-- dump date 20140619_054042 -- class Genbank::misc_feature -- table misc_feature_note -- id note 266264000001 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 266264000002 DNA binding residues [nucleotide binding] 266264000003 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 266264000004 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 266264000005 P-loop; other site 266264000006 Magnesium ion binding site [ion binding]; other site 266264000007 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 266264000008 Magnesium ion binding site [ion binding]; other site 266264000009 ParB-like nuclease domain; Region: ParBc; pfam02195 266264000010 Initiator Replication protein; Region: Rep_3; pfam01051 266264000011 PAS domain; Region: PAS_9; pfam13426 266264000012 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 266264000013 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 266264000014 active site 266264000015 I-site; other site 266264000016 metal binding site [ion binding]; metal-binding site 266264000017 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 266264000018 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14954 266264000019 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 266264000020 Family description; Region: UvrD_C_2; pfam13538 266264000021 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 266264000022 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843 266264000023 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 266264000024 Protein of unknwon function (DUF2893); Region: DUF2893; pfam11459 266264000025 Uncharacterized protein conserved in bacteria (DUF2191); Region: DUF2191; pfam09957 266264000026 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 266264000027 putative active site [active] 266264000028 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 266264000029 Active Sites [active] 266264000030 HNH endonuclease; Region: HNH_2; pfam13391 266264000031 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 266264000032 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 266264000033 DNA binding site [nucleotide binding] 266264000034 chaperone protein DnaJ; Provisional; Region: PRK14282 266264000035 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 266264000036 HSP70 interaction site [polypeptide binding]; other site 266264000037 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 266264000038 Zn binding sites [ion binding]; other site 266264000039 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 266264000040 dimer interface [polypeptide binding]; other site 266264000041 Protein of unknown function (DUF3620); Region: DUF3620; pfam12281 266264000042 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 266264000043 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 266264000044 trimer interface [polypeptide binding]; other site 266264000045 eyelet of channel; other site 266264000046 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 266264000047 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 266264000048 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 266264000049 Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299 266264000050 active site 266264000051 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 266264000052 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 266264000053 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 266264000054 Transcriptional regulators [Transcription]; Region: FadR; COG2186 266264000055 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266264000056 DNA-binding site [nucleotide binding]; DNA binding site 266264000057 FCD domain; Region: FCD; pfam07729 266264000058 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 266264000059 MerT mercuric transport protein; Region: MerT; cl03578 266264000060 Helix-Turn-Helix DNA binding domain of the MerR1 transcription regulator; Region: HTH_MerR1; cd04783 266264000061 Hg(II)-responsive transcriptional regulator; Region: MerR; TIGR02051 266264000062 DNA binding residues [nucleotide binding] 266264000063 dimer interface [polypeptide binding]; other site 266264000064 mercury binding site [ion binding]; other site 266264000065 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 266264000066 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 266264000067 Cytochrome c; Region: Cytochrom_C; pfam00034 266264000068 Cytochrome c [Energy production and conversion]; Region: COG3258 266264000069 Cytochrome c; Region: Cytochrom_C; pfam00034 266264000070 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 266264000071 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235 266264000072 INT_SG1, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 1, C-terminal catalytic domain. The CD contains mainly predicted integrase/recombinase and site-specific XerD recombinases. The members of this CD are found predominantly in...; Region: INT_SG1_C; cd01183 266264000073 Int/Topo IB signature motif; other site 266264000074 transcriptional regulator, AraC family (fragment) 266264000075 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 266264000076 MgtC family; Region: MgtC; pfam02308 266264000077 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 266264000078 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 266264000079 Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999 266264000080 HlyD family secretion protein; Region: HlyD_3; pfam13437 266264000081 heavy metal efflux pump, CzcA family; Region: 2A0601; TIGR00914 266264000082 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 266264000083 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 266264000084 heavy metal response regulator; Region: cztR_silR_copR; TIGR01387 266264000085 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266264000086 active site 266264000087 phosphorylation site [posttranslational modification] 266264000088 intermolecular recognition site; other site 266264000089 dimerization interface [polypeptide binding]; other site 266264000090 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 266264000091 DNA binding site [nucleotide binding] 266264000092 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 266264000093 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 266264000094 dimerization interface [polypeptide binding]; other site 266264000095 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 266264000096 dimer interface [polypeptide binding]; other site 266264000097 phosphorylation site [posttranslational modification] 266264000098 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266264000099 ATP binding site [chemical binding]; other site 266264000100 Mg2+ binding site [ion binding]; other site 266264000101 G-X-G motif; other site 266264000102 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 266264000103 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 266264000104 trimer interface [polypeptide binding]; other site 266264000105 eyelet of channel; other site 266264000106 putative transposase OrfB; Reviewed; Region: PHA02517 266264000107 HTH-like domain; Region: HTH_21; pfam13276 266264000108 Integrase core domain; Region: rve; pfam00665 266264000109 Integrase core domain; Region: rve_3; pfam13683 266264000110 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 266264000111 Transposase; Region: HTH_Tnp_1; cl17663 266264000112 flagellar basal-body rod protein FlgB; Region: FlgB; TIGR01396 266264000113 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182 266264000114 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 266264000115 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 266264000116 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 266264000117 Soluble P-type ATPase [General function prediction only]; Region: COG4087 266264000118 zinc-ribbon domain; Region: zf-ribbon_3; cl11198 266264000119 Double zinc ribbon; Region: DZR; pfam12773 266264000120 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 266264000121 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 266264000122 Ligand binding site; other site 266264000123 Putative Catalytic site; other site 266264000124 DXD motif; other site 266264000125 GtrA-like protein; Region: GtrA; pfam04138 266264000126 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 266264000127 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 266264000128 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 266264000129 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 266264000130 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 266264000131 Transposase; Region: HTH_Tnp_1; pfam01527 266264000132 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 266264000133 Helix-turn-helix domain; Region: HTH_38; pfam13936 266264000134 Integrase core domain; Region: rve; pfam00665 266264000135 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 266264000136 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 266264000137 active site 266264000138 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 266264000139 lipoprotein signal peptidase; Provisional; Region: PRK14787 266264000140 Heavy-metal-associated domain; Region: HMA; pfam00403 266264000141 metal-binding site [ion binding] 266264000142 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 266264000143 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 266264000144 metal-binding site [ion binding] 266264000145 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 266264000146 Soluble P-type ATPase [General function prediction only]; Region: COG4087 266264000147 Cd(II)/Pb(II)-responsive transcriptional regulator; Region: CadR-PbrR; TIGR02047 266264000148 Helix-Turn-Helix DNA binding domain of the CadR and PbrR transcription regulators; Region: HTH_CadR-PbrR; cd04784 266264000149 DNA binding residues [nucleotide binding] 266264000150 dimer interface [polypeptide binding]; other site 266264000151 putative metal binding site [ion binding]; other site 266264000152 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 266264000153 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 266264000154 High-affinity Fe2+/Pb2+ permease [Inorganic ion transport and metabolism]; Region: FTR1; COG0672 266264000155 AAA domain; Region: AAA_22; pfam13401 266264000156 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 266264000157 Walker A motif; other site 266264000158 ATP binding site [chemical binding]; other site 266264000159 Walker B motif; other site 266264000160 arginine finger; other site 266264000161 Integrase core domain; Region: rve; pfam00665 266264000162 Domain of unknown function (DUF4158); Region: DUF4158; pfam13700 266264000163 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; pfam01526 266264000164 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 266264000165 Domain of unknown function (DUF3330); Region: DUF3330; pfam11809 266264000166 putative mercury resistance protein; Provisional; Region: PRK13747 266264000167 transcriptional regulator MerD; Provisional; Region: PRK13749 266264000168 Helix-Turn-Helix DNA binding domain of the MerD transcription regulator; Region: HTH_MerD; cd01111 266264000169 DNA binding residues [nucleotide binding] 266264000170 putative dimer interface [polypeptide binding]; other site 266264000171 putative mercuric reductase; Provisional; Region: PRK13748 266264000172 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 266264000173 metal-binding site [ion binding] 266264000174 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 266264000175 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 266264000176 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 266264000177 metal-binding site [ion binding] 266264000178 putative mercuric transport protein; Provisional; Region: PRK13751 266264000179 putative transcriptional regulator MerR; Provisional; Region: PRK13752 266264000180 Helix-Turn-Helix DNA binding domain of the MerR1 transcription regulator; Region: HTH_MerR1; cd04783 266264000181 DNA binding residues [nucleotide binding] 266264000182 dimer interface [polypeptide binding]; other site 266264000183 mercury binding site [ion binding]; other site 266264000184 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 266264000185 dimerization domain [polypeptide binding]; other site 266264000186 dimer interface [polypeptide binding]; other site 266264000187 catalytic residues [active] 266264000188 Sex factor F TraW protein N terminal; Region: TraW_N; cl10149 266264000189 TraU protein; Region: TraU; pfam06834 266264000190 Type-F conjugative transfer system pilin assembly protein; Region: TrbC_Ftype; pfam09673 266264000191 Protein of unknown function (DUF3150); Region: DUF3150; pfam11348 266264000192 GIY-YIG nuclease domain superfamily; Region: GIY-YIG_SF; cl15257 266264000193 active site 266264000194 GIY-YIG motif/motif A; other site 266264000195 catalytic site [active] 266264000196 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 266264000197 Helix-turn-helix domain; Region: HTH_19; pfam12844 266264000198 flagellar hook-associated protein FlgL; Reviewed; Region: flgL; PRK08870 266264000199 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 266264000200 Uncharacterized protein conserved in bacteria (DUF2191); Region: DUF2191; pfam09957 266264000201 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 266264000202 non-specific DNA binding site [nucleotide binding]; other site 266264000203 salt bridge; other site 266264000204 sequence-specific DNA binding site [nucleotide binding]; other site 266264000205 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 266264000206 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 266264000207 Outer membrane efflux protein; Region: OEP; pfam02321 266264000208 heavy metal efflux pump, CzcA family; Region: 2A0601; TIGR00914 266264000209 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266264000210 H+ Antiporter protein; Region: 2A0121; TIGR00900 266264000211 putative substrate translocation pore; other site 266264000212 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182 266264000213 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 266264000214 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 266264000215 PAS domain; Region: PAS_9; pfam13426 266264000216 putative active site [active] 266264000217 heme pocket [chemical binding]; other site 266264000218 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 266264000219 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 266264000220 metal binding site [ion binding]; metal-binding site 266264000221 active site 266264000222 I-site; other site 266264000223 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 266264000224 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266264000225 Major Facilitator Superfamily; Region: MFS_1; pfam07690 266264000226 putative substrate translocation pore; other site 266264000227 Methyltransferase domain; Region: Methyltransf_23; pfam13489 266264000228 Methyltransferase domain; Region: Methyltransf_11; pfam08241 266264000229 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 266264000230 copper/silver efflux system membrane fusion protein CusB; Provisional; Region: PRK09783 266264000231 HlyD family secretion protein; Region: HlyD_3; pfam13437 266264000232 Copper binding periplasmic protein CusF; Region: CusF_Ec; pfam11604 266264000233 Outer membrane efflux protein; Region: OEP; pfam02321 266264000234 Uncharacterized conserved protein [Function unknown]; Region: COG2968 266264000235 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 266264000236 hypothetical protein; Provisional; Region: PRK08317 266264000237 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 266264000238 S-adenosylmethionine binding site [chemical binding]; other site 266264000239 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 266264000240 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 266264000241 Predicted membrane protein [Function unknown]; Region: COG2246 266264000242 GtrA-like protein; Region: GtrA; pfam04138 266264000243 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 266264000244 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 266264000245 Ligand binding site; other site 266264000246 Putative Catalytic site; other site 266264000247 DXD motif; other site 266264000248 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 266264000249 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 266264000250 trimer interface [polypeptide binding]; other site 266264000251 eyelet of channel; other site 266264000252 Protein of unknown function (DUF2933); Region: DUF2933; pfam11666 266264000253 YHS domain; Region: YHS; pfam04945 266264000254 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 266264000255 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 266264000256 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 266264000257 active site 266264000258 motif I; other site 266264000259 motif II; other site 266264000260 Protein of unknown function, DUF; Region: DUF411; cl01142 266264000261 putative heme-binding domain, Pirellula/Verrucomicrobium type; Region: CxxCH_TIGR02603 266264000262 Cytochrome c; Region: Cytochrom_C; pfam00034 266264000263 Uncharacterized copper-binding protein [Inorganic ion transport and metabolism]; Region: COG4454 266264000264 Copper resistance protein D; Region: CopD; cl00563 266264000265 CopC domain; Region: CopC; pfam04234 266264000266 Copper resistance protein B precursor (CopB); Region: CopB; pfam05275 266264000267 copper-resistance protein, CopA family; Region: copper_res_A; TIGR01480 266264000268 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 266264000269 Multicopper oxidase; Region: Cu-oxidase; pfam00394 266264000270 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 266264000271 DNA-binding transcriptional activator CusR; Provisional; Region: PRK09836 266264000272 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266264000273 active site 266264000274 phosphorylation site [posttranslational modification] 266264000275 intermolecular recognition site; other site 266264000276 dimerization interface [polypeptide binding]; other site 266264000277 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 266264000278 DNA binding site [nucleotide binding] 266264000279 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 266264000280 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 266264000281 dimerization interface [polypeptide binding]; other site 266264000282 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 266264000283 dimer interface [polypeptide binding]; other site 266264000284 phosphorylation site [posttranslational modification] 266264000285 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266264000286 ATP binding site [chemical binding]; other site 266264000287 Mg2+ binding site [ion binding]; other site 266264000288 G-X-G motif; other site 266264000289 Copper resistance protein K; Region: CopK; pfam11525 266264000290 Cytochrome c; Region: Cytochrom_C; pfam00034 266264000291 Uncharacterized protein conserved in bacteria (DUF2191); Region: DUF2191; pfam09957 266264000292 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cl17503 266264000293 Peptidase M30; Region: Peptidase_M30; pfam10460 266264000294 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cl00257 266264000295 IHF - DNA interface [nucleotide binding]; other site 266264000296 IHF dimer interface [polypeptide binding]; other site 266264000297 Phage integrase protein; Region: DUF3701; pfam12482 266264000298 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 266264000299 INT_SG1, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 1, C-terminal catalytic domain. The CD contains mainly predicted integrase/recombinase and site-specific XerD recombinases. The members of this CD are found predominantly in...; Region: INT_SG1_C; cd01183 266264000300 Int/Topo IB signature motif; other site 266264000301 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_4; pfam14281 266264000302 putative transposase OrfB; Reviewed; Region: PHA02517 266264000303 HTH-like domain; Region: HTH_21; pfam13276 266264000304 Integrase core domain; Region: rve; pfam00665 266264000305 Integrase core domain; Region: rve_3; pfam13683 266264000306 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 266264000307 Transposase; Region: HTH_Tnp_1; cl17663 266264000308 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 266264000309 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 266264000310 non-specific DNA binding site [nucleotide binding]; other site 266264000311 salt bridge; other site 266264000312 sequence-specific DNA binding site [nucleotide binding]; other site 266264000313 putative transposase OrfB; Reviewed; Region: PHA02517 266264000314 HTH-like domain; Region: HTH_21; pfam13276 266264000315 Integrase core domain; Region: rve; pfam00665 266264000316 Integrase core domain; Region: rve_3; pfam13683 266264000317 Uncharacterized ACR, COG2135; Region: DUF159; pfam02586 266264000318 plasmid partitioning protein RepA; Region: partition_RepA; TIGR03453 266264000319 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 266264000320 P-loop; other site 266264000321 Magnesium ion binding site [ion binding]; other site 266264000322 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 266264000323 Magnesium ion binding site [ion binding]; other site 266264000324 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 266264000325 ParB-like nuclease domain; Region: ParB; smart00470 266264000326 RES domain; Region: RES; pfam08808 266264000327 INT_SG1, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 1, C-terminal catalytic domain. The CD contains mainly predicted integrase/recombinase and site-specific XerD recombinases. The members of this CD are found predominantly in...; Region: INT_SG1_C; cd01183 266264000328 Int/Topo IB signature motif; other site 266264000329 Protein of unknown function (Hypoth_ymh); Region: Hypoth_Ymh; pfam09509 266264000330 Domain of unknown function (DUF4263); Region: DUF4263; pfam14082 266264000331 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 266264000332 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 266264000333 active site 266264000334 Integrase core domain; Region: rve; pfam00665 266264000335 AAA domain; Region: AAA_22; pfam13401 266264000336 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 266264000337 Walker A motif; other site 266264000338 ATP binding site [chemical binding]; other site 266264000339 Walker B motif; other site 266264000340 arginine finger; other site 266264000341 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 266264000342 Chlorite dismutase; Region: Chlor_dismutase; cl01280 266264000343 Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016 266264000344 putative transcriptional regulator MerR; Provisional; Region: PRK13752 266264000345 Helix-Turn-Helix DNA binding domain of the MerR1 transcription regulator; Region: HTH_MerR1; cd04783 266264000346 DNA binding residues [nucleotide binding] 266264000347 dimer interface [polypeptide binding]; other site 266264000348 mercury binding site [ion binding]; other site 266264000349 putative mercuric transport protein; Provisional; Region: PRK13751 266264000350 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 266264000351 metal-binding site [ion binding] 266264000352 putative mercuric reductase; Provisional; Region: PRK13748 266264000353 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 266264000354 metal-binding site [ion binding] 266264000355 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 266264000356 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 266264000357 transcriptional regulator MerD; Provisional; Region: PRK13749 266264000358 Helix-Turn-Helix DNA binding domain of the MerD transcription regulator; Region: HTH_MerD; cd01111 266264000359 DNA binding residues [nucleotide binding] 266264000360 putative dimer interface [polypeptide binding]; other site 266264000361 putative mercury resistance protein; Provisional; Region: PRK13747 266264000362 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 266264000363 Domain of unknown function (DUF3330); Region: DUF3330; pfam11809 266264000364 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 266264000365 multiple promoter invertase; Provisional; Region: mpi; PRK13413 266264000366 catalytic residues [active] 266264000367 catalytic nucleophile [active] 266264000368 Presynaptic Site I dimer interface [polypeptide binding]; other site 266264000369 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 266264000370 Synaptic Flat tetramer interface [polypeptide binding]; other site 266264000371 Synaptic Site I dimer interface [polypeptide binding]; other site 266264000372 DNA binding site [nucleotide binding] 266264000373 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 266264000374 DNA-binding interface [nucleotide binding]; DNA binding site 266264000375 Domain of unknown function (DUF4158); Region: DUF4158; pfam13700 266264000376 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; pfam01526 266264000377 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cl00257 266264000378 IHF - DNA interface [nucleotide binding]; other site 266264000379 IHF dimer interface [polypeptide binding]; other site 266264000380 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 266264000381 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235 266264000382 INT_SG1, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 1, C-terminal catalytic domain. The CD contains mainly predicted integrase/recombinase and site-specific XerD recombinases. The members of this CD are found predominantly in...; Region: INT_SG1_C; cd01183 266264000383 Int/Topo IB signature motif; other site 266264000384 Uncharacterized conserved protein [Function unknown]; Region: COG3391 266264000385 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 266264000386 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 266264000387 Domain of Unknown Function (DUF1259); Region: DUF1529; pfam07485 266264000388 Domain of Unknown Function (DUF1259); Region: DUF1529; pfam07485 266264000389 Major Facilitator Superfamily; Region: MFS_1; pfam07690 266264000390 Chromate resistance exported protein; Region: Chrome_Resist; pfam09828 266264000391 GlpE sulfurtransferase (ST) and homologs are members of the Rhodanese Homology Domain superfamily. Unlike other rhodanese sulfurtransferases, GlpE is a single domain protein but indications are that it functions as a dimer. The active site contains a...; Region: GlpE_ST; cd01444 266264000392 active site residue [active] 266264000393 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 266264000394 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 266264000395 Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059 266264000396 chromate transporter, chromate ion transporter (CHR) family; Region: 2A51; TIGR00937 266264000397 Chromate transporter; Region: Chromate_transp; pfam02417 266264000398 Chromate resistance exported protein; Region: Chrome_Resist; pfam09828 266264000399 Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640 266264000400 Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640 266264000401 Heavy-metal resistance; Region: Metal_resist; pfam13801 266264000402 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 266264000403 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 266264000404 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 266264000405 DNA binding residues [nucleotide binding] 266264000406 Outer membrane efflux protein; Region: OEP; pfam02321 266264000407 Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999 266264000408 HlyD family secretion protein; Region: HlyD_3; pfam13437 266264000409 heavy metal efflux pump, CzcA family; Region: 2A0601; TIGR00914 266264000410 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 266264000411 EamA-like transporter family; Region: EamA; pfam00892 266264000412 EamA-like transporter family; Region: EamA; pfam00892 266264000413 Domain of unknown function (DUF4158); Region: DUF4158; pfam13700 266264000414 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; cl14901 266264000415 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 266264000416 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 266264000417 Walker A/P-loop; other site 266264000418 ATP binding site [chemical binding]; other site 266264000419 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 266264000420 active site 266264000421 metal binding site [ion binding]; metal-binding site 266264000422 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 266264000423 phage/plasmid-like protein TIGR03299; Region: LGT_TIGR03299 266264000424 Glycine zipper 2TM domain; Region: Rick_17kDa_Anti; cl10470 266264000425 PRTRC system ThiF family protein; Region: PRTRC_ThiF; TIGR03736 266264000426 Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cd01483 266264000427 ATP binding site [chemical binding]; other site 266264000428 substrate interface [chemical binding]; other site 266264000429 Domain of unknown function (DUF2016); Region: DUF2016; pfam09436 266264000430 PRTRC system protein A; Region: PRTRC_A; TIGR03735 266264000431 Prokaryotic homologs of the JAB domain; Region: Prok-JAB; pfam14464 266264000432 PRTRC system protein B; Region: PRTRC_B; TIGR03737 266264000433 PRTRC system protein F; Region: PRTRC_F; TIGR03742 266264000434 Alpha-helical domain 2; Region: alpha-hel2; pfam14456 266264000435 PRTRC system protein C; Region: PRTRC_C; TIGR03738 266264000436 PRTRC system protein E; Region: PRTRC_E; TIGR03741 266264000437 ParB-like nuclease domain; Region: ParBc; pfam02195 266264000438 PRTRC system ParB family protein; Region: PRTRC_parB; TIGR03734 266264000439 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 266264000440 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 266264000441 Family description; Region: UvrD_C_2; pfam13538 266264000442 Protein of unknown function (DUF1173); Region: DUF1173; pfam06666 266264000443 Ftsk gamma domain; Region: Ftsk_gamma; cl09645 266264000444 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 266264000445 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235 266264000446 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 266264000447 active site 266264000448 catalytic residues [active] 266264000449 DNA binding site [nucleotide binding] 266264000450 Int/Topo IB signature motif; other site 266264000451 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 266264000452 DNA binding site [nucleotide binding] 266264000453 active site 266264000454 Int/Topo IB signature motif; other site 266264000455 catalytic residues [active] 266264000456 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 266264000457 active site 266264000458 catalytic residues [active] 266264000459 DNA binding site [nucleotide binding] 266264000460 Int/Topo IB signature motif; other site 266264000461 AAA ATPase domain; Region: AAA_16; pfam13191 266264000462 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 266264000463 RHS Repeat; Region: RHS_repeat; cl11982 266264000464 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 266264000465 IstB-like ATP binding N-terminal; Region: IstB_IS21_ATP; pfam08483 266264000466 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 266264000467 Walker A motif; other site 266264000468 ATP binding site [chemical binding]; other site 266264000469 Walker B motif; other site 266264000470 arginine finger; other site 266264000471 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 266264000472 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 266264000473 DNA binding residues [nucleotide binding] 266264000474 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 266264000475 Integrase core domain; Region: rve; pfam00665 266264000476 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 266264000477 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 266264000478 RHS Repeat; Region: RHS_repeat; cl11982 266264000479 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 266264000480 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 266264000481 RHS Repeat; Region: RHS_repeat; pfam05593 266264000482 RHS Repeat; Region: RHS_repeat; pfam05593 266264000483 RHS Repeat; Region: RHS_repeat; pfam05593 266264000484 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 266264000485 RHS Repeat; Region: RHS_repeat; pfam05593 266264000486 Phage protein Gp37/Gp68; Region: Gp37_Gp68; cl15384 266264000487 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; pfam01223 266264000488 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892 266264000489 active site 266264000490 substrate binding site [chemical binding]; other site 266264000491 Mg2+ binding site [ion binding]; other site 266264000492 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 266264000493 IHF dimer interface [polypeptide binding]; other site 266264000494 IHF - DNA interface [nucleotide binding]; other site 266264000495 Protein of unknown function (DUF1389); Region: DUF1389; pfam07146 266264000496 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 266264000497 active site 266264000498 catalytic residues [active] 266264000499 Int/Topo IB signature motif; other site 266264000500 DNA binding site [nucleotide binding] 266264000501 Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227 266264000502 PRTRC system protein D; Region: PRTRC_D; TIGR03739 266264000503 Mg binding site [ion binding]; other site 266264000504 nucleotide binding site [chemical binding]; other site 266264000505 putative protofilament interface [polypeptide binding]; other site 266264000506 Zinc-binding domain of primase-helicase; Region: Prim_Zn_Ribbon; smart00778 266264000507 Toprim domain; Region: Toprim_3; pfam13362 266264000508 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 266264000509 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 266264000510 dimer interface [polypeptide binding]; other site 266264000511 ssDNA binding site [nucleotide binding]; other site 266264000512 tetramer (dimer of dimers) interface [polypeptide binding]; other site 266264000513 type III secretion system protein SpaS; Validated; Region: PRK08156 266264000514 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 266264000515 Helix-turn-helix domain; Region: HTH_38; pfam13936 266264000516 Integrase core domain; Region: rve; pfam00665 266264000517 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 266264000518 PilS N terminal; Region: PilS; pfam08805 266264000519 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 266264000520 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 266264000521 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804 266264000522 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 266264000523 ATP binding site [chemical binding]; other site 266264000524 Walker B motif; other site 266264000525 type IVB pilus formation outer membrane protein, R64 PilN family; Region: pilus_B_mal_scr; TIGR02520 266264000526 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 266264000527 Toxin co-regulated pilus biosynthesis protein Q; Region: TcpQ; pfam10671 266264000528 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 266264000529 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 266264000530 N-acetyl-D-glucosamine binding site [chemical binding]; other site 266264000531 catalytic residue [active] 266264000532 VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cd06911 266264000533 VirB7 interaction site; other site 266264000534 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 266264000535 Bacterial conjugation TrbI-like protein; Region: TrbI; pfam03743 266264000536 VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cd06911 266264000537 VirB7 interaction site; other site 266264000538 VirB8 protein; Region: VirB8; pfam04335 266264000539 P-type DNA transfer ATPase VirB11; Region: VirB11; TIGR02788 266264000540 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 266264000541 Walker A motif; other site 266264000542 ATP binding site [chemical binding]; other site 266264000543 Walker B motif; other site 266264000544 Type IV secretory pathway, VirB3-like protein; Region: VirB3; cl01501 266264000545 type IV secretion/conjugal transfer ATPase, VirB4 family; Region: VirB4_CagE; TIGR00929 266264000546 CagE, TrbE, VirB family, component of type IV transporter system; Region: CagE_TrbE_VirB; pfam03135 266264000547 TraM recognition site of TraD and TraG; Region: TraG-D_C; cl17375 266264000548 Ribosomal protein S13/S18; Region: Ribosomal_S13; cl00331 266264000549 TrbL/VirB6 plasmid conjugal transfer protein; Region: TrbL; pfam04610 266264000550 integrating conjugative element relaxase, PFL_4751 family; Region: ICE_TraI_Pfluor; TIGR03760 266264000551 conjugative coupling factor TraD, SXT/TOL subfamily; Region: SXT_TraD; TIGR03743 266264000552 TraM recognition site of TraD and TraG; Region: TraG-D_C; cl17375 266264000553 Domain of unknown function (DUF4400); Region: DUF4400; pfam14348 266264000554 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 266264000555 Family description; Region: UvrD_C_2; pfam13538 266264000556 DnaA N-terminal domain; Region: DnaA_N; pfam11638 266264000557 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 266264000558 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 266264000559 Walker A motif; other site 266264000560 ATP binding site [chemical binding]; other site 266264000561 Walker B motif; other site 266264000562 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 266264000563 arginine finger; other site 266264000564 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 266264000565 DnaA box-binding interface [nucleotide binding]; other site 266264000566 DNA polymerase III subunit beta; Validated; Region: PRK05643 266264000567 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 266264000568 putative DNA binding surface [nucleotide binding]; other site 266264000569 dimer interface [polypeptide binding]; other site 266264000570 beta-clamp/clamp loader binding surface; other site 266264000571 beta-clamp/translesion DNA polymerase binding surface; other site 266264000572 DNA topoisomerase IV, B subunit, Gram-positive; Region: parE_Gpos; TIGR01058 266264000573 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266264000574 ATP binding site [chemical binding]; other site 266264000575 Mg2+ binding site [ion binding]; other site 266264000576 G-X-G motif; other site 266264000577 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 266264000578 anchoring element; other site 266264000579 dimer interface [polypeptide binding]; other site 266264000580 ATP binding site [chemical binding]; other site 266264000581 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 266264000582 active site 266264000583 putative metal-binding site [ion binding]; other site 266264000584 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 266264000585 Restriction endonuclease; Region: Mrr_cat; pfam04471 266264000586 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 266264000587 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 266264000588 active site 266264000589 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 266264000590 EamA-like transporter family; Region: EamA; pfam00892 266264000591 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 266264000592 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 266264000593 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 266264000594 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 266264000595 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266264000596 dimer interface [polypeptide binding]; other site 266264000597 conserved gate region; other site 266264000598 putative PBP binding loops; other site 266264000599 ABC-ATPase subunit interface; other site 266264000600 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266264000601 dimer interface [polypeptide binding]; other site 266264000602 conserved gate region; other site 266264000603 putative PBP binding loops; other site 266264000604 ABC-ATPase subunit interface; other site 266264000605 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 266264000606 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 266264000607 Walker A/P-loop; other site 266264000608 ATP binding site [chemical binding]; other site 266264000609 Q-loop/lid; other site 266264000610 ABC transporter signature motif; other site 266264000611 Walker B; other site 266264000612 D-loop; other site 266264000613 H-loop/switch region; other site 266264000614 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 266264000615 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 266264000616 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 266264000617 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in mouse RS21-C6 protein and its homologs; Region: NTP-PPase_RS21-C6_like; cd11537 266264000618 homodimer interface [polypeptide binding]; other site 266264000619 chemical substrate binding site [chemical binding]; other site 266264000620 oligomer interface [polypeptide binding]; other site 266264000621 metal binding site [ion binding]; metal-binding site 266264000622 Protein of unknown function DUF72; Region: DUF72; pfam01904 266264000623 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 266264000624 DEAD-like helicases superfamily; Region: DEXDc; smart00487 266264000625 ATP binding site [chemical binding]; other site 266264000626 putative Mg++ binding site [ion binding]; other site 266264000627 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623 266264000628 FOG: CBS domain [General function prediction only]; Region: COG0517 266264000629 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266264000630 putative substrate translocation pore; other site 266264000631 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 266264000632 catalytic residues [active] 266264000633 dimer interface [polypeptide binding]; other site 266264000634 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 266264000635 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 266264000636 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 266264000637 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 266264000638 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 266264000639 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 266264000640 metal binding site [ion binding]; metal-binding site 266264000641 putative dimer interface [polypeptide binding]; other site 266264000642 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 266264000643 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 266264000644 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 266264000645 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266264000646 Major Facilitator Superfamily; Region: MFS_1; pfam07690 266264000647 putative substrate translocation pore; other site 266264000648 glutamate carboxypeptidase; Reviewed; Region: PRK06133 266264000649 M20 Peptidase Glutamate carboxypeptidase, a periplasmic enzyme; Region: M20_CPDG2; cd03885 266264000650 metal binding site [ion binding]; metal-binding site 266264000651 dimer interface [polypeptide binding]; other site 266264000652 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 266264000653 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 266264000654 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266264000655 active site 266264000656 phosphorylation site [posttranslational modification] 266264000657 intermolecular recognition site; other site 266264000658 dimerization interface [polypeptide binding]; other site 266264000659 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 266264000660 DNA binding site [nucleotide binding] 266264000661 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 266264000662 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266264000663 active site 266264000664 phosphorylation site [posttranslational modification] 266264000665 intermolecular recognition site; other site 266264000666 dimerization interface [polypeptide binding]; other site 266264000667 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 266264000668 DNA binding site [nucleotide binding] 266264000669 outer membrane protein (porin) (fragment) 266264000670 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 266264000671 Transposase; Region: HTH_Tnp_1; cl17663 266264000672 putative transposase OrfB; Reviewed; Region: PHA02517 266264000673 HTH-like domain; Region: HTH_21; pfam13276 266264000674 Integrase core domain; Region: rve; pfam00665 266264000675 Integrase core domain; Region: rve_3; pfam13683 266264000676 outer membrane protein (porin) (fragment) 266264000677 cell division topological specificity factor MinE; Provisional; Region: PRK13989 266264000678 Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894 266264000679 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 266264000680 Switch I; other site 266264000681 Switch II; other site 266264000682 septum formation inhibitor; Reviewed; Region: PRK01973 266264000683 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 266264000684 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 266264000685 Mycobacterium tuberculosis CorA-like subfamily; Region: MtCorA-like; cd12830 266264000686 oligomer interface [polypeptide binding]; other site 266264000687 metal binding site [ion binding]; metal-binding site 266264000688 metal binding site [ion binding]; metal-binding site 266264000689 putative Cl binding site [ion binding]; other site 266264000690 basic sphincter; other site 266264000691 hydrophobic gate; other site 266264000692 periplasmic entrance; other site 266264000693 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 266264000694 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 266264000695 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 266264000696 potassium-transporting ATPase subunit C; Reviewed; Region: PRK00315 266264000697 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 266264000698 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 266264000699 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 266264000700 Ligand Binding Site [chemical binding]; other site 266264000701 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 266264000702 GAF domain; Region: GAF_3; pfam13492 266264000703 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 266264000704 phosphorylation site [posttranslational modification] 266264000705 dimer interface [polypeptide binding]; other site 266264000706 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266264000707 ATP binding site [chemical binding]; other site 266264000708 Mg2+ binding site [ion binding]; other site 266264000709 G-X-G motif; other site 266264000710 DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529 266264000711 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266264000712 active site 266264000713 phosphorylation site [posttranslational modification] 266264000714 intermolecular recognition site; other site 266264000715 dimerization interface [polypeptide binding]; other site 266264000716 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 266264000717 DNA binding site [nucleotide binding] 266264000718 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 266264000719 Sel1-like repeats; Region: SEL1; smart00671 266264000720 Sel1 repeat; Region: Sel1; pfam08238 266264000721 Sel1 repeat; Region: Sel1; cl02723 266264000722 A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; cl17448 266264000723 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 266264000724 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 266264000725 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 266264000726 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 266264000727 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 266264000728 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 266264000729 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 266264000730 GatB domain; Region: GatB_Yqey; smart00845 266264000731 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 266264000732 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 266264000733 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 266264000734 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 266264000735 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 266264000736 rod shape-determining protein MreB; Provisional; Region: PRK13927 266264000737 MreB and similar proteins; Region: MreB_like; cd10225 266264000738 nucleotide binding site [chemical binding]; other site 266264000739 Mg binding site [ion binding]; other site 266264000740 putative protofilament interaction site [polypeptide binding]; other site 266264000741 RodZ interaction site [polypeptide binding]; other site 266264000742 rod shape-determining protein MreC; Provisional; Region: PRK13922 266264000743 rod shape-determining protein MreC; Region: MreC; pfam04085 266264000744 Cell shape-determining protein [Cell envelope biogenesis, outer membrane]; Region: MreD; COG2891 266264000745 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 266264000746 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 266264000747 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 266264000748 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 266264000749 Protein of unknown function, DUF484; Region: DUF484; cl17449 266264000750 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 266264000751 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 266264000752 active site 266264000753 DNA binding site [nucleotide binding] 266264000754 Int/Topo IB signature motif; other site 266264000755 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 266264000756 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266264000757 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 266264000758 dimerization interface [polypeptide binding]; other site 266264000759 substrate binding pocket [chemical binding]; other site 266264000760 Protein of unknown function (DUF2917); Region: DUF2917; pfam11142 266264000761 lipoate-protein ligase B; Provisional; Region: PRK14343 266264000762 lipoyl synthase; Provisional; Region: PRK05481 266264000763 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 266264000764 FeS/SAM binding site; other site 266264000765 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 266264000766 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 266264000767 Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984 266264000768 Escherichia coli putative lactam utilization protein YbgL and similar proteins; Region: LamB_YcsF_YbgL_like; cd10800 266264000769 putative active site [active] 266264000770 Predicted membrane protein [Function unknown]; Region: COG3819 266264000771 Predicted membrane protein [Function unknown]; Region: COG3817 266264000772 Protein of unknown function (DUF979); Region: DUF979; pfam06166 266264000773 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 266264000774 putative substrate binding pocket [chemical binding]; other site 266264000775 AC domain interface; other site 266264000776 catalytic triad [active] 266264000777 AB domain interface; other site 266264000778 interchain disulfide; other site 266264000779 Predicted integral membrane protein [Function unknown]; Region: COG5652 266264000780 Protein of unknown function (DUF330); Region: DUF330; cl01135 266264000781 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 266264000782 mce related protein; Region: MCE; pfam02470 266264000783 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 266264000784 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 266264000785 Walker A/P-loop; other site 266264000786 ATP binding site [chemical binding]; other site 266264000787 Q-loop/lid; other site 266264000788 ABC transporter signature motif; other site 266264000789 Walker B; other site 266264000790 D-loop; other site 266264000791 H-loop/switch region; other site 266264000792 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 266264000793 Permease; Region: Permease; pfam02405 266264000794 biotin--protein ligase; Provisional; Region: PRK06955 266264000795 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 266264000796 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 266264000797 pantothenate kinase; Reviewed; Region: PRK13328 266264000798 Sporulation related domain; Region: SPOR; pfam05036 266264000799 rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199 266264000800 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 266264000801 active site 266264000802 nucleotide binding site [chemical binding]; other site 266264000803 HIGH motif; other site 266264000804 KMSKS motif; other site 266264000805 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 266264000806 dinuclear metal binding motif [ion binding]; other site 266264000807 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 266264000808 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209 266264000809 active site 266264000810 nucleophile elbow; other site 266264000811 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 266264000812 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 266264000813 substrate binding site [chemical binding]; other site 266264000814 oxyanion hole (OAH) forming residues; other site 266264000815 trimer interface [polypeptide binding]; other site 266264000816 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762 266264000817 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 266264000818 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 266264000819 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 266264000820 Transcriptional regulator [Transcription]; Region: IclR; COG1414 266264000821 Bacterial transcriptional regulator; Region: IclR; pfam01614 266264000822 Protein of unknown function (DUF3108); Region: DUF3108; pfam11306 266264000823 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 266264000824 Protein of unknown function (DUF3567); Region: DUF3567; pfam12091 266264000825 Member of the Rhodanese Homology Domain superfamily, subgroup 1. This CD includes the putative rhodanese-related sulfurtransferases of several uncharacterized proteins; Region: RHOD_1; cd01522 266264000826 active site residue [active] 266264000827 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 266264000828 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 266264000829 Methionine synthase I, cobalamin-binding domain [Amino acid transport and metabolism]; Region: MetH; COG1410 266264000830 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 266264000831 substrate binding pocket [chemical binding]; other site 266264000832 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 266264000833 B12 binding site [chemical binding]; other site 266264000834 cobalt ligand [ion binding]; other site 266264000835 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 266264000836 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 266264000837 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266264000838 active site 266264000839 phosphorylation site [posttranslational modification] 266264000840 intermolecular recognition site; other site 266264000841 dimerization interface [polypeptide binding]; other site 266264000842 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 266264000843 DNA binding residues [nucleotide binding] 266264000844 dimerization interface [polypeptide binding]; other site 266264000845 Response regulator receiver domain; Region: Response_reg; pfam00072 266264000846 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266264000847 active site 266264000848 phosphorylation site [posttranslational modification] 266264000849 intermolecular recognition site; other site 266264000850 dimerization interface [polypeptide binding]; other site 266264000851 Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG5278 266264000852 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 266264000853 Histidine kinase; Region: HisKA_3; pfam07730 266264000854 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266264000855 ATP binding site [chemical binding]; other site 266264000856 Mg2+ binding site [ion binding]; other site 266264000857 G-X-G motif; other site 266264000858 Domain of unknown function (DUF1840); Region: DUF1840; pfam08895 266264000859 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 266264000860 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 266264000861 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 266264000862 active site 266264000863 HIGH motif; other site 266264000864 KMSK motif region; other site 266264000865 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 266264000866 tRNA binding surface [nucleotide binding]; other site 266264000867 anticodon binding site; other site 266264000868 Sporulation related domain; Region: SPOR; pfam05036 266264000869 DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019 266264000870 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 266264000871 catalytic residues [active] 266264000872 hinge region; other site 266264000873 alpha helical domain; other site 266264000874 short chain dehydrogenase; Provisional; Region: PRK07024 266264000875 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266264000876 NAD(P) binding site [chemical binding]; other site 266264000877 active site 266264000878 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 266264000879 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 266264000880 intersubunit interface [polypeptide binding]; other site 266264000881 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 266264000882 Helix-Turn-Helix DNA binding domain of the regulatory protein GnyR; Region: HTH_GnyR; cd04776 266264000883 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 266264000884 DNA binding residues [nucleotide binding] 266264000885 putative dimer interface [polypeptide binding]; other site 266264000886 isovaleryl-CoA dehydrogenase; Region: PLN02519 266264000887 Isovaleryl-CoA dehydrogenase; Region: IVD; cd01156 266264000888 substrate binding site [chemical binding]; other site 266264000889 FAD binding site [chemical binding]; other site 266264000890 catalytic base [active] 266264000891 Isocitrate dehydrogenase kinase/phosphatase [Signal transduction mechanisms]; Region: COG4579 266264000892 bifunctional isocitrate dehydrogenase kinase/phosphatase protein; Validated; Region: aceK; PRK02946 266264000893 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883 266264000894 active site clefts [active] 266264000895 zinc binding site [ion binding]; other site 266264000896 dimer interface [polypeptide binding]; other site 266264000897 acetyl-CoA acetyltransferase; Provisional; Region: PRK06954 266264000898 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 266264000899 dimer interface [polypeptide binding]; other site 266264000900 active site 266264000901 carbonyl reductase sniffer-like, classical (c) SDRs; Region: carb_red_sniffer_like_SDR_c; cd05325 266264000902 C factor cell-cell signaling protein; Provisional; Region: PRK09009 266264000903 NADP binding site [chemical binding]; other site 266264000904 homodimer interface [polypeptide binding]; other site 266264000905 active site 266264000906 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 266264000907 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 266264000908 active site 266264000909 2-hydroxychromene-2-carboxylate isomerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NahD; COG3917 266264000910 DsbA family, 2-hydroxychromene-2-carboxylate (HCCA) isomerase subfamily; HCCA isomerase is a glutathione (GSH) dependent enzyme involved in the naphthalene catabolic pathway. It converts HCCA, a hemiketal formed spontaneously after ring cleavage of 1; Region: DsbA_HCCA_Iso; cd03022 266264000911 putative catalytic residue [active] 266264000912 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 266264000913 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 266264000914 motif II; other site 266264000915 hypothetical protein; Provisional; Region: PRK01842 266264000916 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 266264000917 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 266264000918 enoyl-CoA hydratase; Provisional; Region: PRK05995 266264000919 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 266264000920 substrate binding site [chemical binding]; other site 266264000921 oxyanion hole (OAH) forming residues; other site 266264000922 trimer interface [polypeptide binding]; other site 266264000923 adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK06943 266264000924 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 266264000925 inhibitor-cofactor binding pocket; inhibition site 266264000926 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266264000927 catalytic residue [active] 266264000928 8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958 266264000929 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 266264000930 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 266264000931 catalytic residue [active] 266264000932 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 266264000933 AAA domain; Region: AAA_26; pfam13500 266264000934 biotin synthase; Region: bioB; TIGR00433 266264000935 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 266264000936 FeS/SAM binding site; other site 266264000937 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 266264000938 bifunctional glyoxylate/hydroxypyruvate reductase A; Provisional; Region: ghrA; PRK15469 266264000939 Putative glycerate dehydrogenase and related proteins of the D-specific 2-hydroxy dehydrogenase family; Region: GDH_like_2; cd12164 266264000940 putative ligand binding site [chemical binding]; other site 266264000941 NAD binding site [chemical binding]; other site 266264000942 dimerization interface [polypeptide binding]; other site 266264000943 catalytic site [active] 266264000944 This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens ProX Ala-tRNA(Pro)...; Region: ProX_deacylase; cd04333 266264000945 putative deacylase active site [active] 266264000946 Protein of unknown function (DUF1289); Region: DUF1289; pfam06945 266264000947 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 266264000948 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 266264000949 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 266264000950 TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786 266264000951 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 266264000952 N-terminal plug; other site 266264000953 ligand-binding site [chemical binding]; other site 266264000954 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 266264000955 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 266264000956 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 266264000957 RNA polymerase-binding protein DksA; Region: dksA; TIGR02420 266264000958 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 266264000959 The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112 266264000960 P-loop, Walker A motif; other site 266264000961 Base recognition motif; other site 266264000962 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 266264000963 ferric uptake regulator; Provisional; Region: fur; PRK09462 266264000964 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 266264000965 metal binding site 2 [ion binding]; metal-binding site 266264000966 putative DNA binding helix; other site 266264000967 metal binding site 1 [ion binding]; metal-binding site 266264000968 dimer interface [polypeptide binding]; other site 266264000969 structural Zn2+ binding site [ion binding]; other site 266264000970 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 266264000971 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 266264000972 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 266264000973 active site 266264000974 HslU subunit interaction site [polypeptide binding]; other site 266264000975 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 266264000976 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 266264000977 Walker A motif; other site 266264000978 ATP binding site [chemical binding]; other site 266264000979 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 266264000980 Walker B motif; other site 266264000981 arginine finger; other site 266264000982 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 266264000983 Reeler-like domain of YcnI and similar proteins; Region: YcnI_like; cd08545 266264000984 Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain [Signal transduction mechanisms / Transcription]; Region: COG4567 266264000985 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266264000986 active site 266264000987 phosphorylation site [posttranslational modification] 266264000988 intermolecular recognition site; other site 266264000989 dimerization interface [polypeptide binding]; other site 266264000990 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 266264000991 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 266264000992 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266264000993 ATP binding site [chemical binding]; other site 266264000994 Mg2+ binding site [ion binding]; other site 266264000995 G-X-G motif; other site 266264000996 Protein of unknown function (DUF461); Region: DUF461; pfam04314 266264000997 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266264000998 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266264000999 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 266264001000 dimerization interface [polypeptide binding]; other site 266264001001 Cysteine-rich CWC; Region: Cys_rich_CWC; pfam14375 266264001002 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 266264001003 feedback inhibition sensing region; other site 266264001004 homohexameric interface [polypeptide binding]; other site 266264001005 nucleotide binding site [chemical binding]; other site 266264001006 N-acetyl-L-glutamate binding site [chemical binding]; other site 266264001007 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 266264001008 haloacid dehalogenase superfamily, subfamily IA hydrolase, TIGR01548; Region: HAD-SF-IA-hyp1 266264001009 division inhibitor protein; Provisional; Region: slmA; PRK09480 266264001010 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 266264001011 homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175 266264001012 homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392 266264001013 Methyltransferase domain; Region: Methyltransf_23; pfam13489 266264001014 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 266264001015 S-adenosylmethionine binding site [chemical binding]; other site 266264001016 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 266264001017 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 266264001018 PHB binding site; other site 266264001019 subunit interaction site [polypeptide binding]; other site 266264001020 CoenzymeA binding site [chemical binding]; other site 266264001021 muropeptide transporter; Validated; Region: ampG; cl17669 266264001022 muropeptide transporter; Reviewed; Region: ampG; PRK11902 266264001023 Peptidase family M48; Region: Peptidase_M48; pfam01435 266264001024 N-acetyl-gamma-glutamyl-phosphate reductase; Provisional; Region: PRK11863 266264001025 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 266264001026 Neisseria meningitides Nape-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Nape_like_AP-endo; cd10281 266264001027 putative active site [active] 266264001028 putative catalytic site [active] 266264001029 putative DNA binding site [nucleotide binding]; other site 266264001030 putative phosphate binding site [ion binding]; other site 266264001031 metal binding site A [ion binding]; metal-binding site 266264001032 putative AP binding site [nucleotide binding]; other site 266264001033 putative metal binding site B [ion binding]; other site 266264001034 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 266264001035 active site 266264001036 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 266264001037 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209 266264001038 active site 266264001039 nucleophile elbow; other site 266264001040 Patatin phospholipase; Region: DUF3734; pfam12536 266264001041 polyphosphate:nucleotide phosphotransferase, PPK2 family; Region: PPK2_rel_1; TIGR03709 266264001042 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 266264001043 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 266264001044 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 266264001045 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 266264001046 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 266264001047 putative acyl-acceptor binding pocket; other site 266264001048 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 266264001049 putative acyl-acceptor binding pocket; other site 266264001050 S-adenosylmethionine synthetase; Validated; Region: PRK05250 266264001051 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 266264001052 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 266264001053 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 266264001054 3-deoxy-D-manno-oct-2-ulosonic acid (Kdo) hydroxylase; Region: Kdo_hydroxy; pfam11004 266264001055 Coniferyl aldehyde dehydrogenase-like; Region: ALDH_CALDH_CalB; cd07133 266264001056 NAD(P) binding site [chemical binding]; other site 266264001057 catalytic residues [active] 266264001058 choline dehydrogenase; Validated; Region: PRK02106 266264001059 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 266264001060 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 266264001061 HAMP domain; Region: HAMP; pfam00672 266264001062 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 266264001063 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 266264001064 dimer interface [polypeptide binding]; other site 266264001065 putative CheW interface [polypeptide binding]; other site 266264001066 isovaleryl CoA dehydrogenase; Provisional; Region: PRK11561 266264001067 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 266264001068 active site 266264001070 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 266264001071 ThiC-associated domain; Region: ThiC-associated; pfam13667 266264001072 Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422 266264001073 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 266264001074 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 266264001075 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 266264001076 thiS-thiF/thiG interaction site; other site 266264001077 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 266264001078 ThiS interaction site; other site 266264001079 putative active site [active] 266264001080 tetramer interface [polypeptide binding]; other site 266264001081 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 266264001082 thiamine phosphate binding site [chemical binding]; other site 266264001083 active site 266264001084 pyrophosphate binding site [ion binding]; other site 266264001085 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 266264001086 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 266264001087 CoenzymeA binding site [chemical binding]; other site 266264001088 subunit interaction site [polypeptide binding]; other site 266264001089 PHB binding site; other site 266264001090 PGDYG protein; Region: PGDYG; pfam14083 266264001091 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 266264001092 dimer interface [polypeptide binding]; other site 266264001093 substrate binding site [chemical binding]; other site 266264001094 ATP binding site [chemical binding]; other site 266264001095 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 266264001096 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 266264001097 homotetramer interface [polypeptide binding]; other site 266264001098 ligand binding site [chemical binding]; other site 266264001099 catalytic site [active] 266264001100 NAD binding site [chemical binding]; other site 266264001101 Predicted membrane protein [Function unknown]; Region: COG1950 266264001102 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 266264001103 FAD binding site [chemical binding]; other site 266264001104 TfoX N-terminal domain; Region: TfoX_N; pfam04993 266264001105 Ub domain fused to Mut7-C; Region: Ub-Mut7C; pfam14451 266264001106 Uncharacterized conserved protein [Function unknown]; Region: COG1656 266264001107 Protein of unknown function DUF82; Region: DUF82; pfam01927 266264001108 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 266264001109 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 266264001110 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 266264001111 N-acetyl-D-glucosamine binding site [chemical binding]; other site 266264001112 catalytic residue [active] 266264001113 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, subunit 9, 39 kDa, (NDUFA9) -like, atypical (a) SDRs; Region: NDUFA9_like_SDR_a; cd05271 266264001114 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 266264001115 putative NAD(P) binding site [chemical binding]; other site 266264001116 active site 266264001117 GST_N family, unknown subfamily 1; composed of uncharacterized proteins, predominantly from bacteria, with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with...; Region: GST_N_1; cd03043 266264001118 putative C-terminal domain interface [polypeptide binding]; other site 266264001119 putative GSH binding site (G-site) [chemical binding]; other site 266264001120 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 266264001121 putative dimer interface [polypeptide binding]; other site 266264001122 C-terminal, alpha helical domain of an unknown subfamily 3 of Glutathione S-transferases; Region: GST_C_3; cd03194 266264001123 putative dimer interface [polypeptide binding]; other site 266264001124 putative N-terminal domain interface [polypeptide binding]; other site 266264001125 putative substrate binding pocket (H-site) [chemical binding]; other site 266264001126 multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase; Reviewed; Region: cca; PRK10885 266264001127 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 266264001128 active site 266264001129 NTP binding site [chemical binding]; other site 266264001130 metal binding triad [ion binding]; metal-binding site 266264001131 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 266264001132 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 266264001133 Zn2+ binding site [ion binding]; other site 266264001134 Mg2+ binding site [ion binding]; other site 266264001135 Protein of unknown function (DUF2905); Region: DUF2905; pfam11146 266264001136 Uncharacterized conserved protein [Function unknown]; Region: COG1565 266264001137 short chain dehydrogenase; Provisional; Region: PRK09134 266264001138 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266264001139 NAD(P) binding site [chemical binding]; other site 266264001140 active site 266264001141 Dihydroneopterin aldolase; Region: FolB; smart00905 266264001142 active site 266264001143 tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696 266264001144 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 266264001145 Ligand Binding Site [chemical binding]; other site 266264001146 N-acetylglucosamine-1-phosphate uridyltransferase (contains nucleotidyltransferase and I-patch acetyltransferase domains) [Cell envelope biogenesis, outer membrane]; Region: GlmU; COG1207 266264001147 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 266264001148 Substrate binding site; other site 266264001149 Mg++ binding site; other site 266264001150 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 266264001151 active site 266264001152 substrate binding site [chemical binding]; other site 266264001153 CoA binding site [chemical binding]; other site 266264001154 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 266264001155 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 266264001156 glutaminase active site [active] 266264001157 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 266264001158 dimer interface [polypeptide binding]; other site 266264001159 active site 266264001160 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 266264001161 dimer interface [polypeptide binding]; other site 266264001162 active site 266264001163 Tfp pilus assembly protein FimT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimT; COG4970 266264001164 Type II transport protein GspH; Region: GspH; pfam12019 266264001165 Tfp pilus assembly protein PilV [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilV; COG4967 266264001166 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 266264001167 Tfp pilus assembly protein PilW [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilW; COG4966 266264001168 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 266264001169 Tfp pilus assembly protein PilX [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilX; COG4726 266264001170 PilX N-terminal; Region: PilX_N; pfam14341 266264001171 Tfp pilus assembly protein, tip-associated adhesin PilY1 [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilY1; COG3419 266264001172 legume lectins; Region: lectin_L-type; cl14058 266264001173 homotetramer interaction site [polypeptide binding]; other site 266264001174 carbohydrate binding site [chemical binding]; other site 266264001175 metal binding site [ion binding]; metal-binding site 266264001176 Neisseria PilC beta-propeller domain; Region: Neisseria_PilC; pfam05567 266264001177 Tfp pilus assembly protein PilE [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilE; COG4968 266264001178 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 266264001179 dimerization interface [polypeptide binding]; other site 266264001180 active site 266264001181 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 266264001182 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 266264001183 heme binding site [chemical binding]; other site 266264001184 ferroxidase pore; other site 266264001185 ferroxidase diiron center [ion binding]; other site 266264001186 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 266264001187 Coenzyme A binding pocket [chemical binding]; other site 266264001188 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 266264001189 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 266264001190 NADP binding site [chemical binding]; other site 266264001191 dimer interface [polypeptide binding]; other site 266264001192 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 266264001193 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 266264001194 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266264001195 transcriptional activator TtdR; Provisional; Region: PRK09801 266264001196 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 266264001197 dimerization interface [polypeptide binding]; other site 266264001198 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 266264001199 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 266264001200 substrate binding site [chemical binding]; other site 266264001201 ligand binding site [chemical binding]; other site 266264001202 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 266264001203 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 266264001204 substrate binding site [chemical binding]; other site 266264001205 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 266264001206 Lipid A 3-O-deacylase (PagL); Region: PagL; pfam09411 266264001207 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 266264001208 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266264001209 DNA-binding site [nucleotide binding]; DNA binding site 266264001210 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 266264001211 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266264001212 homodimer interface [polypeptide binding]; other site 266264001213 catalytic residue [active] 266264001214 beta alanine--pyruvate transaminase; Provisional; Region: PRK09221 266264001215 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 266264001216 inhibitor-cofactor binding pocket; inhibition site 266264001217 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266264001218 catalytic residue [active] 266264001219 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 266264001220 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 266264001221 tetrameric interface [polypeptide binding]; other site 266264001222 NAD binding site [chemical binding]; other site 266264001223 catalytic residues [active] 266264001224 amino acid transporter; Region: 2A0306; TIGR00909 266264001225 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 266264001226 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 266264001227 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266264001228 DNA-binding site [nucleotide binding]; DNA binding site 266264001229 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 266264001230 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266264001231 homodimer interface [polypeptide binding]; other site 266264001232 catalytic residue [active] 266264001233 Protein of unknown function (DUF2917); Region: DUF2917; pfam11142 266264001234 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 266264001235 B12 binding site [chemical binding]; other site 266264001236 cobalt ligand [ion binding]; other site 266264001237 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 266264001238 Walker A; other site 266264001239 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, unknown subfamily 1; composed of uncharacterized bacterial proteins containing a C-terminal MCM domain. MCM catalyzes the isomerization of methylmalonyl-CoA to succinyl-CoA. The...; Region: MM_CoA_mutase_1; cd03678 266264001240 putative active site [active] 266264001241 putative substrate binding site [chemical binding]; other site 266264001242 putative coenzyme B12 binding site [chemical binding]; other site 266264001243 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 266264001244 HIT family signature motif; other site 266264001245 catalytic residue [active] 266264001246 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808 266264001247 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 266264001248 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 266264001249 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 266264001250 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 266264001251 ligand binding site [chemical binding]; other site 266264001252 flexible hinge region; other site 266264001253 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 266264001254 putative switch regulator; other site 266264001255 non-specific DNA interactions [nucleotide binding]; other site 266264001256 DNA binding site [nucleotide binding] 266264001257 sequence specific DNA binding site [nucleotide binding]; other site 266264001258 putative cAMP binding site [chemical binding]; other site 266264001259 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 266264001260 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 266264001261 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 266264001262 acyl-activating enzyme (AAE) consensus motif; other site 266264001263 putative AMP binding site [chemical binding]; other site 266264001264 putative active site [active] 266264001265 putative CoA binding site [chemical binding]; other site 266264001266 Pleckstrin homology-like domain; Region: PH-like; cl17171 266264001267 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 266264001268 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 266264001269 Walker A/P-loop; other site 266264001270 ATP binding site [chemical binding]; other site 266264001271 Q-loop/lid; other site 266264001272 ABC transporter signature motif; other site 266264001273 Walker B; other site 266264001274 D-loop; other site 266264001275 H-loop/switch region; other site 266264001276 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 266264001277 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 266264001278 TM-ABC transporter signature motif; other site 266264001279 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 266264001280 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 266264001281 TM-ABC transporter signature motif; other site 266264001282 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_1; cd06334 266264001283 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 266264001284 putative ligand binding site [chemical binding]; other site 266264001285 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 266264001286 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 266264001287 Walker A/P-loop; other site 266264001288 ATP binding site [chemical binding]; other site 266264001289 Q-loop/lid; other site 266264001290 ABC transporter signature motif; other site 266264001291 Walker B; other site 266264001292 D-loop; other site 266264001293 H-loop/switch region; other site 266264001294 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 266264001295 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 266264001296 acyl-activating enzyme (AAE) consensus motif; other site 266264001297 AMP binding site [chemical binding]; other site 266264001298 active site 266264001299 CoA binding site [chemical binding]; other site 266264001300 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2832 266264001301 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 266264001302 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 266264001303 FMN binding site [chemical binding]; other site 266264001304 substrate binding site [chemical binding]; other site 266264001305 putative catalytic residue [active] 266264001306 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 266264001307 Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase; Region: PUA; smart00359 266264001308 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 266264001309 putative RNA binding site [nucleotide binding]; other site 266264001310 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 266264001311 S-adenosylmethionine binding site [chemical binding]; other site 266264001312 hypothetical protein; Provisional; Region: PRK02047 266264001313 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 266264001314 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 266264001315 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 266264001316 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2945 266264001317 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 266264001318 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 266264001319 dimer interface [polypeptide binding]; other site 266264001320 [2Fe-2S] cluster binding site [ion binding]; other site 266264001321 C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663 266264001322 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 266264001323 Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191 266264001324 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 266264001325 dimer interface [polypeptide binding]; other site 266264001326 phosphorylation site [posttranslational modification] 266264001327 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266264001328 ATP binding site [chemical binding]; other site 266264001329 Mg2+ binding site [ion binding]; other site 266264001330 G-X-G motif; other site 266264001331 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 266264001332 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266264001333 active site 266264001334 phosphorylation site [posttranslational modification] 266264001335 intermolecular recognition site; other site 266264001336 dimerization interface [polypeptide binding]; other site 266264001337 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 266264001338 Walker A motif; other site 266264001339 ATP binding site [chemical binding]; other site 266264001340 Walker B motif; other site 266264001341 arginine finger; other site 266264001342 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 266264001343 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 266264001344 active sites [active] 266264001345 tetramer interface [polypeptide binding]; other site 266264001346 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 266264001347 Part of AAA domain; Region: AAA_19; pfam13245 266264001348 Family description; Region: UvrD_C_2; pfam13538 266264001349 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 266264001350 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 266264001351 catalytic residues [active] 266264001352 SoxW family; SoxW is a bacterial periplasmic TRX, containing a redox active CXXC motif, encoded by a genetic locus (sox operon) involved in thiosulfate oxidation. Sulfur bacteria oxidize sulfur compounds to provide reducing equivalents for carbon dioxide...; Region: SoxW; cd02951 266264001353 catalytic residues [active] 266264001354 LysE type translocator; Region: LysE; cl00565 266264001355 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 266264001356 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 266264001357 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 266264001358 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 266264001359 Membrane fusogenic activity; Region: BMFP; pfam04380 266264001360 Bacterial protein of unknown function (Gcw_chp); Region: Gcw_chp; pfam09694 266264001361 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 266264001362 Nitrogen regulatory protein P-II; Region: P-II; smart00938 266264001363 ammonium transporter; Provisional; Region: PRK10666 266264001364 Glutamate-cysteine ligase; Region: GshA; pfam08886 266264001365 glutamate--cysteine ligase, T. ferrooxidans family; Region: gshA_ferroox; TIGR02049 266264001366 glutathione synthetase; Provisional; Region: PRK05246 266264001367 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 266264001368 Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955 266264001369 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 266264001370 active pocket/dimerization site; other site 266264001371 active site 266264001372 phosphorylation site [posttranslational modification] 266264001373 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 266264001374 dimerization domain swap beta strand [polypeptide binding]; other site 266264001375 regulatory protein interface [polypeptide binding]; other site 266264001376 active site 266264001377 regulatory phosphorylation site [posttranslational modification]; other site 266264001378 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 266264001379 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 266264001380 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 266264001381 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 266264001382 Bacterioferritin-associated ferredoxin [Inorganic ion transport and metabolism]; Region: Bfd; COG2906 266264001383 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 266264001384 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 266264001385 heme binding site [chemical binding]; other site 266264001386 ferroxidase pore; other site 266264001387 ferroxidase diiron center [ion binding]; other site 266264001388 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 266264001389 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 266264001390 ATP binding site [chemical binding]; other site 266264001391 substrate interface [chemical binding]; other site 266264001392 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 266264001393 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 266264001394 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 266264001395 protein binding site [polypeptide binding]; other site 266264001396 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 266264001397 Catalytic dyad [active] 266264001398 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 266264001399 catalytic core [active] 266264001400 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 266264001401 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 266264001402 active site residue [active] 266264001403 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 266264001404 GSH binding site [chemical binding]; other site 266264001405 catalytic residues [active] 266264001406 N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655 266264001407 Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344 266264001408 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 266264001409 putative active site [active] 266264001410 putative NTP binding site [chemical binding]; other site 266264001411 putative nucleic acid binding site [nucleotide binding]; other site 266264001412 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 266264001413 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 266264001414 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 266264001415 active site 266264001416 preprotein translocase subunit SecB; Validated; Region: PRK05751 266264001417 SecA binding site; other site 266264001418 Preprotein binding site; other site 266264001419 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 266264001420 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 266264001421 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 266264001422 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 266264001423 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 266264001424 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 266264001425 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 266264001426 active site 266264001427 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 266264001428 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 266264001429 S-adenosylmethionine binding site [chemical binding]; other site 266264001430 Integral membrane protein (DUF2244); Region: DUF2244; pfam10003 266264001431 cytochrome c oxidase subunit II; Provisional; Region: COX2; MTH00140 266264001432 Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790 266264001433 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 266264001434 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 266264001435 Cytochrome c; Region: Cytochrom_C; pfam00034 266264001436 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 266264001437 Cytochrome C oxidase subunit I. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_I; cd01663 266264001438 Subunit I/III interface [polypeptide binding]; other site 266264001439 D-pathway; other site 266264001440 Subunit I/VIIc interface [polypeptide binding]; other site 266264001441 Subunit I/IV interface [polypeptide binding]; other site 266264001442 Subunit I/II interface [polypeptide binding]; other site 266264001443 Low-spin heme (heme a) binding site [chemical binding]; other site 266264001444 Subunit I/VIIa interface [polypeptide binding]; other site 266264001445 Subunit I/VIa interface [polypeptide binding]; other site 266264001446 Dimer interface; other site 266264001447 Putative water exit pathway; other site 266264001448 Binuclear center (heme a3/CuB) [ion binding]; other site 266264001449 K-pathway; other site 266264001450 Subunit I/Vb interface [polypeptide binding]; other site 266264001451 Putative proton exit pathway; other site 266264001452 Subunit I/VIb interface; other site 266264001453 Subunit I/VIc interface [polypeptide binding]; other site 266264001454 Electron transfer pathway; other site 266264001455 Subunit I/VIIIb interface [polypeptide binding]; other site 266264001456 Subunit I/VIIb interface [polypeptide binding]; other site 266264001457 cytochrome C oxidase assembly protein; Provisional; Region: PRK05089 266264001458 Protein of unknown function (DUF2970); Region: DUF2970; pfam11174 266264001459 Cytochrome c oxidase subunit III. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_III; cd01665 266264001460 Subunit III/VIIa interface [polypeptide binding]; other site 266264001461 Phospholipid binding site [chemical binding]; other site 266264001462 Subunit I/III interface [polypeptide binding]; other site 266264001463 Subunit III/VIb interface [polypeptide binding]; other site 266264001464 Subunit III/VIa interface; other site 266264001465 Subunit III/Vb interface [polypeptide binding]; other site 266264001466 Protein of unknown function (DUF2909); Region: DUF2909; pfam11137 266264001467 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 266264001468 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 266264001469 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 266264001470 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 266264001471 UbiA prenyltransferase family; Region: UbiA; pfam01040 266264001472 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 266264001473 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 266264001474 Cu(I) binding site [ion binding]; other site 266264001475 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 266264001476 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 266264001477 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 266264001478 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 266264001479 DNA binding residues [nucleotide binding] 266264001480 Pirin-related protein [General function prediction only]; Region: COG1741 266264001481 Pirin; Region: Pirin; pfam02678 266264001482 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 266264001483 glycosyl transferase family protein; Provisional; Region: PRK08136 266264001484 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 266264001485 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 266264001486 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 266264001487 Walker A/P-loop; other site 266264001488 ATP binding site [chemical binding]; other site 266264001489 Q-loop/lid; other site 266264001490 ABC transporter signature motif; other site 266264001491 Walker B; other site 266264001492 D-loop; other site 266264001493 H-loop/switch region; other site 266264001494 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 266264001495 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266264001496 dimer interface [polypeptide binding]; other site 266264001497 conserved gate region; other site 266264001498 putative PBP binding loops; other site 266264001499 ABC-ATPase subunit interface; other site 266264001500 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 266264001501 NMT1-like family; Region: NMT1_2; pfam13379 266264001502 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 266264001503 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 266264001504 active site 266264001505 phosphorylation site [posttranslational modification] 266264001506 intermolecular recognition site; other site 266264001507 ANTAR domain; Region: ANTAR; pfam03861 266264001508 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 266264001509 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 266264001510 maleylacetoacetate isomerase; Region: maiA; TIGR01262 266264001511 GST_N family, Class Zeta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Zeta; cd03042 266264001512 C-terminal domain interface [polypeptide binding]; other site 266264001513 GSH binding site (G-site) [chemical binding]; other site 266264001514 putative dimer interface [polypeptide binding]; other site 266264001515 C-terminal, alpha helical domain of Class Zeta Glutathione S-transferases; Region: GST_C_Zeta; cd03191 266264001516 dimer interface [polypeptide binding]; other site 266264001517 N-terminal domain interface [polypeptide binding]; other site 266264001518 maleylacetoacetate (MAA) substrate binding site (H site) [chemical binding]; other site 266264001519 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 266264001520 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 266264001521 P loop; other site 266264001522 GTP binding site [chemical binding]; other site 266264001523 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 266264001524 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 266264001525 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 266264001526 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 266264001527 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 266264001528 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 266264001529 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 266264001530 S-adenosylmethionine binding site [chemical binding]; other site 266264001531 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 266264001532 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 266264001533 active site 266264001534 (T/H)XGH motif; other site 266264001535 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 266264001536 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 266264001537 putative active site [active] 266264001538 catalytic residue [active] 266264001539 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 266264001540 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 266264001541 5S rRNA interface [nucleotide binding]; other site 266264001542 CTC domain interface [polypeptide binding]; other site 266264001543 L16 interface [polypeptide binding]; other site 266264001544 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 266264001545 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 266264001546 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 266264001547 active site 266264001548 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00343 266264001549 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 266264001550 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 266264001551 outer membrane lipoprotein LolB; Provisional; Region: lolB; PRK00022 266264001552 Outer membrane lipoprotein LolB; Region: LolB; pfam03550 266264001553 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 266264001554 TPR motif; other site 266264001555 binding surface 266264001556 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 266264001557 binding surface 266264001558 TPR motif; other site 266264001559 TPR repeat; Region: TPR_11; pfam13414 266264001560 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 266264001561 binding surface 266264001562 TPR motif; other site 266264001563 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 266264001564 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 266264001565 DNA binding site [nucleotide binding] 266264001566 catalytic residue [active] 266264001567 H2TH interface [polypeptide binding]; other site 266264001568 putative catalytic residues [active] 266264001569 turnover-facilitating residue; other site 266264001570 intercalation triad [nucleotide binding]; other site 266264001571 8OG recognition residue [nucleotide binding]; other site 266264001572 putative reading head residues; other site 266264001573 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 266264001574 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 266264001575 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 266264001576 Dynamin family; Region: Dynamin_N; pfam00350 266264001577 G1 box; other site 266264001578 GTP/Mg2+ binding site [chemical binding]; other site 266264001579 G2 box; other site 266264001580 Switch I region; other site 266264001581 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 266264001582 G3 box; other site 266264001583 Switch II region; other site 266264001584 GTP/Mg2+ binding site [chemical binding]; other site 266264001585 G4 box; other site 266264001586 G5 box; other site 266264001587 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 266264001588 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 266264001589 minor groove reading motif; other site 266264001590 helix-hairpin-helix signature motif; other site 266264001591 substrate binding pocket [chemical binding]; other site 266264001592 active site 266264001593 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 266264001594 DNA binding and oxoG recognition site [nucleotide binding] 266264001595 ATP-dependent protease La (LON) domain; Region: LON; pfam02190 266264001596 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 266264001597 psiF repeat; Region: PsiF_repeat; pfam07769 266264001598 psiF repeat; Region: PsiF_repeat; pfam07769 266264001599 HPr kinase/phosphorylase; Provisional; Region: PRK05428 266264001600 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 266264001601 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 266264001602 Hpr binding site; other site 266264001603 active site 266264001604 homohexamer subunit interaction site [polypeptide binding]; other site 266264001605 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 266264001606 active site 266264001607 phosphorylation site [posttranslational modification] 266264001608 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 266264001609 30S subunit binding site; other site 266264001610 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 266264001611 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 266264001612 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 266264001613 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 266264001614 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 266264001615 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 266264001616 Walker A/P-loop; other site 266264001617 ATP binding site [chemical binding]; other site 266264001618 Q-loop/lid; other site 266264001619 ABC transporter signature motif; other site 266264001620 Walker B; other site 266264001621 D-loop; other site 266264001622 H-loop/switch region; other site 266264001623 lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002 266264001624 OstA-like protein; Region: OstA; pfam03968 266264001625 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3117 266264001626 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 266264001627 D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892 266264001628 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 266264001629 putative active site [active] 266264001630 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 266264001631 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 266264001632 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 266264001633 Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226 266264001634 TrkA-N domain; Region: TrkA_N; pfam02254 266264001635 TrkA-C domain; Region: TrkA_C; pfam02080 266264001636 Uncharacterized protein related to arylsulfate sulfotransferase involved in siderophore biosynthesis [General function prediction only]; Region: COG4321 266264001637 intracellular protease, PfpI family; Region: PfpI; TIGR01382 266264001638 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_1; cd03169 266264001639 conserved cys residue [active] 266264001640 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 266264001641 active site 266264001642 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 266264001643 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 266264001644 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 266264001645 PhoU domain; Region: PhoU; pfam01895 266264001646 PhoU domain; Region: PhoU; pfam01895 266264001647 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 266264001648 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 266264001649 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 266264001650 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 266264001651 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266264001652 Major Facilitator Superfamily; Region: MFS_1; pfam07690 266264001653 putative substrate translocation pore; other site 266264001654 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 266264001655 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 266264001656 dimer interface [polypeptide binding]; other site 266264001657 ssDNA binding site [nucleotide binding]; other site 266264001658 tetramer (dimer of dimers) interface [polypeptide binding]; other site 266264001659 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 266264001660 DNA binding site [nucleotide binding] 266264001661 Int/Topo IB signature motif; other site 266264001662 active site 266264001663 catalytic residues [active] 266264001664 tyrosine-based site-specific recombinase (integrase) (partial) 266264001665 AAA domain; Region: AAA_22; pfam13401 266264001666 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 266264001667 Walker A motif; other site 266264001668 ATP binding site [chemical binding]; other site 266264001669 Walker B motif; other site 266264001670 arginine finger; other site 266264001671 Integrase core domain; Region: rve; pfam00665 266264001672 tyrosine-based site specific recombinase (partial) 266264001673 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 266264001674 Phage-related tail protein [Function unknown]; Region: COG5283 266264001675 arsenical resistance protein ArsH; Region: resist_ArsH; TIGR02690 266264001676 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 266264001677 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 266264001678 ArsC family; Region: ArsC; pfam03960 266264001679 catalytic residues [active] 266264001680 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 266264001681 Sodium Bile acid symporter family; Region: SBF; cl17470 266264001682 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 266264001683 Low molecular weight phosphatase family; Region: LMWPc; cd00115 266264001684 active site 266264001685 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_20; cd07254 266264001686 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 266264001687 putative metal binding site [ion binding]; other site 266264001688 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 266264001689 putative DNA binding site [nucleotide binding]; other site 266264001690 putative Zn2+ binding site [ion binding]; other site 266264001691 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 266264001692 S-adenosylmethionine binding site [chemical binding]; other site 266264001693 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 266264001694 substrate binding pocket [chemical binding]; other site 266264001695 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 266264001696 N-acetyl-D-glucosamine binding site [chemical binding]; other site 266264001697 catalytic residue [active] 266264001698 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 266264001699 Transcriptional regulator [Transcription]; Region: IclR; COG1414 266264001700 Bacterial transcriptional regulator; Region: IclR; pfam01614 266264001701 Bacterial transcriptional regulator; Region: IclR; pfam01614 266264001702 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 266264001703 FAD-dependent oxidoreductase; Provisional; Region: PRK08132 266264001704 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 266264001705 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 266264001706 Protein of unknown function (DUF2783); Region: DUF2783; pfam10932 266264001707 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 266264001708 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266264001709 putative substrate translocation pore; other site 266264001710 glutamate and aspartate transporter subunit; Provisional; Region: PRK10797 266264001711 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 266264001712 substrate binding pocket [chemical binding]; other site 266264001713 membrane-bound complex binding site; other site 266264001714 hinge residues; other site 266264001715 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 266264001716 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 266264001717 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 266264001718 putative active site [active] 266264001719 hypothetical protein; Provisional; Region: PRK07483 266264001720 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 266264001721 inhibitor-cofactor binding pocket; inhibition site 266264001722 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266264001723 catalytic residue [active] 266264001724 Prokaryotic protein of unknown function (DUF849); Region: DUF849; pfam05853 266264001725 aspartate aminotransferase; Provisional; Region: PRK06108 266264001726 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 266264001727 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266264001728 homodimer interface [polypeptide binding]; other site 266264001729 catalytic residue [active] 266264001730 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 266264001731 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 266264001732 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 266264001733 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 266264001734 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 266264001735 Walker A/P-loop; other site 266264001736 ATP binding site [chemical binding]; other site 266264001737 Q-loop/lid; other site 266264001738 ABC transporter signature motif; other site 266264001739 Walker B; other site 266264001740 D-loop; other site 266264001741 H-loop/switch region; other site 266264001742 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 266264001743 HlyD family secretion protein; Region: HlyD_3; pfam13437 266264001744 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 266264001745 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 266264001746 Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966 266264001747 7-cyano-7-deazaguanine reductase; Provisional; Region: queF; PRK11792 266264001748 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2904 266264001749 Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780 266264001750 threonine dehydratase; Reviewed; Region: PRK09224 266264001751 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 266264001752 tetramer interface [polypeptide binding]; other site 266264001753 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266264001754 catalytic residue [active] 266264001755 First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906 266264001756 putative Ile/Val binding site [chemical binding]; other site 266264001757 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 266264001758 putative Ile/Val binding site [chemical binding]; other site 266264001759 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105 266264001760 HAD-superfamily hydrolase, subfamily IIB; Region: HAD-SF-IIB; TIGR01484 266264001761 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 266264001762 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 266264001763 alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400 266264001764 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 266264001765 active site 266264001766 homotetramer interface [polypeptide binding]; other site 266264001767 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 266264001768 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 266264001769 Ligand binding site; other site 266264001770 metal-binding site 266264001771 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 266264001772 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 266264001773 XdhC Rossmann domain; Region: XdhC_C; pfam13478 266264001774 Carbon monoxide dehydrogenase subunit G (CoxG); Region: CoxG; cd05018 266264001775 putative hydrophobic ligand binding site [chemical binding]; other site 266264001776 Protein containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: CoxE; COG3552 266264001777 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 266264001778 metal ion-dependent adhesion site (MIDAS); other site 266264001779 MoxR-like ATPases [General function prediction only]; Region: COG0714 266264001780 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 266264001781 Walker A motif; other site 266264001782 ATP binding site [chemical binding]; other site 266264001783 Walker B motif; other site 266264001784 arginine finger; other site 266264001785 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 266264001786 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 266264001787 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 266264001788 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 266264001789 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 266264001790 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 266264001791 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 266264001792 catalytic loop [active] 266264001793 iron binding site [ion binding]; other site 266264001794 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 266264001795 Predicted membrane protein [Function unknown]; Region: COG1238 266264001796 Protein of unknown function (DUF3683); Region: DUF3683; pfam12447 266264001797 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 266264001798 FAD binding domain; Region: FAD_binding_4; pfam01565 266264001799 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 266264001800 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 266264001801 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 266264001802 Cysteine-rich domain; Region: CCG; pfam02754 266264001803 Domain of unknown function (DUF3400); Region: DUF3400; pfam11880 266264001804 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 266264001805 HIT family signature motif; other site 266264001806 catalytic residue [active] 266264001807 ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178 266264001808 ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549 266264001809 ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223 266264001810 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3536 266264001811 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 266264001812 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 266264001813 S-adenosylmethionine binding site [chemical binding]; other site 266264001814 Tim44 is an essential component of the machinery that mediates the translocation of nuclear-encoded proteins across the mitochondrial inner membrane; Region: Tim44; smart00978 266264001815 SCP-2 sterol transfer family; Region: SCP2; pfam02036 266264001816 putative ubiquinone biosynthesis protein UbiB; Reviewed; Region: ubiB; PRK04750 266264001817 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 266264001818 Na(+)- and Cl(-)-dependent choline cotransporter CHT and related proteins; solute-binding domain; Region: SLC5sbd_CHT; cd11474 266264001819 Na binding site [ion binding]; other site 266264001820 putative glycosylation site [posttranslational modification]; other site 266264001821 putative glycosylation site [posttranslational modification]; other site 266264001822 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993 266264001823 Uncharacterized conserved protein [Function unknown]; Region: COG2928 266264001824 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 266264001825 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 266264001826 dimer interface [polypeptide binding]; other site 266264001827 anticodon binding site; other site 266264001828 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 266264001829 homodimer interface [polypeptide binding]; other site 266264001830 motif 1; other site 266264001831 active site 266264001832 motif 2; other site 266264001833 GAD domain; Region: GAD; pfam02938 266264001834 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 266264001835 motif 3; other site 266264001836 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_7; cd04664 266264001837 nudix motif; other site 266264001838 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 266264001839 putative catalytic site [active] 266264001840 putative metal binding site [ion binding]; other site 266264001841 putative phosphate binding site [ion binding]; other site 266264001842 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116 266264001843 Walker A motif; other site 266264001844 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 266264001845 PLD-like domain; Region: PLDc_2; pfam13091 266264001846 putative active site [active] 266264001847 catalytic site [active] 266264001848 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase ybhO and similar proteins; Region: PLDc_ybhO_like_2; cd09159 266264001849 PLD-like domain; Region: PLDc_2; pfam13091 266264001850 putative active site [active] 266264001851 catalytic site [active] 266264001852 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 266264001853 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 266264001854 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 266264001855 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 266264001856 Putative acyl-CoA dehydrogenases similar to fadE5; Region: ACAD_fadE5; cd01153 266264001857 FAD binding site [chemical binding]; other site 266264001858 substrate binding site [chemical binding]; other site 266264001859 catalytic residues [active] 266264001860 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 266264001861 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 266264001862 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 266264001863 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 266264001864 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 266264001865 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 266264001866 substrate binding site [chemical binding]; other site 266264001867 oxyanion hole (OAH) forming residues; other site 266264001868 acetyl-CoA acetyltransferase; Provisional; Region: PRK09052 266264001869 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 266264001870 dimer interface [polypeptide binding]; other site 266264001871 active site 266264001872 Uncharacterized protein conserved in bacteria [Function unknown]; Region: DegV; COG1307 266264001873 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 266264001874 enoyl-CoA hydratase; Provisional; Region: PRK06688 266264001875 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 266264001876 substrate binding site [chemical binding]; other site 266264001877 oxyanion hole (OAH) forming residues; other site 266264001878 trimer interface [polypeptide binding]; other site 266264001879 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 266264001880 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 266264001881 ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265 266264001882 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 266264001883 Walker A/P-loop; other site 266264001884 ATP binding site [chemical binding]; other site 266264001885 Q-loop/lid; other site 266264001886 ABC transporter signature motif; other site 266264001887 Walker B; other site 266264001888 D-loop; other site 266264001889 H-loop/switch region; other site 266264001890 NMT1/THI5 like; Region: NMT1; pfam09084 266264001891 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 266264001892 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 266264001893 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 266264001894 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 266264001895 Walker A/P-loop; other site 266264001896 ATP binding site [chemical binding]; other site 266264001897 Q-loop/lid; other site 266264001898 ABC transporter signature motif; other site 266264001899 Walker B; other site 266264001900 D-loop; other site 266264001901 H-loop/switch region; other site 266264001902 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 266264001903 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266264001904 dimer interface [polypeptide binding]; other site 266264001905 conserved gate region; other site 266264001906 putative PBP binding loops; other site 266264001907 ABC-ATPase subunit interface; other site 266264001908 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 266264001909 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 266264001910 putative DNA binding site [nucleotide binding]; other site 266264001911 putative Zn2+ binding site [ion binding]; other site 266264001912 AsnC family; Region: AsnC_trans_reg; pfam01037 266264001913 Predicted metal-dependent enzyme of the double-stranded beta helix superfamily [General function prediction only]; Region: COG5553 266264001914 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266264001915 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 266264001916 dimerization interface [polypeptide binding]; other site 266264001917 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 266264001918 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 266264001919 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 266264001920 NAD(P) binding site [chemical binding]; other site 266264001921 glutamate and aspartate transporter subunit; Provisional; Region: PRK10797 266264001922 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 266264001923 substrate binding pocket [chemical binding]; other site 266264001924 membrane-bound complex binding site; other site 266264001925 hinge residues; other site 266264001926 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 266264001927 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266264001928 dimer interface [polypeptide binding]; other site 266264001929 conserved gate region; other site 266264001930 putative PBP binding loops; other site 266264001931 ABC-ATPase subunit interface; other site 266264001932 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 266264001933 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266264001934 dimer interface [polypeptide binding]; other site 266264001935 conserved gate region; other site 266264001936 putative PBP binding loops; other site 266264001937 ABC-ATPase subunit interface; other site 266264001938 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 266264001939 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 266264001940 Walker A/P-loop; other site 266264001941 ATP binding site [chemical binding]; other site 266264001942 Q-loop/lid; other site 266264001943 ABC transporter signature motif; other site 266264001944 Walker B; other site 266264001945 D-loop; other site 266264001946 H-loop/switch region; other site 266264001947 Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121 266264001948 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 266264001949 putative active site [active] 266264001950 putative dimer interface [polypeptide binding]; other site 266264001951 tartrate dehydrogenase; Region: TTC; TIGR02089 266264001952 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 266264001953 Putative glycerate kinase [Carbohydrate transport and metabolism]; Region: GckA; COG2379 266264001954 Domain of unknown function (DUF4147); Region: DUF4147; pfam13660 266264001955 MOFRL family; Region: MOFRL; pfam05161 266264001956 Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294 266264001957 active site 266264001958 substrate binding pocket [chemical binding]; other site 266264001959 dimer interface [polypeptide binding]; other site 266264001960 Protein of unknown function (DUF3025); Region: DUF3025; pfam11227 266264001961 OsmC-like protein; Region: OsmC; cl00767 266264001962 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 266264001963 23S rRNA interface [nucleotide binding]; other site 266264001964 L3 interface [polypeptide binding]; other site 266264001965 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 266264001966 Integral membrane protein CcmA involved in cell shape determination [Cell envelope biogenesis, outer membrane]; Region: CcmA; COG1664 266264001967 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 266264001968 iron-sulfur cluster insertion protein ErpA; Provisional; Region: PRK13623 266264001969 anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585 266264001970 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 266264001971 Peptidase family M23; Region: Peptidase_M23; pfam01551 266264001972 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 266264001973 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 266264001974 active site 266264001975 HIGH motif; other site 266264001976 dimer interface [polypeptide binding]; other site 266264001977 KMSKS motif; other site 266264001978 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 266264001979 RNA binding surface [nucleotide binding]; other site 266264001980 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 266264001981 putative active site [active] 266264001982 dimerization interface [polypeptide binding]; other site 266264001983 putative tRNAtyr binding site [nucleotide binding]; other site 266264001984 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 266264001985 substrate binding site [chemical binding]; other site 266264001986 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 266264001987 catalytic core [active] 266264001988 The SYLF domain (also called DUF500), a novel lipid-binding module; Region: SYLF; cd11524 266264001989 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 266264001990 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 266264001991 Walker A motif; other site 266264001992 ATP binding site [chemical binding]; other site 266264001993 Walker B motif; other site 266264001994 arginine finger; other site 266264001995 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 266264001996 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 266264001997 RuvA N terminal domain; Region: RuvA_N; pfam01330 266264001998 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 266264001999 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 266264002000 Glycerophosphodiester phosphodiesterase domain of Streptomycin coelicolor (GlpQ1) and similar proteins; Region: GDPD_ScGlpQ1_like; cd08602 266264002001 putative active site [active] 266264002002 catalytic site [active] 266264002003 putative metal binding site [ion binding]; other site 266264002004 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 266264002005 active site 266264002006 putative DNA-binding cleft [nucleotide binding]; other site 266264002007 dimer interface [polypeptide binding]; other site 266264002008 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 266264002009 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 266264002010 purine monophosphate binding site [chemical binding]; other site 266264002011 dimer interface [polypeptide binding]; other site 266264002012 putative catalytic residues [active] 266264002013 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 266264002014 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 266264002015 DNA-binding protein Fis; Provisional; Region: PRK01905 266264002016 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 266264002017 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 266264002018 FMN binding site [chemical binding]; other site 266264002019 active site 266264002020 catalytic residues [active] 266264002021 substrate binding site [chemical binding]; other site 266264002022 hypothetical protein; Provisional; Region: PRK06996 266264002023 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 266264002024 Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195 266264002025 proline aminopeptidase P II; Provisional; Region: PRK10879 266264002026 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 266264002027 active site 266264002028 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 266264002029 NTP_transferase_like_1 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_1; cd06422 266264002030 Substrate binding site; other site 266264002031 metal-binding site 266264002032 Predicted membrane protein [Function unknown]; Region: COG4392 266264002033 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 266264002034 Predicted phosphotransferase related to Ser/Thr protein kinases [General function prediction only]; Region: COG3178 266264002035 Phosphotransferase enzyme family; Region: APH; pfam01636 266264002036 OstA-like protein; Region: OstA; cl00844 266264002037 Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452 266264002038 OstA-like protein; Region: OstA; cl00844 266264002039 Organic solvent tolerance protein; Region: OstA_C; pfam04453 266264002040 SurA N-terminal domain; Region: SurA_N; pfam09312 266264002041 peptidyl-prolyl cis-trans isomerase SurA; Provisional; Region: PRK10770 266264002042 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 266264002043 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 266264002044 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK01909 266264002045 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 266264002046 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 266264002047 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 266264002048 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 266264002049 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 266264002050 active site 266264002051 HIGH motif; other site 266264002052 dimer interface [polypeptide binding]; other site 266264002053 KMSKS motif; other site 266264002054 putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272 266264002055 EamA-like transporter family; Region: EamA; pfam00892 266264002056 EamA-like transporter family; Region: EamA; pfam00892 266264002057 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 266264002058 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 266264002059 dimer interface [polypeptide binding]; other site 266264002060 active site 266264002061 metal binding site [ion binding]; metal-binding site 266264002062 glutathione binding site [chemical binding]; other site 266264002063 Protein of unknown function DUF45; Region: DUF45; pfam01863 266264002064 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 266264002065 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 266264002066 putative acyl-acceptor binding pocket; other site 266264002067 D,D-heptose 1,7-bisphosphate phosphatase; Validated; Region: PRK08942 266264002068 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 266264002069 active site 266264002070 motif I; other site 266264002071 motif II; other site 266264002072 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 266264002073 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 266264002074 dimer interface [polypeptide binding]; other site 266264002075 motif 1; other site 266264002076 active site 266264002077 motif 2; other site 266264002078 motif 3; other site 266264002079 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 266264002080 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 266264002081 putative active site [active] 266264002082 catalytic triad [active] 266264002083 putative dimer interface [polypeptide binding]; other site 266264002084 Putative Mg2+ and Co2+ transporter CorC [Inorganic ion transport and metabolism]; Region: CorC; COG4535 266264002085 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 266264002086 Transporter associated domain; Region: CorC_HlyC; smart01091 266264002087 unkown domain/putative metalloprotease fusion protein; Provisional; Region: PRK13963 266264002088 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 266264002089 PhoH-like protein; Region: PhoH; pfam02562 266264002090 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325 266264002091 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 266264002092 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 266264002093 FeS/SAM binding site; other site 266264002094 TRAM domain; Region: TRAM; pfam01938 266264002095 putative voltage-gated ClC-type chloride channel ClcB; Provisional; Region: PRK01862 266264002096 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 266264002097 Cl- selectivity filter; other site 266264002098 Cl- binding residues [ion binding]; other site 266264002099 pore gating glutamate residue; other site 266264002100 dimer interface [polypeptide binding]; other site 266264002101 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 266264002102 helicase 45; Provisional; Region: PTZ00424 266264002103 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 266264002104 ATP binding site [chemical binding]; other site 266264002105 Mg++ binding site [ion binding]; other site 266264002106 motif III; other site 266264002107 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 266264002108 nucleotide binding region [chemical binding]; other site 266264002109 ATP-binding site [chemical binding]; other site 266264002110 serine/threonine protein kinase; Provisional; Region: PRK11768 266264002111 Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334 266264002112 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 266264002113 Ligand Binding Site [chemical binding]; other site 266264002114 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 266264002115 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 266264002116 active site 266264002117 phosphorylation site [posttranslational modification] 266264002118 intermolecular recognition site; other site 266264002119 dimerization interface [polypeptide binding]; other site 266264002120 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 266264002121 DNA binding residues [nucleotide binding] 266264002122 dimerization interface [polypeptide binding]; other site 266264002123 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 266264002124 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 266264002125 catalytic residue [active] 266264002126 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 266264002127 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266264002128 putative substrate translocation pore; other site 266264002129 Domain of unknown function (DUF4212); Region: DUF4212; pfam13937 266264002130 Two-component sensor kinase N-terminal; Region: 2CSK_N; pfam08521 266264002131 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 266264002132 HAMP domain; Region: HAMP; pfam00672 266264002133 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 266264002134 dimer interface [polypeptide binding]; other site 266264002135 phosphorylation site [posttranslational modification] 266264002136 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266264002137 ATP binding site [chemical binding]; other site 266264002138 Mg2+ binding site [ion binding]; other site 266264002139 G-X-G motif; other site 266264002140 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 266264002141 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266264002142 active site 266264002143 phosphorylation site [posttranslational modification] 266264002144 intermolecular recognition site; other site 266264002145 dimerization interface [polypeptide binding]; other site 266264002146 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 266264002147 DNA binding site [nucleotide binding] 266264002148 recombinase A; Provisional; Region: recA; PRK09354 266264002149 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 266264002150 hexamer interface [polypeptide binding]; other site 266264002151 Walker A motif; other site 266264002152 ATP binding site [chemical binding]; other site 266264002153 Walker B motif; other site 266264002154 RecX family; Region: RecX; cl00936 266264002155 Protein of unknown function (DUF2889); Region: DUF2889; pfam11136 266264002156 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 266264002157 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 266264002158 CoA-ligase; Region: Ligase_CoA; pfam00549 266264002159 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 266264002160 CoA binding domain; Region: CoA_binding; smart00881 266264002161 CoA-ligase; Region: Ligase_CoA; pfam00549 266264002162 integral membrane protein, YjbE family; Region: R_switched_YjbE; TIGR03717 266264002163 Pilin (bacterial filament); Region: Pilin; pfam00114 266264002164 Pilin (bacterial filament); Region: Pilin; pfam00114 266264002165 O-Antigen ligase; Region: Wzy_C; pfam04932 266264002166 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 266264002167 Domain of unknown function (DUF3366); Region: DUF3366; pfam11846 266264002168 Glycine-zipper containing OmpA-like membrane domain; Region: Gly-zipper_OmpA; pfam13436 266264002169 MoaC family. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine derivative to the precursor...; Region: MoaC; cl00242 266264002170 ABC transporter, ATP-binding protein-related protein 266264002171 Transposase, Mutator family; Region: Transposase_mut; pfam00872 266264002172 MULE transposase domain; Region: MULE; pfam10551 266264002173 ABC transporter, ATP-binding protein-related protein 266264002174 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 266264002175 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 266264002176 Integrase core domain; Region: rve; pfam00665 266264002177 transposase/IS protein; Provisional; Region: PRK09183 266264002178 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 266264002179 Walker A motif; other site 266264002180 ATP binding site [chemical binding]; other site 266264002181 Walker B motif; other site 266264002182 arginine finger; other site 266264002183 ser/tyr recombinase family protein (fragment) 266264002184 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 266264002185 trimer interface [polypeptide binding]; other site 266264002186 dimer interface [polypeptide binding]; other site 266264002187 putative active site [active] 266264002188 Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783 266264002189 Peptidase family M48; Region: Peptidase_M48; pfam01435 266264002190 Protein of unknown function (DUF2946); Region: DUF2944; pfam11161 266264002191 Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG0429 266264002192 SnoaL-like domain; Region: SnoaL_3; pfam13474 266264002193 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 266264002194 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 266264002195 putative active site [active] 266264002196 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4391 266264002197 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 266264002198 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 266264002199 homodimer interface [polypeptide binding]; other site 266264002200 substrate-cofactor binding pocket; other site 266264002201 catalytic residue [active] 266264002202 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 266264002203 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 266264002204 ATP binding site [chemical binding]; other site 266264002205 putative Mg++ binding site [ion binding]; other site 266264002206 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 266264002207 nucleotide binding region [chemical binding]; other site 266264002208 ATP-binding site [chemical binding]; other site 266264002209 amidase; Provisional; Region: PRK06170 266264002210 Amidase; Region: Amidase; pfam01425 266264002211 benzoate transport; Region: 2A0115; TIGR00895 266264002212 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266264002213 putative substrate translocation pore; other site 266264002214 AzlC protein; Region: AzlC; pfam03591 266264002215 Branched-chain amino acid transport protein (AzlD); Region: AzlD; cl00735 266264002216 DNA-binding HTH domain-containing proteins [Transcription]; Region: CsgD; COG2771 266264002217 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 266264002218 phosphoglycerate kinase; Provisional; Region: pgk; PRK00073 266264002219 Phosphoglycerate kinase; Region: PGK; pfam00162 266264002220 substrate binding site [chemical binding]; other site 266264002221 hinge regions; other site 266264002222 ADP binding site [chemical binding]; other site 266264002223 catalytic site [active] 266264002224 pyruvate kinase; Provisional; Region: PRK05826 266264002225 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 266264002226 domain interfaces; other site 266264002227 active site 266264002228 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 266264002229 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 266264002230 intersubunit interface [polypeptide binding]; other site 266264002231 active site 266264002232 zinc binding site [ion binding]; other site 266264002233 Na+ binding site [ion binding]; other site 266264002234 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 266264002235 ATP binding site [chemical binding]; other site 266264002236 active site 266264002237 substrate binding site [chemical binding]; other site 266264002238 AIR carboxylase; Region: AIRC; pfam00731 266264002239 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 266264002240 ATP-grasp domain; Region: ATP-grasp; pfam02222 266264002241 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 266264002242 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 266264002243 D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 4) [Cell envelope biogenesis, outer membrane]; Region: DacB; COG2027 266264002244 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 266264002245 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 266264002246 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266264002247 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266264002248 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 266264002249 dimerization interface [polypeptide binding]; other site 266264002250 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 266264002251 multidrug efflux system subunit MdtC; Provisional; Region: PRK10614 266264002252 multidrug efflux system subunit MdtB; Provisional; Region: PRK10503 266264002253 Protein export membrane protein; Region: SecD_SecF; cl14618 266264002254 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 266264002255 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 266264002256 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 266264002257 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266264002258 active site 266264002259 phosphorylation site [posttranslational modification] 266264002260 intermolecular recognition site; other site 266264002261 dimerization interface [polypeptide binding]; other site 266264002262 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 266264002263 DNA binding site [nucleotide binding] 266264002264 osmolarity sensor protein; Provisional; Region: envZ; PRK09467 266264002265 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 266264002266 dimerization interface [polypeptide binding]; other site 266264002267 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 266264002268 dimer interface [polypeptide binding]; other site 266264002269 phosphorylation site [posttranslational modification] 266264002270 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266264002271 ATP binding site [chemical binding]; other site 266264002272 Mg2+ binding site [ion binding]; other site 266264002273 G-X-G motif; other site 266264002274 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 266264002275 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 266264002276 putative deacylase active site [active] 266264002277 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 266264002278 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 266264002279 active site 266264002280 Int/Topo IB signature motif; other site 266264002281 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 266264002282 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 266264002283 DNA binding site [nucleotide binding] 266264002284 active site 266264002285 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 266264002286 Chalcone-flavanone isomerase; Region: Chalcone; cl03589 266264002287 Predicted permeases [General function prediction only]; Region: COG0679 266264002288 epoxyqueuosine reductase; Region: TIGR00276 266264002289 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 266264002290 4Fe-4S binding domain; Region: Fer4; cl02805 266264002291 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 266264002292 AMIN domain; Region: AMIN; pfam11741 266264002293 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 266264002294 active site 266264002295 metal binding site [ion binding]; metal-binding site 266264002296 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 266264002297 SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593 266264002298 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266264002299 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266264002300 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 266264002301 putative dimerization interface [polypeptide binding]; other site 266264002302 Methyltransferase domain; Region: Methyltransf_31; pfam13847 266264002303 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 266264002304 S-adenosylmethionine binding site [chemical binding]; other site 266264002305 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08217 266264002306 17hydroxysteroid dehydrogenase type 10 (HSD10)-like, classical (c) SDRs; Region: HSD10-like_SDR_c; cd05371 266264002307 NAD binding site [chemical binding]; other site 266264002308 homodimer interface [polypeptide binding]; other site 266264002309 homotetramer interface [polypeptide binding]; other site 266264002310 active site 266264002311 adenylate kinase; Reviewed; Region: adk; PRK00279 266264002312 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 266264002313 AMP-binding site [chemical binding]; other site 266264002314 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 266264002315 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 266264002316 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 266264002317 Ligand binding site; other site 266264002318 oligomer interface; other site 266264002319 Uncharacterized conserved protein [Function unknown]; Region: COG2835 266264002320 tetraacyldisaccharide 4'-kinase; Provisional; Region: PRK01906 266264002321 Tetraacyldisaccharide-1-P 4'-kinase; Region: LpxK; pfam02606 266264002322 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 266264002323 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 266264002324 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 266264002325 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 266264002326 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 266264002327 generic binding surface II; other site 266264002328 generic binding surface I; other site 266264002329 superoxide dismutase; Provisional; Region: PRK10543 266264002330 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 266264002331 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 266264002332 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 266264002333 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 266264002334 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266264002335 D-galactonate transporter; Region: 2A0114; TIGR00893 266264002336 putative substrate translocation pore; other site 266264002337 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 266264002338 dinuclear metal binding motif [ion binding]; other site 266264002339 phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160 266264002340 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214 266264002341 FAD binding pocket [chemical binding]; other site 266264002342 FAD binding motif [chemical binding]; other site 266264002343 phosphate binding motif [ion binding]; other site 266264002344 beta-alpha-beta structure motif; other site 266264002345 NAD(p) ribose binding residues [chemical binding]; other site 266264002346 NAD binding pocket [chemical binding]; other site 266264002347 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site 266264002348 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 266264002349 catalytic loop [active] 266264002350 iron binding site [ion binding]; other site 266264002351 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 266264002352 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 266264002353 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 266264002354 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 266264002355 NAD binding site [chemical binding]; other site 266264002356 catalytic Zn binding site [ion binding]; other site 266264002357 substrate binding site [chemical binding]; other site 266264002358 structural Zn binding site [ion binding]; other site 266264002359 3-hydroxybutyrate dehydrogenase; Provisional; Region: PRK12429 266264002360 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266264002361 NAD(P) binding site [chemical binding]; other site 266264002362 active site 266264002363 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 266264002364 PAS fold; Region: PAS_4; pfam08448 266264002365 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 266264002366 putative active site [active] 266264002367 heme pocket [chemical binding]; other site 266264002368 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 266264002369 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 266264002370 Walker A motif; other site 266264002371 ATP binding site [chemical binding]; other site 266264002372 Walker B motif; other site 266264002373 arginine finger; other site 266264002374 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 266264002375 Uncharacterized bacterial subgroup of the Salmonella typhimurium Zn2+ transporter ZntB-like subfamily; Region: ZntB_u1; cd12834 266264002376 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 266264002377 Cl binding site [ion binding]; other site 266264002378 oligomer interface [polypeptide binding]; other site 266264002379 polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707 266264002380 Peptidase M30; Region: Peptidase_M30; pfam10460 266264002381 N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; cl17549 266264002382 PBP superfamily domain; Region: PBP_like; pfam12727 266264002383 Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257 266264002384 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily, NAD-dependent formate dehydrogenase (FDH) gamma subunit; composed of proteins similar to the gamma subunit of NAD-linked FDH of Ralstonia eutropha, a...; Region: TRX_Fd_NuoE_FDH_gamma; cd03081 266264002385 putative dimer interface [polypeptide binding]; other site 266264002386 [2Fe-2S] cluster binding site [ion binding]; other site 266264002387 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NAD-dependent formate dehydrogenase (FDH) beta subunit; composed of proteins similar to the beta subunit of NAD-linked FDH of Ralstonia eutropha, a soluble enzyme that catalyzes the irreversible oxidation of...; Region: TRX_Fd_FDH_beta; cd03063 266264002388 putative dimer interface [polypeptide binding]; other site 266264002389 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 266264002390 SLBB domain; Region: SLBB; pfam10531 266264002391 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928 266264002392 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 266264002393 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 266264002394 catalytic loop [active] 266264002395 iron binding site [ion binding]; other site 266264002396 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 266264002397 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 266264002398 [4Fe-4S] binding site [ion binding]; other site 266264002399 molybdopterin cofactor binding site; other site 266264002400 This CD includes formate dehydrogenases (Fdh) H and N; nitrate reductases, Nap and Nas; and other related proteins. Formate dehydrogenase H is a component of the anaerobic formate hydrogen lyase complex and catalyzes the reversible oxidation of formate...; Region: MopB_CT_Fdh-Nap-like; cd00508 266264002401 molybdopterin cofactor binding site; other site 266264002402 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 266264002403 NADH-dependant formate dehydrogenase delta subunit FdsD; Region: FdsD; pfam11390 266264002404 Transglycosylase; Region: Transgly; pfam00912 266264002405 Malate/L-lactate dehydrogenase; Region: Ldh_2; cl00900 266264002406 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 266264002407 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 266264002408 transmembrane helices; other site 266264002409 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 266264002410 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 266264002411 propionate/acetate kinase; Provisional; Region: PRK12379 266264002412 Acetokinase family; Region: Acetate_kinase; cl17229 266264002413 phosphate acetyltransferase; Provisional; Region: PRK11890 266264002414 bifunctional enoyl-CoA hydratase/phosphate acetyltransferase; Validated; Region: PRK08190 266264002415 Protein of unknown function (DUF3141); Region: DUF3141; pfam11339 266264002416 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 266264002417 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK07533 266264002418 NAD binding site [chemical binding]; other site 266264002419 homotetramer interface [polypeptide binding]; other site 266264002420 homodimer interface [polypeptide binding]; other site 266264002421 substrate binding site [chemical binding]; other site 266264002422 active site 266264002423 RNA recognition motif (RRM) superfamily; Region: RRM_SF; cd00590 266264002424 N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; COG2005 266264002425 DNA-binding transcriptional regulator ModE; Provisional; Region: PRK10676 266264002426 TOBE domain; Region: TOBE; cl01440 266264002427 Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585 266264002428 Adenylyl cyclase (AC) class IV-like, a subgroup of the CYTH-like superfamily; Region: CYTH-like_AC_IV-like; cd07890 266264002429 putative active site [active] 266264002430 putative metal binding residues [ion binding]; other site 266264002431 signature motif; other site 266264002432 putative triphosphate binding site [ion binding]; other site 266264002433 dimer interface [polypeptide binding]; other site 266264002434 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 266264002435 ABC exporter ATP-binding subunit, DevA family; Region: heterocyst_DevA; TIGR02982 266264002436 Walker A/P-loop; other site 266264002437 ATP binding site [chemical binding]; other site 266264002438 Q-loop/lid; other site 266264002439 ABC transporter signature motif; other site 266264002440 Walker B; other site 266264002441 D-loop; other site 266264002442 H-loop/switch region; other site 266264002443 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 266264002444 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266264002445 dimer interface [polypeptide binding]; other site 266264002446 conserved gate region; other site 266264002447 putative PBP binding loops; other site 266264002448 ABC-ATPase subunit interface; other site 266264002449 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 266264002450 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 266264002451 2',3'-cyclic-nucleotide 2'-phosphodiesterase; Region: CycNucDiestase; TIGR01390 266264002452 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 266264002453 active site 266264002454 metal binding site [ion binding]; metal-binding site 266264002455 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 266264002456 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 266264002457 Sel1-like repeats; Region: SEL1; smart00671 266264002458 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 266264002459 PapC N-terminal domain; Region: PapC_N; pfam13954 266264002460 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 266264002461 PapC C-terminal domain; Region: PapC_C; pfam13953 266264002462 fimbrial chaperone protein StiB; Provisional; Region: PRK15299 266264002463 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 266264002464 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 266264002465 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 266264002466 Nucleoside 2-deoxyribosyltransferase [Nucleotide transport and metabolism]; Region: COG3613 266264002467 Protein of unknown function (DUF330); Region: DUF330; pfam03886 266264002468 Paraquat-inducible protein B [General function prediction only]; Region: PqiB; COG3008 266264002469 mce related protein; Region: MCE; pfam02470 266264002470 mce related protein; Region: MCE; pfam02470 266264002471 Uncharacterized paraquat-inducible protein A [Function unknown]; Region: PqiA; COG2995 266264002472 Paraquat-inducible protein A; Region: PqiA; pfam04403 266264002473 Paraquat-inducible protein A; Region: PqiA; pfam04403 266264002474 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 266264002475 Domain of unknown function DUF20; Region: UPF0118; pfam01594 266264002476 CBS-domain-containing membrane protein [Signal transduction mechanisms]; Region: COG3448 266264002477 HPP family; Region: HPP; pfam04982 266264002478 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the HPP motif domain. These proteins are integral membrane proteins with four transmembrane spanning helices. The function of these proteins is...; Region: CBS_pair_HPP_assoc; cd04600 266264002479 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 266264002480 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 266264002481 Cl- selectivity filter; other site 266264002482 Cl- binding residues [ion binding]; other site 266264002483 pore gating glutamate residue; other site 266264002484 dimer interface [polypeptide binding]; other site 266264002485 FOG: CBS domain [General function prediction only]; Region: COG0517 266264002486 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with either the SpoIVFB domain (sporulation protein, stage IV cell wall formation, F locus, promoter-distal B) or the chloride channel protein EriC; Region: CBS_pair_SpoIVFB_EriC_assoc; cd04612 266264002487 N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834 266264002488 Amidinotransferase; Region: Amidinotransf; pfam02274 266264002489 ornithine cyclodeaminase; Validated; Region: PRK07589 266264002490 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 266264002491 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 266264002492 DNA binding residues [nucleotide binding] 266264002493 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 266264002494 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266264002495 active site 266264002496 phosphorylation site [posttranslational modification] 266264002497 intermolecular recognition site; other site 266264002498 dimerization interface [polypeptide binding]; other site 266264002499 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 266264002500 Walker A motif; other site 266264002501 ATP binding site [chemical binding]; other site 266264002502 Walker B motif; other site 266264002503 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 266264002504 Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191 266264002505 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 266264002506 dimer interface [polypeptide binding]; other site 266264002507 phosphorylation site [posttranslational modification] 266264002508 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266264002509 ATP binding site [chemical binding]; other site 266264002510 Mg2+ binding site [ion binding]; other site 266264002511 G-X-G motif; other site 266264002512 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 266264002513 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 266264002514 MASE1; Region: MASE1; cl17823 266264002515 putative diguanylate cyclase; Provisional; Region: PRK09776 266264002516 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 266264002517 putative active site [active] 266264002518 heme pocket [chemical binding]; other site 266264002519 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 266264002520 heme pocket [chemical binding]; other site 266264002521 putative active site [active] 266264002522 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 266264002523 putative active site [active] 266264002524 heme pocket [chemical binding]; other site 266264002525 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 266264002526 metal binding site [ion binding]; metal-binding site 266264002527 active site 266264002528 I-site; other site 266264002529 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 266264002530 SnoaL-like domain; Region: SnoaL_2; pfam12680 266264002531 Cytochrome c; Region: Cytochrom_C; pfam00034 266264002532 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 266264002533 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 266264002534 catalytic loop [active] 266264002535 iron binding site [ion binding]; other site 266264002536 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 266264002537 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 266264002538 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 266264002539 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 266264002540 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 266264002541 Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662 266264002542 mycothiol system anti-sigma-R factor; Region: antisig_RsrA; cl15806 266264002543 RNA polymerase sigma factor; Provisional; Region: PRK12533 266264002544 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 266264002545 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 266264002546 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 266264002547 active site 266264002548 metal binding site [ion binding]; metal-binding site 266264002549 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 266264002550 multidrug efflux system subunit MdtB; Provisional; Region: PRK10503 266264002551 Protein export membrane protein; Region: SecD_SecF; cl14618 266264002552 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 266264002553 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 266264002554 HlyD family secretion protein; Region: HlyD_3; pfam13437 266264002555 MASE1; Region: MASE1; cl17823 266264002556 PAS fold; Region: PAS_3; pfam08447 266264002557 Esterase/lipase [General function prediction only]; Region: COG1647 266264002558 SnoaL-like domain; Region: SnoaL_2; pfam12680 266264002559 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 266264002560 Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205 266264002561 active site 266264002562 nucleophile elbow; other site 266264002563 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 266264002564 Surface antigen; Region: Bac_surface_Ag; pfam01103 266264002565 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 266264002566 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 266264002567 Sulfate transporter family; Region: Sulfate_transp; pfam00916 266264002568 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 266264002569 Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119 266264002570 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 266264002571 active site 266264002572 catalytic residues [active] 266264002573 metal binding site [ion binding]; metal-binding site 266264002574 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 266264002575 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 266264002576 ATP-grasp domain; Region: ATP-grasp_4; cl17255 266264002577 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 266264002578 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 266264002579 carboxyltransferase (CT) interaction site; other site 266264002580 biotinylation site [posttranslational modification]; other site 266264002581 3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820 266264002582 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 266264002583 AMP-binding domain protein; Validated; Region: PRK08315 266264002584 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 266264002585 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 266264002586 acyl-activating enzyme (AAE) consensus motif; other site 266264002587 putative AMP binding site [chemical binding]; other site 266264002588 putative active site [active] 266264002589 putative CoA binding site [chemical binding]; other site 266264002590 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 266264002591 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 266264002592 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 266264002593 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266264002594 active site 266264002595 phosphorylation site [posttranslational modification] 266264002596 intermolecular recognition site; other site 266264002597 dimerization interface [polypeptide binding]; other site 266264002598 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 266264002599 DNA binding residues [nucleotide binding] 266264002600 dimerization interface [polypeptide binding]; other site 266264002601 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 266264002602 Histidine kinase; Region: HisKA_3; pfam07730 266264002603 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266264002604 ATP binding site [chemical binding]; other site 266264002605 Mg2+ binding site [ion binding]; other site 266264002606 G-X-G motif; other site 266264002607 Extended Signal Peptide of Type V secretion system; Region: ESPR; pfam13018 266264002608 haemagglutination activity domain; Region: Haemagg_act; smart00912 266264002609 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344 266264002610 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 266264002611 Autotransporter beta-domain; Region: Autotransporter; pfam03797 266264002612 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 266264002613 oligomerisation interface [polypeptide binding]; other site 266264002614 mobile loop; other site 266264002615 roof hairpin; other site 266264002616 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 266264002617 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 266264002618 ring oligomerisation interface [polypeptide binding]; other site 266264002619 ATP/Mg binding site [chemical binding]; other site 266264002620 stacking interactions; other site 266264002621 hinge regions; other site 266264002622 type VI secretion system lysozyme-like protein; Region: VI_zyme; TIGR03357 266264002623 type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345 266264002624 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 266264002625 Walker A motif; other site 266264002626 ATP binding site [chemical binding]; other site 266264002627 Walker B motif; other site 266264002628 arginine finger; other site 266264002629 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 266264002630 Walker A motif; other site 266264002631 ATP binding site [chemical binding]; other site 266264002632 Walker B motif; other site 266264002633 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 266264002634 type VI secretion system effector, Hcp1 family; Region: VI_effect_Hcp1; TIGR03344 266264002635 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 266264002636 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 266264002637 ligand binding site [chemical binding]; other site 266264002638 type IV / VI secretion system protein, DotU family; Region: IV_VI_DotU; TIGR03349 266264002639 Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936 266264002640 type VI secretion protein, VC_A0114 family; Region: VI_chp_4; TIGR03353 266264002641 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3522; cl01406 266264002642 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3517; cl05484 266264002643 Protein of unknown function (DUF877); Region: DUF877; pfam05943 266264002644 Protein of unknown function (DUF770); Region: DUF770; pfam05591 266264002645 Rhs element Vgr protein; Region: vgr_GE; TIGR01646 266264002646 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 266264002647 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 266264002648 Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296 266264002649 Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; pfam10106 266264002650 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 266264002651 Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502 266264002652 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 266264002653 putative active site [active] 266264002654 catalytic site [active] 266264002655 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 266264002656 Catalytic domain, repeat 2, of vertebrate phospholipases, PLD1 and PLD2, and similar proteins; Region: PLDc_vPLD1_2_like_2; cd09105 266264002657 putative active site [active] 266264002658 catalytic site [active] 266264002659 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 266264002660 Sel1-like repeats; Region: SEL1; smart00671 266264002661 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 266264002662 Sel1-like repeats; Region: SEL1; smart00671 266264002663 PAAR motif; Region: PAAR_motif; pfam05488 266264002664 Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761 266264002665 Protein of unknown function (DUF1215); Region: DUF1215; pfam06744 266264002666 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 266264002667 type VI secretion-associated protein, VC_A0119 family; Region: VI_chp_7; TIGR03362 266264002668 Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3519 266264002669 Bacterial protein of unknown function (DUF879); Region: DUF879; pfam05947 266264002670 Protein of unknown function (DUF1305); Region: DUF1305; pfam06996 266264002671 Type VI secretion lipoprotein; Region: T6SS-SciN; pfam12790 266264002672 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 266264002673 Microscilla MS158 and related proteins, metallophosphatase domain; Region: MPP_MS158; cd07404 266264002674 putative active site [active] 266264002675 putative metal binding site [ion binding]; other site 266264002676 Flp pilus assembly protein TadC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: TadC; COG2064 266264002677 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 266264002678 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 266264002679 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 266264002680 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 266264002681 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 266264002682 ATP binding site [chemical binding]; other site 266264002683 Walker A motif; other site 266264002684 hexamer interface [polypeptide binding]; other site 266264002685 Walker B motif; other site 266264002686 Flp pilus assembly protein, ATPase CpaE [Intracellular trafficking and secretion]; Region: CpaE; COG4963 266264002687 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266264002688 active site 266264002689 phosphorylation site [posttranslational modification] 266264002690 dimerization interface [polypeptide binding]; other site 266264002691 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 266264002692 Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961 266264002693 TadE-like protein; Region: TadE; pfam07811 266264002694 Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961 266264002695 TadE-like protein; Region: TadE; pfam07811 266264002696 Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961 266264002697 Putative Flp pilus-assembly TadE/G-like; Region: Tad; pfam13400 266264002698 Flp pilus assembly protein, secretin CpaC [Intracellular trafficking and secretion]; Region: CpaC; COG4964 266264002699 Pilus formation protein N terminal region; Region: T2SS-T3SS_pil_N; pfam13629 266264002700 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 266264002701 Flp pilus assembly protein CpaB [Intracellular trafficking and secretion]; Region: CpaB; COG3745 266264002702 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 266264002703 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 266264002704 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 266264002705 Walker A motif; other site 266264002706 ATP binding site [chemical binding]; other site 266264002707 Walker B motif; other site 266264002708 arginine finger; other site 266264002709 Flp pilus assembly protein, protease CpaA [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: CpaA; COG4960 266264002710 Flp/Fap pilin component; Region: Flp_Fap; pfam04964 266264002711 Flp/Fap pilin component; Region: Flp_Fap; cl01585 266264002712 Flp/Fap pilin component; Region: Flp_Fap; cl01585 266264002713 Protein of unknown function (DUF2029); Region: DUF2029; pfam09594 266264002714 Protein of unknown function (DUF2029); Region: DUF2029; pfam09594 266264002715 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 266264002716 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 266264002717 Ligand binding site; other site 266264002718 Putative Catalytic site; other site 266264002719 DXD motif; other site 266264002720 Protein of unknown function (DUF2029); Region: DUF2029; pfam09594 266264002721 Predicted membrane protein [Function unknown]; Region: COG2246 266264002722 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 266264002723 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 266264002724 Walker A motif; other site 266264002725 ATP binding site [chemical binding]; other site 266264002726 Walker B motif; other site 266264002727 arginine finger; other site 266264002728 Phage antirepressor protein KilAC domain; Region: ANT; cl01462 266264002729 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266264002730 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 266264002731 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 266264002732 dimerization interface [polypeptide binding]; other site 266264002733 substrate binding pocket [chemical binding]; other site 266264002734 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266264002735 Major Facilitator Superfamily; Region: MFS_1; pfam07690 266264002736 putative substrate translocation pore; other site 266264002737 MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300 266264002738 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 266264002739 Repair protein; Region: Repair_PSII; cl01535 266264002740 Beta-propeller domains of methanol dehydrogenase type [General function prediction only]; Region: COG1512 266264002741 Repair protein; Region: Repair_PSII; pfam04536 266264002742 Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704 266264002743 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 266264002744 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 266264002745 dimer interface [polypeptide binding]; other site 266264002746 active site 266264002747 catalytic residue [active] 266264002748 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 266264002749 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 266264002750 inhibitor-cofactor binding pocket; inhibition site 266264002751 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266264002752 catalytic residue [active] 266264002753 Rubredoxin [Energy production and conversion]; Region: COG1773 266264002754 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 266264002755 iron binding site [ion binding]; other site 266264002756 Response regulator receiver domain; Region: Response_reg; pfam00072 266264002757 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266264002758 active site 266264002759 phosphorylation site [posttranslational modification] 266264002760 intermolecular recognition site; other site 266264002761 dimerization interface [polypeptide binding]; other site 266264002762 Response regulator receiver domain; Region: Response_reg; pfam00072 266264002763 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266264002764 active site 266264002765 phosphorylation site [posttranslational modification] 266264002766 intermolecular recognition site; other site 266264002767 dimerization interface [polypeptide binding]; other site 266264002768 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cd00588 266264002769 Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675 266264002770 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 266264002771 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 266264002772 dimer interface [polypeptide binding]; other site 266264002773 putative CheW interface [polypeptide binding]; other site 266264002774 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 266264002775 putative binding surface; other site 266264002776 active site 266264002777 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 266264002778 putative binding surface; other site 266264002779 active site 266264002780 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 266264002781 putative binding surface; other site 266264002782 active site 266264002783 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 266264002784 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266264002785 ATP binding site [chemical binding]; other site 266264002786 Mg2+ binding site [ion binding]; other site 266264002787 G-X-G motif; other site 266264002788 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 266264002789 Response regulator receiver domain; Region: Response_reg; pfam00072 266264002790 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266264002791 active site 266264002792 phosphorylation site [posttranslational modification] 266264002793 intermolecular recognition site; other site 266264002794 dimerization interface [polypeptide binding]; other site 266264002795 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266264002796 D-galactonate transporter; Region: 2A0114; TIGR00893 266264002797 putative substrate translocation pore; other site 266264002798 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR), subgroup 3, classical (c) SDR; Region: BKR_3_SDR_c; cd05345 266264002799 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 266264002800 putative NAD(P) binding site [chemical binding]; other site 266264002801 active site 266264002802 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 266264002803 Uncharacterized Saccharopolyspora spinosa aldehyde dehydrogenase (AAS00426)-like; Region: ALDH_AAS00426; cd07109 266264002804 NAD(P) binding site [chemical binding]; other site 266264002805 catalytic residues [active] 266264002806 catalytic residues [active] 266264002807 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 266264002808 dimer interface [polypeptide binding]; other site 266264002809 substrate binding site [chemical binding]; other site 266264002810 metal binding sites [ion binding]; metal-binding site 266264002811 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; cl17497 266264002812 Protein of unknown function, DUF482; Region: DUF482; pfam04339 266264002813 NAD synthetase; Reviewed; Region: nadE; PRK02628 266264002814 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 266264002815 multimer interface [polypeptide binding]; other site 266264002816 active site 266264002817 catalytic triad [active] 266264002818 protein interface 1 [polypeptide binding]; other site 266264002819 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 266264002820 homodimer interface [polypeptide binding]; other site 266264002821 NAD binding pocket [chemical binding]; other site 266264002822 ATP binding pocket [chemical binding]; other site 266264002823 Mg binding site [ion binding]; other site 266264002824 active-site loop [active] 266264002825 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 266264002826 Nitrogen regulatory protein P-II; Region: P-II; smart00938 266264002827 Predicted membrane protein [Function unknown]; Region: COG2860 266264002828 UPF0126 domain; Region: UPF0126; pfam03458 266264002829 UPF0126 domain; Region: UPF0126; pfam03458 266264002830 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840 266264002831 Smr domain; Region: Smr; pfam01713 266264002832 thioredoxin reductase; Provisional; Region: PRK10262 266264002833 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 266264002834 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 266264002835 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 266264002836 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 266264002837 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 266264002838 lipoprotein chaperone; Reviewed; Region: lolA; PRK00031 266264002839 Outer membrane lipoprotein carrier protein LolA; Region: LolA; pfam03548 266264002840 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 266264002841 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 266264002842 substrate binding pocket [chemical binding]; other site 266264002843 membrane-bound complex binding site; other site 266264002844 hinge residues; other site 266264002845 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 266264002846 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266264002847 dimer interface [polypeptide binding]; other site 266264002848 conserved gate region; other site 266264002849 putative PBP binding loops; other site 266264002850 ABC-ATPase subunit interface; other site 266264002851 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266264002852 dimer interface [polypeptide binding]; other site 266264002853 conserved gate region; other site 266264002854 putative PBP binding loops; other site 266264002855 ABC-ATPase subunit interface; other site 266264002856 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 266264002857 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 266264002858 Walker A/P-loop; other site 266264002859 ATP binding site [chemical binding]; other site 266264002860 Q-loop/lid; other site 266264002861 ABC transporter signature motif; other site 266264002862 Walker B; other site 266264002863 D-loop; other site 266264002864 H-loop/switch region; other site 266264002865 recombination factor protein RarA; Reviewed; Region: PRK13342 266264002866 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 266264002867 Walker A motif; other site 266264002868 ATP binding site [chemical binding]; other site 266264002869 Walker B motif; other site 266264002870 arginine finger; other site 266264002871 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 266264002872 seryl-tRNA synthetase; Provisional; Region: PRK05431 266264002873 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 266264002874 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 266264002875 dimer interface [polypeptide binding]; other site 266264002876 active site 266264002877 motif 1; other site 266264002878 motif 2; other site 266264002879 motif 3; other site 266264002880 serine-based site-specific recombinase (fragment) 266264002881 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830 266264002882 Pilin (bacterial filament); Region: Pilin; pfam00114 266264002883 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 266264002884 Domain of unknown function DUF21; Region: DUF21; pfam01595 266264002885 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 266264002886 Transporter associated domain; Region: CorC_HlyC; smart01091 266264002887 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266264002888 The C-terminal substrate-domain of LysR-type transcriptional regulators involved in the catabolism of opines and that of related regulators, contains the type 2 periplasmic binding fold; Region: PBP2_LysR_opines_like; cd08415 266264002889 putative dimerization interface [polypeptide binding]; other site 266264002890 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 266264002891 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 266264002892 hydroxyglutarate oxidase; Provisional; Region: PRK11728 266264002893 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 266264002894 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 266264002895 substrate binding pocket [chemical binding]; other site 266264002896 membrane-bound complex binding site; other site 266264002897 hinge residues; other site 266264002898 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; some contain an N-terminal GntR family winged HTH DNA-binding domain; Region: SRPBCC_CalC_Aha1-like_GntR-HTH; cd08893 266264002899 putative hydrophobic ligand binding site [chemical binding]; other site 266264002900 cyanophycin synthetase; Provisional; Region: PRK14016 266264002901 ATP-grasp domain; Region: ATP-grasp_4; cl17255 266264002902 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 266264002903 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 266264002904 cyanophycin synthetase; Provisional; Region: PRK14016 266264002905 ATP-grasp domain; Region: ATP-grasp_4; cl17255 266264002906 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 266264002907 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 266264002908 ABC transporter, permease/ATP-binding protein; Region: MsbA_rel; TIGR02204 266264002909 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 266264002910 ATP-binding cassette domain of a mitochondrial protein MTABC3 and related proteins; Region: ABC_MTABC3_MDL1_MDL2; cd03249 266264002911 Walker A/P-loop; other site 266264002912 ATP binding site [chemical binding]; other site 266264002913 Q-loop/lid; other site 266264002914 ABC transporter signature motif; other site 266264002915 Walker B; other site 266264002916 D-loop; other site 266264002917 H-loop/switch region; other site 266264002918 Domain of unknown function (DUF1854); Region: DUF1854; pfam08909 266264002919 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 266264002920 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 266264002921 motif II; other site 266264002922 bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134 266264002923 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 266264002924 S-adenosylmethionine binding site [chemical binding]; other site 266264002925 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 266264002926 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 266264002927 ligand binding site [chemical binding]; other site 266264002928 DNA gyrase subunit A; Validated; Region: PRK05560 266264002929 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 266264002930 CAP-like domain; other site 266264002931 active site 266264002932 primary dimer interface [polypeptide binding]; other site 266264002933 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 266264002934 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 266264002935 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 266264002936 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 266264002937 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 266264002938 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 266264002939 Uncharacterized protein conserved in bacteria (DUF2059); Region: DUF2059; pfam09832 266264002940 Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active as...; Region: PSAT_like; cd00611 266264002941 homodimer interface [polypeptide binding]; other site 266264002942 substrate-cofactor binding pocket; other site 266264002943 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266264002944 catalytic residue [active] 266264002945 Chorismate mutase type II; Region: CM_2; cl00693 266264002946 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 266264002947 Prephenate dehydratase; Region: PDT; pfam00800 266264002948 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 266264002949 putative L-Phe binding site [chemical binding]; other site 266264002950 histidinol-phosphate aminotransferase; Validated; Region: PRK02731 266264002951 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 266264002952 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266264002953 homodimer interface [polypeptide binding]; other site 266264002954 catalytic residue [active] 266264002955 prephenate dehydrogenase; Validated; Region: PRK08507 266264002956 Prephenate dehydrogenase; Region: PDH; pfam02153 266264002957 3-phosphoshikimate 1-carboxyvinyltransferase; Region: PLN02338 266264002958 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 266264002959 hinge; other site 266264002960 active site 266264002961 Predicted membrane protein (DUF2061); Region: DUF2061; pfam09834 266264002962 cytidylate kinase; Provisional; Region: cmk; PRK00023 266264002963 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 266264002964 CMP-binding site; other site 266264002965 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 266264002966 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 266264002967 RNA binding site [nucleotide binding]; other site 266264002968 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 266264002969 RNA binding site [nucleotide binding]; other site 266264002970 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 266264002971 RNA binding site [nucleotide binding]; other site 266264002972 S1_RPS1_repeat_ec4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec4; cd05689 266264002973 RNA binding site [nucleotide binding]; other site 266264002974 S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec5; cd05690 266264002975 RNA binding site [nucleotide binding]; other site 266264002976 S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691 266264002977 RNA binding site [nucleotide binding]; other site 266264002978 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 266264002979 IHF dimer interface [polypeptide binding]; other site 266264002980 IHF - DNA interface [nucleotide binding]; other site 266264002981 tetratricopeptide repeat protein; Provisional; Region: PRK11788 266264002982 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 266264002983 binding surface 266264002984 TPR motif; other site 266264002985 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 266264002986 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 266264002987 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 266264002988 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 266264002989 RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172 266264002990 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 266264002991 putative ribose interaction site [chemical binding]; other site 266264002992 putative ADP binding site [chemical binding]; other site 266264002993 ADP-L-glycero-D-mannoheptose 6-epimerase (GME), extended (e) SDRs; Region: ADP_GME_SDR_e; cd05248 266264002994 ADP-L-glycero-D-manno-heptose-6-epimerase; Region: heptose_epim; TIGR02197 266264002995 NADP binding site [chemical binding]; other site 266264002996 homopentamer interface [polypeptide binding]; other site 266264002997 substrate binding site [chemical binding]; other site 266264002998 active site 266264002999 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 266264003000 uracil-xanthine permease; Region: ncs2; TIGR00801 266264003001 cysteine synthase B; Region: cysM; TIGR01138 266264003002 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 266264003003 dimer interface [polypeptide binding]; other site 266264003004 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266264003005 catalytic residue [active] 266264003006 Transglycosylase SLT domain; Region: SLT_2; pfam13406 266264003007 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 266264003008 N-acetyl-D-glucosamine binding site [chemical binding]; other site 266264003009 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 266264003010 Histone deacetylases and histone-like deacetylases, classII; Region: HDAC_classII_2; cd11599 266264003011 putative active site [active] 266264003012 Zn binding site [ion binding]; other site 266264003013 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 266264003014 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 266264003015 Walker A/P-loop; other site 266264003016 ATP binding site [chemical binding]; other site 266264003017 Q-loop/lid; other site 266264003018 ABC transporter signature motif; other site 266264003019 Walker B; other site 266264003020 D-loop; other site 266264003021 H-loop/switch region; other site 266264003022 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 266264003023 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266264003024 ABC-ATPase subunit interface; other site 266264003025 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 266264003026 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 266264003027 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 266264003028 Ligand binding site [chemical binding]; other site 266264003029 Electron transfer flavoprotein domain; Region: ETF; pfam01012 266264003030 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 266264003031 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 266264003032 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 266264003033 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 266264003034 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 266264003035 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 266264003036 active site 266264003037 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 266264003038 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 266264003039 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 266264003040 leucine-responsive transcriptional regulator; Provisional; Region: PRK11169 266264003041 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 266264003042 putative DNA binding site [nucleotide binding]; other site 266264003043 putative Zn2+ binding site [ion binding]; other site 266264003044 AsnC family; Region: AsnC_trans_reg; pfam01037 266264003045 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 266264003046 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 266264003047 FeS/SAM binding site; other site 266264003048 transcriptional activator TtdR; Provisional; Region: PRK09801 266264003049 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 266264003050 putative effector binding pocket; other site 266264003051 dimerization interface [polypeptide binding]; other site 266264003052 TM2 domain; Region: TM2; pfam05154 266264003053 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 266264003054 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 266264003055 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 266264003056 RimM N-terminal domain; Region: RimM; pfam01782 266264003057 PRC-barrel domain; Region: PRC; pfam05239 266264003058 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 266264003059 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 266264003060 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 266264003061 putative active site [active] 266264003062 putative CoA binding site [chemical binding]; other site 266264003063 nudix motif; other site 266264003064 metal binding site [ion binding]; metal-binding site 266264003065 rhodanese superfamily protein; Provisional; Region: PRK05320 266264003066 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 266264003067 active site residue [active] 266264003068 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 266264003069 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433 266264003070 putative active site [active] 266264003071 putative PHP Thumb interface [polypeptide binding]; other site 266264003072 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 266264003073 generic binding surface II; other site 266264003074 generic binding surface I; other site 266264003075 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 266264003076 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 266264003077 putative ADP-binding pocket [chemical binding]; other site 266264003078 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 266264003079 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 266264003080 putative metal binding site; other site 266264003081 lipid A export permease/ATP-binding protein MsbA; Region: MsbA_lipidA; TIGR02203 266264003082 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 266264003083 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 266264003084 Walker A/P-loop; other site 266264003085 ATP binding site [chemical binding]; other site 266264003086 Q-loop/lid; other site 266264003087 ABC transporter signature motif; other site 266264003088 Walker B; other site 266264003089 D-loop; other site 266264003090 H-loop/switch region; other site 266264003091 uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926 266264003092 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 266264003093 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 266264003094 phosphonate metabolism protein PhnM; Provisional; Region: PRK15446 266264003095 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 266264003096 active site 266264003097 ABC-type phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PhnL; COG4778 266264003098 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 266264003099 Walker A/P-loop; other site 266264003100 ATP binding site [chemical binding]; other site 266264003101 Q-loop/lid; other site 266264003102 ABC transporter signature motif; other site 266264003103 Walker B; other site 266264003104 D-loop; other site 266264003105 H-loop/switch region; other site 266264003106 phosphonate C-P lyase system protein PhnK; Provisional; Region: phnK; PRK11701 266264003107 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 266264003108 Walker A/P-loop; other site 266264003109 ATP binding site [chemical binding]; other site 266264003110 Q-loop/lid; other site 266264003111 ABC transporter signature motif; other site 266264003112 Walker B; other site 266264003113 D-loop; other site 266264003114 H-loop/switch region; other site 266264003115 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 266264003116 Phosphonate metabolism protein PhnJ; Region: PhnJ; pfam06007 266264003117 Bacterial phosphonate metabolism protein (PhnI); Region: PhnI; pfam05861 266264003118 carbon-phosphorus lyase complex subunit; Validated; Region: phnH; PRK10147 266264003119 Phosphonate metabolism protein PhnG; Region: PhnG; pfam06754 266264003120 phosphonates metabolism transcriptional regulator PhnF; Region: C_P_lyase_phnF; TIGR02325 266264003121 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266264003122 DNA-binding site [nucleotide binding]; DNA binding site 266264003123 UTRA domain; Region: UTRA; pfam07702 266264003124 phosphonate metabolism protein PhnM; Provisional; Region: PRK15446 266264003125 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 266264003126 PhnM is believed to be a subunit of the membrane associated C-P lyase complex. C-P lyase is thought to catalyze the direct cleavage of inactivated C-P bonds to yield inorganic phosphate and the corresponding hydrocarbons. It is responsible for cleavage...; Region: PhnM; cd01306 266264003127 active site 266264003128 putative phosphonate metabolism protein; Region: Phn_opern_protn; TIGR03223 266264003129 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 266264003130 Guanylate kinase; Region: Guanylate_kin; pfam00625 266264003131 active site 266264003132 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 266264003133 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 266264003134 Zn2+ binding site [ion binding]; other site 266264003135 Mg2+ binding site [ion binding]; other site 266264003136 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 266264003137 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266264003138 dimer interface [polypeptide binding]; other site 266264003139 conserved gate region; other site 266264003140 putative PBP binding loops; other site 266264003141 ABC-ATPase subunit interface; other site 266264003142 phosphonate ABC transporter, periplasmic phosphonate binding protein; Region: PhnD; TIGR03431 266264003143 ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638 266264003144 ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256 266264003145 Walker A/P-loop; other site 266264003146 ATP binding site [chemical binding]; other site 266264003147 Q-loop/lid; other site 266264003148 ABC transporter signature motif; other site 266264003149 Walker B; other site 266264003150 D-loop; other site 266264003151 H-loop/switch region; other site 266264003152 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266264003153 D-galactonate transporter; Region: 2A0114; TIGR00893 266264003154 putative substrate translocation pore; other site 266264003155 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266264003156 Major Facilitator Superfamily; Region: MFS_1; pfam07690 266264003157 putative substrate translocation pore; other site 266264003158 ribonuclease G; Provisional; Region: PRK11712 266264003159 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 266264003160 homodimer interface [polypeptide binding]; other site 266264003161 oligonucleotide binding site [chemical binding]; other site 266264003162 Maf-like protein; Region: Maf; pfam02545 266264003163 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 266264003164 active site 266264003165 dimer interface [polypeptide binding]; other site 266264003166 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 266264003167 iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090 266264003168 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 266264003169 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 266264003170 active site 266264003171 (T/H)XGH motif; other site 266264003172 coproporphyrinogen III oxidase; Provisional; Region: PRK05330 266264003173 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218 266264003174 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 266264003175 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 266264003176 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 266264003177 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 266264003178 hypothetical protein; Validated; Region: PRK00110 266264003179 Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872 266264003180 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 266264003181 Walker A motif; other site 266264003182 ATP binding site [chemical binding]; other site 266264003183 Protein of unknown function (DUF3149); Region: DUF3149; pfam11346 266264003184 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 266264003185 active site 266264003186 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 266264003187 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 266264003188 EamA-like transporter family; Region: EamA; pfam00892 266264003189 EamA-like transporter family; Region: EamA; pfam00892 266264003190 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344 266264003191 short chain dehydrogenase; Provisional; Region: PRK07577 266264003192 putative NAD(P) binding site [chemical binding]; other site 266264003193 putative active site [active] 266264003194 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 266264003195 active site 266264003196 dimer interfaces [polypeptide binding]; other site 266264003197 catalytic residues [active] 266264003198 Uncharacterized conserved protein [Function unknown]; Region: COG3339 266264003199 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 266264003200 Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353 266264003201 putative ligand binding site [chemical binding]; other site 266264003202 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 266264003203 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 266264003204 TM-ABC transporter signature motif; other site 266264003205 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 266264003206 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 266264003207 TM-ABC transporter signature motif; other site 266264003208 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 266264003209 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 266264003210 Walker A/P-loop; other site 266264003211 ATP binding site [chemical binding]; other site 266264003212 Q-loop/lid; other site 266264003213 ABC transporter signature motif; other site 266264003214 Walker B; other site 266264003215 D-loop; other site 266264003216 H-loop/switch region; other site 266264003217 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 266264003218 Pirin-related protein [General function prediction only]; Region: COG1741 266264003219 Pirin; Region: Pirin; pfam02678 266264003220 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 266264003221 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266264003222 dimer interface [polypeptide binding]; other site 266264003223 conserved gate region; other site 266264003224 putative PBP binding loops; other site 266264003225 ABC-ATPase subunit interface; other site 266264003226 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 266264003227 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 266264003228 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266264003229 dimer interface [polypeptide binding]; other site 266264003230 conserved gate region; other site 266264003231 ABC-ATPase subunit interface; other site 266264003232 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 266264003233 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 266264003234 Walker A/P-loop; other site 266264003235 ATP binding site [chemical binding]; other site 266264003236 Q-loop/lid; other site 266264003237 ABC transporter signature motif; other site 266264003238 Walker B; other site 266264003239 D-loop; other site 266264003240 H-loop/switch region; other site 266264003241 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc; cd04582 266264003242 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 266264003243 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 266264003244 Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030 266264003245 Nodulation formation efficiency D (NfeD) is a membrane-bound ClpP-class protease; Region: Clp_protease_NfeD_1; cd07020 266264003246 active site residues [active] 266264003247 dimer interface [polypeptide binding]; other site 266264003248 NfeD-like C-terminal, partner-binding; Region: NfeD; pfam01957 266264003249 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266264003250 Major Facilitator Superfamily; Region: MFS_1; pfam07690 266264003251 putative substrate translocation pore; other site 266264003252 aldolase II superfamily protein; Provisional; Region: PRK07044 266264003253 active site 266264003254 intersubunit interface [polypeptide binding]; other site 266264003255 Zn2+ binding site [ion binding]; other site 266264003256 4-oxalocrotonate tautomerase; Provisional; Region: PRK00745 266264003257 active site 1 [active] 266264003258 dimer interface [polypeptide binding]; other site 266264003259 hexamer interface [polypeptide binding]; other site 266264003260 active site 2 [active] 266264003261 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 266264003262 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 266264003263 tetramer interface [polypeptide binding]; other site 266264003264 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266264003265 catalytic residue [active] 266264003266 ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051 266264003267 nudix motif; other site 266264003268 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 266264003269 CPxP motif; other site 266264003270 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 266264003271 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 266264003272 YaeQ protein; Region: YaeQ; pfam07152 266264003273 Uncharacterized conserved protein [Function unknown]; Region: COG2353 266264003274 Predicted membrane protein [Function unknown]; Region: COG3686 266264003275 S4 domain; Region: S4_2; pfam13275 266264003276 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 266264003277 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 266264003278 active site 266264003279 HIGH motif; other site 266264003280 nucleotide binding site [chemical binding]; other site 266264003281 catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807 266264003282 KMSKS motif; other site 266264003283 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 266264003284 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 266264003285 CoA-transferase family III; Region: CoA_transf_3; pfam02515 266264003286 PPOX class probable FMN-dependent enzyme, DR_2398 family; Region: PPOX_FMN_DR2398; TIGR04025 266264003287 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 266264003288 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 266264003289 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 266264003290 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 266264003291 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266264003292 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 266264003293 dimerization interface [polypeptide binding]; other site 266264003294 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3333 266264003295 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 266264003296 potassium/proton antiporter; Reviewed; Region: PRK05326 266264003297 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 266264003298 TrkA-C domain; Region: TrkA_C; pfam02080 266264003299 Transporter associated domain; Region: CorC_HlyC; smart01091 266264003300 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 266264003301 Predicted membrane protein (DUF2214); Region: DUF2214; pfam09980 266264003302 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 266264003303 CoA-transferase family III; Region: CoA_transf_3; pfam02515 266264003304 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 266264003305 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 266264003306 motif 1; other site 266264003307 active site 266264003308 motif 2; other site 266264003309 motif 3; other site 266264003310 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 266264003311 DHHA1 domain; Region: DHHA1; pfam02272 266264003312 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 266264003313 Alpha-Ketoglutaric Semialdehyde Dehydrogenase; Region: ALDH_KGSADH; cd07129 266264003314 dimer interface [polypeptide binding]; other site 266264003315 NADP binding site [chemical binding]; other site 266264003316 catalytic residues [active] 266264003317 Transcriptional regulators [Transcription]; Region: FadR; COG2186 266264003318 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266264003319 DNA-binding site [nucleotide binding]; DNA binding site 266264003320 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 266264003321 glucarate dehydratase; Region: glucar-dehydr; TIGR03247 266264003322 D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323 266264003323 active site 266264003324 tetramer interface [polypeptide binding]; other site 266264003325 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 266264003326 Outer membrane receptor for monomeric catechols [Inorganic ion transport and metabolism]; Region: Fiu; COG4774 266264003327 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 266264003328 N-terminal plug; other site 266264003329 ligand-binding site [chemical binding]; other site 266264003330 Fe(II)-dependent oxygenase superfamily protein; Provisional; Region: PRK05467 266264003331 Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809 266264003332 active site 266264003333 substrate binding site [chemical binding]; other site 266264003334 FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070 266264003335 FMN binding site [chemical binding]; other site 266264003336 putative catalytic residues [active] 266264003337 Transcriptional regulator [Transcription]; Region: IclR; COG1414 266264003338 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 266264003339 enoyl-CoA hydratase; Provisional; Region: PRK08290 266264003340 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 266264003341 substrate binding site [chemical binding]; other site 266264003342 oxyanion hole (OAH) forming residues; other site 266264003343 trimer interface [polypeptide binding]; other site 266264003344 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 266264003345 CoA binding domain; Region: CoA_binding_2; pfam13380 266264003346 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 266264003347 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 266264003348 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 266264003349 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 266264003350 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 266264003351 active site 266264003352 pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204 266264003353 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 266264003354 active site 266264003355 Abortive infection C-terminus; Region: Abi_C; pfam14355 266264003356 coproporphyrinogen III oxidase; Provisional; Region: PRK08898 266264003357 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 266264003358 FeS/SAM binding site; other site 266264003359 HemN C-terminal domain; Region: HemN_C; pfam06969 266264003360 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 266264003361 active site 266264003362 dimerization interface [polypeptide binding]; other site 266264003363 ribonuclease PH; Reviewed; Region: rph; PRK00173 266264003364 Ribonuclease PH; Region: RNase_PH_bact; cd11362 266264003365 hexamer interface [polypeptide binding]; other site 266264003366 active site 266264003367 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 266264003368 active site 266264003369 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 266264003370 Catalytic domain of Protein Kinases; Region: PKc; cd00180 266264003371 active site 266264003372 ATP binding site [chemical binding]; other site 266264003373 substrate binding site [chemical binding]; other site 266264003374 activation loop (A-loop); other site 266264003375 hypothetical protein; Provisional; Region: PRK11820 266264003376 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 266264003377 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 266264003378 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 266264003379 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 266264003380 catalytic site [active] 266264003381 G-X2-G-X-G-K; other site 266264003382 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 266264003383 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 266264003384 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 266264003385 Zn2+ binding site [ion binding]; other site 266264003386 Mg2+ binding site [ion binding]; other site 266264003387 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 266264003388 synthetase active site [active] 266264003389 NTP binding site [chemical binding]; other site 266264003390 metal binding site [ion binding]; metal-binding site 266264003391 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 266264003392 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 266264003393 transcription elongation factor GreB; Reviewed; Region: greB; PRK01885 266264003394 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 266264003395 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 266264003396 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4320 266264003397 Uncharacterized protein conserved in bacteria (DUF2252); Region: DUF2252; pfam10009 266264003398 Aspartyl/asparaginyl beta-hydroxylase and related dioxygenases [Posttranslational modification, protein turnover, chaperones]; Region: COG3555 266264003399 PAS domain; Region: PAS_9; pfam13426 266264003400 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 266264003401 PAS domain; Region: PAS_9; pfam13426 266264003402 putative active site [active] 266264003403 heme pocket [chemical binding]; other site 266264003404 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 266264003405 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 266264003406 metal binding site [ion binding]; metal-binding site 266264003407 active site 266264003408 I-site; other site 266264003409 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 266264003410 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266264003411 DNA-binding site [nucleotide binding]; DNA binding site 266264003412 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 266264003413 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266264003414 homodimer interface [polypeptide binding]; other site 266264003415 catalytic residue [active] 266264003416 Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509 266264003417 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 266264003418 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 266264003419 Protein of unknown function (DUF1415); Region: DUF1415; pfam07209 266264003420 Methyltransferase domain; Region: Methyltransf_32; pfam13679 266264003421 Methyltransferase domain; Region: Methyltransf_31; pfam13847 266264003422 Protein of unknown function (DUF342); Region: DUF342; pfam03961 266264003423 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 266264003424 Succinate:quinone oxidoreductase (SQR) and Quinol:fumarate reductase (QFR) family, transmembrane subunits; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol, while QFR catalyzes the reverse reaction. SQR; Region: SQR_QFR_TM; cl00881 266264003425 Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354 266264003426 AMP binding site [chemical binding]; other site 266264003427 metal binding site [ion binding]; metal-binding site 266264003428 active site 266264003429 aminopeptidase N; Provisional; Region: pepN; PRK14015 266264003430 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600 266264003431 active site 266264003432 Zn binding site [ion binding]; other site 266264003433 Domain of unknown function (DUF4136); Region: DUF4136; pfam13590 266264003434 malic enzyme; Reviewed; Region: PRK12862 266264003435 Malic enzyme, N-terminal domain; Region: malic; pfam00390 266264003436 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 266264003437 putative NAD(P) binding site [chemical binding]; other site 266264003438 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 266264003439 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 266264003440 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 266264003441 trimer interface [polypeptide binding]; other site 266264003442 eyelet of channel; other site 266264003443 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3195 266264003444 putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212 266264003445 Catalytic domain of bacterial PuuE allantoinases, Schizosaccharomyces pombe chitin deacetylase 1 (SpCDA1), and similar proteins; Region: CE4_PuuE_SpCDA1; cd10977 266264003446 active site 266264003447 catalytic site [active] 266264003448 tetramer interface [polypeptide binding]; other site 266264003449 xanthine permease; Region: pbuX; TIGR03173 266264003450 Transcriptional regulators [Transcription]; Region: GntR; COG1802 266264003451 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266264003452 DNA-binding site [nucleotide binding]; DNA binding site 266264003453 FCD domain; Region: FCD; pfam07729 266264003454 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822 266264003455 active site 266264003456 homotetramer interface [polypeptide binding]; other site 266264003457 Predicted membrane protein [Function unknown]; Region: COG3748 266264003458 Protein of unknown function (DUF989); Region: DUF989; pfam06181 266264003459 Cytochrome c; Region: Cytochrom_C; pfam00034 266264003460 Predicted membrane protein [Function unknown]; Region: COG2119 266264003461 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 266264003462 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 266264003464 Fatty acid desaturase; Region: FA_desaturase; pfam00487 266264003465 The Delta12 Fatty Acid Desaturase (Delta12-FADS)-like CD includes the integral-membrane enzymes, delta-12 acyl-lipid desaturases, oleate 12-hydroxylases, omega3 and omega6 fatty acid desaturases, and other related proteins, found in a wide range of...; Region: Delta12-FADS-like; cd03507 266264003466 putative di-iron ligands [ion binding]; other site 266264003467 guanine deaminase; Provisional; Region: PRK09228 266264003468 Guanine deaminase (GDEase). Guanine deaminase is an aminohydrolase responsible for the conversion of guanine to xanthine and ammonia, the first step to utilize guanine as a nitrogen source. This reaction also removes the guanine base from the pool and...; Region: GDEase; cd01303 266264003469 active site 266264003470 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 266264003471 Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320 266264003472 active site 266264003473 purine riboside binding site [chemical binding]; other site 266264003474 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 266264003475 xanthine dehydrogenase accessory protein XdhC; Region: xanthine_xdhC; TIGR02964 266264003476 XdhC Rossmann domain; Region: XdhC_C; pfam13478 266264003477 xanthine dehydrogenase, molybdopterin binding subunit; Region: xanthine_xdhB; TIGR02965 266264003478 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 266264003479 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 266264003480 xanthine dehydrogenase, small subunit; Region: xanthine_xdhA; TIGR02963 266264003481 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 266264003482 catalytic loop [active] 266264003483 iron binding site [ion binding]; other site 266264003484 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 266264003485 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 266264003486 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266264003487 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266264003488 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_4; cd08463 266264003489 putative substrate binding pocket [chemical binding]; other site 266264003490 putative dimerization interface [polypeptide binding]; other site 266264003491 ABC-type tungstate transport system, permease component [Coenzyme metabolism]; Region: TupB; COG2998 266264003492 PBP superfamily domain; Region: PBP_like_2; pfam12849 266264003493 N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; COG2005 266264003494 Periplasmic molybdate-binding protein/domain [Inorganic ion transport and metabolism]; Region: COG1910 266264003495 Domain of unknown function (DUF4126); Region: DUF4126; pfam13548 266264003496 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127 266264003497 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 266264003498 apolar tunnel; other site 266264003499 heme binding site [chemical binding]; other site 266264003500 dimerization interface [polypeptide binding]; other site 266264003501 Bacterial protein of unknown function (DUF924); Region: DUF924; pfam06041 266264003502 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 266264003503 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 266264003504 Bacterial transcriptional repressor; Region: TetR; pfam13972 266264003505 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 266264003506 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 266264003507 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 266264003508 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 266264003509 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 266264003510 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 266264003511 putative active site [active] 266264003512 putative metal binding site [ion binding]; other site 266264003513 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 266264003514 PGAP1-like protein; Region: PGAP1; pfam07819 266264003515 RDD family; Region: RDD; pfam06271 266264003516 Protein of unknown function (DUF3106); Region: DUF3106; pfam11304 266264003517 Protein of unknown function (DUF3619); Region: DUF3619; pfam12279 266264003518 RNA polymerase factor sigma-70; Validated; Region: PRK09047 266264003519 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 266264003520 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 266264003521 DNA binding residues [nucleotide binding] 266264003522 acetolactate synthase 3 catalytic subunit; Validated; Region: PRK06965 266264003523 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 266264003524 PYR/PP interface [polypeptide binding]; other site 266264003525 dimer interface [polypeptide binding]; other site 266264003526 TPP binding site [chemical binding]; other site 266264003527 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 266264003528 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 266264003529 TPP-binding site [chemical binding]; other site 266264003530 dimer interface [polypeptide binding]; other site 266264003531 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 266264003532 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 266264003533 putative valine binding site [chemical binding]; other site 266264003534 dimer interface [polypeptide binding]; other site 266264003535 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 266264003536 ketol-acid reductoisomerase; Provisional; Region: PRK05479 266264003537 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 266264003538 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 266264003539 phosphatidylserine decarboxylase; Provisional; Region: PRK05305 266264003540 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 266264003541 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 266264003542 LysM domain/BON superfamily protein; Provisional; Region: PRK11198 266264003543 BON domain; Region: BON; pfam04972 266264003544 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 266264003545 2-isopropylmalate synthase; Validated; Region: PRK00915 266264003546 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 266264003547 active site 266264003548 catalytic residues [active] 266264003549 metal binding site [ion binding]; metal-binding site 266264003550 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 266264003551 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 266264003552 Periplasmic solute-binding domain of active transport proteins; Region: PBP1_SBP_like_3; cd06329 266264003553 putative ligand binding site [chemical binding]; other site 266264003554 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 266264003555 16S/18S rRNA binding site [nucleotide binding]; other site 266264003556 S13e-L30e interaction site [polypeptide binding]; other site 266264003557 25S rRNA binding site [nucleotide binding]; other site 266264003558 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 266264003559 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 266264003560 RNase E interface [polypeptide binding]; other site 266264003561 trimer interface [polypeptide binding]; other site 266264003562 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 266264003563 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 266264003564 RNase E interface [polypeptide binding]; other site 266264003565 trimer interface [polypeptide binding]; other site 266264003566 active site 266264003567 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 266264003568 putative nucleic acid binding region [nucleotide binding]; other site 266264003569 G-X-X-G motif; other site 266264003570 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 266264003571 RNA binding site [nucleotide binding]; other site 266264003572 domain interface; other site 266264003573 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 266264003574 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 266264003575 NAD(P) binding site [chemical binding]; other site 266264003576 triosephosphate isomerase; Provisional; Region: PRK14567 266264003577 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 266264003578 substrate binding site [chemical binding]; other site 266264003579 dimer interface [polypeptide binding]; other site 266264003580 catalytic triad [active] 266264003581 Preprotein translocase SecG subunit; Region: SecG; cl09123 266264003582 NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602 266264003583 NADH dehydrogenase subunit B; Validated; Region: PRK06411 266264003584 NADH dehydrogenase subunit C; Provisional; Region: PRK06074 266264003585 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 266264003586 NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649 266264003587 NADH dehydrogenase subunit D; Validated; Region: PRK06075 266264003588 NADH dehydrogenase subunit E; Validated; Region: PRK07539 266264003589 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 266264003590 putative dimer interface [polypeptide binding]; other site 266264003591 [2Fe-2S] cluster binding site [ion binding]; other site 266264003592 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 266264003593 SLBB domain; Region: SLBB; pfam10531 266264003594 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928 266264003595 NADH dehydrogenase subunit G; Validated; Region: PRK09129 266264003596 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 266264003597 catalytic loop [active] 266264003598 iron binding site [ion binding]; other site 266264003599 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 266264003600 MopB_NDH-1_NuoG2: The second domain of the NuoG subunit of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1), found in beta- and gammaproteobacteria. The NDH-1 is the first energy-transducting complex in the respiratory chain and functions as...; Region: MopB_NDH-1_NuoG2; cd02772 266264003601 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cd02775 266264003602 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 266264003603 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 266264003604 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 266264003605 4Fe-4S binding domain; Region: Fer4; cl02805 266264003606 4Fe-4S binding domain; Region: Fer4; pfam00037 266264003607 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 266264003608 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 266264003609 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 266264003610 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 266264003611 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 266264003612 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 266264003613 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 266264003614 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 266264003615 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 266264003616 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 266264003617 Protein of unknown function (DUF2818); Region: DUF2818; pfam10993 266264003618 nudix-type nucleoside diphosphatase, YffH/AdpP family; Region: TIGR00052 266264003619 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 266264003620 dimer interface [polypeptide binding]; other site 266264003621 ADP-ribose binding site [chemical binding]; other site 266264003622 active site 266264003623 nudix motif; other site 266264003624 metal binding site [ion binding]; metal-binding site 266264003625 Protein of unknown function (DUF1178); Region: DUF1178; pfam06676 266264003626 pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204 266264003627 Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26; Region: ACAD_fadE6_17_26; cd01152 266264003628 FAD binding site [chemical binding]; other site 266264003629 substrate binding site [chemical binding]; other site 266264003630 catalytic base [active] 266264003631 pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203 266264003632 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 266264003633 active site 266264003634 YdeM is a Bacillus subtilis protein that belongs to a family of prokaryotic proteins of unkown function. YdeM has sequence similarity to the hot-dog fold of (R)-specific enoyl-CoA hydratase. Other enzymes with this fold include the peroxisomal...; Region: YdeM; cd03454 266264003635 putative active site [active] 266264003636 putative catalytic site [active] 266264003637 NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450 266264003638 putative active site [active] 266264003639 putative catalytic site [active] 266264003640 cytochrome o ubiquinol oxidase subunit II; Region: CyoA; TIGR01433 266264003641 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 266264003642 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 266264003643 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 266264003644 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 266264003645 D-pathway; other site 266264003646 Putative ubiquinol binding site [chemical binding]; other site 266264003647 Low-spin heme (heme b) binding site [chemical binding]; other site 266264003648 Putative water exit pathway; other site 266264003649 Binuclear center (heme o3/CuB) [ion binding]; other site 266264003650 K-pathway; other site 266264003651 Putative proton exit pathway; other site 266264003652 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 266264003653 Subunit I/III interface [polypeptide binding]; other site 266264003654 Subunit III/IV interface [polypeptide binding]; other site 266264003655 cytochrome o ubiquinol oxidase subunit IV; Region: CyoD; TIGR02847 266264003656 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 266264003657 Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355 266264003658 putative ligand binding site [chemical binding]; other site 266264003659 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 266264003660 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 266264003661 TM-ABC transporter signature motif; other site 266264003662 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 266264003663 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 266264003664 TM-ABC transporter signature motif; other site 266264003665 urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411 266264003666 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 266264003667 Walker A/P-loop; other site 266264003668 ATP binding site [chemical binding]; other site 266264003669 Q-loop/lid; other site 266264003670 ABC transporter signature motif; other site 266264003671 Walker B; other site 266264003672 D-loop; other site 266264003673 H-loop/switch region; other site 266264003674 urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410 266264003675 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 266264003676 Walker A/P-loop; other site 266264003677 ATP binding site [chemical binding]; other site 266264003678 Q-loop/lid; other site 266264003679 ABC transporter signature motif; other site 266264003680 Walker B; other site 266264003681 D-loop; other site 266264003682 H-loop/switch region; other site 266264003683 Urease accessory protein UreH [Posttranslational modification, protein turnover, chaperones]; Region: UreH; COG0829 266264003684 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 266264003685 alpha-gamma subunit interface [polypeptide binding]; other site 266264003686 beta-gamma subunit interface [polypeptide binding]; other site 266264003687 HupE / UreJ protein; Region: HupE_UreJ; pfam04955 266264003688 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 266264003689 gamma-beta subunit interface [polypeptide binding]; other site 266264003690 alpha-beta subunit interface [polypeptide binding]; other site 266264003691 urease subunit alpha; Reviewed; Region: ureC; PRK13207 266264003692 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 266264003693 subunit interactions [polypeptide binding]; other site 266264003694 active site 266264003695 flap region; other site 266264003696 urease accessory protein UreE; Provisional; Region: ureE; PRK13263 266264003697 UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571 266264003698 dimer interface [polypeptide binding]; other site 266264003699 catalytic residues [active] 266264003700 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 266264003701 UreF; Region: UreF; pfam01730 266264003702 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 266264003703 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 266264003704 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 266264003705 non-specific DNA binding site [nucleotide binding]; other site 266264003706 salt bridge; other site 266264003707 sequence-specific DNA binding site [nucleotide binding]; other site 266264003708 GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972 266264003709 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 266264003710 C-terminal domain interface [polypeptide binding]; other site 266264003711 GSH binding site (G-site) [chemical binding]; other site 266264003712 dimer interface [polypeptide binding]; other site 266264003713 C-terminal, alpha helical domain of Escherichia coli YfcG Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YfcG_like; cd10291 266264003714 N-terminal domain interface [polypeptide binding]; other site 266264003715 putative dimer interface [polypeptide binding]; other site 266264003716 active site 266264003717 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 266264003718 Acyl-CoA dehydrogenases similar to fadE2; Region: ACAD_FadE2; cd01155 266264003719 FAD binding site [chemical binding]; other site 266264003720 substrate binding site [chemical binding]; other site 266264003721 catalytic base [active] 266264003722 leucine transcriptional activator; Reviewed; Region: leuO; PRK09508 266264003723 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266264003724 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 266264003725 substrate binding pocket [chemical binding]; other site 266264003726 dimerization interface [polypeptide binding]; other site 266264003727 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 266264003728 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 266264003729 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 266264003730 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 266264003731 Phosphotransferase enzyme family; Region: APH; pfam01636 266264003732 putative active site [active] 266264003733 putative substrate binding site [chemical binding]; other site 266264003734 ATP binding site [chemical binding]; other site 266264003735 enoyl-CoA hydratase; Provisional; Region: PRK07511 266264003736 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 266264003737 substrate binding site [chemical binding]; other site 266264003738 oxyanion hole (OAH) forming residues; other site 266264003739 trimer interface [polypeptide binding]; other site 266264003740 3-hydroxy-acyl-CoA dehydrogenase; Validated; Region: PRK08268 266264003741 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 266264003742 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 266264003743 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 266264003744 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 266264003745 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 266264003746 C-terminal domain interface [polypeptide binding]; other site 266264003747 GSH binding site (G-site) [chemical binding]; other site 266264003748 dimer interface [polypeptide binding]; other site 266264003749 C-terminal, alpha helical domain of an unknown subfamily 9 of Glutathione S-transferases; Region: GST_C_9; cd10424 266264003750 putative N-terminal domain interface [polypeptide binding]; other site 266264003751 putative dimer interface [polypeptide binding]; other site 266264003752 putative substrate binding pocket (H-site) [chemical binding]; other site 266264003753 methionine aminotransferase; Validated; Region: PRK09082 266264003754 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 266264003755 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266264003756 homodimer interface [polypeptide binding]; other site 266264003757 catalytic residue [active] 266264003758 PIN domain; Region: PIN_3; cl17397 266264003759 hypothetical protein; Validated; Region: PRK02101 266264003760 Predicted carboxypeptidase [Amino acid transport and metabolism]; Region: COG2866 266264003761 Peptidase M14-like domain of ATP/GTP binding proteins and cytosolic carboxypeptidases; uncharacterized bacterial subgroup; Region: M14_Nna1_like_1; cd06234 266264003762 putative active site [active] 266264003763 Zn binding site [ion binding]; other site 266264003764 N-formylglutamate amidohydrolase; Region: FGase; pfam05013 266264003765 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 266264003766 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 266264003767 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266264003768 The C-terminal substrate binding domain of LysR-type transcriptional regulators GcdR-like, contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_like; cd08481 266264003769 dimerization interface [polypeptide binding]; other site 266264003770 substrate binding pocket [chemical binding]; other site 266264003771 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3825 266264003772 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 266264003773 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 266264003774 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 266264003775 Walker A motif; other site 266264003776 ATP binding site [chemical binding]; other site 266264003777 Walker B motif; other site 266264003778 arginine finger; other site 266264003779 Cytochrome c553 [Energy production and conversion]; Region: COG2863 266264003780 Cytochrome c; Region: Cytochrom_C; cl11414 266264003781 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 266264003782 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 266264003783 Methyltransferase domain; Region: Methyltransf_31; pfam13847 266264003784 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 266264003785 S-adenosylmethionine binding site [chemical binding]; other site 266264003786 protease TldD; Provisional; Region: tldD; PRK10735 266264003787 nitrilase; Region: PLN02798 266264003788 Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572 266264003789 putative active site [active] 266264003790 catalytic triad [active] 266264003791 dimer interface [polypeptide binding]; other site 266264003792 Predicted membrane protein [Function unknown]; Region: COG3164 266264003793 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 266264003794 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Reviewed; Region: PRK11072 266264003795 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 266264003796 metal binding triad; other site 266264003797 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 266264003798 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 266264003799 metal binding triad; other site 266264003800 rhomboid family GlyGly-CTERM serine protease; Region: rhom_GG_sort; TIGR03902 266264003801 Peptidase S8 family domain, uncharacterized subfamily 13; Region: Peptidases_S8_13; cd07496 266264003802 active site 266264003803 catalytic triad [active] 266264003804 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 266264003805 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 266264003806 Walker A/P-loop; other site 266264003807 ATP binding site [chemical binding]; other site 266264003808 Q-loop/lid; other site 266264003809 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 266264003810 ABC transporter signature motif; other site 266264003811 Walker B; other site 266264003812 D-loop; other site 266264003813 H-loop/switch region; other site 266264003814 NAD(+)/NADH kinase family protein; Provisional; Region: ppnK; PRK02155 266264003815 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02231 266264003816 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 266264003817 Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444 266264003818 ferrochelatase; Reviewed; Region: hemH; PRK00035 266264003819 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 266264003820 C-terminal domain interface [polypeptide binding]; other site 266264003821 active site 266264003822 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 266264003823 active site 266264003824 N-terminal domain interface [polypeptide binding]; other site 266264003825 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 266264003826 RNA binding surface [nucleotide binding]; other site 266264003827 GrpE; Region: GrpE; pfam01025 266264003828 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 266264003829 dimer interface [polypeptide binding]; other site 266264003830 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 266264003831 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 266264003832 catalytic residues [active] 266264003833 The outer membrane phospholipase A (OMPLA) is an integral membrane enzyme that catalyses the hydrolysis of acylester bonds in phospholipids using calcium as a cofactor. The enzyme has a fold of transmembrane beta-barrels and is widespread among...; Region: OMPLA; cd00541 266264003834 dimerization interface [polypeptide binding]; other site 266264003835 substrate binding site [chemical binding]; other site 266264003836 active site 266264003837 calcium binding site [ion binding]; other site 266264003838 Domain of unknown function (DUF1841); Region: DUF1841; pfam08897 266264003839 EamA-like transporter family; Region: EamA; cl17759 266264003840 Nitroreductase-like family 5. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_5; cd02148 266264003841 putative FMN binding site [chemical binding]; other site 266264003842 Coenzyme Q (ubiquinone) biosynthesis protein Coq4; Region: Coq4; cl02093 266264003843 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 266264003844 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 266264003845 catalytic site [active] 266264003846 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 266264003847 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 266264003848 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 266264003849 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 266264003850 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 266264003851 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 266264003852 minor groove reading motif; other site 266264003853 helix-hairpin-helix signature motif; other site 266264003854 substrate binding pocket [chemical binding]; other site 266264003855 active site 266264003856 ferredoxin; Provisional; Region: PRK06991 266264003857 Putative Fe-S cluster; Region: FeS; pfam04060 266264003858 4Fe-4S binding domain; Region: Fer4; pfam00037 266264003859 pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613 266264003860 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 266264003861 Poly-beta-hydroxyalkanoate depolymerase [Lipid metabolism]; Region: DepA; COG4553 266264003862 PHB de-polymerase C-terminus; Region: PHB_depo_C; pfam06850 266264003863 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 266264003864 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 266264003865 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266264003866 homodimer interface [polypeptide binding]; other site 266264003867 catalytic residue [active] 266264003868 excinuclease ABC subunit B; Provisional; Region: PRK05298 266264003869 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 266264003870 ATP binding site [chemical binding]; other site 266264003871 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 266264003872 nucleotide binding region [chemical binding]; other site 266264003873 ATP-binding site [chemical binding]; other site 266264003874 Ultra-violet resistance protein B; Region: UvrB; pfam12344 266264003875 UvrB/uvrC motif; Region: UVR; pfam02151 266264003876 Low molecular weight phosphatase family; Region: LMWPc; cd00115 266264003877 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 266264003878 active site 266264003879 Site-specific recombinase; Region: SpecificRecomb; pfam10136 266264003880 Predicted transcriptional regulator [Transcription]; Region: COG1959 266264003881 iron-sulfur cluster assembly transcription factor IscR; Region: IscR; TIGR02010 266264003882 cysteine desulfurase; Provisional; Region: PRK14012 266264003883 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 266264003884 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 266264003885 catalytic residue [active] 266264003886 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 266264003887 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 266264003888 trimerization site [polypeptide binding]; other site 266264003889 active site 266264003890 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 266264003891 co-chaperone HscB; Provisional; Region: hscB; PRK03578 266264003892 DnaJ domain; Region: DnaJ; pfam00226 266264003893 HSP70 interaction site [polypeptide binding]; other site 266264003894 HSCB C-terminal oligomerisation domain; Region: HSCB_C; pfam07743 266264003895 chaperone protein HscA; Provisional; Region: hscA; PRK05183 266264003896 Nucleotide-binding domain of HscA and similar proteins; Region: HscA_like_NBD; cd10236 266264003897 nucleotide binding site [chemical binding]; other site 266264003898 putative NEF/HSP70 interaction site [polypeptide binding]; other site 266264003899 SBD interface [polypeptide binding]; other site 266264003900 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 266264003901 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 266264003902 catalytic loop [active] 266264003903 iron binding site [ion binding]; other site 266264003904 Iron-sulphur cluster assembly; Region: Fe-S_assembly; pfam04384 266264003905 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 266264003906 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 266264003907 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 266264003908 dimer interface [polypeptide binding]; other site 266264003909 putative anticodon binding site; other site 266264003910 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 266264003911 motif 1; other site 266264003912 active site 266264003913 motif 2; other site 266264003914 motif 3; other site 266264003915 short chain dehydrogenase; Provisional; Region: PRK07023 266264003916 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266264003917 NAD(P) binding site [chemical binding]; other site 266264003918 active site 266264003919 peptide chain release factor 2; Validated; Region: prfB; PRK00578 266264003920 This domain is found in peptide chain release factors; Region: PCRF; smart00937 266264003921 RF-1 domain; Region: RF-1; pfam00472 266264003922 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 266264003923 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 266264003924 Peptidase family M23; Region: Peptidase_M23; pfam01551 266264003925 ssDNA exonuclease RecJ; Provisional; Region: PRK11070 266264003926 DHH family; Region: DHH; pfam01368 266264003927 DHHA1 domain; Region: DHHA1; pfam02272 266264003928 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4255 266264003929 lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212 266264003930 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 266264003931 FtsX-like permease family; Region: FtsX; pfam02687 266264003932 lipoprotein releasing system, ATP-binding protein; Region: LolD_lipo_ex; TIGR02211 266264003933 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 266264003934 Walker A/P-loop; other site 266264003935 ATP binding site [chemical binding]; other site 266264003936 Q-loop/lid; other site 266264003937 ABC transporter signature motif; other site 266264003938 Walker B; other site 266264003939 D-loop; other site 266264003940 H-loop/switch region; other site 266264003941 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 266264003942 active site 266264003943 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 266264003944 DNA internalization-related competence protein ComEC/Rec2; Region: ComEC_Rec2; TIGR00361 266264003945 Competence protein; Region: Competence; pfam03772 266264003946 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 266264003947 DNA-binding transcriptional regulator HexR; Provisional; Region: PRK11302 266264003948 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 266264003949 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 266264003950 putative active site [active] 266264003951 6-phosphogluconate dehydratase; Region: edd; TIGR01196 266264003952 phosphogluconate dehydratase; Validated; Region: PRK09054 266264003953 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 266264003954 ATP-binding site [chemical binding]; other site 266264003955 Gluconate-6-phosphate binding site [chemical binding]; other site 266264003956 Shikimate kinase; Region: SKI; pfam01202 266264003957 Uncharacterized conserved protein [Function unknown]; Region: COG2308 266264003958 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 266264003959 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 266264003960 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 266264003961 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 266264003962 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 266264003963 Predicted proteasome-type protease [Posttranslational modification, protein turnover, chaperones]; Region: COG3484 266264003964 Bacterial proteasome, beta subunit. The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that...; Region: proteasome_beta_bacterial; cd03765 266264003965 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 266264003966 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 266264003967 CTP synthetase; Validated; Region: pyrG; PRK05380 266264003968 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 266264003969 Catalytic site [active] 266264003970 active site 266264003971 UTP binding site [chemical binding]; other site 266264003972 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 266264003973 active site 266264003974 putative oxyanion hole; other site 266264003975 catalytic triad [active] 266264003976 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198 266264003977 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 266264003978 Uncharacterized conserved protein [Function unknown]; Region: COG5470 266264003979 enolase; Provisional; Region: eno; PRK00077 266264003980 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 266264003981 dimer interface [polypeptide binding]; other site 266264003982 metal binding site [ion binding]; metal-binding site 266264003983 substrate binding pocket [chemical binding]; other site 266264003984 cell division protein FtsB; Reviewed; Region: ftsB; PRK00888 266264003985 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 266264003986 Protein of unknown function (DUF2680); Region: DUF2680; pfam10925 266264003987 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 266264003988 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 266264003989 dimerization interface [polypeptide binding]; other site 266264003990 domain crossover interface; other site 266264003991 redox-dependent activation switch; other site 266264003992 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 266264003993 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 266264003994 trimer interface [polypeptide binding]; other site 266264003995 putative metal binding site [ion binding]; other site 266264003996 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 266264003997 dinuclear metal binding motif [ion binding]; other site 266264003998 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 266264003999 Uncharacterized subfamily of medium-chain acyl-CoA synthetase (MACS); Region: MACS_like_3; cd05971 266264004000 active site 266264004001 acyl-activating enzyme (AAE) consensus motif; other site 266264004002 putative CoA binding site [chemical binding]; other site 266264004003 AMP binding site [chemical binding]; other site 266264004004 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 266264004005 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 266264004006 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 266264004007 catalytic site [active] 266264004008 Serine carboxypeptidase; Region: Peptidase_S10; cl08270 266264004009 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 266264004010 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 266264004011 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 266264004012 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 266264004013 active site 266264004014 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 266264004015 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 266264004016 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 266264004017 Peptidase family M50; Region: Peptidase_M50; pfam02163 266264004018 active site 266264004019 putative substrate binding region [chemical binding]; other site 266264004020 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 266264004021 S-adenosylmethionine binding site [chemical binding]; other site 266264004022 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 266264004023 dihydrodipicolinate synthase; Region: dapA; TIGR00674 266264004024 dimer interface [polypeptide binding]; other site 266264004025 active site 266264004026 catalytic residue [active] 266264004027 Uncharacterized lipoprotein [Cell envelope biogenesis, outer membrane]; Region: NlpB; COG3317 266264004028 NlpB/DapX lipoprotein; Region: Lipoprotein_18; pfam06804 266264004029 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 266264004030 Uncharacterized conserved protein [Function unknown]; Region: COG2850 266264004031 Cupin-like domain; Region: Cupin_8; pfam13621 266264004032 FKBP-type peptidyl-prolyl cis-trans isomerases 2 [Posttranslational modification, protein turnover, chaperones]; Region: SlpA; COG1047 266264004033 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 266264004034 MutS domain I; Region: MutS_I; pfam01624 266264004035 MutS domain II; Region: MutS_II; pfam05188 266264004036 MutS domain III; Region: MutS_III; pfam05192 266264004037 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 266264004038 Walker A/P-loop; other site 266264004039 ATP binding site [chemical binding]; other site 266264004040 Q-loop/lid; other site 266264004041 ABC transporter signature motif; other site 266264004042 Walker B; other site 266264004043 D-loop; other site 266264004044 H-loop/switch region; other site 266264004045 Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681 266264004046 YcfA-like protein; Region: YcfA; pfam07927 266264004047 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 266264004048 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 266264004049 active site 266264004050 dimerization interface [polypeptide binding]; other site 266264004051 rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565 266264004052 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 266264004053 serine O-acetyltransferase; Region: cysE; TIGR01172 266264004054 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 266264004055 trimer interface [polypeptide binding]; other site 266264004056 active site 266264004057 substrate binding site [chemical binding]; other site 266264004058 CoA binding site [chemical binding]; other site 266264004059 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 266264004060 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 266264004061 putative active site [active] 266264004062 putative metal binding site [ion binding]; other site 266264004063 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 266264004064 substrate binding site [chemical binding]; other site 266264004065 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cl00197 266264004066 active site 266264004067 Tetratricopeptide repeat; Region: TPR_16; pfam13432 266264004068 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 266264004069 TPR motif; other site 266264004070 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 266264004071 binding surface 266264004072 TPR motif; other site 266264004073 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 266264004074 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 266264004075 active site 266264004076 HIGH motif; other site 266264004077 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 266264004078 KMSKS motif; other site 266264004079 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 266264004080 tRNA binding surface [nucleotide binding]; other site 266264004081 anticodon binding site; other site 266264004082 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 266264004083 endonuclease III; Region: ENDO3c; smart00478 266264004084 minor groove reading motif; other site 266264004085 helix-hairpin-helix signature motif; other site 266264004086 substrate binding pocket [chemical binding]; other site 266264004087 active site 266264004088 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 266264004089 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 266264004090 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 266264004091 tRNA(Ile)-lysidine synthetase; Provisional; Region: tilS; PRK10660 266264004092 Ligand Binding Site [chemical binding]; other site 266264004093 TilS substrate binding domain; Region: TilS; pfam09179 266264004094 TilS substrate C-terminal domain; Region: TilS_C; pfam11734 266264004095 aspartate kinase; Reviewed; Region: PRK06635 266264004096 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 266264004097 putative nucleotide binding site [chemical binding]; other site 266264004098 putative catalytic residues [active] 266264004099 putative Mg ion binding site [ion binding]; other site 266264004100 putative aspartate binding site [chemical binding]; other site 266264004101 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 266264004102 putative allosteric regulatory site; other site 266264004103 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 266264004104 Predicted signal transduction protein containing sensor and EAL domains [Signal transduction mechanisms]; Region: COG4943 266264004105 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 266264004106 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 266264004107 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 266264004108 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 266264004109 metal binding site [ion binding]; metal-binding site 266264004110 active site 266264004111 I-site; other site 266264004112 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 266264004113 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 266264004114 transmembrane helices; other site 266264004115 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 266264004116 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 266264004117 NAD binding site [chemical binding]; other site 266264004118 substrate binding site [chemical binding]; other site 266264004119 catalytic Zn binding site [ion binding]; other site 266264004120 tetramer interface [polypeptide binding]; other site 266264004121 structural Zn binding site [ion binding]; other site 266264004122 Surface antigen; Region: Bac_surface_Ag; pfam01103 266264004123 Surface antigen; Region: Bac_surface_Ag; pfam01103 266264004124 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 266264004125 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 266264004126 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 266264004127 putative GTP cyclohydrolase; Provisional; Region: PRK13674 266264004128 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 266264004129 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 266264004130 active site 266264004131 HIGH motif; other site 266264004132 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 266264004133 KMSKS motif; other site 266264004134 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 266264004135 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 266264004136 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 266264004137 Gamma carbonic anhydrases (CA): Carbonic anhydrases are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism, involving the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide, followed...; Region: LbH_gamma_CA; cd00710 266264004138 trimer interface [polypeptide binding]; other site 266264004139 active site 266264004140 dihydroorotase; Validated; Region: PRK09060 266264004141 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 266264004142 Dihydroorotase (DHOase), subgroup IIb; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This group contains the archeal members of the DHOase family; Region: DHOase_IIb; cd01318 266264004143 active site 266264004144 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 266264004145 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 266264004146 N-terminal plug; other site 266264004147 ligand-binding site [chemical binding]; other site 266264004148 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 266264004149 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 266264004150 Protein of unknown function (DUF3325); Region: DUF3325; pfam11804 266264004151 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 266264004152 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 266264004153 N-terminal plug; other site 266264004154 ligand-binding site [chemical binding]; other site 266264004155 Protein of unknown function (DUF3478); Region: DUF3478; pfam11964 266264004156 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme PvsE; Region: PLPDE_III_PvsE_like; cd06843 266264004157 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 266264004158 active site 266264004159 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 266264004160 dimer interface [polypeptide binding]; other site 266264004161 catalytic residues [active] 266264004162 substrate binding site [chemical binding]; other site 266264004163 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 266264004164 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 266264004165 IucA / IucC family; Region: IucA_IucC; pfam04183 266264004166 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 266264004167 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 266264004168 IucA / IucC family; Region: IucA_IucC; pfam04183 266264004169 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 266264004170 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266264004171 putative substrate translocation pore; other site 266264004172 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 266264004173 IucA / IucC family; Region: IucA_IucC; pfam04183 266264004174 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 266264004175 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 266264004176 2,3-diaminopropionate biosynthesis protein SbnB; Region: dehyd_SbnB_fam; TIGR03944 266264004177 2,3-diaminopropionate biosynthesis protein SbnA; Region: PLP_SbnA_fam; TIGR03945 266264004178 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 266264004179 dimer interface [polypeptide binding]; other site 266264004180 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266264004181 catalytic residue [active] 266264004182 Secretin and TonB N terminus short domain; Region: STN; smart00965 266264004183 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 266264004184 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 266264004185 N-terminal plug; other site 266264004186 ligand-binding site [chemical binding]; other site 266264004187 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 266264004188 FecR protein; Region: FecR; pfam04773 266264004189 RNA polymerase sigma factor; Reviewed; Region: PRK12527 266264004190 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 266264004191 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 266264004192 DNA binding residues [nucleotide binding] 266264004193 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 266264004194 Protein export membrane protein; Region: SecD_SecF; cl14618 266264004195 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 266264004196 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 266264004197 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 266264004198 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 266264004199 substrate binding pocket [chemical binding]; other site 266264004200 membrane-bound complex binding site; other site 266264004201 hinge residues; other site 266264004202 oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701 266264004203 The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767 266264004204 putative molybdopterin cofactor binding site [chemical binding]; other site 266264004205 The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787 266264004206 putative molybdopterin cofactor binding site; other site 266264004207 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 266264004208 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 266264004209 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266264004210 DNA-binding site [nucleotide binding]; DNA binding site 266264004211 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 266264004212 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266264004213 homodimer interface [polypeptide binding]; other site 266264004214 catalytic residue [active] 266264004215 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 266264004216 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 266264004217 FAD binding domain; Region: FAD_binding_4; pfam01565 266264004218 Predicted membrane protein (DUF2069); Region: DUF2069; pfam09842 266264004219 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 266264004220 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 266264004221 ribonuclease BN/unknown domain fusion protein; Reviewed; Region: rbn; PRK04214 266264004222 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 266264004223 Protein of unknown function (DUF962); Region: DUF962; cl01879 266264004224 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 266264004225 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 266264004226 O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK08134 266264004227 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 266264004228 homodimer interface [polypeptide binding]; other site 266264004229 substrate-cofactor binding pocket; other site 266264004230 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266264004231 catalytic residue [active] 266264004232 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 266264004233 FOG: CBS domain [General function prediction only]; Region: COG0517 266264004234 lysophospholipid transporter LplT; Provisional; Region: PRK11195 266264004235 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266264004236 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 266264004237 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 266264004238 putative acyl-acceptor binding pocket; other site 266264004239 GST_N family, Metaxin subfamily, Metaxin-like proteins; a heterogenous group of proteins, predominantly uncharacterized, with similarity to metaxins and GSTs. Metaxin 1 is a component of a preprotein import complex of the mitochondrial outer membrane. It...; Region: GST_N_Metaxin_like; cd03080 266264004240 putative C-terminal domain interface [polypeptide binding]; other site 266264004241 putative GSH binding site [chemical binding]; other site 266264004242 putative dimer interface [polypeptide binding]; other site 266264004243 C-terminal, alpha helical domain of Metaxin and related proteins; Region: GST_C_Metaxin; cd03193 266264004244 putative N-terminal domain interface [polypeptide binding]; other site 266264004245 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 266264004246 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 266264004247 Tetramer interface [polypeptide binding]; other site 266264004248 active site 266264004249 FMN-binding site [chemical binding]; other site 266264004250 MFS_1 like family; Region: MFS_1_like; pfam12832 266264004251 putative 3-phenylpropionic acid transporter; Provisional; Region: PRK11128 266264004252 hydroxyglutarate oxidase; Provisional; Region: PRK11728 266264004253 Predicted dehydrogenase [General function prediction only]; Region: COG0579 266264004254 Transcriptional regulators [Transcription]; Region: FadR; COG2186 266264004255 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266264004256 DNA-binding site [nucleotide binding]; DNA binding site 266264004257 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 266264004258 Flagellar protein YcgR; Region: YcgR_2; pfam12945 266264004259 PilZ domain; Region: PilZ; pfam07238 266264004260 Cytochrome c; Region: Cytochrom_C; pfam00034 266264004261 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 266264004262 Cytochrome c; Region: Cytochrom_C; pfam00034 266264004263 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 266264004264 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769 266264004265 molybdopterin guanine dinucleotide-containing S/N-oxide reductases; Region: bisC_fam; TIGR00509 266264004266 molybdopterin cofactor binding site [chemical binding]; other site 266264004267 substrate binding site [chemical binding]; other site 266264004268 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793 266264004269 molybdopterin cofactor binding site; other site 266264004270 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 266264004271 hydroxyglutarate oxidase; Provisional; Region: PRK11728 266264004272 Electron transfer flavoprotein-ubiquinone oxidoreductase; Region: ETF_QO; pfam05187 266264004273 short chain dehydrogenase; Provisional; Region: PRK06949 266264004274 classical (c) SDRs; Region: SDR_c; cd05233 266264004275 NAD(P) binding site [chemical binding]; other site 266264004276 active site 266264004277 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290 266264004278 DctM-like transporters; Region: DctM; pfam06808 266264004279 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 266264004280 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 266264004281 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 266264004282 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 266264004283 active site 266264004284 PAS domain; Region: PAS_9; pfam13426 266264004285 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 266264004286 putative active site [active] 266264004287 heme pocket [chemical binding]; other site 266264004288 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 266264004289 DNA binding residues [nucleotide binding] 266264004290 dimerization interface [polypeptide binding]; other site 266264004291 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 266264004292 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 266264004293 Predicted metal-binding protein [General function prediction only]; Region: COG3019 266264004294 3-hydroxybutyrate dehydrogenase; Provisional; Region: PRK12429 266264004295 d-3-hydroxybutyrate dehydrogenase (HBDH), classical (c) SDRs; Region: HBDH_SDR_c; cd08940 266264004296 NAD binding site [chemical binding]; other site 266264004297 homotetramer interface [polypeptide binding]; other site 266264004298 homodimer interface [polypeptide binding]; other site 266264004299 substrate binding site [chemical binding]; other site 266264004300 active site 266264004301 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 266264004302 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 266264004303 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150 266264004304 homotrimer interaction site [polypeptide binding]; other site 266264004305 putative active site [active] 266264004306 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 266264004307 HD domain; Region: HD_4; pfam13328 266264004308 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 266264004309 synthetase active site [active] 266264004310 NTP binding site [chemical binding]; other site 266264004311 metal binding site [ion binding]; metal-binding site 266264004312 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 266264004313 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 266264004314 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 266264004315 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 266264004316 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 266264004317 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 266264004318 active site 266264004319 dimer interface [polypeptide binding]; other site 266264004320 motif 1; other site 266264004321 motif 2; other site 266264004322 motif 3; other site 266264004323 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 266264004324 anticodon binding site; other site 266264004325 translation initiation factor IF-3; Region: infC; TIGR00168 266264004326 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 266264004327 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 266264004328 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 266264004329 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 266264004330 23S rRNA binding site [nucleotide binding]; other site 266264004331 L21 binding site [polypeptide binding]; other site 266264004332 L13 binding site [polypeptide binding]; other site 266264004333 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 266264004334 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 266264004335 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 266264004336 dimer interface [polypeptide binding]; other site 266264004337 motif 1; other site 266264004338 active site 266264004339 motif 2; other site 266264004340 motif 3; other site 266264004341 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 266264004342 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 266264004343 putative tRNA-binding site [nucleotide binding]; other site 266264004344 B3/4 domain; Region: B3_4; pfam03483 266264004345 tRNA synthetase B5 domain; Region: B5; smart00874 266264004346 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 266264004347 dimer interface [polypeptide binding]; other site 266264004348 motif 1; other site 266264004349 motif 3; other site 266264004350 motif 2; other site 266264004351 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; smart00896 266264004352 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 266264004353 IHF - DNA interface [nucleotide binding]; other site 266264004354 IHF dimer interface [polypeptide binding]; other site 266264004355 Helix-Turn-Helix DNA binding domain of putative MlrA-like transcription regulators; Region: HTH_MlrA-like_sg2; cd04765 266264004356 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 266264004357 DNA binding residues [nucleotide binding] 266264004358 Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360 266264004359 sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570 266264004360 putative trimer interface [polypeptide binding]; other site 266264004361 putative CoA binding site [chemical binding]; other site 266264004362 methionine sulfoxide reductase A; Provisional; Region: PRK13014 266264004363 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 266264004364 TlpA-like family, DipZ-like subfamily; composed uncharacterized proteins containing a TlpA-like TRX domain. Some members show domain architectures similar to that of E. coli DipZ protein (also known as DsbD). The only eukaryotic members of the TlpA...; Region: TlpA_like_DipZ_like; cd03012 266264004365 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 266264004366 catalytic residues [active] 266264004367 Transposase domain (DUF772); Region: DUF772; pfam05598 266264004368 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 266264004369 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 266264004370 Protein-methionine-S-oxide reductase 266264004371 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 266264004372 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266264004373 active site 266264004374 phosphorylation site [posttranslational modification] 266264004375 intermolecular recognition site; other site 266264004376 dimerization interface [polypeptide binding]; other site 266264004377 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 266264004378 DNA binding site [nucleotide binding] 266264004379 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 266264004380 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 266264004381 dimerization interface [polypeptide binding]; other site 266264004382 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 266264004383 dimer interface [polypeptide binding]; other site 266264004384 phosphorylation site [posttranslational modification] 266264004385 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266264004386 ATP binding site [chemical binding]; other site 266264004387 Mg2+ binding site [ion binding]; other site 266264004388 G-X-G motif; other site 266264004389 DNA-binding transcriptional regulator DsdC; Provisional; Region: PRK10086 266264004390 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266264004391 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 266264004392 dimerization interface [polypeptide binding]; other site 266264004393 enolase; Provisional; Region: eno; PRK00077 266264004394 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 266264004395 dimer interface [polypeptide binding]; other site 266264004396 metal binding site [ion binding]; metal-binding site 266264004397 substrate binding pocket [chemical binding]; other site 266264004398 hydrogenase nickel incorporation protein; Provisional; Region: hypA; PRK03824 266264004399 Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088 266264004400 hypothetical protein 266264004401 hypothetical protein 266264004402 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 266264004403 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266264004404 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266264004405 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 266264004406 dimerization interface [polypeptide binding]; other site 266264004407 hydroxydechloroatrazine ethylaminohydrolase; Reviewed; Region: PRK08203 266264004408 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 266264004409 active site 266264004410 putative substrate binding pocket [chemical binding]; other site 266264004411 Protein of unknown function (DUF1488); Region: DUF1488; pfam07369 266264004412 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 266264004413 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 266264004414 Sulfate transporter family; Region: Sulfate_transp; pfam00916 266264004415 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 266264004416 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 266264004417 putative catalytic site [active] 266264004418 putative phosphate binding site [ion binding]; other site 266264004419 active site 266264004420 metal binding site A [ion binding]; metal-binding site 266264004421 DNA binding site [nucleotide binding] 266264004422 putative AP binding site [nucleotide binding]; other site 266264004423 putative metal binding site B [ion binding]; other site 266264004424 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 266264004425 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 266264004426 active site 266264004427 Zn binding site [ion binding]; other site 266264004428 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14189 266264004429 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 266264004430 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 266264004431 homodimer interface [polypeptide binding]; other site 266264004432 NADP binding site [chemical binding]; other site 266264004433 substrate binding site [chemical binding]; other site 266264004434 Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891 266264004435 Predicted membrane protein [Function unknown]; Region: COG3235 266264004436 Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566 266264004437 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266264004438 active site 266264004439 phosphorylation site [posttranslational modification] 266264004440 intermolecular recognition site; other site 266264004441 dimerization interface [polypeptide binding]; other site 266264004442 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 266264004443 DNA binding residues [nucleotide binding] 266264004444 dimerization interface [polypeptide binding]; other site 266264004445 PAS domain S-box; Region: sensory_box; TIGR00229 266264004446 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 266264004447 putative active site [active] 266264004448 heme pocket [chemical binding]; other site 266264004449 PAS domain S-box; Region: sensory_box; TIGR00229 266264004450 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 266264004451 dimer interface [polypeptide binding]; other site 266264004452 phosphorylation site [posttranslational modification] 266264004453 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266264004454 ATP binding site [chemical binding]; other site 266264004455 Mg2+ binding site [ion binding]; other site 266264004456 G-X-G motif; other site 266264004457 hypothetical protein 266264004458 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 266264004459 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 266264004460 dimer interface [polypeptide binding]; other site 266264004461 TPP-binding site [chemical binding]; other site 266264004462 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 266264004463 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11855 266264004464 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 266264004465 E3 interaction surface; other site 266264004466 lipoyl attachment site [posttranslational modification]; other site 266264004467 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 266264004468 E3 interaction surface; other site 266264004469 lipoyl attachment site [posttranslational modification]; other site 266264004470 e3 binding domain; Region: E3_binding; pfam02817 266264004471 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 266264004472 proteasome_protease_HslV. This group contains the eukaryotic proteosome alpha and beta subunits and the prokaryotic protease hslV subunit. Proteasomes are large multimeric self-compartmentalizing proteases, involved in the clearance of misfolded proteins; Region: proteasome_protease_HslV; cd01906 266264004473 active site 266264004474 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 266264004475 E3 interaction surface; other site 266264004476 lipoyl attachment site [posttranslational modification]; other site 266264004477 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467 266264004478 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 266264004479 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 266264004480 Phasin protein; Region: Phasin_2; pfam09361 266264004481 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 266264004482 Histone deacetylase class IV also known as histone deacetylase 11; Region: HDAC_classIV; cd09993 266264004483 putative active site [active] 266264004484 Zn binding site [ion binding]; other site 266264004485 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 266264004486 active site 266264004487 Nitroreductase family. Members of this family utilize FMN as a cofactor and catalyze reduction of a variety of nitroaromatic compounds, including nitrofurans, nitrobenzens, nitrophenol, nitrobenzoate and quinones by using either NADH or NADPH as a source...; Region: Nitroreductase; cd02136 266264004488 putative FMN binding site [chemical binding]; other site 266264004489 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 266264004490 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 266264004491 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 266264004492 Transcriptional regulator [Transcription]; Region: IclR; COG1414 266264004493 Bacterial transcriptional regulator; Region: IclR; pfam01614 266264004494 CoB--CoM heterodisulfide reductase, subunit B; Region: CoB_CoM_SS_B; TIGR03288 266264004495 Cysteine-rich domain; Region: CCG; pfam02754 266264004496 Cysteine-rich domain; Region: CCG; pfam02754 266264004497 Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139 266264004498 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 266264004499 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 266264004500 Domain of unknown function (DUF3390); Region: DUF3390; pfam11870 266264004501 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101 266264004502 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 266264004503 Walker A/P-loop; other site 266264004504 ATP binding site [chemical binding]; other site 266264004505 Q-loop/lid; other site 266264004506 ABC transporter signature motif; other site 266264004507 Walker B; other site 266264004508 D-loop; other site 266264004509 H-loop/switch region; other site 266264004510 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 266264004511 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574 266264004512 TM-ABC transporter signature motif; other site 266264004513 Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325 266264004514 zinc binding site [ion binding]; other site 266264004515 putative ligand binding site [chemical binding]; other site 266264004516 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 266264004517 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 266264004518 active site 266264004519 catalytic tetrad [active] 266264004520 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 266264004521 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 266264004522 quinone interaction residues [chemical binding]; other site 266264004523 active site 266264004524 catalytic residues [active] 266264004525 FMN binding site [chemical binding]; other site 266264004526 substrate binding site [chemical binding]; other site 266264004527 arginyl-tRNA-protein transferase; Provisional; Region: PRK01305 266264004528 Arginine-tRNA-protein transferase, N terminus; Region: ATE_N; pfam04376 266264004529 Arginine-tRNA-protein transferase, C terminus; Region: ATE_C; pfam04377 266264004530 leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301 266264004531 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_4; cd04511 266264004532 nudix motif; other site 266264004533 RES domain; Region: RES; smart00953 266264004534 putative toxin-antitoxin system antitoxin component, TIGR02293 family; Region: TAS_TIGR02293 266264004535 Protein of unknown function (DUF2384); Region: DUF2384; pfam09722 266264004536 benzoyl-CoA oxygenase/reductase, BoxA protein; Region: benzo_boxA; TIGR03224 266264004537 4Fe-4S binding domain; Region: Fer4; pfam00037 266264004538 These ferredoxin reductases are related to the NADPH cytochrome p450 reductases (CYPOR), but lack the FAD-binding region connecting sub-domain. Ferredoxin-NADP+ reductase (FNR) is an FAD-containing enzyme that catalyzes the reversible electron transfer...; Region: CYPOR_like_FNR; cd06208 266264004539 dimerization interface [polypeptide binding]; other site 266264004540 FAD binding pocket [chemical binding]; other site 266264004541 FAD binding motif [chemical binding]; other site 266264004542 catalytic residues [active] 266264004543 NAD binding pocket [chemical binding]; other site 266264004544 phosphate binding motif [ion binding]; other site 266264004545 beta-alpha-beta structure motif; other site 266264004546 Phenylacetic acid catabolic protein; Region: PaaA_PaaC; cl01346 266264004547 benzoyl-CoA-dihydrodiol lyase; Provisional; Region: PRK08184 266264004548 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 266264004549 substrate binding site [chemical binding]; other site 266264004550 oxyanion hole (OAH) forming residues; other site 266264004551 trimer interface [polypeptide binding]; other site 266264004552 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762 266264004553 substrate binding site [chemical binding]; other site 266264004554 oxyanion hole (OAH) forming residues; other site 266264004555 trimer interface [polypeptide binding]; other site 266264004556 anaerobic benzoate catabolism transcriptional regulator; Reviewed; Region: PRK08154 266264004557 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 266264004558 non-specific DNA binding site [nucleotide binding]; other site 266264004559 salt bridge; other site 266264004560 sequence-specific DNA binding site [nucleotide binding]; other site 266264004561 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 266264004562 ADP binding site [chemical binding]; other site 266264004563 magnesium binding site [ion binding]; other site 266264004564 putative shikimate binding site; other site 266264004565 benzoate-CoA ligase family; Region: benz_CoA_lig; TIGR02262 266264004566 Benzoate CoA ligase (BCL) and 4-Hydroxybenzoate-Coenzyme A Ligase (4-HBA-CoA ligase); Region: BCL_4HBCL; cd05959 266264004567 dimer interface [polypeptide binding]; other site 266264004568 acyl-activating enzyme (AAE) consensus motif; other site 266264004569 putative active site [active] 266264004570 putative AMP binding site [chemical binding]; other site 266264004571 putative CoA binding site [chemical binding]; other site 266264004572 chemical substrate binding site [chemical binding]; other site 266264004573 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 266264004574 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 266264004575 Type I periplasmic binding component of active transport systems that are predicted be involved in anaerobic biodegradation of alkylbenzenes such as toluene and ethylbenzene; Region: PBP1_alkylbenzenes_like; cd06360 266264004576 putative ligand binding site [chemical binding]; other site 266264004577 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 266264004578 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 266264004579 TM-ABC transporter signature motif; other site 266264004580 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 266264004581 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 266264004582 TM-ABC transporter signature motif; other site 266264004583 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 266264004584 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 266264004585 Walker A/P-loop; other site 266264004586 ATP binding site [chemical binding]; other site 266264004587 Q-loop/lid; other site 266264004588 ABC transporter signature motif; other site 266264004589 Walker B; other site 266264004590 D-loop; other site 266264004591 H-loop/switch region; other site 266264004592 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 266264004593 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 266264004594 Walker A/P-loop; other site 266264004595 ATP binding site [chemical binding]; other site 266264004596 Q-loop/lid; other site 266264004597 ABC transporter signature motif; other site 266264004598 Walker B; other site 266264004599 D-loop; other site 266264004600 H-loop/switch region; other site 266264004601 K+ transporter [Inorganic ion transport and metabolism]; Region: Kup; COG3158 266264004602 potassium uptake protein; Region: kup; TIGR00794 266264004603 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 266264004604 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 266264004605 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 266264004606 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 266264004607 RNA binding site [nucleotide binding]; other site 266264004608 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 266264004609 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 266264004610 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 266264004611 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 266264004612 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 266264004613 active site 266264004614 Int/Topo IB signature motif; other site 266264004615 DNA binding site [nucleotide binding] 266264004616 Protein of unknown function (DUF1016); Region: DUF1016; pfam06250 266264004617 Predicted nuclease of restriction endonuclease-like fold [General function prediction only]; Region: COG4804 266264004618 DNA repair protein RadC (part 1) 266264004619 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 266264004620 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235 266264004621 pAE1 and related integrases, DNA breaking-rejoining enzymes, integrase/recombinases, C-terminal domain. This CD includes various bacterial integrases, including the predicted integrase of the deletion-prone region of plasmid pAE1 of Alcaligenes eutrophus...; Region: INT_pAE1; cd01188 266264004622 Int/Topo IB signature motif; other site 266264004623 Site-specific recombinase XerC [DNA replication, recombination, and repair]; Region: XerC; COG4973 266264004624 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 266264004625 active site 266264004626 DNA binding site [nucleotide binding] 266264004627 Int/Topo IB signature motif; other site 266264004628 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 266264004629 INT_SG5, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 5, N- and C-terminal domains. The CD contains mainly predicted bacterial integrase/recombinases; Region: INT_SG5; cd01190 266264004630 Int/Topo IB signature motif; other site 266264004631 DNA repair protein(fragment; part 2) 266264004632 Domain of unknown function (DUF932); Region: DUF932; pfam06067 266264004633 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 266264004634 ParB-like nuclease domain; Region: ParBc; pfam02195 266264004635 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 266264004636 Coenzyme A binding pocket [chemical binding]; other site 266264004637 hypothetical protein 266264004638 Uncharacterized conserved protein [Function unknown]; Region: COG5489 266264004639 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 266264004640 non-specific DNA binding site [nucleotide binding]; other site 266264004641 salt bridge; other site 266264004642 sequence-specific DNA binding site [nucleotide binding]; other site 266264004643 Protein of unknown function (DUF2958); Region: DUF2958; pfam11171 266264004644 Winged helix-turn helix; Region: HTH_29; pfam13551 266264004645 Integrase core domain; Region: rve; pfam00665 266264004646 DDE domain; Region: DDE_Tnp_IS240; pfam13610 266264004647 Integrase core domain; Region: rve_3; pfam13683 266264004648 Uncharacterized conserved protein (DUF2285); Region: DUF2285; pfam10074 266264004649 Helix-turn-helix domain; Region: HTH_17; cl17695 266264004650 Replication initiator protein A; Region: RPA; pfam10134 266264004651 ParA-like protein; Provisional; Region: PHA02518 266264004652 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 266264004653 P-loop; other site 266264004654 Magnesium ion binding site [ion binding]; other site 266264004655 Protein of unknown function (DUF2840); Region: DUF2840; pfam11000 266264004656 conjugal transfer pilin processing protease TraF; Provisional; Region: PRK13838 266264004657 Signal peptidase, peptidase S26; Region: Peptidase_S26; pfam10502 266264004658 Type IV secretory pathway, VirD2 components (relaxase) [Intracellular trafficking and secretion]; Region: VirD2; COG3843 266264004659 Protein of unknown function (DUF3363); Region: DUF3363; pfam11843 266264004660 Cytochrome C' Region: Cytochrom_C_2; cl01610 266264004661 Uncharacterized protein conserved in bacteria (DUF2219); Region: DUF2219; pfam09982 266264004662 Transposase, Mutator family; Region: Transposase_mut; pfam00872 266264004663 MULE transposase domain; Region: MULE; pfam10551 266264004664 transposase/IS protein; Provisional; Region: PRK09183 266264004665 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 266264004666 Walker A motif; other site 266264004667 ATP binding site [chemical binding]; other site 266264004668 Walker B motif; other site 266264004669 arginine finger; other site 266264004670 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 266264004671 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 266264004672 DNA binding residues [nucleotide binding] 266264004673 Integrase core domain; Region: rve; pfam00665 266264004674 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 266264004675 Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236 266264004676 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 266264004677 Beta-Casp domain; Region: Beta-Casp; smart01027 266264004678 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 266264004679 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 266264004680 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 266264004681 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 266264004682 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 266264004683 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 266264004684 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 266264004685 transposase (fragment) 266264004686 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235 266264004687 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 266264004688 pAE1 and related integrases, DNA breaking-rejoining enzymes, integrase/recombinases, C-terminal domain. This CD includes various bacterial integrases, including the predicted integrase of the deletion-prone region of plasmid pAE1 of Alcaligenes eutrophus...; Region: INT_pAE1; cd01188 266264004689 Int/Topo IB signature motif; other site 266264004690 INT_SG4, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 4, N- and C-terminal domains. The CD contains mainly predicted bacterial integrase/recombinases for which not much biochemical characterization is available; Region: INT_SG4; cd01187 266264004691 Int/Topo IB signature motif; other site 266264004692 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 266264004693 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235 266264004694 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 266264004695 active site 266264004696 DNA binding site [nucleotide binding] 266264004697 Int/Topo IB signature motif; other site 266264004698 transposase (fragment)IS66 family 266264004699 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 266264004700 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 266264004701 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 266264004702 Walker B; other site 266264004703 D-loop; other site 266264004704 H-loop/switch region; other site 266264004705 transposase (fragment), with second part being Rmet_1304 266264004706 transposase, fragment of tnpB (Rmet_1302) 266264004707 Winged helix-turn helix; Region: HTH_29; pfam13551 266264004708 Integrase core domain; Region: rve; pfam00665 266264004709 DDE domain; Region: DDE_Tnp_IS240; pfam13610 266264004710 Integrase core domain; Region: rve_3; pfam13683 266264004711 HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis. HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197 266264004712 dimerization interface [polypeptide binding]; other site 266264004713 hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124 266264004714 ATP binding site [chemical binding]; other site 266264004715 hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062 266264004716 hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075 266264004717 HupF/HypC family; Region: HupF_HypC; pfam01455 266264004718 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068 266264004719 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 266264004720 Hydrogenase expression/synthesis hypA family; Region: HypA; cl17671 266264004721 Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375 266264004722 Protein of unknown function (DUF3457); Region: DUF3457; pfam11939 266264004723 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 266264004724 Rubredoxin; Region: Rubredoxin; pfam00301 266264004725 iron binding site [ion binding]; other site 266264004726 HupH hydrogenase expression protein, C-terminal conserved region; Region: HupH_C; pfam04809 266264004727 HupH hydrogenase expression protein, C-terminal conserved region; Region: HupH_C; pfam04809 266264004728 HyaE family; HyaE is also called HupG and HoxO. They are proteins serving a critical role in the assembly of multimeric [NiFe] hydrogenases, the enzymes that catalyze the oxidation of molecular hydrogen to enable microorganisms to utilize hydrogen as the...; Region: HyaE; cd02965 266264004729 HupF/HypC family; Region: HupF_HypC; pfam01455 266264004730 coenzyme F420-reducing hydrogenase delta subunit (putative coenzyme F420 hydrogenase processing subunit); Region: frhD; TIGR00130 266264004731 Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062 266264004732 putative substrate-binding site; other site 266264004733 nickel binding site [ion binding]; other site 266264004734 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 266264004735 Ni/Fe-hydrogenase, b-type cytochrome subunit; Region: CytB-hydogenase; TIGR02125 266264004736 HupE / UreJ protein; Region: HupE_UreJ; pfam04955 266264004737 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 266264004738 Nickel-dependent hydrogenase; Region: NiFeSe_Hases; pfam00374 266264004739 Ni,Fe-hydrogenase I small subunit [Energy production and conversion]; Region: HyaA; COG1740 266264004740 Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409 266264004741 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 266264004742 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 266264004743 Winged helix-turn helix; Region: HTH_29; pfam13551 266264004744 Integrase core domain; Region: rve; pfam00665 266264004745 DDE domain; Region: DDE_Tnp_IS240; pfam13610 266264004746 Integrase core domain; Region: rve_3; pfam13683 266264004747 IS3/IS407 family, partial tnpB, with second part being Rmet_1279 ((belongs to CMGI-2) 266264004748 Transposase; Region: HTH_Tnp_1; pfam01527 266264004749 putative insertion sequence transposase protein IS5 family, partial with second part being Rmet_1278 (belongs to CMGI-2) 266264004750 Activator of aromatic catabolism; Region: XylR_N; pfam06505 266264004751 V4R domain; Region: V4R; pfam02830 266264004752 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 266264004753 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 266264004754 Walker A motif; other site 266264004755 ATP binding site [chemical binding]; other site 266264004756 Walker B motif; other site 266264004757 arginine finger; other site 266264004758 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 266264004759 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase; Region: biphenyl_bphD; TIGR03343 266264004760 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 266264004761 Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; pfam03349 266264004762 Formaldehyde dehydrogenases; Region: FDH_like; cd05278 266264004763 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 266264004764 catalytic Zn binding site [ion binding]; other site 266264004765 NAD(P) binding site [chemical binding]; other site 266264004766 structural Zn binding site [ion binding]; other site 266264004767 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 266264004768 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 266264004769 glutathionine S-transferase (fragment) 266264004770 CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated; Region: PRK07609 266264004771 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 266264004772 catalytic loop [active] 266264004773 iron binding site [ion binding]; other site 266264004774 Toluene-4-monoxygenase electron transfer component of Pseudomonas mendocina hydroxylates toluene and forms p-cresol as part of a three component toluene-4-monoxygenase system. Electron transfer is from NADH to an NADH:ferredoxin oxidoreductase (TmoF in P; Region: T4MO_e_transfer_like; cd06190 266264004775 FAD binding pocket [chemical binding]; other site 266264004776 FAD binding motif [chemical binding]; other site 266264004777 phosphate binding motif [ion binding]; other site 266264004778 beta-alpha-beta structure motif; other site 266264004779 NAD binding pocket [chemical binding]; other site 266264004780 Aromatic and Alkene Monooxygenase Hydroxylase, subunit B, ferritin-like diiron-binding domain; Region: AAMH_B; cd01058 266264004781 dimerization interface [polypeptide binding]; other site 266264004782 MmoB/DmpM family; Region: MmoB_DmpM; pfam02406 266264004783 Toluene-4-monooxygenase effector protein complex (T4mo), Rieske ferredoxin subunit; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. T4mo is a four-protein complex that catalyzes the NADH- and O2-dependent...; Region: Rieske_T4moC; cd03474 266264004784 [2Fe-2S] cluster binding site [ion binding]; other site 266264004785 Toluene-4-monooxygenase system protein B (TmoB); Region: TmoB; pfam06234 266264004786 Aromatic and Alkene Monooxygenase Hydroxylase, subunit A, ferritin-like diiron-binding domain; Region: AAMH_A; cd01057 266264004787 dimerization interface [polypeptide binding]; other site 266264004788 putative path to active site cavity [active] 266264004789 diiron center [ion binding]; other site 266264004790 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cd00491 266264004791 active site 1 [active] 266264004792 dimer interface [polypeptide binding]; other site 266264004793 hexamer interface [polypeptide binding]; other site 266264004794 active site 2 [active] 266264004795 4-oxalocrotonate decarboxylase; Region: catechol_dmpH; TIGR03218 266264004796 4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase,; Validated; Region: PRK08195 266264004797 4-hydroxy-2-oxovalerate aldolase, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_HOA; cd07943 266264004798 active site 266264004799 catalytic residues [active] 266264004800 metal binding site [ion binding]; metal-binding site 266264004801 DmpG-like communication domain; Region: DmpG_comm; pfam07836 266264004802 acetaldehyde dehydrogenase; Validated; Region: PRK08300 266264004803 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 266264004804 Prokaryotic acetaldehyde dehydrogenase, dimerisation; Region: AcetDehyd-dimer; pfam09290 266264004805 2-oxopent-4-enoate hydratase; Region: catechol_dmpE; TIGR03220 266264004806 2-hydroxymuconic semialdehyde dehydrogenase; Region: OH_muco_semi_DH; TIGR03216 266264004807 Human aldehyde dehydrogenase family 8 member A1-like; Region: ALDH_F8_HMSADH; cd07093 266264004808 NAD binding site [chemical binding]; other site 266264004809 catalytic residues [active] 266264004810 Domain of unknown function (DUF336); Region: DUF336; pfam03928 266264004811 catechol 2,3 dioxygenase; Region: catechol_2_3; TIGR03211 266264004812 N-terminal domain of catechol 2,3-dioxygenase; Region: 2_3_CTD_N; cd07265 266264004813 tetramer interface [polypeptide binding]; other site 266264004814 C-terminal domain of catechol 2,3-dioxygenase; Region: 2_3_CTD_C; cd07243 266264004815 tetramer interface [polypeptide binding]; other site 266264004816 active site 266264004817 Fe binding site [ion binding]; other site 266264004818 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 266264004819 catalytic loop [active] 266264004820 iron binding site [ion binding]; other site 266264004821 CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated; Region: PRK07609 266264004822 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 266264004823 catalytic loop [active] 266264004824 iron binding site [ion binding]; other site 266264004825 Phenol 2-monooxygenase (phenol hydroxylase) is a flavoprotein monooxygenase, able to use molecular oxygen as a substrate in the microbial degredation of phenol. This protein is encoded by a single gene and uses a tightly bound FAD cofactor in the NAD(P)H...; Region: phenol_2-monooxygenase_like; cd06211 266264004826 FAD binding pocket [chemical binding]; other site 266264004827 FAD binding motif [chemical binding]; other site 266264004828 phosphate binding motif [ion binding]; other site 266264004829 beta-alpha-beta structure motif; other site 266264004830 NAD binding pocket [chemical binding]; other site 266264004831 Phenol hydroxylase conserved region; Region: Phenol_monoox; pfam04663 266264004832 Aromatic and Alkene Monooxygenase Hydroxylase, subunit A, ferritin-like diiron-binding domain; Region: AAMH_A; cd01057 266264004833 dimerization interface [polypeptide binding]; other site 266264004834 putative path to active site cavity [active] 266264004835 diiron center [ion binding]; other site 266264004836 MmoB/DmpM family; Region: MmoB_DmpM; pfam02406 266264004837 Aromatic and Alkene Monooxygenase Hydroxylase, subunit B, ferritin-like diiron-binding domain; Region: AAMH_B; cd01058 266264004838 dimerization interface [polypeptide binding]; other site 266264004839 Phenol hydroxylase subunit; Region: Phenol_hyd_sub; pfam06099 266264004840 conserved hypothetical protein (partial)(gene belongs to CMGI-2) 266264004841 acetoacetyl-CoA reductase; Region: AcAcCoA_reduct; TIGR01829 266264004842 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 266264004843 NAD(P) binding site [chemical binding]; other site 266264004844 homotetramer interface [polypeptide binding]; other site 266264004845 homodimer interface [polypeptide binding]; other site 266264004846 active site 266264004847 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 266264004848 Ligand Binding Site [chemical binding]; other site 266264004849 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 266264004850 classical (c) SDRs; Region: SDR_c; cd05233 266264004851 NAD(P) binding site [chemical binding]; other site 266264004852 active site 266264004853 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266264004854 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266264004855 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 266264004856 dimerization interface [polypeptide binding]; other site 266264004857 substrate binding pocket [chemical binding]; other site 266264004858 conjugal transfer coupling protein TraG; Provisional; Region: PRK13876 266264004859 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 266264004860 Walker A motif; other site 266264004861 ATP binding site [chemical binding]; other site 266264004862 Walker B motif; other site 266264004863 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 266264004864 P-type conjugative transfer ATPase TrbB; Region: TrbB_P; TIGR02782 266264004865 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 266264004866 ATP binding site [chemical binding]; other site 266264004867 Walker A motif; other site 266264004868 hexamer interface [polypeptide binding]; other site 266264004869 Walker B motif; other site 266264004870 TrbC/VIRB2 family; Region: TrbC; cl01583 266264004871 Type IV secretory pathway, TrbD component [Cell motility and secretion / Intracellular trafficking and secretion]; Region: TrbD; COG5268 266264004872 conjugal transfer ATPase TrbE; Provisional; Region: PRK13873 266264004873 CagE, TrbE, VirB family, component of type IV transporter system; Region: CagE_TrbE_VirB; pfam03135 266264004874 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 266264004875 Walker A motif; other site 266264004876 ATP binding site [chemical binding]; other site 266264004877 TraM recognition site of TraD and TraG; Region: TraG-D_C; cl17375 266264004878 conjugal transfer protein TrbJ; Provisional; Region: PRK13874 266264004879 Conjugal transfer/entry exclusion protein [Intracellular trafficking and secretion]; Region: COG5314 266264004880 conjugal transfer protein TrbL; Provisional; Region: PRK13875 266264004881 TrbL/VirB6 plasmid conjugal transfer protein; Region: TrbL; cl01503 266264004882 conjugal transfer protein TrbF; Provisional; Region: PRK13872 266264004883 VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cd06911 266264004884 VirB7 interaction site; other site 266264004885 Type IV secretory pathway, VirB10 components [Intracellular trafficking and secretion]; Region: VirB10; COG2948 266264004886 Protein of unknown function (DUF2274); Region: DUF2274; pfam10038 266264004887 outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302 266264004888 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 266264004889 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 266264004890 RNA binding surface [nucleotide binding]; other site 266264004891 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 266264004892 active site 266264004893 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 266264004894 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; cl00650 266264004895 poly(R)-hydroxyalkanoic acid synthase, class I; Region: PHA_synth_I; TIGR01838 266264004896 Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167 266264004897 putative acyltransferase; Provisional; Region: PRK05790 266264004898 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 266264004899 dimer interface [polypeptide binding]; other site 266264004900 active site 266264004901 acetyacetyl-CoA reductase; Provisional; Region: PRK12938 266264004902 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 266264004903 NAD(P) binding site [chemical binding]; other site 266264004904 homotetramer interface [polypeptide binding]; other site 266264004905 homodimer interface [polypeptide binding]; other site 266264004906 active site 266264004907 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5394 266264004908 PHB/PHA accumulation regulator DNA-binding domain; Region: PHB_acc_N; pfam07879 266264004909 PHB accumulation regulatory domain; Region: PHB_acc; pfam05233 266264004910 PHB accumulation regulatory domain; Region: PHB_acc; pfam05233 266264004911 ribosomal protein S12 methylthiotransferase; Provisional; Region: rimO; PRK14862 266264004912 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 266264004913 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 266264004914 FeS/SAM binding site; other site 266264004915 TRAM domain; Region: TRAM; cl01282 266264004916 beta-ketothiolase; Provisional; Region: PRK09051 266264004917 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 266264004918 dimer interface [polypeptide binding]; other site 266264004919 active site 266264004920 cystathionine beta-lyase; Provisional; Region: PRK07050 266264004921 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 266264004922 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 266264004923 catalytic residue [active] 266264004924 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 266264004925 PepSY-associated TM helix; Region: PepSY_TM_3; pfam13706 266264004926 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 266264004927 Domain of unknown function (DUF4072); Region: DUF4072; pfam13284 266264004928 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 266264004929 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 266264004930 motif II; other site 266264004931 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 266264004932 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 266264004933 substrate binding pocket [chemical binding]; other site 266264004934 membrane-bound complex binding site; other site 266264004935 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 266264004936 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 266264004937 substrate binding pocket [chemical binding]; other site 266264004938 membrane-bound complex binding site; other site 266264004939 hinge residues; other site 266264004940 alkanesulfonate monooxygenase; Provisional; Region: PRK00719 266264004941 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 266264004942 active site 266264004943 dimer interface [polypeptide binding]; other site 266264004944 non-prolyl cis peptide bond; other site 266264004945 insertion regions; other site 266264004946 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 266264004947 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266264004948 putative PBP binding loops; other site 266264004949 dimer interface [polypeptide binding]; other site 266264004950 ABC-ATPase subunit interface; other site 266264004951 aliphatic sulfonates transport ATP-binding subunit; Provisional; Region: ssuB; PRK11247 266264004952 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 266264004953 Walker A/P-loop; other site 266264004954 ATP binding site [chemical binding]; other site 266264004955 Q-loop/lid; other site 266264004956 ABC transporter signature motif; other site 266264004957 Walker B; other site 266264004958 D-loop; other site 266264004959 H-loop/switch region; other site 266264004960 EAL domain; Region: EAL; pfam00563 266264004961 Serine hydrolase; Region: Ser_hydrolase; pfam06821 266264004962 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 266264004963 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 266264004964 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266264004965 dimer interface [polypeptide binding]; other site 266264004966 conserved gate region; other site 266264004967 putative PBP binding loops; other site 266264004968 ABC-ATPase subunit interface; other site 266264004969 sulfate transport protein; Provisional; Region: cysT; CHL00187 266264004970 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266264004971 dimer interface [polypeptide binding]; other site 266264004972 conserved gate region; other site 266264004973 putative PBP binding loops; other site 266264004974 ABC-ATPase subunit interface; other site 266264004975 ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118 266264004976 ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296 266264004977 Walker A/P-loop; other site 266264004978 ATP binding site [chemical binding]; other site 266264004979 Q-loop/lid; other site 266264004980 ABC transporter signature motif; other site 266264004981 Walker B; other site 266264004982 D-loop; other site 266264004983 H-loop/switch region; other site 266264004984 TOBE-like domain; Region: TOBE_3; pfam12857 266264004985 transcriptional regulator CysB-like protein; Reviewed; Region: PRK12683 266264004986 The C-terminal substrate domain of LysR-type transcriptional regulators CysB-like contains type 2 periplasmic binding fold; Region: PBP2_CysB_like; cd08413 266264004987 substrate binding site [chemical binding]; other site 266264004988 dimerization interface [polypeptide binding]; other site 266264004989 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 266264004990 Histidine kinase; Region: His_kinase; pfam06580 266264004991 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266264004992 ATP binding site [chemical binding]; other site 266264004993 Mg2+ binding site [ion binding]; other site 266264004994 G-X-G motif; other site 266264004995 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 266264004996 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266264004997 active site 266264004998 phosphorylation site [posttranslational modification] 266264004999 intermolecular recognition site; other site 266264005000 dimerization interface [polypeptide binding]; other site 266264005001 LytTr DNA-binding domain; Region: LytTR; pfam04397 266264005002 ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372 266264005003 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 266264005004 putative active site pocket [active] 266264005005 dimerization interface [polypeptide binding]; other site 266264005006 putative catalytic residue [active] 266264005007 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 266264005008 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 266264005009 isocitrate lyase; Provisional; Region: PRK15063 266264005010 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 266264005011 tetramer interface [polypeptide binding]; other site 266264005012 active site 266264005013 Mg2+/Mn2+ binding site [ion binding]; other site 266264005014 Protein of unknown function (DUF3131); Region: DUF3131; pfam11329 266264005015 Putative glucoamylase; Region: Glycoamylase; pfam10091 266264005016 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 266264005017 Ligand Binding Site [chemical binding]; other site 266264005018 DNA-binding transcriptional regulator DsdC; Provisional; Region: PRK10086 266264005019 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266264005020 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 266264005021 putative effector binding pocket; other site 266264005022 dimerization interface [polypeptide binding]; other site 266264005023 2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428 266264005024 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 266264005025 motif II; other site 266264005026 malate synthase A; Region: malate_syn_A; TIGR01344 266264005027 Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727 266264005028 active site 266264005029 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 266264005030 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 266264005031 active site 266264005032 DUF1857, an uncharacterized ligand-binding domain of the SRPBCC domain superfamily; Region: SRPBCC_DUF1857; cd08863 266264005033 putative hydrophobic ligand binding site [chemical binding]; other site 266264005034 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266264005035 Major Facilitator Superfamily; Region: MFS_1; pfam07690 266264005036 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266264005037 Acyl CoA binding protein (ACBP) binds thiol esters of long fatty acids and coenzyme A in a one-to-one binding mode with high specificity and affinity. Acyl-CoAs are important intermediates in fatty lipid synthesis and fatty acid degradation and play a...; Region: ACBP; cl00221 266264005038 acyl-CoA binding pocket [chemical binding]; other site 266264005039 CoA binding site [chemical binding]; other site 266264005040 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 266264005041 Glycoprotease family; Region: Peptidase_M22; pfam00814 266264005042 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 266264005043 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 266264005044 Coenzyme A binding pocket [chemical binding]; other site 266264005045 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 266264005046 Fe-S cluster binding site [ion binding]; other site 266264005047 active site 266264005048 Domain of unknown function (DUF1853); Region: DUF1853; pfam08907 266264005049 lysophospholipid transporter LplT; Provisional; Region: PRK11195 266264005050 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266264005051 alanine racemase; Reviewed; Region: dadX; PRK03646 266264005052 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827 266264005053 active site 266264005054 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 266264005055 substrate binding site [chemical binding]; other site 266264005056 catalytic residues [active] 266264005057 dimer interface [polypeptide binding]; other site 266264005058 DNA repair protein RadA; Provisional; Region: PRK11823 266264005059 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 266264005060 Walker A motif/ATP binding site; other site 266264005061 ATP binding site [chemical binding]; other site 266264005062 Walker B motif; other site 266264005063 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 266264005064 disulfide bond formation protein B; Provisional; Region: PRK02110 266264005065 putative ABC transporter ATP-binding protein; Provisional; Region: PRK10636 266264005066 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 266264005067 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 266264005068 ABC transporter; Region: ABC_tran_2; pfam12848 266264005069 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 266264005070 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 266264005071 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 266264005072 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 266264005073 putative active site [active] 266264005074 Ntn-hydrolase superfamily, L-Asparaginase type 2-like enzymes. This family includes Glycosylasparaginase, Taspase 1 and L-Asparaginase type 2 enzymes. Glycosylasparaginase catalyzes the hydrolysis of the glycosylamide bond of asparagine-linked...; Region: Ntn_Asparaginase_2_like; cl00635 266264005075 L-Asparaginase type 2. L-Asparaginase hydrolyzes L-asparagine to L-aspartate and ammonia. The proenzyme undergoes an autoproteolytic cleavage into alpha and beta subunits to expose a threonine residue which becomes the N-terminal residue of the beta...; Region: Asparaginase_2; cd04701 266264005076 catalytic nucleophile [active] 266264005077 glutathione transporter ATP-binding protein; Provisional; Region: PRK10261 266264005078 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 266264005079 Walker A/P-loop; other site 266264005080 ATP binding site [chemical binding]; other site 266264005081 Q-loop/lid; other site 266264005082 ABC transporter signature motif; other site 266264005083 Walker B; other site 266264005084 D-loop; other site 266264005085 H-loop/switch region; other site 266264005086 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 266264005087 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 266264005088 Walker A/P-loop; other site 266264005089 ATP binding site [chemical binding]; other site 266264005090 Q-loop/lid; other site 266264005091 ABC transporter signature motif; other site 266264005092 Walker B; other site 266264005093 D-loop; other site 266264005094 H-loop/switch region; other site 266264005095 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 266264005096 The substrate-binding component of an uncharacterized ABC-type peptide import system Ylib contains the type 2 periplasmic binding fold; Region: PBP2_Ylib_like; cd08499 266264005097 glutathione ABC transporter substrate-binding protein GsiB; Provisional; Region: PRK15413 266264005098 glutathione ABC transporter permease GsiC; Provisional; Region: PRK15081 266264005099 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266264005100 dimer interface [polypeptide binding]; other site 266264005101 conserved gate region; other site 266264005102 putative PBP binding loops; other site 266264005103 ABC-ATPase subunit interface; other site 266264005104 glutathione ABC transporter permease GsiD; Provisional; Region: PRK15082 266264005105 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 266264005106 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266264005107 dimer interface [polypeptide binding]; other site 266264005108 conserved gate region; other site 266264005109 putative PBP binding loops; other site 266264005110 ABC-ATPase subunit interface; other site 266264005111 L-Aminopeptidase D-amidase/D-esterase (DmpA) family; DmpA catalyzes the release of N-terminal D and L amino acids from peptide susbtrates. DmpA is synthesized as a single polypeptide precursor, which is autocatalytically cleaved to the active...; Region: DmpA; cd02253 266264005112 homodimer interface [polypeptide binding]; other site 266264005113 homotetramer interface [polypeptide binding]; other site 266264005114 active site pocket [active] 266264005115 cleavage site 266264005116 Peptidase M55, D-aminopeptidase dipeptide-binding protein family; Region: DAP_dppA_1; cd08663 266264005117 SxDxEG motif; other site 266264005118 active site 266264005119 metal binding site [ion binding]; metal-binding site 266264005120 homopentamer interface [polypeptide binding]; other site 266264005121 Peptidase M14-like domain; uncharacterized subfamily; Region: M14-like_6; cd06233 266264005122 putative active site [active] 266264005123 Zn binding site [ion binding]; other site 266264005124 4-hydroxybenzoyl-CoA reductase, alpha subunit; Region: 4hydrxCoA_A; TIGR03194 266264005125 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; cl03161 266264005126 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 266264005127 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 266264005128 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 266264005129 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 266264005130 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 266264005131 Cytochrome c; Region: Cytochrom_C; cl11414 266264005132 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 266264005133 Cytochrome c; Region: Cytochrom_C; pfam00034 266264005134 Domain of unknown function (DUF3315); Region: DUF3315; pfam11776 266264005135 HemK family putative methylases; Region: hemK_fam; TIGR00536 266264005136 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 266264005137 S-adenosylmethionine binding site [chemical binding]; other site 266264005138 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009 266264005139 M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891 266264005140 metal binding site [ion binding]; metal-binding site 266264005141 dimer interface [polypeptide binding]; other site 266264005142 Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035 266264005143 ArsC family; Region: ArsC; pfam03960 266264005144 putative catalytic residues [active] 266264005145 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830 266264005146 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 266264005147 trimer interface [polypeptide binding]; other site 266264005148 active site 266264005149 substrate binding site [chemical binding]; other site 266264005150 CoA binding site [chemical binding]; other site 266264005151 succinyldiaminopimelate transaminase; Provisional; Region: PRK09147 266264005152 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 266264005153 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266264005154 homodimer interface [polypeptide binding]; other site 266264005155 catalytic residue [active] 266264005156 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 266264005157 dinuclear metal binding motif [ion binding]; other site 266264005158 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 266264005159 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 266264005160 Walker A/P-loop; other site 266264005161 ATP binding site [chemical binding]; other site 266264005162 Q-loop/lid; other site 266264005163 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 266264005164 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 266264005165 Q-loop/lid; other site 266264005166 ABC transporter signature motif; other site 266264005167 Walker B; other site 266264005168 D-loop; other site 266264005169 H-loop/switch region; other site 266264005170 ZipA, C-terminal domain (FtsZ-binding); Region: ZipA_C; smart00771 266264005171 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 266264005172 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 266264005173 nucleotide binding pocket [chemical binding]; other site 266264005174 K-X-D-G motif; other site 266264005175 catalytic site [active] 266264005176 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 266264005177 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 266264005178 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 266264005179 Dimer interface [polypeptide binding]; other site 266264005180 BRCT sequence motif; other site 266264005181 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 266264005182 active site 266264005183 catalytic residues [active] 266264005184 metal binding site [ion binding]; metal-binding site 266264005185 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266264005186 putative substrate translocation pore; other site 266264005187 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266264005188 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 266264005189 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 266264005190 non-specific DNA binding site [nucleotide binding]; other site 266264005191 salt bridge; other site 266264005192 sequence-specific DNA binding site [nucleotide binding]; other site 266264005193 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 266264005194 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 266264005195 RNA binding surface [nucleotide binding]; other site 266264005196 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 266264005197 active site 266264005198 PII uridylyl-transferase; Provisional; Region: PRK03059 266264005199 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 266264005200 metal binding triad; other site 266264005201 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 266264005202 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 266264005203 Zn2+ binding site [ion binding]; other site 266264005204 Mg2+ binding site [ion binding]; other site 266264005205 ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900 266264005206 C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899 266264005207 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 266264005208 active site 266264005209 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 266264005210 rRNA interaction site [nucleotide binding]; other site 266264005211 S8 interaction site; other site 266264005212 putative laminin-1 binding site; other site 266264005213 elongation factor Ts; Provisional; Region: tsf; PRK09377 266264005214 UBA/TS-N domain; Region: UBA; pfam00627 266264005215 Elongation factor TS; Region: EF_TS; pfam00889 266264005216 Elongation factor TS; Region: EF_TS; pfam00889 266264005217 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 266264005218 putative nucleotide binding site [chemical binding]; other site 266264005219 uridine monophosphate binding site [chemical binding]; other site 266264005220 homohexameric interface [polypeptide binding]; other site 266264005221 ribosome recycling factor; Reviewed; Region: frr; PRK00083 266264005222 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 266264005223 hinge region; other site 266264005224 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 266264005225 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 266264005226 catalytic residue [active] 266264005227 putative FPP diphosphate binding site; other site 266264005228 putative FPP binding hydrophobic cleft; other site 266264005229 dimer interface [polypeptide binding]; other site 266264005230 putative IPP diphosphate binding site; other site 266264005231 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 266264005232 CDP-diglyceride synthase; Provisional; Region: cdsA; PRK11624 266264005233 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 266264005234 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 266264005235 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 266264005236 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 266264005237 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 266264005238 zinc metallopeptidase RseP; Provisional; Region: PRK10779 266264005239 active site 266264005240 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 266264005241 protein binding site [polypeptide binding]; other site 266264005242 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 266264005243 outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303 266264005244 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 266264005245 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 266264005246 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 266264005247 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 266264005248 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 266264005249 Surface antigen; Region: Bac_surface_Ag; pfam01103 266264005250 Outer membrane protein (OmpH-like); Region: OmpH; smart00935 266264005251 periplasmic chaperone; Provisional; Region: PRK10780 266264005252 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 266264005253 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 266264005254 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 266264005255 trimer interface [polypeptide binding]; other site 266264005256 active site 266264005257 UDP-GlcNAc binding site [chemical binding]; other site 266264005258 lipid binding site [chemical binding]; lipid-binding site 266264005259 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 266264005260 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 266264005261 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 266264005262 active site 266264005263 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 266264005264 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 266264005265 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 266264005266 RNA/DNA hybrid binding site [nucleotide binding]; other site 266264005267 active site 266264005268 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 266264005269 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 266264005270 PEP synthetase regulatory protein; Provisional; Region: PRK05339 266264005271 phosphoenolpyruvate synthase; Validated; Region: PRK06464 266264005272 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 266264005273 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 266264005274 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 266264005275 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 266264005276 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 266264005277 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 266264005278 SmpB-tmRNA interface; other site 266264005279 Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813 266264005280 putative coenzyme Q binding site [chemical binding]; other site 266264005281 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2914 266264005282 Domain of unknown function (DUF4124); Region: DUF4124; pfam13511 266264005283 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 266264005284 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 266264005285 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 266264005286 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 266264005287 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 266264005288 active site 266264005289 GMP synthase; Reviewed; Region: guaA; PRK00074 266264005290 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 266264005291 AMP/PPi binding site [chemical binding]; other site 266264005292 candidate oxyanion hole; other site 266264005293 catalytic triad [active] 266264005294 potential glutamine specificity residues [chemical binding]; other site 266264005295 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 266264005296 ATP Binding subdomain [chemical binding]; other site 266264005297 Ligand Binding sites [chemical binding]; other site 266264005298 Dimerization subdomain; other site 266264005299 integrase; Provisional; Region: PRK09692 266264005300 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 266264005301 active site 266264005302 Int/Topo IB signature motif; other site 266264005303 Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; cl17523 266264005304 Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; pfam05930 266264005305 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 266264005306 active site 266264005307 Predicted P-loop ATPase [General function prediction only]; Region: COG4928 266264005308 KAP family P-loop domain; Region: KAP_NTPase; pfam07693 266264005309 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 266264005310 RT_Bac_retron_II: Reverse transcriptases (RTs) in bacterial retrotransposons or retrons. The polymerase reaction of this enzyme leads to the production of a unique RNA-DNA complex called msDNA (multicopy single-stranded (ss)DNA) in which a small ssDNA...; Region: RT_Bac_retron_II; cd03487 266264005311 putative active site [active] 266264005312 putative NTP binding site [chemical binding]; other site 266264005313 putative nucleic acid binding site [nucleotide binding]; other site 266264005314 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 266264005315 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 266264005316 non-specific DNA binding site [nucleotide binding]; other site 266264005317 salt bridge; other site 266264005318 sequence-specific DNA binding site [nucleotide binding]; other site 266264005319 Protein of unknown function (DUF2958); Region: DUF2958; pfam11171 266264005320 Domain of unknown function (DUF932); Region: DUF932; pfam06067 266264005321 ParB-like nuclease domain; Region: ParBc; pfam02195 266264005322 Uncharacterized conserved protein [Function unknown]; Region: COG5489 266264005323 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 266264005324 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 266264005325 non-specific DNA binding site [nucleotide binding]; other site 266264005326 salt bridge; other site 266264005327 sequence-specific DNA binding site [nucleotide binding]; other site 266264005328 Protein of unknown function (DUF2958); Region: DUF2958; pfam11171 266264005329 Uncharacterized conserved protein (DUF2285); Region: DUF2285; pfam10074 266264005330 Helix-turn-helix domain; Region: HTH_17; cl17695 266264005331 Replication initiator protein A; Region: RPA; pfam10134 266264005332 ParA-like protein; Provisional; Region: PHA02518 266264005333 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 266264005334 P-loop; other site 266264005335 Magnesium ion binding site [ion binding]; other site 266264005336 Protein of unknown function (DUF2840); Region: DUF2840; pfam11000 266264005337 conjugal transfer pilin processing protease TraF; Provisional; Region: PRK13838 266264005338 Signal peptidase, peptidase S26; Region: Peptidase_S26; pfam10502 266264005339 Type IV secretory pathway, VirD2 components (relaxase) [Intracellular trafficking and secretion]; Region: VirD2; COG3843 266264005340 Protein of unknown function (DUF3363); Region: DUF3363; pfam11843 266264005341 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 266264005342 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 266264005343 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 266264005344 Domain of unknown function (DUF4158); Region: DUF4158; pfam13700 266264005345 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; pfam01526 266264005346 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 266264005347 intersubunit interface [polypeptide binding]; other site 266264005348 active site 266264005349 zinc binding site [ion binding]; other site 266264005350 Na+ binding site [ion binding]; other site 266264005351 Ribosomal RNA small subunit methyltransferase B (rRNA (cytosine-C(5)-)-methyltransferase) (16S rRNA m5C967 methyltransferase) (fragment) 266264005352 conserved hypothetical protein with HAD-superfamily hydrolase domain (fragment) 266264005353 conserved hypothetical protein with HAD-superfamily hydrolase domain (fragment) 266264005354 norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial...; Region: vWA_norD_type; cd01454 266264005355 metal ion-dependent adhesion site (MIDAS); other site 266264005356 MoxR-like ATPases [General function prediction only]; Region: COG0714 266264005357 AAA domain (dynein-related subfamily); Region: AAA_5; pfam07728 266264005358 Walker A motif; other site 266264005359 ATP binding site [chemical binding]; other site 266264005360 Walker B motif; other site 266264005361 CbbQ/NirQ/NorQ C-terminal; Region: CbbQ_C; pfam08406 266264005362 Ribulose bisphosphate carboxylase/oxygenase (Rubisco), small subunit. Rubisco is a bifunctional enzyme catalyzes the initial steps of two opposing metabolic pathways: photosynthetic carbon fixation and the competing process of photorespiration. Rubisco...; Region: RuBisCO_small; cd03527 266264005363 multimerization interface [polypeptide binding]; other site 266264005364 ribulose bisophosphate carboxylase; Reviewed; Region: rbcL; PRK04208 266264005365 Ribulose bisphosphate carboxylase large chain; Region: RuBisCO_large; cl08232 266264005366 dimer interface [polypeptide binding]; other site 266264005367 catalytic residue [active] 266264005368 metal binding site [ion binding]; metal-binding site 266264005369 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266264005370 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266264005371 The C-terminal substrate binding of LysR-type transcriptional regulator (CbbR) of RubisCO operon, which is involved in the carbon dioxide fixation, contains the type 2 periplasmic binding fold; Region: PBP2_CbbR_RubisCO_like; cd08419 266264005372 putative dimerization interface [polypeptide binding]; other site 266264005373 Transposase, Mutator family; Region: Transposase_mut; pfam00872 266264005374 MULE transposase domain; Region: MULE; pfam10551 266264005375 transposase (part 2) IS1595 family 266264005376 transposase (part 1) 266264005377 Domain of unknown function (DUF4158); Region: DUF4158; pfam13700 266264005378 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; pfam01526 266264005379 Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354 266264005380 metal binding site [ion binding]; metal-binding site 266264005381 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266264005382 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266264005383 The C-terminal substrate binding of LysR-type transcriptional regulator (CbbR) of RubisCO operon, which is involved in the carbon dioxide fixation, contains the type 2 periplasmic binding fold; Region: PBP2_CbbR_RubisCO_like; cd08419 266264005384 putative dimerization interface [polypeptide binding]; other site 266264005385 hypothetical protein 266264005386 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 266264005387 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 266264005388 substrate binding site [chemical binding]; other site 266264005389 hexamer interface [polypeptide binding]; other site 266264005390 metal binding site [ion binding]; metal-binding site 266264005391 Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354 266264005392 AMP binding site [chemical binding]; other site 266264005393 metal binding site [ion binding]; metal-binding site 266264005394 active site 266264005395 phosphoribulokinase; Provisional; Region: PRK15453 266264005396 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 266264005397 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 266264005398 TPP-binding site [chemical binding]; other site 266264005399 dimer interface [polypeptide binding]; other site 266264005400 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 266264005401 PYR/PP interface [polypeptide binding]; other site 266264005402 dimer interface [polypeptide binding]; other site 266264005403 TPP binding site [chemical binding]; other site 266264005404 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 266264005405 phosphoglycolate phosphatase; Provisional; Region: PRK13222 266264005406 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 266264005407 motif II; other site 266264005408 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 266264005409 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 266264005410 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 266264005411 phosphoglycerate kinase; Provisional; Region: pgk; PRK00073 266264005412 Phosphoglycerate kinase; Region: PGK; pfam00162 266264005413 substrate binding site [chemical binding]; other site 266264005414 hinge regions; other site 266264005415 ADP binding site [chemical binding]; other site 266264005416 catalytic site [active] 266264005417 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 266264005418 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 266264005419 motif II; other site 266264005420 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 266264005421 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 266264005422 intersubunit interface [polypeptide binding]; other site 266264005423 active site 266264005424 zinc binding site [ion binding]; other site 266264005425 Na+ binding site [ion binding]; other site 266264005426 pyruvate kinase; Provisional; Region: PRK06247 266264005427 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 266264005428 domain interfaces; other site 266264005429 active site 266264005430 triosephosphate isomerase; Provisional; Region: PRK14567 266264005431 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 266264005432 substrate binding site [chemical binding]; other site 266264005433 dimer interface [polypeptide binding]; other site 266264005434 catalytic triad [active] 266264005435 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 266264005436 tetramer (dimer of dimers) interface [polypeptide binding]; other site 266264005437 active site 266264005438 dimer interface [polypeptide binding]; other site 266264005439 Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257 266264005440 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily, hoxF; composed of proteins similar to the NAD-reducing hydrogenase (hoxS) alpha subunit of Alcaligenes eutrophus H16. HoxS is a cytoplasmic hydrogenase...; Region: TRX_Fd_NuoE_hoxF; cd03083 266264005441 putative dimer interface [polypeptide binding]; other site 266264005442 NADH-quinone oxidoreductase, F subunit; Region: nuoF_fam; TIGR01959 266264005443 SLBB domain; Region: SLBB; pfam10531 266264005444 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 266264005445 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 266264005446 catalytic loop [active] 266264005447 iron binding site [ion binding]; other site 266264005448 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 266264005449 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 266264005450 Coenzyme F420-reducing hydrogenase, alpha subunit [Energy production and conversion]; Region: FrhA; COG3259 266264005451 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 266264005452 Endopeptidases that belong to the bidirectional NAD-linked hydrogenase group. This group of endopeptidases are highly specific carboxyl-terminal protease (HoxW protease) which releases a 24-amino-acid peptide from HoxH prior to progression of subunit...; Region: H2MP_NAD-link-bidir; cd06066 266264005453 nickel binding site [ion binding]; other site 266264005454 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 266264005455 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 266264005456 ligand binding site [chemical binding]; other site 266264005457 flexible hinge region; other site 266264005458 pyridine nucleotide transhydrogenase, alpha subunit (part 1) 266264005459 Helix-turn-helix domain; Region: HTH_38; pfam13936 266264005460 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 266264005461 Integrase core domain; Region: rve; pfam00665 266264005462 pyridine nucleotide transhydrogenase, alpha subunit (part 2) 266264005463 pyridine nucleotide transhydrogenase (proton pump), alpha subunit (fragment) 266264005464 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282 266264005465 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 266264005466 High-affinity nickel-transport protein; Region: NicO; cl00964 266264005467 putative hydrogenase expression/formation 266264005468 Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375 266264005469 Hydrogenase expression/synthesis hypA family; Region: HypA; pfam01155 266264005470 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 266264005471 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068 266264005472 Acylphosphatase; Region: Acylphosphatase; cl00551 266264005473 HypF finger; Region: zf-HYPF; pfam07503 266264005474 HypF finger; Region: zf-HYPF; pfam07503 266264005475 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 266264005476 HupF/HypC family; Region: HupF_HypC; pfam01455 266264005477 hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062 266264005478 hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075 266264005479 HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis. HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197 266264005480 dimerization interface [polypeptide binding]; other site 266264005481 hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124 266264005482 ATP binding site [chemical binding]; other site 266264005483 Methionyl-tRNA formyltransferase [Translation, ribosomal structure and biogenesis]; Region: Fmt; COG0223 266264005484 HypX protein, N-terminal hydrolase domain; Region: FMT_core_HypX_N; cd08650 266264005485 putative active site [active] 266264005486 putative substrate binding site [chemical binding]; other site 266264005487 putative cosubstrate binding site; other site 266264005488 catalytic site [active] 266264005489 C-terminal subdomain of the Formyltransferase-like domain found in HypX-like proteins; Region: FMT_C_HypX; cd08701 266264005490 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 266264005491 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 266264005492 substrate binding site [chemical binding]; other site 266264005493 oxyanion hole (OAH) forming residues; other site 266264005494 trimer interface [polypeptide binding]; other site 266264005495 Response regulator receiver domain; Region: Response_reg; pfam00072 266264005496 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266264005497 active site 266264005498 phosphorylation site [posttranslational modification] 266264005499 intermolecular recognition site; other site 266264005500 dimerization interface [polypeptide binding]; other site 266264005501 haloacid dehalogenase-like hydrolase family protein; Region: PLN02779 266264005502 Fragment of fructose-bisphosphate aldolase (cbbA) 266264005503 Domain of unknown function (DUF4158); Region: DUF4158; pfam13700 266264005504 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; pfam01526 266264005505 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266264005506 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266264005507 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 266264005508 dimerization interface [polypeptide binding]; other site 266264005509 substrate binding pocket [chemical binding]; other site 266264005510 conjugal transfer coupling protein TraG; Provisional; Region: PRK13876 266264005511 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 266264005512 Walker A motif; other site 266264005513 ATP binding site [chemical binding]; other site 266264005514 Walker B motif; other site 266264005515 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 266264005516 P-type conjugative transfer ATPase TrbB; Region: TrbB_P; TIGR02782 266264005517 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 266264005518 ATP binding site [chemical binding]; other site 266264005519 Walker A motif; other site 266264005520 hexamer interface [polypeptide binding]; other site 266264005521 Walker B motif; other site 266264005522 Type IV secretory pathway, VirB2 components (pilins) [Intracellular trafficking and secretion]; Region: VirB2; COG3838 266264005523 Type IV secretory pathway, TrbD component [Cell motility and secretion / Intracellular trafficking and secretion]; Region: TrbD; COG5268 266264005524 conjugal transfer ATPase TrbE; Provisional; Region: PRK13873 266264005525 CagE, TrbE, VirB family, component of type IV transporter system; Region: CagE_TrbE_VirB; pfam03135 266264005526 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 266264005527 Walker A motif; other site 266264005528 ATP binding site [chemical binding]; other site 266264005529 TraM recognition site of TraD and TraG; Region: TraG-D_C; cl17375 266264005530 conjugal transfer protein TrbJ; Provisional; Region: PRK13874 266264005531 Conjugal transfer/entry exclusion protein [Intracellular trafficking and secretion]; Region: COG5314 266264005532 conjugal transfer protein TrbL; Provisional; Region: PRK13875 266264005533 TrbL/VirB6 plasmid conjugal transfer protein; Region: TrbL; cl01503 266264005534 conjugal transfer protein TrbF; Provisional; Region: PRK13872 266264005535 VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cd06911 266264005536 VirB7 interaction site; other site 266264005537 Bacterial conjugation TrbI-like protein; Region: TrbI; cl04242 266264005538 Type IV secretory pathway, VirB10 components [Intracellular trafficking and secretion]; Region: VirB10; COG2948 266264005539 Protein of unknown function (DUF2274); Region: DUF2274; pfam10038 266264005540 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 266264005541 Protein of unknwon function (DUF2893); Region: DUF2893; pfam11459 266264005542 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843 266264005543 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 266264005544 Helix-turn-helix domain; Region: HTH_28; pfam13518 266264005545 Helix-turn-helix domain; Region: HTH_28; pfam13518 266264005546 putative transposase OrfB; Reviewed; Region: PHA02517 266264005547 HTH-like domain; Region: HTH_21; pfam13276 266264005548 Integrase core domain; Region: rve; pfam00665 266264005549 Integrase core domain; Region: rve_2; pfam13333 266264005550 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 266264005551 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 266264005552 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 266264005553 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 266264005554 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 266264005555 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 266264005556 PAS domain S-box; Region: sensory_box; TIGR00229 266264005557 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 266264005558 putative active site [active] 266264005559 heme pocket [chemical binding]; other site 266264005560 Uncharacterized protein conserved in bacteria (DUF2239); Region: DUF2239; pfam09998 266264005561 Domain of unknown function (DUF1993); Region: DUF1993; pfam09351 266264005562 Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602 266264005563 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 266264005564 FeS/SAM binding site; other site 266264005565 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 266264005566 active site 266264005567 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 266264005568 nucleoside/Zn binding site; other site 266264005569 dimer interface [polypeptide binding]; other site 266264005570 catalytic motif [active] 266264005571 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 266264005572 dimer interface [polypeptide binding]; other site 266264005573 catalytic triad [active] 266264005574 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 266264005575 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 266264005576 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 266264005577 ABC transporter; Region: ABC_tran_2; pfam12848 266264005578 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 266264005579 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like; Region: ALDH_CddD_SSP0762; cd07138 266264005580 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 266264005581 NAD binding site [chemical binding]; other site 266264005582 catalytic residues [active] 266264005583 Protein related to penicillin acylase [General function prediction only]; Region: COG2366 266264005584 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 266264005585 Penicillin G acylase (PGA) belongs to a family of beta-lactam acylases that includes cephalosporin acylase (CA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_PGA_like; cd03747 266264005586 active site 266264005587 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 266264005588 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 266264005589 catalytic triad [active] 266264005590 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 266264005591 MOSC domain; Region: MOSC; pfam03473 266264005592 3-alpha domain; Region: 3-alpha; pfam03475 266264005593 Predicted Fe-S protein [General function prediction only]; Region: COG3313 266264005594 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 266264005595 CoenzymeA binding site [chemical binding]; other site 266264005596 subunit interaction site [polypeptide binding]; other site 266264005597 PHB binding site; other site 266264005598 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 266264005599 active site 266264005600 homodimer interface [polypeptide binding]; other site 266264005601 homotetramer interface [polypeptide binding]; other site 266264005602 probable AcnD-accessory protein PrpF; Region: prpF; TIGR02334 266264005603 2-methylisocitrate dehydratase, Fe/S-dependent; Region: 2met_isocit_dHY; TIGR02333 266264005604 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 266264005605 substrate binding site [chemical binding]; other site 266264005606 ligand binding site [chemical binding]; other site 266264005607 Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215 266264005608 substrate binding site [chemical binding]; other site 266264005609 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 266264005610 Subgroup of Escherichia coli (Ec) 2-methylcitrate synthase (2MCS)_like. 2MCS catalyzes the condensation of propionyl-coenzyme A (PrCoA) and oxalacetate (OAA) to form 2-methylcitrate and coenzyme A (CoA) during propionate metabolism. Citrate synthase (CS)...; Region: Ec2MCS_like_1; cd06117 266264005611 dimer interface [polypeptide binding]; other site 266264005612 active site 266264005613 citrylCoA binding site [chemical binding]; other site 266264005614 oxalacetate/citrate binding site [chemical binding]; other site 266264005615 coenzyme A binding site [chemical binding]; other site 266264005616 catalytic triad [active] 266264005617 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 266264005618 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 266264005619 tetramer interface [polypeptide binding]; other site 266264005620 active site 266264005621 Mg2+/Mn2+ binding site [ion binding]; other site 266264005622 Propionate catabolism activator; Region: PrpR_N; pfam06506 266264005623 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 266264005624 PAS domain; Region: PAS; smart00091 266264005625 putative active site [active] 266264005626 heme pocket [chemical binding]; other site 266264005627 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 266264005628 Walker A motif; other site 266264005629 ATP binding site [chemical binding]; other site 266264005630 Walker B motif; other site 266264005631 arginine finger; other site 266264005632 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 266264005633 ergothioneine biosynthesis protein EgtB; Region: egtB_TIGR03440 266264005634 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 266264005635 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 266264005636 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 266264005637 transcriptional activator, LysR family (fragment) 266264005638 Helix-turn-helix domain; Region: HTH_38; pfam13936 266264005639 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 266264005640 Integrase core domain; Region: rve; pfam00665 266264005641 transcriptional regulator, LysR-family (fragment) 266264005642 DoxX; Region: DoxX; pfam07681 266264005643 Domain of unknown function (DUF4136); Region: DUF4136; pfam13590 266264005644 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 266264005645 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 266264005646 Cupin domain; Region: Cupin_2; pfam07883 266264005647 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 266264005648 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266264005649 dimer interface [polypeptide binding]; other site 266264005650 conserved gate region; other site 266264005651 putative PBP binding loops; other site 266264005652 ABC-ATPase subunit interface; other site 266264005653 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 266264005654 Cytochrome c; Region: Cytochrom_C; pfam00034 266264005655 MarR family; Region: MarR_2; cl17246 266264005656 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 266264005657 Surface antigen; Region: Bac_surface_Ag; pfam01103 266264005658 uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926 266264005659 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 266264005660 Cupin; Region: Cupin_6; pfam12852 266264005661 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 266264005662 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 266264005663 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266264005664 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266264005665 LysR substrate binding domain; Region: LysR_substrate; pfam03466 266264005666 dimerization interface [polypeptide binding]; other site 266264005667 LrgA family; Region: LrgA; pfam03788 266264005668 Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346 266264005669 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 266264005670 FAD binding domain; Region: FAD_binding_4; pfam01565 266264005671 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 266264005672 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266264005673 DNA-binding site [nucleotide binding]; DNA binding site 266264005674 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 266264005675 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266264005676 homodimer interface [polypeptide binding]; other site 266264005677 catalytic residue [active] 266264005678 acetylornithine deacetylase; Provisional; Region: PRK06837 266264005679 M20 Peptidases with similarity to acetylornithine deacetylases and succinyl-diaminopimelate desuccinylases; Region: M20_ArgE_DapE_like2; cd03895 266264005680 metal binding site [ion binding]; metal-binding site 266264005681 dimer interface [polypeptide binding]; other site 266264005682 putative extracellular solute-binding protein, family 5 (fragment) 266264005683 putative transposase OrfB; Reviewed; Region: PHA02517 266264005684 HTH-like domain; Region: HTH_21; pfam13276 266264005685 Integrase core domain; Region: rve; pfam00665 266264005686 Integrase core domain; Region: rve_3; pfam13683 266264005687 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 266264005688 Transposase; Region: HTH_Tnp_1; cl17663 266264005689 Putative solute-binding transport protein (Periplasmic) (fragment) 266264005690 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 266264005691 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266264005692 dimer interface [polypeptide binding]; other site 266264005693 conserved gate region; other site 266264005694 putative PBP binding loops; other site 266264005695 ABC-ATPase subunit interface; other site 266264005696 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 266264005697 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266264005698 dimer interface [polypeptide binding]; other site 266264005699 conserved gate region; other site 266264005700 putative PBP binding loops; other site 266264005701 ABC-ATPase subunit interface; other site 266264005702 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 266264005703 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 266264005704 Walker A/P-loop; other site 266264005705 ATP binding site [chemical binding]; other site 266264005706 Q-loop/lid; other site 266264005707 ABC transporter signature motif; other site 266264005708 Walker B; other site 266264005709 D-loop; other site 266264005710 H-loop/switch region; other site 266264005711 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 266264005712 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 266264005713 Walker A/P-loop; other site 266264005714 ATP binding site [chemical binding]; other site 266264005715 Q-loop/lid; other site 266264005716 ABC transporter signature motif; other site 266264005717 Walker B; other site 266264005718 D-loop; other site 266264005719 H-loop/switch region; other site 266264005720 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 266264005721 4-aminobutyrate aminotransferase; Provisional; Region: PRK06777 266264005722 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 266264005723 inhibitor-cofactor binding pocket; inhibition site 266264005724 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266264005725 catalytic residue [active] 266264005726 Cupin domain; Region: Cupin_2; cl17218 266264005727 thiamine pyrophosphate protein; Validated; Region: PRK08199 266264005728 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 266264005729 PYR/PP interface [polypeptide binding]; other site 266264005730 dimer interface [polypeptide binding]; other site 266264005731 TPP binding site [chemical binding]; other site 266264005732 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 266264005733 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 266264005734 TPP-binding site [chemical binding]; other site 266264005735 Histone deacetylase class IIa; Region: HDAC_classII_APAH; cd10001 266264005736 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 266264005737 active site 266264005738 Zn binding site [ion binding]; other site 266264005739 allantoate amidohydrolase; Reviewed; Region: PRK12893 266264005740 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 266264005741 active site 266264005742 metal binding site [ion binding]; metal-binding site 266264005743 dimer interface [polypeptide binding]; other site 266264005744 gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK09847 266264005745 Escherichia coli NADP+-dependent gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase PuuC-like; Region: ALDH_GABALDH-PuuC; cd07112 266264005746 NAD(P) binding site [chemical binding]; other site 266264005747 catalytic residues [active] 266264005748 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 266264005749 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266264005750 putative substrate translocation pore; other site 266264005751 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266264005752 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 266264005753 MarR family; Region: MarR; pfam01047 266264005754 Two-component sensor kinase N-terminal; Region: 2CSK_N; pfam08521 266264005755 HAMP domain; Region: HAMP; pfam00672 266264005756 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 266264005757 dimer interface [polypeptide binding]; other site 266264005758 phosphorylation site [posttranslational modification] 266264005759 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266264005760 ATP binding site [chemical binding]; other site 266264005761 Mg2+ binding site [ion binding]; other site 266264005762 G-X-G motif; other site 266264005763 transcriptional regulatory protein TctD; Provisional; Region: PRK15479 266264005764 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266264005765 active site 266264005766 phosphorylation site [posttranslational modification] 266264005767 intermolecular recognition site; other site 266264005768 dimerization interface [polypeptide binding]; other site 266264005769 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 266264005770 DNA binding site [nucleotide binding] 266264005771 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 266264005772 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 266264005773 trimer interface [polypeptide binding]; other site 266264005774 eyelet of channel; other site 266264005775 Uncharacterized conserved protein [Function unknown]; Region: COG3791 266264005776 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 266264005777 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 266264005778 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266264005779 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266264005780 The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433 266264005781 putative dimerization interface [polypeptide binding]; other site 266264005782 tartronate semialdehyde reductase; Provisional; Region: PRK15059 266264005783 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 266264005784 alpha-dehydro-beta-deoxy-D-glucarate aldolase; Provisional; Region: PRK10558 266264005785 putative dehydrogenase; Provisional; Region: PRK10098 266264005786 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 266264005787 thiamine pyrophosphate protein; Validated; Region: PRK08199 266264005788 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 266264005789 PYR/PP interface [polypeptide binding]; other site 266264005790 dimer interface [polypeptide binding]; other site 266264005791 TPP binding site [chemical binding]; other site 266264005792 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 266264005793 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 266264005794 TPP-binding site [chemical binding]; other site 266264005795 pyruvate carboxylase; Reviewed; Region: PRK12999 266264005796 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 266264005797 ATP-grasp domain; Region: ATP-grasp_4; cl17255 266264005798 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 266264005799 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 266264005800 active site 266264005801 catalytic residues [active] 266264005802 metal binding site [ion binding]; metal-binding site 266264005803 homodimer binding site [polypeptide binding]; other site 266264005804 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 266264005805 carboxyltransferase (CT) interaction site; other site 266264005806 biotinylation site [posttranslational modification]; other site 266264005807 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 266264005808 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 266264005809 trimer interface [polypeptide binding]; other site 266264005810 eyelet of channel; other site 266264005811 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 266264005812 Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327 266264005813 putative ligand binding site [chemical binding]; other site 266264005814 Putative cyclase; Region: Cyclase; pfam04199 266264005815 NUDIX domain; Region: NUDIX; pfam00293 266264005816 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 266264005817 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 266264005818 DNA polymerase II; Reviewed; Region: PRK05762 266264005819 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase II and similar bacterial family-B DNA polymerases; Region: DNA_polB_II_exo; cd05784 266264005820 active site 266264005821 catalytic site [active] 266264005822 substrate binding site [chemical binding]; other site 266264005823 DNA polymerase type-II subfamily catalytic domain. Bacteria contain five DNA polymerases (I, II, III, IV and V). DNA polymerase II (Pol II) is a prototype for the B-family of polymerases. The role of Pol II in a variety of cellular activities, such as...; Region: POLBc_Pol_II; cd05537 266264005824 active site 266264005825 metal-binding site 266264005826 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 266264005827 Mechanosensitive ion channel; Region: MS_channel; pfam00924 266264005828 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5343 266264005829 Anti-sigma-K factor rskA; Region: RskA; pfam10099 266264005830 RNA polymerase sigma factor; Provisional; Region: PRK12514 266264005831 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 266264005832 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 266264005833 DNA binding residues [nucleotide binding] 266264005834 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 266264005835 dinuclear metal binding motif [ion binding]; other site 266264005836 inner membrane protein; Provisional; Region: PRK11715 266264005837 sensory histidine kinase CreC; Provisional; Region: PRK11100 266264005838 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 266264005839 dimerization interface [polypeptide binding]; other site 266264005840 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 266264005841 dimer interface [polypeptide binding]; other site 266264005842 phosphorylation site [posttranslational modification] 266264005843 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266264005844 ATP binding site [chemical binding]; other site 266264005845 Mg2+ binding site [ion binding]; other site 266264005846 G-X-G motif; other site 266264005847 DNA-binding response regulator CreB; Provisional; Region: PRK11083 266264005848 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266264005849 active site 266264005850 phosphorylation site [posttranslational modification] 266264005851 intermolecular recognition site; other site 266264005852 dimerization interface [polypeptide binding]; other site 266264005853 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 266264005854 DNA binding site [nucleotide binding] 266264005855 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 266264005856 SmpA / OmlA family; Region: SmpA_OmlA; cl17115 266264005857 Outer membrane lipoprotein OmlA (small protein A) [Cell envelope biogenesis, outer membrane]; Region: OlmA; COG2913 266264005858 SmpA / OmlA family; Region: SmpA_OmlA; pfam04355 266264005859 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 266264005860 Transposase; Region: DDE_Tnp_ISL3; pfam01610 266264005861 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 266264005862 Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409 266264005863 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 266264005864 putative dimer interface [polypeptide binding]; other site 266264005865 N-terminal domain interface [polypeptide binding]; other site 266264005866 putative substrate binding pocket (H-site) [chemical binding]; other site 266264005867 Uncharacterized glycoside hydrolase family 99-like domain; Region: GH99_GH71_like_2; cd11576 266264005868 putative ligand binding site [chemical binding]; other site 266264005869 putative catalytic site [active] 266264005870 Plasmid encoded toxin Txe; Region: Plasmid_Txe; cl17389 266264005871 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 266264005872 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 266264005873 Integrase core domain; Region: rve; pfam00665 266264005874 hypothetical protein 266264005875 IS66-like transposase remnant 266264005876 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 266264005877 transposase remnant 266264005878 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 266264005879 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 266264005880 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 266264005881 Fimbrial protein; Region: Fimbrial; cl01416 266264005882 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 266264005883 PapC N-terminal domain; Region: PapC_N; pfam13954 266264005884 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 266264005885 PapC C-terminal domain; Region: PapC_C; pfam13953 266264005886 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 266264005887 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 266264005888 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 266264005889 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 266264005890 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 266264005891 Integrase core domain; Region: rve; pfam00665 266264005892 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 266264005893 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 266264005894 gamma-aminobutyrate permease; Region: GABAperm; TIGR01773 266264005895 poly(R)-hydroxyalkanoic acid synthase, class I; Region: PHA_synth_I; TIGR01838 266264005896 Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167 266264005897 (R)-hydratase [(R)-specific enoyl-CoA hydratase] catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. (R)-hydratase contains a hot-dog fold similar to those of thioesterase...; Region: R_hydratase; cd03449 266264005898 dimer interaction site [polypeptide binding]; other site 266264005899 substrate-binding tunnel; other site 266264005900 active site 266264005901 catalytic site [active] 266264005902 substrate binding site [chemical binding]; other site 266264005903 Predicted membrane protein (DUF2339); Region: DUF2339; pfam10101 266264005904 Protein of unknown function (DUF3999); Region: DUF3999; pfam13163 266264005905 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 266264005906 Ligand Binding Site [chemical binding]; other site 266264005907 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 266264005908 Ligand Binding Site [chemical binding]; other site 266264005909 phage integrase family protein (fragment) 266264005910 Uncharacterized protein conserved in bacteria (DUF2145); Region: DUF2145; pfam09916 266264005911 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 266264005912 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 266264005913 Major Facilitator Superfamily; Region: MFS_1; pfam07690 266264005914 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266264005915 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 266264005916 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 266264005917 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 266264005918 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 266264005919 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 266264005920 Walker A/P-loop; other site 266264005921 ATP binding site [chemical binding]; other site 266264005922 Q-loop/lid; other site 266264005923 ABC transporter signature motif; other site 266264005924 Walker B; other site 266264005925 D-loop; other site 266264005926 H-loop/switch region; other site 266264005927 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 266264005928 Walker A/P-loop; other site 266264005929 ATP binding site [chemical binding]; other site 266264005930 Q-loop/lid; other site 266264005931 ABC transporter signature motif; other site 266264005932 Walker B; other site 266264005933 D-loop; other site 266264005934 H-loop/switch region; other site 266264005935 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 266264005936 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 266264005937 putative efflux pump membrane fusion protein; Provisional; Region: PRK03598 266264005938 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 266264005939 HlyD family secretion protein; Region: HlyD_3; pfam13437 266264005940 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 266264005941 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 266264005942 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 266264005943 PAS domain; Region: PAS_9; pfam13426 266264005944 putative active site [active] 266264005945 heme pocket [chemical binding]; other site 266264005946 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 266264005947 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 266264005948 metal binding site [ion binding]; metal-binding site 266264005949 active site 266264005950 I-site; other site 266264005951 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 266264005952 hypothetical protein 266264005953 Flagellar transcriptional activator (FlhD); Region: FlhD; pfam05247 266264005954 Flagellar transcriptional activator (FlhC); Region: FlhC; pfam05280 266264005955 fumarate/nitrate reduction transcriptional regulator; Provisional; Region: PRK11161 266264005956 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 266264005957 ligand binding site [chemical binding]; other site 266264005958 flexible hinge region; other site 266264005959 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 266264005960 non-specific DNA interactions [nucleotide binding]; other site 266264005961 DNA binding site [nucleotide binding] 266264005962 sequence specific DNA binding site [nucleotide binding]; other site 266264005963 putative cAMP binding site [chemical binding]; other site 266264005964 hypothetical protein 266264005965 Tar ligand binding domain homologue; Region: TarH; pfam02203 266264005966 Protein of unknown function (DUF3300); Region: DUF3300; pfam11737 266264005967 Protein of unknown function (DUF2950); Region: DUF2950; pfam11453 266264005968 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 266264005969 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 266264005970 dimer interface [polypeptide binding]; other site 266264005971 phosphorylation site [posttranslational modification] 266264005972 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266264005973 ATP binding site [chemical binding]; other site 266264005974 G-X-G motif; other site 266264005975 Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566 266264005976 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266264005977 active site 266264005978 phosphorylation site [posttranslational modification] 266264005979 intermolecular recognition site; other site 266264005980 dimerization interface [polypeptide binding]; other site 266264005981 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 266264005982 DNA binding residues [nucleotide binding] 266264005983 dimerization interface [polypeptide binding]; other site 266264005984 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266264005985 Response regulator receiver domain; Region: Response_reg; pfam00072 266264005986 active site 266264005987 phosphorylation site [posttranslational modification] 266264005988 intermolecular recognition site; other site 266264005989 dimerization interface [polypeptide binding]; other site 266264005990 RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169 266264005991 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 266264005992 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 266264005993 HlyD family secretion protein; Region: HlyD_3; pfam13437 266264005994 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 266264005995 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 266264005996 polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707 266264005997 Domain of unknown function DUF20; Region: UPF0118; pfam01594 266264005998 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 266264005999 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 266264006000 multidrug resistance protein MdtN; Provisional; Region: PRK10476 266264006001 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 266264006002 HlyD family secretion protein; Region: HlyD_3; pfam13437 266264006003 Protein of unknown function (DUF2955); Region: DUF2955; pfam11168 266264006004 Ion channel; Region: Ion_trans_2; pfam07885 266264006005 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 266264006006 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 266264006007 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 266264006008 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 266264006009 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 266264006010 NADP binding site [chemical binding]; other site 266264006011 dimer interface [polypeptide binding]; other site 266264006012 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 266264006013 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 266264006014 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 266264006015 Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; Region: ttLC_FACS_AlkK_like; cd12119 266264006016 dimer interface [polypeptide binding]; other site 266264006017 acyl-activating enzyme (AAE) consensus motif; other site 266264006018 putative active site [active] 266264006019 AMP binding site [chemical binding]; other site 266264006020 putative CoA binding site [chemical binding]; other site 266264006021 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 266264006022 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 266264006023 Transcriptional regulator [Transcription]; Region: IclR; COG1414 266264006024 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 266264006025 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 266264006026 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 266264006027 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 266264006028 active site 266264006029 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 266264006030 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 266264006031 substrate binding site [chemical binding]; other site 266264006032 oxyanion hole (OAH) forming residues; other site 266264006033 trimer interface [polypeptide binding]; other site 266264006034 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 266264006035 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 266264006036 ATP-grasp domain; Region: ATP-grasp_4; cl17255 266264006037 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 266264006038 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 266264006039 carboxyltransferase (CT) interaction site; other site 266264006040 biotinylation site [posttranslational modification]; other site 266264006041 Protein of unknown function (DUF1446); Region: DUF1446; pfam07287 266264006042 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 266264006043 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 266264006044 CoA-transferase family III; Region: CoA_transf_3; pfam02515 266264006045 major facilitator superfamily (MFS) metabolite/H+ symporter (fragment) 266264006046 Protein of unknown function (DUF1289); Region: DUF1289; pfam06945 266264006047 Prokaryotic protein of unknown function (DUF849); Region: DUF849; pfam05853 266264006048 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 266264006049 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 266264006050 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 266264006051 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 266264006052 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 266264006053 trimer interface [polypeptide binding]; other site 266264006054 eyelet of channel; other site 266264006055 Serine hydrolase; Region: Ser_hydrolase; pfam06821 266264006056 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 266264006057 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266264006058 putative substrate translocation pore; other site 266264006059 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 266264006060 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 266264006061 CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421 266264006062 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 266264006063 DXD motif; other site 266264006064 PilZ domain; Region: PilZ; pfam07238 266264006065 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 266264006066 HlyD family secretion protein; Region: HlyD_3; pfam13437 266264006067 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 266264006068 Ligand Binding Site [chemical binding]; other site 266264006069 ergothioneine biosynthesis protein EgtC; Region: TIGR03442 266264006070 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 266264006071 putative active site [active] 266264006072 putative dimer interface [polypeptide binding]; other site 266264006073 Helix-turn-helix domain; Region: HTH_18; pfam12833 266264006074 AMP-binding domain protein; Validated; Region: PRK07529 266264006075 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 266264006076 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_4; cd05944 266264006077 acyl-activating enzyme (AAE) consensus motif; other site 266264006078 acyl-activating enzyme (AAE) consensus motif; other site 266264006079 putative AMP binding site [chemical binding]; other site 266264006080 putative active site [active] 266264006081 putative CoA binding site [chemical binding]; other site 266264006082 Protein of unknown function (DUF2726); Region: DUF2726; pfam10881 266264006083 AAA domain; Region: AAA_33; pfam13671 266264006084 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 266264006085 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 266264006086 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 266264006087 HlyD family secretion protein; Region: HlyD_3; pfam13437 266264006088 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 266264006089 heavy metal response regulator; Region: cztR_silR_copR; TIGR01387 266264006090 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266264006091 active site 266264006092 phosphorylation site [posttranslational modification] 266264006093 intermolecular recognition site; other site 266264006094 dimerization interface [polypeptide binding]; other site 266264006095 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 266264006096 DNA binding site [nucleotide binding] 266264006097 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 266264006098 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 266264006099 dimer interface [polypeptide binding]; other site 266264006100 phosphorylation site [posttranslational modification] 266264006101 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266264006102 ATP binding site [chemical binding]; other site 266264006103 Mg2+ binding site [ion binding]; other site 266264006104 G-X-G motif; other site 266264006105 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 266264006106 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 266264006107 CoA-transferase family III; Region: CoA_transf_3; pfam02515 266264006108 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266264006109 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266264006110 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 266264006111 putative effector binding pocket; other site 266264006112 dimerization interface [polypeptide binding]; other site 266264006113 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; cl01768 266264006114 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 266264006115 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 266264006116 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 266264006117 ABC transporter; Region: ABC_tran_2; pfam12848 266264006118 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 266264006119 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 266264006120 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 266264006121 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 266264006122 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 266264006123 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 266264006124 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 266264006125 Transporter associated domain; Region: CorC_HlyC; smart01091 266264006126 SnoaL-like domain; Region: SnoaL_2; pfam12680 266264006127 hypothetical protein 266264006128 Predicted dienelactone hydrolase [General function prediction only]; Region: COG4188 266264006129 Uncharacterized conserved protein [Function unknown]; Region: COG5649 266264006130 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 266264006131 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 266264006132 catalytic residue [active] 266264006133 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266264006134 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266264006135 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 266264006136 dimerization interface [polypeptide binding]; other site 266264006137 N-acetyl-gamma-glutamyl-phosphate reductase; Provisional; Region: PRK11863 266264006138 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 266264006139 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 266264006140 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 266264006141 Amidase; Region: Amidase; pfam01425 266264006142 Surface antigen [Cell envelope biogenesis, outer membrane]; Region: LipA; COG4520 266264006143 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 266264006144 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 266264006145 Coenzyme A binding pocket [chemical binding]; other site 266264006146 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_10; cd07251 266264006147 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 266264006148 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 266264006149 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266264006150 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 266264006151 dimerization interface [polypeptide binding]; other site 266264006152 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 266264006153 FAD binding domain; Region: FAD_binding_4; pfam01565 266264006154 Berberine and berberine like; Region: BBE; pfam08031 266264006155 beta-lactamase/D-alanine carboxypeptidase; Provisional; Region: ampC; PRK11289 266264006156 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 266264006157 Na/Pi-cotransporter; Region: NaPi_cotrn_rel; TIGR00704 266264006158 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 266264006159 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 266264006160 Bleomycin binding protein (BLMA) and similar proteins; BLMA confers bleomycin (Bm) resistance by directly binding to Bm; Region: BLMA_like; cd08349 266264006161 dimer interface [polypeptide binding]; other site 266264006162 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 266264006163 ligand binding site [chemical binding]; other site 266264006164 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 266264006165 S-adenosylmethionine binding site [chemical binding]; other site 266264006166 Catechol 1,2 dioxygenase (1,2-CTD) catalyzes an intradiol cleavage reaction of catechol to form cis,cis-muconate. 1,2-CTDs is homodimers with one catalytic non-heme ferric ion per monomer. They belong to the aromatic dioxygenase family, a family of...; Region: 1,2-CTD; cd03460 266264006167 catechol 1,2-dioxygenase, proteobacterial; Region: catechol_proteo; TIGR02439 266264006168 dimer interface [polypeptide binding]; other site 266264006169 active site 266264006170 CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated; Region: PRK07609 266264006171 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 266264006172 catalytic loop [active] 266264006173 iron binding site [ion binding]; other site 266264006174 Phenol 2-monooxygenase (phenol hydroxylase) is a flavoprotein monooxygenase, able to use molecular oxygen as a substrate in the microbial degredation of phenol. This protein is encoded by a single gene and uses a tightly bound FAD cofactor in the NAD(P)H...; Region: phenol_2-monooxygenase_like; cd06211 266264006175 FAD binding pocket [chemical binding]; other site 266264006176 FAD binding motif [chemical binding]; other site 266264006177 phosphate binding motif [ion binding]; other site 266264006178 beta-alpha-beta structure motif; other site 266264006179 NAD binding pocket [chemical binding]; other site 266264006180 Phenol hydroxylase conserved region; Region: Phenol_monoox; pfam04663 266264006181 Aromatic and Alkene Monooxygenase Hydroxylase, subunit A, ferritin-like diiron-binding domain; Region: AAMH_A; cd01057 266264006182 dimerization interface [polypeptide binding]; other site 266264006183 putative path to active site cavity [active] 266264006184 diiron center [ion binding]; other site 266264006185 MmoB/DmpM family; Region: MmoB_DmpM; pfam02406 266264006186 Aromatic and Alkene Monooxygenase Hydroxylase, subunit B, ferritin-like diiron-binding domain; Region: AAMH_B; cd01058 266264006187 dimerization interface [polypeptide binding]; other site 266264006188 Phenol hydroxylase subunit; Region: Phenol_hyd_sub; pfam06099 266264006189 Activator of aromatic catabolism; Region: XylR_N; pfam06505 266264006190 The V4R (vinyl 4 reductase) domain is a predicted small molecular binding domain, that may bind to hydrocarbons; Region: V4R; smart00989 266264006191 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 266264006192 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 266264006193 Walker A motif; other site 266264006194 ATP binding site [chemical binding]; other site 266264006195 Walker B motif; other site 266264006196 arginine finger; other site 266264006197 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 266264006198 Transcriptional regulators [Transcription]; Region: FadR; COG2186 266264006199 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266264006200 DNA-binding site [nucleotide binding]; DNA binding site 266264006201 FCD domain; Region: FCD; pfam07729 266264006202 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 266264006203 FAD binding domain; Region: FAD_binding_4; pfam01565 266264006204 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 266264006205 HlyD family secretion protein; Region: HlyD_3; pfam13437 266264006206 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 266264006207 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 266264006208 Walker A/P-loop; other site 266264006209 ATP binding site [chemical binding]; other site 266264006210 Q-loop/lid; other site 266264006211 ABC transporter signature motif; other site 266264006212 Walker B; other site 266264006213 D-loop; other site 266264006214 H-loop/switch region; other site 266264006215 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 266264006216 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 266264006217 FtsX-like permease family; Region: FtsX; pfam02687 266264006218 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 266264006219 FtsX-like permease family; Region: FtsX; pfam02687 266264006220 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 266264006221 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266264006222 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266264006223 The C-terminal substrate binding domain of LysR-like transcriptional regulator CidR, contains the type 2 periplasmic binding fold; Region: PBP2_CidR; cd08438 266264006224 putative dimerization interface [polypeptide binding]; other site 266264006225 Fusaric acid resistance protein family; Region: FUSC; pfam04632 266264006226 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 266264006227 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 266264006228 putative hydrophobic ligand binding site [chemical binding]; other site 266264006229 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_7; cd08900 266264006230 putative hydrophobic ligand binding site [chemical binding]; other site 266264006231 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 266264006232 dimerization interface [polypeptide binding]; other site 266264006233 putative DNA binding site [nucleotide binding]; other site 266264006234 putative Zn2+ binding site [ion binding]; other site 266264006235 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 266264006236 MarR family; Region: MarR_2; pfam12802 266264006237 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 266264006238 Sulfatase; Region: Sulfatase; cl17466 266264006239 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 266264006240 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 266264006241 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640 266264006242 putative membrane protein; Region: HpnL; TIGR03476 266264006243 Phosphocholine cytidylyltransferases catalyze the synthesis of CDP-choline; Region: PC_cytidylyltransferase; cd02523 266264006244 active site 266264006245 metal-binding site 266264006246 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 266264006247 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 266264006248 tetramer interface [polypeptide binding]; other site 266264006249 active site 266264006250 Mg2+/Mn2+ binding site [ion binding]; other site 266264006251 Phosphocholine cytidylyltransferases catalyze the synthesis of CDP-choline; Region: PC_cytidylyltransferase; cd02523 266264006252 active site 266264006253 metal-binding site 266264006254 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 266264006255 phosphonopyruvate decarboxylase; Region: Ppyr-DeCO2ase; TIGR03297 266264006256 PYR/PP interface [polypeptide binding]; other site 266264006257 dimer interface [polypeptide binding]; other site 266264006258 TPP binding site [chemical binding]; other site 266264006259 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 266264006260 TPP-binding site [chemical binding]; other site 266264006261 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 266264006262 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 266264006263 catalytic residue [active] 266264006264 Putative catalytic domain, repeat 1, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_1; cd09111 266264006265 putative active site [active] 266264006266 catalytic site [active] 266264006267 Putative catalytic domain, repeat 2, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_2; cd09113 266264006268 PLD-like domain; Region: PLDc_2; pfam13091 266264006269 putative active site [active] 266264006270 catalytic site [active] 266264006271 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 266264006272 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 266264006273 [2Fe-2S] cluster binding site [ion binding]; other site 266264006274 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 266264006275 hydrophobic ligand binding site; other site 266264006276 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 266264006277 CoA-transferase family III; Region: CoA_transf_3; pfam02515 266264006278 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 266264006279 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 266264006280 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 266264006281 active site 266264006282 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 266264006283 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 266264006284 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 266264006285 active site 266264006286 Transcriptional regulator [Transcription]; Region: IclR; COG1414 266264006287 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 266264006288 Bacterial transcriptional regulator; Region: IclR; pfam01614 266264006289 Transcriptional regulator [Transcription]; Region: IclR; COG1414 266264006290 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 266264006291 Bacterial transcriptional regulator; Region: IclR; pfam01614 266264006292 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 266264006293 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 266264006294 N-terminal plug; other site 266264006295 ligand-binding site [chemical binding]; other site 266264006296 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 266264006297 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 266264006298 ATP-grasp domain; Region: ATP-grasp; pfam02222 266264006299 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 266264006300 Mechanosensitive ion channel; Region: MS_channel; pfam00924 266264006301 Domain of unknown function (DUF3391); Region: DUF3391; pfam11871 266264006302 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 266264006303 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 266264006304 Zn2+ binding site [ion binding]; other site 266264006305 Mg2+ binding site [ion binding]; other site 266264006306 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 266264006307 DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]; Region: DnaJ; COG0484 266264006308 HSP70 interaction site [polypeptide binding]; other site 266264006309 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 266264006310 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 266264006311 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 266264006312 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 266264006313 active site 266264006314 PilZ domain; Region: PilZ; cl01260 266264006315 DNA polymerase III subunit delta'; Validated; Region: PRK06964 266264006316 DNA polymerase III subunit delta'; Validated; Region: PRK08485 266264006317 thymidylate kinase; Validated; Region: tmk; PRK00698 266264006318 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 266264006319 TMP-binding site; other site 266264006320 ATP-binding site [chemical binding]; other site 266264006321 YceG-like family; Region: YceG; pfam02618 266264006322 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 266264006323 dimerization interface [polypeptide binding]; other site 266264006324 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 266264006325 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 266264006326 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 266264006327 NRDE protein; Region: NRDE; cl01315 266264006328 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 266264006329 Coenzyme A binding pocket [chemical binding]; other site 266264006330 Transcriptional regulators [Transcription]; Region: FadR; COG2186 266264006331 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266264006332 DNA-binding site [nucleotide binding]; DNA binding site 266264006333 FCD domain; Region: FCD; pfam07729 266264006334 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 266264006335 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 266264006336 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395 266264006337 putative aldolase; Validated; Region: PRK08130 266264006338 intersubunit interface [polypeptide binding]; other site 266264006339 active site 266264006340 Zn2+ binding site [ion binding]; other site 266264006341 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 266264006342 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266264006343 putative substrate translocation pore; other site 266264006344 Hydroxypyruvate isomerase [Carbohydrate transport and metabolism]; Region: Hfi; COG3622 266264006345 Escherichia coli Gne (a nucleoside-diphosphate-sugar 4-epimerase)-like, extended (e) SDRs; Region: Gne_like_SDR_e; cd05238 266264006346 putative NAD(P) binding site [chemical binding]; other site 266264006347 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 266264006348 active site 266264006349 putative substrate binding site [chemical binding]; other site 266264006350 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 266264006351 active site 266264006352 Tripartite tricarboxylate transporter family receptor; Region: TctC; pfam03401 266264006353 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 266264006354 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 266264006355 substrate binding pocket [chemical binding]; other site 266264006356 Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908 266264006357 putative ADP-ribose binding site [chemical binding]; other site 266264006358 putative active site [active] 266264006359 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 266264006360 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 266264006361 hypothetical protein; Provisional; Region: PRK06194 266264006362 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266264006363 NAD(P) binding site [chemical binding]; other site 266264006364 active site 266264006365 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 266264006366 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 266264006367 C-terminal domain interface [polypeptide binding]; other site 266264006368 GSH binding site (G-site) [chemical binding]; other site 266264006369 dimer interface [polypeptide binding]; other site 266264006370 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 266264006371 N-terminal domain interface [polypeptide binding]; other site 266264006372 hypothetical protein; Provisional; Region: PRK06208 266264006373 intersubunit interface [polypeptide binding]; other site 266264006374 active site 266264006375 Zn2+ binding site [ion binding]; other site 266264006376 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 266264006377 Prostaglandin dehydrogenases; Region: PGDH; cd05288 266264006378 NAD(P) binding site [chemical binding]; other site 266264006379 substrate binding site [chemical binding]; other site 266264006380 dimer interface [polypeptide binding]; other site 266264006381 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 266264006382 CoenzymeA binding site [chemical binding]; other site 266264006383 subunit interaction site [polypeptide binding]; other site 266264006384 PHB binding site; other site 266264006385 gluconate 5-dehydrogenase; Provisional; Region: PRK08213 266264006386 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266264006387 NAD(P) binding site [chemical binding]; other site 266264006388 active site 266264006389 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 266264006390 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 266264006391 Putative acyl-CoA dehydrogenases similar to fadE5; Region: ACAD_fadE5; cd01153 266264006392 FAD binding site [chemical binding]; other site 266264006393 substrate binding site [chemical binding]; other site 266264006394 catalytic residues [active] 266264006395 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 266264006396 acetyl-CoA acetyltransferase; Provisional; Region: PRK07108 266264006397 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 266264006398 dimer interface [polypeptide binding]; other site 266264006399 active site 266264006400 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 266264006401 Isochorismatase family; Region: Isochorismatase; pfam00857 266264006402 catalytic triad [active] 266264006403 metal binding site [ion binding]; metal-binding site 266264006404 conserved cis-peptide bond; other site 266264006405 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 266264006406 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 266264006407 substrate binding site [chemical binding]; other site 266264006408 oxyanion hole (OAH) forming residues; other site 266264006409 trimer interface [polypeptide binding]; other site 266264006410 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 266264006411 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 266264006412 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 266264006413 lysine transporter; Provisional; Region: PRK10836 266264006414 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 266264006415 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 266264006416 Walker A/P-loop; other site 266264006417 ATP binding site [chemical binding]; other site 266264006418 Q-loop/lid; other site 266264006419 ABC transporter signature motif; other site 266264006420 Walker B; other site 266264006421 D-loop; other site 266264006422 H-loop/switch region; other site 266264006423 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 266264006424 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 266264006425 Walker A/P-loop; other site 266264006426 ATP binding site [chemical binding]; other site 266264006427 Q-loop/lid; other site 266264006428 ABC transporter signature motif; other site 266264006429 Walker B; other site 266264006430 D-loop; other site 266264006431 H-loop/switch region; other site 266264006432 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 266264006433 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 266264006434 TM-ABC transporter signature motif; other site 266264006435 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 266264006436 TM-ABC transporter signature motif; other site 266264006437 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 266264006438 Periplasmic solute-binding domain of active transport proteins; Region: PBP1_SBP_like_3; cd06329 266264006439 putative ligand binding site [chemical binding]; other site 266264006440 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07008 266264006441 Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; Region: ttLC_FACS_AlkK_like; cd12119 266264006442 dimer interface [polypeptide binding]; other site 266264006443 acyl-activating enzyme (AAE) consensus motif; other site 266264006444 putative active site [active] 266264006445 AMP binding site [chemical binding]; other site 266264006446 putative CoA binding site [chemical binding]; other site 266264006447 hypothetical protein; Validated; Region: PRK00029 266264006448 Uncharacterized conserved protein [Function unknown]; Region: COG0397 266264006449 methionine sulfoxide reductase B; Provisional; Region: PRK00222 266264006450 SelR domain; Region: SelR; pfam01641 266264006451 intracellular septation protein A; Reviewed; Region: PRK00259 266264006452 Stress-induced morphogen (activity unknown) [Signal transduction mechanisms]; Region: BolA; COG0271 266264006453 SurA N-terminal domain; Region: SurA_N_3; cl07813 266264006454 peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059 266264006455 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 266264006456 phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297 266264006457 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 266264006458 dimerization interface [polypeptide binding]; other site 266264006459 ATP binding site [chemical binding]; other site 266264006460 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 266264006461 dimerization interface [polypeptide binding]; other site 266264006462 ATP binding site [chemical binding]; other site 266264006463 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 266264006464 putative active site [active] 266264006465 catalytic triad [active] 266264006466 MarR family; Region: MarR_2; cl17246 266264006467 putative diguanylate cyclase YedQ; Provisional; Region: PRK15426 266264006468 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 266264006469 metal binding site [ion binding]; metal-binding site 266264006470 active site 266264006471 I-site; other site 266264006472 amidase; Provisional; Region: PRK07056 266264006473 Amidase; Region: Amidase; cl11426 266264006474 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 266264006475 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 266264006476 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290 266264006477 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274 266264006478 DctM-like transporters; Region: DctM; pfam06808 266264006479 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 266264006480 hydroxyglutarate oxidase; Provisional; Region: PRK11728 266264006481 Uncharacterized conserved protein [Function unknown]; Region: COG0062 266264006482 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 266264006483 putative substrate binding site [chemical binding]; other site 266264006484 putative ATP binding site [chemical binding]; other site 266264006485 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 266264006486 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 266264006487 active site 266264006488 dimer interface [polypeptide binding]; other site 266264006489 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 266264006490 dimer interface [polypeptide binding]; other site 266264006491 active site 266264006492 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 266264006493 Q-loop/lid; other site 266264006494 ABC transporter signature motif; other site 266264006495 Walker B; other site 266264006496 D-loop; other site 266264006497 H-loop/switch region; other site 266264006498 Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822 266264006499 active site 266264006500 catalytic triad [active] 266264006501 oxyanion hole [active] 266264006502 switch loop; other site 266264006503 SurA N-terminal domain; Region: SurA_N_3; cl07813 266264006504 periplasmic folding chaperone; Provisional; Region: PRK10788 266264006505 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 266264006506 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 266264006507 Found in ATP-dependent protease La (LON); Region: LON; smart00464 266264006508 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 266264006509 Walker A motif; other site 266264006510 ATP binding site [chemical binding]; other site 266264006511 Walker B motif; other site 266264006512 arginine finger; other site 266264006513 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 266264006514 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 266264006515 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 266264006516 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 266264006517 Walker A motif; other site 266264006518 ATP binding site [chemical binding]; other site 266264006519 Walker B motif; other site 266264006520 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 266264006521 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 266264006522 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 266264006523 oligomer interface [polypeptide binding]; other site 266264006524 active site residues [active] 266264006525 trigger factor; Provisional; Region: tig; PRK01490 266264006526 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 266264006527 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 266264006528 bifunctional tRNA (mnm(5)s(2)U34)-methyltransferase/FAD-dependent cmnm(5)s(2)U34 oxidoreductase; Reviewed; Region: mnmC; PRK01747 266264006529 Uncharacterized conserved protein [Function unknown]; Region: COG4121 266264006530 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 266264006531 Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961 266264006532 Catalytic domain of EDTA-resistant nuclease Nuc from Salmonella typhimurium and similar proteins; Region: PLDc_Nuc; cd09170 266264006533 PLD-like domain; Region: PLDc_2; pfam13091 266264006534 putative active site [active] 266264006535 catalytic site [active] 266264006536 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 266264006537 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 266264006538 DNA binding residues [nucleotide binding] 266264006539 dimerization interface [polypeptide binding]; other site 266264006540 Domain of unknown function (DUF1905); Region: DUF1905; pfam08922 266264006541 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 266264006542 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266264006543 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 266264006544 putative effector binding pocket; other site 266264006545 dimerization interface [polypeptide binding]; other site 266264006546 hypothetical protein; Validated; Region: PRK07586 266264006547 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 266264006548 PYR/PP interface [polypeptide binding]; other site 266264006549 dimer interface [polypeptide binding]; other site 266264006550 TPP binding site [chemical binding]; other site 266264006551 Thiamine pyrophosphate (TPP) family, BFDC subfamily, TPP-binding module; composed of proteins similar to Pseudomonas putida benzoylformate decarboxylase (BFDC). P. putida BFDC plays a role in the mandelate pathway, catalyzing the conversion of...; Region: TPP_BFDC; cd02002 266264006552 TPP-binding site [chemical binding]; other site 266264006553 dimer interface [polypeptide binding]; other site 266264006554 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 266264006555 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266264006556 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266264006557 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 266264006558 putative effector binding pocket; other site 266264006559 putative dimerization interface [polypeptide binding]; other site 266264006560 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like; Region: ALDH_CddD_SSP0762; cd07138 266264006561 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 266264006562 NAD binding site [chemical binding]; other site 266264006563 catalytic residues [active] 266264006564 pyruvate dehydrogenase; Provisional; Region: PRK09124 266264006565 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 266264006566 PYR/PP interface [polypeptide binding]; other site 266264006567 dimer interface [polypeptide binding]; other site 266264006568 tetramer interface [polypeptide binding]; other site 266264006569 TPP binding site [chemical binding]; other site 266264006570 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 266264006571 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 266264006572 TPP-binding site [chemical binding]; other site 266264006573 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 266264006574 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266264006575 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 266264006576 dimerization interface [polypeptide binding]; other site 266264006577 substrate binding pocket [chemical binding]; other site 266264006578 Helix-turn-helix XRE-family like proteins; Region: HTH_XRE; smart00530 266264006579 hypothetical protein; Provisional; Region: PRK11470 266264006580 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 266264006581 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 266264006582 Transcriptional regulators [Transcription]; Region: PurR; COG1609 266264006583 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 266264006584 DNA binding site [nucleotide binding] 266264006585 domain linker motif; other site 266264006586 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 266264006587 dimerization interface [polypeptide binding]; other site 266264006588 ligand binding site [chemical binding]; other site 266264006589 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 266264006590 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 266264006591 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 266264006592 trimer interface [polypeptide binding]; other site 266264006593 eyelet of channel; other site 266264006594 Cupin domain; Region: Cupin_2; pfam07883 266264006595 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 266264006596 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 266264006597 NAD(P) binding site [chemical binding]; other site 266264006598 Prokaryotic protein of unknown function (DUF849); Region: DUF849; pfam05853 266264006599 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase; Region: dhbA_paeA; TIGR04316 266264006600 classical (c) SDRs; Region: SDR_c; cd05233 266264006601 NAD(P) binding site [chemical binding]; other site 266264006602 active site 266264006603 Hydroxyquinol 1,2-dioxygenase (1,2-HQD) catalyzes the ring cleavage of hydroxyquinol (1,2,4-trihydroxybenzene), a intermediate in the degradation of a large variety of aromatic compounds including some polychloro- and nitroaromatic pollutants, to form...; Region: 1,2-HQD; cd03461 266264006604 catechol 1,2-dioxygenase, proteobacterial; Region: catechol_proteo; TIGR02439 266264006605 dimer interface [polypeptide binding]; other site 266264006606 active site 266264006607 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3224 266264006608 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 266264006609 Isochorismatase family; Region: Isochorismatase; pfam00857 266264006610 catalytic triad [active] 266264006611 dimer interface [polypeptide binding]; other site 266264006612 conserved cis-peptide bond; other site 266264006613 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266264006614 Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566 266264006615 active site 266264006616 dimerization interface [polypeptide binding]; other site 266264006617 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 266264006618 DNA binding residues [nucleotide binding] 266264006619 dimerization interface [polypeptide binding]; other site 266264006620 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 266264006621 dimer interface [polypeptide binding]; other site 266264006622 Isochorismatase family; Region: Isochorismatase; pfam00857 266264006623 catalytic triad [active] 266264006624 conserved cis-peptide bond; other site 266264006625 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 266264006626 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 266264006627 catalytic residues [active] 266264006628 Protein of unknown function (DUF1211); Region: DUF1211; cl01421 266264006629 Protein of unknown function (DUF1275); Region: DUF1275; pfam06912 266264006630 Isochorismatase family; Region: Isochorismatase; pfam00857 266264006631 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 266264006632 catalytic triad [active] 266264006633 dimer interface [polypeptide binding]; other site 266264006634 conserved cis-peptide bond; other site 266264006635 Zn-finger in ubiquitin-hydrolases and other protein; Region: zf-UBP; pfam02148 266264006636 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 266264006637 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 266264006638 ligand binding site [chemical binding]; other site 266264006639 flexible hinge region; other site 266264006640 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 266264006641 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 266264006642 OsmC-like protein; Region: OsmC; pfam02566 266264006643 short chain dehydrogenase; Provisional; Region: PRK07577 266264006644 classical (c) SDRs; Region: SDR_c; cd05233 266264006645 NAD(P) binding site [chemical binding]; other site 266264006646 active site 266264006647 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 266264006648 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266264006649 putative substrate translocation pore; other site 266264006650 amidase; Provisional; Region: PRK07056 266264006651 Amidase; Region: Amidase; cl11426 266264006652 Protein of unknown function (DUF2848); Region: DUF2848; pfam11010 266264006653 Transcriptional regulators [Transcription]; Region: GntR; COG1802 266264006654 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266264006655 DNA-binding site [nucleotide binding]; DNA binding site 266264006656 FCD domain; Region: FCD; pfam07729 266264006657 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 266264006658 Transcriptional regulator [Transcription]; Region: IclR; COG1414 266264006659 Bacterial transcriptional regulator; Region: IclR; pfam01614 266264006660 allantoate amidohydrolase; Reviewed; Region: PRK12893 266264006661 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 266264006662 active site 266264006663 metal binding site [ion binding]; metal-binding site 266264006664 dimer interface [polypeptide binding]; other site 266264006665 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 266264006666 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_8; cd08495 266264006667 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 266264006668 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266264006669 dimer interface [polypeptide binding]; other site 266264006670 conserved gate region; other site 266264006671 putative PBP binding loops; other site 266264006672 ABC-ATPase subunit interface; other site 266264006673 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 266264006674 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266264006675 dimer interface [polypeptide binding]; other site 266264006676 conserved gate region; other site 266264006677 putative PBP binding loops; other site 266264006678 ABC-ATPase subunit interface; other site 266264006679 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 266264006680 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 266264006681 Walker A/P-loop; other site 266264006682 ATP binding site [chemical binding]; other site 266264006683 Q-loop/lid; other site 266264006684 ABC transporter signature motif; other site 266264006685 Walker B; other site 266264006686 D-loop; other site 266264006687 H-loop/switch region; other site 266264006688 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 266264006689 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 266264006690 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 266264006691 Walker A/P-loop; other site 266264006692 ATP binding site [chemical binding]; other site 266264006693 Q-loop/lid; other site 266264006694 ABC transporter signature motif; other site 266264006695 Walker B; other site 266264006696 D-loop; other site 266264006697 H-loop/switch region; other site 266264006698 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 266264006699 amidase; Provisional; Region: PRK08310 266264006700 indole-3-acetamide amidohydrolase; Region: PLN02722 266264006701 Protein of unknown function (DUF3830); Region: DUF3830; pfam12903 266264006702 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266264006703 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266264006704 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 266264006705 dimerization interface [polypeptide binding]; other site 266264006706 substrate binding pocket [chemical binding]; other site 266264006707 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 266264006708 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 266264006709 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 266264006710 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 266264006711 HlyD family secretion protein; Region: HlyD_3; pfam13437 266264006712 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 266264006713 active site lid residues [active] 266264006714 substrate binding pocket [chemical binding]; other site 266264006715 catalytic residues [active] 266264006716 substrate-Mg2+ binding site; other site 266264006717 aspartate-rich region 1; other site 266264006718 aspartate-rich region 2; other site 266264006719 allantoate amidohydrolase; Reviewed; Region: PRK12893 266264006720 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 266264006721 active site 266264006722 metal binding site [ion binding]; metal-binding site 266264006723 dimer interface [polypeptide binding]; other site 266264006724 osmolarity response regulator; Provisional; Region: ompR; PRK09468 266264006725 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266264006726 active site 266264006727 phosphorylation site [posttranslational modification] 266264006728 intermolecular recognition site; other site 266264006729 dimerization interface [polypeptide binding]; other site 266264006730 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 266264006731 DNA binding site [nucleotide binding] 266264006732 osmolarity sensor protein; Provisional; Region: envZ; PRK09467 266264006733 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 266264006734 dimerization interface [polypeptide binding]; other site 266264006735 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266264006736 ATP binding site [chemical binding]; other site 266264006737 Mg2+ binding site [ion binding]; other site 266264006738 G-X-G motif; other site 266264006739 citrate-proton symporter; Provisional; Region: PRK15075 266264006740 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266264006741 putative substrate translocation pore; other site 266264006742 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 266264006743 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 266264006744 dimer interface [polypeptide binding]; other site 266264006745 decamer (pentamer of dimers) interface [polypeptide binding]; other site 266264006746 catalytic triad [active] 266264006747 peroxidatic and resolving cysteines [active] 266264006748 alkylhydroperoxidase, AhpD family; Region: ahpD; TIGR00777 266264006749 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 266264006750 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 266264006751 Coenzyme A binding pocket [chemical binding]; other site 266264006752 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 266264006753 homotrimer interaction site [polypeptide binding]; other site 266264006754 zinc binding site [ion binding]; other site 266264006755 CDP-binding sites; other site 266264006756 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 266264006757 substrate binding site; other site 266264006758 dimer interface; other site 266264006759 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 266264006760 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 266264006761 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 266264006762 ATP binding site [chemical binding]; other site 266264006763 putative Mg++ binding site [ion binding]; other site 266264006764 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 266264006765 nucleotide binding region [chemical binding]; other site 266264006766 ATP-binding site [chemical binding]; other site 266264006767 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 266264006768 acetylornithine deacetylase; Provisional; Region: PRK07522 266264006769 M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894 266264006770 metal binding site [ion binding]; metal-binding site 266264006771 putative dimer interface [polypeptide binding]; other site 266264006772 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 266264006773 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 266264006774 Organic hydroperoxide reductase [Secondary metabolites biosynthesis, transport and catabolism]; Region: osmC; COG1764 266264006775 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 266264006776 Clp amino terminal domain; Region: Clp_N; pfam02861 266264006777 Clp amino terminal domain; Region: Clp_N; pfam02861 266264006778 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 266264006779 Walker A motif; other site 266264006780 ATP binding site [chemical binding]; other site 266264006781 Walker B motif; other site 266264006782 arginine finger; other site 266264006783 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 266264006784 Walker A motif; other site 266264006785 ATP binding site [chemical binding]; other site 266264006786 Walker B motif; other site 266264006787 arginine finger; other site 266264006788 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 266264006789 3HB-oligomer hydrolase (3HBOH); Region: 3HBOH; pfam10605 266264006790 chromosome condensation membrane protein; Provisional; Region: PRK14196 266264006791 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 266264006792 MoaE homodimer interface [polypeptide binding]; other site 266264006793 MoaD interaction [polypeptide binding]; other site 266264006794 active site residues [active] 266264006795 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 266264006796 MoaE interaction surface [polypeptide binding]; other site 266264006797 MoeB interaction surface [polypeptide binding]; other site 266264006798 thiocarboxylated glycine; other site 266264006799 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 266264006800 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 266264006801 dimer interface [polypeptide binding]; other site 266264006802 putative functional site; other site 266264006803 putative MPT binding site; other site 266264006804 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 266264006805 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 266264006806 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266264006807 catalytic residue [active] 266264006808 homoserine dehydrogenase; Provisional; Region: PRK06349 266264006809 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 266264006810 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 266264006811 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 266264006812 aminotransferase AlaT; Validated; Region: PRK09265 266264006813 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 266264006814 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266264006815 homodimer interface [polypeptide binding]; other site 266264006816 catalytic residue [active] 266264006817 Xcc1710_like family, specific to proteobacteria. Xcc1710 is a hypothetical protein from Xanthomonas campestris pv. campestris str. ATCC 33913, similar to Mth938, a hypothetical protein encoded by the Methanobacterium thermoautotrophicum (Mth) genome; Region: Xcc1710_like; cd05560 266264006818 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 266264006819 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 266264006820 catalytic triad [active] 266264006821 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 266264006822 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 266264006823 putative active site [active] 266264006824 PhoH-like protein; Region: PhoH; pfam02562 266264006825 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 266264006826 NlpC/P60 family; Region: NLPC_P60; pfam00877 266264006827 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 266264006828 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 266264006829 replicative DNA helicase; Provisional; Region: PRK07004 266264006830 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 266264006831 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 266264006832 Walker A motif; other site 266264006833 ATP binding site [chemical binding]; other site 266264006834 Walker B motif; other site 266264006835 DNA binding loops [nucleotide binding] 266264006836 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 266264006837 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 266264006838 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 266264006839 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 266264006840 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 266264006841 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 266264006842 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 266264006843 active site 266264006844 homotetramer interface [polypeptide binding]; other site 266264006845 homodimer interface [polypeptide binding]; other site 266264006846 LexA repressor; Validated; Region: PRK00215 266264006847 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 266264006848 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 266264006849 Catalytic site [active] 266264006850 aspartate 4-decarboxylase; Region: asp_4_decarbox; TIGR03801 266264006851 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 266264006852 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266264006853 homodimer interface [polypeptide binding]; other site 266264006854 catalytic residue [active] 266264006855 aspartate-alanine antiporter; Region: Asp_Ala_antiprt; TIGR03802 266264006856 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 266264006857 TrkA-C domain; Region: TrkA_C; pfam02080 266264006858 TrkA-C domain; Region: TrkA_C; pfam02080 266264006859 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 266264006860 Protein of unknown function (DUF3079); Region: DUF3079; pfam11278 266264006861 tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815 266264006862 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 266264006863 FMN binding site [chemical binding]; other site 266264006864 active site 266264006865 catalytic residues [active] 266264006866 substrate binding site [chemical binding]; other site 266264006867 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 266264006868 Transposase; Region: HTH_Tnp_1; cl17663 266264006869 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 266264006870 insertion element IS2 transposase InsD; Provisional; Region: PRK14702 266264006871 HTH-like domain; Region: HTH_21; pfam13276 266264006872 Integrase core domain; Region: rve; pfam00665 266264006873 Integrase core domain; Region: rve_3; pfam13683 266264006874 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 266264006875 Phosphate-starvation-inducible E; Region: PsiE; pfam06146 266264006876 tyrosine-based site-specific recombinase (fragment) 266264006877 AAA domain; Region: AAA_22; pfam13401 266264006878 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 266264006879 Walker A motif; other site 266264006880 ATP binding site [chemical binding]; other site 266264006881 Walker B motif; other site 266264006882 arginine finger; other site 266264006883 Integrase core domain; Region: rve; pfam00665 266264006884 tyrosine-based site-specific recombinase(fragment) 266264006885 Helix-turn-helix domain; Region: HTH_17; cl17695 266264006886 Integrase core domain; Region: rve; pfam00665 266264006887 AAA domain; Region: AAA_22; pfam13401 266264006888 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 266264006889 Walker A motif; other site 266264006890 ATP binding site [chemical binding]; other site 266264006891 Walker B motif; other site 266264006892 arginine finger; other site 266264006893 phage head/capsid major protein(fragment) 266264006894 Protein of unknown function (DUF2971); Region: DUF2971; pfam11185 266264006895 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 266264006896 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cl17326 266264006897 putative DNA binding helix; other site 266264006898 Predicted flavoprotein [General function prediction only]; Region: COG0431 266264006899 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 266264006900 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 266264006901 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 266264006902 substrate binding site [chemical binding]; other site 266264006903 oxyanion hole (OAH) forming residues; other site 266264006904 trimer interface [polypeptide binding]; other site 266264006905 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 266264006906 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 266264006907 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 266264006908 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 266264006909 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 266264006910 G1 box; other site 266264006911 putative GEF interaction site [polypeptide binding]; other site 266264006912 GTP/Mg2+ binding site [chemical binding]; other site 266264006913 Switch I region; other site 266264006914 G2 box; other site 266264006915 G3 box; other site 266264006916 Switch II region; other site 266264006917 G4 box; other site 266264006918 G5 box; other site 266264006919 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 266264006920 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 266264006921 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 266264006922 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 266264006923 putative DNA binding site [nucleotide binding]; other site 266264006924 putative Zn2+ binding site [ion binding]; other site 266264006925 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 266264006926 multidrug efflux system protein EmrA; Provisional; Region: PRK15136 266264006927 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 266264006928 HlyD family secretion protein; Region: HlyD_3; pfam13437 266264006929 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 266264006930 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266264006931 putative substrate translocation pore; other site 266264006932 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266264006933 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK01851 266264006934 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 266264006935 RNA binding site [nucleotide binding]; other site 266264006936 active site 266264006937 Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157 266264006938 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 266264006939 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 266264006940 Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364 266264006941 translation initiation factor IF-2; Region: IF-2; TIGR00487 266264006942 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 266264006943 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 266264006944 G1 box; other site 266264006945 putative GEF interaction site [polypeptide binding]; other site 266264006946 GTP/Mg2+ binding site [chemical binding]; other site 266264006947 Switch I region; other site 266264006948 G2 box; other site 266264006949 G3 box; other site 266264006950 Switch II region; other site 266264006951 G4 box; other site 266264006952 G5 box; other site 266264006953 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 266264006954 Translation-initiation factor 2; Region: IF-2; pfam11987 266264006955 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 266264006956 transcription elongation factor NusA; Validated; Region: nusA; PRK09202 266264006957 NusA N-terminal domain; Region: NusA_N; pfam08529 266264006958 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 266264006959 RNA binding site [nucleotide binding]; other site 266264006960 homodimer interface [polypeptide binding]; other site 266264006961 NusA-like KH domain; Region: KH_5; pfam13184 266264006962 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 266264006963 G-X-X-G motif; other site 266264006964 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 266264006965 ribosome maturation protein RimP; Reviewed; Region: PRK00092 266264006966 Sm and related proteins; Region: Sm_like; cl00259 266264006967 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 266264006968 putative oligomer interface [polypeptide binding]; other site 266264006969 putative RNA binding site [nucleotide binding]; other site 266264006970 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 266264006971 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 266264006972 RNA binding surface [nucleotide binding]; other site 266264006973 Pseudouridine synthase, Escherichia coli RluB like; Region: PseudoU_synth_RluB; cd02556 266264006974 probable active site [active] 266264006975 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079 266264006976 Family description; Region: DsbD_2; pfam13386 266264006977 fumarate/nitrate reduction transcriptional regulator; Provisional; Region: PRK11161 266264006978 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 266264006979 ligand binding site [chemical binding]; other site 266264006980 flexible hinge region; other site 266264006981 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 266264006982 putative switch regulator; other site 266264006983 non-specific DNA interactions [nucleotide binding]; other site 266264006984 DNA binding site [nucleotide binding] 266264006985 sequence specific DNA binding site [nucleotide binding]; other site 266264006986 putative cAMP binding site [chemical binding]; other site 266264006987 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3198 266264006988 cytochrome c oxidase accessory protein FixG; Region: ccoG_rdxA_fixG; TIGR02745 266264006989 4Fe-4S binding domain; Region: Fer4_5; pfam12801 266264006990 Ubp3 associated protein Bre5; Region: Bre5; pfam11614 266264006991 cytochrome c oxidase, cbb3-type, subunit III; Region: ccoP; TIGR00782 266264006992 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 266264006993 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 266264006994 Cbb3-type cytochrome oxidase component FixQ; Region: FixQ; pfam05545 266264006995 Cbb3-type cytochrome oxidase, cytochrome c subunit [Energy production and conversion]; Region: CcoO; COG2993 266264006996 cbb3-type cytochrome c oxidase subunit II; Provisional; Region: PRK14487 266264006997 Cytochrome cbb3 oxidase subunit I. Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction...; Region: cbb3_Oxidase_I; cd01661 266264006998 Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115 266264006999 Low-spin heme binding site [chemical binding]; other site 266264007000 Putative water exit pathway; other site 266264007001 Binuclear center (active site) [active] 266264007002 Putative proton exit pathway; other site 266264007003 Uncharacterized protein, possibly involved in nitrogen fixation [Inorganic ion transport and metabolism]; Region: FixS; COG3197 266264007004 Putative metal-binding domain of cation transport ATPase; Region: ATPase-cat_bd; pfam12156 266264007005 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 266264007006 Heavy-metal-associated domain; Region: HMA; pfam00403 266264007007 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 266264007008 Soluble P-type ATPase [General function prediction only]; Region: COG4087 266264007009 Predicted ATPase [General function prediction only]; Region: COG1485 266264007010 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 266264007011 Walker B; other site 266264007012 D-loop; other site 266264007013 H-loop/switch region; other site 266264007014 dihydrolipoamide dehydrogenase; Validated; Region: PRK06327 266264007015 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 266264007016 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 266264007017 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 266264007018 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 266264007019 E3 interaction surface; other site 266264007020 lipoyl attachment site [posttranslational modification]; other site 266264007021 e3 binding domain; Region: E3_binding; pfam02817 266264007022 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 266264007023 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 266264007024 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 266264007025 TPP-binding site [chemical binding]; other site 266264007026 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 266264007027 cytoplasmic glycerophosphodiester phosphodiesterase; Provisional; Region: ugpQ; PRK09454 266264007028 Glycerophosphodiester phosphodiesterase domain in Escherichia coli cytosolic glycerophosphodiester phosphodiesterase UgpQ and similar proteins; Region: GDPD_EcUgpQ_like; cd08562 266264007029 putative active site [active] 266264007030 catalytic site [active] 266264007031 putative metal binding site [ion binding]; other site 266264007032 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 266264007033 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 266264007034 Walker A/P-loop; other site 266264007035 ATP binding site [chemical binding]; other site 266264007036 Q-loop/lid; other site 266264007037 ABC transporter signature motif; other site 266264007038 Walker B; other site 266264007039 D-loop; other site 266264007040 H-loop/switch region; other site 266264007041 TOBE domain; Region: TOBE_2; pfam08402 266264007042 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 266264007043 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266264007044 dimer interface [polypeptide binding]; other site 266264007045 conserved gate region; other site 266264007046 putative PBP binding loops; other site 266264007047 ABC-ATPase subunit interface; other site 266264007048 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 266264007049 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266264007050 dimer interface [polypeptide binding]; other site 266264007051 conserved gate region; other site 266264007052 putative PBP binding loops; other site 266264007053 ABC-ATPase subunit interface; other site 266264007054 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 266264007055 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 266264007056 HAD-superfamily hydrolase, subfamily IIB; Region: HAD-SF-IIB; TIGR01484 266264007057 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 266264007058 Peptidase M30; Region: Peptidase_M30; pfam10460 266264007059 nitrogen regulation protein NR(I); Region: ntrC; TIGR01818 266264007060 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266264007061 active site 266264007062 phosphorylation site [posttranslational modification] 266264007063 intermolecular recognition site; other site 266264007064 dimerization interface [polypeptide binding]; other site 266264007065 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 266264007066 Walker A motif; other site 266264007067 ATP binding site [chemical binding]; other site 266264007068 Walker B motif; other site 266264007069 arginine finger; other site 266264007070 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 266264007071 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 266264007072 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 266264007073 dimer interface [polypeptide binding]; other site 266264007074 phosphorylation site [posttranslational modification] 266264007075 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266264007076 ATP binding site [chemical binding]; other site 266264007077 Mg2+ binding site [ion binding]; other site 266264007078 G-X-G motif; other site 266264007079 glutamine synthetase; Provisional; Region: glnA; PRK09469 266264007080 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 266264007081 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 266264007082 Member of the Rhodanese Homology Domain superfamily, subgroup 1. This CD includes the putative rhodanese-related sulfurtransferases of several uncharacterized proteins; Region: RHOD_1; cd01522 266264007083 active site residue [active] 266264007084 Predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA [General function prediction only]; Region: CinA; COG1058 266264007085 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 266264007086 putative MPT binding site; other site 266264007087 Etoposide-induced protein 2.4 (EI24); Region: EI24; pfam07264 266264007088 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 266264007089 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 266264007090 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 266264007091 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 266264007092 NodB motif; other site 266264007093 active site 266264007094 catalytic site [active] 266264007095 metal binding site [ion binding]; metal-binding site 266264007096 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 266264007097 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 266264007098 ATP-dependent helicase HrpA; Region: DEAH_box_HrpA; TIGR01967 266264007099 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 266264007100 ATP binding site [chemical binding]; other site 266264007101 putative Mg++ binding site [ion binding]; other site 266264007102 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 266264007103 nucleotide binding region [chemical binding]; other site 266264007104 ATP-binding site [chemical binding]; other site 266264007105 Helicase associated domain (HA2); Region: HA2; pfam04408 266264007106 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 266264007107 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 266264007108 N-acetylglutamate synthase; Validated; Region: PRK05279 266264007109 AAK_NAGS-ABP: N-acetylglutamate (NAG) kinase-like domain of the NAG Synthase (NAGS) of the arginine-biosynthesis pathway (ABP) found in gamma- and beta-proteobacteria and higher plant chloroplasts. Domain architecture of these NAGS consisted of an...; Region: AAK_NAGS-ABP; cd04237 266264007110 putative feedback inhibition sensing region; other site 266264007111 putative nucleotide binding site [chemical binding]; other site 266264007112 putative substrate binding site [chemical binding]; other site 266264007113 N-acetylglutamate synthase and related acetyltransferases [Amino acid transport and metabolism]; Region: ArgA; COG1246 266264007114 oxidative damage protection protein; Provisional; Region: PRK05408 266264007115 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 266264007116 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266264007117 putative substrate translocation pore; other site 266264007118 nitrate/nitrite transport protein NarU; Provisional; Region: PRK15034 266264007119 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 266264007120 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 266264007121 [4Fe-4S] binding site [ion binding]; other site 266264007122 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 266264007123 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 266264007124 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 266264007125 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 266264007126 molybdopterin cofactor binding site; other site 266264007127 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 266264007128 Nitrate reductase delta subunit [Energy production and conversion]; Region: NarJ; COG2180 266264007129 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; pfam02665 266264007130 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884 266264007131 active site clefts [active] 266264007132 zinc binding site [ion binding]; other site 266264007133 dimer interface [polypeptide binding]; other site 266264007134 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 266264007135 Cytochrome D1 heme domain; Region: Cytochrom_D1; pfam02239 266264007136 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 266264007137 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 266264007138 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 266264007139 putative DNA binding site [nucleotide binding]; other site 266264007140 putative Zn2+ binding site [ion binding]; other site 266264007141 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 266264007142 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 266264007143 heme d1 biosynthesis radical SAM protein NirJ; Region: rSAM_NirJ; TIGR04051 266264007144 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377 266264007145 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 266264007146 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 266264007147 FMN binding site [chemical binding]; other site 266264007148 substrate binding site [chemical binding]; other site 266264007149 putative catalytic residue [active] 266264007150 Hemerythrin-like domain; Region: Hr-like; cd12108 266264007151 Signal transduction histidine kinase, nitrate/nitrite-specific [Signal transduction mechanisms]; Region: NarQ; COG3850 266264007152 Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675 266264007153 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 266264007154 dimerization interface [polypeptide binding]; other site 266264007155 GAF domain; Region: GAF; pfam01590 266264007156 Histidine kinase; Region: HisKA_3; pfam07730 266264007157 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266264007158 ATP binding site [chemical binding]; other site 266264007159 Mg2+ binding site [ion binding]; other site 266264007160 G-X-G motif; other site 266264007161 transcriptional regulator NarL; Provisional; Region: PRK10651 266264007162 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266264007163 active site 266264007164 phosphorylation site [posttranslational modification] 266264007165 intermolecular recognition site; other site 266264007166 dimerization interface [polypeptide binding]; other site 266264007167 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 266264007168 DNA binding residues [nucleotide binding] 266264007169 dimerization interface [polypeptide binding]; other site 266264007170 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 266264007171 tetramer (dimer of dimers) interface [polypeptide binding]; other site 266264007172 active site 266264007173 dimer interface [polypeptide binding]; other site 266264007174 transaldolase-like protein; Provisional; Region: PTZ00411 266264007175 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 266264007176 active site 266264007177 dimer interface [polypeptide binding]; other site 266264007178 catalytic residue [active] 266264007179 NAD-dependent deacetylase; Provisional; Region: PRK00481 266264007180 SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412 266264007181 NAD+ binding site [chemical binding]; other site 266264007182 substrate binding site [chemical binding]; other site 266264007183 Zn binding site [ion binding]; other site 266264007184 23S rRNA (guanosine-2'-O-)-methyltransferase; Provisional; Region: PRK11181 266264007185 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 266264007186 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 266264007187 ribonuclease R; Region: RNase_R; TIGR02063 266264007188 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 266264007189 RNB domain; Region: RNB; pfam00773 266264007190 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 266264007191 RNA binding site [nucleotide binding]; other site 266264007192 Predicted transcriptional regulator [Transcription]; Region: COG1959 266264007193 Transcriptional regulator; Region: Rrf2; pfam02082 266264007194 Transcriptional regulator; Region: Rrf2; cl17282 266264007195 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 266264007196 NADH(P)-binding; Region: NAD_binding_10; pfam13460 266264007197 NAD binding site [chemical binding]; other site 266264007198 putative active site [active] 266264007199 substrate binding site [chemical binding]; other site 266264007200 Predicted phosphoribosyltransferases [General function prediction only]; Region: COG2236 266264007201 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 266264007202 active site 266264007203 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 266264007204 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 266264007205 GDP-binding site [chemical binding]; other site 266264007206 ACT binding site; other site 266264007207 IMP binding site; other site 266264007208 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: PRK12421 266264007209 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 266264007210 dimer interface [polypeptide binding]; other site 266264007211 motif 1; other site 266264007212 active site 266264007213 motif 2; other site 266264007214 motif 3; other site 266264007215 HflC protein; Region: hflC; TIGR01932 266264007216 Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405 266264007217 Bacterial membrane protein N terminal; Region: HflK_N; pfam12221 266264007218 Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404 266264007219 HflK protein; Region: hflK; TIGR01933 266264007220 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 266264007221 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 266264007222 HflX GTPase family; Region: HflX; cd01878 266264007223 G1 box; other site 266264007224 GTP/Mg2+ binding site [chemical binding]; other site 266264007225 Switch I region; other site 266264007226 G2 box; other site 266264007227 G3 box; other site 266264007228 Switch II region; other site 266264007229 G4 box; other site 266264007230 G5 box; other site 266264007231 bacterial Hfq-like; Region: Hfq; cd01716 266264007232 hexamer interface [polypeptide binding]; other site 266264007233 Sm1 motif; other site 266264007234 RNA binding site [nucleotide binding]; other site 266264007235 Sm2 motif; other site 266264007236 GTP-binding protein Der; Reviewed; Region: PRK00093 266264007237 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 266264007238 G1 box; other site 266264007239 GTP/Mg2+ binding site [chemical binding]; other site 266264007240 Switch I region; other site 266264007241 G2 box; other site 266264007242 Switch II region; other site 266264007243 G3 box; other site 266264007244 G4 box; other site 266264007245 G5 box; other site 266264007246 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 266264007247 G1 box; other site 266264007248 GTP/Mg2+ binding site [chemical binding]; other site 266264007249 Switch I region; other site 266264007250 G2 box; other site 266264007251 G3 box; other site 266264007252 Switch II region; other site 266264007253 G4 box; other site 266264007254 G5 box; other site 266264007255 outer membrane assembly lipoprotein YfgL; Region: assembly_YfgL; TIGR03300 266264007256 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 266264007257 Trp docking motif [polypeptide binding]; other site 266264007258 active site 266264007259 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2976 266264007260 Uncharacterized protein conserved in bacteria (DUF2133); Region: DUF2133; pfam09976 266264007261 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 266264007262 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 266264007263 dimer interface [polypeptide binding]; other site 266264007264 motif 1; other site 266264007265 active site 266264007266 motif 2; other site 266264007267 motif 3; other site 266264007268 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 266264007269 anticodon binding site; other site 266264007270 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 266264007271 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 266264007272 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 266264007273 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 266264007274 non-specific DNA binding site [nucleotide binding]; other site 266264007275 salt bridge; other site 266264007276 sequence-specific DNA binding site [nucleotide binding]; other site 266264007277 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 266264007278 type IV pilus biogenesis/stability protein PilW; Region: type_IV_pilW; TIGR02521 266264007279 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 266264007280 binding surface 266264007281 TPR motif; other site 266264007282 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 266264007283 binding surface 266264007284 TPR motif; other site 266264007285 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK11194 266264007286 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 266264007287 FeS/SAM binding site; other site 266264007288 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 266264007289 active site 266264007290 multimer interface [polypeptide binding]; other site 266264007291 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 266264007292 YccA-like proteins; Region: YccA_like; cd10433 266264007293 23S rRNA m(5)U1939 methyltransferase; Reviewed; Region: rumA; PRK13168 266264007294 TRAM domain; Region: TRAM; cl01282 266264007295 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 266264007296 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 266264007297 S-adenosylmethionine binding site [chemical binding]; other site 266264007298 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 266264007299 putative catalytic site [active] 266264007300 putative metal binding site [ion binding]; other site 266264007301 putative phosphate binding site [ion binding]; other site 266264007302 Uncharacterized bacterial subgroup of the DEDDy 3'-5' exonuclease domain of family-B DNA polymerases; Region: DNA_polB_like1_exo; cd05782 266264007303 active site 266264007304 catalytic site [active] 266264007305 substrate binding site [chemical binding]; other site 266264007306 Predicted 3'-5' exonuclease related to the exonuclease domain of PolB; Region: DNA_pol_B_exo2; pfam10108 266264007307 RNA polymerase sigma factor RpoS; Region: rpoS_proteo; TIGR02394 266264007308 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 266264007309 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 266264007310 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 266264007311 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 266264007312 DNA binding residues [nucleotide binding] 266264007313 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 266264007314 Peptidase family M23; Region: Peptidase_M23; pfam01551 266264007315 Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518 266264007316 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 266264007317 S-adenosylmethionine binding site [chemical binding]; other site 266264007318 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 266264007319 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 266264007320 Quinone oxidoreductase (QOR); Region: QOR1; cd08241 266264007321 NAD(P) binding site [chemical binding]; other site 266264007322 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 266264007323 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266264007324 dimer interface [polypeptide binding]; other site 266264007325 conserved gate region; other site 266264007326 putative PBP binding loops; other site 266264007327 ABC-ATPase subunit interface; other site 266264007328 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 266264007329 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 266264007330 Walker A/P-loop; other site 266264007331 ATP binding site [chemical binding]; other site 266264007332 Q-loop/lid; other site 266264007333 ABC transporter signature motif; other site 266264007334 Walker B; other site 266264007335 D-loop; other site 266264007336 H-loop/switch region; other site 266264007337 NMT1-like family; Region: NMT1_2; pfam13379 266264007338 NMT1/THI5 like; Region: NMT1; pfam09084 266264007339 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 266264007340 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 266264007341 active site 266264007342 catalytic residues [active] 266264007343 metal binding site [ion binding]; metal-binding site 266264007344 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 266264007345 CoA-transferase family III; Region: CoA_transf_3; pfam02515 266264007346 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266264007347 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266264007348 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_1; cd08421 266264007349 putative dimerization interface [polypeptide binding]; other site 266264007350 recombination protein RecR; Reviewed; Region: recR; PRK00076 266264007351 RecR protein; Region: RecR; pfam02132 266264007352 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 266264007353 putative active site [active] 266264007354 putative metal-binding site [ion binding]; other site 266264007355 tetramer interface [polypeptide binding]; other site 266264007356 hypothetical protein; Validated; Region: PRK00153 266264007357 DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397 266264007358 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 266264007359 Walker A motif; other site 266264007360 ATP binding site [chemical binding]; other site 266264007361 Walker B motif; other site 266264007362 DNA polymerase III subunit delta'; Validated; Region: PRK08485 266264007363 arginine finger; other site 266264007364 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 266264007365 Ribonucleotide reductase, all-alpha domain; Region: Ribonuc_red_lgN; pfam00317 266264007366 ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent; Region: NrdJ_Z; TIGR02504 266264007367 Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888 266264007368 active site 266264007369 dimer interface [polypeptide binding]; other site 266264007370 effector binding site; other site 266264007371 Cys-rich peptide, TIGR04165 family; Region: methano_modCys 266264007372 ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains) [DNA replication, recombination, and repair]; Region: RecB; COG1074 266264007373 Family description; Region: UvrD_C_2; pfam13538 266264007374 Inactivated superfamily I helicase [DNA replication, recombination, and repair]; Region: COG3893 266264007375 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 266264007376 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 266264007377 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 266264007378 catalytic residues [active] 266264007379 transcription termination factor Rho; Provisional; Region: rho; PRK09376 266264007380 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 266264007381 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 266264007382 RNA binding site [nucleotide binding]; other site 266264007383 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 266264007384 multimer interface [polypeptide binding]; other site 266264007385 Walker A motif; other site 266264007386 ATP binding site [chemical binding]; other site 266264007387 Walker B motif; other site 266264007388 Phosphoenolpyruvate:glucose-phosphotransferase regulator; Region: MtfA; pfam06167 266264007389 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 266264007390 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 266264007391 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 266264007392 multidrug efflux protein; Reviewed; Region: PRK01766 266264007393 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 266264007394 cation binding site [ion binding]; other site 266264007395 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 266264007396 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 266264007397 HIGH motif; other site 266264007398 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 266264007399 active site 266264007400 KMSKS motif; other site 266264007401 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 266264007402 Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205 266264007403 nucleophile elbow; other site 266264007404 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 266264007405 NlpC/P60 family; Region: NLPC_P60; pfam00877 266264007406 ABC-type uncharacterized transport system, duplicated ATPase component [General function prediction only]; Region: COG4172 266264007407 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 266264007408 Walker A/P-loop; other site 266264007409 ATP binding site [chemical binding]; other site 266264007410 Q-loop/lid; other site 266264007411 ABC transporter signature motif; other site 266264007412 Walker B; other site 266264007413 D-loop; other site 266264007414 H-loop/switch region; other site 266264007415 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 266264007416 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 266264007417 Walker A/P-loop; other site 266264007418 ATP binding site [chemical binding]; other site 266264007419 Q-loop/lid; other site 266264007420 ABC transporter signature motif; other site 266264007421 Walker B; other site 266264007422 D-loop; other site 266264007423 H-loop/switch region; other site 266264007424 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4239 266264007425 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266264007426 dimer interface [polypeptide binding]; other site 266264007427 conserved gate region; other site 266264007428 putative PBP binding loops; other site 266264007429 ABC-ATPase subunit interface; other site 266264007430 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4174 266264007431 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266264007432 dimer interface [polypeptide binding]; other site 266264007433 conserved gate region; other site 266264007434 putative PBP binding loops; other site 266264007435 ABC-ATPase subunit interface; other site 266264007436 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 266264007437 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 266264007438 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 266264007439 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK06997 266264007440 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 266264007441 NAD binding site [chemical binding]; other site 266264007442 homotetramer interface [polypeptide binding]; other site 266264007443 homodimer interface [polypeptide binding]; other site 266264007444 substrate binding site [chemical binding]; other site 266264007445 active site 266264007446 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266264007447 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266264007448 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 266264007449 dimerization interface [polypeptide binding]; other site 266264007450 Alkyl sulfatase and related hydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2015 266264007451 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 266264007452 SCP-2 sterol transfer family; Region: SCP2; pfam02036 266264007453 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 266264007454 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 266264007455 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 266264007456 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 266264007457 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 266264007458 Transglycosylase; Region: Transgly; pfam00912 266264007459 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 266264007460 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 266264007461 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266264007462 active site 266264007463 phosphorylation site [posttranslational modification] 266264007464 intermolecular recognition site; other site 266264007465 dimerization interface [polypeptide binding]; other site 266264007466 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 266264007467 DNA binding residues [nucleotide binding] 266264007468 dimerization interface [polypeptide binding]; other site 266264007469 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 266264007470 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 266264007471 substrate binding pocket [chemical binding]; other site 266264007472 membrane-bound complex binding site; other site 266264007473 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 266264007474 hinge residues; other site 266264007475 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 266264007476 dimer interface [polypeptide binding]; other site 266264007477 phosphorylation site [posttranslational modification] 266264007478 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266264007479 ATP binding site [chemical binding]; other site 266264007480 Mg2+ binding site [ion binding]; other site 266264007481 G-X-G motif; other site 266264007482 Response regulator receiver domain; Region: Response_reg; pfam00072 266264007483 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266264007484 active site 266264007485 phosphorylation site [posttranslational modification] 266264007486 intermolecular recognition site; other site 266264007487 dimerization interface [polypeptide binding]; other site 266264007488 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 266264007489 Cytochrome c; Region: Cytochrom_C; pfam00034 266264007490 Cytochrome c [Energy production and conversion]; Region: COG3258 266264007491 Cytochrome c; Region: Cytochrom_C; pfam00034 266264007492 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 266264007493 sequence-specific DNA binding site [nucleotide binding]; other site 266264007494 salt bridge; other site 266264007495 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 266264007496 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 266264007497 non-specific DNA binding site [nucleotide binding]; other site 266264007498 salt bridge; other site 266264007499 sequence-specific DNA binding site [nucleotide binding]; other site 266264007500 Piwi_piwi-like_ProArk: PIWI domain, Piwi-like subfamily found in Archaea and Bacteria. RNA silencing refers to a group of related gene-silencing mechanisms mediated by short RNA molecules, including siRNAs, miRNAs, and heterochromatin-related guide RNAs; Region: Piwi_piwi-like_ProArk; cd04659 266264007501 5' RNA guide strand anchoring site; other site 266264007502 active site 266264007503 Domain of unknown function (DUF4365); Region: DUF4365; pfam14280 266264007504 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 266264007505 non-specific DNA binding site [nucleotide binding]; other site 266264007506 salt bridge; other site 266264007507 sequence-specific DNA binding site [nucleotide binding]; other site 266264007508 Predicted P-loop ATPase [General function prediction only]; Region: COG4928 266264007509 KAP family P-loop domain; Region: KAP_NTPase; pfam07693 266264007510 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 266264007511 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 266264007512 active site 266264007513 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 266264007514 active site 266264007515 catalytic residues [active] 266264007516 DNA binding site [nucleotide binding] 266264007517 Int/Topo IB signature motif; other site 266264007518 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 266264007519 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 266264007520 metal binding site [ion binding]; metal-binding site 266264007521 active site 266264007522 I-site; other site 266264007523 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 266264007524 rRNA binding site [nucleotide binding]; other site 266264007525 predicted 30S ribosome binding site; other site 266264007526 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 266264007527 catalytic core [active] 266264007528 Putative hemolysin [General function prediction only]; Region: COG3176 266264007529 Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248 266264007530 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 266264007531 polyphosphate kinase; Provisional; Region: PRK05443 266264007532 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 266264007533 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 266264007534 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 266264007535 putative active site [active] 266264007536 catalytic site [active] 266264007537 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 266264007538 putative domain interface [polypeptide binding]; other site 266264007539 putative active site [active] 266264007540 catalytic site [active] 266264007541 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 266264007542 PAS domain; Region: PAS; smart00091 266264007543 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 266264007544 dimer interface [polypeptide binding]; other site 266264007545 phosphorylation site [posttranslational modification] 266264007546 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266264007547 ATP binding site [chemical binding]; other site 266264007548 Mg2+ binding site [ion binding]; other site 266264007549 G-X-G motif; other site 266264007550 phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154 266264007551 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266264007552 active site 266264007553 phosphorylation site [posttranslational modification] 266264007554 intermolecular recognition site; other site 266264007555 dimerization interface [polypeptide binding]; other site 266264007556 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 266264007557 DNA binding site [nucleotide binding] 266264007558 transcriptional regulator PhoU; Provisional; Region: PRK11115 266264007559 PhoU domain; Region: PhoU; pfam01895 266264007560 PhoU domain; Region: PhoU; pfam01895 266264007561 phosphate transporter ATP-binding protein; Provisional; Region: pstB; PRK10744 266264007562 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 266264007563 Walker A/P-loop; other site 266264007564 ATP binding site [chemical binding]; other site 266264007565 Q-loop/lid; other site 266264007566 ABC transporter signature motif; other site 266264007567 Walker B; other site 266264007568 D-loop; other site 266264007569 H-loop/switch region; other site 266264007570 phosphate transporter permease subunit PtsA; Provisional; Region: pstA; PRK11268 266264007571 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266264007572 dimer interface [polypeptide binding]; other site 266264007573 conserved gate region; other site 266264007574 putative PBP binding loops; other site 266264007575 ABC-ATPase subunit interface; other site 266264007576 phosphate transporter permease subunit PstC; Provisional; Region: pstC; PRK11275 266264007577 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266264007578 dimer interface [polypeptide binding]; other site 266264007579 conserved gate region; other site 266264007580 putative PBP binding loops; other site 266264007581 ABC-ATPase subunit interface; other site 266264007582 PBP superfamily domain; Region: PBP_like_2; cl17296 266264007583 phosphoglucosamine mutase; Provisional; Region: glmM; PRK10887 266264007584 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 266264007585 active site 266264007586 substrate binding site [chemical binding]; other site 266264007587 metal binding site [ion binding]; metal-binding site 266264007588 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 266264007589 dihydropteroate synthase; Region: DHPS; TIGR01496 266264007590 substrate binding pocket [chemical binding]; other site 266264007591 dimer interface [polypeptide binding]; other site 266264007592 inhibitor binding site; inhibition site 266264007593 ATP-dependent Zn proteases [Posttranslational modification, protein turnover, chaperones]; Region: HflB; COG0465 266264007594 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 266264007595 Walker A motif; other site 266264007596 ATP binding site [chemical binding]; other site 266264007597 Walker B motif; other site 266264007598 arginine finger; other site 266264007599 Peptidase family M41; Region: Peptidase_M41; pfam01434 266264007600 FtsJ-like methyltransferase; Region: FtsJ; cl17430 266264007601 23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293 266264007602 Predicted RNA-binding protein containing KH domain, possibly ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG1534 266264007603 Domain of unknown function (DUF4149); Region: DUF4149; pfam13664 266264007604 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 266264007605 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 266264007606 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 266264007607 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 266264007608 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 266264007609 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 266264007610 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 266264007611 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 266264007612 ATP-grasp domain; Region: ATP-grasp_4; cl17255 266264007613 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 266264007614 IMP binding site; other site 266264007615 dimer interface [polypeptide binding]; other site 266264007616 interdomain contacts; other site 266264007617 partial ornithine binding site; other site 266264007618 leucine export protein LeuE; Provisional; Region: PRK10958 266264007619 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 266264007620 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 266264007621 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 266264007622 catalytic site [active] 266264007623 subunit interface [polypeptide binding]; other site 266264007624 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 266264007625 homotrimer interaction site [polypeptide binding]; other site 266264007626 putative active site [active] 266264007627 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 266264007628 active site 266264007629 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 266264007630 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 266264007631 acyl-activating enzyme (AAE) consensus motif; other site 266264007632 AMP binding site [chemical binding]; other site 266264007633 active site 266264007634 CoA binding site [chemical binding]; other site 266264007635 isovaleryl-CoA dehydrogenase; Region: PLN02519 266264007636 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 266264007637 active site 266264007638 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 266264007639 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 266264007640 substrate binding site [chemical binding]; other site 266264007641 oxyanion hole (OAH) forming residues; other site 266264007642 trimer interface [polypeptide binding]; other site 266264007643 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 266264007644 classical (c) SDRs; Region: SDR_c; cd05233 266264007645 NAD(P) binding site [chemical binding]; other site 266264007646 active site 266264007647 salicylyl-CoA 5-hydroxylase; Reviewed; Region: PRK08255 266264007648 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 266264007649 active site 266264007650 FMN binding site [chemical binding]; other site 266264007651 substrate binding site [chemical binding]; other site 266264007652 homotetramer interface [polypeptide binding]; other site 266264007653 catalytic residue [active] 266264007654 propionyl-CoA synthetase; Provisional; Region: prpE; PRK10524 266264007655 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 266264007656 acyl-activating enzyme (AAE) consensus motif; other site 266264007657 AMP binding site [chemical binding]; other site 266264007658 active site 266264007659 CoA binding site [chemical binding]; other site 266264007660 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 266264007661 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial protein Rv2277c and similar proteins; Region: GDPD_Rv2277c_like; cd08580 266264007662 putative active site [active] 266264007663 catalytic site [active] 266264007664 putative metal binding site [ion binding]; other site 266264007665 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 266264007666 N-acetyl-D-glucosamine binding site [chemical binding]; other site 266264007667 catalytic residue [active] 266264007668 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 266264007669 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 266264007670 hydroxyacylglutathione hydrolase; Region: GSH_gloB; TIGR03413 266264007671 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 266264007672 Methyltransferase domain; Region: Methyltransf_11; pfam08241 266264007673 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 266264007674 RNA/DNA hybrid binding site [nucleotide binding]; other site 266264007675 active site 266264007676 DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406 266264007677 DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131 266264007678 active site 266264007679 catalytic site [active] 266264007680 substrate binding site [chemical binding]; other site 266264007681 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 266264007682 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 266264007683 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 266264007684 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 266264007685 Soluble P-type ATPase [General function prediction only]; Region: COG4087 266264007686 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 266264007687 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 266264007688 Ligand Binding Site [chemical binding]; other site 266264007689 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 266264007690 Ligand Binding Site [chemical binding]; other site 266264007691 Subfamily of the nitroreductase family that includes BluB protein in Rhodobacter capsulatus is involved in the conversion of cobinamide to cobalamin in Cobalamin (vitamin B12) biosynthesis. Nitroreductases typically reduce their substrates by using NAD(P)...; Region: BluB; cd02145 266264007692 putative FMN binding site [chemical binding]; other site 266264007693 Putative ParB-like nuclease; Region: ParBc_2; cl17538 266264007694 Member of the Rhodanese Homology Domain superfamily, repeat 1. This CD includes putative rhodanese-related sulfurtransferases which contain 4 copies of the Rhodanese Homology Domain. This CD aligns the 1st repeat which does not contain the putative...; Region: 4RHOD_Repeat_1; cd01532 266264007695 active site residue [active] 266264007696 Member of the Rhodanese Homology Domain superfamily, repeat 2. This CD includes putative rhodanese-related sulfurtransferases which contain 4 copies of the Rhodanese Homology Domain. This CD aligns the 2nd repeat which does contain the putative catalytic...; Region: 4RHOD_Repeat_2; cd01533 266264007697 active site residue [active] 266264007698 Member of the Rhodanese Homology Domain superfamily, repeat 3. This CD includes putative rhodanese-related sulfurtransferases which contain 4 copies of the Rhodanese Homology Domain. This CD aligns the 3rd repeat which does not contain the putative...; Region: 4RHOD_Repeat_3; cd01534 266264007699 active site residue [active] 266264007700 Member of the Rhodanese Homology Domain superfamily, repeat 4. This CD includes putative rhodanese-related sulfurtransferases which contain 4 copies of the Rhodanese Homology Domain. This CD aligns the 4th repeat which, in general, contains the putative...; Region: 4RHOD_Repeat_4; cd01535 266264007701 active site residue [active] 266264007702 Predicted metal-dependent enzyme of the double-stranded beta helix superfamily [General function prediction only]; Region: COG5553 266264007703 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 266264007704 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 266264007705 active site 266264007706 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 266264007707 alkanesulfonate monooxygenase, FMNH(2)-dependent; Region: alk_sulf_monoox; TIGR03565 266264007708 dimer interface [polypeptide binding]; other site 266264007709 active site 266264007710 non-prolyl cis peptide bond; other site 266264007711 insertion regions; other site 266264007712 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 266264007713 NMT1-like family; Region: NMT1_2; pfam13379 266264007714 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 266264007715 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266264007716 dimer interface [polypeptide binding]; other site 266264007717 conserved gate region; other site 266264007718 putative PBP binding loops; other site 266264007719 ABC-ATPase subunit interface; other site 266264007720 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 266264007721 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 266264007722 Walker A/P-loop; other site 266264007723 ATP binding site [chemical binding]; other site 266264007724 Q-loop/lid; other site 266264007725 ABC transporter signature motif; other site 266264007726 Walker B; other site 266264007727 D-loop; other site 266264007728 H-loop/switch region; other site 266264007729 Cytochrome c; Region: Cytochrom_C; pfam00034 266264007730 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 266264007731 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 266264007732 putative active site [active] 266264007733 Isochorismatase family; Region: Isochorismatase; pfam00857 266264007734 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 266264007735 catalytic triad [active] 266264007736 conserved cis-peptide bond; other site 266264007737 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266264007738 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266264007739 LysR substrate binding domain; Region: LysR_substrate; pfam03466 266264007740 dimerization interface [polypeptide binding]; other site 266264007741 Cache domain; Region: Cache_1; pfam02743 266264007742 HAMP domain; Region: HAMP; pfam00672 266264007743 PAS domain S-box; Region: sensory_box; TIGR00229 266264007744 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 266264007745 putative active site [active] 266264007746 heme pocket [chemical binding]; other site 266264007747 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 266264007748 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 266264007749 metal binding site [ion binding]; metal-binding site 266264007750 active site 266264007751 I-site; other site 266264007752 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 266264007753 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 266264007754 Predicted small integral membrane protein (DUF2160); Region: DUF2160; pfam09928 266264007755 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 266264007756 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266264007757 dimer interface [polypeptide binding]; other site 266264007758 conserved gate region; other site 266264007759 putative PBP binding loops; other site 266264007760 ABC-ATPase subunit interface; other site 266264007761 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 266264007762 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266264007763 dimer interface [polypeptide binding]; other site 266264007764 conserved gate region; other site 266264007765 putative PBP binding loops; other site 266264007766 ABC-ATPase subunit interface; other site 266264007767 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 266264007768 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 266264007769 Walker A/P-loop; other site 266264007770 ATP binding site [chemical binding]; other site 266264007771 Q-loop/lid; other site 266264007772 ABC transporter signature motif; other site 266264007773 Walker B; other site 266264007774 D-loop; other site 266264007775 H-loop/switch region; other site 266264007776 TOBE domain; Region: TOBE_2; pfam08402 266264007777 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 266264007778 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 266264007779 Walker A/P-loop; other site 266264007780 ATP binding site [chemical binding]; other site 266264007781 Q-loop/lid; other site 266264007782 ABC transporter signature motif; other site 266264007783 Walker B; other site 266264007784 D-loop; other site 266264007785 H-loop/switch region; other site 266264007786 TOBE domain; Region: TOBE; pfam03459 266264007787 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 266264007788 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 266264007789 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 266264007790 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 266264007791 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 266264007792 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 266264007793 putative active site [active] 266264007794 putative substrate binding site [chemical binding]; other site 266264007795 putative cosubstrate binding site; other site 266264007796 catalytic site [active] 266264007797 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belong to this superfamily requires a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_hydrolase_3; cd03676 266264007798 nudix motif; other site 266264007799 glycerol kinase; Provisional; Region: glpK; PRK00047 266264007800 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 266264007801 N- and C-terminal domain interface [polypeptide binding]; other site 266264007802 active site 266264007803 MgATP binding site [chemical binding]; other site 266264007804 catalytic site [active] 266264007805 metal binding site [ion binding]; metal-binding site 266264007806 glycerol binding site [chemical binding]; other site 266264007807 homotetramer interface [polypeptide binding]; other site 266264007808 homodimer interface [polypeptide binding]; other site 266264007809 FBP binding site [chemical binding]; other site 266264007810 protein IIAGlc interface [polypeptide binding]; other site 266264007811 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 266264007812 Domain of unknown function (DUF4154); Region: DUF4154; pfam13689 266264007813 putative inner membrane diguanylate cyclase; Provisional; Region: PRK09966 266264007814 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 266264007815 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 266264007816 metal binding site [ion binding]; metal-binding site 266264007817 active site 266264007818 I-site; other site 266264007819 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 266264007820 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 266264007821 ligand binding site [chemical binding]; other site 266264007822 PAS domain; Region: PAS; smart00091 266264007823 cyclic-di-GMP phosphodiesterase; Provisional; Region: PRK11359 266264007824 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 266264007825 putative active site [active] 266264007826 heme pocket [chemical binding]; other site 266264007827 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 266264007828 metal binding site [ion binding]; metal-binding site 266264007829 active site 266264007830 I-site; other site 266264007831 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 266264007832 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 266264007833 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 266264007834 homodimer interface [polypeptide binding]; other site 266264007835 substrate-cofactor binding pocket; other site 266264007836 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266264007837 catalytic residue [active] 266264007838 cellulose synthase regulator protein; Provisional; Region: PRK11114 266264007839 endo-1,4-D-glucanase; Provisional; Region: PRK11097 266264007840 cellulose synthase subunit BcsC; Provisional; Region: PRK11447 266264007841 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 266264007842 binding surface 266264007843 TPR motif; other site 266264007844 Cellulose synthase operon protein C C-terminus (BCSC_C); Region: BCSC_C; pfam05420 266264007845 cellulose biosynthesis protein BcsE; Region: cellulose_bcsE; TIGR03369 266264007846 cellulose synthase operon protein YhjQ; Region: cellulose_yhjQ; TIGR03371 266264007847 cellulose synthase catalytic subunit (UDP-forming); Region: CelA; TIGR03030 266264007848 Cellulose synthase-like protein; Region: PLN02893 266264007849 CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421 266264007850 DXD motif; other site 266264007851 PilZ domain; Region: PilZ; pfam07238 266264007852 cellulose synthase operon protein YhjU; Region: cellulose_yhjU; TIGR03368 266264007853 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 266264007854 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 266264007855 Domain of unknown function (DUF1987); Region: DUF1987; pfam09345 266264007856 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 266264007857 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 266264007858 metal binding site [ion binding]; metal-binding site 266264007859 active site 266264007860 I-site; other site 266264007861 Herpesvirus UL33-like protein; Region: Herpes_UL33; cl17329 266264007862 flagellar capping protein; Reviewed; Region: fliD; PRK08032 266264007863 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 266264007864 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 266264007865 Transposase, Mutator family; Region: Transposase_mut; pfam00872 266264007866 MULE transposase domain; Region: MULE; pfam10551 266264007867 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 266264007868 probable sodium:solute symporter, VC_2705 subfamily; Region: Na_symport_lg; TIGR03648 266264007869 acetyl-CoA synthetase; Provisional; Region: PRK00174 266264007870 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 266264007871 active site 266264007872 CoA binding site [chemical binding]; other site 266264007873 acyl-activating enzyme (AAE) consensus motif; other site 266264007874 AMP binding site [chemical binding]; other site 266264007875 acetate binding site [chemical binding]; other site 266264007876 EamA-like transporter family; Region: EamA; pfam00892 266264007877 hypothetical protein; Provisional; Region: PRK05208 266264007878 Fumarate hydratase (Fumerase); Region: Fumerase; pfam05681 266264007879 Fumarase C-terminus; Region: Fumerase_C; pfam05683 266264007880 glutamate racemase; Provisional; Region: PRK00865 266264007881 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 266264007882 ATPases of the AAA+ class [Posttranslational modification, protein turnover, chaperones]; Region: SpoVK; COG0464 266264007883 Walker A motif; other site 266264007884 ATP binding site [chemical binding]; other site 266264007885 Walker B motif; other site 266264007886 arginine finger; other site 266264007887 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 266264007888 Walker A motif; other site 266264007889 ATP binding site [chemical binding]; other site 266264007890 Walker B motif; other site 266264007891 arginine finger; other site 266264007892 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 266264007893 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 266264007894 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 266264007895 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 266264007896 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 266264007897 Hemin uptake protein hemP; Region: hemP; pfam10636 266264007898 Uncharacterized protein, possibly involved in utilization of glycolate and propanediol [General function prediction only]; Region: GlcG; COG3193 266264007899 Predicted membrane protein [Function unknown]; Region: COG2855 266264007900 putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837 266264007901 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266264007902 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 266264007903 putative dimerization interface [polypeptide binding]; other site 266264007904 Kef-type K+ transport system, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: RosB; COG4651 266264007905 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 266264007906 Domain of unknown function (DUF305); Region: DUF305; cl17794 266264007907 Predicted transcriptional regulator [Transcription]; Region: AlpA; COG3311 266264007908 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 266264007909 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 266264007910 Magnesium ion binding site [ion binding]; other site 266264007911 integrating conjugative element, PFGI_1 class, ParB family protein; Region: ICE_PFGI_1_parB; TIGR03764 266264007912 ParB-like nuclease domain; Region: ParBc; pfam02195 266264007913 Protein of unknown function (DUF2857); Region: DUF2857; pfam11198 266264007914 Domain of unknown function (DUF1845); Region: DUF1845; pfam08900 266264007915 Protein of unknown function (DUF3158); Region: DUF3158; pfam11358 266264007916 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 266264007917 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 266264007918 dimer interface [polypeptide binding]; other site 266264007919 ssDNA binding site [nucleotide binding]; other site 266264007920 tetramer (dimer of dimers) interface [polypeptide binding]; other site 266264007921 DNA topoisomerase III; Provisional; Region: PRK07726 266264007922 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 266264007923 active site 266264007924 putative interdomain interaction site [polypeptide binding]; other site 266264007925 putative metal-binding site [ion binding]; other site 266264007926 putative nucleotide binding site [chemical binding]; other site 266264007927 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 266264007928 domain I; other site 266264007929 DNA binding groove [nucleotide binding] 266264007930 phosphate binding site [ion binding]; other site 266264007931 domain II; other site 266264007932 domain III; other site 266264007933 nucleotide binding site [chemical binding]; other site 266264007934 catalytic site [active] 266264007935 domain IV; other site 266264007936 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 266264007937 Cation efflux family; Region: Cation_efflux; cl00316 266264007938 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 266264007939 Cd(II)/Pb(II)-responsive transcriptional regulator; Region: CadR-PbrR; TIGR02047 266264007940 Helix-Turn-Helix DNA binding domain of the CadR and PbrR transcription regulators; Region: HTH_CadR-PbrR; cd04784 266264007941 DNA binding residues [nucleotide binding] 266264007942 dimer interface [polypeptide binding]; other site 266264007943 putative metal binding site [ion binding]; other site 266264007944 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 266264007945 metal-binding site [ion binding] 266264007946 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 266264007947 metal-binding site [ion binding] 266264007948 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cl00207 266264007949 metal-binding site [ion binding] 266264007950 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 266264007951 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 266264007952 metal-binding site [ion binding] 266264007953 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 266264007954 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 266264007955 putative transcriptional regulator MerR; Provisional; Region: PRK13752 266264007956 Helix-Turn-Helix DNA binding domain of the MerR1 transcription regulator; Region: HTH_MerR1; cd04783 266264007957 DNA binding residues [nucleotide binding] 266264007958 dimer interface [polypeptide binding]; other site 266264007959 mercury binding site [ion binding]; other site 266264007960 putative mercuric transport protein; Provisional; Region: PRK13751 266264007961 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 266264007962 metal-binding site [ion binding] 266264007963 mercuric reductase 266264007964 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 266264007965 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 266264007966 transposase (fragment) 266264007967 transposase (fragment) 266264007968 Protein of unknown function (DUF3085); Region: DUF3085; pfam11284 266264007969 Protein of unknown function (DUF3577); Region: DUF3577; pfam12101 266264007970 Protein of unknown function (DUF3577); Region: DUF3577; pfam12101 266264007971 Domain of unknown function (DUF932); Region: DUF932; pfam06067 266264007972 Protein of unknown function (DUF3275); Region: DUF3275; pfam11679 266264007973 Methyltransferase domain; Region: Methyltransf_26; pfam13659 266264007974 S-adenosylmethionine binding site [chemical binding]; other site 266264007975 DEAD-like helicases superfamily; Region: DEXDc; smart00487 266264007976 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 266264007977 nucleotide binding region [chemical binding]; other site 266264007978 ATP-binding site [chemical binding]; other site 266264007979 conjugative transfer region protein, TIGR03748 family; Region: conj_PilL 266264007980 integrating conjugative element protein, PFL_4693 family; Region: conj_TIGR03759 266264007981 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 266264007982 N-acetyl-D-glucosamine binding site [chemical binding]; other site 266264007983 catalytic residue [active] 266264007984 Protein of unknown function (DUF2859); Region: DUF2859; pfam11072 266264007985 conjugative coupling factor TraD, SXT/TOL subfamily; Region: SXT_TraD; TIGR03743 266264007986 conjugative coupling factor TraD, TOL family; Region: conj_TOL_TraD; TIGR03754 266264007987 integrating conjugative element membrane protein, PFL_4697 family; Region: conj_TIGR03747 266264007988 AAA domain; Region: AAA_23; pfam13476 266264007989 P-loop containing region of AAA domain; Region: AAA_29; cl17516 266264007990 AAA domain; Region: AAA_21; pfam13304 266264007991 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 266264007992 ABC transporter signature motif; other site 266264007993 Walker B; other site 266264007994 D-loop; other site 266264007995 H-loop/switch region; other site 266264007996 Nucleotidyltransferase (NT) domain of 2'5'-oligoadenylate (2-5A)synthetase (2-5OAS) and class I CCA-adding enzyme; Region: NT_2-5OAS_ClassI-CCAase; cd05400 266264007997 active site 266264007998 NTP binding site [chemical binding]; other site 266264007999 metal binding triad [ion binding]; metal-binding site 266264008000 HORMA domain; Region: HORMA; pfam02301 266264008001 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 266264008002 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 266264008003 Walker A motif; other site 266264008004 ATP binding site [chemical binding]; other site 266264008005 Walker B motif; other site 266264008006 arginine finger; other site 266264008007 PIN domain; Region: PIN_3; pfam13470 266264008008 DNA binding domain, excisionase family; Region: excise; TIGR01764 266264008009 integrative conjugative element protein, RAQPRD family; Region: ICE_RAQPRD; TIGR01690 266264008010 Plasmid protein of unknown function (Plasmid_RAQPRD); Region: Plasmid_RAQPRD; pfam09686 266264008011 Protein of unknown function (DUF3262); Region: DUF3262; pfam11660 266264008012 integrating conjugative element membrane protein, PFL_4702 family; Region: conj_TIGR03745 266264008013 Protein of unknown function (DUF3487); Region: DUF3487; pfam11990 266264008014 integrating conjugative element protein, PFL_4703 family; Region: conj_TIGR03746 266264008015 Protein of unknown function (DUF3438); Region: DUF3438; pfam11920 266264008016 integrating conjugative element protein, PFL_4705 family; Region: conj_TIGR03752 266264008017 conjugative transfer region lipoprotein, TIGR03751 family; Region: conj_TIGR03751 266264008018 conjugative transfer ATPase, PFL_4706 family; Region: traC_PFL_4706; TIGR03744 266264008019 F pilus assembly Type-IV secretion system for plasmid transfer; Region: TraC_F_IV; pfam11130 266264008020 Thioredoxin; Region: Thioredoxin_4; cl17273 266264008021 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 266264008022 MPN+ (JAMM) motif; other site 266264008023 Zinc-binding site [ion binding]; other site 266264008024 Protein of unknown function (DUF1525); Region: DUF1525; pfam07511 266264008025 integrating conjugative element protein, PFL_4710 family; Region: conj_TIGR03756 266264008026 integrating conjugative element protein, PFL_4711 family; Region: conj_TIGR03755 266264008027 TraG-like protein, N-terminal region; Region: TraG_N; pfam07916 266264008028 Protein of unknown function (DUF3742); Region: DUF3742; pfam12553 266264008029 RES domain; Region: RES; smart00953 266264008030 integrating conjugative element relaxase, PFL_4751 family; Region: ICE_TraI_Pfluor; TIGR03760 266264008031 Putative helicase; Region: TraI_2; pfam07514 266264008032 Protein of unknown function (DUF1528); Region: DUF1528; pfam07515 266264008033 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 266264008034 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 266264008035 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 266264008036 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 266264008037 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 266264008038 substrate binding site [chemical binding]; other site 266264008039 oxyanion hole (OAH) forming residues; other site 266264008040 trimer interface [polypeptide binding]; other site 266264008041 DsrE/DsrF-like family; Region: DrsE; pfam02635 266264008042 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 266264008043 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 266264008044 dimerization interface [polypeptide binding]; other site 266264008045 putative DNA binding site [nucleotide binding]; other site 266264008046 putative Zn2+ binding site [ion binding]; other site 266264008047 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YgaP, and similar uncharacterized putative rhodanese-related sulfurtransferases; Region: RHOD_YgaP; cd01527 266264008048 active site residue [active] 266264008049 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 266264008050 Putative phosphatase (DUF442); Region: DUF442; cl17385 266264008051 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 266264008052 Heme-copper oxidase subunit I. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane. The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275 266264008053 Low-spin heme binding site [chemical binding]; other site 266264008054 Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115 266264008055 D-pathway; other site 266264008056 Putative water exit pathway; other site 266264008057 Binuclear center (active site) [active] 266264008058 K-pathway; other site 266264008059 Putative proton exit pathway; other site 266264008060 Cytochrome C oxidase, mono-heme subunit/FixO; Region: FixO; cl01130 266264008061 Cytochrome c; Region: Cytochrom_C; cl11414 266264008062 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 266264008063 Cytochrome c; Region: Cytochrom_C; cl11414 266264008064 Cytochrome c [Energy production and conversion]; Region: COG3258 266264008065 Cytochrome c; Region: Cytochrom_C; pfam00034 266264008066 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 266264008067 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 266264008068 metal-binding site [ion binding] 266264008069 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 266264008070 Soluble P-type ATPase [General function prediction only]; Region: COG4087 266264008071 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 266264008072 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 266264008073 putative active site [active] 266264008074 catalytic triad [active] 266264008075 putative dimer interface [polypeptide binding]; other site 266264008076 Putative sensor-kinase ArmS (part 2) 266264008077 Helix-turn-helix domain; Region: HTH_38; pfam13936 266264008078 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 266264008079 Integrase core domain; Region: rve; pfam00665 266264008080 Putative sensor-kinase ArmS (part1) 266264008081 DNA-binding transcriptional regulator BasR; Provisional; Region: PRK10643 266264008082 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266264008083 active site 266264008084 phosphorylation site [posttranslational modification] 266264008085 intermolecular recognition site; other site 266264008086 dimerization interface [polypeptide binding]; other site 266264008087 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 266264008088 DNA binding site [nucleotide binding] 266264008089 cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13538 266264008090 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 266264008091 Walker A/P-loop; other site 266264008092 ATP binding site [chemical binding]; other site 266264008093 Q-loop/lid; other site 266264008094 ABC transporter signature motif; other site 266264008095 Walker B; other site 266264008096 D-loop; other site 266264008097 H-loop/switch region; other site 266264008098 CcmB protein; Region: CcmB; pfam03379 266264008099 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 266264008100 Heme exporter protein D (CcmD); Region: CcmD; cl11475 266264008101 CcmE; Region: CcmE; pfam03100 266264008102 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: CcmF; COG1138 266264008103 periplasmic protein thiol:disulfide oxidoreductases, DsbE subfamily; Region: dsbE; TIGR00385 266264008104 TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010 266264008105 catalytic residues [active] 266264008106 central insert; other site 266264008107 Cytochrome C biogenesis protein; Region: CcmH; pfam03918 266264008108 cytochrome c-type biogenesis protein CcmI; Region: cytochro_ccmI; TIGR03142 266264008109 Tfp pilus assembly protein PilF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilF; COG3063 266264008110 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 266264008111 binding surface 266264008112 TPR motif; other site 266264008113 thiol:disulfide interchange protein precursor; Provisional; Region: dipZ; PRK00293 266264008114 Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412 266264008115 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 266264008116 DsbD alpha interface [polypeptide binding]; other site 266264008117 catalytic residues [active] 266264008118 Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478 266264008119 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 266264008120 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 266264008121 catalytic residues [active] 266264008122 disulfide isomerase/thiol-disulfide oxidase; Provisional; Region: dsbG; PRK11657 266264008123 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 266264008124 dimerization domain [polypeptide binding]; other site 266264008125 dimer interface [polypeptide binding]; other site 266264008126 catalytic residues [active] 266264008127 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 266264008128 dihydrolipoamide dehydrogenase; Validated; Region: PRK06292 266264008129 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 266264008130 DsrE/DsrF-like family; Region: DrsE; cl00672 266264008131 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266264008132 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 266264008133 dimerization interface [polypeptide binding]; other site 266264008134 substrate binding pocket [chemical binding]; other site 266264008135 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 266264008136 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 266264008137 sequence-specific DNA binding site [nucleotide binding]; other site 266264008138 salt bridge; other site 266264008139 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 266264008140 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266264008141 dimerization interface [polypeptide binding]; other site 266264008142 tyrosine-based site specific recombinase (part 2) 266264008143 Integrase core domain; Region: rve; pfam00665 266264008144 AAA domain; Region: AAA_22; pfam13401 266264008145 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 266264008146 Walker A motif; other site 266264008147 ATP binding site [chemical binding]; other site 266264008148 Walker B motif; other site 266264008149 arginine finger; other site 266264008150 tyrosine-based site specific recombinase (part1) 266264008151 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 266264008152 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 266264008153 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 266264008154 GIY-YIG motif/motif A; other site 266264008155 active site 266264008156 catalytic site [active] 266264008157 putative DNA binding site [nucleotide binding]; other site 266264008158 metal binding site [ion binding]; metal-binding site 266264008159 UvrB/uvrC motif; Region: UVR; pfam02151 266264008160 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 266264008161 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4394 266264008162 Uncharacterized protein conserved in bacteria (DUF2331); Region: DUF2331; pfam10093 266264008163 elongation factor P; Validated; Region: PRK00529 266264008164 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 266264008165 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 266264008166 RNA binding site [nucleotide binding]; other site 266264008167 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 266264008168 RNA binding site [nucleotide binding]; other site 266264008169 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 266264008170 beta-hexosaminidase; Provisional; Region: PRK05337 266264008171 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 266264008172 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003 266264008173 active site 266264008174 hydrophilic channel; other site 266264008175 dimerization interface [polypeptide binding]; other site 266264008176 catalytic residues [active] 266264008177 active site lid [active] 266264008178 Recombination protein O N terminal; Region: RecO_N; pfam11967 266264008179 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 266264008180 Recombination protein O C terminal; Region: RecO_C; pfam02565 266264008181 GTPase Era; Reviewed; Region: era; PRK00089 266264008182 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 266264008183 G1 box; other site 266264008184 GTP/Mg2+ binding site [chemical binding]; other site 266264008185 Switch I region; other site 266264008186 G2 box; other site 266264008187 Switch II region; other site 266264008188 G3 box; other site 266264008189 G4 box; other site 266264008190 G5 box; other site 266264008191 KH domain; Region: KH_2; pfam07650 266264008192 ribonuclease III, bacterial; Region: RNaseIII; TIGR02191 266264008193 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 266264008194 dimerization interface [polypeptide binding]; other site 266264008195 active site 266264008196 metal binding site [ion binding]; metal-binding site 266264008197 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 266264008198 signal peptidase I; Provisional; Region: PRK10861 266264008199 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 266264008200 Catalytic site [active] 266264008201 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 266264008202 GTP-binding protein LepA; Provisional; Region: PRK05433 266264008203 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 266264008204 G1 box; other site 266264008205 putative GEF interaction site [polypeptide binding]; other site 266264008206 GTP/Mg2+ binding site [chemical binding]; other site 266264008207 Switch I region; other site 266264008208 G2 box; other site 266264008209 G3 box; other site 266264008210 Switch II region; other site 266264008211 G4 box; other site 266264008212 G5 box; other site 266264008213 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 266264008214 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 266264008215 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 266264008216 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 266264008217 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 266264008218 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 266264008219 protein binding site [polypeptide binding]; other site 266264008220 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 266264008221 protein binding site [polypeptide binding]; other site 266264008222 anti-sigma E factor; Provisional; Region: rseB; PRK09455 266264008223 Negative regulator of sigma E activity [Signal transduction mechanisms]; Region: RseB; COG3026 266264008224 Anti sigma-E protein RseA, N-terminal domain; Region: RseA_N; pfam03872 266264008225 RNA polymerase sigma factor RpoE; Region: RpoE_Sigma70; TIGR02939 266264008226 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 266264008227 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 266264008228 DNA binding residues [nucleotide binding] 266264008229 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314 266264008230 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 266264008231 dimer interface [polypeptide binding]; other site 266264008232 active site 266264008233 acyl carrier protein; Provisional; Region: acpP; PRK00982 266264008234 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 266264008235 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 266264008236 NAD(P) binding site [chemical binding]; other site 266264008237 homotetramer interface [polypeptide binding]; other site 266264008238 homodimer interface [polypeptide binding]; other site 266264008239 active site 266264008240 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 266264008241 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 266264008242 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 266264008243 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 266264008244 dimer interface [polypeptide binding]; other site 266264008245 active site 266264008246 CoA binding pocket [chemical binding]; other site 266264008247 putative phosphate acyltransferase; Provisional; Region: PRK05331 266264008248 50S ribosomal protein L32; Validated; Region: rpmF; PRK01110 266264008249 Uncharacterized ACR, COG1399; Region: DUF177; pfam02620 266264008250 Maf-like protein; Region: Maf; pfam02545 266264008251 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 266264008252 active site 266264008253 dimer interface [polypeptide binding]; other site 266264008254 Uncharacterized subfamily of the tetrapyrrole methylase family similar to ribosomal RNA small subunit methyltransferase I (RsmI); Region: RsmI_like; cd11649 266264008255 putative SAM binding site [chemical binding]; other site 266264008256 homodimer interface [polypeptide binding]; other site 266264008257 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 266264008258 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 266264008259 tandem repeat interface [polypeptide binding]; other site 266264008260 oligomer interface [polypeptide binding]; other site 266264008261 active site residues [active] 266264008262 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 266264008263 iron-sulfur cluster [ion binding]; other site 266264008264 [2Fe-2S] cluster binding site [ion binding]; other site 266264008265 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 266264008266 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 266264008267 motif II; other site 266264008268 23S rRNA pseudouridylate synthase C; Provisional; Region: PRK11025 266264008269 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 266264008270 RNA binding surface [nucleotide binding]; other site 266264008271 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 266264008272 active site 266264008273 Ribonucleases G and E [Translation, ribosomal structure and biogenesis]; Region: CafA; COG1530 266264008274 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 266264008275 homodimer interface [polypeptide binding]; other site 266264008276 oligonucleotide binding site [chemical binding]; other site 266264008277 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 266264008278 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 266264008279 FeS/SAM binding site; other site 266264008280 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 266264008281 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 266264008282 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 266264008283 GTP binding site; other site 266264008284 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 266264008285 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 266264008286 dimer interface [polypeptide binding]; other site 266264008287 putative functional site; other site 266264008288 putative MPT binding site; other site 266264008289 Predicted nuclease of restriction endonuclease-like fold, RmuC family [General function prediction only]; Region: COG1322 266264008290 RmuC family; Region: RmuC; pfam02646 266264008291 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 266264008292 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 266264008293 dimerization interface [polypeptide binding]; other site 266264008294 ligand binding site [chemical binding]; other site 266264008295 NADP binding site [chemical binding]; other site 266264008296 catalytic site [active] 266264008297 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 266264008298 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 266264008299 Uncharacterized conserved protein [Function unknown]; Region: COG1556 266264008300 nicotinate phosphoribosyltransferase; Region: NAPRTase; TIGR01514 266264008301 Nicotinate phosphoribosyltransferase (NAPRTase), related to PncB. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting; Region: PncB_like; cd01401 266264008302 active site 266264008303 Ferredoxin [Energy production and conversion]; Region: COG1146 266264008304 4Fe-4S binding domain; Region: Fer4; cl02805 266264008305 Domain of unknown function (DUF3470); Region: DUF3470; pfam11953 266264008306 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 266264008307 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 266264008308 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 266264008309 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 266264008310 Helix-turn-helix domain; Region: HTH_18; pfam12833 266264008311 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 266264008312 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 266264008313 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 266264008314 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 266264008315 nodulation ABC transporter NodI; Provisional; Region: PRK13537 266264008316 ATP-binding cassette domain of the lipid transporters, subfamily A; Region: ABC_subfamily_A; cd03263 266264008317 Walker A/P-loop; other site 266264008318 ATP binding site [chemical binding]; other site 266264008319 Q-loop/lid; other site 266264008320 ABC transporter signature motif; other site 266264008321 Walker B; other site 266264008322 D-loop; other site 266264008323 H-loop/switch region; other site 266264008324 ABC-2 type transporter; Region: ABC2_membrane; cl17235 266264008325 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 266264008326 O-succinylhomoserine sulfhydrylase; Validated; Region: PRK08133 266264008327 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 266264008328 homodimer interface [polypeptide binding]; other site 266264008329 substrate-cofactor binding pocket; other site 266264008330 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266264008331 catalytic residue [active] 266264008332 amidophosphoribosyltransferase; Provisional; Region: PRK09246 266264008333 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 266264008334 active site 266264008335 tetramer interface [polypeptide binding]; other site 266264008336 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 266264008337 active site 266264008338 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 266264008339 Colicin V production protein; Region: Colicin_V; pfam02674 266264008340 Sporulation related domain; Region: SPOR; pfam05036 266264008341 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 266264008342 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 266264008343 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 266264008344 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 266264008345 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 266264008346 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 266264008347 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 266264008348 substrate binding site [chemical binding]; other site 266264008349 active site 266264008350 catalytic residues [active] 266264008351 heterodimer interface [polypeptide binding]; other site 266264008352 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 266264008353 DNA methylase; Region: N6_N4_Mtase; pfam01555 266264008354 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 266264008355 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 266264008356 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266264008357 catalytic residue [active] 266264008358 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 266264008359 active site 266264008360 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 266264008361 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 266264008362 dimerization interface 3.5A [polypeptide binding]; other site 266264008363 active site 266264008364 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 266264008365 FimV C-terminal domain; Region: FimV_Cterm; TIGR03504 266264008366 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK06598 266264008367 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 266264008368 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 266264008369 tartrate dehydrogenase; Region: TTC; TIGR02089 266264008370 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 266264008371 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 266264008372 substrate binding site [chemical binding]; other site 266264008373 Entericidin EcnA/B family; Region: Entericidin; cl02322 266264008374 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 266264008375 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 266264008376 substrate binding site [chemical binding]; other site 266264008377 ligand binding site [chemical binding]; other site 266264008378 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 266264008379 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 266264008380 Walker A/P-loop; other site 266264008381 ATP binding site [chemical binding]; other site 266264008382 Q-loop/lid; other site 266264008383 ABC transporter signature motif; other site 266264008384 Walker B; other site 266264008385 D-loop; other site 266264008386 H-loop/switch region; other site 266264008387 leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livG; PRK11300 266264008388 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 266264008389 Walker A/P-loop; other site 266264008390 ATP binding site [chemical binding]; other site 266264008391 Q-loop/lid; other site 266264008392 ABC transporter signature motif; other site 266264008393 Walker B; other site 266264008394 D-loop; other site 266264008395 H-loop/switch region; other site 266264008396 leucine/isoleucine/valine transporter permease subunit; Provisional; Region: livM; PRK11301 266264008397 Domain of unknown function (DUF3382); Region: DUF3382; pfam11862 266264008398 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 266264008399 TM-ABC transporter signature motif; other site 266264008400 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 266264008401 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 266264008402 TM-ABC transporter signature motif; other site 266264008403 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 266264008404 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 266264008405 dimerization interface [polypeptide binding]; other site 266264008406 ligand binding site [chemical binding]; other site 266264008407 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 266264008408 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 266264008409 dimer interface [polypeptide binding]; other site 266264008410 active site 266264008411 citrylCoA binding site [chemical binding]; other site 266264008412 NADH binding [chemical binding]; other site 266264008413 cationic pore residues; other site 266264008414 oxalacetate/citrate binding site [chemical binding]; other site 266264008415 coenzyme A binding site [chemical binding]; other site 266264008416 catalytic triad [active] 266264008417 Flavinator of succinate dehydrogenase; Region: Sdh5; cl01110 266264008418 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 266264008419 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 266264008420 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07057 266264008421 L-aspartate oxidase; Provisional; Region: PRK06175 266264008422 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 266264008423 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. E. coli SQR, a member of this subfamily, reduces the...; Region: SQR_TypeC_SdhD; cd03494 266264008424 SdhC subunit interface [polypeptide binding]; other site 266264008425 proximal heme binding site [chemical binding]; other site 266264008426 cardiolipin binding site; other site 266264008427 Iron-sulfur protein interface; other site 266264008428 proximal quinone binding site [chemical binding]; other site 266264008429 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499 266264008430 Iron-sulfur protein interface; other site 266264008431 proximal quinone binding site [chemical binding]; other site 266264008432 SdhD (CybS) interface [polypeptide binding]; other site 266264008433 proximal heme binding site [chemical binding]; other site 266264008434 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 266264008435 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266264008436 DNA-binding site [nucleotide binding]; DNA binding site 266264008437 UTRA domain; Region: UTRA; pfam07702 266264008438 malate dehydrogenase; Provisional; Region: PRK05442 266264008439 Chloroplast-like malate dehydrogenases; Region: MDH_choloroplast_like; cd01338 266264008440 NAD(P) binding site [chemical binding]; other site 266264008441 dimer interface [polypeptide binding]; other site 266264008442 malate binding site [chemical binding]; other site 266264008443 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 266264008444 aconitate hydratase; Provisional; Region: acnA; PRK12881 266264008445 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 266264008446 substrate binding site [chemical binding]; other site 266264008447 ligand binding site [chemical binding]; other site 266264008448 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 266264008449 substrate binding site [chemical binding]; other site 266264008450 Protein of unknown function (DUF2863); Region: DUF2863; pfam11062 266264008451 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 266264008452 S-adenosylmethionine binding site [chemical binding]; other site 266264008453 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_2; cd08498 266264008454 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 266264008455 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 266264008456 Uncharacterized protein conserved in bacteria containing a divergent form of TPR repeats [Function unknown]; Region: COG4700 266264008457 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 266264008458 dimerization interface [polypeptide binding]; other site 266264008459 putative DNA binding site [nucleotide binding]; other site 266264008460 putative Zn2+ binding site [ion binding]; other site 266264008461 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 266264008462 putative hydrophobic ligand binding site [chemical binding]; other site 266264008463 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 266264008464 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 266264008465 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299 266264008466 N-terminal domain interface [polypeptide binding]; other site 266264008467 dimer interface [polypeptide binding]; other site 266264008468 substrate binding pocket (H-site) [chemical binding]; other site 266264008469 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 266264008470 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 266264008471 Cytochrome c; Region: Cytochrom_C; pfam00034 266264008472 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 266264008473 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 266264008474 Gluconate 2-dehydrogenase subunit 3; Region: Gluconate_2-dh3; pfam13618 266264008475 MUG-like Uracil-DNA glycosylase enzyme family; Region: UDG_MUG_like; cd10032 266264008476 putative active site [active] 266264008477 heat shock protein 90; Provisional; Region: PRK05218 266264008478 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266264008479 ATP binding site [chemical binding]; other site 266264008480 Mg2+ binding site [ion binding]; other site 266264008481 G-X-G motif; other site 266264008482 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 266264008483 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266264008484 DNA-binding site [nucleotide binding]; DNA binding site 266264008485 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 266264008486 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266264008487 homodimer interface [polypeptide binding]; other site 266264008488 catalytic residue [active] 266264008489 Glyoxalase-like domain; Region: Glyoxalase_3; pfam13468 266264008490 Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain [General function prediction only]; Region: COG2872 266264008491 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 266264008492 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 266264008493 EamA-like transporter family; Region: EamA; pfam00892 266264008494 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 266264008495 homotrimer interaction site [polypeptide binding]; other site 266264008496 putative active site [active] 266264008497 aspartate aminotransferase; Provisional; Region: PRK05764 266264008498 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 266264008499 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266264008500 homodimer interface [polypeptide binding]; other site 266264008501 catalytic residue [active] 266264008502 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 266264008503 GST_N family, unknown subfamily 2; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_2; cd03047 266264008504 putative C-terminal domain interface [polypeptide binding]; other site 266264008505 putative GSH binding site (G-site) [chemical binding]; other site 266264008506 putative dimer interface [polypeptide binding]; other site 266264008507 C-terminal, alpha helical domain of an unknown subfamily 2 of Glutathione S-transferases; Region: GST_C_2; cd03180 266264008508 putative N-terminal domain interface [polypeptide binding]; other site 266264008509 putative dimer interface [polypeptide binding]; other site 266264008510 putative substrate binding pocket (H-site) [chemical binding]; other site 266264008511 L-lactate permease; Region: Lactate_perm; cl00701 266264008512 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 266264008513 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 266264008514 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 266264008515 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 266264008516 Walker A/P-loop; other site 266264008517 ATP binding site [chemical binding]; other site 266264008518 Q-loop/lid; other site 266264008519 ABC transporter signature motif; other site 266264008520 Walker B; other site 266264008521 D-loop; other site 266264008522 H-loop/switch region; other site 266264008523 Chromate transporter; Region: Chromate_transp; pfam02417 266264008524 Chromate transporter; Region: Chromate_transp; pfam02417 266264008525 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 266264008526 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 266264008527 CAP-like domain; other site 266264008528 active site 266264008529 primary dimer interface [polypeptide binding]; other site 266264008530 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 266264008531 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 266264008532 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 266264008533 N-acetyl-D-glucosamine binding site [chemical binding]; other site 266264008534 catalytic residue [active] 266264008535 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 266264008536 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266264008537 ATP binding site [chemical binding]; other site 266264008538 Mg2+ binding site [ion binding]; other site 266264008539 G-X-G motif; other site 266264008540 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 266264008541 anchoring element; other site 266264008542 dimer interface [polypeptide binding]; other site 266264008543 ATP binding site [chemical binding]; other site 266264008544 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 266264008545 active site 266264008546 metal binding site [ion binding]; metal-binding site 266264008547 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 266264008548 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266264008549 Major Facilitator Superfamily; Region: MFS_1; pfam07690 266264008550 putative substrate translocation pore; other site 266264008551 ABC transporter ATPase component; Reviewed; Region: PRK11147 266264008552 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 266264008553 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 266264008554 ABC transporter; Region: ABC_tran_2; pfam12848 266264008555 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 266264008556 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 266264008557 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 266264008558 DNA binding residues [nucleotide binding] 266264008559 dimerization interface [polypeptide binding]; other site 266264008560 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 266264008561 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 266264008562 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 266264008563 acyl-activating enzyme (AAE) consensus motif; other site 266264008564 acyl-activating enzyme (AAE) consensus motif; other site 266264008565 putative AMP binding site [chemical binding]; other site 266264008566 putative active site [active] 266264008567 putative CoA binding site [chemical binding]; other site 266264008568 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 266264008569 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266264008570 NAD(P) binding site [chemical binding]; other site 266264008571 active site 266264008572 SAV4209_like. Similar in sequence to the Streptomyces avermitilis SAV4209 protein, with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid...; Region: SAV4209_like; cd03453 266264008573 active site 266264008574 catalytic site [active] 266264008575 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 266264008576 active site 266264008577 catalytic site [active] 266264008578 lipid-transfer protein; Provisional; Region: PRK08256 266264008579 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 266264008580 active site 266264008581 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 266264008582 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 266264008583 active site 266264008584 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 266264008585 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 266264008586 active site 266264008587 lipid-transfer protein; Provisional; Region: PRK08256 266264008588 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 266264008589 active site 266264008590 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 266264008591 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266264008592 NAD(P) binding site [chemical binding]; other site 266264008593 active site 266264008594 ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909 266264008595 AAA ATPase domain; Region: AAA_16; pfam13191 266264008596 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 266264008597 DNA binding residues [nucleotide binding] 266264008598 dimerization interface [polypeptide binding]; other site 266264008599 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 266264008600 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 266264008601 CoA-transferase family III; Region: CoA_transf_3; pfam02515 266264008602 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 266264008603 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 266264008604 trimer interface [polypeptide binding]; other site 266264008605 eyelet of channel; other site 266264008606 Protein of unknown function (DUF2889); Region: DUF2889; pfam11136 266264008607 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 266264008608 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 266264008609 substrate binding pocket [chemical binding]; other site 266264008610 membrane-bound complex binding site; other site 266264008611 hinge residues; other site 266264008612 benzoate transporter; Region: benE; TIGR00843 266264008613 Benzoate membrane transport protein; Region: BenE; pfam03594 266264008614 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 266264008615 Fimbrial protein; Region: Fimbrial; pfam00419 266264008616 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640 266264008617 AAA domain; Region: AAA_22; pfam13401 266264008618 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 266264008619 Walker A motif; other site 266264008620 ATP binding site [chemical binding]; other site 266264008621 Walker B motif; other site 266264008622 arginine finger; other site 266264008623 Integrase core domain; Region: rve; pfam00665 266264008624 Domain of unknown function (DUF4423); Region: DUF4423; pfam14394 266264008625 Protein of unknown function (DUF1376); Region: DUF1376; cl01531 266264008626 insertion element IS2 transposase InsD; Provisional; Region: PRK14702 266264008627 HTH-like domain; Region: HTH_21; pfam13276 266264008628 Integrase core domain; Region: rve; pfam00665 266264008629 Integrase core domain; Region: rve_3; pfam13683 266264008630 Transposase; Region: HTH_Tnp_1; cl17663 266264008631 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 266264008632 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 266264008633 Serine recombinase (SR) family, Partitioning (par)-Resolvase subfamily, catalytic domain; Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining mechanism which involves a transient...; Region: SR_Res_par; cd03767 266264008634 catalytic residues [active] 266264008635 catalytic nucleophile [active] 266264008636 putative transcriptional regulator; Provisional; Region: tfx; cl17550 266264008637 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 266264008638 active site 266264008639 Int/Topo IB signature motif; other site 266264008640 DNA binding site [nucleotide binding] 266264008641 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 266264008642 active site 266264008643 helicase 45; Provisional; Region: PTZ00424 266264008644 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 266264008645 ATP binding site [chemical binding]; other site 266264008646 Mg++ binding site [ion binding]; other site 266264008647 motif III; other site 266264008648 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 266264008649 nucleotide binding region [chemical binding]; other site 266264008650 ATP-binding site [chemical binding]; other site 266264008651 ergothioneine biosynthesis protein EgtB; Region: egtB_TIGR03440 266264008652 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 266264008653 dimethylhistidine N-methyltransferase; Region: egtD_ergothio; TIGR03438 266264008654 Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017 266264008656 integral membrane protein, YjbE family; Region: R_switched_YjbE; TIGR03717 266264008657 thymidylate synthase; Reviewed; Region: thyA; PRK01827 266264008658 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 266264008659 dimerization interface [polypeptide binding]; other site 266264008660 active site 266264008661 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 266264008662 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 266264008663 folate binding site [chemical binding]; other site 266264008664 NADP+ binding site [chemical binding]; other site 266264008665 peptidase PmbA; Provisional; Region: PRK11040 266264008666 hypothetical protein; Provisional; Region: PRK05255 266264008667 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 266264008668 MPT binding site; other site 266264008669 trimer interface [polypeptide binding]; other site 266264008670 Predicted permeases [General function prediction only]; Region: COG0679 266264008671 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 266264008672 catalytic site [active] 266264008673 putative active site [active] 266264008674 putative substrate binding site [chemical binding]; other site 266264008675 dimer interface [polypeptide binding]; other site 266264008676 Peptidase family M48; Region: Peptidase_M48; pfam01435 266264008677 GTPase RsgA; Reviewed; Region: PRK00098 266264008678 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 266264008679 RNA binding site [nucleotide binding]; other site 266264008680 homodimer interface [polypeptide binding]; other site 266264008681 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 266264008682 GTPase/Zn-binding domain interface [polypeptide binding]; other site 266264008683 GTP/Mg2+ binding site [chemical binding]; other site 266264008684 G4 box; other site 266264008685 G5 box; other site 266264008686 G1 box; other site 266264008687 Switch I region; other site 266264008688 G2 box; other site 266264008689 G3 box; other site 266264008690 Switch II region; other site 266264008691 Domain of unknown function (DUF2007); Region: DUF2007; pfam09413 266264008692 CobD/CbiB family protein; Provisional; Region: PRK07630 266264008693 Pirin-related protein [General function prediction only]; Region: COG1741 266264008694 Pirin; Region: Pirin; pfam02678 266264008695 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 266264008696 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266264008697 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 266264008698 dimerization interface [polypeptide binding]; other site 266264008699 Glutamyl- and glutaminyl-tRNA synthetases [Translation, ribosomal structure and biogenesis]; Region: GlnS; COG0008 266264008700 glutamyl-queuosine tRNA(Asp) synthetase; Region: queuosine_YadB; TIGR03838 266264008701 active site 266264008702 HIGH motif; other site 266264008703 nucleotide binding site [chemical binding]; other site 266264008704 active site 266264008705 KMSKS motif; other site 266264008706 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 266264008707 DEAD-like helicases superfamily; Region: DEXDc; smart00487 266264008708 ATP binding site [chemical binding]; other site 266264008709 Mg++ binding site [ion binding]; other site 266264008710 motif III; other site 266264008711 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 266264008712 nucleotide binding region [chemical binding]; other site 266264008713 ATP-binding site [chemical binding]; other site 266264008714 Phosphodiesterase/alkaline phosphatase D [Inorganic ion transport and metabolism]; Region: PhoD; COG3540 266264008715 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 266264008716 Interdomain contacts; other site 266264008717 Cytokine receptor motif; other site 266264008718 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 266264008719 putative active site [active] 266264008720 putative metal binding site [ion binding]; other site 266264008721 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 266264008722 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 266264008723 Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism]; Region: COG4670 266264008724 Coenzyme A transferase; Region: CoA_trans; smart00882 266264008725 Coenzyme A transferase; Region: CoA_trans; cl17247 266264008726 beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431 266264008727 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 266264008728 Bacterial transcriptional regulator; Region: IclR; pfam01614 266264008729 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 266264008730 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 266264008731 C-terminal domain interface [polypeptide binding]; other site 266264008732 GSH binding site (G-site) [chemical binding]; other site 266264008733 dimer interface [polypeptide binding]; other site 266264008734 C-terminal, alpha helical domain of an unknown subfamily 6 of Glutathione S-transferases; Region: GST_C_6; cd03205 266264008735 dimer interface [polypeptide binding]; other site 266264008736 N-terminal domain interface [polypeptide binding]; other site 266264008737 putative substrate binding pocket (H-site) [chemical binding]; other site 266264008738 2-keto-3-deoxygluconate permease; Provisional; Region: PRK05274 266264008739 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395 266264008740 4-hydroxythreonine-4-phosphate dehydrogenase; Reviewed; Region: pdxA; PRK00232 266264008741 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 266264008742 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 266264008743 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 266264008744 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 266264008745 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 266264008746 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 266264008747 homodimer interface [polypeptide binding]; other site 266264008748 active site 266264008749 TDP-binding site; other site 266264008750 acceptor substrate-binding pocket; other site 266264008751 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cl01482 266264008752 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 266264008753 putative CoA-transferase; Provisional; Region: PRK11430 266264008754 CoA-transferase family III; Region: CoA_transf_3; pfam02515 266264008755 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 266264008756 CoA binding domain; Region: CoA_binding_2; pfam13380 266264008757 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 266264008758 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 266264008759 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 266264008760 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 266264008761 active site 266264008762 Transcriptional regulator [Transcription]; Region: IclR; COG1414 266264008763 IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339 266264008764 Bacterial transcriptional regulator; Region: IclR; pfam01614 266264008765 DUF35 OB-fold domain; Region: DUF35; pfam01796 266264008766 lipid-transfer protein; Provisional; Region: PRK08256 266264008767 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 266264008768 active site 266264008769 3-hydroxybutyryl-CoA dehydratase; Validated; Region: PRK05809 266264008770 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 266264008771 substrate binding site [chemical binding]; other site 266264008772 oxyanion hole (OAH) forming residues; other site 266264008773 trimer interface [polypeptide binding]; other site 266264008774 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 266264008775 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266264008776 NAD(P) binding site [chemical binding]; other site 266264008777 active site 266264008778 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 266264008779 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 266264008780 FMN binding site [chemical binding]; other site 266264008781 substrate binding site [chemical binding]; other site 266264008782 putative catalytic residue [active] 266264008783 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 266264008784 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 266264008785 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 266264008786 Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546 266264008787 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 266264008788 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 266264008789 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 266264008790 DNA binding residues [nucleotide binding] 266264008791 DNA primase; Validated; Region: dnaG; PRK05667 266264008792 CHC2 zinc finger; Region: zf-CHC2; pfam01807 266264008793 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 266264008794 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 266264008795 active site 266264008796 metal binding site [ion binding]; metal-binding site 266264008797 interdomain interaction site; other site 266264008798 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 266264008799 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; pfam08278 266264008800 Yqey-like protein; Region: YqeY; pfam09424 266264008801 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 266264008802 HI0933-like protein; Region: HI0933_like; pfam03486 266264008803 UGMP family protein; Validated; Region: PRK09604 266264008804 PhoD-like phosphatase; Region: PhoD; pfam09423 266264008805 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 266264008806 putative active site [active] 266264008807 putative metal binding site [ion binding]; other site 266264008808 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 266264008809 putative GTP cyclohydrolase; Provisional; Region: PRK13674 266264008810 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 266264008811 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 266264008812 TPP-binding site; other site 266264008813 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 266264008814 PYR/PP interface [polypeptide binding]; other site 266264008815 dimer interface [polypeptide binding]; other site 266264008816 TPP binding site [chemical binding]; other site 266264008817 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 266264008818 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 266264008819 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 266264008820 substrate binding pocket [chemical binding]; other site 266264008821 chain length determination region; other site 266264008822 substrate-Mg2+ binding site; other site 266264008823 catalytic residues [active] 266264008824 aspartate-rich region 1; other site 266264008825 active site lid residues [active] 266264008826 aspartate-rich region 2; other site 266264008827 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 266264008828 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 266264008829 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 266264008830 [2Fe-2S] cluster binding site [ion binding]; other site 266264008831 C-terminal catalytic domain of the oxygenase alpha subunit of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C; cd00680 266264008832 alpha subunit interface [polypeptide binding]; other site 266264008833 active site 266264008834 substrate binding site [chemical binding]; other site 266264008835 Fe binding site [ion binding]; other site 266264008836 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 266264008837 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 266264008838 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 266264008839 active site residue [active] 266264008840 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 266264008841 active site residue [active] 266264008842 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428 266264008843 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 266264008844 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 266264008845 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 266264008846 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 266264008847 K+-transporting ATPase, c chain; Region: KdpC; cl00944 266264008848 DNA polymerase I; Provisional; Region: PRK05755 266264008849 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 266264008850 active site 266264008851 metal binding site 1 [ion binding]; metal-binding site 266264008852 putative 5' ssDNA interaction site; other site 266264008853 metal binding site 3; metal-binding site 266264008854 metal binding site 2 [ion binding]; metal-binding site 266264008855 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 266264008856 putative DNA binding site [nucleotide binding]; other site 266264008857 putative metal binding site [ion binding]; other site 266264008858 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 266264008859 active site 266264008860 catalytic site [active] 266264008861 substrate binding site [chemical binding]; other site 266264008862 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 266264008863 active site 266264008864 DNA binding site [nucleotide binding] 266264008865 catalytic site [active] 266264008866 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 266264008867 Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334 266264008868 Homoserine Kinase, type II. Homoserine kinase is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: HomoserineK_II; cd05153 266264008869 putative active site [active] 266264008870 putative substrate binding site [chemical binding]; other site 266264008871 ATP binding site [chemical binding]; other site 266264008872 DNA-dependent helicase II; Provisional; Region: uvrD; PRK11773 266264008873 Part of AAA domain; Region: AAA_19; pfam13245 266264008874 Family description; Region: UvrD_C_2; pfam13538 266264008875 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 266264008876 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 266264008877 HIGH motif; other site 266264008878 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 266264008879 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 266264008880 active site 266264008881 KMSKS motif; other site 266264008882 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 266264008883 tRNA binding surface [nucleotide binding]; other site 266264008884 anticodon binding site; other site 266264008885 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 266264008886 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 266264008887 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 266264008888 active site 266264008889 tetramer interface; other site 266264008890 Uncharacterized protein involved in cation transport [Inorganic ion transport and metabolism]; Region: ChaC; COG3703 266264008891 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 266264008892 putative active site pocket [active] 266264008893 dimerization interface [polypeptide binding]; other site 266264008894 putative catalytic residue [active] 266264008895 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 266264008896 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 266264008897 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 266264008898 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 266264008899 FOG: Ankyrin repeat [General function prediction only]; Region: Arp; COG0666 266264008900 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08314 266264008901 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 266264008902 Putative long-chain fatty acid CoA ligase; Region: LC_FACS_like; cd05935 266264008903 acyl-activating enzyme (AAE) consensus motif; other site 266264008904 putative AMP binding site [chemical binding]; other site 266264008905 putative active site [active] 266264008906 putative CoA binding site [chemical binding]; other site 266264008907 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 266264008908 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 266264008909 catalytic residues [active] 266264008910 Hemerythrin; Region: Hemerythrin; cd12107 266264008911 Fe binding site [ion binding]; other site 266264008912 AAA domain; Region: AAA_33; pfam13671 266264008913 RNA helicase; Region: RNA_helicase; pfam00910 266264008914 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 266264008915 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179 266264008916 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 266264008917 putative ATP binding site [chemical binding]; other site 266264008918 putative substrate interface [chemical binding]; other site 266264008919 Uncharacterized protein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: AsmA; COG2982 266264008920 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 266264008921 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266264008922 Major Facilitator Superfamily; Region: MFS_1; pfam07690 266264008923 putative substrate translocation pore; other site 266264008924 pyridoxamine-phosphate oxidase; Region: pdxH; TIGR00558 266264008925 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 266264008926 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 266264008927 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 266264008928 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 266264008929 S-adenosylmethionine binding site [chemical binding]; other site 266264008930 Protein of unknown function DUF72; Region: DUF72; pfam01904 266264008931 methionine sulfoxide reductase A; Provisional; Region: PRK14054 266264008932 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 266264008933 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 266264008934 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 266264008935 putative DNA binding site [nucleotide binding]; other site 266264008936 putative Zn2+ binding site [ion binding]; other site 266264008937 AsnC family; Region: AsnC_trans_reg; pfam01037 266264008938 Putative cyclase 266264008939 Putative cyclase; Region: Cyclase; cl00814 266264008940 Kynureninase [Amino acid transport and metabolism]; Region: COG3844 266264008941 kynureninase; Region: kynureninase; TIGR01814 266264008942 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 266264008943 catalytic residue [active] 266264008944 tryptophan 2,3-dioxygenase; Region: trp_2_3_diox; TIGR03036 266264008945 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 266264008946 Transcriptional regulator [Transcription]; Region: IclR; COG1414 266264008947 Glutaryl-CoA dehydrogenase; Region: GCD; cd01151 266264008948 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 266264008949 FAD binding site [chemical binding]; other site 266264008950 substrate binding pocket [chemical binding]; other site 266264008951 catalytic base [active] 266264008952 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 266264008953 Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by...; Region: PRX_1cys; cd03016 266264008954 dimer interface [polypeptide binding]; other site 266264008955 decamer (pentamer of dimers) interface [polypeptide binding]; other site 266264008956 catalytic triad [active] 266264008957 Uncharacterized conserved protein [Function unknown]; Region: ElaB; COG4575 266264008958 Predicted membrane protein [Function unknown]; Region: COG5393 266264008959 Protein of unknown function (DUF3318); Region: DUF3318; pfam11780 266264008960 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 266264008961 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 266264008962 metal binding site [ion binding]; metal-binding site 266264008963 active site 266264008964 I-site; other site 266264008965 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 266264008966 PAS fold; Region: PAS_3; pfam08447 266264008967 putative active site [active] 266264008968 heme pocket [chemical binding]; other site 266264008969 D5 N terminal like; Region: D5_N; smart00885 266264008970 phage/plasmid primase, P4 family, C-terminal domain; Region: primase_Cterm; TIGR01613 266264008971 Poxvirus D5 protein-like; Region: Pox_D5; pfam03288 266264008972 McrBC 5-methylcytosine restriction system component; Region: McrBC; cl01737 266264008973 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 266264008974 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 266264008975 Walker A motif; other site 266264008976 ATP binding site [chemical binding]; other site 266264008977 Walker B motif; other site 266264008978 arginine finger; other site 266264008979 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 266264008980 DNA methylase; Region: N6_N4_Mtase; pfam01555 266264008981 DNA methylase; Region: N6_N4_Mtase; cl17433 266264008982 Predicted transporter component [General function prediction only]; Region: COG2391 266264008983 Sulphur transport; Region: Sulf_transp; pfam04143 266264008984 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 266264008985 Ligand Binding Site [chemical binding]; other site 266264008986 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 266264008987 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 266264008988 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 266264008989 ligand binding site [chemical binding]; other site 266264008990 translocation protein TolB; Provisional; Region: tolB; PRK02889 266264008991 TolB amino-terminal domain; Region: TolB_N; pfam04052 266264008992 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 266264008993 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 266264008994 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 266264008995 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 266264008996 TolA protein; Region: tolA_full; TIGR02794 266264008997 TonB C terminal; Region: TonB_2; pfam13103 266264008998 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 266264008999 TolR protein; Region: tolR; TIGR02801 266264009000 TolQ protein; Region: tolQ; TIGR02796 266264009001 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 266264009002 active site 266264009003 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 266264009004 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 266264009005 dimer interface [polypeptide binding]; other site 266264009006 active site 266264009007 glycine-pyridoxal phosphate binding site [chemical binding]; other site 266264009008 folate binding site [chemical binding]; other site 266264009009 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 266264009010 ATP cone domain; Region: ATP-cone; pfam03477 266264009011 Tfp pilus assembly protein PilW [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilW; COG4966 266264009012 Tfp pilus assembly protein PilX [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilX; COG4726 266264009013 Tfp pilus assembly protein, tip-associated adhesin PilY1 [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilY1; COG3419 266264009014 Tfp pilus assembly protein PilE [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilE; COG4968 266264009015 bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase; Provisional; Region: ribD; PRK10786 266264009016 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 266264009017 catalytic motif [active] 266264009018 Zn binding site [ion binding]; other site 266264009019 RibD C-terminal domain; Region: RibD_C; cl17279 266264009020 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 266264009021 Lumazine binding domain; Region: Lum_binding; pfam00677 266264009022 Lumazine binding domain; Region: Lum_binding; pfam00677 266264009023 Putative motility protein; Region: YjfB_motility; pfam14070 266264009024 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 266264009025 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 266264009026 CoA-transferase family III; Region: CoA_transf_3; pfam02515 266264009027 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II-like protein; Provisional; Region: PRK14019 266264009028 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 266264009029 GTP cyclohydrolase II; Region: GTP_cyclohydro2; pfam00925 266264009030 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 266264009031 homopentamer interface [polypeptide binding]; other site 266264009032 active site 266264009033 transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202 266264009034 putative RNA binding site [nucleotide binding]; other site 266264009035 aminotransferase; Validated; Region: PRK07337 266264009036 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 266264009037 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266264009038 homodimer interface [polypeptide binding]; other site 266264009039 catalytic residue [active] 266264009040 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 266264009041 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 266264009042 N-acetyl-D-glucosamine binding site [chemical binding]; other site 266264009043 catalytic residue [active] 266264009044 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; cl00311 266264009045 acetoacetyl-CoA synthetase; Provisional; Region: PRK03584 266264009046 Acetoacetyl-CoA synthetase (acetoacetate-CoA ligase, AACS); Region: AACS; cd05943 266264009047 acyl-activating enzyme (AAE) consensus motif; other site 266264009048 putative AMP binding site [chemical binding]; other site 266264009049 putative active site [active] 266264009050 putative CoA binding site [chemical binding]; other site 266264009051 GST_N family, unknown subfamily 1; composed of uncharacterized proteins, predominantly from bacteria, with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with...; Region: GST_N_1; cd03043 266264009052 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 266264009053 putative C-terminal domain interface [polypeptide binding]; other site 266264009054 putative GSH binding site (G-site) [chemical binding]; other site 266264009055 putative dimer interface [polypeptide binding]; other site 266264009056 C-terminal, alpha helical domain of an unknown subfamily 3 of Glutathione S-transferases; Region: GST_C_3; cd03194 266264009057 putative N-terminal domain interface [polypeptide binding]; other site 266264009058 putative dimer interface [polypeptide binding]; other site 266264009059 putative substrate binding pocket (H-site) [chemical binding]; other site 266264009060 polyhydroxyalkanoate depolymerase, intracellular; Region: PHB_depoly_PhaZ; TIGR01849 266264009061 PHB de-polymerase C-terminus; Region: PHB_depo_C; pfam06850 266264009062 aldose 1-epimerase superfamily; Region: Aldose_epim; cl14648 266264009063 active site 266264009064 catalytic residues [active] 266264009065 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 266264009066 S-adenosylmethionine binding site [chemical binding]; other site 266264009067 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 266264009068 Protein of unknown function (DUF1439); Region: DUF1439; cl06345 266264009069 Flagellin N-methylase; Region: FliB; cl00497 266264009070 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 266264009071 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 266264009072 Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518 266264009073 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 266264009074 S-adenosylmethionine binding site [chemical binding]; other site 266264009075 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 266264009076 active site residue [active] 266264009077 outer membrane channel protein; Reviewed; Region: tolC; PRK09465 266264009078 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 266264009079 O-Antigen ligase; Region: Wzy_C; pfam04932 266264009080 META domain; Region: META; pfam03724 266264009081 Domain of unknown function (DUF4377); Region: DUF4377; pfam14302 266264009082 3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749 266264009083 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 266264009084 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 266264009085 Glycosyltransferase family 9 (heptosyltransferase); Region: Glyco_transf_9; pfam01075 266264009086 putative active site [active] 266264009087 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 266264009088 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 266264009089 active site 266264009090 substrate binding site [chemical binding]; other site 266264009091 metal binding site [ion binding]; metal-binding site 266264009092 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 266264009093 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 266264009094 putative ADP-binding pocket [chemical binding]; other site 266264009095 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 266264009096 Bacterial sugar transferase; Region: Bac_transf; pfam02397 266264009097 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 266264009098 This family is most closely related to the GT1 family of glycosyltransferases and is named after WbdM in Escherichia coli. In general glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor...; Region: GT1_WbdM_like; cd04951 266264009099 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 266264009100 This family is most closely related to the GT1 family of glycosyltransferases. AmSD in Erwinia amylovora has been shown to be involved in the biosynthesis of amylovoran, the acidic exopolysaccharide acting as a virulence factor. This enzyme may be...; Region: GT1_amsD_like; cd03820 266264009101 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 266264009102 putative ADP-binding pocket [chemical binding]; other site 266264009103 Chain length determinant protein; Region: Wzz; pfam02706 266264009104 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 266264009105 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 266264009106 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 266264009107 NAD(P) binding site [chemical binding]; other site 266264009108 homodimer interface [polypeptide binding]; other site 266264009109 substrate binding site [chemical binding]; other site 266264009110 active site 266264009111 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 266264009112 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 266264009113 inhibitor-cofactor binding pocket; inhibition site 266264009114 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266264009115 catalytic residue [active] 266264009116 Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360 266264009117 sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570 266264009118 putative trimer interface [polypeptide binding]; other site 266264009119 putative CoA binding site [chemical binding]; other site 266264009120 hypothetical protein 266264009121 Bacterial sugar transferase; Region: Bac_transf; pfam02397 266264009122 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 266264009123 PEP-CTERM/exosortase A-associated glycosyltransferase, Daro_2409 family; Region: stp3; TIGR04063 266264009124 putative ADP-binding pocket [chemical binding]; other site 266264009125 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 266264009126 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 266264009127 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 266264009128 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 266264009129 active site 266264009130 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 266264009131 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 266264009132 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 266264009133 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: rmlC; TIGR01221 266264009134 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 266264009135 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 266264009136 substrate binding site; other site 266264009137 tetramer interface; other site 266264009138 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 266264009139 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 266264009140 NADP binding site [chemical binding]; other site 266264009141 active site 266264009142 putative substrate binding site [chemical binding]; other site 266264009143 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 266264009144 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 266264009145 NAD binding site [chemical binding]; other site 266264009146 substrate binding site [chemical binding]; other site 266264009147 homodimer interface [polypeptide binding]; other site 266264009148 active site 266264009149 diadenosine tetraphosphatase; Reviewed; Region: apaH; PRK00166 266264009150 Escherichia coli ApaH and related proteins, metallophosphatase domain; Region: MPP_ApaH; cd07422 266264009151 active site 266264009152 metal binding site [ion binding]; metal-binding site 266264009153 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 266264009154 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 266264009155 putative acyl-acceptor binding pocket; other site 266264009156 dihydroorotase; Provisional; Region: PRK07627 266264009157 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 266264009158 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 266264009159 active site 266264009160 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 266264009161 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 266264009162 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 266264009163 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 266264009164 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 266264009165 active site 266264009166 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 266264009167 hypothetical protein; Validated; Region: PRK00228 266264009168 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 266264009169 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 266264009170 RNA binding surface [nucleotide binding]; other site 266264009171 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 266264009172 active site 266264009173 uracil binding [chemical binding]; other site 266264009174 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 266264009175 DNA photolyase; Region: DNA_photolyase; pfam00875 266264009176 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 266264009177 heme biosynthesis-associated TPR protein; Region: TPR_hemY_coli; TIGR00540 266264009178 HemY protein N-terminus; Region: HemY_N; pfam07219 266264009179 bifunctional uroporphyrinogen-III synthetase/uroporphyrin-III C-methyltransferase; Reviewed; Region: PRK06975 266264009180 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 266264009181 active site 266264009182 putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920 266264009183 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 266264009184 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708 266264009185 domain interfaces; other site 266264009186 active site 266264009187 phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009 266264009188 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 266264009189 argininosuccinate lyase; Provisional; Region: PRK00855 266264009190 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 266264009191 active sites [active] 266264009192 tetramer interface [polypeptide binding]; other site 266264009193 TRAP-type mannitol/chloroaromatic compound transport system, small permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT2; COG4665 266264009194 TRAP-type mannitol/chloroaromatic compound transport system, large permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT3; COG4664 266264009195 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 266264009196 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 266264009197 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 266264009198 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 266264009199 catalytic residue [active] 266264009200 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 266264009201 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 266264009202 trimer interface [polypeptide binding]; other site 266264009203 active site 266264009204 FdhD/NarQ family; Region: FdhD-NarQ; pfam02634 266264009205 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 266264009206 E-class dimer interface [polypeptide binding]; other site 266264009207 P-class dimer interface [polypeptide binding]; other site 266264009208 active site 266264009209 Cu2+ binding site [ion binding]; other site 266264009210 Zn2+ binding site [ion binding]; other site 266264009211 Cytochrome b subunit of formate dehydrogenase [Energy production and conversion]; Region: FdnI; COG2864 266264009212 formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583 266264009213 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 266264009214 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 266264009215 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 266264009216 [4Fe-4S] binding site [ion binding]; other site 266264009217 molybdopterin cofactor binding site; other site 266264009218 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 266264009219 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 266264009220 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 266264009221 molybdopterin cofactor binding site; other site 266264009222 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 266264009223 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 266264009224 4Fe-4S binding domain; Region: Fer4_6; pfam12837 266264009225 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 266264009226 4Fe-4S binding domain; Region: Fer4; pfam00037 266264009227 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 266264009228 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 266264009229 Protein of unknown function (DUF3306); Region: DUF3306; pfam11748 266264009230 Protein of unknown function (DUF3305); Region: DUF3305; pfam11749 266264009231 antiporter inner membrane protein; Provisional; Region: PRK11670 266264009232 Domain of unknown function DUF59; Region: DUF59; pfam01883 266264009233 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 266264009234 Walker A motif; other site 266264009235 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 266264009236 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 266264009237 ligand binding site [chemical binding]; other site 266264009238 methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133 266264009239 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 266264009240 active site 266264009241 HIGH motif; other site 266264009242 KMSKS motif; other site 266264009243 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 266264009244 tRNA binding surface [nucleotide binding]; other site 266264009245 anticodon binding site; other site 266264009246 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 266264009247 dimer interface [polypeptide binding]; other site 266264009248 putative tRNA-binding site [nucleotide binding]; other site 266264009249 SmpA / OmlA family; Region: SmpA_OmlA; pfam04355 266264009250 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911 266264009251 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 266264009252 Family of unknown function (DUF490); Region: DUF490; pfam04357 266264009253 Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729 266264009254 Surface antigen; Region: Bac_surface_Ag; pfam01103 266264009255 Protein of unknown function (DUF3460); Region: DUF3460; pfam11943 266264009256 Rec8/ScpA/Scc1-like protein (kleisin family) [Replication, recombination, and repair]; Region: scpA; COG1354 266264009257 pantoate--beta-alanine ligase; Region: panC; TIGR00018 266264009258 Pantoate-beta-alanine ligase; Region: PanC; cd00560 266264009259 active site 266264009260 ATP-binding site [chemical binding]; other site 266264009261 pantoate-binding site; other site 266264009262 HXXH motif; other site 266264009263 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 266264009264 PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172 266264009265 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 266264009266 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 266264009267 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 266264009268 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 266264009269 Coenzyme A binding pocket [chemical binding]; other site 266264009270 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 266264009271 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 266264009272 P-loop; other site 266264009273 Magnesium ion binding site [ion binding]; other site 266264009274 cobyric acid synthase; Provisional; Region: PRK00784 266264009275 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 266264009276 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 266264009277 catalytic triad [active] 266264009278 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 266264009279 homotrimer interface [polypeptide binding]; other site 266264009280 Walker A motif; other site 266264009281 GTP binding site [chemical binding]; other site 266264009282 Walker B motif; other site 266264009283 cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209 266264009284 L-threonine-O-3-phosphate decarboxylase; Region: L_thr_O3P_dcar; TIGR01140 266264009285 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 266264009286 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266264009287 homodimer interface [polypeptide binding]; other site 266264009288 catalytic residue [active] 266264009289 vitamin B12-transporter protein BtuF; Provisional; Region: PRK03379 266264009290 Cobalamin binding protein BtuF. These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species. They belong to the TroA superfamily of helical backbone metal receptor...; Region: BtuF; cd01144 266264009291 cobalamin binding residues [chemical binding]; other site 266264009292 putative BtuC binding residues; other site 266264009293 dimer interface [polypeptide binding]; other site 266264009294 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 266264009295 catalytic core [active] 266264009296 cobalamin synthase; Reviewed; Region: cobS; PRK00235 266264009297 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 266264009298 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 266264009299 active site pocket [active] 266264009300 putative dimer interface [polypeptide binding]; other site 266264009301 putative cataytic base [active] 266264009302 Cob(I)alamin adenosyltransferase N terminal; Region: Co_AT_N; pfam12557 266264009303 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 266264009304 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 266264009305 homodimer interface [polypeptide binding]; other site 266264009306 Walker A motif; other site 266264009307 ATP binding site [chemical binding]; other site 266264009308 hydroxycobalamin binding site [chemical binding]; other site 266264009309 Walker B motif; other site 266264009310 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 266264009311 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 266264009312 Walker A/P-loop; other site 266264009313 ATP binding site [chemical binding]; other site 266264009314 Q-loop/lid; other site 266264009315 ABC transporter signature motif; other site 266264009316 Walker B; other site 266264009317 D-loop; other site 266264009318 H-loop/switch region; other site 266264009319 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 266264009320 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 266264009321 ABC-ATPase subunit interface; other site 266264009322 dimer interface [polypeptide binding]; other site 266264009323 putative PBP binding regions; other site 266264009324 Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206 266264009325 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 266264009326 N-terminal plug; other site 266264009327 ligand-binding site [chemical binding]; other site 266264009329 Cell division protein ZapA; Region: ZapA; pfam05164 266264009330 Uncharacterized conserved protein [Function unknown]; Region: COG2947 266264009331 Protein of unknown function (DUF541); Region: SIMPL; cl01077 266264009332 malonyl-CoA synthase; Validated; Region: PRK07514 266264009333 Malonyl-CoA synthetase (MCS); Region: MCS; cd05941 266264009334 acyl-activating enzyme (AAE) consensus motif; other site 266264009335 active site 266264009336 AMP binding site [chemical binding]; other site 266264009337 CoA binding site [chemical binding]; other site 266264009338 enoyl-CoA hydratase; Provisional; Region: PRK06127 266264009339 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 266264009340 substrate binding site [chemical binding]; other site 266264009341 oxyanion hole (OAH) forming residues; other site 266264009342 trimer interface [polypeptide binding]; other site 266264009343 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 266264009344 Malonyl-CoA decarboxylase (MCD); Region: MCD; pfam05292 266264009345 Transcriptional regulators [Transcription]; Region: GntR; COG1802 266264009346 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266264009347 DNA-binding site [nucleotide binding]; DNA binding site 266264009348 FCD domain; Region: FCD; pfam07729 266264009349 Bacterial protein of unknown function (DUF898); Region: DUF898; pfam05987 266264009350 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 266264009351 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 266264009352 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266264009353 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266264009354 The C-terminal substrate binding domain of LysR-type transcriptional regulator, IlvR, involved in the biosynthesis of isoleucine, leucine and valine; contains type 2 periplasmic binding fold; Region: PBP2_IlvR; cd08453 266264009355 putative dimerization interface [polypeptide binding]; other site 266264009356 putative substrate binding pocket [chemical binding]; other site 266264009357 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 266264009358 DNA polymerase III subunit chi; Validated; Region: PRK05728 266264009359 multifunctional aminopeptidase A; Provisional; Region: PRK00913 266264009360 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 266264009361 interface (dimer of trimers) [polypeptide binding]; other site 266264009362 Substrate-binding/catalytic site; other site 266264009363 Zn-binding sites [ion binding]; other site 266264009364 Predicted permeases [General function prediction only]; Region: COG0795 266264009365 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 266264009366 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 266264009367 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 266264009368 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 266264009369 putative active site [active] 266264009370 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 266264009371 active site 266264009372 SAM binding site [chemical binding]; other site 266264009373 homodimer interface [polypeptide binding]; other site 266264009374 GTPases - Sulfate adenylate transferase subunit 1 [Inorganic ion transport and metabolism]; Region: CysN; COG2895 266264009375 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 266264009376 CysD dimerization site [polypeptide binding]; other site 266264009377 G1 box; other site 266264009378 putative GEF interaction site [polypeptide binding]; other site 266264009379 GTP/Mg2+ binding site [chemical binding]; other site 266264009380 Switch I region; other site 266264009381 G2 box; other site 266264009382 G3 box; other site 266264009383 Switch II region; other site 266264009384 G4 box; other site 266264009385 G5 box; other site 266264009386 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 266264009387 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 266264009388 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 266264009389 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 266264009390 Active Sites [active] 266264009391 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 266264009392 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 266264009393 Active Sites [active] 266264009394 Bacterial protein of unknown function (DUF934); Region: DUF934; pfam06073 266264009395 Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155 266264009396 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 266264009397 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 266264009398 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 266264009399 transcriptional regulator CysB-like protein; Reviewed; Region: PRK12684 266264009400 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266264009401 The C-terminal substrate domain of LysR-type transcriptional regulators CysB-like contains type 2 periplasmic binding fold; Region: PBP2_CysB_like; cd08413 266264009402 substrate binding site [chemical binding]; other site 266264009403 dimerization interface [polypeptide binding]; other site 266264009404 Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis]; Region: HemK; COG2890 266264009405 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 266264009406 S-adenosylmethionine binding site [chemical binding]; other site 266264009407 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 266264009408 Type I periplasmic binding component of ABC (ATPase Binding Cassette)-type transport systems that are predicted to be involved in uptake of amino acids; Region: PBP1_ABC-type_HAAT_like; cd06333 266264009409 putative ligand binding site [chemical binding]; other site 266264009410 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 266264009411 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 266264009412 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 266264009413 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 266264009414 HNH endonuclease; Region: HNH; pfam01844 266264009415 active site 266264009416 Plasmid encoded RepA protein; Region: RepA_C; pfam04796 266264009417 conjugal transfer/type IV secretion protein DotA/TraY; Region: DotA_TraY; TIGR04346 266264009418 DNA methylase; Region: N6_N4_Mtase; cl17433 266264009419 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 266264009420 non-specific DNA binding site [nucleotide binding]; other site 266264009421 salt bridge; other site 266264009422 sequence-specific DNA binding site [nucleotide binding]; other site 266264009423 P-loop containing region of AAA domain; Region: AAA_29; cl17516 266264009424 AAA domain; Region: AAA_23; pfam13476 266264009425 Relaxase/mobilization nuclease topoisomerase/primase fusion protein (fragment) 266264009426 AAA domain; Region: AAA_22; pfam13401 266264009427 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 266264009428 Walker A motif; other site 266264009429 ATP binding site [chemical binding]; other site 266264009430 Walker B motif; other site 266264009431 arginine finger; other site 266264009432 Integrase core domain; Region: rve; pfam00665 266264009433 relaxase/mobilization nuclease domain-containing protein (fragment)(CMGI-5) 266264009434 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 266264009435 Helix-turn-helix domain; Region: HTH_38; pfam13936 266264009436 Integrase core domain; Region: rve; pfam00665 266264009437 conserved hypothetical protein 266264009438 hypothetical protein 266264009439 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; pfam04014 266264009440 Domain of unknown function DUF29; Region: DUF29; pfam01724 266264009441 putative transcriptional regulator (fragment) 266264009442 DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins; Region: ERI-1_3'hExo_like; cd06133 266264009443 active site 266264009444 catalytic site [active] 266264009445 substrate binding site [chemical binding]; other site 266264009446 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 266264009447 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 266264009448 active site 266264009449 DNA binding site [nucleotide binding] 266264009450 Int/Topo IB signature motif; other site 266264009451 Outer membrane autotransporter barrel (fragment) 266264009452 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 266264009453 N-formylglutamate amidohydrolase; Region: FGase; cl01522 266264009454 N-formimino-L-glutamate deiminase; Validated; Region: PRK09229 266264009455 Metallo-dependent hydrolases, subgroup D is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_E; cd01313 266264009456 active site 266264009457 imidazolonepropionase; Validated; Region: PRK09356 266264009458 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 266264009459 active site 266264009460 HutD; Region: HutD; pfam05962 266264009461 urocanate hydratase; Provisional; Region: PRK05414 266264009462 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 266264009463 active sites [active] 266264009464 tetramer interface [polypeptide binding]; other site 266264009465 histidine utilization repressor, proteobacterial; Region: his_ut_repres; TIGR02018 266264009466 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266264009467 DNA-binding site [nucleotide binding]; DNA binding site 266264009468 UTRA domain; Region: UTRA; pfam07702 266264009469 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 266264009470 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 266264009471 Walker A/P-loop; other site 266264009472 ATP binding site [chemical binding]; other site 266264009473 Q-loop/lid; other site 266264009474 ABC transporter signature motif; other site 266264009475 Walker B; other site 266264009476 D-loop; other site 266264009477 H-loop/switch region; other site 266264009478 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 266264009479 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266264009480 dimer interface [polypeptide binding]; other site 266264009481 conserved gate region; other site 266264009482 putative PBP binding loops; other site 266264009483 ABC-ATPase subunit interface; other site 266264009484 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 266264009485 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 266264009486 substrate binding pocket [chemical binding]; other site 266264009487 membrane-bound complex binding site; other site 266264009488 hinge residues; other site 266264009489 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266264009490 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 266264009491 NAD(P) binding site [chemical binding]; other site 266264009492 active site 266264009493 CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated; Region: PRK07609 266264009494 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 266264009495 catalytic loop [active] 266264009496 iron binding site [ion binding]; other site 266264009497 NAD(P)H dependent flavin oxidoreductases use flavin as a substrate in mediating electron transfer from iron complexes or iron proteins. Structurally similar to ferredoxin reductases, but with only 15% sequence identity, flavin reductases reduce FAD, FMN; Region: flavin_oxioreductase; cd06189 266264009498 FAD binding pocket [chemical binding]; other site 266264009499 FAD binding motif [chemical binding]; other site 266264009500 phosphate binding motif [ion binding]; other site 266264009501 beta-alpha-beta structure motif; other site 266264009502 NAD binding pocket [chemical binding]; other site 266264009503 acetylornithine transaminase protein; Provisional; Region: argD; PRK03715 266264009504 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 266264009505 inhibitor-cofactor binding pocket; inhibition site 266264009506 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266264009507 catalytic residue [active] 266264009508 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 266264009509 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 266264009510 Walker A/P-loop; other site 266264009511 ATP binding site [chemical binding]; other site 266264009512 Q-loop/lid; other site 266264009513 ABC transporter signature motif; other site 266264009514 Walker B; other site 266264009515 D-loop; other site 266264009516 H-loop/switch region; other site 266264009517 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 266264009518 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 266264009519 Walker A/P-loop; other site 266264009520 ATP binding site [chemical binding]; other site 266264009521 Q-loop/lid; other site 266264009522 ABC transporter signature motif; other site 266264009523 Walker B; other site 266264009524 D-loop; other site 266264009525 H-loop/switch region; other site 266264009526 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 266264009527 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 266264009528 TM-ABC transporter signature motif; other site 266264009529 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 266264009530 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 266264009531 TM-ABC transporter signature motif; other site 266264009532 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 266264009533 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 266264009534 dimerization interface [polypeptide binding]; other site 266264009535 ligand binding site [chemical binding]; other site 266264009536 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 266264009537 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 266264009538 FKBP-type peptidyl-prolyl cis-trans isomerases 2 [Posttranslational modification, protein turnover, chaperones]; Region: SlpA; COG1047 266264009539 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 266264009540 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 266264009541 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 266264009542 L-aspartate oxidase; Provisional; Region: PRK09077 266264009543 L-aspartate oxidase; Provisional; Region: PRK06175 266264009544 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 266264009545 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK06978 266264009546 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 266264009547 dimerization interface [polypeptide binding]; other site 266264009548 active site 266264009549 quinolinate synthetase; Provisional; Region: PRK09375 266264009550 Fatty acid desaturase; Region: FA_desaturase; pfam00487 266264009551 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 266264009552 Di-iron ligands [ion binding]; other site 266264009553 Transposase; Region: DDE_Tnp_ISL3; pfam01610 266264009554 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: COG3264 266264009555 Mechanosensitive ion channel; Region: MS_channel; pfam00924 266264009556 NOL1/NOP2/sun family; Region: Nol1_Nop2_Fmu; pfam01189 266264009557 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 266264009558 S-adenosylmethionine binding site [chemical binding]; other site 266264009559 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 266264009560 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 266264009561 active site 266264009562 substrate binding site [chemical binding]; other site 266264009563 cosubstrate binding site; other site 266264009564 catalytic site [active] 266264009565 Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006 266264009566 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 266264009567 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 266264009568 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266264009569 active site 266264009570 phosphorylation site [posttranslational modification] 266264009571 intermolecular recognition site; other site 266264009572 dimerization interface [polypeptide binding]; other site 266264009573 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 266264009574 DNA binding residues [nucleotide binding] 266264009575 dimerization interface [polypeptide binding]; other site 266264009576 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 266264009577 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 266264009578 dimer interface [polypeptide binding]; other site 266264009579 phosphorylation site [posttranslational modification] 266264009580 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266264009581 ATP binding site [chemical binding]; other site 266264009582 Mg2+ binding site [ion binding]; other site 266264009583 G-X-G motif; other site 266264009584 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 266264009585 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266264009586 active site 266264009587 phosphorylation site [posttranslational modification] 266264009588 intermolecular recognition site; other site 266264009589 dimerization interface [polypeptide binding]; other site 266264009590 N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655 266264009591 Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344 266264009592 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 266264009593 putative active site [active] 266264009594 putative NTP binding site [chemical binding]; other site 266264009595 putative nucleic acid binding site [nucleotide binding]; other site 266264009596 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 266264009597 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 266264009598 active site 266264009599 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 266264009600 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 266264009601 active site 266264009602 Riboflavin kinase; Region: Flavokinase; smart00904 266264009603 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 266264009604 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 266264009605 active site 266264009606 HIGH motif; other site 266264009607 nucleotide binding site [chemical binding]; other site 266264009608 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 266264009609 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 266264009610 active site 266264009611 KMSKS motif; other site 266264009612 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 266264009613 tRNA binding surface [nucleotide binding]; other site 266264009614 anticodon binding site; other site 266264009615 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 266264009616 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 266264009617 lipoprotein signal peptidase; Provisional; Region: PRK14787 266264009618 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 266264009619 Flavoprotein; Region: Flavoprotein; pfam02441 266264009620 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 266264009621 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 266264009622 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 266264009623 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 266264009624 trimer interface [polypeptide binding]; other site 266264009625 active site 266264009626 Glyoxalase-like domain; Region: Glyoxalase_3; pfam13468 266264009627 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 266264009628 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 266264009629 ATP-dependent Clp protease ATP-binding subunit clpA; Region: ClpA; TIGR02639 266264009630 Clp amino terminal domain; Region: Clp_N; pfam02861 266264009631 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 266264009632 Walker A motif; other site 266264009633 ATP binding site [chemical binding]; other site 266264009634 Walker B motif; other site 266264009635 arginine finger; other site 266264009636 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 266264009637 Walker A motif; other site 266264009638 ATP binding site [chemical binding]; other site 266264009639 Walker B motif; other site 266264009640 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 266264009641 Uncharacterized conserved protein [Function unknown]; Region: COG2127 266264009642 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 266264009643 DNA-binding site [nucleotide binding]; DNA binding site 266264009644 RNA-binding motif; other site 266264009645 isocitrate dehydrogenase; Validated; Region: PRK07362 266264009646 isocitrate dehydrogenase; Reviewed; Region: PRK07006 266264009647 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 266264009648 pseudouridine synthase; Region: TIGR00093 266264009649 active site 266264009650 Uncharacterized ACR, COG1430; Region: DUF192; pfam02643 266264009651 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 266264009652 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 266264009653 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK00046 266264009654 FAD binding domain; Region: FAD_binding_4; pfam01565 266264009655 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 266264009656 Protein of unknown function (DUF1255); Region: DUF1255; pfam06865 266264009657 ornithine carbamoyltransferase; Provisional; Region: PRK00779 266264009658 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 266264009659 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 266264009660 conserved hypothetical protein 266264009661 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 266264009662 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 266264009663 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 266264009664 Uncharacterized conserved protein [Function unknown]; Region: COG2912 266264009665 Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369 266264009666 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 266264009667 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 266264009668 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 266264009669 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266264009670 ATP binding site [chemical binding]; other site 266264009671 Mg2+ binding site [ion binding]; other site 266264009672 G-X-G motif; other site 266264009673 Domain of unknown function (DUF3328); Region: DUF3328; pfam11807 266264009674 MutL_Trans_MutL: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to Escherichia coli MutL. EcMutL belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second...; Region: MutL_Trans_MutL; cd03482 266264009675 ATP binding site [chemical binding]; other site 266264009676 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 266264009677 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 266264009678 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 266264009679 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 266264009680 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 266264009681 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 266264009682 dimerization interface [polypeptide binding]; other site 266264009683 putative ATP binding site [chemical binding]; other site 266264009684 DnaA regulatory inactivator Hda; Validated; Region: PRK08903 266264009685 ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593 266264009686 Walker A motif; other site 266264009687 ATP binding site [chemical binding]; other site 266264009688 Walker B motif; other site 266264009689 arginine finger; other site 266264009690 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 266264009691 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 266264009692 poly(A) polymerase; Region: pcnB; TIGR01942 266264009693 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 266264009694 active site 266264009695 NTP binding site [chemical binding]; other site 266264009696 metal binding triad [ion binding]; metal-binding site 266264009697 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 266264009698 Polymerase A arginine-rich C-terminus; Region: PolyA_pol_arg_C; pfam12626 266264009699 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 266264009700 catalytic center binding site [active] 266264009701 ATP binding site [chemical binding]; other site 266264009702 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 266264009703 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 266264009704 Substrate-binding site [chemical binding]; other site 266264009705 Substrate specificity [chemical binding]; other site 266264009706 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 266264009707 oligomerization interface [polypeptide binding]; other site 266264009708 active site 266264009709 metal binding site [ion binding]; metal-binding site 266264009710 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266264009711 dimer interface [polypeptide binding]; other site 266264009712 conserved gate region; other site 266264009713 putative PBP binding loops; other site 266264009714 ABC-ATPase subunit interface; other site 266264009715 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 266264009716 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 266264009717 Walker A/P-loop; other site 266264009718 ATP binding site [chemical binding]; other site 266264009719 Q-loop/lid; other site 266264009720 ABC transporter signature motif; other site 266264009721 Walker B; other site 266264009722 D-loop; other site 266264009723 H-loop/switch region; other site 266264009724 aminodeoxychorismate synthase, component I, clade 2; Region: PabB-clade2; TIGR01824 266264009725 chorismate binding enzyme; Region: Chorismate_bind; cl10555 266264009726 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224 266264009727 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 266264009728 homodimer interface [polypeptide binding]; other site 266264009729 substrate-cofactor binding pocket; other site 266264009730 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266264009731 catalytic residue [active] 266264009732 chaperone protein DnaJ; Provisional; Region: PRK10767 266264009733 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 266264009734 HSP70 interaction site [polypeptide binding]; other site 266264009735 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 266264009736 substrate binding site [polypeptide binding]; other site 266264009737 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 266264009738 Zn binding sites [ion binding]; other site 266264009739 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 266264009740 dimer interface [polypeptide binding]; other site 266264009741 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 266264009742 Nucleotide-binding domain of human HSPA9, Escherichia coli DnaK, and similar proteins; Region: HSPA9-like_NBD; cd11733 266264009743 nucleotide binding site [chemical binding]; other site 266264009744 NEF interaction site [polypeptide binding]; other site 266264009745 SBD interface [polypeptide binding]; other site 266264009746 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; cl00920 266264009747 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 266264009748 FAD binding domain; Region: FAD_binding_4; pfam01565 266264009749 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 266264009750 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266264009751 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 266264009752 dimerization interface [polypeptide binding]; other site 266264009753 substrate binding pocket [chemical binding]; other site 266264009754 glycolate oxidase subunit GlcD; Provisional; Region: PRK11230 266264009755 FAD binding domain; Region: FAD_binding_4; pfam01565 266264009756 Ion transport protein; Region: Ion_trans; pfam00520 266264009757 Ion channel; Region: Ion_trans_2; pfam07885 266264009758 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 266264009759 Double zinc ribbon; Region: DZR; pfam12773 266264009760 glycolate oxidase FAD binding subunit; Provisional; Region: glcE; PRK11282 266264009761 FAD binding domain; Region: FAD_binding_4; pfam01565 266264009762 glycolate oxidase iron-sulfur subunit; Provisional; Region: glcF; PRK11274 266264009763 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 266264009764 Cysteine-rich domain; Region: CCG; pfam02754 266264009765 Cysteine-rich domain; Region: CCG; pfam02754 266264009766 LrgA family; Region: LrgA; pfam03788 266264009767 Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346 266264009768 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 266264009769 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 266264009770 Predicted transcriptional regulator [Transcription]; Region: COG2378 266264009771 HTH domain; Region: HTH_11; pfam08279 266264009772 WYL domain; Region: WYL; pfam13280 266264009773 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 266264009774 catalytic residues [active] 266264009775 dimer interface [polypeptide binding]; other site 266264009776 Tfp pilus assembly protein, ATPase PilU [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilU; COG5008 266264009777 Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131 266264009778 Walker A motif; other site 266264009779 ATP binding site [chemical binding]; other site 266264009780 Walker B motif; other site 266264009781 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 266264009782 Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131 266264009783 Walker A motif; other site 266264009784 ATP binding site [chemical binding]; other site 266264009785 Walker B motif; other site 266264009786 Pyridoxal 5-phosphate (PLP)-binding TIM barrel domain of Type III PLP-Dependent Enzymes, Yggs-like proteins; Region: PLPDE_III_Yggs_like; cd06824 266264009787 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 266264009788 catalytic residue [active] 266264009789 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 266264009790 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 266264009791 4-hydroxybenzoate octaprenyltransferase; Reviewed; Region: ubiA; PRK12848 266264009792 UbiA prenyltransferase family; Region: UbiA; pfam01040 266264009793 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 266264009794 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 266264009795 dimerization interface [polypeptide binding]; other site 266264009796 DPS ferroxidase diiron center [ion binding]; other site 266264009797 ion pore; other site 266264009798 conserved hypothetical protein 266264009799 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 266264009800 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266264009801 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 266264009802 dimerization interface [polypeptide binding]; other site 266264009803 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 266264009804 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 266264009805 generic binding surface II; other site 266264009806 ssDNA binding site; other site 266264009807 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 266264009808 ATP binding site [chemical binding]; other site 266264009809 putative Mg++ binding site [ion binding]; other site 266264009810 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 266264009811 nucleotide binding region [chemical binding]; other site 266264009812 ATP-binding site [chemical binding]; other site 266264009813 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 266264009814 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 266264009815 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 266264009816 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 266264009817 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585 266264009818 SecD export protein N-terminal TM region; Region: SecD-TM1; pfam13721 266264009819 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 266264009820 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 266264009821 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 266264009822 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 266264009823 Protein export membrane protein; Region: SecD_SecF; pfam02355 266264009824 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 266264009825 CoA-transferase family III; Region: CoA_transf_3; pfam02515 266264009826 Response regulator receiver domain; Region: Response_reg; pfam00072 266264009827 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266264009828 active site 266264009829 phosphorylation site [posttranslational modification] 266264009830 intermolecular recognition site; other site 266264009831 dimerization interface [polypeptide binding]; other site 266264009832 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266264009833 active site 266264009834 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 266264009835 phosphorylation site [posttranslational modification] 266264009836 intermolecular recognition site; other site 266264009837 dimerization interface [polypeptide binding]; other site 266264009838 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 266264009839 dimer interface [polypeptide binding]; other site 266264009840 phosphorylation site [posttranslational modification] 266264009841 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266264009842 ATP binding site [chemical binding]; other site 266264009843 Mg2+ binding site [ion binding]; other site 266264009844 G-X-G motif; other site 266264009845 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 266264009846 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 266264009847 dimer interface [polypeptide binding]; other site 266264009848 phosphorylation site [posttranslational modification] 266264009849 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266264009850 ATP binding site [chemical binding]; other site 266264009851 Mg2+ binding site [ion binding]; other site 266264009852 G-X-G motif; other site 266264009853 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 266264009854 S-adenosylmethionine binding site [chemical binding]; other site 266264009855 Uncharacterized conserved protein [Function unknown]; Region: COG2353 266264009856 YceI-like domain; Region: YceI; smart00867 266264009857 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 266264009858 adenylosuccinate lyase; Provisional; Region: PRK09285 266264009859 PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598 266264009860 tetramer interface [polypeptide binding]; other site 266264009861 active site 266264009862 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase 266264009863 putative glutathione S-transferase; Provisional; Region: PRK10357 266264009864 GST_N family, unknown subfamily 3; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_3; cd03049 266264009865 putative C-terminal domain interface [polypeptide binding]; other site 266264009866 putative GSH binding site (G-site) [chemical binding]; other site 266264009867 putative dimer interface [polypeptide binding]; other site 266264009868 C-terminal, alpha helical domain of an unknown subfamily 6 of Glutathione S-transferases; Region: GST_C_6; cd03205 266264009869 dimer interface [polypeptide binding]; other site 266264009870 N-terminal domain interface [polypeptide binding]; other site 266264009871 putative substrate binding pocket (H-site) [chemical binding]; other site 266264009872 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 266264009873 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 266264009874 Contains a crystal structure of the Nudix hydrolase from Nitrosomonas europaea, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_2; cd03675 266264009875 nudix motif; other site 266264009876 Dihydrodipicolinate synthase (Fragment) 266264009877 Bacterial protein of unknown function (Gcw_chp); Region: Gcw_chp; pfam09694 266264009878 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 266264009879 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 266264009880 ligand binding site [chemical binding]; other site 266264009881 homodimer interface [polypeptide binding]; other site 266264009882 NAD(P) binding site [chemical binding]; other site 266264009883 trimer interface B [polypeptide binding]; other site 266264009884 trimer interface A [polypeptide binding]; other site 266264009885 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 266264009886 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282 266264009887 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 266264009888 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266264009889 active site 266264009890 phosphorylation site [posttranslational modification] 266264009891 intermolecular recognition site; other site 266264009892 dimerization interface [polypeptide binding]; other site 266264009893 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 266264009894 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 266264009895 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 266264009896 2-hydroxychromene-2-carboxylate isomerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NahD; COG3917 266264009897 DsbA family, 2-hydroxychromene-2-carboxylate (HCCA) isomerase subfamily; HCCA isomerase is a glutathione (GSH) dependent enzyme involved in the naphthalene catabolic pathway. It converts HCCA, a hemiketal formed spontaneously after ring cleavage of 1; Region: DsbA_HCCA_Iso; cd03022 266264009898 putative catalytic residue [active] 266264009899 Predicted membrane protein [Function unknown]; Region: COG1981 266264009900 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 266264009901 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 266264009902 putative catalytic cysteine [active] 266264009903 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 266264009904 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 266264009905 Lipopolysaccharide-assembly; Region: LptE; cl01125 266264009906 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 266264009907 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 266264009908 HIGH motif; other site 266264009909 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 266264009910 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 266264009911 active site 266264009912 KMSKS motif; other site 266264009913 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 266264009914 tRNA binding surface [nucleotide binding]; other site 266264009915 dihydrodipicolinate reductase; Provisional; Region: PRK00048 266264009916 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 266264009917 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 266264009918 Outer membrane lipoprotein OmlA (small protein A) [Cell envelope biogenesis, outer membrane]; Region: OlmA; COG2913 266264009919 SmpA / OmlA family; Region: SmpA_OmlA; pfam04355 266264009920 ferric uptake regulator; Provisional; Region: fur; PRK09462 266264009921 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 266264009922 metal binding site 2 [ion binding]; metal-binding site 266264009923 putative DNA binding helix; other site 266264009924 metal binding site 1 [ion binding]; metal-binding site 266264009925 dimer interface [polypeptide binding]; other site 266264009926 structural Zn2+ binding site [ion binding]; other site 266264009927 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266264009928 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266264009929 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 266264009930 dimerization interface [polypeptide binding]; other site 266264009931 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 266264009932 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 266264009933 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 266264009934 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 266264009935 transketolase; Reviewed; Region: PRK12753 266264009936 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 266264009937 TPP-binding site [chemical binding]; other site 266264009938 dimer interface [polypeptide binding]; other site 266264009939 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 266264009940 PYR/PP interface [polypeptide binding]; other site 266264009941 dimer interface [polypeptide binding]; other site 266264009942 TPP binding site [chemical binding]; other site 266264009943 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 266264009944 spermidine synthase; Provisional; Region: PRK00811 266264009945 Spermidine synthase [Amino acid transport and metabolism]; Region: SpeE; COG0421 266264009946 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246 266264009947 putative dimer interface [polypeptide binding]; other site 266264009948 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 266264009949 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 266264009950 RNA methyltransferase, RsmE family; Region: TIGR00046 266264009951 Bacterial protein of unknown function (DUF937); Region: DUF937; cl01528 266264009952 Barstar_evA4336-like contains uncharacterized sequences similar to the uncharacterized, predicted RNAase inhibitor evA4336 found in Azoarcus sp. EvN1. This is a subfamily of the Barstar family of RNAase inhibitors. Barstar is an intracellular inhibitor...; Region: Barstar_evA4336-like; cd05141 266264009953 putative RNAase interaction site [polypeptide binding]; other site 266264009954 RNase_Sa. Ribonucleases first isolated from Streptomyces aureofaciens. In general, ribonucleases cleave phosphodiester bonds in RNA and are essential for both non-specific RNA degradation and for numerous forms of RNA processing. RNAse Sa is a guanylate...; Region: RNase_Sa; cd00607 266264009955 active site 266264009956 barstar interaction site; other site 266264009957 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cl00246 266264009958 FAD binding site [chemical binding]; other site 266264009959 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1636 266264009960 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 266264009961 Helix-turn-helix domain; Region: HTH_28; pfam13518 266264009962 putative transposase OrfB; Reviewed; Region: PHA02517 266264009963 HTH-like domain; Region: HTH_21; pfam13276 266264009964 Integrase core domain; Region: rve; pfam00665 266264009965 Integrase core domain; Region: rve_2; pfam13333 266264009966 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 266264009967 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 266264009968 NAD binding site [chemical binding]; other site 266264009969 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 266264009970 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266264009971 dimer interface [polypeptide binding]; other site 266264009972 conserved gate region; other site 266264009973 ABC-ATPase subunit interface; other site 266264009974 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 266264009975 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 266264009976 ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638 266264009977 ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256 266264009978 Walker A/P-loop; other site 266264009979 ATP binding site [chemical binding]; other site 266264009980 Q-loop/lid; other site 266264009981 ABC transporter signature motif; other site 266264009982 Walker B; other site 266264009983 D-loop; other site 266264009984 H-loop/switch region; other site 266264009985 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266264009986 aminoethylphosphonate catabolism associated LysR family transcriptional regulator; Region: phn_lysR; TIGR03339 266264009987 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 266264009988 dimerization interface [polypeptide binding]; other site 266264009989 LysE type translocator; Region: LysE; cl00565 266264009990 transposase (fragment) Tn3 family 266264009991 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 266264009992 PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as bacitracin transport permeases, as it was suspected that they form the permease component of an ABC transporter system. It was shown, however, that BcrC from...; Region: PAP2_BcrC_like; cd03385 266264009993 active site 266264009994 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 266264009995 Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4705 266264009996 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 266264009997 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 266264009998 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 266264009999 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 266264010000 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 266264010001 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 266264010002 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 266264010003 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 266264010004 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266264010005 active site 266264010006 phosphorylation site [posttranslational modification] 266264010007 intermolecular recognition site; other site 266264010008 dimerization interface [polypeptide binding]; other site 266264010009 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 266264010010 DNA binding site [nucleotide binding] 266264010011 sensor protein QseC; Provisional; Region: PRK10337 266264010012 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 266264010013 dimer interface [polypeptide binding]; other site 266264010014 phosphorylation site [posttranslational modification] 266264010015 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266264010016 ATP binding site [chemical binding]; other site 266264010017 Mg2+ binding site [ion binding]; other site 266264010018 G-X-G motif; other site 266264010019 Predicted membrane protein [Function unknown]; Region: COG2510 266264010020 multiple promoter invertase; Provisional; Region: mpi; PRK13413 266264010021 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 266264010022 catalytic residues [active] 266264010023 catalytic nucleophile [active] 266264010024 Presynaptic Site I dimer interface [polypeptide binding]; other site 266264010025 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 266264010026 Synaptic Flat tetramer interface [polypeptide binding]; other site 266264010027 Synaptic Site I dimer interface [polypeptide binding]; other site 266264010028 DNA binding site [nucleotide binding] 266264010029 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 266264010030 DNA-binding interface [nucleotide binding]; DNA binding site 266264010031 TniQ; Region: TniQ; pfam06527 266264010032 Bacterial TniB protein; Region: TniB; pfam05621 266264010033 Integrase core domain; Region: rve; pfam00665 266264010034 Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299 266264010035 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 266264010036 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 266264010037 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 266264010038 HlyD family secretion protein; Region: HlyD_3; pfam13437 266264010039 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 266264010040 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_1; cd02432 266264010041 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 266264010042 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 266264010043 dimer interface [polypeptide binding]; other site 266264010044 phosphorylation site [posttranslational modification] 266264010045 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266264010046 Mg2+ binding site [ion binding]; other site 266264010047 G-X-G motif; other site 266264010048 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 266264010049 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266264010050 active site 266264010051 phosphorylation site [posttranslational modification] 266264010052 intermolecular recognition site; other site 266264010053 dimerization interface [polypeptide binding]; other site 266264010054 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 266264010055 DNA binding site [nucleotide binding] 266264010056 Predicted ferric reductase [Inorganic ion transport and metabolism]; Region: COG4097 266264010057 Ferric reductase like transmembrane component; Region: Ferric_reduct; pfam01794 266264010058 NAD(P) binding domain of ferredoxin reductase-like proteins catalyze electron transfer between an NAD(P)-binding sub-domain of the alpha/beta class and a discrete (usually N-terminal) domain, which varies in orientation with respect to the NAD(P)...; Region: FNR_like_3; cd06198 266264010059 FAD binding pocket [chemical binding]; other site 266264010060 FAD binding motif [chemical binding]; other site 266264010061 phosphate binding motif [ion binding]; other site 266264010062 beta-alpha-beta structure motif; other site 266264010063 NAD binding pocket [chemical binding]; other site 266264010064 Type IV secretory pathway, VirD2 components (relaxase) [Intracellular trafficking and secretion]; Region: VirD2; COG3843 266264010065 Protein of unknown function (DUF3363); Region: DUF3363; pfam11843 266264010066 conjugal transfer pilin processing protease TraF; Provisional; Region: PRK13838 266264010067 Signal peptidase, peptidase S26; Region: Peptidase_S26; pfam10502 266264010068 Protein of unknown function (DUF2840); Region: DUF2840; pfam11000 266264010069 ParA-like protein; Provisional; Region: PHA02518 266264010070 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 266264010071 P-loop; other site 266264010072 Magnesium ion binding site [ion binding]; other site 266264010073 Replication initiator protein A; Region: RPA; pfam10134 266264010074 Helix-turn-helix domain; Region: HTH_17; cl17695 266264010075 Uncharacterized conserved protein (DUF2285); Region: DUF2285; pfam10074 266264010076 Protein of unknown function (DUF2958); Region: DUF2958; pfam11171 266264010077 hypothetical protein 266264010078 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 266264010079 non-specific DNA binding site [nucleotide binding]; other site 266264010080 salt bridge; other site 266264010081 sequence-specific DNA binding site [nucleotide binding]; other site 266264010082 Uncharacterized conserved protein [Function unknown]; Region: COG5489 266264010083 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 266264010084 Coenzyme A binding pocket [chemical binding]; other site 266264010085 ParB-like nuclease domain; Region: ParB; smart00470 266264010086 Domain of unknown function (DUF932); Region: DUF932; pfam06067 266264010087 conserved hypothetical protein 266264010088 putative chaperone protein EcpD; Provisional; Region: PRK09926 266264010089 Protein of unknown function (DUF2958); Region: DUF2958; pfam11171 266264010090 Predicted hydrolase (metallo-beta-lactamase superfamily) 266264010091 Prokaryotic E2 family A; Region: Prok-E2_A; pfam14457 266264010092 Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cl17196 266264010093 ATP binding site [chemical binding]; other site 266264010094 Prokaryotic homologs of the JAB domain; Region: Prok-JAB; pfam14464 266264010095 WYL domain; Region: WYL; pfam13280 266264010096 Protein of unknown function (DUF1016); Region: DUF1016; pfam06250 266264010097 Predicted nuclease of restriction endonuclease-like fold [General function prediction only]; Region: COG4804 266264010098 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 266264010099 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 266264010100 active site 266264010101 Int/Topo IB signature motif; other site 266264010102 DNA binding site [nucleotide binding] 266264010103 Malate dehydrogenase enzyme; Region: Malate_DH; pfam12434 266264010104 malic enzyme; Reviewed; Region: PRK12862 266264010105 Malic enzyme, N-terminal domain; Region: malic; pfam00390 266264010106 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 266264010107 putative NAD(P) binding site [chemical binding]; other site 266264010108 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 266264010109 thiamine monophosphate kinase; Provisional; Region: PRK05731 266264010110 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 266264010111 ATP binding site [chemical binding]; other site 266264010112 dimerization interface [polypeptide binding]; other site 266264010113 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 266264010114 tetramer interfaces [polypeptide binding]; other site 266264010115 binuclear metal-binding site [ion binding]; other site 266264010116 Uncharacterized protein (competence- and mitomycin-induced) [General function prediction only]; Region: CinA; COG1546 266264010117 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 266264010118 active site 266264010119 dimer interface [polypeptide binding]; other site 266264010120 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 266264010121 EamA-like transporter family; Region: EamA; pfam00892 266264010122 EamA-like transporter family; Region: EamA; pfam00892 266264010123 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 266264010124 Escherichia coli Mg2+ transporter CorA_like subgroup; Region: EcCorA-like_1; cd12835 266264010125 Cl binding site [ion binding]; other site 266264010126 oligomer interface [polypeptide binding]; other site 266264010127 monofunctional biosynthetic peptidoglycan transglycosylase; Provisional; Region: mtgA; PRK00056 266264010128 Transglycosylase; Region: Transgly; cl17702 266264010129 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 266264010130 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 266264010131 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 266264010132 shikimate binding site; other site 266264010133 NAD(P) binding site [chemical binding]; other site 266264010134 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 266264010135 TonB family C-terminal domain; Region: tonB_Cterm; TIGR01352 266264010136 This domain is the catalytic domain of ribonuclease II; Region: RNB; smart00955 266264010137 RNB domain; Region: RNB; pfam00773 266264010138 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 266264010139 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266264010140 NAD(P) binding site [chemical binding]; other site 266264010141 active site 266264010142 Chorismate lyase; Region: Chor_lyase; cl01230 266264010143 Uncharacterized protein family (UPF0227); Region: UPF0227; cl14886 266264010144 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 266264010145 UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Region: mpl; TIGR01081 266264010146 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 266264010147 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 266264010148 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 266264010149 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 266264010150 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 266264010151 catalytic residues [active] 266264010152 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 266264010153 Dehydroquinase class II; Region: DHquinase_II; pfam01220 266264010154 trimer interface [polypeptide binding]; other site 266264010155 active site 266264010156 dimer interface [polypeptide binding]; other site 266264010157 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 266264010158 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 266264010159 carboxyltransferase (CT) interaction site; other site 266264010160 biotinylation site [posttranslational modification]; other site 266264010161 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 266264010162 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 266264010163 ATP-grasp domain; Region: ATP-grasp_4; cl17255 266264010164 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 266264010165 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 266264010166 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 266264010167 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 266264010168 S-adenosylmethionine binding site [chemical binding]; other site 266264010169 MJ0042 family finger-like domain; Region: MJ0042_CXXC; TIGR02098 266264010170 Protein of unknown function (DUF3426); Region: DUF3426; pfam11906 266264010171 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 266264010172 dimer interface [polypeptide binding]; other site 266264010173 catalytic triad [active] 266264010174 peroxidatic and resolving cysteines [active] 266264010175 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 266264010176 Ribokinase-like subgroup A. Found in bacteria and archaea, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_A; cd01942 266264010177 substrate binding site [chemical binding]; other site 266264010178 ATP binding site [chemical binding]; other site 266264010179 Glycine zipper 2TM domain; Region: Rick_17kDa_Anti; cl10470 266264010180 isoleucyl-tRNA synthetase; Region: ileS; TIGR00392 266264010181 Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; pfam09917 266264010182 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 266264010183 Outer membrane receptor for monomeric catechols [Inorganic ion transport and metabolism]; Region: Fiu; COG4774 266264010184 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 266264010185 N-terminal plug; other site 266264010186 ligand-binding site [chemical binding]; other site 266264010187 Fe(II)-dependent oxygenase superfamily protein; Provisional; Region: PRK05467 266264010188 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266264010189 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266264010190 LysR substrate binding domain; Region: LysR_substrate; pfam03466 266264010191 dimerization interface [polypeptide binding]; other site 266264010192 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 266264010193 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 266264010194 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 266264010195 active site 266264010196 catalytic tetrad [active] 266264010197 The SYLF domain (also called DUF500), a novel lipid-binding module; Region: SYLF; cd11524 266264010198 putative amphipathic alpha helix; other site 266264010199 recombination associated protein; Reviewed; Region: rdgC; PRK00321 266264010200 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 266264010201 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 266264010202 putative NAD(P) binding site [chemical binding]; other site 266264010203 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 266264010204 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 266264010205 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 266264010206 dimer interface [polypeptide binding]; other site 266264010207 putative radical transfer pathway; other site 266264010208 diiron center [ion binding]; other site 266264010209 tyrosyl radical; other site 266264010210 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07207 266264010211 ATP cone domain; Region: ATP-cone; pfam03477 266264010212 Class I ribonucleotide reductase; Region: RNR_I; cd01679 266264010213 active site 266264010214 dimer interface [polypeptide binding]; other site 266264010215 catalytic residues [active] 266264010216 effector binding site; other site 266264010217 R2 peptide binding site; other site 266264010218 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 266264010219 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 266264010220 amidase catalytic site [active] 266264010221 Zn binding residues [ion binding]; other site 266264010222 substrate binding site [chemical binding]; other site 266264010223 Response regulator receiver domain; Region: Response_reg; pfam00072 266264010224 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266264010225 active site 266264010226 phosphorylation site [posttranslational modification] 266264010227 intermolecular recognition site; other site 266264010228 dimerization interface [polypeptide binding]; other site 266264010229 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 266264010230 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 266264010231 Walker A motif; other site 266264010232 ATP binding site [chemical binding]; other site 266264010233 Walker B motif; other site 266264010234 arginine finger; other site 266264010235 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 266264010236 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 266264010237 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 266264010238 dimer interface [polypeptide binding]; other site 266264010239 phosphorylation site [posttranslational modification] 266264010240 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266264010241 ATP binding site [chemical binding]; other site 266264010242 Mg2+ binding site [ion binding]; other site 266264010243 G-X-G motif; other site 266264010244 FHIPEP family; Region: FHIPEP; pfam00771 266264010245 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 266264010246 signal recognition particle protein; Provisional; Region: PRK10867 266264010247 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 266264010248 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 266264010249 P loop; other site 266264010250 GTP binding site [chemical binding]; other site 266264010251 Signal peptide binding domain; Region: SRP_SPB; pfam02978 266264010252 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 266264010253 active site 266264010254 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 266264010255 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 266264010256 active site 266264010257 Prolyl 4-hydroxylase alpha subunit homologues; Region: P4Hc; smart00702 266264010258 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 266264010259 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 266264010260 N-acetyl-D-glucosamine binding site [chemical binding]; other site 266264010261 catalytic residue [active] 266264010262 prolyl-tRNA synthetase; Provisional; Region: PRK09194 266264010263 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 266264010264 dimer interface [polypeptide binding]; other site 266264010265 motif 1; other site 266264010266 active site 266264010267 motif 2; other site 266264010268 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 266264010269 putative deacylase active site [active] 266264010270 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 266264010271 active site 266264010272 motif 3; other site 266264010273 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 266264010274 anticodon binding site; other site 266264010275 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671 266264010276 putative active site [active] 266264010277 Ap4A binding site [chemical binding]; other site 266264010278 nudix motif; other site 266264010279 putative metal binding site [ion binding]; other site 266264010280 CNP1-like family; Region: CNP1; pfam08750 266264010281 gamma-glutamyl kinase; Provisional; Region: PRK05429 266264010282 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 266264010283 nucleotide binding site [chemical binding]; other site 266264010284 homotetrameric interface [polypeptide binding]; other site 266264010285 putative phosphate binding site [ion binding]; other site 266264010286 putative allosteric binding site; other site 266264010287 PUA domain; Region: PUA; pfam01472 266264010288 GTPase CgtA; Reviewed; Region: obgE; PRK12299 266264010289 GTP1/OBG; Region: GTP1_OBG; pfam01018 266264010290 Obg GTPase; Region: Obg; cd01898 266264010291 G1 box; other site 266264010292 GTP/Mg2+ binding site [chemical binding]; other site 266264010293 Switch I region; other site 266264010294 G2 box; other site 266264010295 G3 box; other site 266264010296 Switch II region; other site 266264010297 G4 box; other site 266264010298 G5 box; other site 266264010299 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 266264010300 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 266264010301 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 266264010302 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 266264010303 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 266264010304 substrate binding pocket [chemical binding]; other site 266264010305 chain length determination region; other site 266264010306 substrate-Mg2+ binding site; other site 266264010307 catalytic residues [active] 266264010308 aspartate-rich region 1; other site 266264010309 active site lid residues [active] 266264010310 aspartate-rich region 2; other site 266264010311 type IV-A pilus assembly ATPase PilB; Region: type_IV_pilB; TIGR02538 266264010312 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 266264010313 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 266264010314 Walker A motif; other site 266264010315 ATP binding site [chemical binding]; other site 266264010316 Walker B motif; other site 266264010317 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 266264010318 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 266264010319 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 266264010320 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 266264010321 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 266264010322 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 266264010323 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 266264010324 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 266264010325 CoA-binding site [chemical binding]; other site 266264010326 ATP-binding [chemical binding]; other site 266264010327 hypothetical protein; Provisional; Region: PRK05287 266264010328 Domain of unknown function (DUF329); Region: DUF329; pfam03884 266264010329 Predicted membrane protein [Function unknown]; Region: COG1297 266264010330 putative oligopeptide transporter, OPT family; Region: TIGR00733 266264010331 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 266264010332 active site 266264010333 8-oxo-dGMP binding site [chemical binding]; other site 266264010334 nudix motif; other site 266264010335 metal binding site [ion binding]; metal-binding site 266264010336 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG2607 266264010337 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 266264010338 Walker A motif; other site 266264010339 ATP binding site [chemical binding]; other site 266264010340 Walker B motif; other site 266264010341 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 266264010342 heterotetramer interface [polypeptide binding]; other site 266264010343 active site pocket [active] 266264010344 cleavage site 266264010345 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 266264010346 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 266264010347 SEC-C motif; Region: SEC-C; pfam02810 266264010348 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 266264010349 Peptidase family M23; Region: Peptidase_M23; pfam01551 266264010350 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 266264010351 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 266264010352 Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013 266264010353 catalytic triad [active] 266264010354 dimer interface [polypeptide binding]; other site 266264010355 cell division protein FtsZ; Validated; Region: PRK09330 266264010356 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 266264010357 nucleotide binding site [chemical binding]; other site 266264010358 SulA interaction site; other site 266264010359 cell division protein FtsA; Region: ftsA; TIGR01174 266264010360 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 266264010361 nucleotide binding site [chemical binding]; other site 266264010362 Cell division protein FtsA; Region: FtsA; pfam14450 266264010363 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 266264010364 Cell division protein FtsQ; Region: FtsQ; pfam03799 266264010365 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 266264010366 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 266264010367 ATP-grasp domain; Region: ATP-grasp_4; cl17255 266264010368 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 266264010369 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 266264010370 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 266264010371 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 266264010372 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 266264010373 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 266264010374 active site 266264010375 homodimer interface [polypeptide binding]; other site 266264010376 cell division protein FtsW; Region: ftsW; TIGR02614 266264010377 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02006 266264010378 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 266264010379 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 266264010380 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 266264010381 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 266264010382 Mg++ binding site [ion binding]; other site 266264010383 putative catalytic motif [active] 266264010384 putative substrate binding site [chemical binding]; other site 266264010385 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 266264010386 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 266264010387 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 266264010388 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 266264010389 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 266264010390 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 266264010391 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 266264010392 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 266264010393 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 266264010394 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 266264010395 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 266264010396 cell division protein FtsL; Region: ftsL_broad; TIGR02209 266264010397 MraW methylase family; Region: Methyltransf_5; cl17771 266264010398 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 266264010399 MraZ protein; Region: MraZ; pfam02381 266264010400 cell division protein MraZ; Reviewed; Region: PRK00326 266264010401 MraZ protein; Region: MraZ; pfam02381 266264010402 Demethoxyubiquinone hydroxylase, ferritin-like diiron-binding domain; Region: DMQH; cd01042 266264010403 diiron binding motif [ion binding]; other site 266264010404 outer membrane protein (porin) (fragment) 266264010405 AAA domain; Region: AAA_22; pfam13401 266264010406 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 266264010407 Walker A motif; other site 266264010408 ATP binding site [chemical binding]; other site 266264010409 Walker B motif; other site 266264010410 arginine finger; other site 266264010411 Integrase core domain; Region: rve; pfam00665 266264010412 outer membrane protein (porin) 266264010413 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 266264010414 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 266264010415 MarR family; Region: MarR; pfam01047 266264010416 Long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07059 266264010417 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 266264010418 acyl-activating enzyme (AAE) consensus motif; other site 266264010419 putative AMP binding site [chemical binding]; other site 266264010420 putative active site [active] 266264010421 putative CoA binding site [chemical binding]; other site 266264010422 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 266264010423 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 266264010424 Predicted aminopeptidase (DUF2265); Region: DUF2265; pfam10023 266264010425 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 266264010426 The MopB_3 CD includes a group of related uncharacterized bacterial and archaeal molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members...; Region: MopB_3; cd02766 266264010427 putative [4Fe-4S] binding site [ion binding]; other site 266264010428 putative molybdopterin cofactor binding site [chemical binding]; other site 266264010429 The MopB_CT_3 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is of the...; Region: MopB_CT_3; cd02786 266264010430 putative molybdopterin cofactor binding site; other site 266264010431 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 266264010432 Type I periplasmic binding domain of uncharacterized extracellular ligand-binding proteins; Region: PBP1_STKc_like; cd06326 266264010433 putative ligand binding site [chemical binding]; other site 266264010434 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 266264010435 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 266264010436 Walker A/P-loop; other site 266264010437 ATP binding site [chemical binding]; other site 266264010438 Q-loop/lid; other site 266264010439 ABC transporter signature motif; other site 266264010440 Walker B; other site 266264010441 D-loop; other site 266264010442 H-loop/switch region; other site 266264010443 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 266264010444 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 266264010445 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 266264010446 Walker A/P-loop; other site 266264010447 ATP binding site [chemical binding]; other site 266264010448 Q-loop/lid; other site 266264010449 ABC transporter signature motif; other site 266264010450 Walker B; other site 266264010451 D-loop; other site 266264010452 H-loop/switch region; other site 266264010453 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 266264010454 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 266264010455 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266264010456 putative PBP binding loops; other site 266264010457 ABC-ATPase subunit interface; other site 266264010458 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 266264010459 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266264010460 dimer interface [polypeptide binding]; other site 266264010461 conserved gate region; other site 266264010462 putative PBP binding loops; other site 266264010463 ABC-ATPase subunit interface; other site 266264010464 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 266264010465 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_2; cd08498 266264010466 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 266264010467 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 266264010468 metal binding site [ion binding]; metal-binding site 266264010469 putative dimer interface [polypeptide binding]; other site 266264010470 Protein of unknown function (DUF2891); Region: DUF2891; pfam11199 266264010471 Protein of unknown function (DUF3047); Region: DUF3047; pfam11249 266264010472 hypothetical protein 266264010473 enoyl-CoA hydratase; Provisional; Region: PRK05862 266264010474 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 266264010475 substrate binding site [chemical binding]; other site 266264010476 oxyanion hole (OAH) forming residues; other site 266264010477 trimer interface [polypeptide binding]; other site 266264010478 enoyl-CoA hydratase; Provisional; Region: PRK08140 266264010479 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 266264010480 substrate binding site [chemical binding]; other site 266264010481 oxyanion hole (OAH) forming residues; other site 266264010482 trimer interface [polypeptide binding]; other site 266264010483 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 266264010484 CoenzymeA binding site [chemical binding]; other site 266264010485 subunit interaction site [polypeptide binding]; other site 266264010486 PHB binding site; other site 266264010487 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 266264010488 phenylacetate-CoA ligase; Region: PA_CoA_ligase; TIGR02155 266264010489 acyl-activating enzyme (AAE) consensus motif; other site 266264010490 AMP binding site [chemical binding]; other site 266264010491 active site 266264010492 CoA binding site [chemical binding]; other site 266264010493 anaerobic nitric oxide reductase transcription regulator; Provisional; Region: PRK05022 266264010494 GAF domain; Region: GAF; pfam01590 266264010495 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 266264010496 Walker A motif; other site 266264010497 ATP binding site [chemical binding]; other site 266264010498 Walker B motif; other site 266264010499 arginine finger; other site 266264010500 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 266264010501 Nitric oxide reductase large subunit [Inorganic ion transport and metabolism]; Region: NorB; COG3256 266264010502 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 266264010503 active site 266264010504 SAM binding site [chemical binding]; other site 266264010505 homodimer interface [polypeptide binding]; other site 266264010506 Cytochrome c; Region: Cytochrom_C; cl11414 266264010507 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 266264010508 Cytochrome D1 heme domain; Region: Cytochrom_D1; pfam02239 266264010509 heme d1 biosynthesis radical SAM protein NirJ; Region: rSAM_NirJ; TIGR04051 266264010510 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 266264010511 FeS/SAM binding site; other site 266264010512 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 266264010513 Cytochrome c; Region: Cytochrom_C; cl11414 266264010514 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 266264010515 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 266264010516 Cytochrome D1 heme domain; Region: Cytochrom_D1; pfam02239 266264010517 MltA specific insert domain; Region: MltA; smart00925 266264010518 3D domain; Region: 3D; pfam06725 266264010519 CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461 266264010520 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 266264010521 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 266264010522 substrate binding site [chemical binding]; other site 266264010523 hexamer interface [polypeptide binding]; other site 266264010524 metal binding site [ion binding]; metal-binding site 266264010525 2-phosphoglycolate phosphatase, prokaryotic; Region: PGP_bact; TIGR01449 266264010526 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 266264010527 motif II; other site 266264010528 anthranilate synthase component I; Provisional; Region: PRK13565 266264010529 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 266264010530 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 266264010531 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 266264010532 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 266264010533 glutamine binding [chemical binding]; other site 266264010534 catalytic triad [active] 266264010535 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 266264010536 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 266264010537 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 266264010538 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 266264010539 active site 266264010540 ribulose/triose binding site [chemical binding]; other site 266264010541 phosphate binding site [ion binding]; other site 266264010542 substrate (anthranilate) binding pocket [chemical binding]; other site 266264010543 product (indole) binding pocket [chemical binding]; other site 266264010544 Uncharacterized subgroup of the CYTH-like superfamily having an associated CHAD domain; Region: CYTH-like_Pase_CHAD; cd07756 266264010545 putative active site [active] 266264010546 putative triphosphate binding site [ion binding]; other site 266264010547 putative metal binding residues [ion binding]; other site 266264010548 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 266264010549 ligand binding site [chemical binding]; other site 266264010550 active site 266264010551 UGI interface [polypeptide binding]; other site 266264010552 catalytic site [active] 266264010553 acylphosphatase; Provisional; Region: PRK14430 266264010554 ABC-type anion transport system, duplicated permease component [Inorganic ion transport and metabolism]; Region: COG4986 266264010555 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266264010556 dimer interface [polypeptide binding]; other site 266264010557 conserved gate region; other site 266264010558 putative PBP binding loops; other site 266264010559 ABC-ATPase subunit interface; other site 266264010560 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266264010561 dimer interface [polypeptide binding]; other site 266264010562 conserved gate region; other site 266264010563 putative PBP binding loops; other site 266264010564 ABC-ATPase subunit interface; other site 266264010565 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 266264010566 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 266264010567 Walker A/P-loop; other site 266264010568 ATP binding site [chemical binding]; other site 266264010569 Q-loop/lid; other site 266264010570 ABC transporter signature motif; other site 266264010571 Walker B; other site 266264010572 D-loop; other site 266264010573 H-loop/switch region; other site 266264010574 ABC nitrate/sulfonate/bicarbonate family transporter, ATPase subunit; Region: ABC_transp; cl15413 266264010575 integral membrane protein, YccS/YhfK family; Region: YCCS_YHJK; TIGR01667 266264010576 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 266264010577 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 266264010578 Predicted protease with the C-terminal PDZ domain [General function prediction only]; Region: COG3975 266264010579 M61 glycyl aminopeptidase; Region: Peptidase_M61; pfam05299 266264010580 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 266264010581 protein binding site [polypeptide binding]; other site 266264010582 Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288 266264010583 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 266264010584 NADP binding site [chemical binding]; other site 266264010585 dimer interface [polypeptide binding]; other site 266264010586 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 266264010587 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 266264010588 dimerization domain [polypeptide binding]; other site 266264010589 dimer interface [polypeptide binding]; other site 266264010590 catalytic residues [active] 266264010591 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608 266264010592 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 266264010593 Putative membrane protein (fragment) PAP2 family protein 266264010594 GTP-binding protein YchF; Reviewed; Region: PRK09601 266264010595 YchF GTPase; Region: YchF; cd01900 266264010596 G1 box; other site 266264010597 GTP/Mg2+ binding site [chemical binding]; other site 266264010598 Switch I region; other site 266264010599 G2 box; other site 266264010600 Switch II region; other site 266264010601 G3 box; other site 266264010602 G4 box; other site 266264010603 G5 box; other site 266264010604 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 266264010605 GDYXXLXY protein; Region: GDYXXLXY; pfam14345 266264010606 Domain of unknown function (DUF4401); Region: DUF4401; pfam14351 266264010607 Predicted membrane protein (DUF2157); Region: DUF2157; pfam09925 266264010608 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 266264010609 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 266264010610 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 266264010611 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 266264010612 tRNA; other site 266264010613 putative tRNA binding site [nucleotide binding]; other site 266264010614 putative NADP binding site [chemical binding]; other site 266264010615 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 266264010616 peptide chain release factor 1; Validated; Region: prfA; PRK00591 266264010617 This domain is found in peptide chain release factors; Region: PCRF; smart00937 266264010618 RF-1 domain; Region: RF-1; pfam00472 266264010619 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 266264010620 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 266264010621 S-adenosylmethionine binding site [chemical binding]; other site 266264010622 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 266264010623 putative GSH binding site [chemical binding]; other site 266264010624 catalytic residues [active] 266264010625 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Provisional; Region: PRK06029 266264010626 Flavoprotein; Region: Flavoprotein; pfam02441 266264010627 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 266264010628 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 266264010629 NAD(P) binding site [chemical binding]; other site 266264010630 catalytic residues [active] 266264010631 Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748 266264010632 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266264010633 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 266264010634 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 266264010635 AsnC family; Region: AsnC_trans_reg; pfam01037 266264010636 dihydrodipicolinate reductase; Provisional; Region: PRK00048 266264010637 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 266264010638 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 266264010639 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 266264010640 ClC chloride channel family. These protein sequences, closely related to the ClC Eric family, are putative halogen ion (Cl-, Br- and I-) transport proteins found in eubacteria. They belong to the ClC superfamily of chloride ion channels, which share a...; Region: EriC_like; cd01034 266264010641 putative ion selectivity filter; other site 266264010642 putative pore gating glutamate residue; other site 266264010643 putative H+/Cl- coupling transport residue; other site 266264010644 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 266264010645 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08276 266264010646 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 266264010647 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 266264010648 acyl-activating enzyme (AAE) consensus motif; other site 266264010649 acyl-activating enzyme (AAE) consensus motif; other site 266264010650 putative AMP binding site [chemical binding]; other site 266264010651 putative active site [active] 266264010652 putative CoA binding site [chemical binding]; other site 266264010653 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266264010654 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266264010655 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 266264010656 putative effector binding pocket; other site 266264010657 dimerization interface [polypeptide binding]; other site 266264010658 Predicted transcriptional regulators [Transcription]; Region: COG1733 266264010659 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 266264010660 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 266264010661 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 266264010662 YXWGXW repeat (2 copies); Region: YXWGXW; pfam12779 266264010663 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 266264010664 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 266264010665 putative active site [active] 266264010666 putative metal binding site [ion binding]; other site 266264010667 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 266264010668 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 266264010669 Walker A/P-loop; other site 266264010670 ATP binding site [chemical binding]; other site 266264010671 Q-loop/lid; other site 266264010672 ABC transporter signature motif; other site 266264010673 Walker B; other site 266264010674 D-loop; other site 266264010675 H-loop/switch region; other site 266264010676 ABC transporter; Region: ABC_tran_2; pfam12848 266264010677 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 266264010678 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG1451 266264010679 TM1410 hypothetical-related protein; Region: DUF297; pfam03537 266264010680 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 266264010681 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 266264010682 metal binding site [ion binding]; metal-binding site 266264010683 active site 266264010684 I-site; other site 266264010685 ClpXP protease specificity-enhancing factor; Provisional; Region: PRK11798 266264010686 stringent starvation protein A; Provisional; Region: sspA; PRK09481 266264010687 GST_N family, Stringent starvation protein A (SspA) subfamily; SspA is a RNA polymerase (RNAP)-associated protein required for the lytic development of phage P1 and for stationary phase-induced acid tolerance of E. coli. It is implicated in survival...; Region: GST_N_SspA; cd03059 266264010688 C-terminal domain interface [polypeptide binding]; other site 266264010689 putative GSH binding site (G-site) [chemical binding]; other site 266264010690 dimer interface [polypeptide binding]; other site 266264010691 C-terminal, alpha helical domain of Stringent starvation protein A; Region: GST_C_SspA; cd03186 266264010692 dimer interface [polypeptide binding]; other site 266264010693 N-terminal domain interface [polypeptide binding]; other site 266264010694 Cytochrome C1 family; Region: Cytochrom_C1; pfam02167 266264010695 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 266264010696 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284 266264010697 Qi binding site; other site 266264010698 intrachain domain interface; other site 266264010699 interchain domain interface [polypeptide binding]; other site 266264010700 heme bH binding site [chemical binding]; other site 266264010701 heme bL binding site [chemical binding]; other site 266264010702 Qo binding site; other site 266264010703 Cytochrome b(C-terminal)/b6/petD; Region: Cytochrom_B_C; pfam00032 266264010704 ubiquinol-cytochrome c reductase, iron-sulfur subunit; Region: Rieske_proteo; TIGR01416 266264010705 Iron-sulfur protein (ISP) component of the bc(1) complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The bc(1) complex is a multisubunit enzyme found in many different organisms including...; Region: Rieske_cytochrome_bc1; cd03470 266264010706 [2Fe-2S] cluster binding site [ion binding]; other site 266264010707 large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13952 266264010708 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 266264010709 Uncharacterized conserved protein [Function unknown]; Region: COG0327 266264010710 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 266264010711 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 266264010712 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 266264010713 protein binding site [polypeptide binding]; other site 266264010714 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 266264010715 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 266264010716 trimer interface [polypeptide binding]; other site 266264010717 eyelet of channel; other site 266264010718 Sec-independent protein translocase protein (TatC); Region: TatC; cl00521 266264010719 sec-independent translocase; Provisional; Region: tatB; PRK01919 266264010720 twin arginine translocase protein A; Provisional; Region: tatA; PRK02958 266264010721 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 266264010722 nucleotide binding site/active site [active] 266264010723 HIT family signature motif; other site 266264010724 catalytic residue [active] 266264010725 Predicted membrane protein [Function unknown]; Region: COG3671 266264010726 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 266264010727 metal binding site [ion binding]; metal-binding site 266264010728 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 266264010729 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 266264010730 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 266264010731 substrate binding site [chemical binding]; other site 266264010732 glutamase interaction surface [polypeptide binding]; other site 266264010733 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 266264010734 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 266264010735 catalytic residues [active] 266264010736 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146 266264010737 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 266264010738 putative active site [active] 266264010739 oxyanion strand; other site 266264010740 catalytic triad [active] 266264010741 MarC family integral membrane protein; Region: MarC; cl00919 266264010742 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 266264010743 putative active site pocket [active] 266264010744 4-fold oligomerization interface [polypeptide binding]; other site 266264010745 metal binding residues [ion binding]; metal-binding site 266264010746 3-fold/trimer interface [polypeptide binding]; other site 266264010747 histidinol-phosphate aminotransferase; Provisional; Region: PRK04870 266264010748 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 266264010749 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266264010750 homodimer interface [polypeptide binding]; other site 266264010751 catalytic residue [active] 266264010752 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 266264010753 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 266264010754 NAD binding site [chemical binding]; other site 266264010755 dimerization interface [polypeptide binding]; other site 266264010756 product binding site; other site 266264010757 substrate binding site [chemical binding]; other site 266264010758 zinc binding site [ion binding]; other site 266264010759 catalytic residues [active] 266264010760 ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686 266264010761 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 266264010762 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 266264010763 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 266264010764 hinge; other site 266264010765 active site 266264010766 Predicted transcriptional regulator, BolA superfamily [Transcription]; Region: COG5007 266264010767 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 266264010768 ABC-2 type transporter; Region: ABC2_membrane; cl17235 266264010769 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 266264010770 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 266264010771 Walker A/P-loop; other site 266264010772 ATP binding site [chemical binding]; other site 266264010773 Q-loop/lid; other site 266264010774 ABC transporter signature motif; other site 266264010775 Walker B; other site 266264010776 D-loop; other site 266264010777 H-loop/switch region; other site 266264010778 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 266264010779 anti sigma factor interaction site; other site 266264010780 regulatory phosphorylation site [posttranslational modification]; other site 266264010781 Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; pfam05494 266264010782 VacJ like lipoprotein; Region: VacJ; cl01073 266264010783 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 266264010784 mce related protein; Region: MCE; pfam02470 266264010785 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 266264010786 Permease; Region: Permease; pfam02405 266264010787 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 266264010788 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 266264010789 Walker A/P-loop; other site 266264010790 ATP binding site [chemical binding]; other site 266264010791 Q-loop/lid; other site 266264010792 ABC transporter signature motif; other site 266264010793 Walker B; other site 266264010794 D-loop; other site 266264010795 H-loop/switch region; other site 266264010796 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 266264010797 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 266264010798 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 266264010799 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 266264010800 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 266264010801 active site 266264010802 dimer interface [polypeptide binding]; other site 266264010803 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 266264010804 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 266264010805 active site 266264010806 FMN binding site [chemical binding]; other site 266264010807 substrate binding site [chemical binding]; other site 266264010808 3Fe-4S cluster binding site [ion binding]; other site 266264010809 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 266264010810 domain interface; other site 266264010811 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG1943 266264010812 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01286 266264010813 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 266264010814 Zn2+ binding site [ion binding]; other site 266264010815 Mg2+ binding site [ion binding]; other site 266264010816 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 266264010817 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 266264010818 Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465 266264010819 active site 266264010820 dimer interface [polypeptide binding]; other site 266264010821 metal binding site [ion binding]; metal-binding site 266264010822 shikimate kinase; Reviewed; Region: aroK; PRK00131 266264010823 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 266264010824 ADP binding site [chemical binding]; other site 266264010825 magnesium binding site [ion binding]; other site 266264010826 putative shikimate binding site; other site 266264010827 AMIN domain; Region: AMIN; pfam11741 266264010828 type IV pilus secretin (or competence protein) PilQ; Region: IV_pilus_PilQ; TIGR02515 266264010829 Secretin and TonB N terminus short domain; Region: STN; smart00965 266264010830 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 266264010831 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 266264010832 Pilus assembly protein, PilP; Region: PilP; pfam04351 266264010833 Pilus assembly protein, PilO; Region: PilO; cl01234 266264010834 Tfp pilus assembly protein PilN [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilN; COG3166 266264010835 Fimbrial assembly protein (PilN); Region: PilN; pfam05137 266264010836 Cell division protein FtsA; Region: FtsA; cl17206 266264010837 Competence protein A; Region: Competence_A; pfam11104 266264010838 Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009 266264010839 Transglycosylase; Region: Transgly; pfam00912 266264010840 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 266264010841 frataxin-like protein; Provisional; Region: cyaY; PRK00446 266264010842 putative iron binding site [ion binding]; other site 266264010843 diaminopimelate decarboxylase; Region: lysA; TIGR01048 266264010844 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 266264010845 active site 266264010846 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 266264010847 substrate binding site [chemical binding]; other site 266264010848 catalytic residues [active] 266264010849 dimer interface [polypeptide binding]; other site 266264010850 putative sulfite oxidase subunit YedZ; Reviewed; Region: PRK05419 266264010851 TMAO/DMSO reductase; Reviewed; Region: PRK05363 266264010852 YedY_like molybdopterin cofactor (Moco) binding domain, a subgroup of the sulfite oxidase (SO) family of molybdopterin binding domains. Escherichia coli YedY has been propsed to form a heterodimer, consisting of a soluble catalytic subunit termed YedY; Region: YedY_like_Moco; cd02107 266264010853 Moco binding site; other site 266264010854 metal coordination site [ion binding]; other site 266264010855 Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662 266264010856 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 266264010857 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 266264010858 DNA binding residues [nucleotide binding] 266264010859 Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640 266264010860 Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640 266264010861 cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144 266264010862 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125 266264010863 ResB-like family; Region: ResB; pfam05140 266264010864 Cytochrome c553 [Energy production and conversion]; Region: COG2863 266264010865 Cytochrome c; Region: Cytochrom_C; cl11414 266264010866 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 266264010867 G1 box; other site 266264010868 GTP/Mg2+ binding site [chemical binding]; other site 266264010869 Switch I region; other site 266264010870 G2 box; other site 266264010871 G3 box; other site 266264010872 Switch II region; other site 266264010873 G4 box; other site 266264010874 G5 box; other site 266264010875 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823 266264010876 dimer interface [polypeptide binding]; other site 266264010877 active site 266264010878 aspartate-rich active site metal binding site; other site 266264010879 allosteric magnesium binding site [ion binding]; other site 266264010880 Schiff base residues; other site 266264010881 Thermotoga maritima CorA-like family; Region: TmCorA-like; cd12822 266264010882 oligomer interface [polypeptide binding]; other site 266264010883 metal binding site [ion binding]; metal-binding site 266264010884 metal binding site [ion binding]; metal-binding site 266264010885 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 266264010886 putative Cl binding site [ion binding]; other site 266264010887 aspartate ring; other site 266264010888 basic sphincter; other site 266264010889 hydrophobic gate; other site 266264010890 periplasmic entrance; other site 266264010891 thiol:disulfide interchange protein precursor; Provisional; Region: dipZ; PRK00293 266264010892 Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412 266264010893 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 266264010894 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 266264010895 DsbD alpha interface [polypeptide binding]; other site 266264010896 catalytic residues [active] 266264010897 Uncharacterized protein involved in tolerance to divalent cations [Inorganic ion transport and metabolism]; Region: CutA; COG1324 266264010898 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 266264010899 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 266264010900 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 266264010901 alphaNTD homodimer interface [polypeptide binding]; other site 266264010902 alphaNTD - beta interaction site [polypeptide binding]; other site 266264010903 alphaNTD - beta' interaction site [polypeptide binding]; other site 266264010904 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 266264010905 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 266264010906 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 266264010907 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 266264010908 RNA binding surface [nucleotide binding]; other site 266264010909 30S ribosomal protein S11; Validated; Region: PRK05309 266264010910 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 266264010911 30S ribosomal protein S13; Region: bact_S13; TIGR03631 266264010912 Ribosomal protein L36; Region: Ribosomal_L36; pfam00444 266264010913 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 266264010914 rRNA binding site [nucleotide binding]; other site 266264010915 predicted 30S ribosome binding site; other site 266264010916 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 266264010917 SecY translocase; Region: SecY; pfam00344 266264010918 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 266264010919 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 266264010920 23S rRNA binding site [nucleotide binding]; other site 266264010921 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 266264010922 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 266264010923 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 266264010924 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 266264010925 5S rRNA interface [nucleotide binding]; other site 266264010926 23S rRNA interface [nucleotide binding]; other site 266264010927 L5 interface [polypeptide binding]; other site 266264010928 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 266264010929 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 266264010930 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 266264010931 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 266264010932 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 266264010933 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 266264010934 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 266264010935 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 266264010936 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 266264010937 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 266264010938 RNA binding site [nucleotide binding]; other site 266264010939 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 266264010940 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 266264010941 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 266264010942 23S rRNA interface [nucleotide binding]; other site 266264010943 putative translocon interaction site; other site 266264010944 signal recognition particle (SRP54) interaction site; other site 266264010945 L23 interface [polypeptide binding]; other site 266264010946 trigger factor interaction site; other site 266264010947 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 266264010948 23S rRNA interface [nucleotide binding]; other site 266264010949 5S rRNA interface [nucleotide binding]; other site 266264010950 putative antibiotic binding site [chemical binding]; other site 266264010951 L25 interface [polypeptide binding]; other site 266264010952 L27 interface [polypeptide binding]; other site 266264010953 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 266264010954 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 266264010955 G-X-X-G motif; other site 266264010956 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 266264010957 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 266264010958 putative translocon binding site; other site 266264010959 protein-rRNA interface [nucleotide binding]; other site 266264010960 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 266264010961 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 266264010962 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 266264010963 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 266264010964 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 266264010965 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 266264010966 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 266264010967 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 266264010968 FAD dependent oxidoreductase; Region: DAO; pfam01266 266264010969 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 266264010970 short chain dehydrogenase; Provisional; Region: PRK08265 266264010971 classical (c) SDRs; Region: SDR_c; cd05233 266264010972 NAD(P) binding site [chemical binding]; other site 266264010973 active site 266264010974 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 266264010975 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 266264010976 SnoaL-like domain; Region: SnoaL_2; pfam12680 266264010977 Helix-turn-helix domain; Region: HTH_18; pfam12833 266264010978 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 266264010979 elongation factor Tu; Reviewed; Region: PRK00049 266264010980 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 266264010981 G1 box; other site 266264010982 GEF interaction site [polypeptide binding]; other site 266264010983 GTP/Mg2+ binding site [chemical binding]; other site 266264010984 Switch I region; other site 266264010985 G2 box; other site 266264010986 G3 box; other site 266264010987 Switch II region; other site 266264010988 G4 box; other site 266264010989 G5 box; other site 266264010990 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 266264010991 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 266264010992 Antibiotic Binding Site [chemical binding]; other site 266264010993 elongation factor G; Reviewed; Region: PRK00007 266264010994 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 266264010995 G1 box; other site 266264010996 putative GEF interaction site [polypeptide binding]; other site 266264010997 GTP/Mg2+ binding site [chemical binding]; other site 266264010998 Switch I region; other site 266264010999 G2 box; other site 266264011000 G3 box; other site 266264011001 Switch II region; other site 266264011002 G4 box; other site 266264011003 G5 box; other site 266264011004 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 266264011005 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 266264011006 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 266264011007 30S ribosomal protein S7; Validated; Region: PRK05302 266264011008 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 266264011009 S17 interaction site [polypeptide binding]; other site 266264011010 S8 interaction site; other site 266264011011 16S rRNA interaction site [nucleotide binding]; other site 266264011012 streptomycin interaction site [chemical binding]; other site 266264011013 23S rRNA interaction site [nucleotide binding]; other site 266264011014 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 266264011015 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 266264011016 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 266264011017 ATP binding site [chemical binding]; other site 266264011018 putative Mg++ binding site [ion binding]; other site 266264011019 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 266264011020 nucleotide binding region [chemical binding]; other site 266264011021 ATP-binding site [chemical binding]; other site 266264011022 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 266264011023 HRDC domain; Region: HRDC; pfam00570 266264011024 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 266264011025 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266264011026 DNA-binding site [nucleotide binding]; DNA binding site 266264011027 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 266264011028 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266264011029 homodimer interface [polypeptide binding]; other site 266264011030 catalytic residue [active] 266264011031 Cytochrome c553 [Energy production and conversion]; Region: COG2863 266264011032 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 266264011033 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 266264011034 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 266264011035 Cytochrome D1 heme domain; Region: Cytochrom_D1; pfam02239 266264011036 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 266264011037 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 266264011038 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 266264011039 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 266264011040 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 266264011041 RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998 266264011042 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 266264011043 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 266264011044 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 266264011045 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 266264011046 DNA binding site [nucleotide binding] 266264011047 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 266264011048 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 266264011049 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 266264011050 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 266264011051 RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562 266264011052 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 266264011053 RPB3 interaction site [polypeptide binding]; other site 266264011054 RPB1 interaction site [polypeptide binding]; other site 266264011055 RPB11 interaction site [polypeptide binding]; other site 266264011056 RPB10 interaction site [polypeptide binding]; other site 266264011057 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 266264011058 core dimer interface [polypeptide binding]; other site 266264011059 peripheral dimer interface [polypeptide binding]; other site 266264011060 L10 interface [polypeptide binding]; other site 266264011061 L11 interface [polypeptide binding]; other site 266264011062 putative EF-Tu interaction site [polypeptide binding]; other site 266264011063 putative EF-G interaction site [polypeptide binding]; other site 266264011064 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 266264011065 23S rRNA interface [nucleotide binding]; other site 266264011066 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 266264011067 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 266264011068 mRNA/rRNA interface [nucleotide binding]; other site 266264011069 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 266264011070 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 266264011071 23S rRNA interface [nucleotide binding]; other site 266264011072 L7/L12 interface [polypeptide binding]; other site 266264011073 putative thiostrepton binding site; other site 266264011074 L25 interface [polypeptide binding]; other site 266264011075 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 266264011076 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 266264011077 putative homodimer interface [polypeptide binding]; other site 266264011078 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 266264011079 heterodimer interface [polypeptide binding]; other site 266264011080 homodimer interface [polypeptide binding]; other site 266264011081 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK05740 266264011082 elongation factor Tu; Reviewed; Region: PRK00049 266264011083 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 266264011084 G1 box; other site 266264011085 GEF interaction site [polypeptide binding]; other site 266264011086 GTP/Mg2+ binding site [chemical binding]; other site 266264011087 Switch I region; other site 266264011088 G2 box; other site 266264011089 G3 box; other site 266264011090 Switch II region; other site 266264011091 G4 box; other site 266264011092 G5 box; other site 266264011093 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 266264011094 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 266264011095 Antibiotic Binding Site [chemical binding]; other site 266264011096 Protein of unknown function, DUF488; Region: DUF488; cl01246 266264011097 Uncharacterized membrane protein, required for spore maturation in B.subtilis. [General function prediction only]; Region: SpmA; COG2715 266264011098 Uncharacterized membrane protein [Function unknown]; Region: SpmB; COG0700 266264011099 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 266264011100 Protein of unknown function (DUF1488); Region: DUF1488; pfam07369 266264011101 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 266264011102 Ligand Binding Site [chemical binding]; other site 266264011103 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_4; pfam14281 266264011104 putative transposase OrfB; Reviewed; Region: PHA02517 266264011105 HTH-like domain; Region: HTH_21; pfam13276 266264011106 Integrase core domain; Region: rve; pfam00665 266264011107 Integrase core domain; Region: rve_3; pfam13683 266264011108 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 266264011109 Transposase; Region: HTH_Tnp_1; cl17663 266264011110 LabA_like proteins; Region: LabA_like; cd06167 266264011111 putative metal binding site [ion binding]; other site 266264011112 Cytidine/deoxycytidylate deaminase (fragment) 266264011113 Transposase domain (DUF772); Region: DUF772; pfam05598 266264011114 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 266264011115 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 266264011116 Deoxycytidylate deaminase-related protein (fragment) 266264011117 MarR family; Region: MarR_2; pfam12802 266264011118 Bacterial multiubiquitin; Region: Bac_multiUb; pfam14452 266264011119 Bacterial multiubiquitin; Region: Bac_multiUb; pfam14452 266264011120 Bacterial multiubiquitin; Region: Bac_multiUb; pfam14452 266264011121 hypothetical protein; Provisional; Region: PRK06153 266264011122 Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cd01483 266264011123 ATP binding site [chemical binding]; other site 266264011124 substrate interface [chemical binding]; other site 266264011125 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 266264011126 TniQ; Region: TniQ; pfam06527 266264011127 transposase/IS protein; Provisional; Region: PRK09183 266264011128 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 266264011129 Walker A motif; other site 266264011130 ATP binding site [chemical binding]; other site 266264011131 Walker B motif; other site 266264011132 arginine finger; other site 266264011133 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 266264011134 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 266264011135 Integrase core domain; Region: rve; pfam00665 266264011136 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 266264011137 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 266264011138 putative active site [active] 266264011139 Uncharacterized conserved protein [Function unknown]; Region: COG4933 266264011140 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 266264011141 phenylacetate-CoA oxygenase subunit PaaA; Provisional; Region: paaA; PRK13778 266264011142 phenylacetate-CoA oxygenase, PaaG subunit; Region: PA_CoA_Oxy1; TIGR02156 266264011143 phenylacetate-CoA oxygenase subunit PaaB; Provisional; Region: paaB; PRK13781 266264011144 Phenylacetic acid catabolic protein; Region: PaaA_PaaC; pfam05138 266264011145 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 266264011146 phenylacetate-CoA oxygenase, PaaJ subunit; Region: PA_CoA_Oxy4; TIGR02159 266264011147 phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160 266264011148 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214 266264011149 FAD binding pocket [chemical binding]; other site 266264011150 FAD binding motif [chemical binding]; other site 266264011151 phosphate binding motif [ion binding]; other site 266264011152 beta-alpha-beta structure motif; other site 266264011153 NAD(p) ribose binding residues [chemical binding]; other site 266264011154 NAD binding pocket [chemical binding]; other site 266264011155 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site 266264011156 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 266264011157 catalytic loop [active] 266264011158 iron binding site [ion binding]; other site 266264011159 Domain of unknown function (DUF1835); Region: DUF1835; pfam08874 266264011160 Protein of unknown function; Region: DUF3658; pfam12395 266264011161 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 266264011162 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 266264011163 glutathione-regulated potassium-efflux system protein KefC; Provisional; Region: PRK03562 266264011164 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 266264011165 TrkA-N domain; Region: TrkA_N; pfam02254 266264011166 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 266264011167 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 266264011168 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 266264011169 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 266264011170 Coenzyme A binding pocket [chemical binding]; other site 266264011171 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 266264011172 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 266264011173 putative DNA binding site [nucleotide binding]; other site 266264011174 putative Zn2+ binding site [ion binding]; other site 266264011175 AsnC family; Region: AsnC_trans_reg; pfam01037 266264011176 EF-hand domain pair; Region: EF_hand_5; pfam13499 266264011177 Ca2+ binding site [ion binding]; other site 266264011178 EF hand; Region: EF_hand_3; pfam13202 266264011179 Type IV pilus biogenesis; Region: Pilus_PilP; pfam11356 266264011180 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 266264011181 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 266264011182 heme-binding site [chemical binding]; other site 266264011183 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 266264011184 FAD binding pocket [chemical binding]; other site 266264011185 FAD binding motif [chemical binding]; other site 266264011186 phosphate binding motif [ion binding]; other site 266264011187 beta-alpha-beta structure motif; other site 266264011188 NAD binding pocket [chemical binding]; other site 266264011189 Heme binding pocket [chemical binding]; other site 266264011190 Predicted transcriptional regulator [Transcription]; Region: COG1959 266264011191 Transcriptional regulator; Region: Rrf2; cl17282 266264011192 type II secretion system protein G; Region: typeII_sec_gspG; TIGR01710 266264011193 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 266264011194 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 266264011195 type II secretion system protein H; Region: typeII_sec_gspH; TIGR01708 266264011196 Type II secretion system (T2SS), protein I; Region: T2SI; pfam02501 266264011197 Type II secretory pathway, component PulJ [Intracellular trafficking and secretion]; Region: PulJ; COG4795 266264011198 Prokaryotic N-terminal methylation motif; Region: N_methyl; pfam07963 266264011199 Type II secretion system (T2SS), protein K; Region: T2SK; pfam03934 266264011200 Type II secretion system (T2SS), protein L; Region: T2SL; pfam05134 266264011201 GspL periplasmic domain; Region: GspL_C; cl14909 266264011202 Type II secretion system (T2SS), protein M; Region: T2SM; pfam04612 266264011203 Type II secretion system (T2SS), protein N; Region: T2SN; pfam01203 266264011204 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 266264011205 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 266264011206 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 266264011207 pilus (MSHA type) biogenesis protein MshL; Region: pilus_MshL; TIGR02519 266264011208 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 266264011209 type II secretion system protein E; Region: type_II_gspE; TIGR02533 266264011210 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 266264011211 Walker A motif; other site 266264011212 ATP binding site [chemical binding]; other site 266264011213 Walker B motif; other site 266264011214 type II secretion system protein F; Region: GspF; TIGR02120 266264011215 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 266264011216 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 266264011217 Uncharacterized subfamily of N-terminal LabA-like domains; Region: LabA_like_N_1; cd11297 266264011218 putative metal binding site [ion binding]; other site 266264011219 Uncharacterized conserved protein [Function unknown]; Region: COG1432 266264011220 C-terminal domain of LabA_like proteins; Region: LabA_like_C; cd10146 266264011221 indolepyruvate ferredoxin oxidoreductase; Validated; Region: PRK09193 266264011222 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 266264011223 dimer interface [polypeptide binding]; other site 266264011224 PYR/PP interface [polypeptide binding]; other site 266264011225 TPP binding site [chemical binding]; other site 266264011226 substrate binding site [chemical binding]; other site 266264011227 Thiamine pyrophosphate (TPP) family, IOR-alpha subfamily, TPP-binding module; composed of proteins similar to indolepyruvate ferredoxin oxidoreductase (IOR) alpha subunit. IOR catalyzes the oxidative decarboxylation of arylpyruvates, such as...; Region: TPP_IOR_alpha; cd02008 266264011228 TPP-binding site; other site 266264011229 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 266264011230 putative acetyltransferase; Provisional; Region: PRK03624 266264011231 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 266264011232 Coenzyme A binding pocket [chemical binding]; other site 266264011233 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_2; cd07253 266264011234 dimer interface [polypeptide binding]; other site 266264011235 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 266264011236 metal binding site [ion binding]; metal-binding site 266264011237 Major Facilitator Superfamily; Region: MFS_1; pfam07690 266264011238 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266264011239 putative substrate translocation pore; other site 266264011240 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 266264011241 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 266264011242 putative active site [active] 266264011243 metal binding site [ion binding]; metal-binding site 266264011244 metabolite-proton symporter; Region: 2A0106; TIGR00883 266264011245 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266264011246 putative substrate translocation pore; other site 266264011247 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 266264011248 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 266264011249 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 266264011250 Cation efflux family; Region: Cation_efflux; pfam01545 266264011251 Glucosylceramide synthase catalyzes the first glycosylation step of glycosphingolipid synthesis; Region: Glucosylceramide_synthase; cd02520 266264011252 ligand binding site; other site 266264011253 Glycosyl transferase family 21; Region: Glyco_transf_21; pfam13506 266264011254 hopanoid biosynthesis associated radical SAM protein HpnJ; Region: HpnJ; TIGR03471 266264011255 B12 binding domain; Region: B12-binding; pfam02310 266264011256 B12 binding site [chemical binding]; other site 266264011257 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 266264011258 FeS/SAM binding site; other site 266264011259 hopanoid biosynthesis associated protein HpnK and similar proteins; Region: YdjC_HpnK_like; cd10804 266264011260 putative active site [active] 266264011261 YdjC motif; other site 266264011262 Mg binding site [ion binding]; other site 266264011263 putative homodimer interface [polypeptide binding]; other site 266264011264 Uncharacterized protein family (UPF0104); Region: UPF0104; cl04219 266264011265 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 266264011266 Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26; Region: ACAD_fadE6_17_26; cd01152 266264011267 pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204 266264011268 FAD binding site [chemical binding]; other site 266264011269 substrate binding site [chemical binding]; other site 266264011270 catalytic base [active] 266264011271 pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203 266264011272 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 266264011273 active site 266264011274 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 266264011275 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 266264011276 substrate binding site [chemical binding]; other site 266264011277 oxyanion hole (OAH) forming residues; other site 266264011278 trimer interface [polypeptide binding]; other site 266264011279 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 266264011280 CoA-transferase family III; Region: CoA_transf_3; pfam02515 266264011281 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 266264011282 nitrogen assimilation transcriptional regulator; Provisional; Region: PRK11233 266264011283 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266264011284 The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433 266264011285 putative dimerization interface [polypeptide binding]; other site 266264011286 Thermus thermophilus SoxB and related proteins, N-terminal metallophosphatase domain; Region: MPP_SoxB_N; cd07411 266264011287 active site 266264011288 metal binding site [ion binding]; metal-binding site 266264011289 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 266264011290 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 266264011291 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 266264011292 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 266264011293 catalytic residues [active] 266264011294 Uncharacterized conserved protein [Function unknown]; Region: COG1416 266264011295 Sulphur oxidation protein SoxZ; Region: SoxZ; pfam08770 266264011296 Predicted secreted protein [Function unknown]; Region: COG5501 266264011297 Sulfur oxidation protein SoxY; Region: SoxY; pfam13501 266264011298 Cytochrome c; Region: Cytochrom_C; cl11414 266264011299 O-acetylserine/cysteine export protein; Provisional; Region: PRK11453 266264011300 EamA-like transporter family; Region: EamA; pfam00892 266264011301 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 266264011302 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 266264011303 Flavocytochrome c sulphide dehydrogenase, flavin-binding; Region: FCSD-flav_bind; pfam09242 266264011304 Cytochrome c; Region: Cytochrom_C; cl11414 266264011305 Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823 266264011306 BON domain; Region: BON; pfam04972 266264011307 BON domain; Region: BON; pfam04972 266264011308 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 266264011309 dimer interface [polypeptide binding]; other site 266264011310 active site 266264011311 hypothetical protein; Provisional; Region: PRK14673 266264011312 Predicted methyltransferases [General function prediction only]; Region: COG0313 266264011313 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 266264011314 putative SAM binding site [chemical binding]; other site 266264011315 putative homodimer interface [polypeptide binding]; other site 266264011316 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 266264011317 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 266264011318 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 266264011319 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 266264011320 active site 266264011321 catalytic site [active] 266264011322 substrate binding site [chemical binding]; other site 266264011323 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 266264011324 ArsC family; Region: ArsC; pfam03960 266264011325 catalytic residues [active] 266264011326 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 266264011327 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 266264011328 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 266264011329 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 266264011330 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 266264011331 Coenzyme A binding pocket [chemical binding]; other site 266264011332 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 266264011333 Uncharacterized conserved protein [Function unknown]; Region: COG2128 266264011334 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 266264011335 MarR family; Region: MarR_2; pfam12802 266264011336 M20 Zn-peptidases include exopeptidases; Region: M20_like; cd02697 266264011337 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK08651 266264011338 putative metal binding site [ion binding]; other site 266264011339 allantoate amidohydrolase; Reviewed; Region: PRK12890 266264011340 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 266264011341 active site 266264011342 metal binding site [ion binding]; metal-binding site 266264011343 dimer interface [polypeptide binding]; other site 266264011344 C4-dicarboxylate transporter DctA; Reviewed; Region: PRK13027 266264011345 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 266264011346 Transcriptional regulators [Transcription]; Region: GntR; COG1802 266264011347 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266264011348 DNA-binding site [nucleotide binding]; DNA binding site 266264011349 FCD domain; Region: FCD; pfam07729 266264011350 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266264011351 transcriptional activator TtdR; Provisional; Region: PRK09801 266264011352 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 266264011353 putative effector binding pocket; other site 266264011354 dimerization interface [polypeptide binding]; other site 266264011355 glyoxylate carboligase; Provisional; Region: PRK11269 266264011356 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 266264011357 PYR/PP interface [polypeptide binding]; other site 266264011358 dimer interface [polypeptide binding]; other site 266264011359 TPP binding site [chemical binding]; other site 266264011360 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 266264011361 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 266264011362 TPP-binding site [chemical binding]; other site 266264011363 Hydroxypyruvate isomerase [Carbohydrate transport and metabolism]; Region: Hfi; COG3622 266264011364 tartronate semialdehyde reductase; Provisional; Region: PRK15059 266264011365 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 266264011366 Putative glycerate kinase [Carbohydrate transport and metabolism]; Region: GckA; COG2379 266264011367 Domain of unknown function (DUF4147); Region: DUF4147; pfam13660 266264011368 MOFRL family; Region: MOFRL; pfam05161 266264011369 pyruvate kinase; Provisional; Region: PRK06247 266264011370 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 266264011371 domain interfaces; other site 266264011372 active site 266264011373 Predicted metalloprotease [General function prediction only]; Region: COG2321 266264011374 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 266264011375 nucleoside diphosphate kinase regulator; Provisional; Region: PRK05753 266264011376 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 266264011377 Cd(II)/Pb(II)-responsive transcriptional regulator; Region: CadR-PbrR; TIGR02047 266264011378 Helix-Turn-Helix DNA binding domain of the CadR and PbrR transcription regulators; Region: HTH_CadR-PbrR; cd04784 266264011379 DNA binding residues [nucleotide binding] 266264011380 dimer interface [polypeptide binding]; other site 266264011381 putative metal binding site [ion binding]; other site 266264011382 S-adenosylmethionine decarboxylase proenzyme, Bacillus form; Region: SAM_DCase_Bsu; TIGR03330 266264011383 Domain of unknown function (DUF4178); Region: DUF4178; pfam13785 266264011384 Domain of unknown function (DUF4178); Region: DUF4178; pfam13785 266264011385 Membrane protease subunit, stomatin/prohibitin family [Amino acid transport and metabolism]; Region: COG4260 266264011386 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_5; cd03408 266264011387 Short C-terminal domain; Region: SHOCT; pfam09851 266264011388 Predicted membrane protein [Function unknown]; Region: COG3766 266264011389 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 266264011390 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 266264011391 spermidine synthase; Provisional; Region: PRK03612 266264011392 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266264011393 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 266264011394 S-adenosylmethionine binding site [chemical binding]; other site 266264011395 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 266264011396 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 266264011397 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 266264011398 heat shock protein HtpX; Provisional; Region: PRK05457 266264011399 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 266264011400 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 266264011401 conserved cys residue [active] 266264011402 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 266264011403 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 266264011404 Cytochrome P450; Region: p450; pfam00067 266264011405 Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369 266264011406 Flavodoxin; Region: Flavodoxin_1; pfam00258 266264011407 These bifunctional proteins fuse N-terminal cytochrome p450 with a cytochrome p450 reductase (CYPOR). NADPH cytochrome p450 reductase serves as an electron donor in several oxygenase systems and is a component of nitric oxide synthases and methionine...; Region: bifunctional_CYPOR; cd06206 266264011408 FAD binding pocket [chemical binding]; other site 266264011409 FAD binding motif [chemical binding]; other site 266264011410 catalytic residues [active] 266264011411 NAD binding pocket [chemical binding]; other site 266264011412 phosphate binding motif [ion binding]; other site 266264011413 beta-alpha-beta structure motif; other site 266264011414 hypothetical protein; Provisional; Region: PRK09256 266264011415 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 266264011416 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 266264011417 FAD binding domain; Region: FAD_binding_4; pfam01565 266264011418 Berberine and berberine like; Region: BBE; pfam08031 266264011419 enoyl-CoA hydratase; Validated; Region: PRK08139 266264011420 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 266264011421 substrate binding site [chemical binding]; other site 266264011422 oxyanion hole (OAH) forming residues; other site 266264011423 trimer interface [polypeptide binding]; other site 266264011424 Cytochrome c; Region: Cytochrom_C; cl11414 266264011425 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 266264011426 Cytochrome c5 [Energy production and conversion]; Region: CycB; COG3245 266264011427 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 266264011428 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 266264011429 FeS/SAM binding site; other site 266264011430 HemN C-terminal domain; Region: HemN_C; pfam06969 266264011431 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 266264011432 Type I periplasmic binding domain of uncharacterized extracellular ligand-binding proteins; Region: PBP1_STKc_like; cd06326 266264011433 putative ligand binding site [chemical binding]; other site 266264011434 HAMP domain; Region: HAMP; pfam00672 266264011435 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 266264011436 dimer interface [polypeptide binding]; other site 266264011437 phosphorylation site [posttranslational modification] 266264011438 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266264011439 ATP binding site [chemical binding]; other site 266264011440 Mg2+ binding site [ion binding]; other site 266264011441 G-X-G motif; other site 266264011442 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 266264011443 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266264011444 active site 266264011445 phosphorylation site [posttranslational modification] 266264011446 intermolecular recognition site; other site 266264011447 dimerization interface [polypeptide binding]; other site 266264011448 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 266264011449 DNA binding site [nucleotide binding] 266264011450 ATP-dependent DNA helicase Rep; Region: rep; TIGR01074 266264011451 Part of AAA domain; Region: AAA_19; pfam13245 266264011452 Family description; Region: UvrD_C_2; pfam13538 266264011455 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 266264011456 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 266264011457 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 266264011458 lipoyl attachment site [posttranslational modification]; other site 266264011459 glycine dehydrogenase; Provisional; Region: PRK05367 266264011460 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 266264011461 tetramer interface [polypeptide binding]; other site 266264011462 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266264011463 catalytic residue [active] 266264011464 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 266264011465 tetramer interface [polypeptide binding]; other site 266264011466 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266264011467 catalytic residue [active] 266264011468 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 266264011469 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 266264011470 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 266264011471 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 266264011472 gamma-glutamyl:cysteine ligase; Provisional; Region: PRK13516 266264011473 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 266264011474 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 266264011475 Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783 266264011476 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 266264011477 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 266264011478 dimerization interface [polypeptide binding]; other site 266264011479 ligand binding site [chemical binding]; other site 266264011480 trifunctional transcriptional regulator/proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: putA; PRK11809 266264011481 Predicted transcriptional regulator [Transcription]; Region: COG3905 266264011482 Proline dehydrogenase [Amino acid transport and metabolism]; Region: PutA; COG0506 266264011483 Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125 266264011484 Glutamate binding site [chemical binding]; other site 266264011485 NAD binding site [chemical binding]; other site 266264011486 catalytic residues [active] 266264011487 primosome assembly protein PriA; Validated; Region: PRK05580 266264011488 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 266264011489 ATP binding site [chemical binding]; other site 266264011490 putative Mg++ binding site [ion binding]; other site 266264011491 helicase superfamily c-terminal domain; Region: HELICc; smart00490 266264011492 methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252 266264011493 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 266264011494 substrate binding site [chemical binding]; other site 266264011495 active site 266264011496 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 266264011497 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 266264011498 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 266264011499 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 266264011500 gamma subunit interface [polypeptide binding]; other site 266264011501 epsilon subunit interface [polypeptide binding]; other site 266264011502 LBP interface [polypeptide binding]; other site 266264011503 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 266264011504 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 266264011505 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 266264011506 alpha subunit interaction interface [polypeptide binding]; other site 266264011507 Walker A motif; other site 266264011508 ATP binding site [chemical binding]; other site 266264011509 Walker B motif; other site 266264011510 inhibitor binding site; inhibition site 266264011511 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 266264011512 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 266264011513 core domain interface [polypeptide binding]; other site 266264011514 delta subunit interface [polypeptide binding]; other site 266264011515 epsilon subunit interface [polypeptide binding]; other site 266264011516 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 266264011517 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 266264011518 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 266264011519 beta subunit interaction interface [polypeptide binding]; other site 266264011520 Walker A motif; other site 266264011521 ATP binding site [chemical binding]; other site 266264011522 Walker B motif; other site 266264011523 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 266264011524 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 266264011525 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 266264011526 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 266264011527 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 266264011528 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 266264011529 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 266264011530 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 266264011531 ATP synthase I chain; Region: ATP_synt_I; cl09170 266264011532 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 266264011533 ParB-like nuclease domain; Region: ParB; smart00470 266264011534 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 266264011535 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 266264011536 P-loop; other site 266264011537 Magnesium ion binding site [ion binding]; other site 266264011538 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 266264011539 Magnesium ion binding site [ion binding]; other site 266264011540 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 266264011541 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 266264011542 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 266264011543 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 266264011544 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 266264011545 N-formylglutamate amidohydrolase; Region: FGase; pfam05013 266264011546 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 266264011547 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 266264011548 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266264011549 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 266264011550 dimerization interface [polypeptide binding]; other site 266264011551 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 266264011552 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 266264011553 Walker A/P-loop; other site 266264011554 ATP binding site [chemical binding]; other site 266264011555 Q-loop/lid; other site 266264011556 ABC transporter signature motif; other site 266264011557 Walker B; other site 266264011558 D-loop; other site 266264011559 H-loop/switch region; other site 266264011560 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 266264011561 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 266264011562 TM-ABC transporter signature motif; other site 266264011563 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 266264011564 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 266264011565 Walker A/P-loop; other site 266264011566 ATP binding site [chemical binding]; other site 266264011567 Q-loop/lid; other site 266264011568 ABC transporter signature motif; other site 266264011569 Walker B; other site 266264011570 D-loop; other site 266264011571 H-loop/switch region; other site 266264011572 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 266264011573 TM-ABC transporter signature motif; other site 266264011574 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 266264011575 Type I periplasmic binding component of ABC (ATPase Binding Cassette)-type transport systems that are predicted to be involved in uptake of amino acids; Region: PBP1_ABC-type_HAAT_like; cd06333 266264011576 putative ligand binding site [chemical binding]; other site 266264011577 hypothetical protein; Provisional; Region: PRK10621 266264011578 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 266264011579 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 266264011580 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 266264011581 TM-ABC transporter signature motif; other site 266264011582 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 266264011583 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 266264011584 TM-ABC transporter signature motif; other site 266264011585 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 266264011586 Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327 266264011587 putative ligand binding site [chemical binding]; other site 266264011588 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 266264011589 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 266264011590 Walker A/P-loop; other site 266264011591 ATP binding site [chemical binding]; other site 266264011592 Q-loop/lid; other site 266264011593 ABC transporter signature motif; other site 266264011594 Walker B; other site 266264011595 D-loop; other site 266264011596 H-loop/switch region; other site 266264011597 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 266264011598 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 266264011599 Walker A/P-loop; other site 266264011600 ATP binding site [chemical binding]; other site 266264011601 Q-loop/lid; other site 266264011602 ABC transporter signature motif; other site 266264011603 Walker B; other site 266264011604 D-loop; other site 266264011605 H-loop/switch region; other site 266264011606 choline dehydrogenase; Validated; Region: PRK02106 266264011607 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 266264011608 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 266264011609 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 266264011610 Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044 266264011611 Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108 266264011612 DNA binding residues [nucleotide binding] 266264011613 dimer interface [polypeptide binding]; other site 266264011614 copper binding site [ion binding]; other site 266264011615 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 266264011616 metal-binding site [ion binding] 266264011617 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 266264011618 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 266264011619 metal-binding site [ion binding] 266264011620 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 266264011621 Soluble P-type ATPase [General function prediction only]; Region: COG4087 266264011622 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 266264011623 metal-binding site [ion binding] 266264011624 Outer membrane protein W [Cell envelope biogenesis, outer membrane]; Region: OmpW; COG3047 266264011625 ornithine cyclodeaminase; Validated; Region: PRK07340 266264011626 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 266264011627 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 266264011628 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 266264011629 active site 266264011630 catalytic tetrad [active] 266264011631 penicillin-binding protein 1C; Region: PBP_1c; TIGR02073 266264011632 Transglycosylase; Region: Transgly; pfam00912 266264011633 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 266264011634 Penicillin-Binding Protein C-terminus Family; Region: BiPBP_C; pfam06832 266264011635 Predicted membrane protein [Function unknown]; Region: COG3714 266264011636 MG2 domain; Region: A2M_N; pfam01835 266264011637 Alpha-2-macroglobulin family N-terminal region; Region: A2M_N_2; pfam07703 266264011638 Alpha-2-macroglobulin family; Region: A2M; pfam00207 266264011639 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 266264011640 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 266264011641 AsnC family; Region: AsnC_trans_reg; pfam01037 266264011642 Prokaryotic phenylalanine-4-hydroxylase (pro_PheOH); a member of the biopterin-dependent aromatic amino acid hydroxylase family of non-heme, iron(II)-dependent enzymes that also includes the eukaryotic proteins, phenylalanine-4-hydroxylase (eu_PheOH); Region: pro_PheOH; cd03348 266264011643 cofactor binding site; other site 266264011644 metal binding site [ion binding]; metal-binding site 266264011645 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH_subfamily_b; cd00914 266264011646 aromatic arch; other site 266264011647 DCoH dimer interaction site [polypeptide binding]; other site 266264011648 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 266264011649 DCoH tetramer interaction site [polypeptide binding]; other site 266264011650 substrate binding site [chemical binding]; other site 266264011651 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 266264011652 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266264011653 active site 266264011654 phosphorylation site [posttranslational modification] 266264011655 intermolecular recognition site; other site 266264011656 dimerization interface [polypeptide binding]; other site 266264011657 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 266264011658 DNA binding site [nucleotide binding] 266264011659 Two-component sensor kinase N-terminal; Region: 2CSK_N; pfam08521 266264011660 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 266264011661 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 266264011662 dimer interface [polypeptide binding]; other site 266264011663 phosphorylation site [posttranslational modification] 266264011664 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266264011665 ATP binding site [chemical binding]; other site 266264011666 Mg2+ binding site [ion binding]; other site 266264011667 G-X-G motif; other site 266264011668 SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Region: SET; smart00317 266264011669 Proteins containing SET domain [General function prediction only]; Region: COG2940 266264011670 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 266264011671 IHF dimer interface [polypeptide binding]; other site 266264011672 IHF - DNA interface [nucleotide binding]; other site 266264011673 Uncharacterized protein conserved in bacteria (DUF2272); Region: DUF2272; pfam10030 266264011674 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cl00200 266264011675 amphipathic channel; other site 266264011676 Asn-Pro-Ala signature motifs; other site 266264011677 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 266264011678 TRAP-type mannitol/chloroaromatic compound transport system, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT1; COG4663 266264011679 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 266264011680 Predicted permeases [General function prediction only]; Region: RarD; COG2962 266264011681 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 266264011682 active site 266264011683 DNA polymerase IV; Validated; Region: PRK02406 266264011684 DNA binding site [nucleotide binding] 266264011685 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 266264011686 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266264011687 putative substrate translocation pore; other site 266264011688 putative diguanylate cyclase YedQ; Provisional; Region: PRK15426 266264011689 Cache domain; Region: Cache_1; pfam02743 266264011690 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 266264011691 metal binding site [ion binding]; metal-binding site 266264011692 active site 266264011693 I-site; other site 266264011694 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 266264011695 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 266264011696 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 266264011697 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3333 266264011698 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 266264011699 CoenzymeA binding site [chemical binding]; other site 266264011700 subunit interaction site [polypeptide binding]; other site 266264011701 PHB binding site; other site 266264011702 Patatin-like phospholipase; Region: Patatin; pfam01734 266264011703 active site 266264011704 nucleophile elbow; other site 266264011705 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 266264011706 glutathione reductase; Validated; Region: PRK06116 266264011707 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 266264011708 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 266264011709 putative DNA-binding transcriptional regulator; Provisional; Region: PRK09791 266264011710 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266264011711 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 266264011712 dimerization interface [polypeptide binding]; other site 266264011713 amidase; Provisional; Region: PRK07487 266264011714 Amidase; Region: Amidase; cl11426 266264011715 Protein of unknown function (DUF3311); Region: DUF3311; pfam11755 266264011716 Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322 266264011717 Na binding site [ion binding]; other site 266264011718 Response regulator receiver domain; Region: Response_reg; pfam00072 266264011719 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266264011720 active site 266264011721 phosphorylation site [posttranslational modification] 266264011722 intermolecular recognition site; other site 266264011723 dimerization interface [polypeptide binding]; other site 266264011724 Predicted transcriptional regulator [Transcription]; Region: COG3636; cl17681 266264011725 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 266264011726 dimerization interface [polypeptide binding]; other site 266264011727 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 266264011728 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 266264011729 dimer interface [polypeptide binding]; other site 266264011730 phosphorylation site [posttranslational modification] 266264011731 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266264011732 ATP binding site [chemical binding]; other site 266264011733 Mg2+ binding site [ion binding]; other site 266264011734 G-X-G motif; other site 266264011735 Domain of unknown function (DUF4390); Region: DUF4390; pfam14334 266264011736 16S rRNA methyltransferase B; Provisional; Region: PRK10901 266264011737 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 266264011738 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 266264011739 S-adenosylmethionine binding site [chemical binding]; other site 266264011740 M48 family peptidase; Provisional; Region: PRK03001 266264011741 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 266264011742 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 266264011743 putative active site [active] 266264011744 substrate binding site [chemical binding]; other site 266264011745 putative cosubstrate binding site; other site 266264011746 catalytic site [active] 266264011747 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 266264011748 substrate binding site [chemical binding]; other site 266264011749 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 266264011750 active site 266264011751 catalytic residues [active] 266264011752 metal binding site [ion binding]; metal-binding site 266264011753 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 266264011754 Uncharacterized protein containing LysM domain [Function unknown]; Region: XkdP; COG1652 266264011755 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 266264011756 DNA protecting protein DprA; Region: dprA; TIGR00732 266264011757 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 266264011758 catalytic residues [active] 266264011759 DNA topoisomerase III; Validated; Region: PRK08173 266264011760 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 266264011761 active site 266264011762 putative interdomain interaction site [polypeptide binding]; other site 266264011763 putative metal-binding site [ion binding]; other site 266264011764 putative nucleotide binding site [chemical binding]; other site 266264011765 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 266264011766 domain I; other site 266264011767 DNA binding groove [nucleotide binding] 266264011768 phosphate binding site [ion binding]; other site 266264011769 domain II; other site 266264011770 domain III; other site 266264011771 nucleotide binding site [chemical binding]; other site 266264011772 catalytic site [active] 266264011773 domain IV; other site 266264011774 C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342 266264011775 C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342 266264011776 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266264011777 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266264011778 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 266264011779 putative effector binding pocket; other site 266264011780 dimerization interface [polypeptide binding]; other site 266264011781 Protein of unknown function (DUF466); Region: DUF466; pfam04328 266264011782 carbon starvation protein A; Provisional; Region: PRK15015 266264011783 Carbon starvation protein CstA; Region: CstA; pfam02554 266264011784 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 266264011785 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4564 266264011786 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 266264011787 Histidine kinase; Region: HisKA_3; pfam07730 266264011788 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266264011789 ATP binding site [chemical binding]; other site 266264011790 Mg2+ binding site [ion binding]; other site 266264011791 G-X-G motif; other site 266264011792 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 266264011793 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266264011794 active site 266264011795 phosphorylation site [posttranslational modification] 266264011796 intermolecular recognition site; other site 266264011797 dimerization interface [polypeptide binding]; other site 266264011798 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 266264011799 DNA binding residues [nucleotide binding] 266264011800 dimerization interface [polypeptide binding]; other site 266264011801 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819 266264011802 active site 266264011803 substrate-binding site [chemical binding]; other site 266264011804 metal-binding site [ion binding] 266264011805 GTP binding site [chemical binding]; other site 266264011806 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 266264011807 Putative D-3-Phosphoglycerate Dehydrogenases; Region: PGDH_like_1; cd12169 266264011808 dimerization interface [polypeptide binding]; other site 266264011809 NAD binding site [chemical binding]; other site 266264011810 ligand binding site [chemical binding]; other site 266264011811 catalytic site [active] 266264011812 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cl17302 266264011813 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 266264011814 MOSC domain; Region: MOSC; pfam03473 266264011815 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 266264011816 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 266264011817 HlyD family secretion protein; Region: HlyD_3; pfam13437 266264011818 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 266264011819 Protein export membrane protein; Region: SecD_SecF; cl14618 266264011820 Protein of unknown function, DUF399; Region: DUF399; pfam04187 266264011821 Two-component sensor kinase N-terminal; Region: 2CSK_N; pfam08521 266264011822 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 266264011823 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 266264011824 dimer interface [polypeptide binding]; other site 266264011825 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266264011826 ATP binding site [chemical binding]; other site 266264011827 Mg2+ binding site [ion binding]; other site 266264011828 G-X-G motif; other site 266264011829 transcriptional regulatory protein TctD; Provisional; Region: PRK15479 266264011830 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266264011831 active site 266264011832 phosphorylation site [posttranslational modification] 266264011833 intermolecular recognition site; other site 266264011834 dimerization interface [polypeptide binding]; other site 266264011835 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 266264011836 DNA binding site [nucleotide binding] 266264011837 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 266264011838 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 266264011839 DNA-binding transcriptional repressor AcrR; Provisional; Region: PRK10668 266264011840 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 266264011841 MAATS-type transcriptional repressor, C-terminal region; Region: TetR_C_2; pfam08361 266264011842 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 266264011843 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 266264011844 HlyD family secretion protein; Region: HlyD_3; pfam13437 266264011845 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 266264011846 Protein export membrane protein; Region: SecD_SecF; cl14618 266264011847 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 266264011848 Outer membrane protein W [Cell envelope biogenesis, outer membrane]; Region: OmpW; COG3047 266264011849 Protein of unknown function (DUF2957); Region: DUF2957; pfam11170 266264011850 Protein of unknown function (DUF2957); Region: DUF2957; pfam11170 266264011851 Protein of unknown function (DUF1571); Region: DUF1571; pfam07608 266264011852 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 266264011853 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 266264011854 GMC oxidoreductase; Region: GMC_oxred_N; pfam00732 266264011855 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 266264011856 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 266264011857 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 266264011858 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266264011859 short chain dehydrogenase; Provisional; Region: PRK05650 266264011860 NAD(P) binding site [chemical binding]; other site 266264011861 active site 266264011862 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 266264011863 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 266264011864 catalytic site [active] 266264011865 Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118 266264011866 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687 266264011867 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg2; cd04778 266264011868 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 266264011869 DNA binding residues [nucleotide binding] 266264011870 putative dimer interface [polypeptide binding]; other site 266264011871 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266264011872 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266264011873 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 266264011874 dimerization interface [polypeptide binding]; other site 266264011875 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 266264011876 Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like; uncharacterized subgroup; Region: M14_ASTE_ASPA_like_7; cd06910 266264011877 putative active site [active] 266264011878 Zn binding site [ion binding]; other site 266264011879 tRNA_anti-like; Region: tRNA_anti-like; pfam12869 266264011880 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 266264011881 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 266264011882 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 266264011883 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 266264011884 trmE is a tRNA modification GTPase; Region: trmE; cd04164 266264011885 G1 box; other site 266264011886 GTP/Mg2+ binding site [chemical binding]; other site 266264011887 Switch I region; other site 266264011888 G2 box; other site 266264011889 Switch II region; other site 266264011890 G3 box; other site 266264011891 G4 box; other site 266264011892 G5 box; other site 266264011893 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 266264011894 CHAD domain; Region: CHAD; pfam05235 266264011895 Trans-aconitate methyltransferase [General function prediction only]; Region: Tam; COG4106 266264011896 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 266264011897 S-adenosylmethionine binding site [chemical binding]; other site 266264011898 membrane protein insertase; Provisional; Region: PRK01318 266264011899 Domain of unknown function (DUF4380); Region: DUF4380; pfam14315 266264011900 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 266264011901 hypothetical protein; Validated; Region: PRK00041 266264011902 Ribonuclease P; Region: Ribonuclease_P; cl00457 266264011903 hypothetical protein 266264011904 Plasmid encoded RepA protein; Region: RepA_C; pfam04796 266264011905 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 266264011906 DNA-binding site [nucleotide binding]; DNA binding site 266264011907 RNA-binding motif; other site 266264011908 ParA-like protein; Provisional; Region: PHA02518 266264011909 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 266264011910 P-loop; other site 266264011911 Magnesium ion binding site [ion binding]; other site 266264011912 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 266264011913 ParB-like nuclease domain; Region: ParBc; pfam02195 266264011914 Phage integrase protein; Region: DUF3701; pfam12482 266264011915 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235 266264011916 ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909 266264011917 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 266264011918 DNA binding residues [nucleotide binding] 266264011919 dimerization interface [polypeptide binding]; other site 266264011920 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 266264011921 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 266264011922 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 266264011923 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 266264011924 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266264011925 NAD(P) binding site [chemical binding]; other site 266264011926 active site 266264011927 lipid-transfer protein; Provisional; Region: PRK08256 266264011928 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 266264011929 active site 266264011930 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 266264011931 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 266264011932 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 266264011933 acyl-activating enzyme (AAE) consensus motif; other site 266264011934 acyl-activating enzyme (AAE) consensus motif; other site 266264011935 putative AMP binding site [chemical binding]; other site 266264011936 putative active site [active] 266264011937 putative CoA binding site [chemical binding]; other site 266264011938 Isochorismatase family; Region: Isochorismatase; pfam00857 266264011939 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 266264011940 catalytic triad [active] 266264011941 dimer interface [polypeptide binding]; other site 266264011942 conserved cis-peptide bond; other site 266264011943 PBP superfamily domain; Region: PBP_like_2; cl17296 266264011944 Protein of unknown function (DUF1653); Region: DUF1653; pfam07866 266264011945 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4339 266264011946 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 266264011947 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 266264011948 DNA binding residues [nucleotide binding] 266264011949 dimerization interface [polypeptide binding]; other site 266264011950 aminopeptidase P (fragment) 266264011951 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 266264011952 active site 266264011953 Undecaprenyl-phosphate glucose phosphotransferase; Region: WcaJ_sugtrans; TIGR03023 266264011954 Bacterial sugar transferase; Region: Bac_transf; pfam02397 266264011955 acyl carrier protein; Provisional; Region: PRK07081 266264011956 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 266264011957 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 266264011958 active site 266264011959 Gly_His_Pro_Ser_Thr_tRNA synthetase class II core domain. This domain is the core catalytic domain of tRNA synthetases of the subgroup containing glycyl, histidyl, prolyl, seryl and threonyl tRNA synthetases. It is primarily responsible for ATP-dependent...; Region: Gly_His_Pro_Ser_Thr_tRS_core; cd00670 266264011960 dimer interface [polypeptide binding]; other site 266264011961 motif 1; other site 266264011962 active site 266264011963 motif 2; other site 266264011964 motif 3; other site 266264011965 Domain of unknown function (DUF1839); Region: DUF1839; pfam08893 266264011966 Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism]; Region: LacZ; COG3250 266264011967 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 266264011968 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 266264011969 ligand binding site [chemical binding]; other site 266264011970 flexible hinge region; other site 266264011971 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 266264011972 non-specific DNA interactions [nucleotide binding]; other site 266264011973 DNA binding site [nucleotide binding] 266264011974 sequence specific DNA binding site [nucleotide binding]; other site 266264011975 putative cAMP binding site [chemical binding]; other site 266264011976 Domain of unknown function (DUF1839); Region: DUF1839; pfam08893 266264011977 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 266264011978 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 266264011979 Substrate binding site; other site 266264011980 Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050 266264011981 tyrosine kinase; Provisional; Region: PRK11519 266264011982 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 266264011983 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 266264011984 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 266264011985 exosortase A system-associated hydrolase 1; Region: hydr1_PEP; TIGR03100 266264011986 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 266264011987 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 266264011988 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 266264011989 NADP binding site [chemical binding]; other site 266264011990 active site 266264011991 steroid binding site; other site 266264011992 Protein of unknown function (DUF2029); Region: DUF2029; pfam09594 266264011993 tyrosine kinase; Provisional; Region: PRK11519 266264011994 Chain length determinant protein; Region: Wzz; pfam02706 266264011995 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 266264011996 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 266264011997 Low molecular weight phosphatase family; Region: LMWPc; cd00115 266264011998 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 266264011999 active site 266264012000 Periplasmic protein involved in polysaccharide export, contains SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596 266264012001 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 266264012002 SLBB domain; Region: SLBB; pfam10531 266264012003 SLBB domain; Region: SLBB; pfam10531 266264012004 YdjC-family proteins; Region: YdjC_like; cd10788 266264012005 putative active site [active] 266264012006 YdjC motif; other site 266264012007 Mg binding site [ion binding]; other site 266264012008 putative homodimer interface [polypeptide binding]; other site 266264012009 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 266264012010 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 266264012011 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 266264012012 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 266264012013 putative acyl transferase; Provisional; Region: PRK10502 266264012014 wcaF-like: This group is composed of the protein product of the E. coli wcaF gene and similar proteins. WcaF is part of the gene cluster responsible for the biosynthesis of the extracellular polysaccharide colanic acid. The wcaF protein is predicted to...; Region: LbH_wcaF_like; cd05825 266264012015 putative trimer interface [polypeptide binding]; other site 266264012016 putative active site [active] 266264012017 putative substrate binding site [chemical binding]; other site 266264012018 putative CoA binding site [chemical binding]; other site 266264012019 putative glycosyl transferase; Provisional; Region: PRK10307 266264012020 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 266264012021 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 266264012022 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 266264012023 NADP binding site [chemical binding]; other site 266264012024 active site 266264012025 putative substrate binding site [chemical binding]; other site 266264012026 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 266264012027 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 266264012028 NADP-binding site; other site 266264012029 homotetramer interface [polypeptide binding]; other site 266264012030 substrate binding site [chemical binding]; other site 266264012031 homodimer interface [polypeptide binding]; other site 266264012032 active site 266264012033 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 266264012034 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 266264012035 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 266264012036 DNA binding residues [nucleotide binding] 266264012037 dimerization interface [polypeptide binding]; other site 266264012038 cyanate hydratase; Validated; Region: PRK02866 266264012039 Cyanase C-terminal domain. Cyanase (Cyanate lyase) is responsible for the hydrolysis of cyanate. It catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide. This allows organisms that possess the enzyme to overcome the...; Region: Cyanase_C; cd00559 266264012040 oligomer interface [polypeptide binding]; other site 266264012041 active site 266264012042 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 266264012043 active site 266264012044 3-isopropylmalate dehydratase small subunit; Reviewed; Region: leuD; PRK00439 266264012045 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 266264012046 substrate binding site [chemical binding]; other site 266264012047 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 266264012048 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 266264012049 substrate binding site [chemical binding]; other site 266264012050 ligand binding site [chemical binding]; other site 266264012051 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 266264012052 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 266264012053 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266264012054 DNA-binding site [nucleotide binding]; DNA binding site 266264012055 UTRA domain; Region: UTRA; pfam07702 266264012056 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39G; cd02423 266264012057 putative active site [active] 266264012058 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 266264012059 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 266264012060 Type I periplasmic binding domain of uncharacterized extracellular ligand-binding proteins; Region: PBP1_STKc_like; cd06326 266264012061 putative ligand binding site [chemical binding]; other site 266264012062 gluconate 5-dehydrogenase; Provisional; Region: PRK06124 266264012063 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266264012064 NAD(P) binding site [chemical binding]; other site 266264012065 active site 266264012066 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266264012067 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266264012068 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 266264012069 putative dimerization interface [polypeptide binding]; other site 266264012070 Protein of unknown function (DUF1446); Region: DUF1446; pfam07287 266264012071 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 266264012072 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 266264012073 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 266264012074 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 266264012075 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 266264012076 Coenzyme A binding pocket [chemical binding]; other site 266264012077 AMP nucleosidase; Provisional; Region: PRK08292 266264012078 Bacterial AMP nucleoside phosphorylase N-terminus; Region: AMNp_N; pfam10423 266264012079 Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775 266264012080 Outer membrane protein W [Cell envelope biogenesis, outer membrane]; Region: OmpW; COG3047 266264012081 2-isopropylmalate synthase; Validated; Region: PRK03739 266264012082 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 266264012083 active site 266264012084 catalytic residues [active] 266264012085 metal binding site [ion binding]; metal-binding site 266264012086 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 266264012087 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 266264012088 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 266264012089 G1 box; other site 266264012090 GTP/Mg2+ binding site [chemical binding]; other site 266264012091 Switch I region; other site 266264012092 G2 box; other site 266264012093 G3 box; other site 266264012094 Switch II region; other site 266264012095 G4 box; other site 266264012096 G5 box; other site 266264012097 Nucleoside recognition; Region: Gate; pfam07670 266264012098 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 266264012099 Nucleoside recognition; Region: Gate; pfam07670 266264012100 FeoA domain; Region: FeoA; pfam04023 266264012101 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266264012102 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 266264012103 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to regulators involved in the catabolism of aromatic compounds, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like_2; cd08448 266264012104 putative dimerization interface [polypeptide binding]; other site 266264012105 putative substrate binding pocket [chemical binding]; other site 266264012106 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 266264012107 active site 266264012108 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 266264012109 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 266264012110 CoA-transferase family III; Region: CoA_transf_3; pfam02515 266264012111 glycolate transporter; Provisional; Region: PRK09695 266264012112 L-lactate permease; Region: Lactate_perm; cl00701 266264012113 Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139 266264012114 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 266264012115 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 266264012116 Domain of unknown function (DUF3390); Region: DUF3390; pfam11870 266264012117 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 266264012118 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 266264012119 Cysteine-rich domain; Region: CCG; pfam02754 266264012120 Cysteine-rich domain; Region: CCG; pfam02754 266264012121 Transcriptional regulators [Transcription]; Region: FadR; COG2186 266264012122 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266264012123 DNA-binding site [nucleotide binding]; DNA binding site 266264012124 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 266264012125 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 266264012126 ethanolamine ammonia lyase large subunit; Provisional; Region: PRK15067 266264012127 Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; pfam06751 266264012128 ethanolamine ammonia-lyase small subunit; Provisional; Region: PRK05465 266264012129 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cd04332 266264012130 putative deacylase active site [active] 266264012131 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266264012132 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266264012133 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 266264012134 putative effector binding pocket; other site 266264012135 dimerization interface [polypeptide binding]; other site 266264012136 alpha-ketoglutarate transporter; Provisional; Region: PRK10406 266264012137 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266264012138 putative substrate translocation pore; other site 266264012139 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 266264012140 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 266264012141 active site 266264012142 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 266264012143 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 266264012144 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 266264012145 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 266264012146 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 266264012147 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 266264012148 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 266264012149 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 266264012150 AlkA N-terminal domain; Region: AlkA_N; pfam06029 266264012151 3-methyl-adenine DNA glycosylase II; Provisional; Region: PRK10308 266264012152 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 266264012153 minor groove reading motif; other site 266264012154 helix-hairpin-helix signature motif; other site 266264012155 substrate binding pocket [chemical binding]; other site 266264012156 active site 266264012157 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 266264012158 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 266264012159 DNA binding site [nucleotide binding] 266264012160 active site 266264012161 2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258 266264012162 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 266264012163 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 266264012164 LysE type translocator; Region: LysE; cl00565 266264012165 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 266264012166 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266264012167 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 266264012168 dimerization interface [polypeptide binding]; other site 266264012169 Flagellar regulator YcgR; Region: YcgR; pfam07317 266264012170 c-di-GMP-binding protein [Signal transduction mechanisms]; Region: COG5581 266264012171 PilZ domain; Region: PilZ; pfam07238 266264012172 beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431 266264012173 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 266264012174 Bacterial transcriptional regulator; Region: IclR; pfam01614 266264012175 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 266264012176 Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205 266264012177 active site 266264012178 nucleophile elbow; other site 266264012179 Surface antigen; Region: Bac_surface_Ag; pfam01103 266264012180 Oxidoreductase-like protein, N-terminal; Region: Oxidored-like; pfam09791 266264012181 NAD-dependent deacetylase; Provisional; Region: PRK05333 266264012182 SIRT4: Eukaryotic and prokaryotic group (class2) which includes human sirtuin SIRT4 and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein...; Region: SIRT4; cd01409 266264012183 NAD+ binding site [chemical binding]; other site 266264012184 substrate binding site [chemical binding]; other site 266264012185 Zn binding site [ion binding]; other site 266264012186 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 266264012187 hypothetical protein; Provisional; Region: PRK04325 266264012188 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 266264012189 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 266264012190 dimer interface [polypeptide binding]; other site 266264012191 argininosuccinate synthase; Validated; Region: PRK05370 266264012192 argininosuccinate synthase; Provisional; Region: PRK13820 266264012193 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 266264012194 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 266264012195 active site 266264012196 catalytic tetrad [active] 266264012197 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 266264012198 Transglycosylase; Region: Transgly; cl17702 266264012199 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 266264012200 Predicted membrane protein [Function unknown]; Region: COG2261 266264012201 elongation factor G; Reviewed; Region: PRK00007 266264012202 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 266264012203 G1 box; other site 266264012204 putative GEF interaction site [polypeptide binding]; other site 266264012205 GTP/Mg2+ binding site [chemical binding]; other site 266264012206 Switch I region; other site 266264012207 G2 box; other site 266264012208 G3 box; other site 266264012209 Switch II region; other site 266264012210 G4 box; other site 266264012211 G5 box; other site 266264012212 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 266264012213 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 266264012214 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 266264012215 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 266264012216 NodB motif; other site 266264012217 active site 266264012218 catalytic site [active] 266264012219 metal binding site [ion binding]; metal-binding site 266264012220 Protein of unknown function (DUF3047); Region: DUF3047; pfam11249 266264012221 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 266264012222 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 266264012223 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 266264012224 dimer interface [polypeptide binding]; other site 266264012225 putative CheW interface [polypeptide binding]; other site 266264012226 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 266264012227 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 266264012228 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 266264012229 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 266264012230 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 266264012231 GlpE sulfurtransferase (ST) and homologs are members of the Rhodanese Homology Domain superfamily. Unlike other rhodanese sulfurtransferases, GlpE is a single domain protein but indications are that it functions as a dimer. The active site contains a...; Region: GlpE_ST; cd01444 266264012232 active site residue [active] 266264012233 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086 266264012234 putative binding surface; other site 266264012235 active site 266264012236 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 266264012237 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266264012238 active site 266264012239 phosphorylation site [posttranslational modification] 266264012240 intermolecular recognition site; other site 266264012241 dimerization interface [polypeptide binding]; other site 266264012242 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 266264012243 DNA binding residues [nucleotide binding] 266264012244 dimerization interface [polypeptide binding]; other site 266264012245 OsmC-like protein; Region: OsmC; pfam02566 266264012246 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 266264012247 GIY-YIG motif/motif A; other site 266264012248 putative active site [active] 266264012249 putative metal binding site [ion binding]; other site 266264012250 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 266264012251 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 266264012252 MarR family; Region: MarR; pfam01047 266264012253 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 266264012254 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 266264012255 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 266264012256 protein binding site [polypeptide binding]; other site 266264012257 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 266264012258 protein binding site [polypeptide binding]; other site 266264012259 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266264012260 Major Facilitator Superfamily; Region: MFS_1; pfam07690 266264012261 putative substrate translocation pore; other site 266264012262 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266264012263 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 266264012264 MarR family; Region: MarR_2; cl17246 266264012265 Domain of unknown function (DUF3488); Region: DUF3488; pfam11992 266264012266 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 266264012267 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 266264012268 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 266264012269 Protein of unknown function DUF58; Region: DUF58; pfam01882 266264012270 MoxR-like ATPases [General function prediction only]; Region: COG0714 266264012271 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 266264012272 Walker A motif; other site 266264012273 ATP binding site [chemical binding]; other site 266264012274 Walker B motif; other site 266264012275 arginine finger; other site 266264012276 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 266264012277 Transcriptional regulators [Transcription]; Region: GntR; COG1802 266264012278 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266264012279 DNA-binding site [nucleotide binding]; DNA binding site 266264012280 FCD domain; Region: FCD; pfam07729 266264012281 CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated; Region: PRK07609 266264012282 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 266264012283 catalytic loop [active] 266264012284 iron binding site [ion binding]; other site 266264012285 NAD(P)H dependent flavin oxidoreductases use flavin as a substrate in mediating electron transfer from iron complexes or iron proteins. Structurally similar to ferredoxin reductases, but with only 15% sequence identity, flavin reductases reduce FAD, FMN; Region: flavin_oxioreductase; cd06189 266264012286 FAD binding pocket [chemical binding]; other site 266264012287 FAD binding motif [chemical binding]; other site 266264012288 phosphate binding motif [ion binding]; other site 266264012289 beta-alpha-beta structure motif; other site 266264012290 NAD binding pocket [chemical binding]; other site 266264012291 Domain of unknown function (DUF336); Region: DUF336; pfam03928 266264012292 Bacillus subtilis NADP+-dependent alpha-ketoglutaric semialdehyde dehydrogenase ycbD-like; Region: ALDH_KGSADH-YcbD; cd07097 266264012293 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 266264012294 NAD(P) binding site [chemical binding]; other site 266264012295 catalytic residues [active] 266264012296 TENA/THI-4/PQQC family; Region: TENA_THI-4; cl15243 266264012297 Predicted ornithine cyclodeaminase, mu-crystallin homolog [Amino acid transport and metabolism]; Region: COG2423 266264012298 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 266264012299 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 266264012300 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 266264012301 catalytic loop [active] 266264012302 iron binding site [ion binding]; other site 266264012303 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 266264012304 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 266264012305 catalytic loop [active] 266264012306 iron binding site [ion binding]; other site 266264012307 beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431 266264012308 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 266264012309 Bacterial transcriptional regulator; Region: IclR; pfam01614 266264012310 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266264012311 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266264012312 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 266264012313 putative effector binding pocket; other site 266264012314 dimerization interface [polypeptide binding]; other site 266264012315 YGGT family; Region: YGGT; pfam02325 266264012316 YGGT family; Region: YGGT; pfam02325 266264012317 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 266264012318 MarR family; Region: MarR_2; pfam12802 266264012319 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 266264012320 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 266264012321 Dodecin; Region: Dodecin; pfam07311 266264012322 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 266264012323 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 266264012324 Flp/Fap pilin component; Region: Flp_Fap; pfam04964 266264012325 TadE-like protein; Region: TadE; pfam07811 266264012326 Domains similar to fish antifreeze type III protein; Region: SAF; cl00555 266264012327 Flp pilus assembly protein, secretin CpaC [Intracellular trafficking and secretion]; Region: CpaC; COG4964 266264012328 Pilus formation protein N terminal region; Region: T2SS-T3SS_pil_N; pfam13629 266264012329 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 266264012330 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266264012331 active site 266264012332 phosphorylation site [posttranslational modification] 266264012333 intermolecular recognition site; other site 266264012334 AAA domain; Region: AAA_31; pfam13614 266264012335 This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111 266264012336 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 266264012337 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 266264012338 ATP binding site [chemical binding]; other site 266264012339 Walker A motif; other site 266264012340 hexamer interface [polypeptide binding]; other site 266264012341 Walker B motif; other site 266264012342 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 266264012343 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 266264012344 Flp pilus assembly protein TadC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: TadC; COG2064 266264012345 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 266264012346 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 266264012347 binding surface 266264012348 TPR motif; other site 266264012349 TPR repeat; Region: TPR_11; pfam13414 266264012350 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 266264012351 binding surface 266264012352 TPR motif; other site 266264012353 Protein of unknown function (DUF3613); Region: DUF3613; pfam12266 266264012354 Putative Tad-like Flp pilus-assembly; Region: Tad_C; pfam09977 266264012355 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 266264012356 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 266264012357 Walker A motif; other site 266264012358 ATP binding site [chemical binding]; other site 266264012359 Walker B motif; other site 266264012360 arginine finger; other site 266264012361 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 266264012362 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 266264012363 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 266264012364 active site 266264012365 metal binding site [ion binding]; metal-binding site 266264012366 DNA binding site [nucleotide binding] 266264012367 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 266264012368 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 266264012369 AAA domain; Region: AAA_23; pfam13476 266264012370 Walker A/P-loop; other site 266264012371 ATP binding site [chemical binding]; other site 266264012372 Q-loop/lid; other site 266264012373 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 266264012374 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 266264012375 ABC transporter signature motif; other site 266264012376 Walker B; other site 266264012377 D-loop; other site 266264012378 H-loop/switch region; other site 266264012379 hypothetical protein; Provisional; Region: PRK09133 266264012380 M20 Peptidase, carboxypeptidase yscS-like; Region: M20_yscS_like; cd05675 266264012381 putative metal binding site [ion binding]; other site 266264012382 Coenzyme A transferase; Region: CoA_trans; cl17247 266264012383 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 266264012384 beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050 266264012385 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 266264012386 dimer interface [polypeptide binding]; other site 266264012387 active site 266264012388 short chain dehydrogenase; Provisional; Region: PRK07577 266264012389 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266264012390 NAD(P) binding site [chemical binding]; other site 266264012391 active site 266264012392 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 266264012393 Predicted transcriptional regulators [Transcription]; Region: COG1695 266264012394 Transcriptional regulator PadR-like family; Region: PadR; cl17335 266264012395 Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400 266264012396 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 266264012397 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 266264012398 FMN binding site [chemical binding]; other site 266264012399 substrate binding site [chemical binding]; other site 266264012400 putative catalytic residue [active] 266264012401 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 266264012402 Int/Topo IB signature motif; other site 266264012403 DNA binding site [nucleotide binding] 266264012404 active site 266264012405 UDP-glucose 4-epimerase; Region: PLN02240 266264012406 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 266264012407 NAD binding site [chemical binding]; other site 266264012408 homodimer interface [polypeptide binding]; other site 266264012409 active site 266264012410 substrate binding site [chemical binding]; other site 266264012411 H-NS histone family; Region: Histone_HNS; pfam00816 266264012412 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 266264012413 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 266264012414 dimer interface [polypeptide binding]; other site 266264012415 ligand binding site [chemical binding]; other site 266264012416 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 266264012417 dimerization interface [polypeptide binding]; other site 266264012418 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 266264012419 dimer interface [polypeptide binding]; other site 266264012420 putative CheW interface [polypeptide binding]; other site 266264012421 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 266264012422 metal binding site [ion binding]; metal-binding site 266264012423 active site 266264012424 I-site; other site 266264012425 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 266264012426 Response regulator receiver domain; Region: Response_reg; pfam00072 266264012427 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266264012428 active site 266264012429 phosphorylation site [posttranslational modification] 266264012430 intermolecular recognition site; other site 266264012431 dimerization interface [polypeptide binding]; other site 266264012432 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 266264012433 putative CheA interaction surface; other site 266264012434 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 266264012435 PAS fold; Region: PAS_3; pfam08447 266264012436 putative active site [active] 266264012437 heme pocket [chemical binding]; other site 266264012438 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 266264012439 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 266264012440 dimerization interface [polypeptide binding]; other site 266264012441 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 266264012442 dimer interface [polypeptide binding]; other site 266264012443 putative CheW interface [polypeptide binding]; other site 266264012444 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 266264012445 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 266264012446 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 266264012447 dimer interface [polypeptide binding]; other site 266264012448 putative CheW interface [polypeptide binding]; other site 266264012449 Protein of unknown function (DUF4088); Region: DUF4088; pfam13317 266264012450 transcriptional activator FlhD; Provisional; Region: PRK02909 266264012451 transcriptional activator FlhC; Provisional; Region: PRK12722 266264012452 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 266264012453 flagellar motor protein MotA; Validated; Region: PRK09110 266264012454 flagellar motor protein MotB; Validated; Region: motB; PRK09041 266264012455 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 266264012456 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 266264012457 ligand binding site [chemical binding]; other site 266264012458 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 266264012459 putative binding surface; other site 266264012460 active site 266264012461 CheY binding; Region: CheY-binding; pfam09078 266264012462 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 266264012463 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266264012464 ATP binding site [chemical binding]; other site 266264012465 Mg2+ binding site [ion binding]; other site 266264012466 G-X-G motif; other site 266264012467 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 266264012468 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 266264012469 chemotaxis methyltransferase CheR; Provisional; Region: PRK10611 266264012470 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 266264012471 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 266264012472 S-adenosylmethionine binding site [chemical binding]; other site 266264012473 chemoreceptor glutamine deamidase CheD; Provisional; Region: PRK13489 266264012474 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 266264012475 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266264012476 active site 266264012477 phosphorylation site [posttranslational modification] 266264012478 intermolecular recognition site; other site 266264012479 dimerization interface [polypeptide binding]; other site 266264012480 CheB methylesterase; Region: CheB_methylest; pfam01339 266264012481 chemotaxis regulatory protein CheY; Provisional; Region: PRK10610 266264012482 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266264012483 active site 266264012484 phosphorylation site [posttranslational modification] 266264012485 intermolecular recognition site; other site 266264012486 dimerization interface [polypeptide binding]; other site 266264012487 chemotaxis regulator CheZ; Provisional; Region: PRK11166 266264012488 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624 266264012489 M20 Peptidases, Poly(aspartic acid) hydrolase-like proteins; Region: M20_PAAh_like; cd03896 266264012490 putative metal binding site [ion binding]; other site 266264012491 hypothetical protein; Provisional; Region: PRK11239 266264012492 Protein of unknown function, DUF480; Region: DUF480; pfam04337 266264012493 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 266264012494 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 266264012495 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 266264012496 FHIPEP family; Region: FHIPEP; pfam00771 266264012497 flagellar biosynthesis regulator FlhF; Provisional; Region: flhF; PRK14723 266264012498 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 266264012499 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 266264012500 Walker A/P-loop; other site 266264012501 ATP binding site [chemical binding]; other site 266264012502 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 266264012503 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 266264012504 flagellar biosynthesis sigma factor; Validated; Region: fliA; PRK06986 266264012505 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 266264012506 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 266264012507 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 266264012508 DNA binding residues [nucleotide binding] 266264012509 Flagellar protein FlhE; Region: FlhE; pfam06366 266264012510 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 266264012511 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 266264012512 trimer interface [polypeptide binding]; other site 266264012513 eyelet of channel; other site 266264012514 Amidohydrolase; Region: Amidohydro_2; pfam04909 266264012515 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2828 266264012516 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266264012517 pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424 266264012518 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266264012519 The C-terminal substrate binding domain of galactose-binding protein regulator contains the type 2 periplasmic binding fold; Region: PBP2_GbpR; cd08435 266264012520 putative dimerization interface [polypeptide binding]; other site 266264012521 benzoate transport; Region: 2A0115; TIGR00895 266264012522 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266264012523 putative substrate translocation pore; other site 266264012524 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266264012525 protocatechuate 4,5-dioxygenase; Provisional; Region: PRK13367 266264012526 The N-terminal domain of the Class III extradiol dioxygenase, Gallate Dioxygenase, which catalyzes the oxidization and subsequent ring-opening of gallate; Region: Gallate_Doxase_N; cd07950 266264012527 putative active site [active] 266264012528 Fe(II) binding site [ion binding]; other site 266264012529 putative dimer interface [polypeptide binding]; other site 266264012530 The C-terminal domain of Gallate Dioxygenase, which catalyzes the oxidization and subsequent ring-opening of gallate; Region: Gallate_dioxygenase_C; cd07923 266264012531 putative dimer interface [polypeptide binding]; other site 266264012532 putative N- and C-terminal domain interface [polypeptide binding]; other site 266264012533 Rubredoxin [Energy production and conversion]; Region: COG1773 266264012534 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 266264012535 iron binding site [ion binding]; other site 266264012536 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 266264012537 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 266264012538 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 266264012539 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266264012540 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266264012541 The C-terminal substrate binding domain of LysR-type transcriptional regulators that are involved in the catabolism of dinitrotoluene, naphthalene and gamma-hexachlorohexane; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_NahR_LinR_like; cd08459 266264012542 substrate binding pocket [chemical binding]; other site 266264012543 dimerization interface [polypeptide binding]; other site 266264012544 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 266264012545 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 266264012546 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 266264012547 dimer interface [polypeptide binding]; other site 266264012548 FMN binding site [chemical binding]; other site 266264012549 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_9; cd07245 266264012550 dimer interface [polypeptide binding]; other site 266264012551 putative metal binding site [ion binding]; other site 266264012552 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266264012553 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266264012554 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 266264012555 putative effector binding pocket; other site 266264012556 dimerization interface [polypeptide binding]; other site 266264012557 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 266264012558 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 266264012559 Sulfate transporter family; Region: Sulfate_transp; pfam00916 266264012560 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 266264012561 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 266264012562 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 266264012563 nucleoside/Zn binding site; other site 266264012564 dimer interface [polypeptide binding]; other site 266264012565 catalytic motif [active] 266264012566 Cache domain; Region: Cache_1; pfam02743 266264012567 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 266264012568 dimerization interface [polypeptide binding]; other site 266264012569 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 266264012570 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 266264012571 dimer interface [polypeptide binding]; other site 266264012572 putative CheW interface [polypeptide binding]; other site 266264012573 Predicted signal transduction protein containing sensor and EAL domains [Signal transduction mechanisms]; Region: COG4943 266264012574 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 266264012575 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 266264012576 xanthine permease; Region: pbuX; TIGR03173 266264012577 Water Stress and Hypersensitive response; Region: WHy; smart00769 266264012578 Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26; Region: ACAD_fadE6_17_26; cd01152 266264012579 pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204 266264012580 FAD binding site [chemical binding]; other site 266264012581 substrate binding site [chemical binding]; other site 266264012582 catalytic base [active] 266264012583 pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203 266264012584 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 266264012585 active site 266264012586 Monomeric isocitrate dehydrogenase [Energy production and conversion]; Region: Icd; COG2838 266264012587 Monomeric isocitrate dehydrogenase; Region: IDH; cl15383 266264012588 Predicted membrane protein [Function unknown]; Region: COG1289 266264012589 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 266264012590 FlgN protein; Region: FlgN; pfam05130 266264012591 flagellar biosynthesis anti-sigma factor FlgM; Region: FlgM_jcvi; TIGR03824 266264012592 SAF-like; Region: SAF_2; pfam13144 266264012593 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 266264012594 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680 266264012595 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182 266264012596 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 266264012597 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 266264012598 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 266264012599 flagellar basal body rod modification protein; Reviewed; Region: flgD; PRK06655 266264012600 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 266264012601 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 266264012602 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 266264012603 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 266264012604 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 266264012605 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 266264012606 flagellar basal body rod protein FlgF; Reviewed; Region: flgF; PRK12640 266264012607 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 266264012608 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 266264012609 flagellar basal body rod protein FlgG; Reviewed; Region: flgG; PRK12694 266264012610 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 266264012611 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 266264012612 flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK12697 266264012613 Flagellar basal body L-ring protein [Cell motility and secretion]; Region: FlgH; COG2063 266264012614 flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303 266264012615 flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622 266264012616 flagellar rod assembly protein/muramidase FlgJ; Provisional; Region: flgJ; PRK12712 266264012617 Rod binding protein; Region: Rod-binding; cl01626 266264012618 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 266264012619 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK06945 266264012620 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 266264012621 flagellar hook-associated protein FlgL; Reviewed; Region: flgL; PRK08870 266264012622 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 266264012623 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 266264012624 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 266264012625 metal binding site [ion binding]; metal-binding site 266264012626 active site 266264012627 I-site; other site 266264012628 Predicted transcriptional regulator [Transcription]; Region: COG2378 266264012629 WYL domain; Region: WYL; pfam13280 266264012630 Short C-terminal domain; Region: SHOCT; pfam09851 266264012631 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 266264012632 conserved hypothetical protein (fragment) 266264012633 Protein of unknown function (DUF1488); Region: DUF1488; pfam07369 266264012634 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 266264012635 YjgH belongs to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgH_like; cd02198 266264012636 homotrimer interaction site [polypeptide binding]; other site 266264012637 putative active site [active] 266264012638 acyl-CoA dehydrogenase; partial overlap 266264012639 Bacterial PH domain; Region: DUF304; pfam03703 266264012640 glutaminase; Reviewed; Region: PRK12356 266264012641 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 266264012642 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 266264012643 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 266264012644 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 266264012645 Uncharacterized protein conserved in bacteria (DUF2086); Region: DUF2086; pfam09859 266264012646 bifunctional DNA-binding transcriptional dual regulator/O6-methylguanine-DNA methyltransferase; Provisional; Region: PRK15435 266264012647 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 266264012648 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 266264012649 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 266264012650 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 266264012651 DNA binding site [nucleotide binding] 266264012652 active site 266264012653 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 266264012654 endonuclease III; Region: ENDO3c; smart00478 266264012655 minor groove reading motif; other site 266264012656 helix-hairpin-helix signature motif; other site 266264012657 substrate binding pocket [chemical binding]; other site 266264012658 active site 266264012659 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 266264012660 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 266264012661 DNA binding site [nucleotide binding] 266264012662 active site 266264012663 alpha-ketoglutarate-dependent dioxygenase AlkB; Provisional; Region: PRK15401 266264012664 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 266264012665 Transposase; Region: HTH_Tnp_1; cl17663 266264012666 putative transposase OrfB; Reviewed; Region: PHA02517 266264012667 HTH-like domain; Region: HTH_21; pfam13276 266264012668 Integrase core domain; Region: rve; pfam00665 266264012669 Integrase core domain; Region: rve_3; pfam13683 266264012670 TniQ; Region: TniQ; pfam06527 266264012671 TniQ; Region: TniQ; pfam06527 266264012672 Peptide arylation enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntE; COG1021 266264012673 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 266264012674 acyl-activating enzyme (AAE) consensus motif; other site 266264012675 AMP binding site [chemical binding]; other site 266264012676 active site 266264012677 CoA binding site [chemical binding]; other site 266264012678 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 266264012679 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 266264012680 Zn binding site [ion binding]; other site 266264012681 hypothetical protein; Provisional; Region: PRK06847 266264012682 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 266264012683 hypothetical protein; Provisional; Region: PRK07236 266264012684 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 266264012685 active site 266264012686 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 266264012687 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 266264012688 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266264012689 putative substrate translocation pore; other site 266264012690 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 266264012691 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 266264012692 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 266264012693 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 266264012694 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 266264012695 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 266264012696 trimer interface [polypeptide binding]; other site 266264012697 eyelet of channel; other site 266264012698 acyl-CoA synthetase; Validated; Region: PRK06188 266264012699 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 266264012700 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 266264012701 acyl-activating enzyme (AAE) consensus motif; other site 266264012702 putative AMP binding site [chemical binding]; other site 266264012703 putative active site [active] 266264012704 acyl-activating enzyme (AAE) consensus motif; other site 266264012705 putative CoA binding site [chemical binding]; other site 266264012706 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 266264012707 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 266264012708 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 266264012709 active site 266264012710 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 266264012711 CoA-transferase family III; Region: CoA_transf_3; pfam02515 266264012712 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 266264012713 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 266264012714 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266264012715 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to regulators involved in the catabolism of aromatic compounds, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like_2; cd08448 266264012716 putative dimerization interface [polypeptide binding]; other site 266264012717 putative substrate binding pocket [chemical binding]; other site 266264012718 lipase chaperone; Provisional; Region: PRK01294 266264012719 Proteobacterial lipase chaperone protein; Region: Lipase_chap; pfam03280 266264012720 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 266264012721 Lipase (class 2); Region: Lipase_2; pfam01674 266264012722 PGAP1-like protein; Region: PGAP1; pfam07819 266264012723 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 266264012724 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 266264012725 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 266264012726 acyl-activating enzyme (AAE) consensus motif; other site 266264012727 AMP binding site [chemical binding]; other site 266264012728 active site 266264012729 CoA binding site [chemical binding]; other site 266264012730 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266264012731 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266264012732 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_1; cd08421 266264012733 putative dimerization interface [polypeptide binding]; other site 266264012734 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 266264012735 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 266264012736 substrate binding site [chemical binding]; other site 266264012737 oxyanion hole (OAH) forming residues; other site 266264012738 trimer interface [polypeptide binding]; other site 266264012739 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 266264012740 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 266264012741 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 266264012742 acyl-activating enzyme (AAE) consensus motif; other site 266264012743 AMP binding site [chemical binding]; other site 266264012744 active site 266264012745 CoA binding site [chemical binding]; other site 266264012746 pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204 266264012747 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 266264012748 active site 266264012749 pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203 266264012750 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 266264012751 active site 266264012752 acetyl-CoA acetyltransferase; Provisional; Region: PRK08142 266264012753 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 266264012754 active site 266264012755 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 266264012756 DUF35 OB-fold domain; Region: DUF35; pfam01796 266264012757 Metal-binding domain of MaoC dehydratase; Region: zf-MaoC; pfam13452 266264012758 enoyl-CoA hydratase; Region: PLN02864 266264012759 HDE_HSD The R-hydratase-like hot dog fold of the 17-beta-hydroxysteriod dehydrogenase (HSD), and Hydratase-Dehydrogenase-Epimerase (HDE) proteins. Other enzymes with this fold include MaoC dehydratase, and the fatty acid synthase beta subunit; Region: HDE_HSD; cd03448 266264012760 dimer interaction site [polypeptide binding]; other site 266264012761 substrate-binding tunnel; other site 266264012762 active site 266264012763 catalytic site [active] 266264012764 substrate binding site [chemical binding]; other site 266264012765 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 266264012766 CoA-transferase family III; Region: CoA_transf_3; pfam02515 266264012767 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 266264012768 CoA-transferase family III; Region: CoA_transf_3; pfam02515 266264012769 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266264012770 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266264012771 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_1; cd08421 266264012772 putative dimerization interface [polypeptide binding]; other site 266264012773 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 266264012774 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 266264012775 active site 266264012776 catalytic site [active] 266264012777 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 266264012778 Peptidase M15; Region: Peptidase_M15_3; cl01194 266264012779 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3108 266264012780 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2989 266264012781 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 266264012782 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 266264012783 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 266264012784 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 266264012785 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 266264012786 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 266264012787 active site 266264012788 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 266264012789 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 266264012790 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 266264012791 acyl-activating enzyme (AAE) consensus motif; other site 266264012792 acyl-activating enzyme (AAE) consensus motif; other site 266264012793 putative AMP binding site [chemical binding]; other site 266264012794 putative active site [active] 266264012795 putative CoA binding site [chemical binding]; other site 266264012796 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 266264012797 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 266264012798 dimer interface [polypeptide binding]; other site 266264012799 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266264012800 catalytic residue [active] 266264012801 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 266264012802 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 266264012803 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 266264012804 esterase, PHB depolymerase family; Region: esterase_phb; TIGR01840 266264012805 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 266264012806 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 266264012807 catalytic loop [active] 266264012808 iron binding site [ion binding]; other site 266264012809 Uncharacterized conserved protein [Function unknown]; Region: COG1739 266264012810 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 266264012811 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 266264012812 Predicted phosphatase [General function prediction only]; Region: PhoX; COG3211 266264012813 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 266264012814 S-adenosylmethionine binding site [chemical binding]; other site 266264012815 HD domain; Region: HD_3; pfam13023 266264012816 RES domain; Region: RES; pfam08808 266264012817 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 266264012818 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 266264012819 nitrogen assimilation transcriptional regulator; Provisional; Region: PRK11233 266264012820 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266264012821 The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433 266264012822 putative dimerization interface [polypeptide binding]; other site 266264012823 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 266264012824 CoA-transferase family III; Region: CoA_transf_3; pfam02515 266264012825 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 266264012826 Outer membrane efflux protein; Region: OEP; pfam02321 266264012827 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 266264012828 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 266264012829 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 266264012830 E3 interaction surface; other site 266264012831 lipoyl attachment site [posttranslational modification]; other site 266264012832 HlyD family secretion protein; Region: HlyD_3; pfam13437 266264012833 heavy metal cation tricomponent efflux pump HmvA (CzcA-like) 266264012834 heavy metal cation tricomponent efflux pump HmvA (CzcA-like) 266264012835 GAF domain; Region: GAF; pfam01590 266264012836 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 266264012837 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 266264012838 metal binding site [ion binding]; metal-binding site 266264012839 active site 266264012840 I-site; other site 266264012841 Tannase and feruloyl esterase; Region: Tannase; pfam07519 266264012842 potential protein location (hypothetical protein) that overlaps protein (tannase and feruloyl esterase (alpha/beta hydrolase family)) 266264012843 hypothetical protein; Validated; Region: PRK06217 266264012844 Adenylate kinase and related kinases [Nucleotide transport and metabolism]; Region: Adk; COG0563 266264012845 Uncharacterized conserved protein [Function unknown]; Region: COG2128 266264012846 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 266264012847 RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636 266264012848 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 266264012849 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 266264012850 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 266264012851 S-adenosylmethionine binding site [chemical binding]; other site 266264012852 Protein of unknown function (DUF2789); Region: DUF2789; pfam10982 266264012853 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 266264012854 dimer interface [polypeptide binding]; other site 266264012855 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266264012856 TIGR01777 family protein; Region: yfcH 266264012857 NAD(P) binding site [chemical binding]; other site 266264012858 active site 266264012859 Protein of unknown function, DUF393; Region: DUF393; pfam04134 266264012860 Predicted integral membrane protein (DUF2269); Region: DUF2269; pfam10027 266264012861 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, subunit 9, 39 kDa, (NDUFA9) -like, atypical (a) SDRs; Region: NDUFA9_like_SDR_a; cd05271 266264012862 NADH(P)-binding; Region: NAD_binding_10; pfam13460 266264012863 putative NAD(P) binding site [chemical binding]; other site 266264012864 active site 266264012865 DoxX-like family; Region: DoxX_3; pfam13781 266264012866 Predicted transcriptional regulators [Transcription]; Region: COG1510 266264012867 MarR family; Region: MarR_2; pfam12802 266264012868 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 266264012869 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 266264012870 active site 266264012871 non-prolyl cis peptide bond; other site 266264012872 cytoplasmic membrane lipoprotein-28; Provisional; Region: PRK09861 266264012873 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 266264012874 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 266264012875 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 266264012876 Walker A/P-loop; other site 266264012877 ATP binding site [chemical binding]; other site 266264012878 Q-loop/lid; other site 266264012879 ABC transporter signature motif; other site 266264012880 Walker B; other site 266264012881 D-loop; other site 266264012882 H-loop/switch region; other site 266264012883 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266264012884 dimer interface [polypeptide binding]; other site 266264012885 conserved gate region; other site 266264012886 ABC-ATPase subunit interface; other site 266264012887 Dibenzothiophene (DBT) desulfurization enzyme C; Region: DszC; cd01163 266264012888 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 266264012889 Flavin binding site [chemical binding]; other site 266264012890 tRNA 2-selenouridine synthase; Provisional; Region: PRK11784 266264012891 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 266264012892 active site residue [active] 266264012893 AAA domain; Region: AAA_17; cl17253 266264012894 selenophosphate synthetase; Provisional; Region: PRK00943 266264012895 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195 266264012896 dimerization interface [polypeptide binding]; other site 266264012897 putative ATP binding site [chemical binding]; other site 266264012898 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 266264012899 Lysine efflux permease [General function prediction only]; Region: COG1279 266264012900 chromosome replication initiation inhibitor protein; Validated; Region: PRK03635 266264012901 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266264012902 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 266264012903 dimerization interface [polypeptide binding]; other site 266264012904 Chromate resistance exported protein; Region: Chrome_Resist; pfam09828 266264012905 Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059 266264012906 chromate transporter, chromate ion transporter (CHR) family; Region: 2A51; TIGR00937 266264012907 Chromate transporter; Region: Chromate_transp; pfam02417 266264012908 Chromate resistance exported protein; Region: Chrome_Resist; pfam09828 266264012909 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 266264012910 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 266264012911 Cytochrome P450; Region: p450; cl12078 266264012912 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 266264012913 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 266264012914 FMN binding site [chemical binding]; other site 266264012915 active site 266264012916 substrate binding site [chemical binding]; other site 266264012917 catalytic residue [active] 266264012918 LysR family transcriptional regulator; Provisional; Region: PRK14997 266264012919 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266264012920 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 266264012921 putative effector binding pocket; other site 266264012922 dimerization interface [polypeptide binding]; other site 266264012923 Predicted membrane protein [Function unknown]; Region: COG2855 266264012924 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 266264012925 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 266264012926 putative DNA binding site [nucleotide binding]; other site 266264012927 putative Zn2+ binding site [ion binding]; other site 266264012928 short chain dehydrogenase; Provisional; Region: PRK12937 266264012929 classical (c) SDRs; Region: SDR_c; cd05233 266264012930 NAD(P) binding site [chemical binding]; other site 266264012931 active site 266264012932 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266264012933 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266264012934 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 266264012935 putative effector binding pocket; other site 266264012936 dimerization interface [polypeptide binding]; other site 266264012937 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 266264012938 Zn2+ binding site [ion binding]; other site 266264012939 Mg2+ binding site [ion binding]; other site 266264012940 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 266264012941 Protein of unknown function (DUF1275); Region: DUF1275; pfam06912 266264012942 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 266264012943 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 266264012944 osmolarity response regulator; Provisional; Region: ompR; PRK09468 266264012945 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266264012946 active site 266264012947 phosphorylation site [posttranslational modification] 266264012948 intermolecular recognition site; other site 266264012949 dimerization interface [polypeptide binding]; other site 266264012950 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 266264012951 DNA binding site [nucleotide binding] 266264012952 osmolarity sensor protein; Provisional; Region: envZ; PRK09467 266264012953 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 266264012954 dimerization interface [polypeptide binding]; other site 266264012955 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 266264012956 dimer interface [polypeptide binding]; other site 266264012957 phosphorylation site [posttranslational modification] 266264012958 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266264012959 ATP binding site [chemical binding]; other site 266264012960 Mg2+ binding site [ion binding]; other site 266264012961 G-X-G motif; other site 266264012962 Domain of unknown function (DUF4410); Region: DUF4410; pfam14366 266264012963 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 266264012964 MarR family; Region: MarR_2; cl17246 266264012965 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 266264012966 dihydropyrimidinase; Provisional; Region: PRK13404 266264012967 D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine...; Region: D-HYD; cd01314 266264012968 tetramer interface [polypeptide binding]; other site 266264012969 active site 266264012970 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 266264012971 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266264012972 D-galactonate transporter; Region: 2A0114; TIGR00893 266264012973 putative substrate translocation pore; other site 266264012974 Transcriptional regulators [Transcription]; Region: GntR; COG1802 266264012975 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266264012976 DNA-binding site [nucleotide binding]; DNA binding site 266264012977 FCD domain; Region: FCD; pfam07729 266264012978 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 266264012979 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 266264012980 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 266264012981 homotrimer interaction site [polypeptide binding]; other site 266264012982 putative active site [active] 266264012983 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 266264012984 classical (c) SDRs; Region: SDR_c; cd05233 266264012985 NAD(P) binding site [chemical binding]; other site 266264012986 active site 266264012987 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266264012988 LysR family transcriptional regulator; Provisional; Region: PRK14997 266264012989 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 266264012990 putative effector binding pocket; other site 266264012991 dimerization interface [polypeptide binding]; other site 266264012992 Protein of unknown function (DUF535); Region: DUF535; pfam04393 266264012993 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 266264012994 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266264012995 DNA-binding site [nucleotide binding]; DNA binding site 266264012996 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 266264012997 hypothetical protein; Validated; Region: PRK07586 266264012998 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 266264012999 PYR/PP interface [polypeptide binding]; other site 266264013000 dimer interface [polypeptide binding]; other site 266264013001 TPP binding site [chemical binding]; other site 266264013002 Thiamine pyrophosphate (TPP) family, BFDC subfamily, TPP-binding module; composed of proteins similar to Pseudomonas putida benzoylformate decarboxylase (BFDC). P. putida BFDC plays a role in the mandelate pathway, catalyzing the conversion of...; Region: TPP_BFDC; cd02002 266264013003 TPP-binding site [chemical binding]; other site 266264013004 dimer interface [polypeptide binding]; other site 266264013005 Uncharacterized conserved protein [Function unknown]; Region: COG3777 266264013006 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 266264013007 SAV4209 is a Streptomyces avermitilis protein with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. The alpha- and...; Region: SAV4209; cd03455 266264013008 putative active site [active] 266264013009 putative catalytic site [active] 266264013010 MmgE/PrpD family; Region: MmgE_PrpD; cl00912 266264013011 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 266264013012 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 266264013013 active site 266264013014 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 266264013015 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266264013016 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266264013017 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_1; cd08421 266264013018 putative dimerization interface [polypeptide binding]; other site 266264013019 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266264013020 NAD(P) binding site [chemical binding]; other site 266264013021 short chain dehydrogenase; Provisional; Region: PRK07060 266264013022 active site 266264013023 PrkA family serine protein kinase; Provisional; Region: PRK15455 266264013024 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 266264013025 hypothetical protein; Provisional; Region: PRK05325 266264013026 SpoVR family protein; Provisional; Region: PRK11767 266264013027 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 266264013028 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 266264013029 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 266264013030 DNA binding residues [nucleotide binding] 266264013031 dimerization interface [polypeptide binding]; other site 266264013032 Mechanosensitive ion channel; Region: MS_channel; pfam00924 266264013033 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 266264013034 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 266264013035 catalytic core [active] 266264013036 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 266264013037 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 266264013038 Transcriptional regulator [Transcription]; Region: IclR; COG1414 266264013039 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 266264013040 CoA binding domain; Region: CoA_binding_2; pfam13380 266264013041 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 266264013042 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 266264013043 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 266264013044 Uncharacterized conserved protein [Function unknown]; Region: COG5361 266264013045 Protein of unknown function (DUF1254); Region: DUF1254; pfam06863 266264013046 Protein of unknown function (DUF1214); Region: DUF1214; cl08447 266264013047 Uncharacterized conserved protein [Function unknown]; Region: COG5361 266264013048 Protein of unknown function (DUF1254); Region: DUF1254; pfam06863 266264013049 Protein of unknown function (DUF1214); Region: DUF1214; cl08447 266264013050 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 266264013051 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 266264013052 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 266264013053 active site 266264013054 catalytic site [active] 266264013055 substrate binding site [chemical binding]; other site 266264013056 nucleotide excision repair endonuclease; Provisional; Region: PRK10545 266264013057 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 266264013058 GIY-YIG motif/motif A; other site 266264013059 active site 266264013060 catalytic site [active] 266264013061 putative DNA binding site [nucleotide binding]; other site 266264013062 metal binding site [ion binding]; metal-binding site 266264013063 multidrug efflux system transporter AcrA; Provisional; Region: PRK15030 266264013064 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 266264013065 HlyD family secretion protein; Region: HlyD_3; pfam13437 266264013066 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 266264013067 Protein export membrane protein; Region: SecD_SecF; cl14618 266264013068 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 266264013069 Arginase family; Region: Arginase; cd09989 266264013070 agmatinase; Region: agmatinase; TIGR01230 266264013071 active site 266264013072 Mn binding site [ion binding]; other site 266264013073 oligomer interface [polypeptide binding]; other site 266264013074 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 266264013075 hypothetical protein 266264013076 AAA domain; Region: AAA_22; pfam13401 266264013077 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 266264013078 Walker A motif; other site 266264013079 ATP binding site [chemical binding]; other site 266264013080 Walker B motif; other site 266264013081 arginine finger; other site 266264013082 Integrase core domain; Region: rve; pfam00665 266264013083 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 266264013084 transcriptional regulatory protein TctD; Provisional; Region: PRK15479 266264013085 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266264013086 active site 266264013087 phosphorylation site [posttranslational modification] 266264013088 intermolecular recognition site; other site 266264013089 dimerization interface [polypeptide binding]; other site 266264013090 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 266264013091 DNA binding site [nucleotide binding] 266264013092 Two-component sensor kinase N-terminal; Region: 2CSK_N; pfam08521 266264013093 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 266264013094 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 266264013095 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 266264013096 dimer interface [polypeptide binding]; other site 266264013097 phosphorylation site [posttranslational modification] 266264013098 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266264013099 ATP binding site [chemical binding]; other site 266264013100 Mg2+ binding site [ion binding]; other site 266264013101 G-X-G motif; other site 266264013102 Major Facilitator Superfamily; Region: MFS_1; pfam07690 266264013103 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266264013104 putative substrate translocation pore; other site 266264013105 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266264013106 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 266264013107 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 266264013108 putative Zn2+ binding site [ion binding]; other site 266264013109 putative DNA binding site [nucleotide binding]; other site 266264013110 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 266264013111 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 266264013112 catalytic triad [active] 266264013113 transcriptional regulator RcsB; Provisional; Region: PRK10840 266264013114 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266264013115 active site 266264013116 phosphorylation site [posttranslational modification] 266264013117 intermolecular recognition site; other site 266264013118 dimerization interface [polypeptide binding]; other site 266264013119 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 266264013120 DNA binding residues [nucleotide binding] 266264013121 dimerization interface [polypeptide binding]; other site 266264013122 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266264013123 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266264013124 Transposase IS3/IS911 (fragment) 266264013125 putative transposase OrfB; Reviewed; Region: PHA02517 266264013126 HTH-like domain; Region: HTH_21; pfam13276 266264013127 Integrase core domain; Region: rve; pfam00665 266264013128 Integrase core domain; Region: rve_3; pfam13683 266264013129 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 266264013130 Transposase; Region: HTH_Tnp_1; cl17663 266264013131 Transposase IS3/IS911 (fragment) 266264013132 Protein of unknown function (DUF3300); Region: DUF3300; pfam11737 266264013133 Protein of unknown function (DUF2950); Region: DUF2950; pfam11453 266264013134 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 266264013135 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 266264013136 ligand binding site [chemical binding]; other site 266264013137 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 266264013138 putative switch regulator; other site 266264013139 non-specific DNA interactions [nucleotide binding]; other site 266264013140 DNA binding site [nucleotide binding] 266264013141 sequence specific DNA binding site [nucleotide binding]; other site 266264013142 putative cAMP binding site [chemical binding]; other site 266264013143 Esterase PHB depolymerase; Region: Esterase_phd; pfam10503 266264013144 metabolite-proton symporter; Region: 2A0106; TIGR00883 266264013145 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266264013146 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266264013147 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 266264013148 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 266264013149 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 266264013150 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 266264013151 AsmA-like C-terminal region; Region: AsmA_1; pfam13109 266264013152 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cl02931 266264013153 ligand binding site [chemical binding]; other site 266264013154 Rubredoxin [Energy production and conversion]; Region: COG1773 266264013155 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 266264013156 iron binding site [ion binding]; other site 266264013157 5-bromo-4-chloroindolyl phosphate hydrolysis protein; Region: Halogen_Hydrol; cl02059 266264013158 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 266264013159 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 266264013160 Cytochrome c; Region: Cytochrom_C; cl11414 266264013161 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 266264013162 cytochrome c oxidase, subunit I; Region: CtaD_CoxA; TIGR02891 266264013163 Heme-copper oxidase subunit III subfamily. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane; Region: Heme_Cu_Oxidase_III_2; cd02865 266264013164 Subunit I/III interface [polypeptide binding]; other site 266264013165 Heme-copper oxidase subunit III subfamily. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane; Region: Heme_Cu_Oxidase_III_1; cd02864 266264013166 Subunit I/III interface [polypeptide binding]; other site 266264013167 Predicted small integral membrane protein [Function unknown]; Region: COG5605 266264013168 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4320 266264013169 Uncharacterized protein conserved in bacteria (DUF2252); Region: DUF2252; pfam10009 266264013170 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 266264013171 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 266264013172 tetramerization interface [polypeptide binding]; other site 266264013173 NAD(P) binding site [chemical binding]; other site 266264013174 catalytic residues [active] 266264013175 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 266264013176 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138 266264013177 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 266264013178 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3333 266264013179 Transcriptional regulator PadR-like family; Region: PadR; cl17335 266264013180 Peptidase M66; Region: Peptidase_M66; pfam10462 266264013181 Response regulator receiver domain; Region: Response_reg; pfam00072 266264013182 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266264013183 active site 266264013184 phosphorylation site [posttranslational modification] 266264013185 intermolecular recognition site; other site 266264013186 dimerization interface [polypeptide binding]; other site 266264013187 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 266264013188 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 266264013189 metal binding site [ion binding]; metal-binding site 266264013190 active site 266264013191 I-site; other site 266264013192 chemotaxis-specific methylesterase; Provisional; Region: PRK12555 266264013193 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266264013194 phosphorylation site [posttranslational modification] 266264013195 intermolecular recognition site; other site 266264013196 CheB methylesterase; Region: CheB_methylest; pfam01339 266264013197 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 266264013198 putative binding surface; other site 266264013199 active site 266264013200 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 266264013201 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266264013202 ATP binding site [chemical binding]; other site 266264013203 Mg2+ binding site [ion binding]; other site 266264013204 G-X-G motif; other site 266264013205 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 266264013206 Response regulator receiver domain; Region: Response_reg; pfam00072 266264013207 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266264013208 active site 266264013209 phosphorylation site [posttranslational modification] 266264013210 intermolecular recognition site; other site 266264013211 dimerization interface [polypeptide binding]; other site 266264013212 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 266264013213 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 266264013214 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 266264013215 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 266264013216 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 266264013217 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 266264013218 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 266264013219 dimerization interface [polypeptide binding]; other site 266264013220 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 266264013221 dimer interface [polypeptide binding]; other site 266264013222 putative CheW interface [polypeptide binding]; other site 266264013223 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 266264013224 metal binding site [ion binding]; metal-binding site 266264013225 active site 266264013226 I-site; other site 266264013227 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 266264013228 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_3; cd06336 266264013229 Receptor family ligand binding region; Region: ANF_receptor; pfam01094 266264013230 putative ligand binding site [chemical binding]; other site 266264013231 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 266264013232 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 266264013233 Walker A/P-loop; other site 266264013234 ATP binding site [chemical binding]; other site 266264013235 Q-loop/lid; other site 266264013236 ABC transporter signature motif; other site 266264013237 Walker B; other site 266264013238 D-loop; other site 266264013239 H-loop/switch region; other site 266264013240 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 266264013241 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 266264013242 Walker A/P-loop; other site 266264013243 ATP binding site [chemical binding]; other site 266264013244 Q-loop/lid; other site 266264013245 ABC transporter signature motif; other site 266264013246 Walker B; other site 266264013247 D-loop; other site 266264013248 H-loop/switch region; other site 266264013249 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 266264013250 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 266264013251 TM-ABC transporter signature motif; other site 266264013252 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 266264013253 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 266264013254 TM-ABC transporter signature motif; other site 266264013255 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 266264013256 Transcriptional regulator [Transcription]; Region: IclR; COG1414 266264013257 Bacterial transcriptional regulator; Region: IclR; pfam01614 266264013258 classical (c) SDRs; Region: SDR_c; cd05233 266264013259 NAD(P) binding site [chemical binding]; other site 266264013260 active site 266264013261 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 266264013262 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266264013263 Major Facilitator Superfamily; Region: MFS_1; pfam07690 266264013264 putative substrate translocation pore; other site 266264013265 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 266264013266 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 266264013267 dimer interface [polypeptide binding]; other site 266264013268 phosphorylation site [posttranslational modification] 266264013269 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266264013270 ATP binding site [chemical binding]; other site 266264013271 Mg2+ binding site [ion binding]; other site 266264013272 G-X-G motif; other site 266264013273 Response regulator receiver domain; Region: Response_reg; pfam00072 266264013274 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266264013275 active site 266264013276 phosphorylation site [posttranslational modification] 266264013277 intermolecular recognition site; other site 266264013278 dimerization interface [polypeptide binding]; other site 266264013279 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 266264013280 putative binding surface; other site 266264013281 active site 266264013282 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 266264013283 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266264013284 active site 266264013285 phosphorylation site [posttranslational modification] 266264013286 intermolecular recognition site; other site 266264013287 dimerization interface [polypeptide binding]; other site 266264013288 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 266264013289 DNA binding residues [nucleotide binding] 266264013290 dimerization interface [polypeptide binding]; other site 266264013291 Sensors of blue-light using FAD; Region: BLUF; pfam04940 266264013292 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 266264013293 GTP cyclohydrolase I; Provisional; Region: PLN03044 266264013294 active site 266264013295 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 266264013296 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 266264013297 transmembrane helices; other site 266264013298 Transglycosylase; Region: Transgly; pfam00912 266264013299 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 266264013300 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 266264013301 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 266264013302 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 266264013303 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 266264013304 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 266264013305 glucan biosynthesis protein G; Provisional; Region: mdoG; PRK13274 266264013306 Periplasmic glucan biosynthesis protein, MdoG; Region: MdoG; cl15433 266264013307 Protein of unknown function (DUF3820); Region: DUF3820; pfam12843 266264013308 Secretin and TonB N terminus short domain; Region: STN; smart00965 266264013309 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 266264013310 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 266264013311 N-terminal plug; other site 266264013312 ligand-binding site [chemical binding]; other site 266264013313 fec operon regulator FecR; Reviewed; Region: PRK09774 266264013314 FecR protein; Region: FecR; pfam04773 266264013315 RNA polymerase sigma factor; Provisional; Region: PRK12528 266264013316 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 266264013317 DNA binding residues [nucleotide binding] 266264013318 Response regulator receiver domain; Region: Response_reg; pfam00072 266264013319 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266264013320 active site 266264013321 phosphorylation site [posttranslational modification] 266264013322 intermolecular recognition site; other site 266264013323 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 266264013324 Aspartate racemase [Cell envelope biogenesis, outer membrane]; Region: RacX; COG1794 266264013325 aspartate racemase; Region: asp_race; TIGR00035 266264013326 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 266264013327 Helix-turn-helix domain; Region: HTH_38; pfam13936 266264013328 Integrase core domain; Region: rve; pfam00665 266264013329 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 266264013330 Protein of unknown function (DUF1311); Region: DUF1311; pfam07007 266264013331 Membrane-bound lysozyme-inhibitor of c-type lysozyme; Region: MliC; pfam09864 266264013332 Predicted enzyme of the cupin superfamily [General function prediction only]; Region: COG3450 266264013333 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 266264013334 oligomeric interface; other site 266264013335 putative active site [active] 266264013336 homodimer interface [polypeptide binding]; other site 266264013337 shikimate kinase; Reviewed; Region: aroK; PRK00131 266264013338 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 266264013339 ADP binding site [chemical binding]; other site 266264013340 magnesium binding site [ion binding]; other site 266264013341 putative shikimate binding site; other site 266264013342 benzoate transport; Region: 2A0115; TIGR00895 266264013343 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266264013344 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266264013345 pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424 266264013346 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266264013347 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 266264013348 dimerization interface [polypeptide binding]; other site 266264013349 Protocatechuate 3,4-dioxygenase (3,4-PCD) , beta subunit. 3,4-PCD catalyzes the oxidative ring cleavage of 3,4-dihydroxybenzoate to produce beta-carboxy-cis,cis-muconate. 3,4-PCDs are large aggregates of 12 protomers, each composed of an alpha- and...; Region: 3,4-PCD_beta; cd03464 266264013350 multimer interface [polypeptide binding]; other site 266264013351 heterodimer interface [polypeptide binding]; other site 266264013352 protocatechuate 3,4-dioxygenase, beta subunit; Region: protocat_beta; TIGR02422 266264013353 active site 266264013354 Protocatechuate 3,4-dioxygenase (3,4-PCD) , alpha subunit. 3,4-PCD catalyzes the oxidative ring cleavage of 3,4-dihydroxybenzoate to produce beta-carboxy-cis,cis-muconate. 3,4-PCDs are large aggregates of 12 protomers, each composed of an alpha- and...; Region: 3,4-PCD_alpha; cd03463 266264013355 heterodimer interface [polypeptide binding]; other site 266264013356 Protocatechuate 3,4-dioxygenase beta subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PcaH; COG3485 266264013357 active site 266264013358 3-carboxy-cis,cis-muconate cycloisomerase; Provisional; Region: PRK09053 266264013359 prokaryotic 3-carboxy-cis,cis-muconate cycloisomerase (CMLE)_like; Region: pCLME; cd01597 266264013360 tetramer interface [polypeptide binding]; other site 266264013361 active site 266264013362 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 266264013363 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 266264013364 4-carboxymuconolactone decarboxylase; Region: decarb_PcaC; TIGR02425 266264013365 4-hydroxyphenylacetate catabolism regulatory protein HpaA; Region: HpaA; TIGR02297 266264013366 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 266264013367 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 266264013368 Regulatory phage protein cox; Region: Phage_Cox; pfam10743 266264013369 4-hydroxybenzoate 3-monooxygenase; Validated; Region: PRK08243 266264013370 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 266264013371 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 266264013372 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 266264013373 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 266264013374 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266264013375 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266264013376 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_3; cd08461 266264013377 putative substrate binding pocket [chemical binding]; other site 266264013378 putative dimerization interface [polypeptide binding]; other site 266264013379 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 266264013380 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266264013381 putative substrate translocation pore; other site 266264013382 Uncharacterized protein conserved in bacteria (DUF2076); Region: DUF2076; pfam09849 266264013383 proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249 266264013384 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: COG3264 266264013385 Protein of unknown function (DUF3772); Region: DUF3772; pfam12607 266264013386 Mechanosensitive ion channel; Region: MS_channel; pfam00924 266264013387 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_2; cd07253 266264013388 dimer interface [polypeptide binding]; other site 266264013389 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 266264013390 metal binding site [ion binding]; metal-binding site 266264013391 Cytochrome c2 [Energy production and conversion]; Region: COG3474 266264013392 putative heme-binding domain, Pirellula/Verrucomicrobium type; Region: CxxCH_TIGR02603 266264013393 hypothetical protein; Provisional; Region: PRK02237 266264013394 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266264013395 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266264013396 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 266264013397 dimerization interface [polypeptide binding]; other site 266264013398 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 266264013399 PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as bacitracin transport permeases, as it was suspected that they form the permease component of an ABC transporter system. It was shown, however, that BcrC from...; Region: PAP2_BcrC_like; cd03385 266264013400 active site 266264013401 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 266264013402 Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4705 266264013403 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 266264013404 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 266264013405 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 266264013406 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 266264013407 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 266264013408 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 266264013409 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 266264013410 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 266264013411 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266264013412 active site 266264013413 phosphorylation site [posttranslational modification] 266264013414 intermolecular recognition site; other site 266264013415 dimerization interface [polypeptide binding]; other site 266264013416 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 266264013417 DNA binding site [nucleotide binding] 266264013418 sensor protein QseC; Provisional; Region: PRK10337 266264013419 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 266264013420 dimer interface [polypeptide binding]; other site 266264013421 phosphorylation site [posttranslational modification] 266264013422 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266264013423 ATP binding site [chemical binding]; other site 266264013424 Mg2+ binding site [ion binding]; other site 266264013425 G-X-G motif; other site 266264013426 Predicted membrane protein [Function unknown]; Region: COG2510 266264013427 multiple promoter invertase; Provisional; Region: mpi; PRK13413 266264013428 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 266264013429 catalytic residues [active] 266264013430 catalytic nucleophile [active] 266264013431 Presynaptic Site I dimer interface [polypeptide binding]; other site 266264013432 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 266264013433 Synaptic Flat tetramer interface [polypeptide binding]; other site 266264013434 Synaptic Site I dimer interface [polypeptide binding]; other site 266264013435 DNA binding site [nucleotide binding] 266264013436 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 266264013437 DNA-binding interface [nucleotide binding]; DNA binding site 266264013438 TniQ; Region: TniQ; pfam06527 266264013439 Bacterial TniB protein; Region: TniB; pfam05621 266264013440 Integrase core domain; Region: rve; pfam00665 266264013441 Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299 266264013442 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 266264013443 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 266264013444 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 266264013445 GAF domain; Region: GAF_2; pfam13185 266264013446 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 266264013447 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 266264013448 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 266264013449 GST_N family, unknown subfamily 4; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_4; cd03056 266264013450 putative C-terminal domain interface [polypeptide binding]; other site 266264013451 putative GSH binding site (G-site) [chemical binding]; other site 266264013452 putative dimer interface [polypeptide binding]; other site 266264013453 C-terminal, alpha helical domain of an unknown subfamily 7 of Glutathione S-transferases; Region: GST_C_7; cd03206 266264013454 putative N-terminal domain interface [polypeptide binding]; other site 266264013455 putative dimer interface [polypeptide binding]; other site 266264013456 putative substrate binding pocket (H-site) [chemical binding]; other site 266264013457 transcriptional regulator; Provisional; Region: PRK10632 266264013458 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_2; cd08471 266264013459 putative effector binding pocket; other site 266264013460 putative dimerization interface [polypeptide binding]; other site 266264013461 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 266264013462 Domain of unknown function DUF20; Region: UPF0118; pfam01594 266264013463 Cytochrome C biogenesis protein; Region: CcmH; pfam03918 266264013464 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: COG4235 266264013465 periplasmic protein thiol:disulfide oxidoreductases, DsbE subfamily; Region: dsbE; TIGR00385 266264013466 TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010 266264013467 catalytic residues [active] 266264013468 central insert; other site 266264013469 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: CcmF; COG1138 266264013470 cytochrome c-type biogenesis protein CcmE; Reviewed; Region: PRK13254 266264013471 Heme exporter protein D (CcmD); Region: CcmD; cl11475 266264013472 heme exporter protein CcmC; Region: ccmC; TIGR01191 266264013473 ABC-type transport system involved in cytochrome c biogenesis, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CcmB; COG2386 266264013474 cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13538 266264013475 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 266264013476 Walker A/P-loop; other site 266264013477 ATP binding site [chemical binding]; other site 266264013478 Q-loop/lid; other site 266264013479 ABC transporter signature motif; other site 266264013480 Walker B; other site 266264013481 D-loop; other site 266264013482 H-loop/switch region; other site 266264013483 periplasmic nitrate (or nitrite) reductase c-type cytochrome, NapC/NirT family; Region: napC_nirT; TIGR02161 266264013484 NapC/NirT cytochrome c family, N-terminal region; Region: Cytochrom_NNT; pfam03264 266264013485 Nitrate reductase cytochrome c-type subunit (NapB); Region: NapB; pfam03892 266264013486 nitrate reductase catalytic subunit; Provisional; Region: PRK13532 266264013487 Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409 266264013488 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 266264013489 [4Fe-4S] binding site [ion binding]; other site 266264013490 molybdopterin cofactor binding site; other site 266264013491 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 266264013492 molybdopterin cofactor binding site; other site 266264013493 NapD protein; Region: NapD; pfam03927 266264013494 Periplasmic nitrate reductase protein NapE; Region: NapE; pfam06796 266264013495 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 266264013496 acyl-CoA synthetase; Validated; Region: PRK06178 266264013497 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 266264013498 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 266264013499 acyl-activating enzyme (AAE) consensus motif; other site 266264013500 AMP binding site [chemical binding]; other site 266264013501 active site 266264013502 CoA binding site [chemical binding]; other site 266264013503 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 266264013504 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 266264013505 ATP-grasp domain; Region: ATP-grasp_4; cl17255 266264013506 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785 266264013507 Biotin carboxyl carrier protein [Lipid metabolism]; Region: AccB; COG0511 266264013508 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 266264013509 carboxyltransferase (CT) interaction site; other site 266264013510 biotinylation site [posttranslational modification]; other site 266264013511 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 266264013512 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 266264013513 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 266264013514 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 266264013515 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266264013516 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 266264013517 dimerization interface [polypeptide binding]; other site 266264013518 substrate binding pocket [chemical binding]; other site 266264013519 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 266264013520 CoA-transferase family III; Region: CoA_transf_3; pfam02515 266264013521 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 266264013522 active site 266264013523 catalytic site [active] 266264013524 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 266264013525 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 266264013526 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 266264013527 active site 266264013528 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 266264013529 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 266264013530 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 266264013531 classical (c) SDRs; Region: SDR_c; cd05233 266264013532 NAD(P) binding site [chemical binding]; other site 266264013533 active site 266264013534 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 266264013535 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 266264013536 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266264013537 putative substrate translocation pore; other site 266264013538 conserved hypothetical protein, partial overlap 266264013539 potential protein location (conserved hypothetical protein) that overlaps protein (hypothetical protein) 266264013540 GYD domain; Region: GYD; pfam08734 266264013541 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 266264013542 dimer interface [polypeptide binding]; other site 266264013543 Alkaline phosphatase homologues; Region: alkPPc; smart00098 266264013544 active site 266264013545 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 266264013546 dimer interface [polypeptide binding]; other site 266264013547 Alkaline phosphatase homologues; Region: alkPPc; smart00098 266264013548 active site 266264013549 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3009 266264013550 Protein of unknown function (DUF330); Region: DUF330; pfam03886 266264013551 Paraquat-inducible protein B [General function prediction only]; Region: PqiB; COG3008 266264013552 mce related protein; Region: MCE; pfam02470 266264013553 mce related protein; Region: MCE; pfam02470 266264013554 mce related protein; Region: MCE; pfam02470 266264013555 Uncharacterized paraquat-inducible protein A [Function unknown]; Region: PqiA; COG2995 266264013556 Paraquat-inducible protein A; Region: PqiA; pfam04403 266264013557 Paraquat-inducible protein A; Region: PqiA; pfam04403 266264013558 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 266264013559 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 266264013560 DNA binding residues [nucleotide binding] 266264013561 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 266264013562 Old yellow enzyme (OYE)-related FMN binding domain, group 2. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_2_FMN; cd04733 266264013563 putative active site [active] 266264013564 putative FMN binding site [chemical binding]; other site 266264013565 putative substrate binding site [chemical binding]; other site 266264013566 putative catalytic residue [active] 266264013567 LysR family transcriptional regulator; Provisional; Region: PRK14997 266264013568 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266264013569 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_4; cd08473 266264013570 putative effector binding pocket; other site 266264013571 putative dimerization interface [polypeptide binding]; other site 266264013572 Pirin-related protein [General function prediction only]; Region: COG1741 266264013573 Pirin; Region: Pirin; pfam02678 266264013574 Predicted membrane protein [Function unknown]; Region: COG2259 266264013575 SnoaL-like domain; Region: SnoaL_2; pfam12680 266264013576 NAD(P)H:quinone oxidoreductase; Provisional; Region: PRK03767 266264013577 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 266264013578 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 266264013579 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 266264013580 trimer interface [polypeptide binding]; other site 266264013581 eyelet of channel; other site 266264013582 Protein of unknown function (DUF1275); Region: DUF1275; pfam06912 266264013583 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 266264013584 CoA-transferase family III; Region: CoA_transf_3; pfam02515 266264013585 Transcriptional regulators [Transcription]; Region: GntR; COG1802 266264013586 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266264013587 DNA-binding site [nucleotide binding]; DNA binding site 266264013588 FCD domain; Region: FCD; pfam07729 266264013589 enoyl-CoA hydratase; Provisional; Region: PRK06144 266264013590 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 266264013591 substrate binding site [chemical binding]; other site 266264013592 oxyanion hole (OAH) forming residues; other site 266264013593 trimer interface [polypeptide binding]; other site 266264013594 ABC-type phosphate/phosphonate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PhnD; COG3221 266264013595 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 266264013596 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 266264013597 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 266264013598 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 266264013599 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 266264013600 FMN binding site [chemical binding]; other site 266264013601 active site 266264013602 substrate binding site [chemical binding]; other site 266264013603 catalytic residue [active] 266264013604 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 266264013605 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 266264013606 Walker A motif; other site 266264013607 ATP binding site [chemical binding]; other site 266264013608 Walker B motif; other site 266264013609 arginine finger; other site 266264013610 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 266264013611 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 266264013612 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 266264013613 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 266264013614 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 266264013615 Hydantoinase B/oxoprolinase; Region: Hydantoinase_B; pfam02538 266264013616 Acetone carboxylase, gamma subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcxC; COG4647 266264013617 Acetone carboxylase gamma subunit; Region: Acetone_carb_G; pfam08882 266264013618 class II aldolase/adducin domain protein; Provisional; Region: PRK07090 266264013619 intersubunit interface [polypeptide binding]; other site 266264013620 active site 266264013621 Zn2+ binding site [ion binding]; other site 266264013622 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 266264013623 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 266264013624 non-specific DNA binding site [nucleotide binding]; other site 266264013625 salt bridge; other site 266264013626 sequence-specific DNA binding site [nucleotide binding]; other site 266264013627 Cupin domain; Region: Cupin_2; pfam07883 266264013628 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 266264013629 MOSC domain; Region: MOSC; pfam03473 266264013630 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 266264013631 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 266264013632 FMN-binding pocket [chemical binding]; other site 266264013633 flavin binding motif; other site 266264013634 phosphate binding motif [ion binding]; other site 266264013635 beta-alpha-beta structure motif; other site 266264013636 NAD binding pocket [chemical binding]; other site 266264013637 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 266264013638 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 266264013639 catalytic residue [active] 266264013640 pyridoxamine kinase; Validated; Region: PRK05756 266264013641 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 266264013642 dimer interface [polypeptide binding]; other site 266264013643 pyridoxal binding site [chemical binding]; other site 266264013644 ATP binding site [chemical binding]; other site 266264013645 phosphatidylserine decarboxylase; Reviewed; Region: psd; PRK00044 266264013646 hypothetical protein 266264013647 transcriptional regulatory protein PtsJ; Provisional; Region: PRK15481 266264013648 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266264013649 DNA-binding site [nucleotide binding]; DNA binding site 266264013650 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 266264013651 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266264013652 homodimer interface [polypeptide binding]; other site 266264013653 catalytic residue [active] 266264013654 Outer membrane efflux protein; Region: OEP; pfam02321 266264013655 Outer membrane efflux protein; Region: OEP; pfam02321 266264013656 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 266264013657 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 266264013658 HlyD family secretion protein; Region: HlyD_3; pfam13437 266264013659 Helix-turn-helix domain; Region: HTH_38; pfam13936 266264013660 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 266264013661 Integrase core domain; Region: rve; pfam00665 266264013662 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 266264013663 Protein of unknown function (DUF2880); Region: DUF2880; pfam11082 266264013664 Protein of unknown function (DUF1579); Region: DUF1579; pfam07617 266264013665 NifQ; Region: NifQ; pfam04891 266264013666 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 266264013667 non-specific DNA interactions [nucleotide binding]; other site 266264013668 DNA binding site [nucleotide binding] 266264013669 sequence specific DNA binding site [nucleotide binding]; other site 266264013670 putative cAMP binding site [chemical binding]; other site 266264013671 DNA Polymerase Y-family; Region: PolY_like; cd03468 266264013672 active site 266264013673 DNA binding site [nucleotide binding] 266264013674 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 266264013675 active site 266264013676 error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672 266264013677 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at DnaE2 gene; Region: PHP_PolIIIA_DnaE2; cd07434 266264013678 putative PHP Thumb interface [polypeptide binding]; other site 266264013679 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 266264013680 generic binding surface II; other site 266264013681 generic binding surface I; other site 266264013682 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 266264013683 Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by...; Region: PRX_1cys; cd03016 266264013684 dimer interface [polypeptide binding]; other site 266264013685 decamer (pentamer of dimers) interface [polypeptide binding]; other site 266264013686 catalytic triad [active] 266264013687 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 266264013688 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 266264013689 E3 interaction surface; other site 266264013690 lipoyl attachment site [posttranslational modification]; other site 266264013691 e3 binding domain; Region: E3_binding; pfam02817 266264013692 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 266264013693 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 266264013694 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 266264013695 alpha subunit interface [polypeptide binding]; other site 266264013696 TPP binding site [chemical binding]; other site 266264013697 heterodimer interface [polypeptide binding]; other site 266264013698 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 266264013699 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 266264013700 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 266264013701 tetramer interface [polypeptide binding]; other site 266264013702 TPP-binding site [chemical binding]; other site 266264013703 heterodimer interface [polypeptide binding]; other site 266264013704 phosphorylation loop region [posttranslational modification] 266264013705 Protein of unknown function (DUF2886); Region: DUF2886; pfam11102 266264013706 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 266264013707 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 266264013708 active site 266264013709 iron coordination sites [ion binding]; other site 266264013710 substrate binding pocket [chemical binding]; other site 266264013711 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 266264013712 NMT1-like family; Region: NMT1_2; pfam13379 266264013713 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 266264013714 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 266264013715 Walker A/P-loop; other site 266264013716 ATP binding site [chemical binding]; other site 266264013717 Q-loop/lid; other site 266264013718 ABC transporter signature motif; other site 266264013719 Walker B; other site 266264013720 D-loop; other site 266264013721 H-loop/switch region; other site 266264013722 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 266264013723 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266264013724 putative PBP binding loops; other site 266264013725 dimer interface [polypeptide binding]; other site 266264013726 ABC-ATPase subunit interface; other site 266264013727 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 266264013728 S-adenosylmethionine binding site [chemical binding]; other site 266264013729 major facilitator superfamily transporter; Provisional; Region: PRK05122 266264013730 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266264013731 putative substrate translocation pore; other site 266264013732 Transcriptional regulator [Transcription]; Region: IclR; COG1414 266264013733 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 266264013734 Bacterial transcriptional regulator; Region: IclR; pfam01614 266264013735 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 266264013736 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 266264013737 metal binding site [ion binding]; metal-binding site 266264013738 active site 266264013739 I-site; other site 266264013740 Citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CCL cleaves citryl-CoA (CiCoA) to acetyl-CoA (AcCoA) and oxaloacetate (OAA); Region: CCL_ACL-C; cd06100 266264013741 active site 266264013742 oxalacetate binding site [chemical binding]; other site 266264013743 citrylCoA binding site [chemical binding]; other site 266264013744 coenzyme A binding site [chemical binding]; other site 266264013745 catalytic triad [active] 266264013746 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 266264013747 CoA-transferase family III; Region: CoA_transf_3; pfam02515 266264013748 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 266264013749 hypothetical protein; Provisional; Region: PRK07077 266264013750 squalene-hopene cyclase; Region: hopene_cyclase; TIGR01507 266264013751 Squalene cyclase (SQCY) domain subgroup 1; found in class II terpene cyclases that have an alpha 6 - alpha 6 barrel fold. Squalene cyclase (SQCY) and 2,3-oxidosqualene cyclase (OSQCY) are integral membrane proteins that catalyze a cationic cyclization...; Region: SQCY_1; cd02892 266264013752 Active site cavity [active] 266264013753 catalytic acid [active] 266264013754 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 266264013755 active site lid residues [active] 266264013756 substrate binding pocket [chemical binding]; other site 266264013757 catalytic residues [active] 266264013758 substrate-Mg2+ binding site; other site 266264013759 aspartate-rich region 1; other site 266264013760 aspartate-rich region 2; other site 266264013761 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 266264013762 DNA-binding site [nucleotide binding]; DNA binding site 266264013763 RNA-binding motif; other site 266264013764 Winged helix-turn helix; Region: HTH_29; pfam13551 266264013765 Integrase core domain; Region: rve; pfam00665 266264013766 DDE domain; Region: DDE_Tnp_IS240; pfam13610 266264013767 Integrase core domain; Region: rve_3; pfam13683 266264013768 Transposase domain (DUF772); Region: DUF772; pfam05598 266264013769 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 266264013770 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 266264013771 Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006 266264013772 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 266264013773 Uncharacterized conserved protein [Function unknown]; Region: COG3868 266264013774 C-terminal Putative NodB-like catalytic domain of PelA-like uncharacterized hypothetical proteins found in bacteria; Region: CE4_PelA_like_C; cd10922 266264013775 putative active site [active] 266264013776 Tetratricopeptide repeat; Region: TPR_15; pfam13429 266264013777 Predicted integral membrane protein [Function unknown]; Region: COG5616 266264013778 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 266264013779 GAF domain; Region: GAF_3; pfam13492 266264013780 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_3; cd03813 266264013781 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 266264013782 Predicted membrane protein [Function unknown]; Region: COG4267 266264013783 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 266264013784 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266264013785 active site 266264013786 phosphorylation site [posttranslational modification] 266264013787 intermolecular recognition site; other site 266264013788 dimerization interface [polypeptide binding]; other site 266264013789 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 266264013790 DNA binding site [nucleotide binding] 266264013791 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4254 266264013792 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 266264013793 FecR protein; Region: FecR; pfam04773 266264013794 Predicted transmembrane sensor domain [Signal transduction mechanisms]; Region: COG4252 266264013795 CHASE2 domain; Region: CHASE2; pfam05226 266264013796 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 266264013797 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 266264013798 dimer interface [polypeptide binding]; other site 266264013799 phosphorylation site [posttranslational modification] 266264013800 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266264013801 ATP binding site [chemical binding]; other site 266264013802 Mg2+ binding site [ion binding]; other site 266264013803 G-X-G motif; other site 266264013804 VacJ like lipoprotein; Region: VacJ; cl01073 266264013805 hopanoid biosynthesis associated RND transporter like protein HpnN; Region: HpnN; TIGR03480 266264013806 Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; pfam05494 266264013807 hopanoid biosynthesis associated radical SAM protein HpnH; Region: HpnH; TIGR03470 266264013808 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 266264013809 FeS/SAM binding site; other site 266264013810 Domain of unknown function (DUF3463); Region: DUF3463; pfam11946 266264013811 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 266264013812 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 266264013813 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466 266264013814 uncharacterized subgroup of aldehyde reductase and flavonoid reductase related proteins, extended (e) SDRs; Region: AR_FR_like_1_SDR_e; cd05228 266264013815 putative NADP binding site [chemical binding]; other site 266264013816 putative substrate binding site [chemical binding]; other site 266264013817 active site 266264013818 hopene-associated glycosyltransferase HpnB; Region: HpnB; TIGR03469 266264013819 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 266264013820 active site 266264013821 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183 266264013822 dimerization interface [polypeptide binding]; other site 266264013823 putative active cleft [active] 266264013824 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266264013825 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266264013826 LysR substrate binding domain; Region: LysR_substrate; pfam03466 266264013827 dimerization interface [polypeptide binding]; other site 266264013828 putative transporter; Provisional; Region: PRK10504 266264013829 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266264013830 putative substrate translocation pore; other site 266264013831 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266264013832 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 266264013833 dimerization interface [polypeptide binding]; other site 266264013834 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 266264013835 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 266264013836 active site 1 [active] 266264013837 dimer interface [polypeptide binding]; other site 266264013838 hexamer interface [polypeptide binding]; other site 266264013839 active site 2 [active] 266264013840 Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230 266264013841 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 266264013842 dimer interface [polypeptide binding]; other site 266264013843 putative CheW interface [polypeptide binding]; other site 266264013844 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 266264013845 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 266264013846 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 266264013847 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 266264013848 Peptidase M14-like domain; uncharacterized subfamily; Region: M14-like_7; cd03862 266264013849 putative active site [active] 266264013850 Zn binding site [ion binding]; other site 266264013851 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266264013852 aminoethylphosphonate catabolism associated LysR family transcriptional regulator; Region: phn_lysR; TIGR03339 266264013853 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 266264013854 dimerization interface [polypeptide binding]; other site 266264013855 phospholipase C, phosphocholine-specific, Pseudomonas-type; Region: PC_PLC; TIGR03396 266264013856 Phosphoesterase family; Region: Phosphoesterase; pfam04185 266264013857 Domain of unknown function (DUF756); Region: DUF756; pfam05506 266264013858 Domain of unknown function (DUF756); Region: DUF756; pfam05506 266264013859 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Low Specificity D-Threonine Aldolase; Region: PLPDE_III_LS_D-TA; cd06819 266264013860 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 266264013861 dimer interface [polypeptide binding]; other site 266264013862 active site 266264013863 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 266264013864 substrate binding site [chemical binding]; other site 266264013865 catalytic residue [active] 266264013866 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 266264013867 dimerization interface [polypeptide binding]; other site 266264013868 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 266264013869 dimer interface [polypeptide binding]; other site 266264013870 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 266264013871 putative CheW interface [polypeptide binding]; other site 266264013872 2-hydroxychromene-2-carboxylate isomerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NahD; COG3917 266264013873 DsbA family, 2-hydroxychromene-2-carboxylate (HCCA) isomerase subfamily; HCCA isomerase is a glutathione (GSH) dependent enzyme involved in the naphthalene catabolic pathway. It converts HCCA, a hemiketal formed spontaneously after ring cleavage of 1; Region: DsbA_HCCA_Iso; cd03022 266264013874 putative catalytic residue [active] 266264013875 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 266264013876 classical (c) SDR, subgroup 10; Region: SDR_c10; cd05373 266264013877 putative NAD(P) binding site [chemical binding]; other site 266264013878 active site 266264013879 Predicted transcriptional regulators [Transcription]; Region: COG1695 266264013880 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 266264013881 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 266264013882 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 266264013883 FAD binding pocket [chemical binding]; other site 266264013884 FAD binding motif [chemical binding]; other site 266264013885 phosphate binding motif [ion binding]; other site 266264013886 NAD binding pocket [chemical binding]; other site 266264013887 aminotransferase; Validated; Region: PRK08175 266264013888 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 266264013889 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266264013890 homodimer interface [polypeptide binding]; other site 266264013891 catalytic residue [active] 266264013892 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 266264013893 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266264013894 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 266264013895 dimerization interface [polypeptide binding]; other site 266264013896 substrate binding pocket [chemical binding]; other site 266264013897 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 266264013898 Uncharacterized proteins, LmbE homologs [Function unknown]; Region: COG2120 266264013899 hypothetical protein; Provisional; Region: PRK09262 266264013900 nitrogen assimilation transcriptional regulator; Provisional; Region: PRK11233 266264013901 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266264013902 The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433 266264013903 putative dimerization interface [polypeptide binding]; other site 266264013904 Helix-turn-helix domain; Region: HTH_38; pfam13936 266264013905 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 266264013906 Integrase core domain; Region: rve; pfam00665 266264013907 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 266264013908 putative active site [active] 266264013909 tricarballylate dehydrogenase; Validated; Region: PRK08274 266264013910 tricarballylate utilization protein B; Provisional; Region: PRK15033 266264013911 aldolase II superfamily protein; Provisional; Region: PRK07044 266264013912 intersubunit interface [polypeptide binding]; other site 266264013913 active site 266264013914 Zn2+ binding site [ion binding]; other site 266264013915 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 266264013916 Putative D-isomer specific 2-hydroxyacid dehydrogenase; Region: 2-Hacid_dh_1; cd05300 266264013917 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 266264013918 NAD binding site [chemical binding]; other site 266264013919 ligand binding site [chemical binding]; other site 266264013920 catalytic site [active] 266264013921 Response regulator receiver domain; Region: Response_reg; pfam00072 266264013922 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266264013923 active site 266264013924 phosphorylation site [posttranslational modification] 266264013925 intermolecular recognition site; other site 266264013926 dimerization interface [polypeptide binding]; other site 266264013927 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 266264013928 E3 interaction surface; other site 266264013929 lipoyl attachment site [posttranslational modification]; other site 266264013930 dihydrolipoamide dehydrogenase; Validated; Region: PRK06327 266264013931 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 266264013932 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 266264013933 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 266264013934 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 266264013935 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266264013936 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 266264013937 dimerization interface [polypeptide binding]; other site 266264013938 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 266264013939 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 266264013940 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 266264013941 trimer interface [polypeptide binding]; other site 266264013942 eyelet of channel; other site 266264013943 Transcriptional regulator [Transcription]; Region: IclR; COG1414 266264013944 IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339 266264013945 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 266264013946 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 266264013947 CoA-transferase family III; Region: CoA_transf_3; pfam02515 266264013948 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 266264013949 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 266264013950 substrate binding site [chemical binding]; other site 266264013951 oxyanion hole (OAH) forming residues; other site 266264013952 trimer interface [polypeptide binding]; other site 266264013953 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266264013954 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266264013955 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 266264013956 putative dimerization interface [polypeptide binding]; other site 266264013957 Transposase domain (DUF772); Region: DUF772; pfam05598 266264013958 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 266264013959 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 266264013960 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 266264013961 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266264013962 active site 266264013963 phosphorylation site [posttranslational modification] 266264013964 intermolecular recognition site; other site 266264013965 dimerization interface [polypeptide binding]; other site 266264013966 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 266264013967 DNA binding residues [nucleotide binding] 266264013968 dimerization interface [polypeptide binding]; other site 266264013969 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 266264013970 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 266264013971 trimer interface [polypeptide binding]; other site 266264013972 eyelet of channel; other site 266264013973 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 266264013974 hypothetical protein; Validated; Region: PRK06201 266264013975 Demethylmenaquinone methyltransferase [Coenzyme metabolism]; Region: MenG; COG0684 266264013976 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 266264013977 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 266264013978 ligand binding site [chemical binding]; other site 266264013979 NAD binding site [chemical binding]; other site 266264013980 dimerization interface [polypeptide binding]; other site 266264013981 catalytic site [active] 266264013982 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 266264013983 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266264013984 active site 266264013985 phosphorylation site [posttranslational modification] 266264013986 intermolecular recognition site; other site 266264013987 dimerization interface [polypeptide binding]; other site 266264013988 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 266264013989 DNA binding residues [nucleotide binding] 266264013990 dimerization interface [polypeptide binding]; other site 266264013991 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 266264013992 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 266264013993 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 266264013994 eyelet of channel; other site 266264013995 trimer interface [polypeptide binding]; other site 266264013996 aconitate hydratase; Validated; Region: PRK09277 266264013997 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 266264013998 substrate binding site [chemical binding]; other site 266264013999 ligand binding site [chemical binding]; other site 266264014000 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 266264014001 substrate binding site [chemical binding]; other site 266264014002 Serine hydrolase; Region: Ser_hydrolase; cl17834 266264014003 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 266264014004 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 266264014005 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 266264014006 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 266264014007 ligand binding site [chemical binding]; other site 266264014008 flexible hinge region; other site 266264014009 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 266264014010 putative switch regulator; other site 266264014011 non-specific DNA interactions [nucleotide binding]; other site 266264014012 DNA binding site [nucleotide binding] 266264014013 sequence specific DNA binding site [nucleotide binding]; other site 266264014014 putative cAMP binding site [chemical binding]; other site 266264014015 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266264014016 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266264014017 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 266264014018 putative dimerization interface [polypeptide binding]; other site 266264014019 Protein of unknown function (DUF1311); Region: DUF1311; pfam07007 266264014020 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 266264014021 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 266264014022 putative chaperone protein EcpD; Provisional; Region: PRK09926 266264014023 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 266264014024 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 266264014025 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 266264014026 PapC N-terminal domain; Region: PapC_N; pfam13954 266264014027 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 266264014028 PapC C-terminal domain; Region: PapC_C; pfam13953 266264014029 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 266264014030 HAMP domain; Region: HAMP; pfam00672 266264014031 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 266264014032 dimer interface [polypeptide binding]; other site 266264014033 phosphorylation site [posttranslational modification] 266264014034 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266264014035 ATP binding site [chemical binding]; other site 266264014036 Mg2+ binding site [ion binding]; other site 266264014037 G-X-G motif; other site 266264014038 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 266264014039 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 266264014040 substrate binding pocket [chemical binding]; other site 266264014041 membrane-bound complex binding site; other site 266264014042 hinge residues; other site 266264014043 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 266264014044 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 266264014045 substrate binding pocket [chemical binding]; other site 266264014046 membrane-bound complex binding site; other site 266264014047 hinge residues; other site 266264014048 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 266264014049 PAS domain; Region: PAS_9; pfam13426 266264014050 putative active site [active] 266264014051 heme pocket [chemical binding]; other site 266264014052 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 266264014053 dimer interface [polypeptide binding]; other site 266264014054 phosphorylation site [posttranslational modification] 266264014055 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266264014056 ATP binding site [chemical binding]; other site 266264014057 Mg2+ binding site [ion binding]; other site 266264014058 G-X-G motif; other site 266264014059 Response regulator receiver domain; Region: Response_reg; pfam00072 266264014060 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266264014061 active site 266264014062 phosphorylation site [posttranslational modification] 266264014063 intermolecular recognition site; other site 266264014064 dimerization interface [polypeptide binding]; other site 266264014065 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 266264014066 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266264014067 voltage-gated potassium channel; Provisional; Region: PRK10537 266264014068 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 266264014069 Pirin-related protein [General function prediction only]; Region: COG1741 266264014070 Pirin; Region: Pirin; pfam02678 266264014071 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 266264014072 LysR family transcriptional regulator; Provisional; Region: PRK14997 266264014073 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266264014074 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_4; cd08473 266264014075 putative effector binding pocket; other site 266264014076 putative dimerization interface [polypeptide binding]; other site 266264014077 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266264014078 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266264014079 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 266264014080 putative effector binding pocket; other site 266264014081 dimerization interface [polypeptide binding]; other site 266264014082 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 266264014083 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 266264014084 dimer interface [polypeptide binding]; other site 266264014085 TPP-binding site [chemical binding]; other site 266264014086 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 266264014087 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 266264014088 AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246 266264014089 Uncharacterized conserved protein [Function unknown]; Region: COG1359 266264014090 Isochorismatase family; Region: Isochorismatase; pfam00857 266264014091 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 266264014092 catalytic triad [active] 266264014093 dimer interface [polypeptide binding]; other site 266264014094 conserved cis-peptide bond; other site 266264014095 Citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CCL cleaves citryl-CoA (CiCoA) to acetyl-CoA (AcCoA) and oxaloacetate (OAA); Region: CCL_ACL-C; cd06100 266264014096 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 266264014097 active site 266264014098 oxalacetate binding site [chemical binding]; other site 266264014099 citrylCoA binding site [chemical binding]; other site 266264014100 coenzyme A binding site [chemical binding]; other site 266264014101 catalytic triad [active] 266264014102 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 266264014103 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 266264014104 acyl-activating enzyme (AAE) consensus motif; other site 266264014105 AMP binding site [chemical binding]; other site 266264014106 active site 266264014107 CoA binding site [chemical binding]; other site 266264014108 Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl17208 266264014109 chlorocatechol 1,2-dioxygenase; Region: chlorocat_1_2; TIGR02465 266264014110 active site 266264014111 beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431 266264014112 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 266264014113 Bacterial transcriptional regulator; Region: IclR; pfam01614 266264014114 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 266264014115 CoA-transferase family III; Region: CoA_transf_3; pfam02515 266264014116 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 266264014117 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 266264014118 substrate binding site [chemical binding]; other site 266264014119 ligand binding site [chemical binding]; other site 266264014120 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 266264014121 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 266264014122 substrate binding site [chemical binding]; other site 266264014123 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 266264014124 HlyD family secretion protein; Region: HlyD; pfam00529 266264014125 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 266264014126 HlyD family secretion protein; Region: HlyD_3; pfam13437 266264014127 Protein of unknown function (DUF1656); Region: DUF1656; pfam07869 266264014128 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 266264014129 Fusaric acid resistance protein family; Region: FUSC; pfam04632 266264014130 OHCU decarboxylase; Region: OHCU_decarbox; cl01251 266264014131 Predicted membrane protein [Function unknown]; Region: COG2259 266264014132 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 266264014133 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 266264014134 NAD(P) binding site [chemical binding]; other site 266264014135 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266264014136 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266264014137 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 266264014138 dimerization interface [polypeptide binding]; other site 266264014139 BON domain; Region: BON; pfam04972 266264014140 Predicted small secreted protein [Function unknown]; Region: COG5510 266264014141 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_5; cd07238 266264014142 dimer interface [polypeptide binding]; other site 266264014143 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 266264014144 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 266264014145 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 266264014146 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 266264014147 short chain dehydrogenase; Validated; Region: PRK06182 266264014148 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 266264014149 NADP binding site [chemical binding]; other site 266264014150 active site 266264014151 steroid binding site; other site 266264014152 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266264014153 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 266264014154 NAD(P) binding site [chemical binding]; other site 266264014155 active site 266264014156 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 266264014157 Helix-turn-helix domain; Region: HTH_18; pfam12833 266264014158 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 266264014159 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 266264014160 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 266264014161 tetramer interface [polypeptide binding]; other site 266264014162 active site 266264014163 Mg2+/Mn2+ binding site [ion binding]; other site 266264014164 Propionate catabolism activator; Region: PrpR_N; pfam06506 266264014165 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 266264014166 PAS domain; Region: PAS; smart00091 266264014167 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 266264014168 Walker A motif; other site 266264014169 ATP binding site [chemical binding]; other site 266264014170 Walker B motif; other site 266264014171 arginine finger; other site 266264014172 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 266264014173 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 266264014174 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 266264014175 putative NAD(P) binding site [chemical binding]; other site 266264014176 SnoaL-like domain; Region: SnoaL_2; pfam12680 266264014177 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266264014178 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266264014179 LysR substrate binding domain; Region: LysR_substrate; pfam03466 266264014180 dimerization interface [polypeptide binding]; other site 266264014181 C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663 266264014182 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 266264014183 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 266264014184 SLBB domain; Region: SLBB; pfam10531 266264014185 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 266264014186 L-aspartate oxidase; Provisional; Region: PRK06175 266264014187 FAD binding domain; Region: FAD_binding_2; pfam00890 266264014188 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 266264014189 catalytic loop [active] 266264014190 iron binding site [ion binding]; other site 266264014191 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 266264014192 4Fe-4S dicluster domain; Region: Fer4_17; pfam13534 266264014193 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 266264014194 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 266264014195 transmembrane helices; other site 266264014196 hypothetical protein 266264014197 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266264014198 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 266264014199 putative substrate translocation pore; other site 266264014200 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 266264014201 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 266264014202 Adenylation domain of proteins similar to ATP-dependent polynucleotide ligases; Region: Adenylation_DNA_ligase_like; cl12015 266264014203 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 266264014204 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 266264014205 hypothetical protein 266264014206 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 266264014207 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 266264014208 oxidoreductase protein (fragment) 266264014209 Predicted transcriptional regulator [Transcription]; Region: COG1959 266264014210 Transcriptional regulator; Region: Rrf2; pfam02082 266264014211 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 266264014212 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266264014213 putative substrate translocation pore; other site 266264014214 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266264014215 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 266264014216 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 266264014217 HlyD family secretion protein; Region: HlyD_3; pfam13437 266264014218 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 266264014219 Cupin domain; Region: Cupin_2; pfam07883 266264014220 Uncharacterized conserved protein [Function unknown]; Region: COG2128 266264014221 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 266264014222 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266264014223 DNA-binding site [nucleotide binding]; DNA binding site 266264014224 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 266264014225 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 266264014226 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266264014227 homodimer interface [polypeptide binding]; other site 266264014228 catalytic residue [active] 266264014229 short chain dehydrogenase; Provisional; Region: PRK07577 266264014230 classical (c) SDRs; Region: SDR_c; cd05233 266264014231 NAD(P) binding site [chemical binding]; other site 266264014232 active site 266264014233 DNA-binding transcriptional activator FeaR; Provisional; Region: PRK09685 266264014234 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 266264014235 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 266264014236 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 266264014237 Cytochrome cbb3 oxidase subunit I. Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction...; Region: cbb3_Oxidase_I; cd01661 266264014238 Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115 266264014239 Low-spin heme binding site [chemical binding]; other site 266264014240 Putative water exit pathway; other site 266264014241 Binuclear center (active site) [active] 266264014242 Putative proton exit pathway; other site 266264014243 Cytochrome C oxidase, mono-heme subunit/FixO; Region: FixO; cl01130 266264014244 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 266264014245 Cytochrome c; Region: Cytochrom_C; pfam00034 266264014246 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 266264014247 Cu(I) binding site [ion binding]; other site 266264014248 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266264014249 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 266264014250 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 266264014251 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 266264014252 Predicted transcriptional regulator [Transcription]; Region: COG1959 266264014253 Transcriptional regulator; Region: Rrf2; pfam02082 266264014254 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 266264014255 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 266264014256 membrane-bound complex binding site; other site 266264014257 hinge residues; other site 266264014258 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 266264014259 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 266264014260 Walker A/P-loop; other site 266264014261 ATP binding site [chemical binding]; other site 266264014262 Q-loop/lid; other site 266264014263 ABC transporter signature motif; other site 266264014264 Walker B; other site 266264014265 D-loop; other site 266264014266 H-loop/switch region; other site 266264014267 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 266264014268 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 266264014269 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 266264014270 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 266264014271 active site 266264014272 4Fe-4S binding domain; Region: Fer4; cl02805 266264014273 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 266264014274 Succinate dehydrogenase/fumarate reductase, flavoprotein subunit [Energy production and conversion]; Region: SdhA; COG1053 266264014275 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 266264014276 Fatty acid desaturase protein family subgroup, a delta-12 acyl-lipid desaturase-like, DesA-like, yet uncharacterized subgroup of membrane fatty acid desaturase proteins found in alpha-, beta-, and gamma-proteobacteria. Sequences of this domain family...; Region: DesA_FADS-like; cd03509 266264014277 Fatty acid desaturase; Region: FA_desaturase; pfam00487 266264014278 putative di-iron ligands [ion binding]; other site 266264014279 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 266264014280 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 266264014281 active site residue [active] 266264014282 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 266264014283 active site residue [active] 266264014284 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 266264014285 active site residue [active] 266264014286 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 266264014287 active site residue [active] 266264014288 histidine kinase 266264014289 malate:quinone oxidoreductase; Validated; Region: PRK05257 266264014290 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 266264014291 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 266264014292 Argininosuccinate lyase [Amino acid transport and metabolism]; Region: ArgH; COG0165 266264014293 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 266264014294 active sites [active] 266264014295 tetramer interface [polypeptide binding]; other site 266264014296 DNA-binding transcriptional regulator LysR; Provisional; Region: PRK11013 266264014297 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266264014298 The C-terminal substrate-domain of LysR-type transcriptional regulator, NocR, involved in the catabolism of nopaline, contains the type 2 periplasmic binding fold; Region: PBP2_NocR; cd08458 266264014299 putative dimerization interface [polypeptide binding]; other site 266264014300 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 266264014301 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 266264014302 trimer interface [polypeptide binding]; other site 266264014303 eyelet of channel; other site 266264014304 conserved hypothetical protein 266264014305 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 266264014306 hypothetical protein 266264014307 hypothetical protein 266264014308 Protein with unknown function (DUF469); Region: DUF469; pfam04320 266264014309 UvrD/REP helicase family protein 266264014310 hypothetical protein 266264014311 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2343 266264014312 Transcriptional regulators [Transcription]; Region: GntR; COG1802 266264014313 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266264014314 DNA-binding site [nucleotide binding]; DNA binding site 266264014315 FCD domain; Region: FCD; pfam07729 266264014316 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 266264014317 PAS domain; Region: PAS_9; pfam13426 266264014318 putative active site [active] 266264014319 heme pocket [chemical binding]; other site 266264014320 helix_turn_helix, Lux Regulon; Region: HTH_LUXR; smart00421 266264014321 dimerization interface [polypeptide binding]; other site 266264014322 DNA binding residues [nucleotide binding] 266264014323 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 266264014324 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 266264014325 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 266264014326 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 266264014327 Transcriptional regulators [Transcription]; Region: GntR; COG1802 266264014328 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266264014329 DNA-binding site [nucleotide binding]; DNA binding site 266264014330 FCD domain; Region: FCD; pfam07729 266264014331 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 266264014332 CoA binding domain; Region: CoA_binding; pfam02629 266264014333 CoA-ligase; Region: Ligase_CoA; pfam00549 266264014334 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 266264014335 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 266264014336 CoA-ligase; Region: Ligase_CoA; pfam00549 266264014337 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 266264014338 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 266264014339 PYR/PP interface [polypeptide binding]; other site 266264014340 dimer interface [polypeptide binding]; other site 266264014341 TPP binding site [chemical binding]; other site 266264014342 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 266264014343 Thiamine pyrophosphate (TPP) family, BZL_OCoD_HPCL subfamily, TPP-binding module; composed of proteins similar to benzaldehyde lyase (BZL), oxalyl-CoA decarboxylase (OCoD) and 2-hydroxyphytanoyl-CoA lyase (2-HPCL). Pseudomonas fluorescens biovar I BZL...; Region: TPP_BZL_OCoD_HPCL; cd02004 266264014344 TPP-binding site; other site 266264014345 dimer interface [polypeptide binding]; other site 266264014346 formyl-coenzyme A transferase; Provisional; Region: PRK05398 266264014347 CoA-transferase family III; Region: CoA_transf_3; pfam02515 266264014348 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 266264014349 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 266264014350 acetyl coenzyme A synthetase (ADP forming), alpha domain; Region: AcCoA-syn-alpha; TIGR02717 266264014351 CoA binding domain; Region: CoA_binding_2; pfam13380 266264014352 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 266264014353 Domain of unknown function (DUF2437); Region: DUF2437; pfam10370 266264014354 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 266264014355 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 266264014356 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266264014357 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266264014358 The C-terminal substrate binding of LysR-type transcriptional regulator (CbbR) of RubisCO operon, which is involved in the carbon dioxide fixation, contains the type 2 periplasmic binding fold; Region: PBP2_CbbR_RubisCO_like; cd08419 266264014359 putative dimerization interface [polypeptide binding]; other site 266264014360 oxalate/formate antiporter; Region: oxa_formateAnti; TIGR04259 266264014361 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266264014362 putative substrate translocation pore; other site 266264014363 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266264014364 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266264014365 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 266264014366 putative dimerization interface [polypeptide binding]; other site 266264014367 oxalate/formate antiporter; Region: oxa_formateAnti; TIGR04259 266264014368 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266264014369 putative substrate translocation pore; other site 266264014370 Arginate lyase and other MDR family members; Region: AL_MDR; cd08252 266264014371 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817 266264014372 putative NAD(P) binding site [chemical binding]; other site 266264014373 dimer interface [polypeptide binding]; other site 266264014374 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 266264014375 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 266264014376 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 266264014377 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 266264014378 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 266264014379 sequence-specific DNA binding site [nucleotide binding]; other site 266264014380 salt bridge; other site 266264014381 homogentisate 1,2-dioxygenase; Provisional; Region: PRK05341 266264014382 fumarylacetoacetase; Region: PLN02856 266264014383 Domain of unknown function (DUF1969); Region: DUF1969; pfam09298 266264014384 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 266264014385 Beta-ketoacyl synthase, N-terminal domain; Region: Ketoacyl-synt_2; pfam13723 266264014386 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 266264014387 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 266264014388 putative acyl-acceptor binding pocket; other site 266264014389 Phosphopantetheine attachment site; Region: PP-binding; cl09936 266264014390 Phosphopantetheine attachment site; Region: PP-binding; cl09936 266264014391 Predicted membrane protein [Function unknown]; Region: COG4648 266264014392 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 266264014393 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 266264014394 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 266264014395 AMP binding site [chemical binding]; other site 266264014396 active site 266264014397 acyl-activating enzyme (AAE) consensus motif; other site 266264014398 acyl-activating enzyme (AAE) consensus motif; other site 266264014399 CoA binding site [chemical binding]; other site 266264014400 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 266264014401 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 266264014402 Ligand binding site; other site 266264014403 Putative Catalytic site; other site 266264014404 DXD motif; other site 266264014405 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 266264014406 putative acyl-acceptor binding pocket; other site 266264014407 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 266264014408 active site 266264014409 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl17548 266264014410 Predicted exporter [General function prediction only]; Region: COG4258 266264014411 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 266264014412 Glyoxalase-like domain; Region: Glyoxalase_2; pfam12681 266264014413 Protein of unknown function (DUF3261); Region: DUF3261; pfam11659 266264014414 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK09185 266264014415 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 266264014416 dimer interface [polypeptide binding]; other site 266264014417 active site 266264014418 Domain of unknown function, appears to be related to a diverse group of beta-hydroxydecanoyl ACP dehydratases (FabA) and beta-hydroxyacyl ACP dehydratases (FabZ). This group appears to lack the conserved active site histidine of FabA and FabZ; Region: FabA_like; cd01289 266264014419 putative active site 1 [active] 266264014420 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 266264014421 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 266264014422 NAD(P) binding site [chemical binding]; other site 266264014423 homotetramer interface [polypeptide binding]; other site 266264014424 homodimer interface [polypeptide binding]; other site 266264014425 active site 266264014426 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK09116 266264014427 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 266264014428 dimer interface [polypeptide binding]; other site 266264014429 active site 266264014430 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 266264014431 Transcriptional regulator [Transcription]; Region: IclR; COG1414 266264014432 Bacterial transcriptional regulator; Region: IclR; pfam01614 266264014433 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 266264014434 Ligand Binding Site [chemical binding]; other site 266264014435 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 266264014436 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 266264014437 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 266264014438 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266264014439 dimer interface [polypeptide binding]; other site 266264014440 conserved gate region; other site 266264014441 putative PBP binding loops; other site 266264014442 ABC-ATPase subunit interface; other site 266264014443 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 266264014444 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266264014445 dimer interface [polypeptide binding]; other site 266264014446 conserved gate region; other site 266264014447 putative PBP binding loops; other site 266264014448 ABC-ATPase subunit interface; other site 266264014449 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 266264014450 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 266264014451 Walker A/P-loop; other site 266264014452 ATP binding site [chemical binding]; other site 266264014453 Q-loop/lid; other site 266264014454 ABC transporter signature motif; other site 266264014455 Walker B; other site 266264014456 D-loop; other site 266264014457 H-loop/switch region; other site 266264014458 TOBE domain; Region: TOBE_2; pfam08402 266264014459 Protein of unknown function (DUF3562); Region: DUF3562; pfam12085 266264014460 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 266264014461 EamA-like transporter family; Region: EamA; pfam00892 266264014462 EamA-like transporter family; Region: EamA; pfam00892 266264014463 squalene-hopene cyclase; Region: hopene_cyclase; TIGR01507 266264014464 Squalene cyclase (SQCY) domain subgroup 1; found in class II terpene cyclases that have an alpha 6 - alpha 6 barrel fold. Squalene cyclase (SQCY) and 2,3-oxidosqualene cyclase (OSQCY) are integral membrane proteins that catalyze a cationic cyclization...; Region: SQCY_1; cd02892 266264014465 Active site cavity [active] 266264014466 catalytic acid [active] 266264014467 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 266264014468 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 266264014469 Iron-binding zinc finger CDGSH type; Region: zf-CDGSH; pfam09360 266264014470 conserved hypothetical protein (fragment) 266264014471 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 266264014472 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 266264014473 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 266264014474 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 266264014475 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 266264014476 active site 266264014477 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 266264014478 CoA binding domain; Region: CoA_binding_2; pfam13380 266264014479 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 266264014480 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 266264014481 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 266264014482 DUF35 OB-fold domain; Region: DUF35; pfam01796 266264014483 acetyl-CoA acetyltransferase; Provisional; Region: PRK08142 266264014484 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 266264014485 active site 266264014486 short chain dehydrogenase; Provisional; Region: PRK07791 266264014487 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266264014488 NAD(P) binding site [chemical binding]; other site 266264014489 active site 266264014490 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 266264014491 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 266264014492 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266264014493 DNA-binding site [nucleotide binding]; DNA binding site 266264014494 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 266264014495 extra-cytoplasmic solute receptor protein(fragment see also Rmet_4419 for the other fragment) 266264014496 Helix-turn-helix domain; Region: HTH_38; pfam13936 266264014497 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 266264014498 Integrase core domain; Region: rve; pfam00665 266264014499 extra-cytoplasmic solute receptor (Bug) 266264014500 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 266264014501 CoA-transferase family III; Region: CoA_transf_3; pfam02515 266264014502 2-methylcitrate dehydratase (PrpD)family MmgE/PrpD family protein 266264014503 AAA domain; Region: AAA_22; pfam13401 266264014504 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 266264014505 Walker A motif; other site 266264014506 ATP binding site [chemical binding]; other site 266264014507 Walker B motif; other site 266264014508 arginine finger; other site 266264014509 Integrase core domain; Region: rve; pfam00665 266264014510 MmgE/PrpD family protein 266264014511 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 266264014512 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 266264014513 active site 266264014514 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 266264014515 putative active site [active] 266264014516 putative catalytic site [active] 266264014517 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 266264014518 active site 2 [active] 266264014519 active site 1 [active] 266264014520 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 266264014521 hypothetical protein 266264014522 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 266264014523 Uncharacterized Candidatus pelagibacter aldehyde dehydrogenase, DhaS-like; Region: ALDH_DhaS; cd07114 266264014524 NAD(P) binding site [chemical binding]; other site 266264014525 catalytic residues [active] 266264014526 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 266264014527 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 266264014528 NAD binding site [chemical binding]; other site 266264014529 Transcriptional regulator [Transcription]; Region: IclR; COG1414 266264014530 Bacterial transcriptional regulator; Region: IclR; pfam01614 266264014531 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 266264014532 Protein of unknown function (DUF1697); Region: DUF1697; cl01557 266264014533 nitrilase; Region: PLN02798 266264014534 Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572 266264014535 putative active site [active] 266264014536 catalytic triad [active] 266264014537 dimer interface [polypeptide binding]; other site 266264014538 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 266264014539 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 266264014540 N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653 266264014541 D-aminoacylases (N-acyl-D-Amino acid amidohydrolases) catalyze the hydrolysis of N-acyl-D-amino acids to produce the corresponding D-amino acids, which are used as intermediates in the synthesis of pesticides, bioactive peptides, and antibiotics; Region: D-aminoacylase; cd01297 266264014542 active site 266264014543 putative substrate binding pocket [chemical binding]; other site 266264014544 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 266264014545 homotrimer interaction site [polypeptide binding]; other site 266264014546 putative active site [active] 266264014547 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 266264014548 hydroxyglutarate oxidase; Provisional; Region: PRK11728 266264014549 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266264014550 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266264014551 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 266264014552 dimerization interface [polypeptide binding]; other site 266264014553 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 266264014554 DNA-binding transcriptional regulator LysR; Provisional; Region: PRK11013 266264014555 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266264014556 The C-terminal substrate-domain of LysR-type transcriptional regulators involved in the catabolism of opines and that of related regulators, contains the type 2 periplasmic binding fold; Region: PBP2_LysR_opines_like; cd08415 266264014557 putative dimerization interface [polypeptide binding]; other site 266264014558 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 266264014559 CoA-transferase family III; Region: CoA_transf_3; pfam02515 266264014560 Transcriptional regulators [Transcription]; Region: FadR; COG2186 266264014561 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266264014562 DNA-binding site [nucleotide binding]; DNA binding site 266264014563 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 266264014564 enoyl-CoA hydratase; Provisional; Region: PRK06127 266264014565 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 266264014566 substrate binding site [chemical binding]; other site 266264014567 oxyanion hole (OAH) forming residues; other site 266264014568 trimer interface [polypeptide binding]; other site 266264014569 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 266264014570 conserved hypothetical protein; exported protein 266264014571 transcription regulator protein (fragment) 266264014572 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 266264014573 Ligand Binding Site [chemical binding]; other site 266264014574 Response regulator receiver domain; Region: Response_reg; pfam00072 266264014575 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 266264014576 conserved hypothetical protein; exported protein 266264014577 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08314 266264014578 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 266264014579 acyl-activating enzyme (AAE) consensus motif; other site 266264014580 putative AMP binding site [chemical binding]; other site 266264014581 putative active site [active] 266264014582 putative CoA binding site [chemical binding]; other site 266264014583 Putative cyclase; Region: Cyclase; pfam04199 266264014584 Cupin domain; Region: Cupin_2; pfam07883 266264014585 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 266264014586 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 266264014587 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 266264014588 active site 266264014589 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 266264014590 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 266264014591 MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300 266264014592 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 266264014593 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 266264014594 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 266264014595 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 266264014596 metal binding site [ion binding]; metal-binding site 266264014597 active site 266264014598 I-site; other site 266264014599 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 266264014600 DNA-binding protein H-NS [General function prediction only]; Region: Hns; COG2916 266264014601 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 266264014602 Helix-turn-helix domain; Region: HTH_38; pfam13936 266264014603 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 266264014604 Integrase core domain; Region: rve; pfam00665 266264014605 heavy metal response regulator; Region: cztR_silR_copR; TIGR01387 266264014606 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266264014607 active site 266264014608 phosphorylation site [posttranslational modification] 266264014609 intermolecular recognition site; other site 266264014610 dimerization interface [polypeptide binding]; other site 266264014611 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 266264014612 DNA binding site [nucleotide binding] 266264014613 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 266264014614 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 266264014615 dimer interface [polypeptide binding]; other site 266264014616 phosphorylation site [posttranslational modification] 266264014617 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266264014618 ATP binding site [chemical binding]; other site 266264014619 Mg2+ binding site [ion binding]; other site 266264014620 G-X-G motif; other site 266264014621 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 266264014622 dimer interface [polypeptide binding]; other site 266264014623 heavy metal efflux pump, CzcA family; Region: 2A0601; TIGR00914 266264014624 heavy metal cation tricomponent efflux, membrane fusion protein CzcB2(CzcB-like) 266264014625 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 266264014626 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 266264014627 Ligand Binding Site [chemical binding]; other site 266264014628 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 266264014629 Ligand Binding Site [chemical binding]; other site 266264014630 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 266264014631 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 266264014632 Sulfate transporter family; Region: Sulfate_transp; pfam00916 266264014633 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 266264014634 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 266264014635 multiple promoter invertase; Provisional; Region: mpi; PRK13413 266264014636 catalytic residues [active] 266264014637 catalytic nucleophile [active] 266264014638 Presynaptic Site I dimer interface [polypeptide binding]; other site 266264014639 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 266264014640 Synaptic Flat tetramer interface [polypeptide binding]; other site 266264014641 Synaptic Site I dimer interface [polypeptide binding]; other site 266264014642 DNA binding site [nucleotide binding] 266264014643 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 266264014644 DNA-binding interface [nucleotide binding]; DNA binding site 266264014645 Domain of unknown function (DUF4158); Region: DUF4158; pfam13700 266264014646 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; pfam01526 266264014647 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 266264014648 Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327 266264014649 putative ligand binding site [chemical binding]; other site 266264014650 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 266264014651 TM-ABC transporter signature motif; other site 266264014652 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 266264014653 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 266264014654 TM-ABC transporter signature motif; other site 266264014655 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 266264014656 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 266264014657 Walker A/P-loop; other site 266264014658 ATP binding site [chemical binding]; other site 266264014659 Q-loop/lid; other site 266264014660 ABC transporter signature motif; other site 266264014661 Walker B; other site 266264014662 D-loop; other site 266264014663 H-loop/switch region; other site 266264014664 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 266264014665 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 266264014666 Walker A/P-loop; other site 266264014667 ATP binding site [chemical binding]; other site 266264014668 Q-loop/lid; other site 266264014669 ABC transporter signature motif; other site 266264014670 Walker B; other site 266264014671 D-loop; other site 266264014672 H-loop/switch region; other site 266264014673 allantoate amidohydrolase; Reviewed; Region: PRK12893 266264014674 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 266264014675 active site 266264014676 metal binding site [ion binding]; metal-binding site 266264014677 dimer interface [polypeptide binding]; other site 266264014678 Uncharacterized conserved protein [Function unknown]; Region: COG5476 266264014679 Protein of unknown function (DUF1485); Region: DUF1485; pfam07364 266264014680 MlrC C-terminus; Region: MlrC_C; pfam07171 266264014681 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 266264014682 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 266264014683 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 266264014684 CoenzymeA binding site [chemical binding]; other site 266264014685 subunit interaction site [polypeptide binding]; other site 266264014686 PHB binding site; other site 266264014687 RibD C-terminal domain; Region: RibD_C; cl17279 266264014688 Protein of unknown function (DUF342); Region: DUF342; pfam03961 266264014689 hypothetical protein 266264014690 conserved hypothetical protein (fragment) 266264014691 Zonular occludens toxin (Zot); Region: Zot; cl17485 266264014692 hypothetical protein 266264014693 phage function unknown 266264014694 conserved hypothetical protein (phage protein) 266264014695 phage major tail protein (fragment?) 266264014696 transposase (fragment) 266264014697 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 266264014698 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 266264014699 N-terminal plug; other site 266264014700 ligand-binding site [chemical binding]; other site 266264014701 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 266264014702 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 266264014703 N-terminal plug; other site 266264014704 ligand-binding site [chemical binding]; other site 266264014705 fec operon regulator FecR; Reviewed; Region: PRK09774 266264014706 FecR protein; Region: FecR; pfam04773 266264014707 RNA polymerase sigma factor; Provisional; Region: PRK12528 266264014708 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 266264014709 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 266264014710 DNA binding residues [nucleotide binding] 266264014711 hypothetical protein 266264014712 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 266264014713 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08314 266264014714 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 266264014715 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 266264014716 acyl-activating enzyme (AAE) consensus motif; other site 266264014717 AMP binding site [chemical binding]; other site 266264014718 active site 266264014719 CoA binding site [chemical binding]; other site 266264014720 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 266264014721 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 266264014722 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 266264014723 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 266264014724 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266264014725 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266264014726 LysR substrate binding domain; Region: LysR_substrate; pfam03466 266264014727 dimerization interface [polypeptide binding]; other site 266264014728 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266264014729 metabolite-proton symporter; Region: 2A0106; TIGR00883 266264014730 putative substrate translocation pore; other site 266264014731 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 266264014732 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 266264014733 metal binding site [ion binding]; metal-binding site 266264014734 putative dimer interface [polypeptide binding]; other site 266264014735 Flagellar protein YcgR; Region: YcgR_2; pfam12945 266264014736 PilZ domain; Region: PilZ; pfam07238 266264014737 multidrug resistance protein MdtN; Provisional; Region: PRK10476 266264014738 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 266264014739 HlyD family secretion protein; Region: HlyD_3; pfam13437 266264014740 Fusaric acid resistance protein family; Region: FUSC; pfam04632 266264014741 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 266264014742 Outer membrane efflux protein; Region: OEP; pfam02321 266264014743 Outer membrane efflux protein; Region: OEP; pfam02321 266264014744 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 266264014745 active site 1 [active] 266264014746 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 266264014747 active site 2 [active] 266264014748 active site 1 [active] 266264014749 Phage integrase protein; Region: DUF3701; pfam12482 266264014750 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N2; pfam13495 266264014751 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 266264014752 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 266264014753 INT_SG1, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 1, C-terminal catalytic domain. The CD contains mainly predicted integrase/recombinase and site-specific XerD recombinases. The members of this CD are found predominantly in...; Region: INT_SG1_C; cd01183 266264014754 Int/Topo IB signature motif; other site 266264014755 PAS domain S-box; Region: sensory_box; TIGR00229 266264014756 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 266264014757 putative active site [active] 266264014758 heme pocket [chemical binding]; other site 266264014759 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 266264014760 Histidine kinase; Region: HisKA_3; pfam07730 266264014761 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266264014762 ATP binding site [chemical binding]; other site 266264014763 Mg2+ binding site [ion binding]; other site 266264014764 G-X-G motif; other site 266264014765 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 266264014766 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266264014767 active site 266264014768 phosphorylation site [posttranslational modification] 266264014769 intermolecular recognition site; other site 266264014770 dimerization interface [polypeptide binding]; other site 266264014771 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 266264014772 DNA binding residues [nucleotide binding] 266264014773 dimerization interface [polypeptide binding]; other site 266264014774 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 266264014775 Ligand Binding Site [chemical binding]; other site 266264014776 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 266264014777 Ligand Binding Site [chemical binding]; other site 266264014778 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 266264014779 Ligand Binding Site [chemical binding]; other site 266264014780 Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236 266264014781 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 266264014782 Beta-Casp domain; Region: Beta-Casp; smart01027 266264014783 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 266264014784 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 266264014785 Ligand Binding Site [chemical binding]; other site 266264014786 fumarate/nitrate reduction transcriptional regulator; Provisional; Region: PRK11161 266264014787 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 266264014788 ligand binding site [chemical binding]; other site 266264014789 flexible hinge region; other site 266264014790 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 266264014791 putative switch regulator; other site 266264014792 non-specific DNA interactions [nucleotide binding]; other site 266264014793 DNA binding site [nucleotide binding] 266264014794 sequence specific DNA binding site [nucleotide binding]; other site 266264014795 putative cAMP binding site [chemical binding]; other site 266264014796 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 266264014797 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 266264014798 conserved cys residue [active] 266264014799 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 266264014800 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 266264014801 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266264014802 NAD(P) binding site [chemical binding]; other site 266264014803 active site 266264014804 Transcriptional regulator [Transcription]; Region: PaiB; COG2808 266264014805 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 266264014806 Protein of unknown function DUF58; Region: DUF58; pfam01882 266264014807 MoxR-like ATPases [General function prediction only]; Region: COG0714 266264014808 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 266264014809 Walker A motif; other site 266264014810 ATP binding site [chemical binding]; other site 266264014811 Walker B motif; other site 266264014812 arginine finger; other site 266264014813 spermidine synthase; Provisional; Region: PRK03612 266264014814 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 266264014815 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 266264014816 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 266264014817 motif II; other site 266264014818 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 266264014819 Uncharacterized conserved protein [Function unknown]; Region: COG1262 266264014820 Oxygen tolerance; Region: BatD; pfam13584 266264014821 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 266264014822 metal ion-dependent adhesion site (MIDAS); other site 266264014823 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 266264014824 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 266264014825 TPR motif; other site 266264014826 binding surface 266264014827 VWA BatA type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_BatA_type; cd01467 266264014828 metal ion-dependent adhesion site (MIDAS); other site 266264014829 Domain of unknown function (DUF4381); Region: DUF4381; pfam14316 266264014830 tyrosine-based site-specific recombinase activity (fragment) 266264014831 tyrosine-based site-specific recombinase activity (fragment) 266264014832 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; pfam13557 266264014833 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790 266264014834 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176 266264014835 ligand binding site [chemical binding]; other site 266264014836 NAD binding site [chemical binding]; other site 266264014837 tetramer interface [polypeptide binding]; other site 266264014838 catalytic site [active] 266264014839 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 266264014840 L-serine binding site [chemical binding]; other site 266264014841 ACT domain interface; other site 266264014842 Helix-Turn-Helix DNA binding domain of the SoxR transcription regulator; Region: HTH_SoxR; cd01110 266264014843 redox-sensitive transcriptional activator SoxR; Region: SoxR; TIGR01950 266264014844 DNA binding residues [nucleotide binding] 266264014845 dimer interface [polypeptide binding]; other site 266264014846 [2Fe-2S] cluster binding site [ion binding]; other site 266264014847 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 266264014848 homotrimer interaction site [polypeptide binding]; other site 266264014849 putative active site [active] 266264014850 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266264014851 Major Facilitator Superfamily; Region: MFS_1; pfam07690 266264014852 putative substrate translocation pore; other site 266264014853 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266264014854 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266264014855 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266264014856 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 266264014857 putative effector binding pocket; other site 266264014858 putative dimerization interface [polypeptide binding]; other site 266264014859 short chain dehydrogenase; Provisional; Region: PRK12937 266264014860 tetrahydroxynaphthalene/trihydroxynaphthalene reductase-like, classical (c) SDRs; Region: THN_reductase-like_SDR_c; cd05362 266264014861 NADP binding site [chemical binding]; other site 266264014862 homodimer interface [polypeptide binding]; other site 266264014863 active site 266264014864 substrate binding site [chemical binding]; other site 266264014865 Predicted transcriptional regulators [Transcription]; Region: COG1733 266264014866 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 266264014867 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 266264014868 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 266264014869 trimer interface [polypeptide binding]; other site 266264014870 eyelet of channel; other site 266264014871 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 266264014872 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 266264014873 Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178 266264014874 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 266264014875 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 266264014876 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 266264014877 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 266264014878 Walker A/P-loop; other site 266264014879 ATP binding site [chemical binding]; other site 266264014880 Q-loop/lid; other site 266264014881 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 266264014882 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 266264014883 conserved hypothetical protein (fragment?) 266264014884 conserved hypothetical protein (fragment?) 266264014885 hypothetical protein; exported protein 266264014886 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 266264014887 Bulb-type mannose-specific lectin. The domain contains a three-fold internal repeat (beta-prism architecture). The consensus sequence motif QXDXNXVXY is involved in alpha-D-mannose recognition. Lectins are carbohydrate-binding proteins which specifically...; Region: B_lectin; cd00028 266264014888 dimerization interface [polypeptide binding]; other site 266264014889 D-mannose binding lectin; Region: B_lectin; pfam01453 266264014890 mannose binding site [chemical binding]; other site 266264014891 Bulb-type mannose-specific lectin. The domain contains a three-fold internal repeat (beta-prism architecture). The consensus sequence motif QXDXNXVXY is involved in alpha-D-mannose recognition. Lectins are carbohydrate-binding proteins which specifically...; Region: B_lectin; cd00028 266264014892 D-mannose binding lectin; Region: B_lectin; pfam01453 266264014893 mannose binding site [chemical binding]; other site 266264014894 transposase IS3/IS911 family (fragment) 266264014895 hypothetical protein 266264014896 transposase catalytic domain family IS3/IS911 (fragment) 266264014897 catalytic domain:Transposase IS3/IS911 (fragment) 266264014898 Tyr recombinase activity site-specific recombination (fragment) 266264014899 methionine sulfoxide reductase A; Provisional; Region: PRK14054 266264014900 Uncharacterized subfamily of Uracil-DNA glycosylases; Region: UDG_like_1; cd10033 266264014901 putative uracil binding site [chemical binding]; other site 266264014902 putative active site [active] 266264014903 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 266264014904 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 266264014905 putative DNA binding site [nucleotide binding]; other site 266264014906 putative Zn2+ binding site [ion binding]; other site 266264014907 AsnC family; Region: AsnC_trans_reg; pfam01037 266264014908 EamA-like transporter family; Region: EamA; pfam00892 266264014909 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 266264014910 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 266264014911 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 266264014912 AsnC family; Region: AsnC_trans_reg; pfam01037 266264014913 DNA-binding transcriptional regulator MetR; Provisional; Region: PRK15421 266264014914 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266264014915 The C-terminal substrate binding domain of LysR-type transcriptional regulator metR, which regulates the expression of methionine biosynthetic genes, contains type 2 periplasmic binding fold; Region: PBP2_MetR; cd08441 266264014916 putative dimerization interface [polypeptide binding]; other site 266264014917 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 266264014918 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 266264014919 THF binding site; other site 266264014920 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 266264014921 substrate binding site [chemical binding]; other site 266264014922 THF binding site; other site 266264014923 zinc-binding site [ion binding]; other site 266264014924 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 266264014925 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 266264014926 N-terminal plug; other site 266264014927 ligand-binding site [chemical binding]; other site 266264014928 Uncharacterized conserved protein [Function unknown]; Region: COG5361 266264014929 Protein of unknown function (DUF1254); Region: DUF1254; pfam06863 266264014930 Protein of unknown function (DUF1214); Region: DUF1214; pfam06742 266264014931 cytosine deaminase; Validated; Region: PRK07572 266264014932 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 266264014933 active site 266264014934 pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613 266264014935 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 266264014936 YcdC-like protein, C-terminal region; Region: TetR_C_3; pfam08362 266264014937 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 266264014938 active site 266264014939 Protein of unknown function (DUF1688); Region: DUF1688; pfam07958 266264014940 hypothetical protein; Validated; Region: PRK07198 266264014941 GTP cyclohydrolase N terminal; Region: GTP_CH_N; pfam12471 266264014942 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 266264014943 dimerization interface [polypeptide binding]; other site 266264014944 active site 266264014945 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 266264014946 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 266264014947 pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204 266264014948 active site 266264014949 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 266264014950 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 266264014951 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 266264014952 active site 266264014953 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 266264014954 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266264014955 dimer interface [polypeptide binding]; other site 266264014956 conserved gate region; other site 266264014957 putative PBP binding loops; other site 266264014958 ABC-ATPase subunit interface; other site 266264014959 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 266264014960 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 266264014961 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266264014962 dimer interface [polypeptide binding]; other site 266264014963 conserved gate region; other site 266264014964 putative PBP binding loops; other site 266264014965 ABC-ATPase subunit interface; other site 266264014966 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 266264014967 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 266264014968 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 266264014969 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 266264014970 Walker A/P-loop; other site 266264014971 ATP binding site [chemical binding]; other site 266264014972 Q-loop/lid; other site 266264014973 ABC transporter signature motif; other site 266264014974 Walker B; other site 266264014975 D-loop; other site 266264014976 H-loop/switch region; other site 266264014977 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 266264014978 oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079 266264014979 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 266264014980 Walker A/P-loop; other site 266264014981 ATP binding site [chemical binding]; other site 266264014982 Q-loop/lid; other site 266264014983 ABC transporter signature motif; other site 266264014984 Walker B; other site 266264014985 D-loop; other site 266264014986 H-loop/switch region; other site 266264014987 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 266264014988 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 266264014989 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 266264014990 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 266264014991 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 266264014992 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 266264014993 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 266264014994 substrate binding site [chemical binding]; other site 266264014995 oxyanion hole (OAH) forming residues; other site 266264014996 trimer interface [polypeptide binding]; other site 266264014997 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 266264014998 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 266264014999 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 266264015000 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 266264015001 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 266264015002 substrate binding pocket [chemical binding]; other site 266264015003 membrane-bound complex binding site; other site 266264015004 hinge residues; other site 266264015005 dihydroxy-acid dehydratase; Provisional; Region: PRK12448 266264015006 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 266264015007 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 266264015008 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnE; Provisional; Region: PRK15051 266264015009 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 266264015010 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 266264015011 inhibitor-cofactor binding pocket; inhibition site 266264015012 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266264015013 catalytic residue [active] 266264015014 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 266264015015 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 266264015016 Ligand binding site; other site 266264015017 Putative Catalytic site; other site 266264015018 DXD motif; other site 266264015019 putative formyltransferase; Provisional; Region: PRK06988 266264015020 Formyltransferase, catalytic core domain; Region: FMT_core; cl00395 266264015021 active site 266264015022 substrate binding site [chemical binding]; other site 266264015023 cosubstrate binding site; other site 266264015024 catalytic site [active] 266264015025 C-terminal subdomain of the formyltransferase domain on ArnA, which modifies lipid A with 4-amino-4-deoxy-l-arabinose; Region: Arna_FMT_C; cd08702 266264015026 active site 266264015027 NAD-dependent epimerase/dehydratase family protein; Provisional; Region: PRK11908 266264015028 Arna decarboxylase_like, extended (e) SDRs; Region: Arna_like_SDR_e; cd05257 266264015029 NAD binding site [chemical binding]; other site 266264015030 substrate binding site [chemical binding]; other site 266264015031 active site 266264015032 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD; Provisional; Region: PRK15394 266264015033 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 266264015034 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 266264015035 Heavy-metal-associated domain; Region: HMA; pfam00403 266264015036 metal-binding site [ion binding] 266264015037 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 266264015038 Soluble P-type ATPase [General function prediction only]; Region: COG4087 266264015039 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 266264015040 heavy metal cation tricomponent efflux, membrane fusion protein (CzcB-like) 266264015041 Domain of unknown function (DUF4158); Region: DUF4158; pfam13700 266264015042 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; pfam01526 266264015043 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 266264015044 multiple promoter invertase; Provisional; Region: mpi; PRK13413 266264015045 catalytic residues [active] 266264015046 catalytic nucleophile [active] 266264015047 Presynaptic Site I dimer interface [polypeptide binding]; other site 266264015048 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 266264015049 Synaptic Flat tetramer interface [polypeptide binding]; other site 266264015050 Synaptic Site I dimer interface [polypeptide binding]; other site 266264015051 DNA binding site [nucleotide binding] 266264015052 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 266264015053 DNA-binding interface [nucleotide binding]; DNA binding site 266264015054 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 266264015055 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 266264015056 Sulfate transporter family; Region: Sulfate_transp; pfam00916 266264015057 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 266264015058 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 266264015059 Ligand Binding Site [chemical binding]; other site 266264015060 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 266264015061 Ligand Binding Site [chemical binding]; other site 266264015062 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 266264015063 Transcriptional regulators [Transcription]; Region: FadR; COG2186 266264015064 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266264015065 DNA-binding site [nucleotide binding]; DNA binding site 266264015066 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 266264015067 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 266264015068 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 266264015069 substrate binding pocket [chemical binding]; other site 266264015070 membrane-bound complex binding site; other site 266264015071 hinge residues; other site 266264015072 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 266264015073 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 266264015074 substrate binding pocket [chemical binding]; other site 266264015075 membrane-bound complex binding site; other site 266264015076 hinge residues; other site 266264015077 PAS fold; Region: PAS_4; pfam08448 266264015078 PAS fold; Region: PAS_3; pfam08447 266264015079 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 266264015080 dimer interface [polypeptide binding]; other site 266264015081 phosphorylation site [posttranslational modification] 266264015082 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266264015083 ATP binding site [chemical binding]; other site 266264015084 Mg2+ binding site [ion binding]; other site 266264015085 G-X-G motif; other site 266264015086 Response regulator receiver domain; Region: Response_reg; pfam00072 266264015087 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266264015088 active site 266264015089 phosphorylation site [posttranslational modification] 266264015090 intermolecular recognition site; other site 266264015091 dimerization interface [polypeptide binding]; other site 266264015092 O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873 266264015093 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 266264015094 homodimer interface [polypeptide binding]; other site 266264015095 substrate-cofactor binding pocket; other site 266264015096 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266264015097 catalytic residue [active] 266264015098 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 266264015099 N-terminal plug; other site 266264015100 TonB-dependent copper receptor; Region: TonB-copper; TIGR01778 266264015101 ligand-binding site [chemical binding]; other site 266264015102 Protein of unknown function (DUF2946); Region: DUF2946; pfam11162 266264015103 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 266264015104 Protein of unknown function (DUF1446); Region: DUF1446; pfam07287 266264015105 Transcriptional regulator [Transcription]; Region: IclR; COG1414 266264015106 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 266264015107 Bacterial transcriptional regulator; Region: IclR; pfam01614 266264015108 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 266264015109 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 266264015110 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 266264015111 active site 266264015112 short chain dehydrogenase; Provisional; Region: PRK06949 266264015113 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266264015114 NAD(P) binding site [chemical binding]; other site 266264015115 active site 266264015116 Transcriptional regulators [Transcription]; Region: GntR; COG1802 266264015117 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266264015118 DNA-binding site [nucleotide binding]; DNA binding site 266264015119 FCD domain; Region: FCD; pfam07729 266264015120 Protein of unknown function (DUF3626); Region: DUF3626; pfam12294 266264015121 Outer membrane receptor for monomeric catechols [Inorganic ion transport and metabolism]; Region: Fiu; COG4774 266264015122 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 266264015123 N-terminal plug; other site 266264015124 ligand-binding site [chemical binding]; other site 266264015125 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 266264015126 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 266264015127 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 266264015128 HlyD family secretion protein; Region: HlyD_3; pfam13437 266264015129 Protein of unknown function (DUF3302); Region: DUF3302; pfam11742 266264015130 phospholipase C, phosphocholine-specific, Pseudomonas-type; Region: PC_PLC; TIGR03396 266264015131 Phosphoesterase family; Region: Phosphoesterase; pfam04185 266264015132 Domain of unknown function (DUF756); Region: DUF756; pfam05506 266264015133 Domain of unknown function (DUF756); Region: DUF756; pfam05506 266264015134 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 266264015135 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 266264015136 phosphorylation site [posttranslational modification] 266264015137 dimer interface [polypeptide binding]; other site 266264015138 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266264015139 ATP binding site [chemical binding]; other site 266264015140 Mg2+ binding site [ion binding]; other site 266264015141 G-X-G motif; other site 266264015142 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266264015143 Response regulator receiver domain; Region: Response_reg; pfam00072 266264015144 active site 266264015145 phosphorylation site [posttranslational modification] 266264015146 intermolecular recognition site; other site 266264015147 dimerization interface [polypeptide binding]; other site 266264015148 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086 266264015149 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 266264015150 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266264015151 active site 266264015152 phosphorylation site [posttranslational modification] 266264015153 intermolecular recognition site; other site 266264015154 dimerization interface [polypeptide binding]; other site 266264015155 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 266264015156 DNA binding residues [nucleotide binding] 266264015157 dimerization interface [polypeptide binding]; other site 266264015158 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 266264015159 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 266264015160 NADP binding site [chemical binding]; other site 266264015161 dimer interface [polypeptide binding]; other site 266264015162 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 266264015163 Helix-turn-helix domain; Region: HTH_18; pfam12833 266264015164 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 266264015165 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 266264015166 Prokaryotic protein of unknown function (DUF849); Region: DUF849; pfam05853 266264015167 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 266264015168 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 266264015169 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 266264015170 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 266264015171 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 266264015172 DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases. They exists as monomers and homodimers; Region: NUC; cd00091 266264015173 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892 266264015174 active site 266264015175 substrate binding site [chemical binding]; other site 266264015176 Mg2+ binding site [ion binding]; other site 266264015177 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 266264015178 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 266264015179 Sulfate transporter family; Region: Sulfate_transp; pfam00916 266264015180 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 266264015181 Cytochrome c; Region: Cytochrom_C; pfam00034 266264015182 Ubiquitin-like proteins; Region: UBQ; cl00155 266264015183 VPS10 domain; Region: VPS10; smart00602 266264015184 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262 266264015185 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 266264015186 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 266264015187 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 266264015188 Walker A/P-loop; other site 266264015189 Walker A/P-loop; other site 266264015190 ATP binding site [chemical binding]; other site 266264015191 ATP binding site [chemical binding]; other site 266264015192 Q-loop/lid; other site 266264015193 ABC transporter signature motif; other site 266264015194 Walker B; other site 266264015195 D-loop; other site 266264015196 TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family. The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026 266264015197 putative active site [active] 266264015198 putative metal-binding site [ion binding]; other site 266264015199 Protein of unknown function (DUF2726); Region: DUF2726; pfam10881 266264015200 Uncharacterized conserved protein [Function unknown]; Region: COG2128 266264015201 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 266264015202 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 266264015203 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 266264015204 classical (c) SDRs; Region: SDR_c; cd05233 266264015205 NAD(P) binding site [chemical binding]; other site 266264015206 active site 266264015207 Transcriptional regulators [Transcription]; Region: PurR; COG1609 266264015208 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 266264015209 DNA binding site [nucleotide binding] 266264015210 domain linker motif; other site 266264015211 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_5; cd06281 266264015212 putative dimerization interface [polypeptide binding]; other site 266264015213 putative ligand binding site [chemical binding]; other site 266264015214 Fic family protein [Function unknown]; Region: COG3177 266264015215 Domain of unknown function (DUF4172); Region: DUF4172; pfam13776 266264015216 Fic/DOC family; Region: Fic; pfam02661 266264015217 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 266264015218 Predicted transcriptional regulators [Transcription]; Region: COG1733 266264015219 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 266264015220 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 266264015221 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 266264015222 HlyD family secretion protein; Region: HlyD_3; pfam13437 266264015223 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266264015224 Major Facilitator Superfamily; Region: MFS_1; pfam07690 266264015225 putative substrate translocation pore; other site 266264015226 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266264015227 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 266264015228 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 266264015229 active site 266264015230 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 266264015231 active sites [active] 266264015232 tetramer interface [polypeptide binding]; other site 266264015233 Uncharacterized conserved protein [Function unknown]; Region: COG1359 266264015234 diguanylate cyclase/phosphodiesterase; PAS, GGDEF and EAL domains 266264015235 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 266264015236 Transposase; Region: HTH_Tnp_1; cl17663 266264015237 putative transposase OrfB; Reviewed; Region: PHA02517 266264015238 HTH-like domain; Region: HTH_21; pfam13276 266264015239 Integrase core domain; Region: rve; pfam00665 266264015240 Integrase core domain; Region: rve_3; pfam13683 266264015241 diguanylate cyclase/phosphodiesterase; PAS, GGDEF and EAL domains 266264015242 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 266264015243 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 266264015244 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 266264015245 Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546 266264015246 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 266264015247 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 266264015248 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 266264015249 DNA binding residues [nucleotide binding] 266264015250 Protein of unknown function (DUF1275); Region: DUF1275; pfam06912 266264015251 Uncharacterized conserved protein [Function unknown]; Region: COG3339 266264015252 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 266264015253 S-adenosylmethionine binding site [chemical binding]; other site 266264015254 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 266264015255 dimerization domain swap beta strand [polypeptide binding]; other site 266264015256 regulatory protein interface [polypeptide binding]; other site 266264015257 active site 266264015258 regulatory phosphorylation site [posttranslational modification]; other site 266264015259 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 266264015260 Ni,Fe-hydrogenase III small subunit [Energy production and conversion]; Region: COG3260 266264015261 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl16917 266264015262 Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261 266264015263 NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338 266264015264 hydrogenase 4 subunit F; Validated; Region: PRK06458 266264015265 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 266264015266 Hydrogenase 4 membrane component (E) [Energy production and conversion]; Region: HyfE; cl17899 266264015267 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 266264015268 NADH dehydrogenase; Region: NADHdh; cl00469 266264015269 hydrogenase 4 subunit B; Validated; Region: PRK06521 266264015270 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 266264015271 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 266264015272 Uncharacterized conserved protein [Function unknown]; Region: COG1434 266264015273 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 266264015274 putative active site [active] 266264015275 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 266264015276 muconolactone delta-isomerase; Region: muco_delta; TIGR03221 266264015277 Putative cyclase; Region: Cyclase; pfam04199 266264015278 YciI-like protein; Reviewed; Region: PRK12863 266264015279 Short chain fatty acids transporter [Lipid metabolism]; Region: AtoE; COG2031 266264015280 Predicted membrane protein [Function unknown]; Region: COG2259 266264015281 Uncharacterized protein conserved in bacteria (DUF2063); Region: DUF2063; pfam09836 266264015282 hypothetical protein; Provisional; Region: PRK05409 266264015283 Predicted integral membrane protein (DUF2282); Region: DUF2282; pfam10048 266264015284 RNA polymerase sigma factor; Provisional; Region: PRK12536 266264015285 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 266264015286 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 266264015287 DNA binding residues [nucleotide binding] 266264015288 Protein of unknown function (DUF1109); Region: DUF1109; pfam06532 266264015289 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 266264015290 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209 266264015291 active site 266264015292 nucleophile elbow; other site 266264015293 Citrate transporter; Region: CitMHS; pfam03600 266264015294 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 266264015295 Intracellular septation protein A; Region: IspA; cl01098 266264015296 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 266264015297 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 266264015298 N-acetyl-D-glucosamine binding site [chemical binding]; other site 266264015299 catalytic residue [active] 266264015300 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 266264015301 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 266264015302 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 266264015303 Cu(I) binding site [ion binding]; other site 266264015304 nitrous oxide reductase family maturation protein NosD; Region: NosD_copper_fam; TIGR04247 266264015305 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 266264015306 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 266264015307 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 266264015308 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 266264015309 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 266264015310 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 266264015311 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 266264015312 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 266264015313 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 266264015314 type IV pilus secretin (or competence protein) PilQ; Region: IV_pilus_PilQ; TIGR02515 266264015315 Secretin and TonB N terminus short domain; Region: STN; smart00965 266264015316 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 266264015317 type III secretion apparatus protein, YscD/HrpQ family; Region: type_III_yscD; TIGR02500 266264015318 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804 266264015319 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 266264015320 Walker A motif; other site 266264015321 ATP binding site [chemical binding]; other site 266264015322 Walker B motif; other site 266264015323 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 266264015324 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 266264015325 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 266264015326 type II secretion system protein G; Region: typeII_sec_gspG; TIGR01710 266264015327 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 266264015328 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 266264015329 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 266264015330 PAS domain; Region: PAS_9; pfam13426 266264015331 putative active site [active] 266264015332 heme pocket [chemical binding]; other site 266264015333 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 266264015334 Histidine kinase; Region: HisKA_3; pfam07730 266264015335 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266264015336 ATP binding site [chemical binding]; other site 266264015337 Mg2+ binding site [ion binding]; other site 266264015338 G-X-G motif; other site 266264015339 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 266264015340 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266264015341 active site 266264015342 phosphorylation site [posttranslational modification] 266264015343 intermolecular recognition site; other site 266264015344 dimerization interface [polypeptide binding]; other site 266264015345 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 266264015346 DNA binding residues [nucleotide binding] 266264015347 dimerization interface [polypeptide binding]; other site 266264015348 Cupin superfamily (DUF985); Region: Cupin_5; pfam06172 266264015349 Cupin domain; Region: Cupin_2; cl17218 266264015350 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 266264015351 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 266264015352 hypothetical protein; Provisional; Region: PRK06489 266264015353 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 266264015354 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 266264015355 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 266264015356 WHG domain; Region: WHG; pfam13305 266264015357 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 266264015358 Putative catalytic domain, repeat 1, of Pseudomonas aeruginosa cardiolipin synthase and similar proteins; Region: PLDc_PaCLS_like_1; cd09155 266264015359 putative active site [active] 266264015360 catalytic site [active] 266264015361 Putative catalytic domain, repeat 2, of Pseudomonas aeruginosa cardiolipin synthase and similar proteins; Region: PLDc_PaCLS_like_2; cd09161 266264015362 putative active site [active] 266264015363 catalytic site [active] 266264015364 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 266264015365 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266264015366 active site 266264015367 phosphorylation site [posttranslational modification] 266264015368 intermolecular recognition site; other site 266264015369 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 266264015370 DNA binding site [nucleotide binding] 266264015371 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 266264015372 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the GGDEF (DiGuanylate-Cyclase (DGC)) domain. The GGDEF domain has been suggested to be homologous to the adenylyl cyclase catalytic domain and...; Region: CBS_pair_GGDEF_assoc; cd04598 266264015373 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 266264015374 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 266264015375 metal binding site [ion binding]; metal-binding site 266264015376 active site 266264015377 I-site; other site 266264015378 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 266264015379 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 266264015380 dimer interface [polypeptide binding]; other site 266264015381 putative CheW interface [polypeptide binding]; other site 266264015382 uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926 266264015383 alkylhydroperoxidase AhpD family core domain; Region: ahpD_dom; TIGR00778 266264015384 Cupin; Region: Cupin_6; pfam12852 266264015385 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 266264015386 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 266264015387 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 266264015388 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 266264015389 Transcriptional regulator [Transcription]; Region: IclR; COG1414 266264015390 Bacterial transcriptional regulator; Region: IclR; pfam01614 266264015391 5-carboxymethyl-2-hydroxymuconate isomerase (CHMI) is a trimeric enzyme catalyzing the isomerization of the unsaturated ketone 5-(carboxymethyl)-2-hydroxymuconate to 5-(carboxymethyl)-2-oxo-3-hexene-1,6-dionate. This is one step in the...; Region: CHMI; cd00580 266264015392 putative substrate binding pocket [chemical binding]; other site 266264015393 trimer interface [polypeptide binding]; other site 266264015394 galactarate dehydratase; Region: galactar-dH20; TIGR03248 266264015395 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 266264015396 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 266264015397 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266264015398 D-galactonate transporter; Region: 2A0114; TIGR00893 266264015399 putative substrate translocation pore; other site 266264015400 5-dehydro-4-deoxyglucarate dehydratase, also called 5-keto-4-deoxy-glucarate dehydratase (KDGDH); Region: KDGDH; cd00951 266264015401 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 266264015402 putative active site [active] 266264015403 catalytic residue [active] 266264015404 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 266264015405 tetramer interface [polypeptide binding]; other site 266264015406 active site 266264015407 Mg2+/Mn2+ binding site [ion binding]; other site 266264015408 isocitrate lyase; Region: PLN02892 266264015409 Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662 266264015410 NnrU protein; Region: NnrU; pfam07298 266264015411 putative acetyltransferase; Provisional; Region: PRK03624 266264015412 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 266264015413 Coenzyme A binding pocket [chemical binding]; other site 266264015414 Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491 266264015415 non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226 266264015416 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171 266264015417 bacterial (prokaryotic) histone like domain; Region: BHL; smart00411 266264015418 IHF dimer interface [polypeptide binding]; other site 266264015419 IHF - DNA interface [nucleotide binding]; other site 266264015420 Protein of unknown function (DUF962); Region: DUF962; cl01879 266264015421 N-acetyltransferase; Region: Acetyltransf_2; pfam00797 266264015422 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 266264015423 classical (c) SDRs; Region: SDR_c; cd05233 266264015424 NAD(P) binding site [chemical binding]; other site 266264015425 active site 266264015426 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 266264015427 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 266264015428 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 266264015429 acyl-activating enzyme (AAE) consensus motif; other site 266264015430 putative AMP binding site [chemical binding]; other site 266264015431 putative active site [active] 266264015432 putative CoA binding site [chemical binding]; other site 266264015433 Uncharacterized protein conserved in bacteria [Function unknown]; Region: CreA; COG3045 266264015434 CreA protein; Region: CreA; pfam05981 266264015435 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 266264015436 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 266264015437 IHF dimer interface [polypeptide binding]; other site 266264015438 IHF - DNA interface [nucleotide binding]; other site 266264015439 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 266264015440 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 266264015441 Mechanosensitive ion channel; Region: MS_channel; pfam00924 266264015442 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266264015443 bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102 266264015444 putative substrate translocation pore; other site 266264015445 Glucan_BSP_ModH catalyzes the elongation of beta-1,2 polyglucose chains of glucan; Region: Glucan_BSP_ModH; cd04191 266264015446 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 266264015447 Ligand binding site; other site 266264015448 DXD motif; other site 266264015449 glucan biosynthesis protein G; Provisional; Region: mdoG; PRK13274 266264015450 glucan biosynthesis protein D; Provisional; Region: mdoD; PRK13273 266264015451 Surface antigen [Cell envelope biogenesis, outer membrane]; Region: LipA; COG4520 266264015452 3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108 266264015453 3,4-dihydroxy-2-butanone 4-phosphate synthase; Provisional; Region: ribB; PRK03353 266264015454 FMN riboswitch 266264015455 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 266264015456 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 266264015457 non-specific DNA binding site [nucleotide binding]; other site 266264015458 salt bridge; other site 266264015459 sequence-specific DNA binding site [nucleotide binding]; other site 266264015460 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 266264015461 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2841 266264015462 polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707 266264015463 Plasmid maintenance system killer protein; Region: Plasmid_killer; cl01422 266264015464 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 266264015465 sequence-specific DNA binding site [nucleotide binding]; other site 266264015466 salt bridge; other site 266264015467 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 266264015468 Domain of unknown function DUF21; Region: DUF21; pfam01595 266264015469 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 266264015470 Transporter associated domain; Region: CorC_HlyC; smart01091 266264015471 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 266264015472 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 266264015473 Predicted small secreted protein [Function unknown]; Region: COG5510 266264015474 keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718 266264015475 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 266264015476 active site 266264015477 intersubunit interface [polypeptide binding]; other site 266264015478 catalytic residue [active] 266264015479 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 266264015480 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 266264015481 substrate binding site [chemical binding]; other site 266264015482 ATP binding site [chemical binding]; other site 266264015483 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 266264015484 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Bacterial Cryptic D-Serine Dehydratase; Region: PLPDE_III_cryptic_DSD; cd06818 266264015485 dimer interface [polypeptide binding]; other site 266264015486 active site 266264015487 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 266264015488 substrate binding site [chemical binding]; other site 266264015489 catalytic residue [active] 266264015490 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 266264015491 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 266264015492 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 266264015493 putative active site [active] 266264015494 N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653 266264015495 D-aminoacylases (N-acyl-D-Amino acid amidohydrolases) catalyze the hydrolysis of N-acyl-D-amino acids to produce the corresponding D-amino acids, which are used as intermediates in the synthesis of pesticides, bioactive peptides, and antibiotics; Region: D-aminoacylase; cd01297 266264015496 active site 266264015497 putative substrate binding pocket [chemical binding]; other site 266264015498 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 266264015499 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 266264015500 homotrimer interaction site [polypeptide binding]; other site 266264015501 putative active site [active] 266264015502 GntP family permease; Region: GntP_permease; pfam02447 266264015503 fructuronate transporter; Provisional; Region: PRK10034; cl15264 266264015504 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 266264015505 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 266264015506 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 266264015507 Coenzyme A binding pocket [chemical binding]; other site 266264015508 hypothetical protein 266264015509 hypothetical protein 266264015510 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 266264015511 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 266264015512 Walker A/P-loop; other site 266264015513 ATP binding site [chemical binding]; other site 266264015514 Q-loop/lid; other site 266264015515 ABC transporter signature motif; other site 266264015516 Walker B; other site 266264015517 D-loop; other site 266264015518 H-loop/switch region; other site 266264015519 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 266264015520 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 266264015521 Walker A/P-loop; other site 266264015522 ATP binding site [chemical binding]; other site 266264015523 Q-loop/lid; other site 266264015524 ABC transporter signature motif; other site 266264015525 Walker B; other site 266264015526 D-loop; other site 266264015527 H-loop/switch region; other site 266264015528 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 266264015529 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 266264015530 TM-ABC transporter signature motif; other site 266264015531 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 266264015532 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 266264015533 TM-ABC transporter signature motif; other site 266264015534 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 266264015535 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 266264015536 active site 266264015537 catalytic tetrad [active] 266264015538 TLC ATP/ADP transporter; Region: TLC; cl03940 266264015539 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 266264015540 class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300 266264015541 substrate binding site [chemical binding]; other site 266264015542 catalytic Zn binding site [ion binding]; other site 266264015543 NAD binding site [chemical binding]; other site 266264015544 structural Zn binding site [ion binding]; other site 266264015545 dimer interface [polypeptide binding]; other site 266264015546 S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821 266264015547 S-formylglutathione hydrolase; Region: PLN02442 266264015548 Excalibur calcium-binding domain; Region: Excalibur; pfam05901 266264015549 amidase; Provisional; Region: PRK07486 266264015550 Amidase; Region: Amidase; pfam01425 266264015551 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 266264015552 FMN reductase, MsuE subfamily; Region: FMN_reduc_MsuE; TIGR03566 266264015553 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 266264015554 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 266264015555 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 266264015556 p-hydroxybenzoic acid efflux subunit AaeA; Provisional; Region: PRK10559 266264015557 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 266264015558 HlyD family secretion protein; Region: HlyD_3; pfam13437 266264015559 Protein of unknown function (DUF1656); Region: DUF1656; pfam07869 266264015560 Fusaric acid resistance protein family; Region: FUSC; pfam04632 266264015561 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 266264015562 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 266264015563 MarR family; Region: MarR_2; pfam12802 266264015564 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 266264015565 Rhs element Vgr protein; Region: vgr_GE; TIGR01646 266264015566 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 266264015567 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 266264015568 Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296 266264015569 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4253 266264015570 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 266264015571 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 266264015572 RHS Repeat; Region: RHS_repeat; pfam05593 266264015573 RHS Repeat; Region: RHS_repeat; pfam05593 266264015574 RHS Repeat; Region: RHS_repeat; pfam05593 266264015575 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 266264015576 RHS Repeat; Region: RHS_repeat; pfam05593 266264015577 RHS Repeat; Region: RHS_repeat; pfam05593 266264015578 RHS Repeat; Region: RHS_repeat; pfam05593 266264015579 RHS Repeat; Region: RHS_repeat; pfam05593 266264015580 RHS protein; Region: RHS; pfam03527 266264015581 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 266264015582 hypothetical protein 266264015583 RHS family protein (fragment) 266264015584 PAAR motif; Region: PAAR_motif; pfam05488 266264015585 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 266264015586 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266264015587 NAD(P) binding site [chemical binding]; other site 266264015588 active site 266264015589 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 266264015590 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 266264015591 substrate-cofactor binding pocket; other site 266264015592 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266264015593 catalytic residue [active] 266264015594 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 266264015595 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 266264015596 sequence-specific DNA binding site [nucleotide binding]; other site 266264015597 salt bridge; other site 266264015598 Cupin domain; Region: Cupin_2; pfam07883 266264015599 coproporphyrinogen III oxidase; Provisional; Region: PRK13347 266264015600 Di-haem cytochrome c peroxidase; Region: CCP_MauG; pfam03150 266264015601 Phospholipase C [Cell envelope biogenesis, outer membrane]; Region: PlcC; COG3511 266264015602 acid phosphatase, Burkholderia-type; Region: acid_phos_Burk; TIGR03397 266264015603 benzoate transport; Region: 2A0115; TIGR00895 266264015604 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266264015605 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266264015606 hypothetical protein 266264015607 hypothetical protein 266264015608 hypothetical protein 266264015609 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 266264015610 classical (c) SDRs; Region: SDR_c; cd05233 266264015611 NAD(P) binding site [chemical binding]; other site 266264015612 active site 266264015613 Threonine/homoserine efflux transporter [Amino acid transport and metabolism]; Region: rhtA; COG5006 266264015614 EamA-like transporter family; Region: EamA; pfam00892 266264015615 Predicted transcriptional regulators [Transcription]; Region: COG1733 266264015616 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 266264015617 nitrite extrusion protein (nitrite facilitator); Region: 2A0108; TIGR00886 266264015618 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266264015619 nitrite reductase subunit NirD; Provisional; Region: PRK14989 266264015620 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 266264015621 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 266264015622 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 266264015623 Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529 266264015624 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 266264015625 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 266264015626 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 266264015627 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 266264015628 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 266264015629 [4Fe-4S] binding site [ion binding]; other site 266264015630 molybdopterin cofactor binding site; other site 266264015631 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 266264015632 molybdopterin cofactor binding site; other site 266264015633 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 266264015634 YcaO domain protein; Region: TIGR03549 266264015635 OsmC-like protein; Region: OsmC; pfam02566 266264015636 YcaO-like family; Region: YcaO; pfam02624 266264015637 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964 266264015638 YheO-like PAS domain; Region: PAS_6; pfam08348 266264015639 HTH domain; Region: HTH_22; pfam13309 266264015640 Predicted ornithine cyclodeaminase, mu-crystallin homolog [Amino acid transport and metabolism]; Region: COG2423 266264015641 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 266264015642 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 266264015643 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 266264015644 tetramer interface [polypeptide binding]; other site 266264015645 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266264015646 catalytic residue [active] 266264015647 putative transporter; Provisional; Region: PRK10504 266264015648 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266264015649 putative substrate translocation pore; other site 266264015650 NAD-dependent epimerase/dehydratase family protein; Provisional; Region: PRK11908 266264015651 Arna decarboxylase_like, extended (e) SDRs; Region: Arna_like_SDR_e; cd05257 266264015652 NAD binding site [chemical binding]; other site 266264015653 substrate binding site [chemical binding]; other site 266264015654 active site 266264015655 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 266264015656 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 266264015657 DNA-binding transcriptional regulator BasR; Provisional; Region: PRK10643 266264015658 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266264015659 active site 266264015660 phosphorylation site [posttranslational modification] 266264015661 intermolecular recognition site; other site 266264015662 dimerization interface [polypeptide binding]; other site 266264015663 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 266264015664 DNA binding site [nucleotide binding] 266264015665 sensor protein QseC; Provisional; Region: PRK10337 266264015666 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 266264015667 dimer interface [polypeptide binding]; other site 266264015668 phosphorylation site [posttranslational modification] 266264015669 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266264015670 ATP binding site [chemical binding]; other site 266264015671 Mg2+ binding site [ion binding]; other site 266264015672 G-X-G motif; other site 266264015673 Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059 266264015674 chromate transporter, chromate ion transporter (CHR) family; Region: 2A51; TIGR00937 266264015675 Chromate transporter; Region: Chromate_transp; pfam02417 266264015676 Protein of unknown function (DUF2459); Region: DUF2459; pfam09601 266264015677 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 266264015678 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 266264015679 trimer interface [polypeptide binding]; other site 266264015680 eyelet of channel; other site 266264015681 Transglycosylase; Region: Transgly; pfam00912 266264015682 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 266264015683 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 266264015684 Protein of unknown function (DUF1501); Region: DUF1501; pfam07394 266264015685 Protein of unknown function (DUF1800); Region: DUF1800; pfam08811 266264015686 catabolite control protein A; Region: ccpA; TIGR01481 266264015687 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 266264015688 DNA binding site [nucleotide binding] 266264015689 domain linker motif; other site 266264015690 Ligand-binding domain of putative DNA transcription repressors highly similar to that of the repressor specific for gluconate (GntR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR_like_2; cd06282 266264015691 putative dimerization interface [polypeptide binding]; other site 266264015692 putative ligand binding site [chemical binding]; other site 266264015693 2-aminoethylphosphonate ABC transporter, periplasmic 2-aminoethylphosphonate binding protein; Region: PhnS; TIGR03227 266264015694 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 266264015695 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 266264015696 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266264015697 dimer interface [polypeptide binding]; other site 266264015698 conserved gate region; other site 266264015699 putative PBP binding loops; other site 266264015700 ABC-ATPase subunit interface; other site 266264015701 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 266264015702 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266264015703 dimer interface [polypeptide binding]; other site 266264015704 conserved gate region; other site 266264015705 putative PBP binding loops; other site 266264015706 ABC-ATPase subunit interface; other site 266264015707 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 266264015708 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 266264015709 Walker A/P-loop; other site 266264015710 ATP binding site [chemical binding]; other site 266264015711 Q-loop/lid; other site 266264015712 ABC transporter signature motif; other site 266264015713 Walker B; other site 266264015714 D-loop; other site 266264015715 H-loop/switch region; other site 266264015716 TOBE domain; Region: TOBE_2; pfam08402 266264015717 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 266264015718 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 266264015719 active site 266264015720 metal binding site [ion binding]; metal-binding site 266264015721 hexamer interface [polypeptide binding]; other site 266264015722 conserved hypothetical protein 266264015723 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 266264015724 aspartate-alanine antiporter; Region: Asp_Ala_antiprt; TIGR03802 266264015725 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 266264015726 TrkA-C domain; Region: TrkA_C; pfam02080 266264015727 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 266264015728 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 266264015729 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 266264015730 PhnA protein; Region: PhnA; pfam03831 266264015731 EamA-like transporter family; Region: EamA; pfam00892 266264015732 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 266264015733 EamA-like transporter family; Region: EamA; pfam00892 266264015734 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266264015735 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266264015736 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 266264015737 putative effector binding pocket; other site 266264015738 dimerization interface [polypeptide binding]; other site 266264015739 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 266264015740 CoA-transferase family III; Region: CoA_transf_3; pfam02515 266264015741 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 266264015742 Quinone oxidoreductase (QOR); Region: QOR1; cd08241 266264015743 NAD(P) binding site [chemical binding]; other site 266264015744 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 266264015745 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 266264015746 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266264015747 active site 266264015748 phosphorylation site [posttranslational modification] 266264015749 intermolecular recognition site; other site 266264015750 dimerization interface [polypeptide binding]; other site 266264015751 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 266264015752 DNA binding residues [nucleotide binding] 266264015753 dimerization interface [polypeptide binding]; other site 266264015754 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 266264015755 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 266264015756 dimer interface [polypeptide binding]; other site 266264015757 phosphorylation site [posttranslational modification] 266264015758 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266264015759 ATP binding site [chemical binding]; other site 266264015760 Mg2+ binding site [ion binding]; other site 266264015761 G-X-G motif; other site 266264015762 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 266264015763 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266264015764 active site 266264015765 phosphorylation site [posttranslational modification] 266264015766 intermolecular recognition site; other site 266264015767 dimerization interface [polypeptide binding]; other site 266264015768 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 266264015769 Pseudomonas fluorescens 4-hydroxymuconic semialdehyde dehydrogenase-like; Region: ALDH_HMSADH_HapE; cd07115 266264015770 NAD(P) binding site [chemical binding]; other site 266264015771 catalytic residues [active] 266264015772 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2841 266264015773 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 266264015774 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 266264015775 active site 266264015776 FMN binding site [chemical binding]; other site 266264015777 substrate binding site [chemical binding]; other site 266264015778 homotetramer interface [polypeptide binding]; other site 266264015779 catalytic residue [active] 266264015780 Protein related to penicillin acylase [General function prediction only]; Region: COG2366 266264015781 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 266264015782 Cephalosporin acylase (CA) belongs to a family of beta-lactam acylases that includes penicillin G acylase (PGA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_CA; cd01936 266264015783 active site 266264015784 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 266264015785 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 266264015786 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 266264015787 Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992 266264015788 Predicted membrane protein (DUF2127); Region: DUF2127; pfam09900 266264015789 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 266264015790 AcrB/AcrD/AcrF family; Region: ACR_tran; pfam00873 266264015791 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 266264015792 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 266264015793 HlyD family secretion protein; Region: HlyD_3; pfam13437 266264015794 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 266264015795 hypothetical protein 266264015796 transcriptional regulator; Provisional; Region: PRK10632 266264015797 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266264015798 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 266264015799 putative effector binding pocket; other site 266264015800 putative dimerization interface [polypeptide binding]; other site 266264015801 glutamate carboxypeptidase; Reviewed; Region: PRK06133 266264015802 M20 Peptidase Glutamate carboxypeptidase, a periplasmic enzyme; Region: M20_CPDG2; cd03885 266264015803 metal binding site [ion binding]; metal-binding site 266264015804 dimer interface [polypeptide binding]; other site 266264015805 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 266264015806 AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136 266264015807 conserved cys residue [active] 266264015808 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 266264015809 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 266264015810 BON domain; Region: BON; cl02771 266264015811 Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823 266264015812 BON domain; Region: BON; cl02771 266264015813 BON domain; Region: BON; pfam04972 266264015814 Uncharacterized ACR, COG2135; Region: DUF159; pfam02586 266264015815 Ca2+/H+ antiporter [Inorganic ion transport and metabolism]; Region: ChaA; COG0387 266264015816 Ca2+/H+ antiporter [Inorganic ion transport and metabolism]; Region: ChaA; COG0387 266264015817 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 266264015818 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 266264015819 muconolactone delta-isomerase; Region: muco_delta; TIGR03221 266264015820 Muconate Lactonizing Enzyme (MLE), an homooctameric enzyme, catalyses the conversion of cis,cis-muconate (CCM) to muconolactone (ML) in the catechol branch of the beta-ketoadipate pathway. This pathway is used in soil microbes to breakdown lignin-derived...; Region: MLE; cd03318 266264015821 muconate and chloromuconate cycloisomerases; Region: mucon_cyclo; TIGR02534 266264015822 octamer interface [polypeptide binding]; other site 266264015823 active site 266264015824 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 266264015825 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266264015826 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 266264015827 dimerization interface [polypeptide binding]; other site 266264015828 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 266264015829 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266264015830 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in benzoate catabolism; contains the type 2 periplasmic binding fold; Region: PBP2_BenM_CatM_CatR; cd08445 266264015831 dimerizarion interface [polypeptide binding]; other site 266264015832 CrgA pocket; other site 266264015833 substrate binding pocket [chemical binding]; other site 266264015834 catechol 1,2-dioxygenase, proteobacterial; Region: catechol_proteo; TIGR02439 266264015835 Catechol 1,2 dioxygenase (1,2-CTD) catalyzes an intradiol cleavage reaction of catechol to form cis,cis-muconate. 1,2-CTDs is homodimers with one catalytic non-heme ferric ion per monomer. They belong to the aromatic dioxygenase family, a family of...; Region: 1,2-CTD; cd03460 266264015836 dimer interface [polypeptide binding]; other site 266264015837 active site 266264015838 benzoate 1,2-dioxygenase, large subunit; Region: benzo_1_2_benA; TIGR03229 266264015839 Rieske non-heme iron oxygenase (RO) family, 2-Halobenzoate 1,2-dioxygenase (HBDO) subfamily, N-terminal Rieske domain of the oxygenase alpha subunit; ROs comprise a large class of aromatic ring-hydroxylating dioxygenases that enable microorganisms to...; Region: Rieske_RO_Alpha_HBDO; cd03542 266264015840 C-terminal catalytic domain of the oxygenase alpha subunit of Pseudomonas resinovorans strain CA10 anthranilate 1,2-dioxygenase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_AntDO-like; cd08879 266264015841 putative alpha subunit interface [polypeptide binding]; other site 266264015842 putative active site [active] 266264015843 putative substrate binding site [chemical binding]; other site 266264015844 Fe binding site [ion binding]; other site 266264015845 Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667 266264015846 inter-subunit interface; other site 266264015847 anthranilate dioxygenase reductase; Provisional; Region: antC; PRK11872 266264015848 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 266264015849 catalytic loop [active] 266264015850 iron binding site [ion binding]; other site 266264015851 Benzoate dioxygenase reductase (BenDO) FAD/NAD binding domain. Oxygenases oxidize hydrocarbons using dioxygen as the oxidant. As a Class I bacterial dioxygenases, benzoate dioxygenase like proteins combine an [2Fe-2S] cluster containing N-terminal...; Region: BenDO_FAD_NAD; cd06209 266264015852 FAD binding pocket [chemical binding]; other site 266264015853 FAD binding motif [chemical binding]; other site 266264015854 phosphate binding motif [ion binding]; other site 266264015855 beta-alpha-beta structure motif; other site 266264015856 NAD binding pocket [chemical binding]; other site 266264015857 1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase; Provisional; Region: benD; PRK12823 266264015858 1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase (DHB DH)-like, classical (c) SDR; Region: DHB_DH-like_SDR_c; cd08937 266264015859 putative NAD(P) binding site [chemical binding]; other site 266264015860 active site 266264015861 OpgC protein; Region: OpgC_C; pfam10129 266264015862 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 266264015863 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 266264015864 dihydrolipoamide dehydrogenase; Validated; Region: PRK06292 266264015865 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 266264015866 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 266264015867 Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013 266264015868 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 266264015869 catalytic triad [active] 266264015870 dimer interface [polypeptide binding]; other site 266264015871 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 266264015872 hypothetical protein; Provisional; Region: PRK06156 266264015873 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 266264015874 active site 266264015875 metal binding site [ion binding]; metal-binding site 266264015876 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 266264015877 sulfite:cytochrome c oxidoreductase subunit A (SorA), molybdopterin binding domain. SorA is involved in oxidation of sulfur compounds during chemolithothrophic growth. Together with SorB, a small c-type heme containing subunit, it forms a hetrodimer. It; Region: bact_SorA_Moco; cd02114 266264015878 Moco binding site; other site 266264015879 metal coordination site [ion binding]; other site 266264015880 putative dimerization interface [polypeptide binding]; other site 266264015881 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 266264015882 Cytochrome c; Region: Cytochrom_C; cl11414 266264015883 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3558 266264015884 SnoaL-like domain; Region: SnoaL_2; pfam12680 266264015885 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 266264015886 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 266264015887 ligand binding site [chemical binding]; other site 266264015888 flexible hinge region; other site 266264015889 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 266264015890 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 266264015891 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 266264015892 succinate CoA transferase; Region: YgfH_subfam; TIGR03458 266264015893 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 266264015894 Predicted ATPase [General function prediction only]; Region: COG3910 266264015895 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 266264015896 Walker A/P-loop; other site 266264015897 ATP binding site [chemical binding]; other site 266264015898 Q-loop/lid; other site 266264015899 ABC transporter signature motif; other site 266264015900 Walker B; other site 266264015901 D-loop; other site 266264015902 H-loop/switch region; other site 266264015903 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 266264015904 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209 266264015905 active site 266264015906 nucleophile elbow; other site 266264015907 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 266264015908 non-specific DNA binding site [nucleotide binding]; other site 266264015909 salt bridge; other site 266264015910 sequence-specific DNA binding site [nucleotide binding]; other site 266264015911 HipA N-terminal domain; Region: Couple_hipA; cl11853 266264015912 Toxin module HipA, protein kinase of phosphatidylinositol 3/4-kinase superfamily [General function prediction only]; Region: HipA; COG3550 266264015913 HipA-like N-terminal domain; Region: HipA_N; pfam07805 266264015914 HipA-like C-terminal domain; Region: HipA_C; pfam07804 266264015915 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 266264015916 classical (c) SDRs; Region: SDR_c; cd05233 266264015917 NAD(P) binding site [chemical binding]; other site 266264015918 active site 266264015919 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 266264015920 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 266264015921 Major Facilitator Superfamily; Region: MFS_1; pfam07690 266264015922 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266264015923 putative substrate translocation pore; other site 266264015924 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266264015925 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266264015926 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_2; cd08427 266264015927 putative dimerization interface [polypeptide binding]; other site 266264015928 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 266264015929 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_18; cd08357 266264015930 putative metal binding site [ion binding]; other site 266264015931 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 266264015932 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 266264015933 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 266264015934 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 266264015935 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 266264015936 putative catalytic site [active] 266264015937 putative phosphate binding site [ion binding]; other site 266264015938 active site 266264015939 metal binding site A [ion binding]; metal-binding site 266264015940 DNA binding site [nucleotide binding] 266264015941 putative AP binding site [nucleotide binding]; other site 266264015942 putative metal binding site B [ion binding]; other site 266264015943 NosL; Region: NosL; cl01769 266264015944 NosL; Region: NosL; pfam05573 266264015945 ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277 266264015946 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 266264015947 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 266264015948 Walker A/P-loop; other site 266264015949 ATP binding site [chemical binding]; other site 266264015950 Q-loop/lid; other site 266264015951 ABC transporter signature motif; other site 266264015952 Walker B; other site 266264015953 D-loop; other site 266264015954 H-loop/switch region; other site 266264015955 Nitrous oxidase accessory protein [Inorganic ion transport and metabolism]; Region: NosD; COG3420 266264015956 parallel beta-helix repeat (two copies); Region: para_beta_helix; TIGR03804 266264015957 Regulator of nitric oxide reductase transcription [Transcription]; Region: NosR; COG3901 266264015958 ferredoxin-type protein, NapH/MauN family; Region: napH_; TIGR02163 266264015959 4Fe-4S binding domain; Region: Fer4_5; pfam12801 266264015960 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 266264015961 nitrous-oxide reductase; Validated; Region: PRK02888 266264015962 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 266264015963 Cytochrome c5 [Energy production and conversion]; Region: CycB; COG3245 266264015964 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 266264015965 ApbE family; Region: ApbE; pfam02424 266264015966 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 266264015967 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; Region: LPLAT_LCLAT1-like; cd07990 266264015968 putative acyl-acceptor binding pocket; other site 266264015969 DGC domain; Region: DGC; pfam08859 266264015970 Uncharacterized conserved protein (DUF2249); Region: DUF2249; cl17719 266264015971 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 266264015972 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 266264015973 catalytic residues [active] 266264015974 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 266264015975 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 266264015976 putative DNA binding site [nucleotide binding]; other site 266264015977 putative Zn2+ binding site [ion binding]; other site 266264015978 AsnC family; Region: AsnC_trans_reg; pfam01037 266264015979 4-hydroxyphenylpyruvate dioxygenase; Region: 4HPPD; TIGR01263 266264015980 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 266264015981 dimer interface [polypeptide binding]; other site 266264015982 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 266264015983 active site 266264015984 Fe binding site [ion binding]; other site 266264015985 aromatic amino acid transporter; Provisional; Region: PRK10238 266264015986 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 266264015987 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 266264015988 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266264015989 homodimer interface [polypeptide binding]; other site 266264015990 catalytic residue [active] 266264015991 lysine transporter; Provisional; Region: PRK10836 266264015992 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 266264015993 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 266264015994 C-terminal domain interface [polypeptide binding]; other site 266264015995 GSH binding site (G-site) [chemical binding]; other site 266264015996 dimer interface [polypeptide binding]; other site 266264015997 C-terminal, alpha helical domain of Ure2p and related Glutathione S-transferase-like proteins; Region: GST_C_Ure2p_like; cd03178 266264015998 dimer interface [polypeptide binding]; other site 266264015999 N-terminal domain interface [polypeptide binding]; other site 266264016000 Transcriptional regulator [Transcription]; Region: IclR; COG1414 266264016001 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 266264016002 Bacterial transcriptional regulator; Region: IclR; pfam01614 266264016003 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 266264016004 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 266264016005 Cytochrome P450; Region: p450; cl12078 266264016006 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 266264016007 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 266264016008 FMN-binding pocket [chemical binding]; other site 266264016009 flavin binding motif; other site 266264016010 phosphate binding motif [ion binding]; other site 266264016011 beta-alpha-beta structure motif; other site 266264016012 NAD binding pocket [chemical binding]; other site 266264016013 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 266264016014 catalytic loop [active] 266264016015 iron binding site [ion binding]; other site 266264016016 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 266264016017 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 266264016018 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266264016019 active site 266264016020 phosphorylation site [posttranslational modification] 266264016021 intermolecular recognition site; other site 266264016022 dimerization interface [polypeptide binding]; other site 266264016023 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 266264016024 H-NS histone family; Region: Histone_HNS; pfam00816 266264016025 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 266264016026 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 266264016027 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 266264016028 SCP-2 sterol transfer family; Region: SCP2; cl01225 266264016029 putative protease; Provisional; Region: PRK15447 266264016030 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 266264016031 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 266264016032 Peptidase family U32; Region: Peptidase_U32; pfam01136 266264016033 Transcriptional regulator [Transcription]; Region: IclR; COG1414 266264016034 IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339 266264016035 Bacterial transcriptional regulator; Region: IclR; pfam01614 266264016036 succinic semialdehyde dehydrogenase; Region: PLN02278 266264016037 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 266264016038 tetramerization interface [polypeptide binding]; other site 266264016039 NAD(P) binding site [chemical binding]; other site 266264016040 catalytic residues [active] 266264016041 5-hydroxyvalerate dehydrogenase (HVD) catalyzes the oxidation of 5-hydroxyvalerate to 5-oxovalerate with NAD+ as cofactor; Region: HVD; cd08193 266264016042 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 266264016043 putative active site [active] 266264016044 metal binding site [ion binding]; metal-binding site 266264016045 BON domain; Region: BON; cl02771 266264016046 PRC-barrel domain; Region: PRC; pfam05239 266264016047 Citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CCL cleaves citryl-CoA (CiCoA) to acetyl-CoA (AcCoA) and oxaloacetate (OAA); Region: CCL_ACL-C; cd06100 266264016048 active site 266264016049 oxalacetate binding site [chemical binding]; other site 266264016050 citrylCoA binding site [chemical binding]; other site 266264016051 coenzyme A binding site [chemical binding]; other site 266264016052 catalytic triad [active] 266264016053 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 266264016054 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 266264016055 classical (c) SDRs; Region: SDR_c; cd05233 266264016056 NAD(P) binding site [chemical binding]; other site 266264016057 active site 266264016058 acyl-CoA synthetase; Validated; Region: PRK06188 266264016059 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 266264016060 acyl-activating enzyme (AAE) consensus motif; other site 266264016061 putative AMP binding site [chemical binding]; other site 266264016062 putative active site [active] 266264016063 putative CoA binding site [chemical binding]; other site 266264016064 Transcriptional regulators [Transcription]; Region: PurR; COG1609 266264016065 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 266264016066 DNA binding site [nucleotide binding] 266264016067 domain linker motif; other site 266264016068 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_5; cd06281 266264016069 putative dimerization interface [polypeptide binding]; other site 266264016070 putative ligand binding site [chemical binding]; other site 266264016071 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 266264016072 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 266264016073 classical (c) SDRs; Region: SDR_c; cd05233 266264016074 NAD(P) binding site [chemical binding]; other site 266264016075 active site 266264016076 Putative cyclase; Region: Cyclase; cl00814 266264016077 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 266264016078 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266264016079 DNA-binding site [nucleotide binding]; DNA binding site 266264016080 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 266264016081 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266264016082 homodimer interface [polypeptide binding]; other site 266264016083 catalytic residue [active] 266264016084 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 266264016085 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 266264016086 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 266264016087 Serine hydrolase; Region: Ser_hydrolase; cl17834 266264016088 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 266264016089 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 266264016090 PapC N-terminal domain; Region: PapC_N; pfam13954 266264016091 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 266264016092 PapC C-terminal domain; Region: PapC_C; pfam13953 266264016093 putative chaperone protein EcpD; Provisional; Region: PRK09926 266264016094 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 266264016095 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 266264016096 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 266264016097 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 266264016098 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 266264016099 dimer interface [polypeptide binding]; other site 266264016100 phosphorylation site [posttranslational modification] 266264016101 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266264016102 ATP binding site [chemical binding]; other site 266264016103 Mg2+ binding site [ion binding]; other site 266264016104 G-X-G motif; other site 266264016105 Response regulator receiver domain; Region: Response_reg; pfam00072 266264016106 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266264016107 active site 266264016108 phosphorylation site [posttranslational modification] 266264016109 intermolecular recognition site; other site 266264016110 dimerization interface [polypeptide binding]; other site 266264016111 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 266264016112 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 266264016113 DNA binding residues [nucleotide binding] 266264016114 dimerization interface [polypeptide binding]; other site 266264016115 hypothetical protein 266264016116 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 266264016117 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266264016118 active site 266264016119 phosphorylation site [posttranslational modification] 266264016120 intermolecular recognition site; other site 266264016121 dimerization interface [polypeptide binding]; other site 266264016122 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 266264016123 DNA binding residues [nucleotide binding] 266264016124 dimerization interface [polypeptide binding]; other site 266264016125 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 266264016126 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 266264016127 substrate binding pocket [chemical binding]; other site 266264016128 membrane-bound complex binding site; other site 266264016129 hinge residues; other site 266264016130 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 266264016131 dimer interface [polypeptide binding]; other site 266264016132 phosphorylation site [posttranslational modification] 266264016133 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266264016134 ATP binding site [chemical binding]; other site 266264016135 Mg2+ binding site [ion binding]; other site 266264016136 G-X-G motif; other site 266264016137 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 266264016138 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266264016139 active site 266264016140 phosphorylation site [posttranslational modification] 266264016141 intermolecular recognition site; other site 266264016142 dimerization interface [polypeptide binding]; other site 266264016143 hypothetical protein 266264016144 Di-haem cytochrome c peroxidase; Region: CCP_MauG; pfam03150 266264016145 Predicted thiol oxidoreductase [Energy production and conversion]; Region: COG3488 266264016146 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 266264016147 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 266264016148 CoA-transferase family III; Region: CoA_transf_3; pfam02515 266264016149 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 266264016150 CoA-transferase family III; Region: CoA_transf_3; pfam02515 266264016151 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 266264016152 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 266264016153 ATP-grasp domain; Region: ATP-grasp_4; cl17255 266264016154 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785 266264016155 Biotin carboxyl carrier protein [Lipid metabolism]; Region: AccB; COG0511 266264016156 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 266264016157 carboxyltransferase (CT) interaction site; other site 266264016158 biotinylation site [posttranslational modification]; other site 266264016159 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 266264016160 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 266264016161 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 266264016162 Integrase core domain; Region: rve; pfam00665 266264016163 Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299 266264016164 Bacterial TniB protein; Region: TniB; pfam05621 266264016165 TniQ; Region: TniQ; pfam06527 266264016166 multiple promoter invertase; Provisional; Region: mpi; PRK13413 266264016167 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 266264016168 catalytic residues [active] 266264016169 catalytic nucleophile [active] 266264016170 Presynaptic Site I dimer interface [polypeptide binding]; other site 266264016171 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 266264016172 Synaptic Flat tetramer interface [polypeptide binding]; other site 266264016173 Synaptic Site I dimer interface [polypeptide binding]; other site 266264016174 DNA binding site [nucleotide binding] 266264016175 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 266264016176 DNA-binding interface [nucleotide binding]; DNA binding site 266264016177 Predicted membrane protein [Function unknown]; Region: COG2510 266264016178 sensor protein QseC; Provisional; Region: PRK10337 266264016179 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 266264016180 dimer interface [polypeptide binding]; other site 266264016181 phosphorylation site [posttranslational modification] 266264016182 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266264016183 ATP binding site [chemical binding]; other site 266264016184 Mg2+ binding site [ion binding]; other site 266264016185 G-X-G motif; other site 266264016186 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 266264016187 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266264016188 active site 266264016189 phosphorylation site [posttranslational modification] 266264016190 intermolecular recognition site; other site 266264016191 dimerization interface [polypeptide binding]; other site 266264016192 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 266264016193 DNA binding site [nucleotide binding] 266264016194 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 266264016195 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 266264016196 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 266264016197 Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4705 266264016198 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 266264016199 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 266264016200 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 266264016201 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 266264016202 PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as bacitracin transport permeases, as it was suspected that they form the permease component of an ABC transporter system. It was shown, however, that BcrC from...; Region: PAP2_BcrC_like; cd03385 266264016203 active site 266264016204 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 266264016205 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 266264016206 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 266264016207 EamA-like transporter family; Region: EamA; pfam00892 266264016208 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 266264016209 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 266264016210 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266264016211 active site 266264016212 phosphorylation site [posttranslational modification] 266264016213 intermolecular recognition site; other site 266264016214 dimerization interface [polypeptide binding]; other site 266264016215 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 266264016216 DNA binding residues [nucleotide binding] 266264016217 dimerization interface [polypeptide binding]; other site 266264016218 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 266264016219 Histidine kinase; Region: HisKA_3; pfam07730 266264016220 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266264016221 ATP binding site [chemical binding]; other site 266264016222 Mg2+ binding site [ion binding]; other site 266264016223 G-X-G motif; other site 266264016224 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 266264016225 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 266264016226 Predicted extracellular nuclease [General function prediction only]; Region: COG2374 266264016227 YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486 266264016228 generic binding surface I; other site 266264016229 generic binding surface II; other site 266264016230 Mycoplasma pulmonis MnuA nuclease-like; Region: MnuA_DNase1-like; cd10283 266264016231 putative active site [active] 266264016232 putative catalytic site [active] 266264016233 putative Mg binding site IVb [ion binding]; other site 266264016234 putative phosphate binding site [ion binding]; other site 266264016235 putative DNA binding site [nucleotide binding]; other site 266264016236 putative Mg binding site IVa [ion binding]; other site 266264016237 rhomboid family GlyGly-CTERM serine protease; Region: rhom_GG_sort; TIGR03902 266264016238 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 266264016239 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 266264016240 trimer interface [polypeptide binding]; other site 266264016241 eyelet of channel; other site 266264016242 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 266264016243 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266264016244 putative substrate translocation pore; other site 266264016245 benzoate transport; Region: 2A0115; TIGR00895 266264016246 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266264016247 putative substrate translocation pore; other site 266264016248 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 266264016249 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 266264016250 eyelet of channel; other site 266264016251 trimer interface [polypeptide binding]; other site 266264016252 Glutathione-dependent formaldehyde-activating enzyme; Region: GFA; pfam04828 266264016253 potential protein location (hypothetical protein) that overlaps protein (conserved hypothetical protein) 266264016254 Protein of unknown function (DUF3455); Region: DUF3455; pfam11937 266264016255 2-hydroxycarboxylate transporter family; Region: 2HCT; pfam03390 266264016256 Uncharacterized conserved protein [Function unknown]; Region: COG5361 266264016257 Protein of unknown function (DUF1254); Region: DUF1254; pfam06863 266264016258 Protein of unknown function (DUF1214); Region: DUF1214; pfam06742 266264016259 Uncharacterized conserved protein [Function unknown]; Region: COG5361 266264016260 Protein of unknown function (DUF1254); Region: DUF1254; pfam06863 266264016261 Protein of unknown function (DUF1214); Region: DUF1214; cl08447 266264016262 H+ Antiporter protein; Region: 2A0121; TIGR00900 266264016263 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266264016264 putative substrate translocation pore; other site 266264016265 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 266264016266 MarR family; Region: MarR_2; pfam12802 266264016267 Uncharacterized conserved protein [Function unknown]; Region: COG1359 266264016268 Isochorismatase family; Region: Isochorismatase; pfam00857 266264016269 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 266264016270 catalytic triad [active] 266264016271 conserved cis-peptide bond; other site 266264016272 V-type ATP synthase subunit E; Provisional; Region: PRK02292 266264016273 CsbD-like; Region: CsbD; cl17424 266264016274 Alanine dehydrogenase/PNT, C-terminal domain; Region: AlaDh_PNT_C; smart01002 266264016275 uncharacterized flavoprotein, PP_4765 family; Region: flavo_PP4765; TIGR03862 266264016276 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4430 266264016277 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 266264016278 mercuric reductase; Validated; Region: PRK06370 266264016279 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 266264016280 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 266264016281 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 266264016282 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 266264016283 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 266264016284 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 266264016285 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 266264016286 active site 266264016287 catalytic tetrad [active] 266264016288 choline dehydrogenase; Validated; Region: PRK02106 266264016289 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 266264016290 Protein of unknown function (DUF1481); Region: DUF1481; pfam07356 266264016291 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like; Region: ALDH_CddD_SSP0762; cd07138 266264016292 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 266264016293 NAD binding site [chemical binding]; other site 266264016294 catalytic residues [active] 266264016295 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 266264016296 CoA-transferase family III; Region: CoA_transf_3; pfam02515 266264016297 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 266264016298 CoenzymeA binding site [chemical binding]; other site 266264016299 subunit interaction site [polypeptide binding]; other site 266264016300 PHB binding site; other site 266264016301 ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909 266264016302 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 266264016303 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 266264016304 DNA binding residues [nucleotide binding] 266264016305 dimerization interface [polypeptide binding]; other site 266264016306 ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909 266264016307 AAA ATPase domain; Region: AAA_16; pfam13191 266264016308 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 266264016309 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 266264016310 DNA binding residues [nucleotide binding] 266264016311 dimerization interface [polypeptide binding]; other site 266264016312 feruloyl-CoA synthase; Reviewed; Region: PRK08180 266264016313 Feruloyl-CoA synthetase (FCS); Region: FCS; cd05921 266264016314 acyl-activating enzyme (AAE) consensus motif; other site 266264016315 putative AMP binding site [chemical binding]; other site 266264016316 putative active site [active] 266264016317 putative CoA binding site [chemical binding]; other site 266264016318 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 266264016319 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 266264016320 active site 266264016321 lipid-transfer protein; Provisional; Region: PRK08256 266264016322 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 266264016323 active site 266264016324 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 266264016325 active site 266264016326 catalytic site [active] 266264016327 SAV4209_like. Similar in sequence to the Streptomyces avermitilis SAV4209 protein, with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid...; Region: SAV4209_like; cd03453 266264016328 active site 266264016329 catalytic site [active] 266264016330 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 266264016331 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266264016332 NAD(P) binding site [chemical binding]; other site 266264016333 active site 266264016334 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 266264016335 active site 266264016336 catalytic triad [active] 266264016337 oxyanion hole [active] 266264016338 Outer membrane efflux protein; Region: OEP; pfam02321 266264016339 copper/silver efflux system membrane fusion protein CusB; Provisional; Region: PRK09783 266264016340 HlyD family secretion protein; Region: HlyD_3; pfam13437 266264016341 Copper binding periplasmic protein CusF; Region: CusF_Ec; pfam11604 266264016342 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 266264016343 Copper binding periplasmic protein CusF; Region: CusF_Ec; pfam11604 266264016344 Uncharacterized protein conserved in bacteria (DUF2188); Region: DUF2188; pfam09954 266264016345 potential protein location (hypothetical protein) that overlaps protein (conserved hypothetical protein) 266264016346 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 266264016347 CoenzymeA binding site [chemical binding]; other site 266264016348 subunit interaction site [polypeptide binding]; other site 266264016349 PHB binding site; other site 266264016350 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 266264016351 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 266264016352 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 266264016353 PYR/PP interface [polypeptide binding]; other site 266264016354 dimer interface [polypeptide binding]; other site 266264016355 TPP binding site [chemical binding]; other site 266264016356 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 266264016357 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 266264016358 TPP-binding site [chemical binding]; other site 266264016359 Transcriptional regulators [Transcription]; Region: GntR; COG1802 266264016360 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266264016361 DNA-binding site [nucleotide binding]; DNA binding site 266264016362 FCD domain; Region: FCD; pfam07729 266264016363 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 266264016364 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 266264016365 metal binding site [ion binding]; metal-binding site 266264016366 active site 266264016367 I-site; other site 266264016368 Phasin protein; Region: Phasin_2; pfam09361 266264016369 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 266264016370 Mechanosensitive ion channel; Region: MS_channel; pfam00924 266264016371 Formimidoylglutamase or HutE; Region: Formimidoylglutamase; cd09988 266264016372 putative active site [active] 266264016373 putative metal binding site [ion binding]; other site 266264016374 putative proline-specific permease; Provisional; Region: proY; PRK10580 266264016375 Spore germination protein; Region: Spore_permease; cl17796 266264016376 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 266264016377 active sites [active] 266264016378 tetramer interface [polypeptide binding]; other site 266264016379 urocanate hydratase; Provisional; Region: PRK05414 266264016380 histidine utilization repressor, proteobacterial; Region: his_ut_repres; TIGR02018 266264016381 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266264016382 DNA-binding site [nucleotide binding]; DNA binding site 266264016383 UTRA domain; Region: UTRA; pfam07702 266264016384 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 266264016385 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 266264016386 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 266264016387 Walker A/P-loop; other site 266264016388 ATP binding site [chemical binding]; other site 266264016389 Q-loop/lid; other site 266264016390 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 266264016391 ABC transporter signature motif; other site 266264016392 Walker B; other site 266264016393 D-loop; other site 266264016394 ABC transporter; Region: ABC_tran_2; pfam12848 266264016395 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 266264016396 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 266264016397 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 266264016398 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 266264016399 active site 266264016400 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 266264016401 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 266264016402 Patatin phospholipase; Region: DUF3734; pfam12536 266264016403 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 266264016404 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 266264016405 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 266264016406 Coenzyme A transferase; Region: CoA_trans; cl17247 266264016407 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 266264016408 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 266264016409 Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl17208 266264016410 catechol 1,2-dioxygenase, proteobacterial; Region: catechol_proteo; TIGR02439 266264016411 active site 266264016412 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 266264016413 Maleylacetate reductase is involved in many aromatic compounds degradation pathways of aerobic microbes; Region: MAR; cd08177 266264016414 active site 266264016415 dimer interface [polypeptide binding]; other site 266264016416 metal binding site [ion binding]; metal-binding site 266264016417 META domain; Region: META; cl01245 266264016418 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_4; cd08897 266264016419 putative hydrophobic ligand binding site [chemical binding]; other site 266264016420 Major Facilitator Superfamily; Region: MFS_1; pfam07690 266264016421 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266264016422 putative substrate translocation pore; other site 266264016423 Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420 266264016424 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 266264016425 Coenzyme A binding pocket [chemical binding]; other site 266264016426 conserved hypothetical protein; partial overlap with helicases 266264016427 O-methyltransferase; Region: Methyltransf_2; pfam00891 266264016428 conserved hypothetical protein; partial overlap 266264016429 methionine synthase; Provisional; Region: PRK01207 266264016430 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 266264016431 substrate binding site [chemical binding]; other site 266264016432 THF binding site; other site 266264016433 zinc-binding site [ion binding]; other site 266264016434 Domain of unknown function (DUF1852); Region: DUF1852; pfam08908 266264016435 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 266264016436 FMN reductase, MsuE subfamily; Region: FMN_reduc_MsuE; TIGR03566 266264016437 conserved hypothetical protein, partial overlap with arylsulfatase 266264016438 conserved hypothetical protein, partial overlap with arylsulfatase 266264016439 Prokaryotic protein of unknown function (DUF849); Region: DUF849; pfam05853 266264016440 Protein of unknown function (DUF3348); Region: DUF3348; pfam11828 266264016441 Domain of unknown function (DUF802); Region: DUF802; pfam05650 266264016442 hypothetical protein; Provisional; Region: PRK09040 266264016443 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 266264016444 ligand binding site [chemical binding]; other site 266264016445 Protein of unknown function (DUF2894); Region: DUF2894; pfam11445 266264016446 Cupin domain; Region: Cupin_2; pfam07883 266264016447 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 266264016448 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 266264016449 non-specific DNA binding site [nucleotide binding]; other site 266264016450 salt bridge; other site 266264016451 sequence-specific DNA binding site [nucleotide binding]; other site 266264016452 Cupin domain; Region: Cupin_2; pfam07883 266264016453 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 266264016454 hydroxyglutarate oxidase; Provisional; Region: PRK11728 266264016455 Uncharacterized conserved protein [Function unknown]; Region: COG5476 266264016456 Protein of unknown function (DUF1485); Region: DUF1485; pfam07364 266264016457 MlrC C-terminus; Region: MlrC_C; pfam07171 266264016458 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 266264016459 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_16; cd08502 266264016460 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 266264016461 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266264016462 dimer interface [polypeptide binding]; other site 266264016463 conserved gate region; other site 266264016464 putative PBP binding loops; other site 266264016465 ABC-ATPase subunit interface; other site 266264016466 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 266264016467 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266264016468 dimer interface [polypeptide binding]; other site 266264016469 conserved gate region; other site 266264016470 putative PBP binding loops; other site 266264016471 ABC-ATPase subunit interface; other site 266264016472 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 266264016473 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 266264016474 Walker A/P-loop; other site 266264016475 ATP binding site [chemical binding]; other site 266264016476 Q-loop/lid; other site 266264016477 ABC transporter signature motif; other site 266264016478 Walker B; other site 266264016479 D-loop; other site 266264016480 H-loop/switch region; other site 266264016481 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 266264016482 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 266264016483 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 266264016484 Walker A/P-loop; other site 266264016485 ATP binding site [chemical binding]; other site 266264016486 Q-loop/lid; other site 266264016487 ABC transporter signature motif; other site 266264016488 Walker B; other site 266264016489 D-loop; other site 266264016490 H-loop/switch region; other site 266264016491 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 266264016492 N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653 266264016493 D-aminoacylases (N-acyl-D-Amino acid amidohydrolases) catalyze the hydrolysis of N-acyl-D-amino acids to produce the corresponding D-amino acids, which are used as intermediates in the synthesis of pesticides, bioactive peptides, and antibiotics; Region: D-aminoacylase; cd01297 266264016494 active site 266264016495 putative substrate binding pocket [chemical binding]; other site 266264016496 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 266264016497 Lipopolysaccharide biosynthesis precursor (fragment) 266264016498 enoyl-CoA hydratase; Provisional; Region: PRK08260 266264016499 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 266264016500 substrate binding site [chemical binding]; other site 266264016501 oxyanion hole (OAH) forming residues; other site 266264016502 trimer interface [polypeptide binding]; other site 266264016503 Malate/L-lactate dehydrogenases [Energy production and conversion]; Region: COG2055 266264016504 Alpha-Ketoglutaric Semialdehyde Dehydrogenase; Region: ALDH_KGSADH; cd07129 266264016505 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 266264016506 dimer interface [polypeptide binding]; other site 266264016507 NADP binding site [chemical binding]; other site 266264016508 catalytic residues [active] 266264016509 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 266264016510 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 266264016511 inhibitor site; inhibition site 266264016512 active site 266264016513 dimer interface [polypeptide binding]; other site 266264016514 catalytic residue [active] 266264016515 metabolite-proton symporter; Region: 2A0106; TIGR00883 266264016516 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266264016517 putative substrate translocation pore; other site 266264016518 Transcriptional regulators [Transcription]; Region: GntR; COG1802 266264016519 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266264016520 DNA-binding site [nucleotide binding]; DNA binding site 266264016521 FCD domain; Region: FCD; pfam07729 266264016522 Transcriptional regulators [Transcription]; Region: GntR; COG1802 266264016523 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266264016524 DNA-binding site [nucleotide binding]; DNA binding site 266264016525 FCD domain; Region: FCD; pfam07729 266264016526 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266264016527 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266264016528 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 266264016529 substrate binding pocket [chemical binding]; other site 266264016530 dimerization interface [polypeptide binding]; other site 266264016531 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 266264016532 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 266264016533 NAD(P) binding site [chemical binding]; other site 266264016534 RibD C-terminal domain; Region: RibD_C; cl17279 266264016535 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 266264016536 bifunctional nicotinamide mononucleotide adenylyltransferase/ADP-ribose pyrophosphatase; Provisional; Region: PRK05379 266264016537 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 266264016538 active site 266264016539 nucleotide binding site [chemical binding]; other site 266264016540 HIGH motif; other site 266264016541 KMSKS motif; other site 266264016542 ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051 266264016543 nudix motif; other site 266264016544 putative nicotinate phosphoribosyltransferase; Provisional; Region: PRK09198 266264016545 pre-B-cell colony-enhancing factor (PBEF)-like. The mammalian members of this group of nicotinate phosphoribosyltransferases (NAPRTases) were originally identified as genes whose expression is upregulated upon activation in lymphoid cells. In general; Region: PBEF_like; cd01569 266264016546 active site 266264016547 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266264016548 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266264016549 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_1; cd08421 266264016550 putative dimerization interface [polypeptide binding]; other site 266264016551 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 266264016552 enoyl-CoA hydratase; Provisional; Region: PRK06688 266264016553 substrate binding site [chemical binding]; other site 266264016554 oxyanion hole (OAH) forming residues; other site 266264016555 trimer interface [polypeptide binding]; other site 266264016556 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 266264016557 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 266264016558 CoA-transferase family III; Region: CoA_transf_3; pfam02515 266264016559 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 266264016560 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 266264016561 substrate binding site [chemical binding]; other site 266264016562 oxyanion hole (OAH) forming residues; other site 266264016563 trimer interface [polypeptide binding]; other site 266264016564 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 266264016565 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 266264016566 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 266264016567 thiolase; Provisional; Region: PRK06158 266264016568 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 266264016569 active site 266264016570 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 266264016571 DUF35 OB-fold domain; Region: DUF35; pfam01796 266264016572 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 266264016573 glutamate dehydrogenase; Provisional; Region: PRK09414 266264016574 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 266264016575 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 266264016576 NAD(P) binding site [chemical binding]; other site 266264016577 LysE type translocator; Region: LysE; cl00565 266264016578 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 266264016579 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 266264016580 active site 266264016581 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 266264016582 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 266264016583 trimer interface [polypeptide binding]; other site 266264016584 eyelet of channel; other site 266264016585 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 266264016586 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 266264016587 Prokaryotic protein of unknown function (DUF849); Region: DUF849; pfam05853 266264016588 TOBE domain; Region: TOBE; cl01440 266264016589 Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585 266264016590 Poly-beta-hydroxybutyrate polymerase N terminal; Region: PHBC_N; pfam12551 266264016591 poly(R)-hydroxyalkanoic acid synthase, class I; Region: PHA_synth_I; TIGR01838 266264016592 Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167 266264016593 acetoacetyl-CoA reductase; Region: AcAcCoA_reduct; TIGR01829 266264016594 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 266264016595 NAD(P) binding site [chemical binding]; other site 266264016596 homotetramer interface [polypeptide binding]; other site 266264016597 homodimer interface [polypeptide binding]; other site 266264016598 active site 266264016599 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2187 266264016600 AAA domain; Region: AAA_33; pfam13671 266264016601 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 266264016602 active site 266264016603 Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763 266264016604 Protein of unknown function (DUF1311); Region: DUF1311; pfam07007 266264016605 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 266264016606 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 266264016607 Walker A motif; other site 266264016608 ATP binding site [chemical binding]; other site 266264016609 Walker B motif; other site 266264016610 arginine finger; other site 266264016611 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 266264016612 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 266264016613 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 266264016614 NAD(P) binding site [chemical binding]; other site 266264016615 catalytic residues [active] 266264016616 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 266264016617 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 266264016618 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266264016619 ATP binding site [chemical binding]; other site 266264016620 Mg2+ binding site [ion binding]; other site 266264016621 G-X-G motif; other site 266264016622 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 266264016623 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266264016624 active site 266264016625 phosphorylation site [posttranslational modification] 266264016626 intermolecular recognition site; other site 266264016627 dimerization interface [polypeptide binding]; other site 266264016628 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 266264016629 DNA binding site [nucleotide binding] 266264016630 Predicted membrane protein [Function unknown]; Region: COG3212 266264016631 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 266264016632 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 266264016633 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 266264016634 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 266264016635 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 266264016636 active site 266264016637 acyl-CoA synthetase; Validated; Region: PRK06188 266264016638 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 266264016639 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 266264016640 acyl-activating enzyme (AAE) consensus motif; other site 266264016641 acyl-activating enzyme (AAE) consensus motif; other site 266264016642 putative AMP binding site [chemical binding]; other site 266264016643 putative active site [active] 266264016644 putative CoA binding site [chemical binding]; other site 266264016645 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266264016646 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266264016647 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 266264016648 dimerization interface [polypeptide binding]; other site 266264016649 Oxygenase domain of the 2OGFeDO superfamily; Region: Tet_JBP; pfam12851 266264016650 anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG2; TIGR02495 266264016651 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 266264016652 FeS/SAM binding site; other site 266264016653 Anaerobic ribonucleoside-triphosphate reductase; Region: NRDD; pfam13597 266264016654 Anaerobic ribonucleoside-triphosphate reductase; Region: NRDD; pfam13597 266264016655 Class III ribonucleotide reductase; Region: RNR_III; cd01675 266264016656 effector binding site; other site 266264016657 active site 266264016658 Zn binding site [ion binding]; other site 266264016659 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 266264016660 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 266264016661 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 266264016662 acyl-activating enzyme (AAE) consensus motif; other site 266264016663 putative AMP binding site [chemical binding]; other site 266264016664 putative active site [active] 266264016665 putative CoA binding site [chemical binding]; other site 266264016666 pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204 266264016667 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 266264016668 active site 266264016669 pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203 266264016670 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 266264016671 active site 266264016672 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 266264016673 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 266264016674 pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204 266264016675 active site 266264016676 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 266264016677 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 266264016678 substrate binding site [chemical binding]; other site 266264016679 oxyanion hole (OAH) forming residues; other site 266264016680 trimer interface [polypeptide binding]; other site 266264016681 NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450 266264016682 putative active site [active] 266264016683 putative catalytic site [active] 266264016684 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 266264016685 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 266264016686 CoA-transferase family III; Region: CoA_transf_3; pfam02515 266264016687 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 266264016688 enoyl-CoA hydratase; Provisional; Region: PRK09245 266264016689 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 266264016690 substrate binding site [chemical binding]; other site 266264016691 oxyanion hole (OAH) forming residues; other site 266264016692 trimer interface [polypeptide binding]; other site 266264016693 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 266264016694 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266264016695 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 266264016696 dimerization interface [polypeptide binding]; other site 266264016697 substrate binding pocket [chemical binding]; other site 266264016698 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 266264016699 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 266264016700 active site 266264016701 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 266264016702 enoyl-CoA hydratase; Provisional; Region: PRK08252 266264016703 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 266264016704 substrate binding site [chemical binding]; other site 266264016705 oxyanion hole (OAH) forming residues; other site 266264016706 trimer interface [polypeptide binding]; other site 266264016707 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266264016708 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 266264016709 NAD(P) binding site [chemical binding]; other site 266264016710 active site 266264016711 acetyl-CoA acetyltransferase; Provisional; Region: PRK07801 266264016712 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 266264016713 dimer interface [polypeptide binding]; other site 266264016714 active site 266264016715 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 266264016716 Transcriptional regulator [Transcription]; Region: IclR; COG1414 266264016717 Bacterial transcriptional regulator; Region: IclR; pfam01614 266264016718 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08276 266264016719 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 266264016720 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 266264016721 acyl-activating enzyme (AAE) consensus motif; other site 266264016722 putative AMP binding site [chemical binding]; other site 266264016723 putative active site [active] 266264016724 acyl-activating enzyme (AAE) consensus motif; other site 266264016725 putative CoA binding site [chemical binding]; other site 266264016726 CoA binding site [chemical binding]; other site 266264016727 putative DNA-binding transcriptional regulator; Provisional; Region: PRK09791 266264016728 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266264016729 The C-terminal substrate binding domain of LysR-type transcriptional regulator TdcA, which is involved in the degradation of L-serine and L-threonine, contains the type 2 periplasmic binding fold; Region: PBP2_TdcA; cd08418 266264016730 putative substrate binding pocket [chemical binding]; other site 266264016731 putative dimerization interface [polypeptide binding]; other site 266264016732 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 266264016733 Alkyl sulfatase and related hydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2015 266264016734 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 266264016735 Uncharacterized conserved protein [Function unknown]; Region: COG5361 266264016736 Protein of unknown function (DUF1254); Region: DUF1254; pfam06863 266264016737 Protein of unknown function (DUF1214); Region: DUF1214; cl08447 266264016738 autotransporter (fragment) 266264016739 potential protein location (hypothetical protein) that overlaps protein (hypothetical protein) 266264016740 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 266264016741 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266264016742 active site 266264016743 phosphorylation site [posttranslational modification] 266264016744 intermolecular recognition site; other site 266264016745 dimerization interface [polypeptide binding]; other site 266264016746 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 266264016747 DNA binding residues [nucleotide binding] 266264016748 dimerization interface [polypeptide binding]; other site 266264016749 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 266264016750 Histidine kinase; Region: HisKA_3; pfam07730 266264016751 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 266264016752 ATP binding site [chemical binding]; other site 266264016753 Mg2+ binding site [ion binding]; other site 266264016754 G-X-G motif; other site 266264016755 High potential iron-sulfur protein; Region: HIPIP; pfam01355 266264016756 AIDA autotransporter-like protein ShdA; Provisional; Region: PRK15319 266264016757 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266264016758 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266264016759 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 266264016760 dimerization interface [polypeptide binding]; other site 266264016761 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_10; cd04667 266264016762 nudix motif; other site 266264016763 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 266264016764 DNA-binding site [nucleotide binding]; DNA binding site 266264016765 RNA-binding motif; other site 266264016766 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 266264016767 rRNA binding site [nucleotide binding]; other site 266264016768 predicted 30S ribosome binding site; other site 266264016769 Uncharacterized protein conserved in bacteria (DUF2188); Region: DUF2188; pfam09954 266264016770 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 266264016771 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 266264016772 CoenzymeA binding site [chemical binding]; other site 266264016773 subunit interaction site [polypeptide binding]; other site 266264016774 PHB binding site; other site 266264016775 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884 266264016776 active site clefts [active] 266264016777 zinc binding site [ion binding]; other site 266264016778 dimer interface [polypeptide binding]; other site 266264016779 Ion channel; Region: Ion_trans_2; pfam07885 266264016780 Putative Ig domain; Region: He_PIG; pfam05345 266264016781 Galactose oxidase, central domain; Region: Kelch_4; pfam13418 266264016782 Kelch domain; Region: Kelch; smart00612 266264016783 Galactose oxidase, central domain; Region: Kelch_4; pfam13418 266264016784 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 266264016785 dimerization interface [polypeptide binding]; other site 266264016786 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262 266264016787 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 266264016788 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 266264016789 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 266264016790 trimer interface [polypeptide binding]; other site 266264016791 eyelet of channel; other site 266264016792 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 266264016793 A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; cl17448 266264016794 Kynureninase [Amino acid transport and metabolism]; Region: COG3844 266264016795 kynureninase; Region: kynureninase; TIGR01814 266264016796 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 266264016797 catalytic residue [active] 266264016798 3-hydroxyanthranilate 3,4-dioxygenase; Provisional; Region: PRK13264 266264016799 pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424 266264016800 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266264016801 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 266264016802 dimerization interface [polypeptide binding]; other site 266264016803 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 266264016804 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 266264016805 trimer interface [polypeptide binding]; other site 266264016806 eyelet of channel; other site 266264016807 Cytochrome c; Region: Cytochrom_C; cl11414 266264016808 Hydroxy(phenyl)pyruvate Reductase, D-isomer-specific 2-hydroxyacid-related dehydrogenase; Region: HPPR; cd12156 266264016809 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 266264016810 putative ligand binding site [chemical binding]; other site 266264016811 NAD binding site [chemical binding]; other site 266264016812 catalytic site [active] 266264016813 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 266264016814 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 266264016815 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 266264016816 C-terminal domain of type I, class II extradiol dioxygenases; catalytic domain; Region: ED_TypeI_classII_C; cd08343 266264016817 active site 266264016818 metal binding site [ion binding]; metal-binding site 266264016819 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 266264016820 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 266264016821 substrate binding pocket [chemical binding]; other site 266264016822 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 266264016823 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 266264016824 inhibitor site; inhibition site 266264016825 active site 266264016826 dimer interface [polypeptide binding]; other site 266264016827 catalytic residue [active] 266264016828 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 266264016829 homotrimer interaction site [polypeptide binding]; other site 266264016830 putative active site [active] 266264016831 Nitroreductase-like family 5. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_5; cd02148 266264016832 putative FMN binding site [chemical binding]; other site 266264016833 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 266264016834 2-hydroxymuconic semialdehyde dehydrogenase; Region: OH_muco_semi_DH; TIGR03216 266264016835 Human aldehyde dehydrogenase family 8 member A1-like; Region: ALDH_F8_HMSADH; cd07093 266264016836 NAD binding site [chemical binding]; other site 266264016837 catalytic residues [active] 266264016838 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 266264016839 acetaldehyde dehydrogenase; Validated; Region: PRK08300 266264016840 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 266264016841 Prokaryotic acetaldehyde dehydrogenase, dimerisation; Region: AcetDehyd-dimer; pfam09290 266264016842 4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase,; Validated; Region: PRK08195 266264016843 4-hydroxy-2-oxovalerate aldolase, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_HOA; cd07943 266264016844 active site 266264016845 catalytic residues [active] 266264016846 metal binding site [ion binding]; metal-binding site 266264016847 DmpG-like communication domain; Region: DmpG_comm; pfam07836 266264016848 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 266264016849 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 266264016850 homotrimer interaction site [polypeptide binding]; other site 266264016851 putative active site [active] 266264016852 Amidohydrolase; Region: Amidohydro_2; pfam04909 266264016853 phosphonate utilization associated transcriptional regulator; Region: phnR_burk; TIGR03338 266264016854 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266264016855 DNA-binding site [nucleotide binding]; DNA binding site 266264016856 FCD domain; Region: FCD; pfam07729 266264016857 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 266264016858 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 266264016859 active site 266264016860 metal binding site [ion binding]; metal-binding site 266264016861 LssY C-terminus; Region: LssY_C; pfam14067 266264016862 LssY C-terminus; Region: LssY_C; pfam14067 266264016863 The SYLF domain (also called DUF500), a novel lipid-binding module; Region: SYLF; cd11524 266264016864 putative amphipathic alpha helix; other site 266264016865 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 266264016866 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266264016867 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 266264016868 dimerization interface [polypeptide binding]; other site 266264016869 substrate binding pocket [chemical binding]; other site 266264016870 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 266264016871 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 266264016872 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 266264016873 metal binding site [ion binding]; metal-binding site 266264016874 putative dimer interface [polypeptide binding]; other site 266264016875 Chromate resistance exported protein; Region: Chrome_Resist; pfam09828 266264016876 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; pfam13557 266264016877 Protein of unknown function (DUF1254); Region: DUF1254; pfam06863 266264016878 Uncharacterized conserved protein [Function unknown]; Region: COG5361 266264016879 Protein of unknown function (DUF1214); Region: DUF1214; pfam06742 266264016880 Uncharacterized conserved protein [Function unknown]; Region: COG5361 266264016881 Protein of unknown function (DUF1254); Region: DUF1254; pfam06863 266264016882 Protein of unknown function (DUF1214); Region: DUF1214; cl08447 266264016883 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 266264016884 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 266264016885 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 266264016886 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 266264016887 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 266264016888 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 266264016889 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 266264016890 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 266264016891 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 266264016892 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 266264016893 catalytic residue [active] 266264016894 Putative phosphatase (DUF442); Region: DUF442; cl17385 266264016895 Predicted transcriptional regulators [Transcription]; Region: COG1510 266264016896 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 266264016897 dimerization interface [polypeptide binding]; other site 266264016898 putative DNA binding site [nucleotide binding]; other site 266264016899 putative Zn2+ binding site [ion binding]; other site 266264016900 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 266264016901 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 266264016902 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 266264016903 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 266264016904 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472 266264016905 Tetratricopeptide repeat; Region: TPR_16; pfam13432 266264016906 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 266264016907 TPR motif; other site 266264016908 binding surface 266264016909 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 266264016910 binding surface 266264016911 TPR motif; other site 266264016912 Tetratricopeptide repeat; Region: TPR_16; pfam13432 266264016913 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 266264016914 TPR motif; other site 266264016915 binding surface 266264016916 TPR repeat; Region: TPR_11; pfam13414 266264016917 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 266264016918 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 266264016919 inhibitor-cofactor binding pocket; inhibition site 266264016920 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266264016921 catalytic residue [active] 266264016922 WbqC-like protein family; Region: WbqC; pfam08889 266264016923 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 266264016924 Methyltransferase domain; Region: Methyltransf_23; pfam13489 266264016925 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 266264016926 S-adenosylmethionine binding site [chemical binding]; other site 266264016927 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 266264016928 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 266264016929 Methyltransferase domain; Region: Methyltransf_23; pfam13489 266264016930 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 266264016931 S-adenosylmethionine binding site [chemical binding]; other site 266264016932 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 266264016933 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266264016934 putative substrate translocation pore; other site 266264016935 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266264016936 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266264016937 The C-terminal substrate binding domain of LysR-type transcriptional regulator ToxR regulates the expression of the toxoflavin biosynthesis genes; contains the type 2 periplasmic bindinig fold; Region: PBP2_ToxR; cd08465 266264016938 putative substrate binding pocket [chemical binding]; other site 266264016939 putative dimerization interface [polypeptide binding]; other site 266264016940 Protein of unknown function, DUF606; Region: DUF606; pfam04657 266264016941 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266264016942 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266264016943 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 266264016944 dimerization interface [polypeptide binding]; other site 266264016945 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 266264016946 putative CoA-transferase; Provisional; Region: PRK11430 266264016947 CoA-transferase family III; Region: CoA_transf_3; pfam02515 266264016948 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 266264016949 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 266264016950 dimerization interface [polypeptide binding]; other site 266264016951 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 266264016952 dimer interface [polypeptide binding]; other site 266264016953 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 266264016954 putative CheW interface [polypeptide binding]; other site 266264016955 bacterial Hfq-like; Region: Hfq; cd01716 266264016956 hexamer interface [polypeptide binding]; other site 266264016957 Sm1 motif; other site 266264016958 RNA binding site [nucleotide binding]; other site 266264016959 Sm2 motif; other site 266264016960 flagellin; Validated; Region: PRK06819 266264016961 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 266264016962 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 266264016963 FlaG protein; Region: FlaG; pfam03646 266264016964 flagellar capping protein; Reviewed; Region: fliD; PRK08032 266264016965 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 266264016966 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 266264016967 flagellar protein FliS; Validated; Region: fliS; PRK05685 266264016968 Flagellar protein FliT; Region: FliT; cl05125 266264016969 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 266264016970 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 266264016971 flagellar hook-basal body protein FliE; Reviewed; Region: fliE; PRK00253 266264016972 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 266264016973 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; pfam01514 266264016974 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 266264016975 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 266264016976 FliG C-terminal domain; Region: FliG_C; pfam01706 266264016977 flagellar assembly protein H; Validated; Region: fliH; PRK05687 266264016978 Flagellar assembly protein FliH; Region: FliH; pfam02108 266264016979 flagellar protein export ATPase FliI; Region: FliI_clade1; TIGR03496 266264016980 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 266264016981 Walker A motif/ATP binding site; other site 266264016982 Walker B motif; other site 266264016983 flagellar biosynthesis chaperone; Validated; Region: fliJ; PRK05689 266264016984 Flagellar FliJ protein; Region: FliJ; pfam02050 266264016985 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 266264016986 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 266264016987 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 266264016988 alpha-ketoglutarate-dependent dioxygenase AlkB; Provisional; Region: PRK15401 266264016989 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 266264016990 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 266264016991 transmembrane helices; other site 266264016992 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 266264016993 non-specific DNA binding site [nucleotide binding]; other site 266264016994 salt bridge; other site 266264016995 sequence-specific DNA binding site [nucleotide binding]; other site 266264016996 dihydroxy-acid dehydratase; Provisional; Region: PRK13016 266264016997 hypothetical protein; Validated; Region: PRK08245 266264016998 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 266264016999 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 266264017000 Hydroxy(phenyl)pyruvate Reductase, D-isomer-specific 2-hydroxyacid-related dehydrogenase; Region: HPPR; cd12156 266264017001 putative ligand binding site [chemical binding]; other site 266264017002 NAD binding site [chemical binding]; other site 266264017003 catalytic site [active] 266264017004 Intradiol dioxygenase supgroup. Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. They break the catechol C1-C2 bond and utilize Fe3+, as opposed to the...; Region: intradiol_dioxygenase_like; cd03457 266264017005 putative active site [active] 266264017006 Predicted signal transduction protein containing sensor and EAL domains [Signal transduction mechanisms]; Region: COG4943 266264017007 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 266264017008 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 266264017009 LysE type translocator; Region: LysE; cl00565 266264017010 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 266264017011 nitrogen assimilation transcriptional regulator; Provisional; Region: PRK11233 266264017012 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266264017013 The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433 266264017014 putative dimerization interface [polypeptide binding]; other site 266264017015 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 266264017016 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 266264017017 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 266264017018 Beta-lactamase; Region: Beta-lactamase; pfam00144 266264017019 ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776 266264017020 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 266264017021 ATP binding site [chemical binding]; other site 266264017022 Mg++ binding site [ion binding]; other site 266264017023 motif III; other site 266264017024 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 266264017025 nucleotide binding region [chemical binding]; other site 266264017026 ATP-binding site [chemical binding]; other site 266264017027 RNA recognition motif in Escherichia coli RNA helicase dbpA and similar proteins; Region: RRM_EcDbpA_like; cd12501 266264017028 putative RNA binding site [nucleotide binding]; other site 266264017029 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 266264017030 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 266264017031 NADP binding site [chemical binding]; other site 266264017032 dimer interface [polypeptide binding]; other site 266264017033 Prokaryotic protein of unknown function (DUF849); Region: DUF849; pfam05853 266264017034 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 266264017035 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 266264017036 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 266264017037 eyelet of channel; other site 266264017038 trimer interface [polypeptide binding]; other site 266264017039 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK12825 266264017040 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266264017041 NAD(P) binding site [chemical binding]; other site 266264017042 active site 266264017043 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 266264017044 classical (c) SDRs; Region: SDR_c; cd05233 266264017045 NAD(P) binding site [chemical binding]; other site 266264017046 active site 266264017047 potential protein location (hypothetical protein) that overlaps protein (3-oxoacyl-ACP reductase (3-ketoacyl- acyl carrier protein reductase)) 266264017048 Prokaryotic protein of unknown function (DUF849); Region: DUF849; pfam05853 266264017049 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 266264017050 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 266264017051 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 266264017052 Serine hydrolase; Region: Ser_hydrolase; pfam06821 266264017053 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 266264017054 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 266264017055 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 266264017056 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 266264017057 bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238 266264017058 Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576 266264017059 substrate binding site [chemical binding]; other site 266264017060 Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581 266264017061 substrate binding site [chemical binding]; other site 266264017062 ligand binding site [chemical binding]; other site 266264017063 flagellar basal body-associated protein FliL; Reviewed; Region: fliL; PRK07021 266264017064 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 266264017065 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 266264017066 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 266264017067 Flagellar biogenesis protein [Cell motility and secretion]; Region: FliO; COG3190 266264017068 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 266264017069 flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700 266264017070 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 266264017071 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 266264017072 Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858 266264017073 methyl-accepting chemotaxis protein II; Provisional; Region: PRK15048 266264017074 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 266264017075 dimerization interface [polypeptide binding]; other site 266264017076 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 266264017077 dimer interface [polypeptide binding]; other site 266264017078 putative CheW interface [polypeptide binding]; other site 266264017079 NnrS protein; Region: NnrS; pfam05940 266264017080 Transcription factor zinc-finger; Region: zf-TFIIB; cl01565 266264017081 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 266264017082 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 266264017083 substrate binding site [chemical binding]; other site 266264017084 activation loop (A-loop); other site 266264017085 AAA ATPase domain; Region: AAA_16; pfam13191 266264017086 Predicted ATPase [General function prediction only]; Region: COG3899 266264017087 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 266264017088 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266264017089 ATP binding site [chemical binding]; other site 266264017090 Mg2+ binding site [ion binding]; other site 266264017091 G-X-G motif; other site 266264017092 Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566 266264017093 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266264017094 active site 266264017095 phosphorylation site [posttranslational modification] 266264017096 intermolecular recognition site; other site 266264017097 dimerization interface [polypeptide binding]; other site 266264017098 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 266264017099 DNA binding residues [nucleotide binding] 266264017100 dimerization interface [polypeptide binding]; other site 266264017101 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 266264017102 Isochorismatase family; Region: Isochorismatase; pfam00857 266264017103 catalytic triad [active] 266264017104 dimer interface [polypeptide binding]; other site 266264017105 conserved cis-peptide bond; other site 266264017106 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 266264017107 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 266264017108 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 266264017109 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 266264017110 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 266264017111 active site 266264017112 Predicted membrane protein [Function unknown]; Region: COG2259 266264017113 Transmembrane secretion effector; Region: MFS_3; pfam05977 266264017114 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266264017115 Protein of unknown function (DUF1427); Region: DUF1427; pfam07235 266264017116 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266264017117 Response regulator receiver domain; Region: Response_reg; pfam00072 266264017118 active site 266264017119 phosphorylation site [posttranslational modification] 266264017120 intermolecular recognition site; other site 266264017121 dimerization interface [polypeptide binding]; other site 266264017122 Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566 266264017123 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266264017124 active site 266264017125 phosphorylation site [posttranslational modification] 266264017126 intermolecular recognition site; other site 266264017127 dimerization interface [polypeptide binding]; other site 266264017128 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 266264017129 DNA binding residues [nucleotide binding] 266264017130 dimerization interface [polypeptide binding]; other site 266264017131 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 266264017132 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 266264017133 HlyD family secretion protein; Region: HlyD_3; pfam13437 266264017134 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 266264017135 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 266264017136 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 266264017137 HAMP domain; Region: HAMP; pfam00672 266264017138 dimerization interface [polypeptide binding]; other site 266264017139 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 266264017140 dimer interface [polypeptide binding]; other site 266264017141 phosphorylation site [posttranslational modification] 266264017142 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266264017143 ATP binding site [chemical binding]; other site 266264017144 Mg2+ binding site [ion binding]; other site 266264017145 G-X-G motif; other site 266264017146 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 266264017147 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266264017148 active site 266264017149 phosphorylation site [posttranslational modification] 266264017150 intermolecular recognition site; other site 266264017151 dimerization interface [polypeptide binding]; other site 266264017152 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 266264017153 DNA binding residues [nucleotide binding] 266264017154 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 266264017155 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 266264017156 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 266264017157 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 266264017158 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266264017159 active site 266264017160 phosphorylation site [posttranslational modification] 266264017161 intermolecular recognition site; other site 266264017162 dimerization interface [polypeptide binding]; other site 266264017163 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 266264017164 DNA binding site [nucleotide binding] 266264017165 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 266264017166 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 266264017167 dimer interface [polypeptide binding]; other site 266264017168 phosphorylation site [posttranslational modification] 266264017169 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266264017170 ATP binding site [chemical binding]; other site 266264017171 Mg2+ binding site [ion binding]; other site 266264017172 G-X-G motif; other site 266264017173 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 266264017174 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 266264017175 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 266264017176 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 266264017177 HlyD family secretion protein; Region: HlyD_3; pfam13437 266264017178 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 266264017179 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266264017180 active site 266264017181 phosphorylation site [posttranslational modification] 266264017182 intermolecular recognition site; other site 266264017183 dimerization interface [polypeptide binding]; other site 266264017184 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 266264017185 DNA binding site [nucleotide binding] 266264017186 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 266264017187 dimerization interface [polypeptide binding]; other site 266264017188 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 266264017189 dimer interface [polypeptide binding]; other site 266264017190 phosphorylation site [posttranslational modification] 266264017191 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266264017192 ATP binding site [chemical binding]; other site 266264017193 Mg2+ binding site [ion binding]; other site 266264017194 G-X-G motif; other site 266264017195 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 266264017196 MgtC family; Region: MgtC; pfam02308 266264017197 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 266264017198 Adenosine specific kinase; Region: Adenosine_kin; pfam04008 266264017199 Putative bacterial lipoprotein (DUF799); Region: DUF799; cl01813 266264017200 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4259 266264017201 Uncharacterized protein involved in formation of curli polymers [Cell envelope biogenesis, outer membrane]; Region: CsgG; COG1462 266264017202 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 266264017203 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 266264017204 Haemolysin secretion/activation protein ShlB/FhaC/HecB; Region: ShlB; pfam03865 266264017205 haemagglutination activity domain; Region: Haemagg_act; pfam05860 266264017206 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 266264017207 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 266264017208 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 266264017209 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 266264017210 Bestrophin, RFP-TM, chloride channel; Region: Bestrophin; pfam01062 266264017211 Cytochrome c [Energy production and conversion]; Region: COG3258 266264017212 Cytochrome c; Region: Cytochrom_C; pfam00034 266264017213 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 266264017214 PAS fold; Region: PAS_4; pfam08448 266264017215 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 266264017216 putative active site [active] 266264017217 heme pocket [chemical binding]; other site 266264017218 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 266264017219 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 266264017220 Walker A motif; other site 266264017221 ATP binding site [chemical binding]; other site 266264017222 Walker B motif; other site 266264017223 arginine finger; other site 266264017224 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 266264017225 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 266264017226 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266264017227 Major Facilitator Superfamily; Region: MFS_1; pfam07690 266264017228 putative substrate translocation pore; other site 266264017229 Pyridoxamine 5'-phosphate oxidase; Region: Pyrid_oxidase_2; pfam13883 266264017230 conserved hypothetical protein 266264017231 Protein of unknown function (DUF3300); Region: DUF3300; pfam11737 266264017232 Protein of unknown function (DUF2950); Region: DUF2950; pfam11453 266264017233 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 266264017234 membrane-bound complex binding site; other site 266264017235 hypothetical protein; Provisional; Region: PRK10593 266264017236 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 266264017237 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 266264017238 active site 266264017239 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 266264017240 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 266264017241 ABC-type phosphate/phosphonate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PhnD; COG3221 266264017242 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 266264017243 membrane-bound complex binding site; other site 266264017244 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266264017245 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266264017246 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 266264017247 substrate binding pocket [chemical binding]; other site 266264017248 dimerization interface [polypeptide binding]; other site 266264017249 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 266264017250 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 266264017251 substrate binding site [chemical binding]; other site 266264017252 oxyanion hole (OAH) forming residues; other site 266264017253 trimer interface [polypeptide binding]; other site 266264017254 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 266264017255 CoA-transferase family III; Region: CoA_transf_3; pfam02515 266264017256 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 266264017257 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 266264017258 FMN binding site [chemical binding]; other site 266264017259 active site 266264017260 substrate binding site [chemical binding]; other site 266264017261 catalytic residue [active] 266264017262 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 266264017263 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 266264017264 active site 266264017265 catalytic tetrad [active] 266264017266 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266264017267 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266264017268 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA; cd08478 266264017269 putative effector binding pocket; other site 266264017270 dimerization interface [polypeptide binding]; other site 266264017271 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 266264017272 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 266264017273 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266264017274 putative substrate translocation pore; other site 266264017275 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 266264017276 CoA binding domain; Region: CoA_binding_2; pfam13380 266264017277 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 266264017278 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 266264017279 Uncharacterized protein involved in propionate catabolism [General function prediction only]; Region: PrpD; COG2079 266264017280 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266264017281 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266264017282 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_1; cd08421 266264017283 putative dimerization interface [polypeptide binding]; other site 266264017284 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 266264017285 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 266264017286 N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649 266264017287 dimer interface [polypeptide binding]; other site 266264017288 active site 266264017289 heme binding site [chemical binding]; other site 266264017290 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 266264017291 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cd04332 266264017292 putative deacylase active site [active] 266264017293 Outer membrane receptor for ferrienterochelin and colicins [Inorganic ion transport and metabolism]; Region: FepA; COG4771 266264017294 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 266264017295 N-terminal plug; other site 266264017296 ligand-binding site [chemical binding]; other site 266264017297 Bacterial proteins similar to Porphyromonas gingivalis HmuY; Region: HmuY; cd12105 266264017298 Putative heme degradation protein [Inorganic ion transport and metabolism]; Region: HemS; COG3720 266264017299 Haemin-degrading HemS.ChuX domain; Region: HemS; pfam05171 266264017300 Haemin-degrading HemS.ChuX domain; Region: HemS; pfam05171 266264017301 Hemin binding protein HutB. These proteins have been shown to function as initial receptors in ABC transport of hemin and hemoproteins in many eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a...; Region: HutB; cd01149 266264017302 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 266264017303 putative hemin binding site; other site 266264017304 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 266264017305 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 266264017306 ABC-ATPase subunit interface; other site 266264017307 dimer interface [polypeptide binding]; other site 266264017308 putative PBP binding regions; other site 266264017309 hemin importer ATP-binding subunit; Provisional; Region: hmuV; PRK13548 266264017310 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 266264017311 Walker A/P-loop; other site 266264017312 ATP binding site [chemical binding]; other site 266264017313 Q-loop/lid; other site 266264017314 ABC transporter signature motif; other site 266264017315 Walker B; other site 266264017316 D-loop; other site 266264017317 H-loop/switch region; other site 266264017318 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 266264017319 classical (c) SDRs; Region: SDR_c; cd05233 266264017320 NAD(P) binding site [chemical binding]; other site 266264017321 active site 266264017322 Citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CCL cleaves citryl-CoA (CiCoA) to acetyl-CoA (AcCoA) and oxaloacetate (OAA); Region: CCL_ACL-C; cd06100 266264017323 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 266264017324 active site 266264017325 oxalacetate binding site [chemical binding]; other site 266264017326 citrylCoA binding site [chemical binding]; other site 266264017327 coenzyme A binding site [chemical binding]; other site 266264017328 catalytic triad [active] 266264017329 acyl-CoA synthetase; Validated; Region: PRK06188 266264017330 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 266264017331 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 266264017332 acyl-activating enzyme (AAE) consensus motif; other site 266264017333 acyl-activating enzyme (AAE) consensus motif; other site 266264017334 putative AMP binding site [chemical binding]; other site 266264017335 putative active site [active] 266264017336 putative CoA binding site [chemical binding]; other site 266264017337 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 266264017338 Transcriptional regulator [Transcription]; Region: IclR; COG1414 266264017339 IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339 266264017340 Bacterial transcriptional regulator; Region: IclR; pfam01614 266264017341 Protein of unknown function (DUF2905); Region: DUF2905; pfam11146 266264017342 AAA domain; Region: AAA_28; pfam13521 266264017343 Predicted ATPase [General function prediction only]; Region: COG3911 266264017344 Short repeat of unknown function (DUF308); Region: DUF308; pfam03729 266264017345 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 266264017346 ApbE family; Region: ApbE; pfam02424 266264017347 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 266264017348 Flavodoxin; Region: Flavodoxin_1; pfam00258 266264017349 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR_like2; cd06201 266264017350 FAD binding pocket [chemical binding]; other site 266264017351 FAD binding motif [chemical binding]; other site 266264017352 catalytic residues [active] 266264017353 NAD binding pocket [chemical binding]; other site 266264017354 phosphate binding motif [ion binding]; other site 266264017355 beta-alpha-beta structure motif; other site 266264017356 Predicted periplasmic protein (DUF2271); Region: DUF2271; pfam10029 266264017357 Peptidase propeptide and YPEB domain; Region: PepSY_2; pfam13670 266264017358 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 266264017359 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266264017360 active site 266264017361 phosphorylation site [posttranslational modification] 266264017362 intermolecular recognition site; other site 266264017363 dimerization interface [polypeptide binding]; other site 266264017364 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 266264017365 DNA binding site [nucleotide binding] 266264017366 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 266264017367 HAMP domain; Region: HAMP; pfam00672 266264017368 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 266264017369 dimer interface [polypeptide binding]; other site 266264017370 phosphorylation site [posttranslational modification] 266264017371 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266264017372 ATP binding site [chemical binding]; other site 266264017373 Mg2+ binding site [ion binding]; other site 266264017374 G-X-G motif; other site 266264017375 Protein of unknown function (DUF2478); Region: DUF2478; pfam10649 266264017376 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 266264017377 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 266264017378 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 266264017379 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 266264017380 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 266264017381 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 266264017382 motif II; other site 266264017383 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 266264017384 polyphosphate:nucleotide phosphotransferase, PPK2 family; Region: PPK2_rel_1; TIGR03709 266264017385 BON domain; Region: BON; cl02771 266264017386 Domain of unknown function (DUF305); Region: DUF305; cl17794 266264017387 Uncharacterized conserved protein [Function unknown]; Region: COG3391 266264017388 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 266264017389 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 266264017390 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 266264017391 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 266264017392 DNA binding residues [nucleotide binding] 266264017393 Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662 266264017394 Alkyl sulfatase and related hydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2015 266264017395 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 266264017396 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4320 266264017397 Uncharacterized protein conserved in bacteria (DUF2252); Region: DUF2252; pfam10009 266264017398 Predicted periplasmic protein (DUF2092); Region: DUF2092; pfam09865 266264017399 Domain of unknown function (DUF4347); Region: DUF4347; pfam14252 266264017400 VCBS repeat; Region: VCBS_repeat; TIGR01965 266264017401 VCBS repeat; Region: VCBS_repeat; TIGR01965 266264017402 VCBS repeat; Region: VCBS_repeat; TIGR01965 266264017403 VCBS repeat; Region: VCBS_repeat; TIGR01965 266264017404 VCBS repeat; Region: VCBS_repeat; TIGR01965 266264017405 VCBS repeat; Region: VCBS_repeat; TIGR01965 266264017406 VCBS repeat; Region: VCBS_repeat; TIGR01965 266264017407 VCBS repeat; Region: VCBS_repeat; TIGR01965 266264017408 VCBS repeat; Region: VCBS_repeat; TIGR01965 266264017409 VCBS repeat; Region: VCBS_repeat; TIGR01965 266264017410 VCBS repeat; Region: VCBS_repeat; TIGR01965 266264017411 Outer membrane efflux protein; Region: OEP; pfam02321 266264017412 Outer membrane efflux protein; Region: OEP; pfam02321 266264017413 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 266264017414 HlyD family secretion protein; Region: HlyD_3; pfam13437 266264017415 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 266264017416 HlyD family secretion protein; Region: HlyD_3; pfam13437 266264017417 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 266264017418 active site 266264017419 putative substrate binding region [chemical binding]; other site 266264017420 HlyD family secretion protein; Region: HlyD_3; pfam13437 266264017421 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 266264017422 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 266264017423 Coniferyl aldehyde dehydrogenase-like; Region: ALDH_CALDH_CalB; cd07133 266264017424 NAD(P) binding site [chemical binding]; other site 266264017425 catalytic residues [active] 266264017426 choline dehydrogenase; Validated; Region: PRK02106 266264017427 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 266264017428 Alkyl sulfatase and related hydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2015 266264017429 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 266264017430 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 266264017431 Sulfatase; Region: Sulfatase; pfam00884 266264017432 putative DNA-binding transcriptional regulator; Provisional; Region: PRK09791 266264017433 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266264017434 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 266264017435 dimerization interface [polypeptide binding]; other site 266264017436 citrate-proton symporter; Provisional; Region: PRK15075 266264017437 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266264017438 putative substrate translocation pore; other site 266264017439 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 266264017440 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 266264017441 metal binding site [ion binding]; metal-binding site 266264017442 putative dimer interface [polypeptide binding]; other site 266264017443 NLPA lipoprotein; Region: Lipoprotein_9; cl17547 266264017444 Uncharacterized conserved protein [Function unknown]; Region: COG1262 266264017445 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 266264017446 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 266264017447 Sulfatase; Region: Sulfatase; cl17466 266264017448 Sulfatase; Region: Sulfatase; cl17466 266264017449 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 266264017450 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266264017451 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 266264017452 dimerization interface [polypeptide binding]; other site 266264017453 substrate binding pocket [chemical binding]; other site 266264017454 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 266264017455 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 266264017456 active site 266264017457 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 266264017458 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 266264017459 putative acyl-acceptor binding pocket; other site 266264017460 enoyl-CoA hydratase; Provisional; Region: PRK07509 266264017461 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 266264017462 substrate binding site [chemical binding]; other site 266264017463 oxyanion hole (OAH) forming residues; other site 266264017464 trimer interface [polypeptide binding]; other site 266264017465 acetyl-CoA acetyltransferase; Provisional; Region: PRK06504 266264017466 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 266264017467 dimer interface [polypeptide binding]; other site 266264017468 active site 266264017469 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266264017470 NAD(P) binding site [chemical binding]; other site 266264017471 active site 266264017472 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 266264017473 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 266264017474 FMN binding site [chemical binding]; other site 266264017475 substrate binding site [chemical binding]; other site 266264017476 putative catalytic residue [active] 266264017477 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 266264017478 CoA-transferase family III; Region: CoA_transf_3; pfam02515 266264017479 ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909 266264017480 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 266264017481 DNA binding residues [nucleotide binding] 266264017482 dimerization interface [polypeptide binding]; other site 266264017483 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 266264017484 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 266264017485 active site 266264017486 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 266264017487 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 266264017488 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 266264017489 acyl-activating enzyme (AAE) consensus motif; other site 266264017490 acyl-activating enzyme (AAE) consensus motif; other site 266264017491 putative AMP binding site [chemical binding]; other site 266264017492 putative active site [active] 266264017493 putative CoA binding site [chemical binding]; other site 266264017494 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07008 266264017495 Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; Region: ttLC_FACS_AlkK_like; cd12119 266264017496 dimer interface [polypeptide binding]; other site 266264017497 acyl-activating enzyme (AAE) consensus motif; other site 266264017498 putative active site [active] 266264017499 AMP binding site [chemical binding]; other site 266264017500 putative CoA binding site [chemical binding]; other site 266264017501 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 266264017502 active site 266264017503 Uncharacterized conserved protein [Function unknown]; Region: COG1359 266264017504 Glycerol-3-phosphate responsive antiterminator; Region: G3P_antiterm; cl00852 266264017505 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 266264017506 FAD binding domain; Region: FAD_binding_4; pfam01565 266264017507 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 266264017508 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 266264017509 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 266264017510 Glycerol kinase [Energy production and conversion]; Region: GlpK; COG0554 266264017511 nucleotide binding site [chemical binding]; other site 266264017512 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266264017513 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 266264017514 putative substrate translocation pore; other site 266264017515 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 266264017516 SnoaL-like polyketide cyclase; Region: SnoaL; pfam07366 266264017517 Uncharacterized protein conserved in bacteria (DUF2086); Region: DUF2086; cl17606 266264017518 putative transposase OrfB; Reviewed; Region: PHA02517 266264017519 HTH-like domain; Region: HTH_21; pfam13276 266264017520 Integrase core domain; Region: rve; pfam00665 266264017521 Integrase core domain; Region: rve_3; pfam13683 266264017522 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 266264017523 Transposase; Region: HTH_Tnp_1; cl17663 266264017524 transposon Tn7 transposition protein TnsC (fragment) 266264017525 putative transposase OrfB; Reviewed; Region: PHA02517 266264017526 HTH-like domain; Region: HTH_21; pfam13276 266264017527 Integrase core domain; Region: rve; pfam00665 266264017528 Integrase core domain; Region: rve_2; pfam13333 266264017529 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 266264017530 Transposase; Region: HTH_Tnp_1; pfam01527 266264017531 Tn7-like transposition protein C 266264017532 TnsA endonuclease N terminal; Region: Tn7_Tnp_TnsA_N; pfam08722 266264017533 potential protein location (hypothetical protein) that overlaps protein (conserved hypothetical protein) 266264017534 Uncharacterized conserved protein [Function unknown]; Region: COG4127 266264017535 Predicted type IV restriction endonuclease [Defense mechanisms]; Region: COG2810 266264017536 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 266264017537 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266264017538 DNA-binding site [nucleotide binding]; DNA binding site 266264017539 UTRA domain; Region: UTRA; pfam07702 266264017540 Fumarase C-terminus; Region: Fumerase_C; cl00795 266264017541 fumarate hydratase; Provisional; Region: PRK06246 266264017542 Mandelate racemase (MR)-like subfamily of the enolase superfamily, subgroup 1. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic...; Region: MR_like_1; cd03326 266264017543 putative active site pocket [active] 266264017544 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 266264017545 metal binding site [ion binding]; metal-binding site 266264017546 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 266264017547 conserved hypothetical protein (fragment) 266264017548 AAA domain; Region: AAA_22; pfam13401 266264017549 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 266264017550 Walker A motif; other site 266264017551 ATP binding site [chemical binding]; other site 266264017552 Walker B motif; other site 266264017553 arginine finger; other site 266264017554 Integrase core domain; Region: rve; pfam00665 266264017555 conserved hypothetical protein (fragment) 266264017556 D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl17344 266264017557 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 266264017558 Part of AAA domain; Region: AAA_19; pfam13245 266264017559 Family description; Region: UvrD_C_2; pfam13538 266264017560 potential protein location (hypothetical protein) that overlaps protein ( ATP-dependent DNA helicase Rep) 266264017561 Protein of unknown function (DUF2813); Region: DUF2813; pfam11398 266264017562 AAA domain; Region: AAA_21; pfam13304 266264017563 TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family. The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026 266264017564 putative active site [active] 266264017565 putative metal-binding site [ion binding]; other site 266264017566 Fusaric acid resistance protein family; Region: FUSC; pfam04632 266264017567 4-hydroxybenzoate 3-monooxygenase; Validated; Region: PRK08243 266264017568 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 266264017569 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 266264017570 putative succinate dehydrogenase; Reviewed; Region: PRK12842 266264017571 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 266264017572 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 266264017573 NIPSNAP; Region: NIPSNAP; pfam07978 266264017574 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 266264017575 NADPH:quinone reductase, Zn-dependent (fragment) 266264017576 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 266264017577 Transposase; Region: HTH_Tnp_1; pfam01527 266264017578 putative transposase OrfB; Reviewed; Region: PHA02517 266264017579 HTH-like domain; Region: HTH_21; pfam13276 266264017580 Integrase core domain; Region: rve; pfam00665 266264017581 Integrase core domain; Region: rve_2; pfam13333 266264017582 NADPH:quinone reductase, Zn-dependent (fragment) 266264017583 acetyl-CoA acetyltransferase; Provisional; Region: PRK08142 266264017584 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 266264017585 active site 266264017586 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 266264017587 DUF35 OB-fold domain; Region: DUF35; pfam01796 266264017588 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 266264017589 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 266264017590 substrate binding site [chemical binding]; other site 266264017591 oxyanion hole (OAH) forming residues; other site 266264017592 trimer interface [polypeptide binding]; other site 266264017593 short chain dehydrogenase; Provisional; Region: PRK08278 266264017594 human hydroxysteroid dehydrogenase-like protein 2 (HSDL2), classical (c) SDRs; Region: HSDL2_SDR_c; cd09762 266264017595 NAD(P) binding site [chemical binding]; other site 266264017596 homodimer interface [polypeptide binding]; other site 266264017597 active site 266264017598 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 266264017599 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 266264017600 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 266264017601 trimer interface [polypeptide binding]; other site 266264017602 eyelet of channel; other site 266264017603 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 266264017604 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 266264017605 substrate binding site [chemical binding]; other site 266264017606 oxyanion hole (OAH) forming residues; other site 266264017607 trimer interface [polypeptide binding]; other site 266264017608 Cupin domain; Region: Cupin_2; cl17218 266264017609 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 266264017610 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 266264017611 active site 266264017612 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08314 266264017613 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 266264017614 acyl-activating enzyme (AAE) consensus motif; other site 266264017615 AMP binding site [chemical binding]; other site 266264017616 active site 266264017617 CoA binding site [chemical binding]; other site 266264017618 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266264017619 NAD(P) binding site [chemical binding]; other site 266264017620 active site 266264017621 acetyl-CoA acetyltransferase; Validated; Region: PRK08242 266264017622 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 266264017623 dimer interface [polypeptide binding]; other site 266264017624 active site 266264017625 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 266264017626 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 266264017627 substrate binding site [chemical binding]; other site 266264017628 oxyanion hole (OAH) forming residues; other site 266264017629 trimer interface [polypeptide binding]; other site 266264017630 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 266264017631 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 266264017632 enoyl-CoA hydratase; Provisional; Region: PRK06142 266264017633 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 266264017634 substrate binding site [chemical binding]; other site 266264017635 oxyanion hole (OAH) forming residues; other site 266264017636 trimer interface [polypeptide binding]; other site 266264017637 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 266264017638 Helix-turn-helix domain; Region: HTH_18; pfam12833 266264017639 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 266264017640 potential protein location (hypothetical protein) that overlaps protein ( transcriptional regulator, AraC family) 266264017641 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 266264017642 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266264017643 NAD(P) binding site [chemical binding]; other site 266264017644 active site 266264017645 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 266264017646 Streptomyces aureofaciens putative aldehyde dehydrogenase AldA (AAD23400)-like; Region: ALDH_AldA-AAD23400; cd07106 266264017647 NAD(P) binding site [chemical binding]; other site 266264017648 catalytic residues [active] 266264017649 Cytochrome P450; Region: p450; cl12078 266264017650 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 266264017651 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 266264017652 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 266264017653 FMN-binding pocket [chemical binding]; other site 266264017654 flavin binding motif; other site 266264017655 phosphate binding motif [ion binding]; other site 266264017656 beta-alpha-beta structure motif; other site 266264017657 NAD binding pocket [chemical binding]; other site 266264017658 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 266264017659 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 266264017660 catalytic loop [active] 266264017661 iron binding site [ion binding]; other site 266264017662 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 266264017663 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 266264017664 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 266264017665 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 266264017666 Ligand binding site [chemical binding]; other site 266264017667 Electron transfer flavoprotein domain; Region: ETF; pfam01012 266264017668 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 266264017669 HDE_HSD The R-hydratase-like hot dog fold of the 17-beta-hydroxysteriod dehydrogenase (HSD), and Hydratase-Dehydrogenase-Epimerase (HDE) proteins. Other enzymes with this fold include MaoC dehydratase, and the fatty acid synthase beta subunit; Region: HDE_HSD; cd03448 266264017670 dimer interaction site [polypeptide binding]; other site 266264017671 substrate-binding tunnel; other site 266264017672 active site 266264017673 catalytic site [active] 266264017674 substrate binding site [chemical binding]; other site 266264017675 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 266264017676 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 266264017677 substrate binding site [chemical binding]; other site 266264017678 oxyanion hole (OAH) forming residues; other site 266264017679 trimer interface [polypeptide binding]; other site 266264017680 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 266264017681 putative active site [active] 266264017682 putative substrate binding site [chemical binding]; other site 266264017683 ATP binding site [chemical binding]; other site 266264017684 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 266264017685 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266264017686 NAD(P) binding site [chemical binding]; other site 266264017687 active site 266264017688 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 266264017689 CoA-transferase family III; Region: CoA_transf_3; pfam02515 266264017690 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 266264017691 Phosphotransferase enzyme family; Region: APH; pfam01636 266264017692 putative active site [active] 266264017693 putative substrate binding site [chemical binding]; other site 266264017694 ATP binding site [chemical binding]; other site 266264017695 long-chain-fatty-acid--CoA ligase; Provisional; Region: PRK12406 266264017696 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 266264017697 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 266264017698 acyl-activating enzyme (AAE) consensus motif; other site 266264017699 putative AMP binding site [chemical binding]; other site 266264017700 putative active site [active] 266264017701 putative CoA binding site [chemical binding]; other site 266264017702 pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203 266264017703 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 266264017704 active site 266264017705 pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204 266264017706 Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26; Region: ACAD_fadE6_17_26; cd01152 266264017707 FAD binding site [chemical binding]; other site 266264017708 substrate binding site [chemical binding]; other site 266264017709 catalytic base [active] 266264017710 Transcriptional regulators [Transcription]; Region: FadR; COG2186 266264017711 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266264017712 DNA-binding site [nucleotide binding]; DNA binding site 266264017713 FCD domain; Region: FCD; pfam07729 266264017714 Transcriptional regulators [Transcription]; Region: FadR; COG2186 266264017715 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266264017716 DNA-binding site [nucleotide binding]; DNA binding site 266264017717 FCD domain; Region: FCD; pfam07729 266264017718 Nitroreductase family. Members of this family utilize FMN as a cofactor and catalyze reduction of a variety of nitroaromatic compounds, including nitrofurans, nitrobenzens, nitrophenol, nitrobenzoate and quinones by using either NADH or NADPH as a source...; Region: Nitroreductase; cd02136 266264017719 putative FMN binding site [chemical binding]; other site 266264017720 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 266264017721 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 266264017722 FMN binding site [chemical binding]; other site 266264017723 substrate binding site [chemical binding]; other site 266264017724 putative catalytic residue [active] 266264017725 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 266264017726 CoA-transferase family III; Region: CoA_transf_3; pfam02515 266264017727 Protein of unknown function (DUF2889); Region: DUF2889; pfam11136 266264017728 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 266264017729 active site 2 [active] 266264017730 active site 1 [active] 266264017731 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 266264017732 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 266264017733 active site 266264017734 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 266264017735 DUF35 OB-fold domain; Region: DUF35; pfam01796 266264017736 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 266264017737 active site 266264017738 putative transposase OrfB; Reviewed; Region: PHA02517 266264017739 HTH-like domain; Region: HTH_21; pfam13276 266264017740 Integrase core domain; Region: rve; pfam00665 266264017741 Integrase core domain; Region: rve_3; pfam13683 266264017742 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 266264017743 CoA-transferase family III; Region: CoA_transf_3; pfam02515 266264017744 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 266264017745 Streptomyces aureofaciens putative aldehyde dehydrogenase AldA (AAD23400)-like; Region: ALDH_AldA-AAD23400; cd07106 266264017746 NAD(P) binding site [chemical binding]; other site 266264017747 catalytic residues [active] 266264017748 6-hydroxyhexanoate dehydrogenase; Region: 6_hydroxyhexanoate_dh_like; cd08240 266264017749 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 266264017750 putative NAD(P) binding site [chemical binding]; other site 266264017751 catalytic Zn binding site [ion binding]; other site 266264017752 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 266264017753 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 266264017754 iron-sulfur cluster [ion binding]; other site 266264017755 [2Fe-2S] cluster binding site [ion binding]; other site 266264017756 C-terminal catalytic domain of the oxygenase alpha subunit of dicamba O-demethylase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_DMO-like; cd08878 266264017757 alpha subunit interface [polypeptide binding]; other site 266264017758 active site 266264017759 substrate binding site [chemical binding]; other site 266264017760 Fe binding site [ion binding]; other site 266264017761 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 266264017762 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 266264017763 DNA binding residues [nucleotide binding] 266264017764 dimerization interface [polypeptide binding]; other site 266264017765 Rieske non-heme iron oxygenase (RO) family, Phthalate 4,5-dioxygenase (PhDO)-like subfamily, N-terminal Rieske domain of the oxygenase alpha subunit; composed of the oxygenase alpha subunits of PhDO and similar proteins including 3-chlorobenzoate 3; Region: Rieske_RO_Alpha_PhDO_like; cd03479 266264017766 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 266264017767 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 266264017768 hydrophobic ligand binding site; other site 266264017769 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 266264017770 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 266264017771 FMN-binding pocket [chemical binding]; other site 266264017772 flavin binding motif; other site 266264017773 phosphate binding motif [ion binding]; other site 266264017774 beta-alpha-beta structure motif; other site 266264017775 NAD binding pocket [chemical binding]; other site 266264017776 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 266264017777 catalytic loop [active] 266264017778 iron binding site [ion binding]; other site 266264017779 Transcriptional regulators [Transcription]; Region: FadR; COG2186 266264017780 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266264017781 DNA-binding site [nucleotide binding]; DNA binding site 266264017782 FCD domain; Region: FCD; pfam07729 266264017783 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 266264017784 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 266264017785 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 266264017786 CoA-transferase family III; Region: CoA_transf_3; pfam02515 266264017787 lipid-transfer protein; Provisional; Region: PRK07855 266264017788 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 266264017789 active site 266264017790 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 266264017791 DUF35 OB-fold domain; Region: DUF35; pfam01796 266264017792 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12843 266264017793 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 266264017794 CoA-transferase family III; Region: CoA_transf_3; pfam02515 266264017795 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 266264017796 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 266264017797 substrate binding site [chemical binding]; other site 266264017798 oxyanion hole (OAH) forming residues; other site 266264017799 trimer interface [polypeptide binding]; other site 266264017800 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cl00257 266264017801 IHF - DNA interface [nucleotide binding]; other site 266264017802 IHF dimer interface [polypeptide binding]; other site 266264017803 Nuclease-related domain; Region: NERD; pfam08378 266264017804 Part of AAA domain; Region: AAA_19; pfam13245 266264017805 potential protein location (hypothetical protein) that overlaps protein (hypothetical protein) 266264017806 potential protein location (hypothetical protein) that overlaps protein (hypothetical protein) 266264017807 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 266264017808 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 266264017809 non-specific DNA binding site [nucleotide binding]; other site 266264017810 salt bridge; other site 266264017811 sequence-specific DNA binding site [nucleotide binding]; other site 266264017812 H-NS histone family; Region: Histone_HNS; pfam00816 266264017813 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 266264017814 AAA domain; Region: AAA_13; pfam13166 266264017815 Helix-turn-helix domain; Region: HTH_17; cl17695 266264017816 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 266264017817 putative DNA binding site [nucleotide binding]; other site 266264017818 dimerization interface [polypeptide binding]; other site 266264017819 putative Zn2+ binding site [ion binding]; other site 266264017820 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266264017821 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266264017822 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 266264017823 putative effector binding pocket; other site 266264017824 dimerization interface [polypeptide binding]; other site 266264017825 Dyp-type peroxidase family; Region: Dyp_perox; pfam04261 266264017826 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 266264017827 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266264017828 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 266264017829 dimerization interface [polypeptide binding]; other site 266264017830 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 266264017831 Domain of unknown function (DUF1338); Region: DUF1338; pfam07063 266264017832 aminotransferase A; Validated; Region: PRK07683 266264017833 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 266264017834 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266264017835 homodimer interface [polypeptide binding]; other site 266264017836 catalytic residue [active] 266264017837 Uncharacterized ACR, COG1993; Region: DUF190; cl00872 266264017838 Peptidase propeptide and YPEB domain; Region: PepSY_2; pfam13670 266264017839 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 266264017840 Riboswitch candidate 266264017841 Riboswitch candidate 266264017842 D-amino acid dehydrogenase small subunit; Provisional; Region: PRK12409 266264017843 hydroxyglutarate oxidase; Provisional; Region: PRK11728 266264017844 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 266264017845 PAS fold; Region: PAS_4; pfam08448 266264017846 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 266264017847 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 266264017848 metal binding site [ion binding]; metal-binding site 266264017849 active site 266264017850 I-site; other site 266264017851 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266264017852 putative substrate translocation pore; other site 266264017853 Major Facilitator Superfamily; Region: MFS_1; pfam07690 266264017854 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 266264017855 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266264017856 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 266264017857 dimerization interface [polypeptide binding]; other site 266264017858 substrate binding pocket [chemical binding]; other site 266264017859 Putative catalytic domain, repeat 1, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_1; cd09111 266264017860 PLD-like domain; Region: PLDc_2; pfam13091 266264017861 putative active site [active] 266264017862 catalytic site [active] 266264017863 Putative catalytic domain, repeat 2, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_2; cd09113 266264017864 PLD-like domain; Region: PLDc_2; pfam13091 266264017865 putative active site [active] 266264017866 catalytic site [active] 266264017867 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 266264017868 Mechanosensitive ion channel; Region: MS_channel; pfam00924 266264017869 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 266264017870 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 266264017871 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266264017872 putative substrate translocation pore; other site 266264017873 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266264017874 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 266264017875 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 266264017876 HlyD family secretion protein; Region: HlyD_3; pfam13437 266264017877 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11552 266264017878 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 266264017879 Domain of unknown function (DUF1956); Region: DUF1956; pfam09209 266264017880 Outer membrane protein V [Cell envelope biogenesis, outer membrane]; Region: OmpV; COG3713 266264017881 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2945 266264017882 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 266264017883 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 266264017884 tetramer interface [polypeptide binding]; other site 266264017885 heme binding pocket [chemical binding]; other site 266264017886 NADPH binding site [chemical binding]; other site 266264017887 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 266264017888 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 266264017889 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 266264017890 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 266264017891 classical (c) SDRs; Region: SDR_c; cd05233 266264017892 NAD(P) binding site [chemical binding]; other site 266264017893 active site 266264017894 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 266264017895 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 266264017896 tetramer interface [polypeptide binding]; other site 266264017897 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266264017898 catalytic residue [active] 266264017899 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 266264017900 PAS domain; Region: PAS_9; pfam13426 266264017901 putative active site [active] 266264017902 heme pocket [chemical binding]; other site 266264017903 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 266264017904 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 266264017905 metal binding site [ion binding]; metal-binding site 266264017906 active site 266264017907 I-site; other site 266264017908 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 266264017909 HDOD domain; Region: HDOD; pfam08668 266264017910 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884 266264017911 active site clefts [active] 266264017912 zinc binding site [ion binding]; other site 266264017913 dimer interface [polypeptide binding]; other site 266264017914 DNA-binding transcriptional regulator CynR; Provisional; Region: PRK11242 266264017915 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266264017916 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator CynR, contains the type 2 periplasmic binding fold; Region: PBP2_CynR; cd08425 266264017917 dimerization interface [polypeptide binding]; other site 266264017918 metabolite-proton symporter; Region: 2A0106; TIGR00883 266264017919 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266264017920 putative substrate translocation pore; other site 266264017921 cytochrome o ubiquinol oxidase subunit II; Region: CyoA; TIGR01433 266264017922 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 266264017923 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 266264017924 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 266264017925 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 266264017926 D-pathway; other site 266264017927 Putative ubiquinol binding site [chemical binding]; other site 266264017928 Low-spin heme (heme b) binding site [chemical binding]; other site 266264017929 Putative water exit pathway; other site 266264017930 Binuclear center (heme o3/CuB) [ion binding]; other site 266264017931 K-pathway; other site 266264017932 Putative proton exit pathway; other site 266264017933 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 266264017934 Subunit I/III interface [polypeptide binding]; other site 266264017935 Subunit III/IV interface [polypeptide binding]; other site 266264017936 cytochrome o ubiquinol oxidase subunit IV; Region: CyoD; TIGR02847 266264017937 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 266264017938 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 266264017939 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 266264017940 dimerization interface [polypeptide binding]; other site 266264017941 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 266264017942 dimer interface [polypeptide binding]; other site 266264017943 putative CheW interface [polypeptide binding]; other site 266264017944 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266264017945 Major Facilitator Superfamily; Region: MFS_1; pfam07690 266264017946 putative substrate translocation pore; other site 266264017947 CDP-diacylglycerol pyrophosphatase; Provisional; Region: PRK05471 266264017948 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 266264017949 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 266264017950 active site lid residues [active] 266264017951 substrate binding pocket [chemical binding]; other site 266264017952 catalytic residues [active] 266264017953 substrate-Mg2+ binding site; other site 266264017954 aspartate-rich region 1; other site 266264017955 aspartate-rich region 2; other site 266264017956 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 266264017957 active site 266264017958 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 266264017959 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 266264017960 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 266264017961 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 266264017962 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 266264017963 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 266264017964 CoA-transferase family III; Region: CoA_transf_3; pfam02515 266264017965 enoyl-CoA hydratase; Provisional; Region: PRK06127 266264017966 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 266264017967 substrate binding site [chemical binding]; other site 266264017968 oxyanion hole (OAH) forming residues; other site 266264017969 trimer interface [polypeptide binding]; other site 266264017970 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3333 266264017971 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 266264017972 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 266264017973 Alanine-glyoxylate aminotransferase (AGAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to alanine-glyoxylate aminotransferase (AGAT); Region: AGAT_like; cd06451 266264017974 homodimer interface [polypeptide binding]; other site 266264017975 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266264017976 catalytic residue [active] 266264017977 Transcriptional regulators [Transcription]; Region: GntR; COG1802 266264017978 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266264017979 DNA-binding site [nucleotide binding]; DNA binding site 266264017980 FCD domain; Region: FCD; pfam07729 266264017981 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 266264017982 FAD binding domain; Region: FAD_binding_4; pfam01565 266264017983 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 266264017984 aromatic amino acid exporter; Provisional; Region: PRK11689 266264017985 potential protein location (hypothetical protein) that overlaps protein (conserved hypothetical protein) 266264017986 Protein related to penicillin acylase [General function prediction only]; Region: COG2366 266264017987 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 266264017988 Penicillin G acylase (PGA) belongs to a family of beta-lactam acylases that includes cephalosporin acylase (CA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_PGA_like; cd03747 266264017989 active site 266264017990 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 266264017991 Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369 266264017992 Flavodoxin; Region: Flavodoxin_1; pfam00258 266264017993 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 266264017994 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR_like1; cd06200 266264017995 FAD binding pocket [chemical binding]; other site 266264017996 FAD binding motif [chemical binding]; other site 266264017997 catalytic residues [active] 266264017998 NAD binding pocket [chemical binding]; other site 266264017999 phosphate binding motif [ion binding]; other site 266264018000 beta-alpha-beta structure motif; other site 266264018001 thiamine biosynthesis lipoprotein ApbE; Provisional; Region: PRK10461 266264018002 ApbE family; Region: ApbE; pfam02424 266264018003 Domain of unknown function (DUF4198); Region: DUF4198; pfam10670 266264018004 Predicted periplasmic protein (DUF2271); Region: DUF2271; pfam10029 266264018005 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3295 266264018006 PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172 266264018007 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 266264018008 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 266264018009 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 266264018010 dimer interface [polypeptide binding]; other site 266264018011 putative CheW interface [polypeptide binding]; other site 266264018012 flagellar capping protein; Reviewed; Region: fliD; PRK08032 266264018013 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 266264018014 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 266264018015 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 266264018016 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 266264018017 WHG domain; Region: WHG; pfam13305 266264018018 Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670 266264018019 Retinal pigment epithelial membrane protein; Region: RPE65; pfam03055 266264018020 NADP(H)-dependent alcohol dehydrogenases; Region: NADP_ADH; cd08285 266264018021 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 266264018022 tetramer interface [polypeptide binding]; other site 266264018023 catalytic Zn binding site [ion binding]; other site 266264018024 NADP binding site [chemical binding]; other site 266264018025 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 266264018026 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 266264018027 DNA binding residues [nucleotide binding] 266264018028 dimerization interface [polypeptide binding]; other site 266264018029 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 266264018030 Ligand Binding Site [chemical binding]; other site 266264018031 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 266264018032 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 266264018033 AsnC family; Region: AsnC_trans_reg; pfam01037 266264018034 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 266264018035 Uncharacterized conserved protein [Function unknown]; Region: COG5361 266264018036 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 266264018037 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3333 266264018038 Putative lumazine-binding; Region: Lumazine_bd_2; pfam12893 266264018039 Escherichia coli YegD, a putative chaperone protein, and related proteins; Region: YegD_like; cd10231 266264018040 putative chaperone; Provisional; Region: PRK11678 266264018041 nucleotide binding site [chemical binding]; other site 266264018042 putative NEF/HSP70 interaction site [polypeptide binding]; other site 266264018043 SBD interface [polypeptide binding]; other site 266264018044 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 266264018045 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 266264018046 metal binding site [ion binding]; metal-binding site 266264018047 active site 266264018048 I-site; other site 266264018049 Isochorismatase family; Region: Isochorismatase; pfam00857 266264018050 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 266264018051 catalytic triad [active] 266264018052 conserved cis-peptide bond; other site 266264018053 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with a PAS domain, a GGDEF (DiGuanylate-Cyclase (DGC) domain, and a DUF1 domain downstream. PAS domains have been found to bind ligands, and to act...; Region: CBS_pair_PAS_GGDEF_DUF1_assoc; cd04611 266264018054 FOG: CBS domain [General function prediction only]; Region: COG0517 266264018055 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with a PAS domain, a GGDEF (DiGuanylate-Cyclase (DGC) domain, and a DUF1 domain downstream. PAS domains have been found to bind ligands, and to act...; Region: CBS_pair_PAS_GGDEF_DUF1_assoc; cd04611 266264018056 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 266264018057 PAS domain; Region: PAS_9; pfam13426 266264018058 putative active site [active] 266264018059 heme pocket [chemical binding]; other site 266264018060 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 266264018061 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 266264018062 metal binding site [ion binding]; metal-binding site 266264018063 active site 266264018064 I-site; other site 266264018065 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 266264018066 PBP superfamily domain; Region: PBP_like_2; cl17296 266264018067 Protein of unknown function (DUF3761); Region: DUF3761; pfam12587 266264018068 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266264018069 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 266264018070 NAD(P) binding site [chemical binding]; other site 266264018071 active site 266264018072 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266264018073 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266264018074 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 266264018075 dimerization interface [polypeptide binding]; other site 266264018076 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 266264018077 Short C-terminal domain; Region: SHOCT; pfam09851 266264018078 Copper resistance protein D; Region: CopD; cl00563 266264018079 CopC domain; Region: CopC; pfam04234 266264018080 Copper resistance protein B precursor (CopB); Region: CopB; pfam05275 266264018081 copper-resistance protein, CopA family; Region: copper_res_A; TIGR01480 266264018082 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 266264018083 Multicopper oxidase; Region: Cu-oxidase; pfam00394 266264018084 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 266264018085 DNA-binding transcriptional activator CusR; Provisional; Region: PRK09836 266264018086 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266264018087 active site 266264018088 phosphorylation site [posttranslational modification] 266264018089 intermolecular recognition site; other site 266264018090 dimerization interface [polypeptide binding]; other site 266264018091 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 266264018092 DNA binding site [nucleotide binding] 266264018093 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 266264018094 HAMP domain; Region: HAMP; pfam00672 266264018095 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 266264018096 dimer interface [polypeptide binding]; other site 266264018097 phosphorylation site [posttranslational modification] 266264018098 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266264018099 ATP binding site [chemical binding]; other site 266264018100 Mg2+ binding site [ion binding]; other site 266264018101 G-X-G motif; other site 266264018102 Predicted transporter component [General function prediction only]; Region: COG2391 266264018103 Sulphur transport; Region: Sulf_transp; pfam04143 266264018104 Predicted transporter component [General function prediction only]; Region: COG2391 266264018105 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 266264018106 dimerization interface [polypeptide binding]; other site 266264018107 putative DNA binding site [nucleotide binding]; other site 266264018108 putative Zn2+ binding site [ion binding]; other site 266264018109 heavy metal cation tricomponent efflux pump (fragment) 266264018110 putative transposase OrfB; Reviewed; Region: PHA02517 266264018111 HTH-like domain; Region: HTH_21; pfam13276 266264018112 Integrase core domain; Region: rve; pfam00665 266264018113 Integrase core domain; Region: rve_3; pfam13683 266264018114 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 266264018115 Transposase; Region: HTH_Tnp_1; cl17663 266264018116 heavy metal cation tricomponent efflux pump (fragment) 266264018117 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 266264018118 HlyD family secretion protein; Region: HlyD_3; pfam13437 266264018119 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830 266264018120 Tfp pilus assembly protein PilE [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilE; COG4968 266264018121 Tfp pilus assembly protein PilV [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilV; COG4967 266264018122 Tfp pilus assembly protein PilW [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilW; COG4966 266264018123 Neisseria PilC beta-propeller domain; Region: Neisseria_PilC; pfam05567 266264018124 Domain of unknown function (DUF4382); Region: DUF4382; pfam14321 266264018125 Bacterial protein of unknown function (DUF899); Region: DUF899; pfam05988 266264018126 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 266264018127 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 266264018128 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 266264018129 extra-cytoplasmic solute receptor protein (fragment) 266264018130 Protein of unknown function (DUF465); Region: DUF465; cl01070 266264018131 Curli production assembly/transport component CsgG; Region: CsgG; cl17434 266264018132 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 266264018133 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 266264018134 DNA binding site [nucleotide binding] 266264018135 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 266264018136 amphipathic channel; other site 266264018137 Asn-Pro-Ala signature motifs; other site 266264018138 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 266264018139 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 266264018140 active site 266264018141 phosphorylation site [posttranslational modification] 266264018142 intermolecular recognition site; other site 266264018143 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 266264018144 DNA binding site [nucleotide binding] 266264018145 outer membrane protein OmpA (fragment) 266264018146 Outer membrane lipoprotein OmlA (small protein A) [Cell envelope biogenesis, outer membrane]; Region: OlmA; COG2913 266264018147 SmpA / OmlA family; Region: SmpA_OmlA; pfam04355 266264018148 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 266264018149 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 266264018150 substrate binding pocket [chemical binding]; other site 266264018151 membrane-bound complex binding site; other site 266264018152 hinge residues; other site 266264018153 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 266264018154 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 266264018155 substrate binding pocket [chemical binding]; other site 266264018156 membrane-bound complex binding site; other site 266264018157 hinge residues; other site 266264018158 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 266264018159 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 266264018160 putative active site [active] 266264018161 heme pocket [chemical binding]; other site 266264018162 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 266264018163 dimer interface [polypeptide binding]; other site 266264018164 phosphorylation site [posttranslational modification] 266264018165 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266264018166 ATP binding site [chemical binding]; other site 266264018167 Mg2+ binding site [ion binding]; other site 266264018168 G-X-G motif; other site 266264018169 Response regulator receiver domain; Region: Response_reg; pfam00072 266264018170 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266264018171 active site 266264018172 phosphorylation site [posttranslational modification] 266264018173 intermolecular recognition site; other site 266264018174 dimerization interface [polypeptide binding]; other site 266264018175 TPR repeat; Region: TPR_11; pfam13414 266264018176 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 266264018177 binding surface 266264018178 TPR motif; other site 266264018179 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 266264018180 binding surface 266264018181 TPR motif; other site 266264018182 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 266264018183 putative binding surface; other site 266264018184 active site 266264018185 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 266264018186 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266264018187 active site 266264018188 phosphorylation site [posttranslational modification] 266264018189 intermolecular recognition site; other site 266264018190 dimerization interface [polypeptide binding]; other site 266264018191 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 266264018192 DNA binding residues [nucleotide binding] 266264018193 dimerization interface [polypeptide binding]; other site 266264018194 serine protease protein (fragment) 266264018195 Helix-turn-helix domain; Region: HTH_38; pfam13936 266264018196 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 266264018197 Integrase core domain; Region: rve; pfam00665 266264018198 Extracellular protease precursor (fragment) 266264018199 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 266264018200 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 266264018201 trimer interface [polypeptide binding]; other site 266264018202 eyelet of channel; other site 266264018203 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 266264018204 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 266264018205 non-specific DNA binding site [nucleotide binding]; other site 266264018206 salt bridge; other site 266264018207 sequence-specific DNA binding site [nucleotide binding]; other site 266264018208 PAS domain; Region: PAS; smart00091 266264018209 PAS domain; Region: PAS_9; pfam13426 266264018210 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 266264018211 dimer interface [polypeptide binding]; other site 266264018212 phosphorylation site [posttranslational modification] 266264018213 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266264018214 ATP binding site [chemical binding]; other site 266264018215 Mg2+ binding site [ion binding]; other site 266264018216 G-X-G motif; other site 266264018217 Response regulator receiver domain; Region: Response_reg; pfam00072 266264018218 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266264018219 active site 266264018220 phosphorylation site [posttranslational modification] 266264018221 intermolecular recognition site; other site 266264018222 dimerization interface [polypeptide binding]; other site 266264018223 Right handed beta helix region; Region: Beta_helix; pfam13229 266264018224 Right handed beta helix region; Region: Beta_helix; pfam13229 266264018225 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 266264018226 putative trimer interface [polypeptide binding]; other site 266264018227 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 266264018228 trimer interface [polypeptide binding]; other site 266264018229 active site 266264018230 substrate binding site [chemical binding]; other site 266264018231 CoA binding site [chemical binding]; other site 266264018232 Capsule polysaccharide biosynthesis protein; Region: Capsule_synth; pfam05159 266264018233 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 266264018234 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 266264018235 Periplasmic protein involved in polysaccharide export, contains SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596 266264018236 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 266264018237 polysaccharide export inner-membrane protein, BexC/CtrB/KpsE family; Region: BexC_CtrB_KpsE; TIGR01010 266264018238 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 266264018239 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 266264018240 Walker A/P-loop; other site 266264018241 ATP binding site [chemical binding]; other site 266264018242 Q-loop/lid; other site 266264018243 ABC transporter signature motif; other site 266264018244 Walker B; other site 266264018245 D-loop; other site 266264018246 H-loop/switch region; other site 266264018247 ABC-2 type transporter; Region: ABC2_membrane; cl17235 266264018248 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK12457 266264018249 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 266264018250 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 266264018251 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 266264018252 Ligand binding site; other site 266264018253 oligomer interface; other site 266264018254 KpsF/GutQ family protein; Region: kpsF; TIGR00393 266264018255 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 266264018256 putative active site [active] 266264018257 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 266264018258 Capsule polysaccharide export protein [Cell envelope biogenesis, outer membrane]; Region: KpsC; COG3563 266264018259 Capsule polysaccharide export protein [Cell envelope biogenesis, outer membrane]; Region: KpsS; COG3562 266264018260 Capsule polysaccharide biosynthesis protein; Region: Capsule_synth; pfam05159 266264018261 Peptidase S8 family domain, uncharacterized subfamily 13; Region: Peptidases_S8_13; cd07496 266264018262 active site 266264018263 catalytic triad [active] 266264018264 Uncharacterized conserved protein [Function unknown]; Region: COG2128 266264018265 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 266264018266 Uncharacterized subfamily of medium-chain acyl-CoA synthetase (MACS); Region: MACS_like_1; cd05974 266264018267 active site 266264018268 acyl-activating enzyme (AAE) consensus motif; other site 266264018269 putative CoA binding site [chemical binding]; other site 266264018270 AMP binding site [chemical binding]; other site 266264018271 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 266264018272 metal binding site 2 [ion binding]; metal-binding site 266264018273 putative DNA binding helix; other site 266264018274 metal binding site 1 [ion binding]; metal-binding site 266264018275 dimer interface [polypeptide binding]; other site 266264018276 structural Zn2+ binding site [ion binding]; other site 266264018277 EamA-like transporter family; Region: EamA; pfam00892 266264018278 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 266264018279 EamA-like transporter family; Region: EamA; pfam00892 266264018280 Transcriptional regulator PadR-like family; Region: PadR; cl17335 266264018281 Predicted transcriptional regulators [Transcription]; Region: COG1695 266264018282 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 266264018283 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 266264018284 metal binding site [ion binding]; metal-binding site 266264018285 active site 266264018286 I-site; other site 266264018287 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 266264018288 Cache domain; Region: Cache_1; pfam02743 266264018289 HAMP domain; Region: HAMP; pfam00672 266264018290 PAS fold; Region: PAS_4; pfam08448 266264018291 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 266264018292 putative active site [active] 266264018293 heme pocket [chemical binding]; other site 266264018294 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 266264018295 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 266264018296 metal binding site [ion binding]; metal-binding site 266264018297 active site 266264018298 I-site; other site 266264018299 Cysteine-rich 4 helical bundle widely conserved in bacteria; Region: DUF326; cd08026 266264018300 dimerization interface [polypeptide binding]; other site 266264018301 fumarate hydratase (fumarase C),aerobic Class II (fragment) 266264018302 Helix-turn-helix domain; Region: HTH_38; pfam13936 266264018303 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 266264018304 Integrase core domain; Region: rve; pfam00665 266264018305 fumarate hydratase (fumarase C),aerobic Class II 266264018306 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 266264018307 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 266264018308 trimer interface [polypeptide binding]; other site 266264018309 eyelet of channel; other site 266264018310 citrate-proton symporter; Provisional; Region: PRK15075 266264018311 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266264018312 putative substrate translocation pore; other site 266264018313 Peptidase M14-like domain; uncharacterized subfamily; Region: M14-like_6; cd06233 266264018314 putative active site [active] 266264018315 Zn binding site [ion binding]; other site 266264018316 Peptidase C26; Region: Peptidase_C26; pfam07722 266264018317 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 266264018318 catalytic triad [active] 266264018319 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266264018320 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266264018321 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 266264018322 dimerization interface [polypeptide binding]; other site 266264018323 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 266264018324 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 266264018325 ligand binding site [chemical binding]; other site 266264018326 flexible hinge region; other site 266264018327 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 266264018328 non-specific DNA interactions [nucleotide binding]; other site 266264018329 DNA binding site [nucleotide binding] 266264018330 sequence specific DNA binding site [nucleotide binding]; other site 266264018331 putative cAMP binding site [chemical binding]; other site 266264018332 acyl-CoA synthetase; Validated; Region: PRK08162 266264018333 Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles and Arabidopsis; Region: ttLC_FACS_AEE21_like; cd12118 266264018334 acyl-activating enzyme (AAE) consensus motif; other site 266264018335 putative active site [active] 266264018336 AMP binding site [chemical binding]; other site 266264018337 putative CoA binding site [chemical binding]; other site 266264018338 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 266264018339 2-dehydropantoate 2-reductase; Provisional; Region: PRK12921 266264018340 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 266264018341 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 266264018342 enoyl-CoA hydratase; Provisional; Region: PRK06688 266264018343 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 266264018344 substrate binding site [chemical binding]; other site 266264018345 oxyanion hole (OAH) forming residues; other site 266264018346 trimer interface [polypeptide binding]; other site 266264018347 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762 266264018348 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 266264018349 MarR family; Region: MarR_2; pfam12802 266264018350 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cl17302 266264018351 flavin mononucleotide phosphatase; Provisional; Region: PRK10748 266264018352 Cupin domain; Region: Cupin_2; cl17218 266264018353 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 266264018354 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 266264018355 trimer interface [polypeptide binding]; other site 266264018356 eyelet of channel; other site 266264018357 CCC1-related family of proteins; Region: CCC1_like; cl00278 266264018358 Protein of unknown function, DUF485; Region: DUF485; pfam04341 266264018359 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 266264018360 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 266264018361 Na binding site [ion binding]; other site 266264018362 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 266264018363 Beta-lactamase; Region: Beta-lactamase; pfam00144 266264018364 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 266264018365 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 266264018366 catalytic residues [active] 266264018367 Protein of unknown function (DUF1059); Region: DUF1059; cl02284 266264018368 Heme/copper-type cytochrome/quinol oxidase, subunit 4 [Energy production and conversion]; Region: CyoD; COG3125 266264018369 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 266264018370 Subunit I/III interface [polypeptide binding]; other site 266264018371 Subunit III/IV interface [polypeptide binding]; other site 266264018372 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 266264018373 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 266264018374 D-pathway; other site 266264018375 Putative ubiquinol binding site [chemical binding]; other site 266264018376 Low-spin heme (heme b) binding site [chemical binding]; other site 266264018377 Putative water exit pathway; other site 266264018378 Binuclear center (heme o3/CuB) [ion binding]; other site 266264018379 K-pathway; other site 266264018380 Putative proton exit pathway; other site 266264018381 cytochrome o ubiquinol oxidase subunit II; Region: CyoA; TIGR01433 266264018382 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 266264018383 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 266264018384 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 266264018385 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266264018386 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 266264018387 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266264018388 homodimer interface [polypeptide binding]; other site 266264018389 catalytic residue [active] 266264018390 OPT oligopeptide transporter protein; Region: OPT; cl14607 266264018391 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 266264018392 Hydroxy(phenyl)pyruvate Reductase, D-isomer-specific 2-hydroxyacid-related dehydrogenase; Region: HPPR; cd12156 266264018393 putative ligand binding site [chemical binding]; other site 266264018394 NAD binding site [chemical binding]; other site 266264018395 catalytic site [active] 266264018396 His Kinase A (phosphoacceptor) domain; Region: HisKA; smart00388 266264018397 dimer interface [polypeptide binding]; other site 266264018398 phosphorylation site [posttranslational modification] 266264018399 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266264018400 ATP binding site [chemical binding]; other site 266264018401 Mg2+ binding site [ion binding]; other site 266264018402 G-X-G motif; other site 266264018403 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 266264018404 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266264018405 active site 266264018406 phosphorylation site [posttranslational modification] 266264018407 intermolecular recognition site; other site 266264018408 dimerization interface [polypeptide binding]; other site 266264018409 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 266264018410 DNA binding site [nucleotide binding] 266264018411 glucokinase; Provisional; Region: glk; PRK00292 266264018412 glucokinase, proteobacterial type; Region: glk; TIGR00749 266264018413 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 266264018414 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 266264018415 putative active site [active] 266264018416 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 266264018417 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 266264018418 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 266264018419 phosphogluconate dehydratase; Validated; Region: PRK09054 266264018420 6-phosphogluconate dehydratase; Region: edd; TIGR01196 266264018421 mechanosensitive channel MscS; Provisional; Region: PRK10334 266264018422 Conserved TM helix; Region: TM_helix; pfam05552 266264018423 Mechanosensitive ion channel; Region: MS_channel; pfam00924 266264018424 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 266264018425 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 266264018426 H+ Antiporter protein; Region: 2A0121; TIGR00900 266264018427 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266264018428 putative substrate translocation pore; other site 266264018429 Outer membrane receptor for Fe3+-dicitrate [Inorganic ion transport and metabolism]; Region: FecA; COG4772 266264018430 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 266264018431 N-terminal plug; other site 266264018432 ligand-binding site [chemical binding]; other site 266264018433 hypothetical protein 266264018434 Outer membrane receptor for Fe3+-dicitrate [Inorganic ion transport and metabolism]; Region: FecA; COG4772 266264018435 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 266264018436 N-terminal plug; other site 266264018437 ligand-binding site [chemical binding]; other site 266264018438 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 266264018439 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 266264018440 G1 box; other site 266264018441 putative GEF interaction site [polypeptide binding]; other site 266264018442 GTP/Mg2+ binding site [chemical binding]; other site 266264018443 Switch I region; other site 266264018444 G2 box; other site 266264018445 G3 box; other site 266264018446 Switch II region; other site 266264018447 G4 box; other site 266264018448 G5 box; other site 266264018449 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 266264018450 Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295 266264018451 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 266264018452 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 266264018453 Walker A motif; other site 266264018454 ATP binding site [chemical binding]; other site 266264018455 Walker B motif; other site 266264018456 arginine finger; other site 266264018457 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 266264018458 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 266264018459 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 266264018460 DNA-binding site [nucleotide binding]; DNA binding site 266264018461 RNA-binding motif; other site