide binding]; other site
755178009415	NAD binding site [chemical binding]; other site
755178009416	catalytic residues [active]
755178009417	tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815
755178009418	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
755178009419	FMN binding site [chemical binding]; other site
755178009420	active site
755178009421	catalytic residues [active]
755178009422	substrate binding site [chemical binding]; other site
755178009423	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
755178009424	Probable transposase; Region: OrfB_IS605; pfam01385
755178009425	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
755178009426	dsRNA-specific ribonuclease [Transcription]; Region: Rnc; COG0571
755178009427	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
755178009428	dimerization interface [polypeptide binding]; other site
755178009429	active site
755178009430	metal binding site [ion binding]; metal-binding site
755178009431	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
755178009432	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3224
755178009433	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
755178009434	nucleoside/Zn binding site; other site
755178009435	dimer interface [polypeptide binding]; other site
755178009436	catalytic motif [active]
755178009437	haemagglutination activity domain; Region: Haemagg_act; pfam05860
755178009438	CHAT domain; Region: CHAT; pfam12770
755178009439	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
755178009440	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
755178009441	substrate binding pocket [chemical binding]; other site
755178009442	Ion channel; Region: Ion_trans_2; pfam07885
755178009443	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
755178009444	membrane-bound complex binding site; other site
755178009445	hinge residues; other site
755178009446	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
755178009447	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
755178009448	Walker A/P-loop; other site
755178009449	ATP binding site [chemical binding]; other site
755178009450	Q-loop/lid; other site
755178009451	ABC transporter signature motif; other site
755178009452	Walker B; other site
755178009453	D-loop; other site
755178009454	H-loop/switch region; other site
755178009455	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
755178009456	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
755178009457	dimer interface [polypeptide binding]; other site
755178009458	conserved gate region; other site
755178009459	putative PBP binding loops; other site
755178009460	ABC-ATPase subunit interface; other site
755178009461	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
755178009462	ABC transporter periplasmic binding protein, urea carboxylase region; Region: ABC_peri_uca; TIGR03427
755178009463	hydrogenase accessory protein HypB; Region: hypB; TIGR00073
755178009464	Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375
755178009465	Hydrogenase expression/synthesis hypA family; Region: HypA; pfam01155
755178009466	agmatinase; Region: agmatinase; TIGR01230
755178009467	Agmatinase-like family; Region: Agmatinase-like; cd09990
755178009468	active site
755178009469	oligomer interface [polypeptide binding]; other site
755178009470	Mn binding site [ion binding]; other site
755178009471	CHAT domain; Region: CHAT; cl17868
755178009472	aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477
755178009473	GatB/GatE catalytic domain; Region: GatB_N; pfam02934
755178009474	GatB domain; Region: GatB_Yqey; smart00845
755178009475	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305
755178009476	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973
755178009477	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
755178009478	active site
755178009479	dimer interface [polypeptide binding]; other site
755178009480	motif 1; other site
755178009481	motif 2; other site
755178009482	motif 3; other site
755178009483	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
755178009484	anticodon binding site; other site
755178009485	Methyltransferase domain; Region: Methyltransf_26; pfam13659
755178009486	Transposase IS200 like; Region: Y1_Tnp; pfam01797
755178009487	Nitric oxide reductase large subunit [Inorganic ion transport and metabolism]; Region: NorB; COG3256
755178009488	Cupin domain; Region: Cupin_2; cl17218
755178009489	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Provisional; Region: PRK14619
755178009490	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
755178009491	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
755178009492	hydrolase, alpha/beta fold family protein; Region: PLN02824
755178009493	Serine hydrolase; Region: Ser_hydrolase; cl17834
755178009494	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
755178009495	metal binding site 2 [ion binding]; metal-binding site
755178009496	putative DNA binding helix; other site
755178009497	metal binding site 1 [ion binding]; metal-binding site
755178009498	dimer interface [polypeptide binding]; other site
755178009499	structural Zn2+ binding site [ion binding]; other site
755178009500	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
755178009501	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
755178009502	Walker A/P-loop; other site
755178009503	ATP binding site [chemical binding]; other site
755178009504	Q-loop/lid; other site
755178009505	ABC transporter signature motif; other site
755178009506	Walker B; other site
755178009507	D-loop; other site
755178009508	H-loop/switch region; other site
755178009509	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
755178009510	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
755178009511	active site
755178009512	phosphorylation site [posttranslational modification]
755178009513	intermolecular recognition site; other site
755178009514	dimerization interface [polypeptide binding]; other site
755178009515	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
755178009516	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
755178009517	dimer interface [polypeptide binding]; other site
755178009518	phosphorylation site [posttranslational modification]
755178009519	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
755178009520	ATP binding site [chemical binding]; other site
755178009521	Mg2+ binding site [ion binding]; other site
755178009522	G-X-G motif; other site
755178009523	Vitamin K epoxide reductase family in bacteria and plants; Region: VKOR_1; cd12916
755178009524	putative active site [active]
755178009525	substrate binding site [chemical binding]; other site
755178009526	redox center [active]
755178009527	membrane complex biogenesis protein, BtpA family; Region: thylakoid_BtpA; TIGR00259
755178009528	Domain of unknown function (DUF1902); Region: DUF1902; pfam08972
755178009529	YcfA-like protein; Region: YcfA; pfam07927
755178009530	Protein of unknown function (DUF4230); Region: DUF4230; pfam14014
755178009531	ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839
755178009532	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
755178009533	Walker A/P-loop; other site
755178009534	ATP binding site [chemical binding]; other site
755178009535	Q-loop/lid; other site
755178009536	ABC transporter signature motif; other site
755178009537	Walker B; other site
755178009538	D-loop; other site
755178009539	H-loop/switch region; other site
755178009540	Membrane protein of unknown function; Region: DUF360; pfam04020
755178009541	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
755178009542	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl17700
755178009543	Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cl17442
755178009544	protein-splicing catalytic site; other site
755178009545	thioester formation/cholesterol transfer; other site
755178009546	Intein/homing endonuclease [DNA replication, recombination, and repair]; Region: COG1372
755178009547	Hint (Hedgehog/Intein) domain C-terminal region; Region: HintC; smart00305
755178009548	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
755178009549	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
755178009550	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
755178009551	Conserved nitrate reductase-associated protein (Nitr_red_assoc); Region: Nitr_red_assoc; pfam09655
755178009552	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
755178009553	Malonyl-CoA synthetase (MCS); Region: MCS; cd05941
755178009554	acyl-activating enzyme (AAE) consensus motif; other site
755178009555	active site
755178009556	AMP binding site [chemical binding]; other site
755178009557	CoA binding site [chemical binding]; other site
755178009558	Domain of unknown function (DUF4131); Region: DUF4131; pfam13567
755178009559	Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658
755178009560	Competence protein; Region: Competence; pfam03772
755178009561	Photosystem II protein; Region: PSII; cl08223
755178009562	photosystem II 44 kDa subunit reaction center protein (also called P6 protein, CP43), bacterial and chloroplast; Region: psbC; TIGR01153
755178009563	Photosystem II, DII subunit (also called Q(A)); Region: psbD; TIGR01152
755178009564	pheophytin binding site; other site
755178009565	chlorophyll binding site; other site
755178009566	quinone binding site; other site
755178009567	Fe binding site [ion binding]; other site
755178009568	methionine sulfoxide reductase A; Provisional; Region: PRK14054
755178009569	methionine sulfoxide reductase B; Provisional; Region: PRK00222
755178009570	SelR domain; Region: SelR; pfam01641
755178009571	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
755178009572	Mechanosensitive ion channel; Region: MS_channel; pfam00924
755178009573	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
755178009574	Mechanosensitive ion channel; Region: MS_channel; pfam00924
755178009575	Sensory domain found in DIguanylate Cyclases & Two-component systems; Region: DICT; cl01731
755178009576	HD domain; Region: HD_5; pfam13487
755178009577	Predicted NAD/FAD-dependent oxidoreductase [General function prediction only]; Region: COG3380
755178009578	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
755178009579	pheophorbide a oxygenase; Region: PLN02518
755178009580	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
755178009581	iron-sulfur cluster [ion binding]; other site
755178009582	[2Fe-2S] cluster binding site [ion binding]; other site
755178009583	Pheophorbide a oxygenase; Region: PaO; pfam08417
755178009584	urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410
755178009585	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
755178009586	Walker A/P-loop; other site
755178009587	ATP binding site [chemical binding]; other site
755178009588	Q-loop/lid; other site
755178009589	ABC transporter signature motif; other site
755178009590	Walker B; other site
755178009591	D-loop; other site
755178009592	H-loop/switch region; other site
755178009593	urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411
755178009594	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
755178009595	Walker A/P-loop; other site
755178009596	ATP binding site [chemical binding]; other site
755178009597	Q-loop/lid; other site
755178009598	ABC transporter signature motif; other site
755178009599	Walker B; other site
755178009600	D-loop; other site
755178009601	H-loop/switch region; other site
755178009602	tellurium resistance terB-like protein; Region: terB_like; cd07177
755178009603	metal binding site [ion binding]; metal-binding site
755178009604	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
755178009605	Mechanosensitive ion channel; Region: MS_channel; pfam00924
755178009606	Domain of Unknown Function (DUF748); Region: DUF748; pfam05359
755178009607	Protein of unknown function; Region: DUF3971; pfam13116
755178009608	Family of unknown function (DUF490); Region: DUF490; pfam04357
755178009609	Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR6; cd08272
755178009610	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
755178009611	putative NAD(P) binding site [chemical binding]; other site
755178009612	UDP_sulfoquinovose_synthase (Arabidopsis thaliana SQD1 and related proteins), extended (e) SDRs; Region: SQD1_like_SDR_e; cd05255
755178009613	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
755178009614	NAD binding site [chemical binding]; other site
755178009615	substrate binding site [chemical binding]; other site
755178009616	active site
755178009617	Uncharacterized protein conserved in bacteria (DUF2063); Region: DUF2063; cl01262
755178009618	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
755178009619	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
755178009620	putative dimer interface [polypeptide binding]; other site
755178009621	Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243
755178009622	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754
755178009623	[4Fe-4S] binding site [ion binding]; other site
755178009624	molybdopterin cofactor binding site; other site
755178009625	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791
755178009626	molybdopterin cofactor binding site; other site
755178009627	Domain of unknown function (DUF3598); Region: DUF3598; pfam12204
755178009628	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
755178009629	S-adenosylmethionine binding site [chemical binding]; other site
755178009630	DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783
755178009631	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
755178009632	dimerization interface [polypeptide binding]; other site
755178009633	DPS ferroxidase diiron center [ion binding]; other site
755178009634	ion pore; other site
755178009635	type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843
755178009636	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
755178009637	HlyD family secretion protein; Region: HlyD_3; pfam13437
755178009638	ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995
755178009639	Ligand Binding Site [chemical binding]; other site
755178009640	putative fimbrial chaperone protein; Provisional; Region: PRK09918
755178009641	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
755178009642	Uncharacterized conserved protein [Function unknown]; Region: COG4279
755178009643	SWIM zinc finger; Region: SWIM; pfam04434
755178009644	S23 ribosomal protein; Region: Ribosomal_S23p; pfam05635
755178009645	four helix bundle protein; Region: TIGR02436
755178009646	Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003
755178009647	ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
755178009648	P loop; other site
755178009649	Nucleotide binding site [chemical binding]; other site
755178009650	Switch I; other site
755178009651	This domain family includes the alpha-crystallin domain (ACD) of alpha-crystallin-type small heat shock proteins (sHsps) and a similar domain found in p23-like proteins.  sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa; Region: ACD_sHsps_p23-like; cd00298
755178009652	Protein of unknown function (DUF2862); Region: DUF2862; pfam11061
755178009653	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
755178009654	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
755178009655	ABC-ATPase subunit  interface; other site
755178009656	dimer interface [polypeptide binding]; other site
755178009657	putative PBP binding regions; other site
755178009658	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
755178009659	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
755178009660	ABC-ATPase subunit  interface; other site
755178009661	dimer interface [polypeptide binding]; other site
755178009662	putative PBP binding regions; other site
755178009663	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
755178009664	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
755178009665	Walker A/P-loop; other site
755178009666	ATP binding site [chemical binding]; other site
755178009667	Q-loop/lid; other site
755178009668	ABC transporter signature motif; other site
755178009669	Walker B; other site
755178009670	D-loop; other site
755178009671	H-loop/switch region; other site
755178009672	Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_2; cd06160
755178009673	Peptidase family M50; Region: Peptidase_M50; pfam02163
755178009674	active site
755178009675	putative substrate binding region [chemical binding]; other site
755178009676	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
755178009677	dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088
755178009678	dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246
755178009679	NAD binding site [chemical binding]; other site
755178009680	substrate binding site [chemical binding]; other site
755178009681	homodimer interface [polypeptide binding]; other site
755178009682	active site
755178009683	prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052
755178009684	The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915
755178009685	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
755178009686	NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181
755178009687	active site
755178009688	Substrate binding site; other site
755178009689	Mg++ binding site; other site
755178009690	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
755178009691	putative trimer interface [polypeptide binding]; other site
755178009692	putative CoA binding site [chemical binding]; other site
755178009693	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
755178009694	homodimer interface [polypeptide binding]; other site
755178009695	substrate-cofactor binding pocket; other site
755178009696	Aminotransferase class IV; Region: Aminotran_4; pfam01063
755178009697	pyridoxal 5'-phosphate binding site [chemical binding]; other site
755178009698	catalytic residue [active]
755178009699	PsaD; Region: PsaD; pfam02531
755178009700	cobyric acid synthase; Provisional; Region: PRK00784
755178009701	dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090
755178009702	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750
755178009703	catalytic triad [active]
755178009704	Protein of unknown function (DUF2993); Region: DUF2993; pfam11209
755178009705	TRX-like protein A (TxlA) family; TxlA was originally isolated from the cyanobacterium Synechococcus. It is found only in oxygenic photosynthetic organisms. TRX is a small enzyme that participate in redox reactions, via the reversible oxidation of an...; Region: TxlA; cd02950
755178009706	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
755178009707	catalytic residues [active]
755178009708	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
755178009709	Peptidase family M23; Region: Peptidase_M23; pfam01551
755178009710	Domain of unknown function (DUF1817); Region: DUF1817; pfam08847
755178009711	Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419
755178009712	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
755178009713	motif II; other site
755178009714	Acylphosphatase; Region: Acylphosphatase; pfam00708
755178009715	Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068
755178009716	HypF finger; Region: zf-HYPF; pfam07503
755178009717	HypF finger; Region: zf-HYPF; pfam07503
755178009718	Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300
755178009719	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
755178009720	Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375
755178009721	Hydrogenase expression/synthesis hypA family; Region: HypA; pfam01155
755178009722	Gas vesicle protein [General function prediction only]; Region: GvpP; COG4980
755178009723	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
755178009724	active site
755178009725	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220
755178009726	chlorophyll a/b binding light-harvesting protein; Region: PS_antenn_a_b; TIGR03041
755178009727	flavodoxin FldA; Validated; Region: PRK09267
755178009728	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
755178009729	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
755178009730	Predicted membrane protein [Function unknown]; Region: COG2246
755178009731	GtrA-like protein; Region: GtrA; pfam04138
755178009732	circadian clock protein KaiC; Reviewed; Region: PRK09302
755178009733	KaiC is a circadian clock protein primarily found in cyanobacteria KaiC is a RecA-like ATPase, having both Walker A and Walker B motifs. A related protein is found in archaea; Region: KaiC; cd01124
755178009734	Walker A motif; other site
755178009735	ATP binding site [chemical binding]; other site
755178009736	Walker B motif; other site
755178009737	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
755178009738	ATP binding site [chemical binding]; other site
755178009739	Walker B motif; other site
755178009740	KaiB-like family; composed of the circadian clock proteins, KaiB and the N-terminal KaiB-like sensory domain of SasA. KaiB is an essential protein in maintaining circadian rhythm. It was originally discovered from the cyanobacterium Synechococcus as part...; Region: KaiB_like; cd02978
755178009741	tetramer interface [polypeptide binding]; other site
755178009742	dimer interface [polypeptide binding]; other site
755178009743	KaiA domain; Region: KaiA; pfam07688
755178009744	hypothetical protein; Validated; Region: PRK00110
755178009745	Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339
755178009746	Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456
755178009747	active site
755178009748	Zn binding site [ion binding]; other site
755178009749	Uncharacterized protein family (UPF0150); Region: UPF0150; cl00691
755178009750	YcfA-like protein; Region: YcfA; pfam07927
755178009751	Protein of unknown function (DUF433); Region: DUF433; pfam04255
755178009752	flavoprotein, HI0933 family; Region: TIGR00275
755178009753	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
755178009754	ATP synthase CF1 epsilon subunit; Region: atpE; CHL00063
755178009755	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
755178009756	gamma subunit interface [polypeptide binding]; other site
755178009757	epsilon subunit interface [polypeptide binding]; other site
755178009758	LBP interface [polypeptide binding]; other site
755178009759	ATP synthase CF1 beta subunit; Region: atpB; CHL00060
755178009760	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
755178009761	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
755178009762	alpha subunit interaction interface [polypeptide binding]; other site
755178009763	Walker A motif; other site
755178009764	ATP binding site [chemical binding]; other site
755178009765	Walker B motif; other site
755178009766	inhibitor binding site; inhibition site
755178009767	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
755178009768	tellurium resistance terB-like protein; Region: terB_like; cd07177
755178009769	metal binding site [ion binding]; metal-binding site
755178009770	16S rRNA methyltransferase B; Provisional; Region: PRK14901
755178009771	NusB family; Region: NusB; pfam01029
755178009772	putative RNA binding site [nucleotide binding]; other site
755178009773	FtsJ-like methyltransferase; Region: FtsJ; cl17430
755178009774	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
755178009775	S-adenosylmethionine binding site [chemical binding]; other site
755178009776	NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649
755178009777	NAD(P)H-quinone oxidoreductase subunit H; Validated; Region: PRK07415
755178009778	multidrug efflux protein; Reviewed; Region: PRK01766
755178009779	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131
755178009780	cation binding site [ion binding]; other site
755178009781	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
755178009782	CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492
755178009783	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683
755178009784	GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate.  The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria.  In...; Region: GTP_cyclohydro1; cd00642
755178009785	homodecamer interface [polypeptide binding]; other site
755178009786	GTP cyclohydrolase I; Provisional; Region: PLN03044
755178009787	active site
755178009788	putative catalytic site residues [active]
755178009789	zinc binding site [ion binding]; other site
755178009790	GTP-CH-I/GFRP interaction surface; other site
755178009791	PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861
755178009792	putative active site [active]
755178009793	Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823
755178009794	dimer interface [polypeptide binding]; other site
755178009795	active site
755178009796	aspartate-rich active site metal binding site; other site
755178009797	allosteric magnesium binding site [ion binding]; other site
755178009798	Schiff base residues; other site
755178009799	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
755178009800	metal binding site 2 [ion binding]; metal-binding site
755178009801	putative DNA binding helix; other site
755178009802	metal binding site 1 [ion binding]; metal-binding site
755178009803	dimer interface [polypeptide binding]; other site
755178009804	structural Zn2+ binding site [ion binding]; other site
755178009805	Predicted membrane protein (DUF2207); Region: DUF2207; pfam09972
755178009806	Rubrerythrin [Energy production and conversion]; Region: COG1592
755178009807	ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346
755178009808	Clp amino terminal domain; Region: Clp_N; pfam02861
755178009809	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
755178009810	Walker A motif; other site
755178009811	ATP binding site [chemical binding]; other site
755178009812	Walker B motif; other site
755178009813	arginine finger; other site
755178009814	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
755178009815	Walker A motif; other site
755178009816	ATP binding site [chemical binding]; other site
755178009817	Walker B motif; other site
755178009818	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
755178009819	Protein of unknown function (DUF1622); Region: DUF1622; pfam07784
755178009820	Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768
755178009821	Septum formation topological specificity factor MinE; Region: MinE; cl00538
755178009822	Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894
755178009823	Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036
755178009824	P-loop; other site
755178009825	ADP binding residues [chemical binding]; other site
755178009826	Switch I; other site
755178009827	Switch II; other site
755178009828	Major Facilitator Superfamily; Region: MFS_1; pfam07690
755178009829	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
755178009830	putative substrate translocation pore; other site
755178009831	Protein of unknown function (DUF938); Region: DUF938; pfam06080
755178009832	Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508
755178009833	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883
755178009834	nudix motif; other site
755178009835	Choloylglycine hydrolase (CGH) is a bile salt-modifying enzyme that hydrolyzes non-peptide carbon-nitrogen bonds in choloylglycine and choloyltaurine, both of which are present in bile.  CGH is present in a number of probiotic microbial organisms that...; Region: Ntn_CGH; cd01902
755178009836	Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275
755178009837	Domain of unknown function (DUF1815); Region: DUF1815; pfam08844
755178009838	NAD(P)H-quinone oxidoreductase subunit 4; Provisional; Region: PRK12561
755178009839	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
755178009840	bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805
755178009841	Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122
755178009842	putative catalytic cysteine [active]
755178009843	C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178
755178009844	putative active site [active]
755178009845	metal binding site [ion binding]; metal-binding site
755178009846	S23 ribosomal protein; Region: Ribosomal_S23p; pfam05635
755178009847	four helix bundle protein; Region: TIGR02436
755178009848	4Fe-4S single cluster domain; Region: Fer4_13; pfam13370
755178009849	Ycf35; Provisional; Region: ycf35; CHL00193
755178009850	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
755178009851	putative active site [active]
755178009852	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
755178009853	active site
755178009854	NTP binding site [chemical binding]; other site
755178009855	metal binding triad [ion binding]; metal-binding site
755178009856	antibiotic binding site [chemical binding]; other site
755178009857	Uncharacterized conserved protein [Function unknown]; Region: COG2361
755178009858	Protein of unknown function (DUF2997); Region: DUF2997; pfam11211
755178009859	methylthioribulose-1-phosphate dehydratase; Provisional; Region: PRK09220
755178009860	intersubunit interface [polypeptide binding]; other site
755178009861	active site
755178009862	Zn2+ binding site [ion binding]; other site
755178009863	ARD/ARD' family; Region: ARD; pfam03079
755178009864	Cupin domain; Region: Cupin_2; pfam07883
755178009865	6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242
755178009866	active site
755178009867	Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514
755178009868	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
755178009869	ATP binding site [chemical binding]; other site
755178009870	putative Mg++ binding site [ion binding]; other site
755178009871	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
755178009872	nucleotide binding region [chemical binding]; other site
755178009873	ATP-binding site [chemical binding]; other site
755178009874	This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956
755178009875	HRDC domain; Region: HRDC; pfam00570
755178009876	Uncharacterized conserved protein [Function unknown]; Region: COG0393
755178009877	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
755178009878	active site
755178009879	I-site; other site
755178009880	metal binding site [ion binding]; metal-binding site
755178009881	Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG0429
755178009882	Uncharacterized conserved protein [Function unknown]; Region: COG0432
755178009883	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
755178009884	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
755178009885	Coenzyme A binding pocket [chemical binding]; other site
755178009886	Rhomboid family; Region: Rhomboid; pfam01694
755178009887	Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561
755178009888	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
755178009889	active site
755178009890	motif I; other site
755178009891	motif II; other site
755178009892	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
755178009893	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
755178009894	nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562
755178009895	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528
755178009896	homodimer interface [polypeptide binding]; other site
755178009897	metal binding site [ion binding]; metal-binding site
755178009898	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529
755178009899	homodimer interface [polypeptide binding]; other site
755178009900	active site
755178009901	putative chemical substrate binding site [chemical binding]; other site
755178009902	metal binding site [ion binding]; metal-binding site
755178009903	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
755178009904	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967
755178009905	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
755178009906	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
755178009907	CESA_like is  the cellulose synthase superfamily; Region: CESA_like; cd06423
755178009908	DXD motif; other site
755178009909	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_8; cd07817
755178009910	putative hydrophobic ligand binding site [chemical binding]; other site
755178009911	RNA polymerase sigma factor RpoD; Validated; Region: PRK07406
755178009912	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
755178009913	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
755178009914	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
755178009915	DNA binding residues [nucleotide binding]
755178009916	Bacterioferritin-associated ferredoxin [Inorganic ion transport and metabolism]; Region: Bfd; COG2906
755178009917	Uncharacterized protein family (UPF0227); Region: UPF0227; cl14886
755178009918	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
755178009919	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4398
755178009920	FIST N domain; Region: FIST; pfam08495
755178009921	FIST C domain; Region: FIST_C; pfam10442
755178009922	rod shape-determining protein MreB; Provisional; Region: PRK13927
755178009923	MreB and similar proteins; Region: MreB_like; cd10225
755178009924	nucleotide binding site [chemical binding]; other site
755178009925	Mg binding site [ion binding]; other site
755178009926	putative protofilament interaction site [polypeptide binding]; other site
755178009927	RodZ interaction site [polypeptide binding]; other site
755178009928	NAD(P)H-quinone oxidoreductase subunit 2; Provisional; Region: PRK02504
755178009929	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
755178009930	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
755178009931	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
755178009932	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
755178009933	RecB family nuclease, putative, TM0106 family; Region: TIGR03491
755178009934	RNase_H superfamily; Region: RNase_H_2; pfam13482
755178009935	S-adenosylmethionine synthetase; Validated; Region: PRK05250
755178009936	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
755178009937	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
755178009938	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
755178009939	Protein of unknown function (DUF1176); Region: DUF1176; pfam06674
755178009940	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
755178009941	Protein of unknown function (DUF1822); Region: DUF1822; pfam08852
755178009942	Protein of unknown function (DUF1822); Region: DUF1822; pfam08852
755178009943	Uncharacterized ACR, COG1430; Region: DUF192; pfam02643
755178009944	Protein of unknown function (DUF2949); Region: DUF2949; pfam11165
755178009945	branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856
755178009946	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
755178009947	E3 interaction surface; other site
755178009948	lipoyl attachment site [posttranslational modification]; other site
755178009949	e3 binding domain; Region: E3_binding; pfam02817
755178009950	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
755178009951	geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032
755178009952	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
755178009953	Survival protein SurE; Region: SurE; cl00448
755178009954	Sodium:dicarboxylate symporter family; Region: SDF; cl00573
755178009955	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
755178009956	Sodium:dicarboxylate symporter family; Region: SDF; pfam00375
755178009957	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
755178009958	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
755178009959	Cysteine-rich domain; Region: CCG; pfam02754
755178009960	Cysteine-rich domain; Region: CCG; pfam02754
755178009961	aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034
755178009962	photosystem I assembly protein Ycf3; Provisional; Region: PRK02603
755178009963	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
755178009964	binding surface
755178009965	TPR motif; other site
755178009966	Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371
755178009967	Glycerol dehydrogenases-like; Region: GlyDH-like1; cd08172
755178009968	putative active site [active]
755178009969	metal binding site [ion binding]; metal-binding site
755178009970	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4239
755178009971	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
755178009972	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
755178009973	dimer interface [polypeptide binding]; other site
755178009974	conserved gate region; other site
755178009975	putative PBP binding loops; other site
755178009976	ABC-ATPase subunit interface; other site
755178009977	S23 ribosomal protein; Region: Ribosomal_S23p; pfam05635
755178009978	four helix bundle protein; Region: TIGR02436
755178009979	DNA phosphorothioation system restriction enzyme; Region: dnd_restrict_1; TIGR04095
755178009980	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
755178009981	ATP binding site [chemical binding]; other site
755178009982	putative Mg++ binding site [ion binding]; other site
755178009983	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
755178009984	nucleotide binding region [chemical binding]; other site
755178009985	ATP-binding site [chemical binding]; other site
755178009986	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892
755178009987	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613
755178009988	UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352
755178009989	trimer interface [polypeptide binding]; other site
755178009990	active site
755178009991	UDP-GlcNAc binding site [chemical binding]; other site
755178009992	lipid binding site [chemical binding]; lipid-binding site
755178009993	Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310
755178009994	Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974
755178009995	putative metal binding site [ion binding]; other site
755178009996	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
755178009997	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
755178009998	Protein of unknown function (DUF4007); Region: DUF4007; pfam13182
755178009999	Uncharacterized protein conserved in bacteria (DUF2191); Region: DUF2191; pfam09957
755178010000	PIN domain; Region: PIN_3; cl17397
755178010001	HNH endonuclease; Region: HNH_4; pfam13395
755178010002	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
755178010003	DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674
755178010004	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
755178010005	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
755178010006	PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882
755178010007	putative active site [active]
755178010008	Uncharacterized protein conserved in bacteria (DUF2191); Region: DUF2191; pfam09957
755178010009	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
755178010010	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
755178010011	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
755178010012	catalytic residue [active]
755178010013	3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427
755178010014	EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556
755178010015	hinge; other site
755178010016	active site
755178010017	ribosome recycling factor; Reviewed; Region: frr; PRK00083
755178010018	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520
755178010019	hinge region; other site
755178010020	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
755178010021	putative nucleotide binding site [chemical binding]; other site
755178010022	uridine monophosphate binding site [chemical binding]; other site
755178010023	homohexameric interface [polypeptide binding]; other site
755178010024	dihydrodipicolinate reductase; Provisional; Region: PRK00048
755178010025	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
755178010026	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
755178010027	glycogen synthase; Provisional; Region: glgA; PRK00654
755178010028	This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791
755178010029	ADP-binding pocket [chemical binding]; other site
755178010030	homodimer interface [polypeptide binding]; other site
755178010031	Domain of unknown function (DUF4335); Region: DUF4335; pfam14233
755178010032	Sec-independent translocase component C; Provisional; Region: tatC; CHL00182
755178010033	Late competence development protein ComFB; Region: ComFB; pfam10719
755178010034	prolyl-tRNA synthetase; Provisional; Region: PRK09194
755178010035	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779
755178010036	dimer interface [polypeptide binding]; other site
755178010037	motif 1; other site
755178010038	active site
755178010039	motif 2; other site
755178010040	INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334
755178010041	putative deacylase active site [active]
755178010042	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
755178010043	active site
755178010044	motif 3; other site
755178010045	ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861
755178010046	anticodon binding site; other site
755178010047	Uncharacterized metal-binding protein (DUF2227); Region: DUF2227; pfam09988
755178010048	Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370
755178010049	Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879
755178010050	G1 box; other site
755178010051	GTP/Mg2+ binding site [chemical binding]; other site
755178010052	Switch I region; other site
755178010053	G2 box; other site
755178010054	G3 box; other site
755178010055	Switch II region; other site
755178010056	G4 box; other site
755178010057	G5 box; other site
755178010058	Nucleoside recognition; Region: Gate; pfam07670
755178010059	Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664
755178010060	Nucleoside recognition; Region: Gate; pfam07670
755178010061	Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022
755178010062	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
755178010063	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
755178010064	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
755178010065	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
755178010066	The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432
755178010067	dimerization interface [polypeptide binding]; other site
755178010068	substrate binding pocket [chemical binding]; other site
755178010069	Cupin domain; Region: Cupin_2; cl17218
755178010070	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
755178010071	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
755178010072	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
755178010073	Probable transposase; Region: OrfB_IS605; pfam01385
755178010074	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
755178010075	ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14457
755178010076	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
755178010077	FeS/SAM binding site; other site
755178010078	chaperone protein DnaJ; Provisional; Region: PRK14299
755178010079	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
755178010080	HSP70 interaction site [polypeptide binding]; other site
755178010081	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
755178010082	substrate binding site [polypeptide binding]; other site
755178010083	dimer interface [polypeptide binding]; other site
755178010084	Uncharacterized conserved protein [Function unknown]; Region: COG4095
755178010085	single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644
755178010086	DHH family; Region: DHH; pfam01368
755178010087	Domain of unknown function DUF39; Region: DUF39; pfam01837
755178010088	Response regulator receiver domain; Region: Response_reg; pfam00072
755178010089	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
755178010090	active site
755178010091	phosphorylation site [posttranslational modification]
755178010092	intermolecular recognition site; other site
755178010093	dimerization interface [polypeptide binding]; other site
755178010094	Response regulator receiver domain; Region: Response_reg; pfam00072
755178010095	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
755178010096	active site
755178010097	phosphorylation site [posttranslational modification]
755178010098	intermolecular recognition site; other site
755178010099	dimerization interface [polypeptide binding]; other site
755178010100	Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly.  The complex contains two alpha and four beta subunits, the two subunits...; Region: Prefoldin; cl09111
755178010101	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
755178010102	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
755178010103	metal binding site [ion binding]; metal-binding site
755178010104	active site
755178010105	I-site; other site
755178010106	Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893
755178010107	active site
755178010108	catalytic site [active]
755178010109	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
755178010110	Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282
755178010111	HupF/HypC family; Region: HupF_HypC; pfam01455
755178010112	S23 ribosomal protein; Region: Ribosomal_S23p; pfam05635
755178010113	four helix bundle protein; Region: TIGR02436
755178010114	bidirectional hydrogenase complex protein HoxE; Reviewed; Region: PRK07571
755178010115	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064
755178010116	putative dimer interface [polypeptide binding]; other site
755178010117	[2Fe-2S] cluster binding site [ion binding]; other site
755178010118	Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980
755178010119	dimer interface [polypeptide binding]; other site
755178010120	[2Fe-2S] cluster binding site [ion binding]; other site
755178010121	NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894
755178010122	SLBB domain; Region: SLBB; pfam10531
755178010123	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589
755178010124	bidirectional hydrogenase complex protein HoxU; Validated; Region: PRK07569
755178010125	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
755178010126	catalytic loop [active]
755178010127	iron binding site [ion binding]; other site
755178010128	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588
755178010129	4Fe-4S binding domain; Region: Fer4; cl02805
755178010130	Coenzyme F420-reducing hydrogenase, gamma subunit [Energy production and conversion]; Region: FrhG; COG1941
755178010131	NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058
755178010132	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
755178010133	putative active site [active]
755178010134	Predicted helicase [General function prediction only]; Region: COG4889
755178010135	Coenzyme F420-reducing hydrogenase, alpha subunit [Energy production and conversion]; Region: FrhA; COG3259
755178010136	Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374
755178010137	Response regulator receiver domain; Region: Response_reg; pfam00072
755178010138	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
755178010139	active site
755178010140	phosphorylation site [posttranslational modification]
755178010141	intermolecular recognition site; other site
755178010142	dimerization interface [polypeptide binding]; other site
755178010143	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
755178010144	dimer interface [polypeptide binding]; other site
755178010145	phosphorylation site [posttranslational modification]
755178010146	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
755178010147	ATP binding site [chemical binding]; other site
755178010148	Mg2+ binding site [ion binding]; other site
755178010149	G-X-G motif; other site
755178010150	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205
755178010151	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
755178010152	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
755178010153	putative active site [active]
755178010154	heme pocket [chemical binding]; other site
755178010155	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
755178010156	putative active site [active]
755178010157	heme pocket [chemical binding]; other site
755178010158	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
755178010159	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
755178010160	putative active site [active]
755178010161	heme pocket [chemical binding]; other site
755178010162	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
755178010163	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
755178010164	putative active site [active]
755178010165	heme pocket [chemical binding]; other site
755178010166	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
755178010167	heme pocket [chemical binding]; other site
755178010168	putative active site [active]
755178010169	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
755178010170	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
755178010171	dimer interface [polypeptide binding]; other site
755178010172	phosphorylation site [posttranslational modification]
755178010173	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
755178010174	ATP binding site [chemical binding]; other site
755178010175	Mg2+ binding site [ion binding]; other site
755178010176	G-X-G motif; other site
755178010177	Response regulator receiver domain; Region: Response_reg; pfam00072
755178010178	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
755178010179	active site
755178010180	phosphorylation site [posttranslational modification]
755178010181	intermolecular recognition site; other site
755178010182	dimerization interface [polypeptide binding]; other site
755178010183	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
755178010184	lipoyl attachment site [posttranslational modification]; other site
755178010185	Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618
755178010186	DHH family; Region: DHH; pfam01368
755178010187	FOG: CBS domain [General function prediction only]; Region: COG0517
755178010188	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with an upstream DHH domain which performs a phosphoesterase function and a downstream polyA polymerase domain. CBS is a small domain originally...; Region: CBS_pair_DHH_polyA_Pol_assoc; cd04595
755178010189	tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617
755178010190	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
755178010191	active site
755178010192	NTP binding site [chemical binding]; other site
755178010193	metal binding triad [ion binding]; metal-binding site
755178010194	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
755178010195	tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735
755178010196	Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974
755178010197	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
755178010198	DNA binding site [nucleotide binding]
755178010199	Int/Topo IB signature motif; other site
755178010200	active site
755178010201	catalytic residues [active]
755178010202	Mth938-like domain. The members of this family include: Mth938, 2P1, Xcr35, Rpa2829, and several uncharacterized sequences. Mth938 is a hypothetical protein encoded by the Methanobacterium thermoautotrophicum (Mth) genome. This protein crystallizes as a...; Region: Mth938-like; cl00182
755178010203	TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029
755178010204	active site
755178010205	metal binding site [ion binding]; metal-binding site
755178010206	interdomain interaction site; other site
755178010207	Protein of unknown function (DUF3987); Region: DUF3987; pfam13148
755178010208	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
755178010209	UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580
755178010210	Family description; Region: UvrD_C_2; pfam13538
755178010211	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
755178010212	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
755178010213	P-loop; other site
755178010214	Magnesium ion binding site [ion binding]; other site
755178010215	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
755178010216	Magnesium ion binding site [ion binding]; other site
755178010217	ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180
755178010218	ParB-like nuclease domain; Region: ParBc; pfam02195
755178010219	Protein of unknown function (DUF1052); Region: DUF1052; cl02197
755178010220	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
755178010221	active site
755178010222	catalytic site [active]
755178010223	substrate binding site [chemical binding]; other site
755178010224	Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040
755178010225	catalytic core [active]
755178010226	Abi-like protein; Region: Abi_2; pfam07751
755178010227	DDE superfamily endonuclease; Region: DDE_3; pfam13358
755178010228	Homeodomain-like domain; Region: HTH_23; pfam13384
755178010229	Winged helix-turn helix; Region: HTH_29; pfam13551
755178010230	Winged helix-turn helix; Region: HTH_33; pfam13592
755178010231	AAA domain; Region: AAA_33; pfam13671
755178010232	AAA domain; Region: AAA_17; pfam13207
755178010233	WYL domain; Region: WYL; pfam13280
755178010234	CRISPR-associated protein; Region: DUF3692; pfam12469
755178010235	CRISPR/Cas system-associated protein Cas10; Region: Cas10_III; cl13853
755178010236	CRISPR-associated protein (Cas_Cmr3); Region: Cas_Cmr3; pfam09700
755178010237	CRISPR/Cas system-associated RAMP superfamily protein Cmr3; Region: Cmr3_III-B; cl12075
755178010238	CRISPR/Cas system-associated RAMP superfamily protein Cmr4; Region: Cmr4_III-B; cl17440
755178010239	Phage derived protein Gp49-like (DUF891); Region: Gp49; pfam05973
755178010240	CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cl17214
755178010241	CRISPR/Cas system-associated protein Csm6; Region: Csm6_III-A; cl09873
755178010242	WYL domain; Region: WYL; pfam13280
755178010243	CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cd09634
755178010244	CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725
755178010245	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
755178010246	haloacid dehalogenase superfamily, subfamily IA, variant 1 with third motif having Dx(3-4)D or Dx(3-4)E; Region: HAD-SF-IA-v1; TIGR01549
755178010247	active site
755178010248	motif I; other site
755178010249	motif II; other site
755178010250	Protein of unknown function (DUF2808); Region: DUF2808; pfam10989
755178010251	Methyltransferase domain; Region: Methyltransf_23; pfam13489
755178010252	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
755178010253	S-adenosylmethionine binding site [chemical binding]; other site
755178010254	Homeodomain-like domain; Region: HTH_23; pfam13384
755178010255	Winged helix-turn helix; Region: HTH_29; pfam13551
755178010256	Winged helix-turn helix; Region: HTH_33; pfam13592
755178010257	DDE superfamily endonuclease; Region: DDE_3; pfam13358
755178010258	Caspase domain; Region: Peptidase_C14; pfam00656
755178010259	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
755178010260	Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737
755178010261	catalytic residues [active]
755178010262	Protein of unknown function (DUF1273); Region: DUF1273; cl01859
755178010263	Invasion plasmid antigen IpaD; Region: IpaD; cl05827
755178010264	Domain of unknown function (DUF4326); Region: DUF4326; pfam14216
755178010265	Staphylococcal nuclease homologues; Region: SNc; smart00318
755178010266	Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140
755178010267	Catalytic site; other site