-- dump date 20140619_052159 -- class Genbank::misc_feature -- table misc_feature_note -- id note 1089446000001 chromosomal replication initiation protein; Provisional; Region: dnaA; PRK14086 1089446000002 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1089446000003 Walker A motif; other site 1089446000004 ATP binding site [chemical binding]; other site 1089446000005 Walker B motif; other site 1089446000006 arginine finger; other site 1089446000007 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 1089446000008 DnaA box-binding interface [nucleotide binding]; other site 1089446000009 DNA polymerase III subunit beta; Validated; Region: PRK07761 1089446000010 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 1089446000011 putative DNA binding surface [nucleotide binding]; other site 1089446000012 dimer interface [polypeptide binding]; other site 1089446000013 beta-clamp/clamp loader binding surface; other site 1089446000014 beta-clamp/translesion DNA polymerase binding surface; other site 1089446000015 recombination protein F; Reviewed; Region: recF; PRK00064 1089446000016 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 1089446000017 Walker A/P-loop; other site 1089446000018 ATP binding site [chemical binding]; other site 1089446000019 Q-loop/lid; other site 1089446000020 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1089446000021 ABC transporter signature motif; other site 1089446000022 Walker B; other site 1089446000023 D-loop; other site 1089446000024 H-loop/switch region; other site 1089446000025 hypothetical protein; Provisional; Region: PRK00111 1089446000026 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 1089446000027 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1089446000028 ATP binding site [chemical binding]; other site 1089446000029 Mg2+ binding site [ion binding]; other site 1089446000030 G-X-G motif; other site 1089446000031 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1089446000032 anchoring element; other site 1089446000033 dimer interface [polypeptide binding]; other site 1089446000034 ATP binding site [chemical binding]; other site 1089446000035 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 1089446000036 active site 1089446000037 putative metal-binding site [ion binding]; other site 1089446000038 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1089446000039 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 1089446000040 metal binding site [ion binding]; metal-binding site 1089446000041 DNA gyrase subunit A; Validated; Region: PRK05560 1089446000042 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 1089446000043 CAP-like domain; other site 1089446000044 active site 1089446000045 primary dimer interface [polypeptide binding]; other site 1089446000046 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1089446000047 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1089446000048 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1089446000049 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1089446000050 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1089446000051 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1089446000052 Transmembrane domain of unknown function (DUF3566); Region: DUF3566; pfam12089 1089446000053 YwiC-like protein; Region: YwiC; pfam14256 1089446000054 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_4; cd06312 1089446000055 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 1089446000056 putative ligand binding site [chemical binding]; other site 1089446000057 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1089446000058 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1089446000059 TM-ABC transporter signature motif; other site 1089446000060 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 1089446000061 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1089446000062 Walker A/P-loop; other site 1089446000063 ATP binding site [chemical binding]; other site 1089446000064 Q-loop/lid; other site 1089446000065 ABC transporter signature motif; other site 1089446000066 Walker B; other site 1089446000067 D-loop; other site 1089446000068 H-loop/switch region; other site 1089446000069 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 1089446000070 active site 1089446000071 Rhomboid family; Region: Rhomboid; pfam01694 1089446000072 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I-E; cl17348 1089446000073 CRISPR-associated protein (Cas_Cas5); Region: Cas_Cas5d; pfam09704 1089446000074 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 1089446000075 Glycerophosphodiester phosphodiesterase-like domain of spider venom sphingomyelinases D, bacterial phospholipase D, and similar proteins; Region: GDPD_like_SMaseD_PLD; cd08576 1089446000076 putative active site [active] 1089446000077 catalytic site [active] 1089446000078 Mg binding site [ion binding]; other site 1089446000079 catalytic loop [active] 1089446000080 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1089446000081 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1089446000082 Walker A/P-loop; other site 1089446000083 ATP binding site [chemical binding]; other site 1089446000084 Q-loop/lid; other site 1089446000085 ABC transporter signature motif; other site 1089446000086 Walker B; other site 1089446000087 D-loop; other site 1089446000088 H-loop/switch region; other site 1089446000089 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 1089446000090 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1089446000091 ABC-ATPase subunit interface; other site 1089446000092 dimer interface [polypeptide binding]; other site 1089446000093 putative PBP binding regions; other site 1089446000094 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1089446000095 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1089446000096 ABC-ATPase subunit interface; other site 1089446000097 dimer interface [polypeptide binding]; other site 1089446000098 putative PBP binding regions; other site 1089446000099 iron-dicitrate transporter substrate-binding subunit; Provisional; Region: fecB; PRK11411 1089446000100 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 1089446000101 siderophore binding site; other site 1089446000102 putative septation inhibitor protein; Reviewed; Region: PRK00159 1089446000103 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1089446000104 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1089446000105 active site 1089446000106 ATP binding site [chemical binding]; other site 1089446000107 substrate binding site [chemical binding]; other site 1089446000108 activation loop (A-loop); other site 1089446000109 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 1089446000110 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1089446000111 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1089446000112 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1089446000113 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1089446000114 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1089446000115 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1089446000116 active site 1089446000117 ATP binding site [chemical binding]; other site 1089446000118 substrate binding site [chemical binding]; other site 1089446000119 activation loop (A-loop); other site 1089446000120 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1089446000121 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1089446000122 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 1089446000123 Protein phosphatase 2C; Region: PP2C; pfam00481 1089446000124 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 1089446000125 active site 1089446000126 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1089446000127 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1089446000128 phosphopeptide binding site; other site 1089446000129 Protein of unknown function (DUF2662); Region: DUF3662; pfam12401 1089446000130 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1089446000131 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1089446000132 phosphopeptide binding site; other site 1089446000133 CAAX protease self-immunity; Region: Abi; pfam02517 1089446000134 Protein of unknown function (DUF2812); Region: DUF2812; pfam11193 1089446000135 Predicted transcriptional regulators [Transcription]; Region: COG1695 1089446000136 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 1089446000137 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 1089446000138 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1089446000139 intersubunit interface [polypeptide binding]; other site 1089446000140 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1089446000141 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1089446000142 Walker A/P-loop; other site 1089446000143 ATP binding site [chemical binding]; other site 1089446000144 Q-loop/lid; other site 1089446000145 ABC transporter signature motif; other site 1089446000146 Walker B; other site 1089446000147 D-loop; other site 1089446000148 H-loop/switch region; other site 1089446000149 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1089446000150 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1089446000151 ABC-ATPase subunit interface; other site 1089446000152 dimer interface [polypeptide binding]; other site 1089446000153 putative PBP binding regions; other site 1089446000154 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 1089446000155 MgtE intracellular N domain; Region: MgtE_N; smart00924 1089446000156 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 1089446000157 Divalent cation transporter; Region: MgtE; pfam01769 1089446000158 trehalose synthase; Region: treS_nterm; TIGR02456 1089446000159 Alpha amylase catalytic domain found in an uncharacterized protein family; Region: AmyAc_2; cd11348 1089446000160 active site 1089446000161 catalytic site [active] 1089446000162 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 1089446000163 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1089446000164 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1089446000165 putative substrate translocation pore; other site 1089446000166 Anti-sigma-K factor rskA; Region: RskA; pfam10099 1089446000167 RNA polymerase sigma factor SigK; Reviewed; Region: PRK09646 1089446000168 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1089446000169 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1089446000170 DNA binding residues [nucleotide binding] 1089446000171 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 1089446000172 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 1089446000173 TlpA-like family, DipZ-like subfamily; composed uncharacterized proteins containing a TlpA-like TRX domain. Some members show domain architectures similar to that of E. coli DipZ protein (also known as DsbD). The only eukaryotic members of the TlpA...; Region: TlpA_like_DipZ_like; cd03012 1089446000174 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1089446000175 catalytic residues [active] 1089446000176 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1089446000177 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1089446000178 dimer interface [polypeptide binding]; other site 1089446000179 conserved gate region; other site 1089446000180 putative PBP binding loops; other site 1089446000181 ABC-ATPase subunit interface; other site 1089446000182 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 1089446000183 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1089446000184 Walker A/P-loop; other site 1089446000185 ATP binding site [chemical binding]; other site 1089446000186 Q-loop/lid; other site 1089446000187 ABC transporter signature motif; other site 1089446000188 Walker B; other site 1089446000189 D-loop; other site 1089446000190 H-loop/switch region; other site 1089446000191 MT0933-like antitoxin protein; Region: MT0933_antitox; pfam14013 1089446000192 M20 Peptidase, carboxypeptidase yscS-like; Region: M20_yscS_like; cd05675 1089446000193 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624 1089446000194 putative metal binding site [ion binding]; other site 1089446000195 biotin synthase; Validated; Region: PRK06256 1089446000196 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1089446000197 FeS/SAM binding site; other site 1089446000198 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 1089446000199 MepB protein; Region: MepB; cl01985 1089446000200 AMP nucleosidase; Provisional; Region: PRK08292 1089446000201 Bacterial AMP nucleoside phosphorylase N-terminus; Region: AMNp_N; pfam10423 1089446000202 Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775 1089446000203 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cd00599 1089446000204 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 1089446000205 active site 1089446000206 Myo-inositol-1-phosphate synthase [Lipid metabolism]; Region: INO1; COG1260 1089446000207 Myo-inositol-1-phosphate synthase; Region: NAD_binding_5; cl00554 1089446000208 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_1; cd02432 1089446000209 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 1089446000210 Lipase (class 2); Region: Lipase_2; pfam01674 1089446000211 NADPH_oxidase. Nitroreductase family containing NADH oxidase and other, uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and nitroimidazoles; Region: NADH_oxidase; cd03370 1089446000212 dimer interface [polypeptide binding]; other site 1089446000213 FMN binding site [chemical binding]; other site 1089446000214 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 1089446000215 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 1089446000216 trimer interface [polypeptide binding]; other site 1089446000217 putative metal binding site [ion binding]; other site 1089446000218 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1089446000219 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 1089446000220 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 1089446000221 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 1089446000222 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1089446000223 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1089446000224 Coenzyme A binding pocket [chemical binding]; other site 1089446000225 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 1089446000226 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4805 1089446000227 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1089446000228 MarR family; Region: MarR; pfam01047 1089446000229 Putative ammonia monooxygenase [General function prediction only]; Region: AbrB; COG3180 1089446000230 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 1089446000231 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 1089446000232 hypothetical protein; Provisional; Region: PRK10621 1089446000233 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1089446000234 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1089446000235 active site 1089446000236 phosphorylation site [posttranslational modification] 1089446000237 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 1089446000238 active site 1089446000239 P-loop; other site 1089446000240 phosphorylation site [posttranslational modification] 1089446000241 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: ulaA; PRK09410 1089446000242 HrpA-like helicases [DNA replication, recombination, and repair]; Region: HrpA; COG1643 1089446000243 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1089446000244 ATP binding site [chemical binding]; other site 1089446000245 putative Mg++ binding site [ion binding]; other site 1089446000246 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1089446000247 nucleotide binding region [chemical binding]; other site 1089446000248 ATP-binding site [chemical binding]; other site 1089446000249 Helicase associated domain (HA2); Region: HA2; pfam04408 1089446000250 ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482 1089446000251 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_2; pfam13532 1089446000252 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 1089446000253 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 1089446000254 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1089446000255 NAD(P) binding site [chemical binding]; other site 1089446000256 active site 1089446000257 Putative heavy-metal-binding; Region: YbjQ_1; cl00426 1089446000258 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1089446000259 RNA binding surface [nucleotide binding]; other site 1089446000260 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 1089446000261 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1089446000262 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 1089446000263 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1089446000264 DNA binding site [nucleotide binding] 1089446000265 active site 1089446000266 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1089446000267 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1089446000268 active site 1089446000269 glycerol kinase; Provisional; Region: glpK; PRK00047 1089446000270 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1089446000271 nucleotide binding site [chemical binding]; other site 1089446000272 Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580 1089446000273 amphipathic channel; other site 1089446000274 Asn-Pro-Ala signature motifs; other site 1089446000275 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 1089446000276 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 1089446000277 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 1089446000278 active site 1089446000279 Zn binding site [ion binding]; other site 1089446000280 Protease prsW family; Region: PrsW-protease; pfam13367 1089446000281 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 1089446000282 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 1089446000283 Mycobacterial cell wall arabinan synthesis protein; Region: Arabinose_trans; pfam04602 1089446000284 Arabinofuranosyltransferase N terminal; Region: AftA_N; pfam12250 1089446000285 Arabinofuranosyltransferase A C terminal; Region: AftA_C; pfam12249 1089446000286 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 1089446000287 classical (c) SDRs; Region: SDR_c; cd05233 1089446000288 NAD(P) binding site [chemical binding]; other site 1089446000289 active site 1089446000290 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1089446000291 FAD binding domain; Region: FAD_binding_4; pfam01565 1089446000292 D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030 1089446000293 Predicted membrane protein [Function unknown]; Region: COG2246 1089446000294 GtrA-like protein; Region: GtrA; pfam04138 1089446000295 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 1089446000296 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1089446000297 active site 1089446000298 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1089446000299 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 1089446000300 intersubunit interface [polypeptide binding]; other site 1089446000301 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 1089446000302 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 1089446000303 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 1089446000304 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 1089446000305 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1089446000306 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1089446000307 ABC-ATPase subunit interface; other site 1089446000308 dimer interface [polypeptide binding]; other site 1089446000309 putative PBP binding regions; other site 1089446000310 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1089446000311 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 1089446000312 intersubunit interface [polypeptide binding]; other site 1089446000313 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 1089446000314 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1089446000315 active site 1089446000316 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 1089446000317 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 1089446000318 Walker A/P-loop; other site 1089446000319 ATP binding site [chemical binding]; other site 1089446000320 Q-loop/lid; other site 1089446000321 ABC transporter signature motif; other site 1089446000322 Walker B; other site 1089446000323 D-loop; other site 1089446000324 H-loop/switch region; other site 1089446000325 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 1089446000326 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1089446000327 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1089446000328 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1089446000329 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 1089446000330 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 1089446000331 NAD(P) binding site [chemical binding]; other site 1089446000332 histidinol-phosphate aminotransferase; Validated; Region: PRK02731 1089446000333 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1089446000334 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1089446000335 homodimer interface [polypeptide binding]; other site 1089446000336 catalytic residue [active] 1089446000337 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 1089446000338 transmembrane helices; other site 1089446000339 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 1089446000340 CAT RNA binding domain; Region: CAT_RBD; smart01061 1089446000341 PRD domain; Region: PRD; pfam00874 1089446000342 PRD domain; Region: PRD; pfam00874 1089446000343 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 1089446000344 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1089446000345 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 1089446000346 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1089446000347 Nitric oxide reductase large subunit [Inorganic ion transport and metabolism]; Region: NorB; COG3256 1089446000348 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1089446000349 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1089446000350 DNA-binding site [nucleotide binding]; DNA binding site 1089446000351 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1089446000352 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1089446000353 homodimer interface [polypeptide binding]; other site 1089446000354 catalytic residue [active] 1089446000355 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 1089446000356 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 1089446000357 active site 1089446000358 multimer interface [polypeptide binding]; other site 1089446000359 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 1089446000360 predicted active site [active] 1089446000361 catalytic triad [active] 1089446000362 prephenate dehydrogenase; Validated; Region: PRK06545 1089446000363 prephenate dehydrogenase; Validated; Region: PRK08507 1089446000364 putative tRNA adenosine deaminase-associated protein; Region: tRNA_deam_assoc; TIGR03941 1089446000365 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 1089446000366 nucleoside/Zn binding site; other site 1089446000367 dimer interface [polypeptide binding]; other site 1089446000368 catalytic motif [active] 1089446000369 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 1089446000370 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 1089446000371 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; cl00409 1089446000372 glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710 1089446000373 tRNA synthetases class I (E and Q), catalytic domain; Region: tRNA-synt_1c; pfam00749 1089446000374 active site 1089446000375 KMSKS motif; other site 1089446000376 fructuronate transporter; Provisional; Region: PRK10034; cl15264 1089446000377 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 1089446000378 Shikimate kinase; Region: SKI; pfam01202 1089446000379 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 1089446000380 L-idonate 5-dehydrogenase; Provisional; Region: PRK09880 1089446000381 L-idonate 5-dehydrogenase; Region: idonate-5-DH; cd08232 1089446000382 putative NAD(P) binding site [chemical binding]; other site 1089446000383 catalytic Zn binding site [ion binding]; other site 1089446000384 gluconate 5-dehydrogenase; Provisional; Region: PRK08085 1089446000385 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 1089446000386 NADP binding site [chemical binding]; other site 1089446000387 homodimer interface [polypeptide binding]; other site 1089446000388 active site 1089446000389 Alanine-glyoxylate amino-transferase; Region: Aminotran_MocR; pfam12897 1089446000390 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1089446000391 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1089446000392 homodimer interface [polypeptide binding]; other site 1089446000393 catalytic residue [active] 1089446000394 Suppressor of fused protein (SUFU); Region: SUFU; pfam05076 1089446000395 DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397 1089446000396 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1089446000397 Walker A motif; other site 1089446000398 ATP binding site [chemical binding]; other site 1089446000399 Walker B motif; other site 1089446000400 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1089446000401 arginine finger; other site 1089446000402 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 1089446000403 hypothetical protein; Validated; Region: PRK00153 1089446000404 recombination protein RecR; Reviewed; Region: recR; PRK00076 1089446000405 Helix-hairpin-helix DNA-binding motif class 1; Region: HhH1; smart00278 1089446000406 RecR protein; Region: RecR; pfam02132 1089446000407 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 1089446000408 putative active site [active] 1089446000409 putative metal-binding site [ion binding]; other site 1089446000410 tetramer interface [polypeptide binding]; other site 1089446000411 putative transporter; Provisional; Region: PRK09821 1089446000412 GntP family permease; Region: GntP_permease; pfam02447 1089446000413 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 1089446000414 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1089446000415 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395 1089446000416 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1089446000417 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1089446000418 DNA-binding site [nucleotide binding]; DNA binding site 1089446000419 FCD domain; Region: FCD; pfam07729 1089446000420 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 1089446000421 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1089446000422 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 1089446000423 catalytic triad [active] 1089446000424 UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769 1089446000425 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1089446000426 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 1089446000427 DNA polymerase III subunit epsilon; Validated; Region: PRK05601 1089446000428 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 1089446000429 active site 1089446000430 catalytic site [active] 1089446000431 substrate binding site [chemical binding]; other site 1089446000432 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cl00038 1089446000433 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 1089446000434 dimer interface [polypeptide binding]; other site 1089446000435 FMN binding site [chemical binding]; other site 1089446000436 NADPH bind site [chemical binding]; other site 1089446000437 2-isopropylmalate synthase; Validated; Region: PRK03739 1089446000438 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 1089446000439 active site 1089446000440 catalytic residues [active] 1089446000441 metal binding site [ion binding]; metal-binding site 1089446000442 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 1089446000443 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 1089446000444 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1089446000445 DNA binding residues [nucleotide binding] 1089446000446 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 1089446000447 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 1089446000448 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1089446000449 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1089446000450 putative substrate translocation pore; other site 1089446000451 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 1089446000452 intersubunit interface [polypeptide binding]; other site 1089446000453 active site 1089446000454 catalytic residue [active] 1089446000455 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 1089446000456 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 1089446000457 active site 1089446000458 substrate binding site [chemical binding]; other site 1089446000459 metal binding site [ion binding]; metal-binding site 1089446000460 TQXA domain; Region: TQXA_dom; TIGR03934 1089446000461 Cna protein B-type domain; Region: Cna_B; pfam05738 1089446000462 Cna protein B-type domain; Region: Cna_B; pfam05738 1089446000463 Cna protein B-type domain; Region: Cna_B; pfam05738 1089446000464 aspartate kinase; Reviewed; Region: PRK06635 1089446000465 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 1089446000466 putative nucleotide binding site [chemical binding]; other site 1089446000467 putative catalytic residues [active] 1089446000468 putative Mg ion binding site [ion binding]; other site 1089446000469 putative aspartate binding site [chemical binding]; other site 1089446000470 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 1089446000471 putative allosteric regulatory site; other site 1089446000472 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 1089446000473 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 1089446000474 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1089446000475 RNA polymerase sigma factor; Provisional; Region: PRK12535 1089446000476 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1089446000477 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 1089446000478 DNA binding residues [nucleotide binding] 1089446000479 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 1089446000480 Catalase-like heme-binding proteins and protein domains; Region: catalase_like; cl09506 1089446000481 heme binding pocket [chemical binding]; other site 1089446000482 Protein of unknown function (DUF1549); Region: PSCyt2; pfam07583 1089446000483 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 1089446000484 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 1089446000485 Walker A/P-loop; other site 1089446000486 ATP binding site [chemical binding]; other site 1089446000487 Q-loop/lid; other site 1089446000488 ABC transporter signature motif; other site 1089446000489 Walker B; other site 1089446000490 D-loop; other site 1089446000491 H-loop/switch region; other site 1089446000492 TOBE domain; Region: TOBE_2; pfam08402 1089446000493 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1089446000494 dimer interface [polypeptide binding]; other site 1089446000495 conserved gate region; other site 1089446000496 ABC-ATPase subunit interface; other site 1089446000497 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 1089446000498 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1089446000499 Sugar phosphate permease [Carbohydrate transport and metabolism]; Region: UhpC; COG2271 1089446000500 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1089446000501 putative substrate translocation pore; other site 1089446000502 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1089446000503 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1089446000504 active site 1089446000505 phosphorylation site [posttranslational modification] 1089446000506 intermolecular recognition site; other site 1089446000507 dimerization interface [polypeptide binding]; other site 1089446000508 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1089446000509 DNA binding site [nucleotide binding] 1089446000510 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1089446000511 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1089446000512 dimer interface [polypeptide binding]; other site 1089446000513 phosphorylation site [posttranslational modification] 1089446000514 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1089446000515 ATP binding site [chemical binding]; other site 1089446000516 Mg2+ binding site [ion binding]; other site 1089446000517 G-X-G motif; other site 1089446000518 putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12674 1089446000519 putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK12612 1089446000520 putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK12654 1089446000521 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK08375 1089446000522 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1089446000523 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK07375 1089446000524 putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12650 1089446000525 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1089446000526 Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111 1089446000527 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 1089446000528 Predicted membrane protein [Function unknown]; Region: COG1511 1089446000529 Predicted membrane protein [Function unknown]; Region: COG1511 1089446000530 Domain of unknown function (DUF4185); Region: DUF4185; pfam13810 1089446000531 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 1089446000532 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 1089446000533 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1089446000534 Walker A/P-loop; other site 1089446000535 ATP binding site [chemical binding]; other site 1089446000536 Q-loop/lid; other site 1089446000537 ABC transporter signature motif; other site 1089446000538 Walker B; other site 1089446000539 D-loop; other site 1089446000540 H-loop/switch region; other site 1089446000541 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1089446000542 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1089446000543 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 1089446000544 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 1089446000545 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1089446000546 putative active site [active] 1089446000547 putative metal binding site [ion binding]; other site 1089446000548 Yqey-like protein; Region: YqeY; pfam09424 1089446000549 Transglycosylase; Region: Transgly; pfam00912 1089446000550 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 1089446000551 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1089446000552 PASTA domain; Region: PASTA; pfam03793 1089446000553 Transcription factor WhiB; Region: Whib; pfam02467 1089446000554 Domain of unknown function (DUF4177); Region: DUF4177; pfam13783 1089446000555 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 1089446000556 homotrimer interaction site [polypeptide binding]; other site 1089446000557 putative active site [active] 1089446000558 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 1089446000559 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1089446000560 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1089446000561 ligand binding site [chemical binding]; other site 1089446000562 flexible hinge region; other site 1089446000563 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1089446000564 putative switch regulator; other site 1089446000565 non-specific DNA interactions [nucleotide binding]; other site 1089446000566 DNA binding site [nucleotide binding] 1089446000567 sequence specific DNA binding site [nucleotide binding]; other site 1089446000568 putative cAMP binding site [chemical binding]; other site 1089446000569 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 1089446000570 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1089446000571 minor groove reading motif; other site 1089446000572 helix-hairpin-helix signature motif; other site 1089446000573 substrate binding pocket [chemical binding]; other site 1089446000574 active site 1089446000575 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 1089446000576 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 1089446000577 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1089446000578 catalytic residues [active] 1089446000579 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 1089446000580 putative active site [active] 1089446000581 putative CoA binding site [chemical binding]; other site 1089446000582 nudix motif; other site 1089446000583 metal binding site [ion binding]; metal-binding site 1089446000584 Colicin V production protein; Region: Colicin_V; pfam02674 1089446000585 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 1089446000586 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1089446000587 active site 1089446000588 substrate binding sites [chemical binding]; other site 1089446000589 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1089446000590 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1089446000591 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 1089446000592 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1089446000593 motif II; other site 1089446000594 helicase/secretion neighborhood CpaE-like protein; Region: CpaE_hom_Actino; TIGR03815 1089446000595 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 1089446000596 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 1089446000597 ATP binding site [chemical binding]; other site 1089446000598 Walker A motif; other site 1089446000599 hexamer interface [polypeptide binding]; other site 1089446000600 Walker B motif; other site 1089446000601 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 1089446000602 Protein of unknown function (DUF4244); Region: DUF4244; pfam14029 1089446000603 helicase/secretion neighborhood TadE-like protein; Region: tadE_like_DECH; TIGR03816 1089446000604 helicase/secretion neighborhood putative DEAH-box helicase; Region: DECH_helic; TIGR03817 1089446000605 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1089446000606 ATP binding site [chemical binding]; other site 1089446000607 putative Mg++ binding site [ion binding]; other site 1089446000608 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1089446000609 nucleotide binding region [chemical binding]; other site 1089446000610 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 1089446000611 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1089446000612 DNA-binding site [nucleotide binding]; DNA binding site 1089446000613 RNA-binding motif; other site 1089446000614 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 1089446000615 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 1089446000616 active site 1089446000617 interdomain interaction site; other site 1089446000618 putative metal-binding site [ion binding]; other site 1089446000619 nucleotide binding site [chemical binding]; other site 1089446000620 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 1089446000621 domain I; other site 1089446000622 DNA binding groove [nucleotide binding] 1089446000623 phosphate binding site [ion binding]; other site 1089446000624 domain II; other site 1089446000625 domain III; other site 1089446000626 nucleotide binding site [chemical binding]; other site 1089446000627 catalytic site [active] 1089446000628 domain IV; other site 1089446000629 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 1089446000630 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 1089446000631 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 1089446000632 Predicted membrane protein [Function unknown]; Region: COG1297 1089446000633 putative oligopeptide transporter, OPT family; Region: TIGR00733 1089446000634 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1089446000635 dimerization interface [polypeptide binding]; other site 1089446000636 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1089446000637 cyclase homology domain; Region: CHD; cd07302 1089446000638 nucleotidyl binding site; other site 1089446000639 metal binding site [ion binding]; metal-binding site 1089446000640 dimer interface [polypeptide binding]; other site 1089446000641 DNA polymerase III subunit delta'; Validated; Region: PRK07940 1089446000642 DNA polymerase III subunit delta'; Validated; Region: PRK08485 1089446000643 acyl-CoA synthetase; Validated; Region: PRK07788 1089446000644 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1089446000645 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1089446000646 acyl-activating enzyme (AAE) consensus motif; other site 1089446000647 acyl-activating enzyme (AAE) consensus motif; other site 1089446000648 AMP binding site [chemical binding]; other site 1089446000649 active site 1089446000650 CoA binding site [chemical binding]; other site 1089446000651 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 1089446000652 active site 1089446000653 catalytic triad [active] 1089446000654 oxyanion hole [active] 1089446000655 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 1089446000656 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 1089446000657 substrate binding site; other site 1089446000658 tetramer interface; other site 1089446000659 dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfbC; COG1898 1089446000660 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 1089446000661 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 1089446000662 NADP binding site [chemical binding]; other site 1089446000663 active site 1089446000664 putative substrate binding site [chemical binding]; other site 1089446000665 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 1089446000666 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 1089446000667 NAD binding site [chemical binding]; other site 1089446000668 substrate binding site [chemical binding]; other site 1089446000669 homodimer interface [polypeptide binding]; other site 1089446000670 active site 1089446000671 Peptidase M1 family Aminopeptidase N; Region: M1_APN_4; cd09603 1089446000672 Zn binding site [ion binding]; other site 1089446000673 Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505 1089446000674 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1089446000675 Putative esterase; Region: Esterase; pfam00756 1089446000676 Peptidase family S64; Region: Peptidase_S64; pfam08192 1089446000677 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK07818 1089446000678 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 1089446000679 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1089446000680 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1089446000681 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1089446000682 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1089446000683 non-specific DNA binding site [nucleotide binding]; other site 1089446000684 salt bridge; other site 1089446000685 sequence-specific DNA binding site [nucleotide binding]; other site 1089446000686 Predicted transcriptional regulator [General function prediction only]; Region: COG3800 1089446000687 Domain of unknown function (DUF955); Region: DUF955; pfam06114 1089446000688 Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856 1089446000689 Succinate:quinone oxidoreductase (SQR)-like Type B subfamily 2, transmembrane subunit; composed of proteins with similarity to the SQRs of Geobacter metallireducens and Corynebacterium glutamicum. SQR catalyzes the oxidation of succinate to fumarate...; Region: SQR_TypeB_2_TM; cd03498 1089446000690 succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046 1089446000691 putative Iron-sulfur protein interface [polypeptide binding]; other site 1089446000692 proximal heme binding site [chemical binding]; other site 1089446000693 distal heme binding site [chemical binding]; other site 1089446000694 putative dimer interface [polypeptide binding]; other site 1089446000695 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07573 1089446000696 L-aspartate oxidase; Provisional; Region: PRK06175 1089446000697 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1089446000698 succinate dehydrogenase/fumarate reductase iron-sulfur subunit; Validated; Region: PRK07570 1089446000699 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 1089446000700 Predicted membrane protein [Function unknown]; Region: COG2733 1089446000701 Protein of unknown function (DUF2516); Region: DUF2516; pfam10724 1089446000702 Class I aldolases; Region: Aldolase_Class_I; cl17187 1089446000703 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 1089446000704 pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493 1089446000705 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1089446000706 FeS/SAM binding site; other site 1089446000707 autonomous glycyl radical cofactor GrcA; Provisional; Region: PRK11127 1089446000708 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 1089446000709 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 1089446000710 Protein of unknown function (DUF2505); Region: DUF2505; pfam10698 1089446000711 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13903 1089446000712 FAD binding domain; Region: FAD_binding_4; pfam01565 1089446000713 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 1089446000714 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK05605 1089446000715 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 1089446000716 acyl-activating enzyme (AAE) consensus motif; other site 1089446000717 putative AMP binding site [chemical binding]; other site 1089446000718 putative active site [active] 1089446000719 putative CoA binding site [chemical binding]; other site 1089446000720 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 1089446000721 D-inositol-3-phosphate glycosyltransferase; Region: mycothiol_MshA; TIGR03449 1089446000722 putative ADP-binding pocket [chemical binding]; other site 1089446000723 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1089446000724 catalytic core [active] 1089446000725 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1089446000726 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1089446000727 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1089446000728 dimer interface [polypeptide binding]; other site 1089446000729 phosphorylation site [posttranslational modification] 1089446000730 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1089446000731 ATP binding site [chemical binding]; other site 1089446000732 Mg2+ binding site [ion binding]; other site 1089446000733 G-X-G motif; other site 1089446000734 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1089446000735 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1089446000736 active site 1089446000737 phosphorylation site [posttranslational modification] 1089446000738 intermolecular recognition site; other site 1089446000739 dimerization interface [polypeptide binding]; other site 1089446000740 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1089446000741 DNA binding site [nucleotide binding] 1089446000742 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 1089446000743 Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248 1089446000744 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 1089446000745 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 1089446000746 DNA binding domain, excisionase family; Region: excise; TIGR01764 1089446000747 Thioredoxin; Region: Thioredoxin_4; cl17273 1089446000748 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 1089446000749 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 1089446000750 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 1089446000751 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 1089446000752 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1089446000753 motif II; other site 1089446000754 Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768 1089446000755 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 1089446000756 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 1089446000757 tRNA; other site 1089446000758 putative tRNA binding site [nucleotide binding]; other site 1089446000759 putative NADP binding site [chemical binding]; other site 1089446000760 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 1089446000761 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 1089446000762 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708 1089446000763 domain interfaces; other site 1089446000764 active site 1089446000765 S-AdoMet dependent tetrapyrrole methylases; Region: TP_methylase; cd09815 1089446000766 active site 1089446000767 homodimer interface [polypeptide binding]; other site 1089446000768 SAM binding site [chemical binding]; other site 1089446000769 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 1089446000770 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 1089446000771 active site 1089446000772 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 1089446000773 dimer interface [polypeptide binding]; other site 1089446000774 active site 1089446000775 Schiff base residues; other site 1089446000776 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1089446000777 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 1089446000778 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 1089446000779 substrate binding site [chemical binding]; other site 1089446000780 active site 1089446000781 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 1089446000782 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 1089446000783 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1089446000784 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 1089446000785 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1089446000786 inhibitor-cofactor binding pocket; inhibition site 1089446000787 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1089446000788 catalytic residue [active] 1089446000789 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1089446000790 catalytic core [active] 1089446000791 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 1089446000792 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1089446000793 catalytic residues [active] 1089446000794 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 1089446000795 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; pfam02683 1089446000796 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; COG1333 1089446000797 ResB-like family; Region: ResB; pfam05140 1089446000798 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1089446000799 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1089446000800 S-adenosylmethionine binding site [chemical binding]; other site 1089446000801 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1089446000802 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1089446000803 Walker A/P-loop; other site 1089446000804 ATP binding site [chemical binding]; other site 1089446000805 Q-loop/lid; other site 1089446000806 ABC transporter signature motif; other site 1089446000807 Walker B; other site 1089446000808 D-loop; other site 1089446000809 H-loop/switch region; other site 1089446000810 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 1089446000811 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1089446000812 intersubunit interface [polypeptide binding]; other site 1089446000813 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 1089446000814 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1089446000815 ABC-ATPase subunit interface; other site 1089446000816 dimer interface [polypeptide binding]; other site 1089446000817 putative PBP binding regions; other site 1089446000818 cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144 1089446000819 Protein of unknown function (DUF4229); Region: DUF4229; pfam14012 1089446000820 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 1089446000821 UbiA prenyltransferase family; Region: UbiA; pfam01040 1089446000822 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK07824 1089446000823 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1089446000824 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1089446000825 acyl-activating enzyme (AAE) consensus motif; other site 1089446000826 acyl-activating enzyme (AAE) consensus motif; other site 1089446000827 AMP binding site [chemical binding]; other site 1089446000828 active site 1089446000829 CoA binding site [chemical binding]; other site 1089446000830 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 1089446000831 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1089446000832 substrate binding site [chemical binding]; other site 1089446000833 oxyanion hole (OAH) forming residues; other site 1089446000834 trimer interface [polypeptide binding]; other site 1089446000835 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 1089446000836 C4-dicarboxylate transporter [Energy production and conversion]; Region: DcuC; cl17322 1089446000837 O-succinylbenzoate synthase; Provisional; Region: PRK02901 1089446000838 o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320 1089446000839 active site 1089446000840 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 1089446000841 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 1089446000842 dimer interface [polypeptide binding]; other site 1089446000843 tetramer interface [polypeptide binding]; other site 1089446000844 PYR/PP interface [polypeptide binding]; other site 1089446000845 TPP binding site [chemical binding]; other site 1089446000846 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 1089446000847 TPP-binding site; other site 1089446000848 Protein of unknown function (DUF3592); Region: DUF3592; pfam12158 1089446000849 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 1089446000850 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1089446000851 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 1089446000852 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1089446000853 S-adenosylmethionine binding site [chemical binding]; other site 1089446000854 NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl17195 1089446000855 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 1089446000856 NAD(P) binding site [chemical binding]; other site 1089446000857 LDH/MDH dimer interface [polypeptide binding]; other site 1089446000858 substrate binding site [chemical binding]; other site 1089446000859 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 1089446000860 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1089446000861 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1089446000862 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1089446000863 substrate binding pocket [chemical binding]; other site 1089446000864 chain length determination region; other site 1089446000865 substrate-Mg2+ binding site; other site 1089446000866 catalytic residues [active] 1089446000867 aspartate-rich region 1; other site 1089446000868 active site lid residues [active] 1089446000869 aspartate-rich region 2; other site 1089446000870 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 1089446000871 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 1089446000872 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 1089446000873 putative homodimer interface [polypeptide binding]; other site 1089446000874 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 1089446000875 heterodimer interface [polypeptide binding]; other site 1089446000876 homodimer interface [polypeptide binding]; other site 1089446000877 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 1089446000878 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 1089446000879 23S rRNA interface [nucleotide binding]; other site 1089446000880 L7/L12 interface [polypeptide binding]; other site 1089446000881 putative thiostrepton binding site; other site 1089446000882 L25 interface [polypeptide binding]; other site 1089446000883 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 1089446000884 mRNA/rRNA interface [nucleotide binding]; other site 1089446000885 Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585 1089446000886 trimer interface [polypeptide binding]; other site 1089446000887 active site 1089446000888 G bulge; other site 1089446000889 Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585 1089446000890 trimer interface [polypeptide binding]; other site 1089446000891 active site 1089446000892 G bulge; other site 1089446000893 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1089446000894 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 1089446000895 FMN binding site [chemical binding]; other site 1089446000896 active site 1089446000897 substrate binding site [chemical binding]; other site 1089446000898 catalytic residue [active] 1089446000899 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 1089446000900 23S rRNA interface [nucleotide binding]; other site 1089446000901 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 1089446000902 50S ribosomal protein L7/L12; Reviewed; Region: rplL; PRK00157 1089446000903 L11 interface [polypeptide binding]; other site 1089446000904 putative EF-Tu interaction site [polypeptide binding]; other site 1089446000905 putative EF-G interaction site [polypeptide binding]; other site 1089446000906 actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769 1089446000907 anchored repeat ABC transporter, substrate-binding protein; Region: anch_rpt_subst; TIGR03772 1089446000908 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1089446000909 actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769 1089446000910 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1089446000911 actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769 1089446000912 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 1089446000913 anchored repeat-type ABC transporter, ATP-binding subunit; Region: anch_rpt_ABC; TIGR03771 1089446000914 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 1089446000915 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1089446000916 ABC-ATPase subunit interface; other site 1089446000917 dimer interface [polypeptide binding]; other site 1089446000918 putative PBP binding regions; other site 1089446000919 Ethylene insensitive 3; Region: EIN3; cl04813 1089446000920 Protein of unknown function (DUF3068); Region: DUF3068; pfam11271 1089446000921 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 1089446000922 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 1089446000923 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 1089446000924 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 1089446000925 RPB1 interaction site [polypeptide binding]; other site 1089446000926 RPB10 interaction site [polypeptide binding]; other site 1089446000927 RPB11 interaction site [polypeptide binding]; other site 1089446000928 RPB3 interaction site [polypeptide binding]; other site 1089446000929 RPB12 interaction site [polypeptide binding]; other site 1089446000930 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 1089446000931 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 1089446000932 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 1089446000933 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 1089446000934 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 1089446000935 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 1089446000936 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 1089446000937 G-loop; other site 1089446000938 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 1089446000939 DNA binding site [nucleotide binding] 1089446000940 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 1089446000941 Histidine kinase; Region: HisKA_3; pfam07730 1089446000942 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 1089446000943 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1089446000944 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1089446000945 active site 1089446000946 phosphorylation site [posttranslational modification] 1089446000947 intermolecular recognition site; other site 1089446000948 dimerization interface [polypeptide binding]; other site 1089446000949 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1089446000950 DNA binding residues [nucleotide binding] 1089446000951 dimerization interface [polypeptide binding]; other site 1089446000952 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1089446000953 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 1089446000954 Walker A/P-loop; other site 1089446000955 ATP binding site [chemical binding]; other site 1089446000956 Q-loop/lid; other site 1089446000957 ABC transporter signature motif; other site 1089446000958 Walker B; other site 1089446000959 D-loop; other site 1089446000960 H-loop/switch region; other site 1089446000961 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 1089446000962 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 1089446000963 TIGR03943 family protein; Region: TIGR03943 1089446000964 Predicted permease; Region: DUF318; cl17795 1089446000965 anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG2; TIGR02495 1089446000966 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1089446000967 FeS/SAM binding site; other site 1089446000968 Anaerobic ribonucleoside-triphosphate reductase; Region: NRDD; pfam13597 1089446000969 Class III ribonucleotide reductase; Region: RNR_III; cd01675 1089446000970 effector binding site; other site 1089446000971 active site 1089446000972 Zn binding site [ion binding]; other site 1089446000973 glycine loop; other site 1089446000974 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 1089446000975 S17 interaction site [polypeptide binding]; other site 1089446000976 S8 interaction site; other site 1089446000977 16S rRNA interaction site [nucleotide binding]; other site 1089446000978 streptomycin interaction site [chemical binding]; other site 1089446000979 23S rRNA interaction site [nucleotide binding]; other site 1089446000980 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 1089446000981 30S ribosomal protein S7; Validated; Region: PRK05302 1089446000982 elongation factor G; Reviewed; Region: PRK00007 1089446000983 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 1089446000984 G1 box; other site 1089446000985 putative GEF interaction site [polypeptide binding]; other site 1089446000986 GTP/Mg2+ binding site [chemical binding]; other site 1089446000987 Switch I region; other site 1089446000988 G2 box; other site 1089446000989 G3 box; other site 1089446000990 Switch II region; other site 1089446000991 G4 box; other site 1089446000992 G5 box; other site 1089446000993 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 1089446000994 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 1089446000995 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 1089446000996 elongation factor Tu; Reviewed; Region: PRK00049 1089446000997 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 1089446000998 G1 box; other site 1089446000999 GEF interaction site [polypeptide binding]; other site 1089446001000 GTP/Mg2+ binding site [chemical binding]; other site 1089446001001 Switch I region; other site 1089446001002 G2 box; other site 1089446001003 G3 box; other site 1089446001004 Switch II region; other site 1089446001005 G4 box; other site 1089446001006 G5 box; other site 1089446001007 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 1089446001008 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 1089446001009 Antibiotic Binding Site [chemical binding]; other site 1089446001010 Asp23 family; Region: Asp23; cl00574 1089446001011 Asp23 family; Region: Asp23; cl00574 1089446001012 Asp23 family; Region: Asp23; pfam03780 1089446001013 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 1089446001014 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 1089446001015 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 1089446001016 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 1089446001017 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 1089446001018 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 1089446001019 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 1089446001020 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 1089446001021 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 1089446001022 putative translocon binding site; other site 1089446001023 protein-rRNA interface [nucleotide binding]; other site 1089446001024 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 1089446001025 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 1089446001026 G-X-X-G motif; other site 1089446001027 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 1089446001028 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 1089446001029 23S rRNA interface [nucleotide binding]; other site 1089446001030 5S rRNA interface [nucleotide binding]; other site 1089446001031 putative antibiotic binding site [chemical binding]; other site 1089446001032 L25 interface [polypeptide binding]; other site 1089446001033 L27 interface [polypeptide binding]; other site 1089446001034 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 1089446001035 putative translocon interaction site; other site 1089446001036 23S rRNA interface [nucleotide binding]; other site 1089446001037 signal recognition particle (SRP54) interaction site; other site 1089446001038 L23 interface [polypeptide binding]; other site 1089446001039 trigger factor interaction site; other site 1089446001040 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 1089446001041 The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501 1089446001042 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 1089446001043 glutathione transporter ATP-binding protein; Provisional; Region: PRK10261 1089446001044 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1089446001045 Walker A/P-loop; other site 1089446001046 ATP binding site [chemical binding]; other site 1089446001047 Q-loop/lid; other site 1089446001048 ABC transporter signature motif; other site 1089446001049 Walker B; other site 1089446001050 D-loop; other site 1089446001051 H-loop/switch region; other site 1089446001052 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1089446001053 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1089446001054 Walker A/P-loop; other site 1089446001055 ATP binding site [chemical binding]; other site 1089446001056 Q-loop/lid; other site 1089446001057 ABC transporter signature motif; other site 1089446001058 Walker B; other site 1089446001059 D-loop; other site 1089446001060 H-loop/switch region; other site 1089446001061 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1089446001062 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 1089446001063 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1089446001064 dimer interface [polypeptide binding]; other site 1089446001065 conserved gate region; other site 1089446001066 putative PBP binding loops; other site 1089446001067 ABC-ATPase subunit interface; other site 1089446001068 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1089446001069 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1089446001070 putative PBP binding loops; other site 1089446001071 dimer interface [polypeptide binding]; other site 1089446001072 ABC-ATPase subunit interface; other site 1089446001073 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 1089446001074 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 1089446001075 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 1089446001076 RNA binding site [nucleotide binding]; other site 1089446001077 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 1089446001078 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 1089446001079 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 1089446001080 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 1089446001081 serine transporter; Region: stp; TIGR00814 1089446001082 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 1089446001083 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 1089446001084 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 1089446001085 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 1089446001086 active site 1089446001087 homotetramer interface [polypeptide binding]; other site 1089446001088 homodimer interface [polypeptide binding]; other site 1089446001089 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 1089446001090 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1089446001091 active site 1089446001092 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 1089446001093 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 1089446001094 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1089446001095 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1089446001096 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 1089446001097 5S rRNA interface [nucleotide binding]; other site 1089446001098 23S rRNA interface [nucleotide binding]; other site 1089446001099 L5 interface [polypeptide binding]; other site 1089446001100 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 1089446001101 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 1089446001102 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 1089446001103 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 1089446001104 23S rRNA binding site [nucleotide binding]; other site 1089446001105 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 1089446001106 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 1089446001107 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1089446001108 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1089446001109 dimer interface [polypeptide binding]; other site 1089446001110 conserved gate region; other site 1089446001111 putative PBP binding loops; other site 1089446001112 ABC-ATPase subunit interface; other site 1089446001113 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1089446001114 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1089446001115 dimer interface [polypeptide binding]; other site 1089446001116 conserved gate region; other site 1089446001117 putative PBP binding loops; other site 1089446001118 ABC-ATPase subunit interface; other site 1089446001119 Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226 1089446001120 Domain of unknown function (DUF4032); Region: DUF4032; pfam13224 1089446001121 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 1089446001122 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1089446001123 Walker A/P-loop; other site 1089446001124 ATP binding site [chemical binding]; other site 1089446001125 Q-loop/lid; other site 1089446001126 ABC transporter signature motif; other site 1089446001127 Walker B; other site 1089446001128 D-loop; other site 1089446001129 H-loop/switch region; other site 1089446001130 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 1089446001131 SecY translocase; Region: SecY; pfam00344 1089446001132 adenylate kinase; Reviewed; Region: adk; PRK00279 1089446001133 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 1089446001134 AMP-binding site [chemical binding]; other site 1089446001135 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 1089446001136 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 1089446001137 active site 1089446001138 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260 1089446001139 catalytic site [active] 1089446001140 BNR repeat-like domain; Region: BNR_2; pfam13088 1089446001141 Asp-box motif; other site 1089446001142 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1089446001143 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 1089446001144 rRNA binding site [nucleotide binding]; other site 1089446001145 predicted 30S ribosome binding site; other site 1089446001146 Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099 1089446001147 30S ribosomal protein S13; Region: bact_S13; TIGR03631 1089446001148 30S ribosomal protein S11; Validated; Region: PRK05309 1089446001149 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 1089446001150 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 1089446001151 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1089446001152 RNA binding surface [nucleotide binding]; other site 1089446001153 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 1089446001154 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 1089446001155 alphaNTD - beta interaction site [polypeptide binding]; other site 1089446001156 alphaNTD homodimer interface [polypeptide binding]; other site 1089446001157 alphaNTD - beta' interaction site [polypeptide binding]; other site 1089446001158 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 1089446001159 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 1089446001160 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 1089446001161 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 1089446001162 dimerization interface 3.5A [polypeptide binding]; other site 1089446001163 active site 1089446001164 Protein of unknown function (DUF690); Region: DUF690; cl04939 1089446001165 Putative transmembrane protein (PGPGW); Region: PGPGW; cl09870 1089446001166 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 1089446001167 active site 1089446001168 catalytic residues [active] 1089446001169 WXG100 protein secretion system (Wss), protein YukD; Region: YukD; cl17489 1089446001170 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 1089446001171 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1089446001172 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 1089446001173 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1089446001174 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1089446001175 Walker A/P-loop; other site 1089446001176 ATP binding site [chemical binding]; other site 1089446001177 type VII secretion-associated protein, Rv3446c family, C-terminal domain; Region: T7SS_Rv3446c; TIGR03931 1089446001178 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 1089446001179 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 1089446001180 23S rRNA interface [nucleotide binding]; other site 1089446001181 L3 interface [polypeptide binding]; other site 1089446001182 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 1089446001183 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14318 1089446001184 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 1089446001185 active site 1089446001186 substrate binding site [chemical binding]; other site 1089446001187 metal binding site [ion binding]; metal-binding site 1089446001188 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1089446001189 alanine racemase; Reviewed; Region: alr; PRK00053 1089446001190 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 1089446001191 active site 1089446001192 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1089446001193 dimer interface [polypeptide binding]; other site 1089446001194 substrate binding site [chemical binding]; other site 1089446001195 catalytic residues [active] 1089446001196 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 1089446001197 Predicted permease [General function prediction only]; Region: COG2985 1089446001198 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 1089446001199 TrkA-C domain; Region: TrkA_C; pfam02080 1089446001200 AspT/YidE/YbjL antiporter duplication domain; Region: YidE_YbjL_dupl; TIGR01625 1089446001201 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 1089446001202 Glycoprotease family; Region: Peptidase_M22; pfam00814 1089446001203 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 1089446001204 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1089446001205 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1089446001206 Coenzyme A binding pocket [chemical binding]; other site 1089446001207 UGMP family protein; Validated; Region: PRK09604 1089446001208 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 1089446001209 oligomerisation interface [polypeptide binding]; other site 1089446001210 mobile loop; other site 1089446001211 roof hairpin; other site 1089446001212 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 1089446001213 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 1089446001214 ring oligomerisation interface [polypeptide binding]; other site 1089446001215 ATP/Mg binding site [chemical binding]; other site 1089446001216 stacking interactions; other site 1089446001217 hinge regions; other site 1089446001218 RNA polymerase sigma factor SigD; Reviewed; Region: PRK09648 1089446001219 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1089446001220 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1089446001221 DNA binding residues [nucleotide binding] 1089446001222 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 1089446001223 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1089446001224 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 1089446001225 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 1089446001226 active site 1089446001227 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK08649 1089446001228 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1089446001229 phosphate binding site [ion binding]; other site 1089446001230 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 1089446001231 GMP synthase; Reviewed; Region: guaA; PRK00074 1089446001232 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 1089446001233 AMP/PPi binding site [chemical binding]; other site 1089446001234 candidate oxyanion hole; other site 1089446001235 catalytic triad [active] 1089446001236 potential glutamine specificity residues [chemical binding]; other site 1089446001237 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 1089446001238 ATP Binding subdomain [chemical binding]; other site 1089446001239 Ligand Binding sites [chemical binding]; other site 1089446001240 Dimerization subdomain; other site 1089446001241 PspC domain; Region: PspC; cl00864 1089446001242 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 1089446001243 PspC domain; Region: PspC; pfam04024 1089446001244 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1089446001245 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 1089446001246 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1089446001247 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1089446001248 active site 1089446001249 phosphorylation site [posttranslational modification] 1089446001250 intermolecular recognition site; other site 1089446001251 dimerization interface [polypeptide binding]; other site 1089446001252 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1089446001253 dimerization interface [polypeptide binding]; other site 1089446001254 DNA binding residues [nucleotide binding] 1089446001255 TRX-like [2Fe-2S] Ferredoxin (Fd) family, Sucrase subfamily; composed of proteins with similarity to a novel plant enzyme, isolated from potato, which contains a Fd-like domain and exhibits sucrolytic activity. The putative active site of the Fd-like...; Region: TRX_Fd_Sucrase; cd03062 1089446001256 putative dimer interface [polypeptide binding]; other site 1089446001257 putative [2Fe-2S] cluster binding site [ion binding]; other site 1089446001258 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1089446001259 dimer interface [polypeptide binding]; other site 1089446001260 conserved gate region; other site 1089446001261 ABC-ATPase subunit interface; other site 1089446001262 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 1089446001263 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 1089446001264 Walker A/P-loop; other site 1089446001265 ATP binding site [chemical binding]; other site 1089446001266 Q-loop/lid; other site 1089446001267 ABC transporter signature motif; other site 1089446001268 Walker B; other site 1089446001269 D-loop; other site 1089446001270 H-loop/switch region; other site 1089446001271 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 1089446001272 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 1089446001273 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 1089446001274 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1089446001275 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 1089446001276 intersubunit interface [polypeptide binding]; other site 1089446001277 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 1089446001278 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 1089446001279 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1089446001280 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1089446001281 ABC-ATPase subunit interface; other site 1089446001282 dimer interface [polypeptide binding]; other site 1089446001283 putative PBP binding regions; other site 1089446001284 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1089446001285 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 1089446001286 ABC-ATPase subunit interface; other site 1089446001287 dimer interface [polypeptide binding]; other site 1089446001288 putative PBP binding regions; other site 1089446001289 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 1089446001290 Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529 1089446001291 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 1089446001292 This entry represents the core domain of the ferrous iron (Fe2+) transport protein FeoA found in bacteria; Region: FeoA; smart00899 1089446001293 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 1089446001294 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14193 1089446001295 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 1089446001296 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 1089446001297 homodimer interface [polypeptide binding]; other site 1089446001298 NADP binding site [chemical binding]; other site 1089446001299 substrate binding site [chemical binding]; other site 1089446001300 Protein of unknown function (DUF3017); Region: DUF3017; pfam11222 1089446001301 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1089446001302 active site 1089446001303 Htaa; Region: HtaA; pfam04213 1089446001304 Htaa; Region: HtaA; pfam04213 1089446001305 ABC-type hemin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ChuT; COG4558 1089446001306 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1089446001307 intersubunit interface [polypeptide binding]; other site 1089446001308 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1089446001309 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1089446001310 ABC-ATPase subunit interface; other site 1089446001311 dimer interface [polypeptide binding]; other site 1089446001312 putative PBP binding regions; other site 1089446001313 hemin importer ATP-binding subunit; Provisional; Region: hmuV; PRK13548 1089446001314 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1089446001315 Walker A/P-loop; other site 1089446001316 ATP binding site [chemical binding]; other site 1089446001317 Q-loop/lid; other site 1089446001318 ABC transporter signature motif; other site 1089446001319 Walker B; other site 1089446001320 D-loop; other site 1089446001321 H-loop/switch region; other site 1089446001322 Htaa; Region: HtaA; pfam04213 1089446001323 O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK05613 1089446001324 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1089446001325 homodimer interface [polypeptide binding]; other site 1089446001326 substrate-cofactor binding pocket; other site 1089446001327 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1089446001328 catalytic residue [active] 1089446001329 Monomeric isocitrate dehydrogenase [Energy production and conversion]; Region: Icd; COG2838 1089446001330 Monomeric isocitrate dehydrogenase; Region: IDH; cl15383 1089446001331 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1089446001332 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1089446001333 putative substrate translocation pore; other site 1089446001334 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 1089446001335 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1089446001336 DNA binding residues [nucleotide binding] 1089446001337 dimer interface [polypeptide binding]; other site 1089446001338 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 1089446001339 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 1089446001340 putative catalytic site [active] 1089446001341 putative metal binding site [ion binding]; other site 1089446001342 putative phosphate binding site [ion binding]; other site 1089446001343 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 1089446001344 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 1089446001345 active site 1089446001346 HIGH motif; other site 1089446001347 dimer interface [polypeptide binding]; other site 1089446001348 KMSKS motif; other site 1089446001349 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 1089446001350 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 1089446001351 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1089446001352 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1089446001353 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1089446001354 active site 1089446001355 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1089446001356 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1089446001357 non-specific DNA binding site [nucleotide binding]; other site 1089446001358 salt bridge; other site 1089446001359 sequence-specific DNA binding site [nucleotide binding]; other site 1089446001360 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 1089446001361 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 1089446001362 active site 1089446001363 substrate binding site [chemical binding]; other site 1089446001364 metal binding site [ion binding]; metal-binding site 1089446001365 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1089446001366 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like4; cd08014 1089446001367 metal binding site [ion binding]; metal-binding site 1089446001368 putative dimer interface [polypeptide binding]; other site 1089446001369 flavoprotein disulfide reductase; Reviewed; Region: PRK07845 1089446001370 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1089446001371 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1089446001372 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1089446001373 pyruvate carboxylase; Reviewed; Region: PRK12999 1089446001374 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1089446001375 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1089446001376 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1089446001377 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 1089446001378 active site 1089446001379 catalytic residues [active] 1089446001380 metal binding site [ion binding]; metal-binding site 1089446001381 homodimer binding site [polypeptide binding]; other site 1089446001382 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1089446001383 carboxyltransferase (CT) interaction site; other site 1089446001384 biotinylation site [posttranslational modification]; other site 1089446001385 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1089446001386 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1089446001387 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1089446001388 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 1089446001389 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1089446001390 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1089446001391 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1089446001392 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1089446001393 carboxyltransferase (CT) interaction site; other site 1089446001394 biotinylation site [posttranslational modification]; other site 1089446001395 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 1089446001396 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 1089446001397 active site residue [active] 1089446001398 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 1089446001399 active site residue [active] 1089446001400 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1089446001401 Protein of unknown function (DUF3151); Region: DUF3151; pfam11349 1089446001402 Maf-like protein; Region: Maf; pfam02545 1089446001403 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 1089446001404 active site 1089446001405 dimer interface [polypeptide binding]; other site 1089446001406 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 1089446001407 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1089446001408 substrate binding site [chemical binding]; other site 1089446001409 dimer interface [polypeptide binding]; other site 1089446001410 ATP binding site [chemical binding]; other site 1089446001411 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1089446001412 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1089446001413 DNA binding site [nucleotide binding] 1089446001414 domain linker motif; other site 1089446001415 Ligand-binding domain of DNA-binding regulatory protein from Corynebacterium glutamicum which has a unique ability to produce significant amounts of L-glutamate directly from cheap sugar and ammonia; Region: PBP1_LacI_like_13; cd06299 1089446001416 putative ligand binding site [chemical binding]; other site 1089446001417 dimerization interface [polypeptide binding]; other site 1089446001418 Acyl-CoA carboxylase epsilon subunit; Region: ACC_epsilon; pfam13822 1089446001419 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 1089446001420 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1089446001421 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1089446001422 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 1089446001423 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1089446001424 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1089446001425 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 1089446001426 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 1089446001427 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 1089446001428 ATP-grasp domain; Region: ATP-grasp; pfam02222 1089446001429 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 1089446001430 Uncharacterized conserved protein [Function unknown]; Region: COG1434 1089446001431 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 1089446001432 putative active site [active] 1089446001433 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1089446001434 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1089446001435 dimer interface [polypeptide binding]; other site 1089446001436 conserved gate region; other site 1089446001437 putative PBP binding loops; other site 1089446001438 ABC-ATPase subunit interface; other site 1089446001439 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1089446001440 dimer interface [polypeptide binding]; other site 1089446001441 conserved gate region; other site 1089446001442 putative PBP binding loops; other site 1089446001443 ABC-ATPase subunit interface; other site 1089446001444 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1089446001445 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1089446001446 TIGR03089 family protein; Region: TIGR03089 1089446001447 Transcriptional regulator [Transcription]; Region: LytR; COG1316 1089446001448 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 1089446001449 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 1089446001450 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 1089446001451 Probable Catalytic site; other site 1089446001452 metal-binding site 1089446001453 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 1089446001454 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 1089446001455 active site 1089446001456 Substrate binding site; other site 1089446001457 Mg++ binding site; other site 1089446001458 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1089446001459 putative trimer interface [polypeptide binding]; other site 1089446001460 putative CoA binding site [chemical binding]; other site 1089446001461 Transcription factor WhiB; Region: Whib; pfam02467 1089446001462 Minimal MMP-like domain found in a group of hypothetical proteins from alphaproteobacteria and actinobacteria; Region: MMP_TTHA0227_like_1; cd12954 1089446001463 Protein of unknown function (DUF3499); Region: DUF3499; pfam12005 1089446001464 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 1089446001465 phosphomannomutase/phosphoglucomutase; Reviewed; Region: manB; PRK09542 1089446001466 active site 1089446001467 substrate binding site [chemical binding]; other site 1089446001468 metal binding site [ion binding]; metal-binding site 1089446001469 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 1089446001470 mannose-6-phosphate isomerase; Provisional; Region: PRK15131 1089446001471 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 1089446001472 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 1089446001473 Domain of unknown function (DUF4259); Region: DUF4259; pfam14078 1089446001474 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 1089446001475 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 1089446001476 homotetramer interface [polypeptide binding]; other site 1089446001477 ligand binding site [chemical binding]; other site 1089446001478 catalytic site [active] 1089446001479 NAD binding site [chemical binding]; other site 1089446001480 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 1089446001481 Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125 1089446001482 TMP-binding site; other site 1089446001483 ATP-binding site [chemical binding]; other site 1089446001484 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1089446001485 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1089446001486 active site 1089446001487 phosphorylation site [posttranslational modification] 1089446001488 intermolecular recognition site; other site 1089446001489 dimerization interface [polypeptide binding]; other site 1089446001490 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1089446001491 DNA binding site [nucleotide binding] 1089446001492 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1089446001493 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1089446001494 dimerization interface [polypeptide binding]; other site 1089446001495 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1089446001496 dimer interface [polypeptide binding]; other site 1089446001497 phosphorylation site [posttranslational modification] 1089446001498 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1089446001499 ATP binding site [chemical binding]; other site 1089446001500 Mg2+ binding site [ion binding]; other site 1089446001501 G-X-G motif; other site 1089446001502 lipoprotein LpqB; Provisional; Region: PRK13616 1089446001503 Sporulation and spore germination; Region: Germane; pfam10646 1089446001504 comF family protein; Region: comF; TIGR00201 1089446001505 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1089446001506 active site 1089446001507 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 1089446001508 30S subunit binding site; other site 1089446001509 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 1089446001510 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1089446001511 ATP binding site [chemical binding]; other site 1089446001512 putative Mg++ binding site [ion binding]; other site 1089446001513 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 1089446001514 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 1089446001515 nucleotide binding region [chemical binding]; other site 1089446001516 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 1089446001517 REG-2-like, HAD superfamily (subfamily IA) hydrolase; Region: DREG-2; TIGR02252 1089446001518 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_2; cd06216 1089446001519 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 1089446001520 FAD binding pocket [chemical binding]; other site 1089446001521 FAD binding motif [chemical binding]; other site 1089446001522 phosphate binding motif [ion binding]; other site 1089446001523 beta-alpha-beta structure motif; other site 1089446001524 NAD binding pocket [chemical binding]; other site 1089446001525 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 1089446001526 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1089446001527 catalytic loop [active] 1089446001528 iron binding site [ion binding]; other site 1089446001529 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 1089446001530 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 1089446001531 putative di-iron ligands [ion binding]; other site 1089446001532 Predicted GTPases [General function prediction only]; Region: COG1162 1089446001533 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 1089446001534 GTPase/Zn-binding domain interface [polypeptide binding]; other site 1089446001535 GTP/Mg2+ binding site [chemical binding]; other site 1089446001536 G4 box; other site 1089446001537 G5 box; other site 1089446001538 G1 box; other site 1089446001539 Switch I region; other site 1089446001540 G2 box; other site 1089446001541 G3 box; other site 1089446001542 Switch II region; other site 1089446001543 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 1089446001544 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 1089446001545 hinge; other site 1089446001546 active site 1089446001547 Uncharacterized conserved protein [Function unknown]; Region: COG2135 1089446001548 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 1089446001549 putative deacylase active site [active] 1089446001550 RNA polymerase sigma-70 factor, TIGR02947 family; Region: SigH_actino 1089446001551 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1089446001552 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1089446001553 DNA binding residues [nucleotide binding] 1089446001554 mycothiol system anti-sigma-R factor; Region: antisig_RsrA; cl15806 1089446001555 Transcription factor WhiB; Region: Whib; pfam02467 1089446001556 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 1089446001557 active site 1089446001558 catalytic triad [active] 1089446001559 oxyanion hole [active] 1089446001560 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 1089446001561 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1089446001562 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1089446001563 ATP binding site [chemical binding]; other site 1089446001564 Mg++ binding site [ion binding]; other site 1089446001565 motif III; other site 1089446001566 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1089446001567 nucleotide binding region [chemical binding]; other site 1089446001568 Protein of unknown function (DUF3107); Region: DUF3107; pfam11305 1089446001569 Protein of unknown function (DUF3152); Region: DUF3152; pfam11350 1089446001570 TIGR02569 family protein; Region: TIGR02569_actnb 1089446001571 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 1089446001572 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 1089446001573 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 1089446001574 Part of AAA domain; Region: AAA_19; pfam13245 1089446001575 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 1089446001576 Ion channel; Region: Ion_trans_2; pfam07885 1089446001577 Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226 1089446001578 TrkA-N domain; Region: TrkA_N; pfam02254 1089446001579 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 1089446001580 putative NADH binding site [chemical binding]; other site 1089446001581 putative active site [active] 1089446001582 nudix motif; other site 1089446001583 putative metal binding site [ion binding]; other site 1089446001584 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 1089446001585 Part of AAA domain; Region: AAA_19; pfam13245 1089446001586 Family description; Region: UvrD_C_2; pfam13538 1089446001587 HRDC domain; Region: HRDC; pfam00570 1089446001588 Protein of unknown function DUF45; Region: DUF45; cl00636 1089446001589 putative hydrolase; Region: TIGR03624 1089446001590 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 1089446001591 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1089446001592 hypothetical protein; Validated; Region: PRK00068 1089446001593 Uncharacterized conserved protein [Function unknown]; Region: COG1615; cl09133 1089446001594 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 1089446001595 sequence-specific DNA binding site [nucleotide binding]; other site 1089446001596 salt bridge; other site 1089446001597 Abi-like protein; Region: Abi_2; pfam07751 1089446001598 Predicted helicase [General function prediction only]; Region: COG4889 1089446001599 Restriction endonuclease; Region: Mrr_cat_2; pfam13156 1089446001600 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1089446001601 ATP binding site [chemical binding]; other site 1089446001602 putative Mg++ binding site [ion binding]; other site 1089446001603 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1089446001604 ATP-binding site [chemical binding]; other site 1089446001605 Methyltransferase domain; Region: Methyltransf_26; pfam13659 1089446001606 Uncharacterized conserved protein (DUF2249); Region: DUF2249; pfam10006 1089446001607 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 1089446001608 nitrite reductase, copper-containing; Region: Cu_nitrite_red; TIGR02376 1089446001609 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 1089446001610 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 1089446001611 Predicted membrane protein [Function unknown]; Region: COG2311 1089446001612 Protein of unknown function (DUF1624); Region: DUF1624; cl01394 1089446001613 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1089446001614 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1089446001615 acyl-activating enzyme (AAE) consensus motif; other site 1089446001616 AMP binding site [chemical binding]; other site 1089446001617 active site 1089446001618 CoA binding site [chemical binding]; other site 1089446001619 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1089446001620 non-ribosomal peptide synthetase terminal domain of unknown function; Region: NRPS_term_dom; TIGR02353 1089446001621 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1089446001622 putative trimer interface [polypeptide binding]; other site 1089446001623 putative CoA binding site [chemical binding]; other site 1089446001624 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1089446001625 putative trimer interface [polypeptide binding]; other site 1089446001626 putative CoA binding site [chemical binding]; other site 1089446001627 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1089446001628 oxaloacetate decarboxylase; Provisional; Region: PRK12330 1089446001629 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 1089446001630 active site 1089446001631 catalytic residues [active] 1089446001632 metal binding site [ion binding]; metal-binding site 1089446001633 homodimer binding site [polypeptide binding]; other site 1089446001634 methylmalonyl-CoA decarboxylase alpha subunit; Region: mmdA; TIGR01117 1089446001635 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1089446001636 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1089446001637 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1089446001638 carboxyltransferase (CT) interaction site; other site 1089446001639 biotinylation site [posttranslational modification]; other site 1089446001640 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1089446001641 Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate, or similar substrates; Region: Bacterial_IMPase_like_1; cd01641 1089446001642 active site 1089446001643 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 1089446001644 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1089446001645 active site 1089446001646 peptide chain release factor 2; Validated; Region: prfB; PRK00578 1089446001647 This domain is found in peptide chain release factors; Region: PCRF; smart00937 1089446001648 RF-1 domain; Region: RF-1; pfam00472 1089446001649 topology modulation protein; Provisional; Region: PRK07261 1089446001650 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cd02019 1089446001651 active site 1089446001652 Putative p-aminobenzoyl-glutamate transporter [Coenzyme metabolism]; Region: AbgT; COG2978 1089446001653 p-Aminobenzoyl-glutamate transporter family; Region: ydaH; TIGR00819 1089446001654 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 1089446001655 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1089446001656 Walker A/P-loop; other site 1089446001657 ATP binding site [chemical binding]; other site 1089446001658 Q-loop/lid; other site 1089446001659 ABC transporter signature motif; other site 1089446001660 Walker B; other site 1089446001661 D-loop; other site 1089446001662 H-loop/switch region; other site 1089446001663 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 1089446001664 FtsX-like permease family; Region: FtsX; pfam02687 1089446001665 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 1089446001666 SmpB-tmRNA interface; other site 1089446001667 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA; cl00391 1089446001668 active site clefts [active] 1089446001669 zinc binding site [ion binding]; other site 1089446001670 dimer interface [polypeptide binding]; other site 1089446001671 ABC-type enterochelin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CeuA; COG4607 1089446001672 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1089446001673 intersubunit interface [polypeptide binding]; other site 1089446001674 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1089446001675 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1089446001676 ABC-ATPase subunit interface; other site 1089446001677 dimer interface [polypeptide binding]; other site 1089446001678 putative PBP binding regions; other site 1089446001679 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1089446001680 ABC-ATPase subunit interface; other site 1089446001681 dimer interface [polypeptide binding]; other site 1089446001682 putative PBP binding regions; other site 1089446001683 ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604 1089446001684 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1089446001685 Walker A/P-loop; other site 1089446001686 ATP binding site [chemical binding]; other site 1089446001687 Q-loop/lid; other site 1089446001688 ABC transporter signature motif; other site 1089446001689 Walker B; other site 1089446001690 D-loop; other site 1089446001691 H-loop/switch region; other site 1089446001692 Protein of unknown function (DUF3239); Region: DUF3239; pfam11580 1089446001693 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 1089446001694 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 1089446001695 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1089446001696 ATP binding site [chemical binding]; other site 1089446001697 putative Mg++ binding site [ion binding]; other site 1089446001698 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1089446001699 nucleotide binding region [chemical binding]; other site 1089446001700 ATP-binding site [chemical binding]; other site 1089446001701 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 1089446001702 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 1089446001703 Protein of unknown function (DUF3235); Region: DUF3235; pfam11574 1089446001704 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1089446001705 DNA-binding site [nucleotide binding]; DNA binding site 1089446001706 RNA-binding motif; other site 1089446001707 Protein of unknown function (DUF2771); Region: DUF2771; pfam10969 1089446001708 Glutamine cyclotransferase [Posttranslational modification, protein turnover, chaperones]; Region: COG3823 1089446001709 Protein of unknown function (DUF3027); Region: DUF3027; pfam11228 1089446001710 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 1089446001711 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 1089446001712 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1089446001713 Protein of unknown function (DUF3071); Region: DUF3071; pfam11268 1089446001714 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1089446001715 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1089446001716 catalytic residue [active] 1089446001717 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 1089446001718 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 1089446001719 dimer interface [polypeptide binding]; other site 1089446001720 active site 1089446001721 citrylCoA binding site [chemical binding]; other site 1089446001722 NADH binding [chemical binding]; other site 1089446001723 cationic pore residues; other site 1089446001724 oxalacetate/citrate binding site [chemical binding]; other site 1089446001725 coenzyme A binding site [chemical binding]; other site 1089446001726 catalytic triad [active] 1089446001727 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1089446001728 Carboxyl transferase domain; Region: Carboxyl_trans; pfam01039 1089446001729 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1089446001730 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 1089446001731 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 1089446001732 E-class dimer interface [polypeptide binding]; other site 1089446001733 P-class dimer interface [polypeptide binding]; other site 1089446001734 active site 1089446001735 Cu2+ binding site [ion binding]; other site 1089446001736 Zn2+ binding site [ion binding]; other site 1089446001737 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1089446001738 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1089446001739 active site 1089446001740 catalytic tetrad [active] 1089446001741 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1089446001742 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1089446001743 substrate binding site [chemical binding]; other site 1089446001744 oxyanion hole (OAH) forming residues; other site 1089446001745 trimer interface [polypeptide binding]; other site 1089446001746 Protein of unknown function, DUF485; Region: DUF485; pfam04341 1089446001747 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 1089446001748 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 1089446001749 Na binding site [ion binding]; other site 1089446001750 Domain of unknown function (DUF1906); Region: DUF1906; pfam08924 1089446001751 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 1089446001752 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 1089446001753 Host cell surface-exposed lipoprotein; Region: Lipoprotein_Ltp; pfam07553 1089446001754 Host cell surface-exposed lipoprotein; Region: Lipoprotein_Ltp; pfam07553 1089446001755 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 1089446001756 multidrug efflux protein NorA; Provisional; Region: PRK00187 1089446001757 cation binding site [ion binding]; other site 1089446001758 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1089446001759 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1089446001760 dimer interface [polypeptide binding]; other site 1089446001761 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1089446001762 catalytic residue [active] 1089446001763 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 1089446001764 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1089446001765 catalytic residue [active] 1089446001766 Predicted ornithine cyclodeaminase, mu-crystallin homolog [Amino acid transport and metabolism]; Region: COG2423 1089446001767 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 1089446001768 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 1089446001769 substrate binding pocket [chemical binding]; other site 1089446001770 active site 1089446001771 iron coordination sites [ion binding]; other site 1089446001772 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_17; cd08503 1089446001773 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 1089446001774 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1089446001775 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1089446001776 dimer interface [polypeptide binding]; other site 1089446001777 conserved gate region; other site 1089446001778 putative PBP binding loops; other site 1089446001779 ABC-ATPase subunit interface; other site 1089446001780 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1089446001781 ABC-type uncharacterized transport system, duplicated ATPase component [General function prediction only]; Region: COG4172 1089446001782 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1089446001783 Walker A/P-loop; other site 1089446001784 ATP binding site [chemical binding]; other site 1089446001785 Q-loop/lid; other site 1089446001786 ABC transporter signature motif; other site 1089446001787 Walker B; other site 1089446001788 D-loop; other site 1089446001789 H-loop/switch region; other site 1089446001790 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1089446001791 Walker A/P-loop; other site 1089446001792 ATP binding site [chemical binding]; other site 1089446001793 Q-loop/lid; other site 1089446001794 ABC transporter signature motif; other site 1089446001795 Walker B; other site 1089446001796 D-loop; other site 1089446001797 H-loop/switch region; other site 1089446001798 Precorrin-6A synthase, the cobalamin biosynthesis enzyme CobF; Region: Precorrin-6A-synthase; cd11643 1089446001799 active site 1089446001800 SAM binding site [chemical binding]; other site 1089446001801 homodimer interface [polypeptide binding]; other site 1089446001802 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 1089446001803 catalytic residues [active] 1089446001804 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 1089446001805 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 1089446001806 folate binding site [chemical binding]; other site 1089446001807 NADP+ binding site [chemical binding]; other site 1089446001808 thymidylate synthase; Reviewed; Region: thyA; PRK01827 1089446001809 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 1089446001810 dimerization interface [polypeptide binding]; other site 1089446001811 active site 1089446001812 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 1089446001813 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1089446001814 active site 1089446001815 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1089446001816 putative ATP-dependent helicase Lhr; Provisional; Region: PRK09751 1089446001817 ATP binding site [chemical binding]; other site 1089446001818 putative Mg++ binding site [ion binding]; other site 1089446001819 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1089446001820 nucleotide binding region [chemical binding]; other site 1089446001821 ATP-binding site [chemical binding]; other site 1089446001822 DEAD/H associated; Region: DEAD_assoc; pfam08494 1089446001823 G:T/U mismatch specific DNA glcosylase (MUG); Region: UDG_F2_MUG; cd10028 1089446001824 active site 1089446001825 SUMO-1 interface [polypeptide binding]; other site 1089446001826 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 1089446001827 N-terminal domain of the actinomycetal Nei2 and related DNA glycosylases; Region: AcNei2_N; cd08971 1089446001828 putative DNA binding site [nucleotide binding]; other site 1089446001829 catalytic residue [active] 1089446001830 putative H2TH interface [polypeptide binding]; other site 1089446001831 putative catalytic residues [active] 1089446001832 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1089446001833 hypothetical protein; Provisional; Region: PRK11770 1089446001834 Domain of unknown function (DUF307); Region: DUF307; pfam03733 1089446001835 Domain of unknown function (DUF307); Region: DUF307; pfam03733 1089446001836 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 1089446001837 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 1089446001838 active site 1089446001839 dimer interface [polypeptide binding]; other site 1089446001840 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 1089446001841 dimer interface [polypeptide binding]; other site 1089446001842 active site 1089446001843 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1089446001844 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 1089446001845 tetramerization interface [polypeptide binding]; other site 1089446001846 NAD(P) binding site [chemical binding]; other site 1089446001847 catalytic residues [active] 1089446001848 hypothetical protein; Provisional; Region: PRK07857 1089446001849 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 1089446001850 Part of AAA domain; Region: AAA_19; pfam13245 1089446001851 Family description; Region: UvrD_C_2; pfam13538 1089446001852 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1089446001853 Peptidase family M23; Region: Peptidase_M23; pfam01551 1089446001854 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 1089446001855 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 1089446001856 active site 1089446001857 substrate binding site [chemical binding]; other site 1089446001858 cosubstrate binding site; other site 1089446001859 catalytic site [active] 1089446001860 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 1089446001861 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 1089446001862 purine monophosphate binding site [chemical binding]; other site 1089446001863 dimer interface [polypeptide binding]; other site 1089446001864 putative catalytic residues [active] 1089446001865 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 1089446001866 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1089446001867 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1089446001868 Walker A/P-loop; other site 1089446001869 ATP binding site [chemical binding]; other site 1089446001870 Q-loop/lid; other site 1089446001871 ABC transporter signature motif; other site 1089446001872 Walker B; other site 1089446001873 D-loop; other site 1089446001874 H-loop/switch region; other site 1089446001875 lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096 1089446001876 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1089446001877 substrate binding pocket [chemical binding]; other site 1089446001878 membrane-bound complex binding site; other site 1089446001879 hinge residues; other site 1089446001880 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1089446001881 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1089446001882 dimer interface [polypeptide binding]; other site 1089446001883 conserved gate region; other site 1089446001884 putative PBP binding loops; other site 1089446001885 ABC-ATPase subunit interface; other site 1089446001886 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1089446001887 dimer interface [polypeptide binding]; other site 1089446001888 conserved gate region; other site 1089446001889 putative PBP binding loops; other site 1089446001890 ABC-ATPase subunit interface; other site 1089446001891 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 1089446001892 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1089446001893 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1089446001894 Putative nucleotidyltransferase substrate binding domain; Region: DUF294_C; pfam10335 1089446001895 30S ribosomal protein S18; Provisional; Region: PRK13401 1089446001896 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 1089446001897 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 1089446001898 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 1089446001899 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 1089446001900 50S ribosomal protein L32; Validated; Region: rpmF; PRK01110 1089446001901 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1089446001902 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1089446001903 active site 1089446001904 phosphorylation site [posttranslational modification] 1089446001905 intermolecular recognition site; other site 1089446001906 dimerization interface [polypeptide binding]; other site 1089446001907 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1089446001908 DNA binding site [nucleotide binding] 1089446001909 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1089446001910 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1089446001911 dimerization interface [polypeptide binding]; other site 1089446001912 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1089446001913 dimer interface [polypeptide binding]; other site 1089446001914 phosphorylation site [posttranslational modification] 1089446001915 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1089446001916 ATP binding site [chemical binding]; other site 1089446001917 Mg2+ binding site [ion binding]; other site 1089446001918 G-X-G motif; other site 1089446001919 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 1089446001920 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1089446001921 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1089446001922 protein binding site [polypeptide binding]; other site 1089446001923 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 1089446001924 MPT binding site; other site 1089446001925 trimer interface [polypeptide binding]; other site 1089446001926 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 1089446001927 Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970 1089446001928 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 1089446001929 UDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: GalU; COG1210 1089446001930 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 1089446001931 active site 1089446001932 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 1089446001933 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 1089446001934 dimer interface [polypeptide binding]; other site 1089446001935 putative functional site; other site 1089446001936 putative MPT binding site; other site 1089446001937 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1089446001938 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1089446001939 Coenzyme A binding pocket [chemical binding]; other site 1089446001940 Predicted membrane protein [Function unknown]; Region: COG2259 1089446001941 Predicted integral membrane protein [Function unknown]; Region: COG5660 1089446001942 Putative zinc-finger; Region: zf-HC2; pfam13490 1089446001943 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 1089446001944 BCCT family transporter; Region: BCCT; pfam02028 1089446001945 Uncharacterized membrane protein [Function unknown]; Region: COG3949 1089446001946 Predicted methyltransferases [General function prediction only]; Region: COG0313 1089446001947 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 1089446001948 putative SAM binding site [chemical binding]; other site 1089446001949 putative homodimer interface [polypeptide binding]; other site 1089446001950 methionyl-tRNA synthetase; Reviewed; Region: PRK12268 1089446001951 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 1089446001952 active site 1089446001953 HIGH motif; other site 1089446001954 KMSKS motif; other site 1089446001955 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 1089446001956 tRNA binding surface [nucleotide binding]; other site 1089446001957 anticodon binding site; other site 1089446001958 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 1089446001959 active site 1089446001960 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3583 1089446001961 Domain of unknown function (DUF348); Region: DUF348; pfam03990 1089446001962 Domain of unknown function (DUF348); Region: DUF348; pfam03990 1089446001963 G5 domain; Region: G5; pfam07501 1089446001964 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 1089446001965 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 1089446001966 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1089446001967 S-adenosylmethionine binding site [chemical binding]; other site 1089446001968 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK03188 1089446001969 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1089446001970 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1089446001971 ABC transporter; Region: ABC_tran_2; pfam12848 1089446001972 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1089446001973 Uncharacterized conserved protein [Function unknown]; Region: COG1359 1089446001974 polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707 1089446001975 Nicotinamide mononucleotide transporter [Coenzyme metabolism]; Region: PnuC; COG3201 1089446001976 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1089446001977 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1089446001978 active site 1089446001979 motif I; other site 1089446001980 motif II; other site 1089446001981 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1089446001982 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 1089446001983 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1089446001984 substrate binding site [chemical binding]; other site 1089446001985 oxyanion hole (OAH) forming residues; other site 1089446001986 trimer interface [polypeptide binding]; other site 1089446001987 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 1089446001988 glyceraldehyde-3-phosphate dehydrogenase; Reviewed; Region: PRK08289 1089446001989 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 1089446001990 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1089446001991 proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249 1089446001992 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 1089446001993 Peptide chain release factor RF-3 [Translation, ribosomal structure and biogenesis]; Region: PrfC; COG4108 1089446001994 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 1089446001995 G1 box; other site 1089446001996 putative GEF interaction site [polypeptide binding]; other site 1089446001997 GTP/Mg2+ binding site [chemical binding]; other site 1089446001998 Switch I region; other site 1089446001999 G2 box; other site 1089446002000 G3 box; other site 1089446002001 Switch II region; other site 1089446002002 G4 box; other site 1089446002003 G5 box; other site 1089446002004 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787 1089446002005 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1089446002006 light-dependent protochlorophyllide reductase; Region: LPOR; TIGR01289 1089446002007 NAD(P) binding site [chemical binding]; other site 1089446002008 active site 1089446002009 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 1089446002010 putative active site [active] 1089446002011 catalytic residue [active] 1089446002012 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 1089446002013 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 1089446002014 FMN binding site [chemical binding]; other site 1089446002015 substrate binding site [chemical binding]; other site 1089446002016 putative catalytic residue [active] 1089446002017 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 1089446002018 putative active site [active] 1089446002019 catalytic residue [active] 1089446002020 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 1089446002021 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 1089446002022 5S rRNA interface [nucleotide binding]; other site 1089446002023 CTC domain interface [polypeptide binding]; other site 1089446002024 L16 interface [polypeptide binding]; other site 1089446002025 pullulanase, type I; Region: pulA_typeI; TIGR02104 1089446002026 Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860 1089446002027 Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341 1089446002028 Ca binding site [ion binding]; other site 1089446002029 active site 1089446002030 catalytic site [active] 1089446002031 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 1089446002032 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK03092 1089446002033 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1089446002034 active site 1089446002035 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14352 1089446002036 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 1089446002037 Substrate binding site; other site 1089446002038 Mg++ binding site; other site 1089446002039 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 1089446002040 active site 1089446002041 substrate binding site [chemical binding]; other site 1089446002042 CoA binding site [chemical binding]; other site 1089446002043 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 1089446002044 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 1089446002045 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 1089446002046 The Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_like_2; cd09320 1089446002047 gating phenylalanine in ion channel; other site 1089446002048 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1089446002049 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1089446002050 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 1089446002051 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 1089446002052 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1089446002053 ATP binding site [chemical binding]; other site 1089446002054 putative Mg++ binding site [ion binding]; other site 1089446002055 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1089446002056 nucleotide binding region [chemical binding]; other site 1089446002057 ATP-binding site [chemical binding]; other site 1089446002058 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 1089446002059 transporter, basic amino acid/polyamine antiporter (APA) family; Region: 2A0302; TIGR00905 1089446002060 Spore germination protein; Region: Spore_permease; cl17796 1089446002061 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 1089446002062 homodimer interface [polypeptide binding]; other site 1089446002063 metal binding site [ion binding]; metal-binding site 1089446002064 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1089446002065 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1089446002066 enolase; Provisional; Region: eno; PRK00077 1089446002067 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 1089446002068 dimer interface [polypeptide binding]; other site 1089446002069 metal binding site [ion binding]; metal-binding site 1089446002070 substrate binding pocket [chemical binding]; other site 1089446002071 Septum formation initiator; Region: DivIC; pfam04977 1089446002072 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 1089446002073 Uncharacterized conserved protein [Function unknown]; Region: COG1507 1089446002074 Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248 1089446002075 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 1089446002076 Helix-turn-helix domain; Region: HTH_18; pfam12833 1089446002077 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1089446002078 Bax inhibitor 1 like; Region: BaxI_1; cl17691 1089446002079 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 1089446002080 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 1089446002081 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1089446002082 Domain of unknown function (DUF4307); Region: DUF4307; pfam14155 1089446002083 mycothiol conjugate amidase Mca; Region: mycothiol_Mca; TIGR03446 1089446002084 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 1089446002085 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 1089446002086 catalytic residue [active] 1089446002087 putative FPP diphosphate binding site; other site 1089446002088 putative FPP binding hydrophobic cleft; other site 1089446002089 dimer interface [polypeptide binding]; other site 1089446002090 putative IPP diphosphate binding site; other site 1089446002091 Flavodoxin domain; Region: Flavodoxin_5; pfam12724 1089446002092 pantothenate kinase; Provisional; Region: PRK05439 1089446002093 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 1089446002094 ATP-binding site [chemical binding]; other site 1089446002095 CoA-binding site [chemical binding]; other site 1089446002096 Mg2+-binding site [ion binding]; other site 1089446002097 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 1089446002098 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 1089446002099 dimer interface [polypeptide binding]; other site 1089446002100 active site 1089446002101 glycine-pyridoxal phosphate binding site [chemical binding]; other site 1089446002102 folate binding site [chemical binding]; other site 1089446002103 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1089446002104 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1089446002105 putative substrate translocation pore; other site 1089446002106 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1089446002107 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1089446002108 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1089446002109 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1089446002110 dimerization interface [polypeptide binding]; other site 1089446002111 Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479 1089446002112 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 1089446002113 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1089446002114 Coenzyme A binding pocket [chemical binding]; other site 1089446002115 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1089446002116 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1089446002117 putative substrate translocation pore; other site 1089446002118 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1089446002119 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1089446002120 fumarate hydratase; Reviewed; Region: fumC; PRK00485 1089446002121 Class II fumarases; Region: Fumarase_classII; cd01362 1089446002122 active site 1089446002123 tetramer interface [polypeptide binding]; other site 1089446002124 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 1089446002125 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 1089446002126 putative active site [active] 1089446002127 Protein of unknown function (DUF4245); Region: DUF4245; pfam14030 1089446002128 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 1089446002129 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 1089446002130 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 1089446002131 generic binding surface II; other site 1089446002132 generic binding surface I; other site 1089446002133 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 1089446002134 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 1089446002135 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1089446002136 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1089446002137 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1089446002138 GTP-binding protein YchF; Reviewed; Region: PRK09601 1089446002139 YchF GTPase; Region: YchF; cd01900 1089446002140 G1 box; other site 1089446002141 GTP/Mg2+ binding site [chemical binding]; other site 1089446002142 Switch I region; other site 1089446002143 G2 box; other site 1089446002144 Switch II region; other site 1089446002145 G3 box; other site 1089446002146 G4 box; other site 1089446002147 G5 box; other site 1089446002148 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 1089446002149 Protein of unknown function, DUF488; Region: DUF488; pfam04343 1089446002150 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 1089446002151 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 1089446002152 PhnA protein; Region: PhnA; pfam03831 1089446002153 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1089446002154 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1089446002155 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1089446002156 Walker A/P-loop; other site 1089446002157 ATP binding site [chemical binding]; other site 1089446002158 Q-loop/lid; other site 1089446002159 ABC transporter signature motif; other site 1089446002160 Walker B; other site 1089446002161 D-loop; other site 1089446002162 H-loop/switch region; other site 1089446002163 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 1089446002164 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1089446002165 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1089446002166 Walker A/P-loop; other site 1089446002167 ATP binding site [chemical binding]; other site 1089446002168 Q-loop/lid; other site 1089446002169 ABC transporter signature motif; other site 1089446002170 Walker B; other site 1089446002171 D-loop; other site 1089446002172 H-loop/switch region; other site 1089446002173 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1089446002174 Walker A/P-loop; other site 1089446002175 ATP binding site [chemical binding]; other site 1089446002176 Q-loop/lid; other site 1089446002177 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1089446002178 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1089446002179 Walker A/P-loop; other site 1089446002180 ATP binding site [chemical binding]; other site 1089446002181 Q-loop/lid; other site 1089446002182 ABC transporter; Region: ABC_tran; pfam00005 1089446002183 ABC transporter signature motif; other site 1089446002184 Walker B; other site 1089446002185 D-loop; other site 1089446002186 H-loop/switch region; other site 1089446002187 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2354 1089446002188 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 1089446002189 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 1089446002190 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 1089446002191 ABC-type cobalt transport system, permease component; Region: ABC_cobalt; cl01943 1089446002192 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1089446002193 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1089446002194 Walker A/P-loop; other site 1089446002195 ATP binding site [chemical binding]; other site 1089446002196 Q-loop/lid; other site 1089446002197 ABC transporter signature motif; other site 1089446002198 Walker B; other site 1089446002199 D-loop; other site 1089446002200 H-loop/switch region; other site 1089446002201 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1089446002202 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 1089446002203 Walker A/P-loop; other site 1089446002204 ATP binding site [chemical binding]; other site 1089446002205 Q-loop/lid; other site 1089446002206 ABC transporter signature motif; other site 1089446002207 Walker B; other site 1089446002208 D-loop; other site 1089446002209 H-loop/switch region; other site 1089446002210 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 1089446002211 hypothetical protein; Provisional; Region: PRK06547 1089446002212 Predicted kinase [General function prediction only]; Region: COG0645 1089446002213 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_31; cd04690 1089446002214 nudix motif; other site 1089446002215 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1089446002216 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 1089446002217 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1089446002218 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1089446002219 dimer interface [polypeptide binding]; other site 1089446002220 conserved gate region; other site 1089446002221 ABC-ATPase subunit interface; other site 1089446002222 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1089446002223 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1089446002224 dimer interface [polypeptide binding]; other site 1089446002225 conserved gate region; other site 1089446002226 putative PBP binding loops; other site 1089446002227 ABC-ATPase subunit interface; other site 1089446002228 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 1089446002229 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1089446002230 Walker A/P-loop; other site 1089446002231 ATP binding site [chemical binding]; other site 1089446002232 Q-loop/lid; other site 1089446002233 ABC transporter signature motif; other site 1089446002234 Walker B; other site 1089446002235 D-loop; other site 1089446002236 H-loop/switch region; other site 1089446002237 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1089446002238 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1089446002239 Walker A/P-loop; other site 1089446002240 ATP binding site [chemical binding]; other site 1089446002241 Q-loop/lid; other site 1089446002242 ABC transporter signature motif; other site 1089446002243 Walker B; other site 1089446002244 D-loop; other site 1089446002245 H-loop/switch region; other site 1089446002246 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1089446002247 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 1089446002248 cleavage site 1089446002249 active site 1089446002250 substrate binding sites [chemical binding]; other site 1089446002251 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 1089446002252 ArsC family; Region: ArsC; pfam03960 1089446002253 catalytic residues [active] 1089446002254 Protein of unknown function (DUF402); Region: DUF402; cl00979 1089446002255 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 1089446002256 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 1089446002257 G1 box; other site 1089446002258 GTP/Mg2+ binding site [chemical binding]; other site 1089446002259 G2 box; other site 1089446002260 Switch I region; other site 1089446002261 G3 box; other site 1089446002262 Switch II region; other site 1089446002263 G4 box; other site 1089446002264 G5 box; other site 1089446002265 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 1089446002266 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 1089446002267 The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501 1089446002268 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 1089446002269 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 1089446002270 Ferredoxin [Energy production and conversion]; Region: COG1146 1089446002271 4Fe-4S binding domain; Region: Fer4; pfam00037 1089446002272 N-succinyldiaminopimelate aminotransferase; Reviewed; Region: PRK07865 1089446002273 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1089446002274 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1089446002275 homodimer interface [polypeptide binding]; other site 1089446002276 catalytic residue [active] 1089446002277 Predicted membrane protein [Function unknown]; Region: COG2246 1089446002278 GtrA-like protein; Region: GtrA; pfam04138 1089446002279 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1089446002280 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1089446002281 active site 1089446002282 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1089446002283 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 1089446002284 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Region: DapD_actino; TIGR03535 1089446002285 Putative 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (THP succinyltransferase), C-terminal left-handed parallel alpha-helix (LbH) domain: This group is composed of mostly uncharacterized proteins containing an N-terminal...; Region: LbH_THP_succinylT_putative; cd04649 1089446002286 putative trimer interface [polypeptide binding]; other site 1089446002287 putative CoA binding site [chemical binding]; other site 1089446002288 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1089446002289 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 1089446002290 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Region: DapD_actino; TIGR03535 1089446002291 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1089446002292 putative trimer interface [polypeptide binding]; other site 1089446002293 putative CoA binding site [chemical binding]; other site 1089446002294 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13007 1089446002295 M20 Peptidase actinobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_actinobac; cd05647 1089446002296 metal binding site [ion binding]; metal-binding site 1089446002297 putative dimer interface [polypeptide binding]; other site 1089446002298 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 1089446002299 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 1089446002300 dihydropteroate synthase; Region: DHPS; TIGR01496 1089446002301 substrate binding pocket [chemical binding]; other site 1089446002302 dimer interface [polypeptide binding]; other site 1089446002303 inhibitor binding site; inhibition site 1089446002304 putative glucosyl-3-phosphoglycerate synthase; Provisional; Region: PRK13915 1089446002305 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1089446002306 DivIVA domain; Region: DivI1A_domain; TIGR03544 1089446002307 Protein of unknown function (DUF3117); Region: DUF3117; pfam11314 1089446002308 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 1089446002309 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1089446002310 S-adenosylmethionine binding site [chemical binding]; other site 1089446002311 Glycosyl hydrolases family 32; Region: Glyco_32; smart00640 1089446002312 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 1089446002313 active site 1089446002314 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 1089446002315 Alpha-acetolactate decarboxylase; Region: AAL_decarboxy; pfam03306 1089446002316 glycogen synthase, Corynebacterium family; Region: glgA_Coryne; TIGR02149 1089446002317 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1089446002318 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00844 1089446002319 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 1089446002320 ligand binding site; other site 1089446002321 oligomer interface; other site 1089446002322 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 1089446002323 dimer interface [polypeptide binding]; other site 1089446002324 N-terminal domain interface [polypeptide binding]; other site 1089446002325 sulfate 1 binding site; other site 1089446002326 Methyltransferase domain; Region: Methyltransf_24; pfam13578 1089446002327 RNA polymerase sigma factor SigE; Reviewed; Region: PRK09647 1089446002328 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1089446002329 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1089446002330 DNA binding residues [nucleotide binding] 1089446002331 sec-independent translocase; Provisional; Region: tatB; PRK00182 1089446002332 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 1089446002333 Domain of unknown function DUF59; Region: DUF59; pfam01883 1089446002334 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 1089446002335 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 1089446002336 Predicted membrane protein [Function unknown]; Region: COG4420 1089446002337 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 1089446002338 MgtE intracellular N domain; Region: MgtE_N; smart00924 1089446002339 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 1089446002340 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 1089446002341 alpha-ketoglutarate decarboxylase; Reviewed; Region: kgd; PRK12270 1089446002342 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1089446002343 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 1089446002344 TPP-binding site [chemical binding]; other site 1089446002345 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 1089446002346 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1089446002347 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1089446002348 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1089446002349 Walker A/P-loop; other site 1089446002350 ATP binding site [chemical binding]; other site 1089446002351 Q-loop/lid; other site 1089446002352 ABC transporter signature motif; other site 1089446002353 Walker B; other site 1089446002354 D-loop; other site 1089446002355 H-loop/switch region; other site 1089446002356 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1089446002357 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1089446002358 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1089446002359 Walker A/P-loop; other site 1089446002360 ATP binding site [chemical binding]; other site 1089446002361 Q-loop/lid; other site 1089446002362 ABC transporter signature motif; other site 1089446002363 Walker B; other site 1089446002364 D-loop; other site 1089446002365 H-loop/switch region; other site 1089446002366 shikimate 5-dehydrogenase; Reviewed; Region: PRK12550 1089446002367 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 1089446002368 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 1089446002369 shikimate binding site; other site 1089446002370 NAD(P) binding site [chemical binding]; other site 1089446002371 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 1089446002372 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1089446002373 substrate binding pocket [chemical binding]; other site 1089446002374 catalytic triad [active] 1089446002375 FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575 1089446002376 Aldose 1-epimerase, similar to Escherichia coli YihR; Region: Aldose_epim_Ec_YihR; cd09022 1089446002377 active site 1089446002378 catalytic residues [active] 1089446002379 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 1089446002380 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u2; cd11478 1089446002381 Na binding site [ion binding]; other site 1089446002382 Galactose-1-phosphate uridylyltransferase [Energy production and conversion]; Region: GalT; COG1085 1089446002383 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 1089446002384 nucleotide binding site/active site [active] 1089446002385 HIT family signature motif; other site 1089446002386 catalytic residue [active] 1089446002387 Galactokinase [Carbohydrate transport and metabolism]; Region: GalK; COG0153 1089446002388 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 1089446002389 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 1089446002390 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 1089446002391 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1089446002392 ATP binding site [chemical binding]; other site 1089446002393 Mg++ binding site [ion binding]; other site 1089446002394 motif III; other site 1089446002395 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1089446002396 nucleotide binding region [chemical binding]; other site 1089446002397 ATP-binding site [chemical binding]; other site 1089446002398 RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499 1089446002399 putative RNA binding site [nucleotide binding]; other site 1089446002400 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 1089446002401 dimer interface [polypeptide binding]; other site 1089446002402 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1089446002403 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 1089446002404 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 1089446002405 Na binding site [ion binding]; other site 1089446002406 SNF2 Helicase protein; Region: DUF3670; pfam12419 1089446002407 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 1089446002408 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1089446002409 ATP binding site [chemical binding]; other site 1089446002410 putative Mg++ binding site [ion binding]; other site 1089446002411 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1089446002412 nucleotide binding region [chemical binding]; other site 1089446002413 ATP-binding site [chemical binding]; other site 1089446002414 Uncharacterized conserved protein [Function unknown]; Region: COG4279 1089446002415 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 1089446002416 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 1089446002417 active site 1089446002418 metal binding site [ion binding]; metal-binding site 1089446002419 DNA binding site [nucleotide binding] 1089446002420 AAA domain; Region: AAA_23; pfam13476 1089446002421 Uncharacterized conserved protein [Function unknown]; Region: COG2353 1089446002422 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1089446002423 MarR family; Region: MarR_2; pfam12802 1089446002424 PspC domain; Region: PspC; pfam04024 1089446002425 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1089446002426 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 1089446002427 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1089446002428 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 1089446002429 Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139 1089446002430 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 1089446002431 Domain of unknown function (DUF3390); Region: DUF3390; pfam11870 1089446002432 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 1089446002433 Cysteine-rich domain; Region: CCG; pfam02754 1089446002434 Cysteine-rich domain; Region: CCG; pfam02754 1089446002435 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 1089446002436 L-lactate permease; Region: Lactate_perm; cl00701 1089446002437 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 1089446002438 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 1089446002439 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 1089446002440 active site 1089446002441 HIGH motif; other site 1089446002442 KMSK motif region; other site 1089446002443 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 1089446002444 tRNA binding surface [nucleotide binding]; other site 1089446002445 anticodon binding site; other site 1089446002446 diaminopimelate decarboxylase; Region: lysA; TIGR01048 1089446002447 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 1089446002448 active site 1089446002449 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1089446002450 substrate binding site [chemical binding]; other site 1089446002451 catalytic residues [active] 1089446002452 dimer interface [polypeptide binding]; other site 1089446002453 homoserine dehydrogenase; Provisional; Region: PRK06349 1089446002454 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 1089446002455 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 1089446002456 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 1089446002457 homoserine kinase; Provisional; Region: PRK01212 1089446002458 Predicted transcriptional regulator [Transcription]; Region: COG2345 1089446002459 Protein of unknown function (DUF3489); Region: DUF3489; pfam11994 1089446002460 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK05620 1089446002461 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1089446002462 acyl-activating enzyme (AAE) consensus motif; other site 1089446002463 AMP binding site [chemical binding]; other site 1089446002464 active site 1089446002465 CoA binding site [chemical binding]; other site 1089446002466 transcription termination factor Rho; Provisional; Region: PRK12678 1089446002467 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 1089446002468 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1089446002469 RNA binding site [nucleotide binding]; other site 1089446002470 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 1089446002471 multimer interface [polypeptide binding]; other site 1089446002472 Walker A motif; other site 1089446002473 ATP binding site [chemical binding]; other site 1089446002474 Walker B motif; other site 1089446002475 peptide chain release factor 1; Validated; Region: prfA; PRK00591 1089446002476 This domain is found in peptide chain release factors; Region: PCRF; smart00937 1089446002477 RF-1 domain; Region: RF-1; pfam00472 1089446002478 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 1089446002479 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1089446002480 S-adenosylmethionine binding site [chemical binding]; other site 1089446002481 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 1089446002482 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 1089446002483 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 1089446002484 Mg++ binding site [ion binding]; other site 1089446002485 putative catalytic motif [active] 1089446002486 substrate binding site [chemical binding]; other site 1089446002487 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 1089446002488 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 1089446002489 F0F1 ATP synthase subunit C; Validated; Region: PRK07874 1089446002490 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 1089446002491 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 1089446002492 F0F1 ATP synthase subunit delta; Provisional; Region: PRK13430 1089446002493 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 1089446002494 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 1089446002495 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1089446002496 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 1089446002497 beta subunit interaction interface [polypeptide binding]; other site 1089446002498 Walker A motif; other site 1089446002499 ATP binding site [chemical binding]; other site 1089446002500 Walker B motif; other site 1089446002501 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1089446002502 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 1089446002503 core domain interface [polypeptide binding]; other site 1089446002504 delta subunit interface [polypeptide binding]; other site 1089446002505 epsilon subunit interface [polypeptide binding]; other site 1089446002506 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 1089446002507 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1089446002508 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 1089446002509 alpha subunit interaction interface [polypeptide binding]; other site 1089446002510 Walker A motif; other site 1089446002511 ATP binding site [chemical binding]; other site 1089446002512 Walker B motif; other site 1089446002513 inhibitor binding site; inhibition site 1089446002514 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1089446002515 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 1089446002516 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 1089446002517 gamma subunit interface [polypeptide binding]; other site 1089446002518 epsilon subunit interface [polypeptide binding]; other site 1089446002519 LBP interface [polypeptide binding]; other site 1089446002520 Protein of unknown function (DUF2550); Region: DUF2550; pfam10739 1089446002521 Predicted nuclease of the RecB family [DNA replication, recombination, and repair]; Region: COG1637 1089446002522 hypothetical protein; Provisional; Region: PRK03298 1089446002523 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 1089446002524 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1089446002525 dimer interface [polypeptide binding]; other site 1089446002526 substrate binding site [chemical binding]; other site 1089446002527 metal binding site [ion binding]; metal-binding site 1089446002528 Domain of unknown function DUF77; Region: DUF77; pfam01910 1089446002529 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 1089446002530 ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956 1089446002531 glycogen branching enzyme; Provisional; Region: PRK05402 1089446002532 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 1089446002533 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 1089446002534 active site 1089446002535 catalytic site [active] 1089446002536 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 1089446002537 Domain of unknown function (DUF3416); Region: DUF3416; pfam11896 1089446002538 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 1089446002539 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 1089446002540 active site 1089446002541 catalytic site [active] 1089446002542 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1089446002543 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1089446002544 Walker A/P-loop; other site 1089446002545 ATP binding site [chemical binding]; other site 1089446002546 ABC transporter signature motif; other site 1089446002547 Walker B; other site 1089446002548 D-loop; other site 1089446002549 H-loop/switch region; other site 1089446002550 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 1089446002551 Ligand binding site [chemical binding]; other site 1089446002552 Electron transfer flavoprotein domain; Region: ETF; pfam01012 1089446002553 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 1089446002554 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 1089446002555 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 1089446002556 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 1089446002557 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 1089446002558 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1089446002559 catalytic residue [active] 1089446002560 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1089446002561 S-adenosylmethionine binding site [chemical binding]; other site 1089446002562 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 1089446002563 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 1089446002564 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 1089446002565 active site 1089446002566 catalytic site [active] 1089446002567 substrate binding site [chemical binding]; other site 1089446002568 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 1089446002569 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 1089446002570 nucleotide binding pocket [chemical binding]; other site 1089446002571 K-X-D-G motif; other site 1089446002572 catalytic site [active] 1089446002573 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 1089446002574 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 1089446002575 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 1089446002576 Dimer interface [polypeptide binding]; other site 1089446002577 BRCT sequence motif; other site 1089446002578 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 1089446002579 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 1089446002580 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 1089446002581 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 1089446002582 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1089446002583 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1089446002584 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1089446002585 putative substrate translocation pore; other site 1089446002586 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1089446002587 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1089446002588 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1089446002589 ABC-ATPase subunit interface; other site 1089446002590 dimer interface [polypeptide binding]; other site 1089446002591 putative PBP binding regions; other site 1089446002592 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1089446002593 anchored repeat-type ABC transporter, ATP-binding subunit; Region: anch_rpt_ABC; TIGR03771 1089446002594 Walker A/P-loop; other site 1089446002595 ATP binding site [chemical binding]; other site 1089446002596 Q-loop/lid; other site 1089446002597 ABC transporter signature motif; other site 1089446002598 Walker B; other site 1089446002599 D-loop; other site 1089446002600 H-loop/switch region; other site 1089446002601 Metal binding protein TroA_a. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and...; Region: TroA_a; cd01148 1089446002602 proposed F420-0 ABC transporter, periplasmic F420-0 binding protein; Region: F420-O_ABCperi; TIGR03868 1089446002603 putative ligand binding residues [chemical binding]; other site 1089446002604 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 1089446002605 phosphofructokinase; Region: PFK_mixed; TIGR02483 1089446002606 active site 1089446002607 ADP/pyrophosphate binding site [chemical binding]; other site 1089446002608 dimerization interface [polypeptide binding]; other site 1089446002609 allosteric effector site; other site 1089446002610 fructose-1,6-bisphosphate binding site; other site 1089446002611 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 1089446002612 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 1089446002613 GatB domain; Region: GatB_Yqey; smart00845 1089446002614 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1089446002615 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1089446002616 active site 1089446002617 catalytic tetrad [active] 1089446002618 Lysine efflux permease [General function prediction only]; Region: COG1279 1089446002619 chromosome replication initiation inhibitor protein; Validated; Region: PRK03635 1089446002620 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1089446002621 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1089446002622 dimerization interface [polypeptide binding]; other site 1089446002623 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 1089446002624 Predicted membrane protein [Function unknown]; Region: COG2259 1089446002625 dihydroxy-acid dehydratase; Provisional; Region: PRK12448 1089446002626 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 1089446002627 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1089446002628 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1089446002629 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 1089446002630 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 1089446002631 putative valine binding site [chemical binding]; other site 1089446002632 dimer interface [polypeptide binding]; other site 1089446002633 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 1089446002634 ketol-acid reductoisomerase; Provisional; Region: PRK05479 1089446002635 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 1089446002636 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 1089446002637 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 1089446002638 Uncharacterized conserved protein [Function unknown]; Region: COG1479 1089446002639 Protein of unknown function DUF262; Region: DUF262; pfam03235 1089446002640 Uncharacterized conserved protein [Function unknown]; Region: COG3472 1089446002641 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 1089446002642 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 1089446002643 ligand binding site [chemical binding]; other site 1089446002644 NAD binding site [chemical binding]; other site 1089446002645 dimerization interface [polypeptide binding]; other site 1089446002646 catalytic site [active] 1089446002647 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 1089446002648 putative L-serine binding site [chemical binding]; other site 1089446002649 3-isopropylmalate dehydrogenase; Provisional; Region: PRK03437 1089446002650 tartrate dehydrogenase; Region: TTC; TIGR02089 1089446002651 Predicted signal-transduction protein containing cAMP-binding and CBS domains [Signal transduction mechanisms]; Region: COG2905 1089446002652 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1089446002653 ligand binding site [chemical binding]; other site 1089446002654 flexible hinge region; other site 1089446002655 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with either the CAP_ED (cAMP receptor protein effector domain) family of transcription factors and the DUF294 domain or the PB1 (Phox and Bem1p) domain; Region: CBS_pair_CAP-ED_DUF294_PBI_assoc2; cd04800 1089446002656 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 1089446002657 metal binding triad; other site 1089446002658 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 1089446002659 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 1089446002660 active site 1089446002661 catalytic site [active] 1089446002662 substrate binding site [chemical binding]; other site 1089446002663 Domain of unknown function (DUF2437); Region: DUF2437; pfam10370 1089446002664 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 1089446002665 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1089446002666 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1089446002667 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 1089446002668 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1089446002669 active site 1089446002670 HIGH motif; other site 1089446002671 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1089446002672 active site 1089446002673 KMSKS motif; other site 1089446002674 Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509 1089446002675 Cutinase; Region: Cutinase; pfam01083 1089446002676 biotin synthase; Region: bioB; TIGR00433 1089446002677 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1089446002678 FeS/SAM binding site; other site 1089446002679 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 1089446002680 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 1089446002681 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1089446002682 Zn2+ binding site [ion binding]; other site 1089446002683 Mg2+ binding site [ion binding]; other site 1089446002684 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 1089446002685 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1089446002686 Bacterial transcriptional regulator; Region: IclR; pfam01614 1089446002687 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 1089446002688 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 1089446002689 substrate binding site [chemical binding]; other site 1089446002690 ligand binding site [chemical binding]; other site 1089446002691 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 1089446002692 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 1089446002693 substrate binding site [chemical binding]; other site 1089446002694 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 1089446002695 active site 1089446002696 Ap6A binding site [chemical binding]; other site 1089446002697 nudix motif; other site 1089446002698 metal binding site [ion binding]; metal-binding site 1089446002699 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1089446002700 catalytic core [active] 1089446002701 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 1089446002702 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1089446002703 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 1089446002704 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 1089446002705 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 1089446002706 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1089446002707 Protein of unknown function (DUF3515); Region: DUF3515; pfam12028 1089446002708 Protein of unknown function (DUF3515); Region: DUF3515; pfam12028 1089446002709 thiamine monophosphate kinase; Provisional; Region: PRK05731 1089446002710 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 1089446002711 ATP binding site [chemical binding]; other site 1089446002712 dimerization interface [polypeptide binding]; other site 1089446002713 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 1089446002714 ligand binding site [chemical binding]; other site 1089446002715 active site 1089446002716 UGI interface [polypeptide binding]; other site 1089446002717 catalytic site [active] 1089446002718 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 1089446002719 DAK2 domain; Region: Dak2; pfam02734 1089446002720 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 1089446002721 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 1089446002722 generic binding surface II; other site 1089446002723 ssDNA binding site; other site 1089446002724 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1089446002725 ATP binding site [chemical binding]; other site 1089446002726 putative Mg++ binding site [ion binding]; other site 1089446002727 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1089446002728 nucleotide binding region [chemical binding]; other site 1089446002729 ATP-binding site [chemical binding]; other site 1089446002730 Biotin carboxyl carrier protein [Lipid metabolism]; Region: AccB; COG0511 1089446002731 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1089446002732 carboxyltransferase (CT) interaction site; other site 1089446002733 biotinylation site [posttranslational modification]; other site 1089446002734 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 1089446002735 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1089446002736 S-adenosylmethionine binding site [chemical binding]; other site 1089446002737 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 1089446002738 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 1089446002739 active site 1089446002740 (T/H)XGH motif; other site 1089446002741 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 1089446002742 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1089446002743 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1089446002744 Walker A/P-loop; other site 1089446002745 ATP binding site [chemical binding]; other site 1089446002746 Q-loop/lid; other site 1089446002747 ABC transporter signature motif; other site 1089446002748 Walker B; other site 1089446002749 D-loop; other site 1089446002750 H-loop/switch region; other site 1089446002751 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1089446002752 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1089446002753 dimer interface [polypeptide binding]; other site 1089446002754 conserved gate region; other site 1089446002755 putative PBP binding loops; other site 1089446002756 ABC-ATPase subunit interface; other site 1089446002757 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1089446002758 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1089446002759 substrate binding pocket [chemical binding]; other site 1089446002760 membrane-bound complex binding site; other site 1089446002761 hinge residues; other site 1089446002762 Domain of unknown function (DUF368); Region: DUF368; pfam04018 1089446002763 DNA polymerase I; Provisional; Region: PRK05755 1089446002764 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 1089446002765 active site 1089446002766 metal binding site 1 [ion binding]; metal-binding site 1089446002767 putative 5' ssDNA interaction site; other site 1089446002768 metal binding site 3; metal-binding site 1089446002769 metal binding site 2 [ion binding]; metal-binding site 1089446002770 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 1089446002771 putative DNA binding site [nucleotide binding]; other site 1089446002772 putative metal binding site [ion binding]; other site 1089446002773 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 1089446002774 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 1089446002775 active site 1089446002776 DNA binding site [nucleotide binding] 1089446002777 catalytic site [active] 1089446002778 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 1089446002779 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1089446002780 S-adenosylmethionine binding site [chemical binding]; other site 1089446002781 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK07899 1089446002782 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 1089446002783 RNA binding site [nucleotide binding]; other site 1089446002784 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 1089446002785 RNA binding site [nucleotide binding]; other site 1089446002786 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1089446002787 RNA binding site [nucleotide binding]; other site 1089446002788 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 1089446002789 RNA binding site [nucleotide binding]; other site 1089446002790 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 1089446002791 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1089446002792 active site turn [active] 1089446002793 phosphorylation site [posttranslational modification] 1089446002794 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1089446002795 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 1089446002796 HPr interaction site; other site 1089446002797 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1089446002798 active site 1089446002799 phosphorylation site [posttranslational modification] 1089446002800 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 1089446002801 ATP-binding [chemical binding]; other site 1089446002802 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 1089446002803 CoA-binding site [chemical binding]; other site 1089446002804 radical SAM protein, BA_1875 family; Region: sam_11; TIGR04053 1089446002805 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1089446002806 FeS/SAM binding site; other site 1089446002807 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 1089446002808 excinuclease ABC subunit B; Provisional; Region: PRK05298 1089446002809 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1089446002810 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1089446002811 nucleotide binding region [chemical binding]; other site 1089446002812 ATP-binding site [chemical binding]; other site 1089446002813 Ultra-violet resistance protein B; Region: UvrB; pfam12344 1089446002814 UvrB/uvrC motif; Region: UVR; pfam02151 1089446002815 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1089446002816 Ligand Binding Site [chemical binding]; other site 1089446002817 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 1089446002818 Part of AAA domain; Region: AAA_19; pfam13245 1089446002819 Family description; Region: UvrD_C_2; pfam13538 1089446002820 Predicted membrane protein [Function unknown]; Region: COG2259 1089446002821 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1089446002822 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 1089446002823 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1089446002824 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1089446002825 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 1089446002826 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 1089446002827 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 1089446002828 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 1089446002829 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 1089446002830 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 1089446002831 23S rRNA binding site [nucleotide binding]; other site 1089446002832 L21 binding site [polypeptide binding]; other site 1089446002833 L13 binding site [polypeptide binding]; other site 1089446002834 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 1089446002835 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 1089446002836 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1089446002837 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 1089446002838 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 1089446002839 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 1089446002840 dimer interface [polypeptide binding]; other site 1089446002841 motif 1; other site 1089446002842 active site 1089446002843 motif 2; other site 1089446002844 motif 3; other site 1089446002845 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 1089446002846 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 1089446002847 putative tRNA-binding site [nucleotide binding]; other site 1089446002848 B3/4 domain; Region: B3_4; pfam03483 1089446002849 tRNA synthetase B5 domain; Region: B5; smart00874 1089446002850 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 1089446002851 dimer interface [polypeptide binding]; other site 1089446002852 motif 1; other site 1089446002853 motif 3; other site 1089446002854 motif 2; other site 1089446002855 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 1089446002856 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 1089446002857 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1089446002858 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 1089446002859 heterotetramer interface [polypeptide binding]; other site 1089446002860 active site pocket [active] 1089446002861 cleavage site 1089446002862 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 1089446002863 feedback inhibition sensing region; other site 1089446002864 homohexameric interface [polypeptide binding]; other site 1089446002865 nucleotide binding site [chemical binding]; other site 1089446002866 N-acetyl-L-glutamate binding site [chemical binding]; other site 1089446002867 acetylornithine aminotransferase; Provisional; Region: argD; PRK03244 1089446002868 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1089446002869 inhibitor-cofactor binding pocket; inhibition site 1089446002870 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1089446002871 catalytic residue [active] 1089446002872 ornithine carbamoyltransferase; Provisional; Region: PRK00779 1089446002873 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1089446002874 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1089446002875 arginine repressor; Provisional; Region: PRK03341 1089446002876 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 1089446002877 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 1089446002878 argininosuccinate synthase; Provisional; Region: PRK13820 1089446002879 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 1089446002880 ANP binding site [chemical binding]; other site 1089446002881 Substrate Binding Site II [chemical binding]; other site 1089446002882 Substrate Binding Site I [chemical binding]; other site 1089446002883 argininosuccinate lyase; Provisional; Region: PRK00855 1089446002884 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 1089446002885 active sites [active] 1089446002886 tetramer interface [polypeptide binding]; other site 1089446002887 Uncharacterized conserved protein [Function unknown]; Region: COG2835 1089446002888 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 1089446002889 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 1089446002890 active site 1089446002891 HIGH motif; other site 1089446002892 dimer interface [polypeptide binding]; other site 1089446002893 KMSKS motif; other site 1089446002894 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1089446002895 RNA binding surface [nucleotide binding]; other site 1089446002896 transcription termination factor Rho; Provisional; Region: PRK12678 1089446002897 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 1089446002898 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1089446002899 active site 1089446002900 motif I; other site 1089446002901 motif II; other site 1089446002902 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1089446002903 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 1089446002904 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1089446002905 RNA binding surface [nucleotide binding]; other site 1089446002906 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1089446002907 S-adenosylmethionine binding site [chemical binding]; other site 1089446002908 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03372 1089446002909 ATP-NAD kinase; Region: NAD_kinase; pfam01513 1089446002910 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 1089446002911 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 1089446002912 Walker A/P-loop; other site 1089446002913 ATP binding site [chemical binding]; other site 1089446002914 Q-loop/lid; other site 1089446002915 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 1089446002916 ABC transporter signature motif; other site 1089446002917 Walker B; other site 1089446002918 D-loop; other site 1089446002919 H-loop/switch region; other site 1089446002920 Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4825 1089446002921 Protein of unknown function DUF115; Region: MAF_flag10; cl17471 1089446002922 Protein of unknown function (DUF3186); Region: DUF3186; pfam11382 1089446002923 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 1089446002924 dimer interface [polypeptide binding]; other site 1089446002925 ADP-ribose binding site [chemical binding]; other site 1089446002926 active site 1089446002927 nudix motif; other site 1089446002928 metal binding site [ion binding]; metal-binding site 1089446002929 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 1089446002930 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 1089446002931 active site 1089446002932 Int/Topo IB signature motif; other site 1089446002933 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1089446002934 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1089446002935 P-loop; other site 1089446002936 Magnesium ion binding site [ion binding]; other site 1089446002937 Rec8/ScpA/Scc1-like protein (kleisin family) [Replication, recombination, and repair]; Region: scpA; COG1354 1089446002938 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 1089446002939 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 1089446002940 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1089446002941 adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK05630 1089446002942 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1089446002943 inhibitor-cofactor binding pocket; inhibition site 1089446002944 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1089446002945 catalytic residue [active] 1089446002946 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 1089446002947 AAA domain; Region: AAA_26; pfam13500 1089446002948 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079 1089446002949 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 1089446002950 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1089446002951 RNA binding surface [nucleotide binding]; other site 1089446002952 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 1089446002953 active site 1089446002954 cytidylate kinase; Provisional; Region: cmk; PRK00023 1089446002955 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 1089446002956 CMP-binding site; other site 1089446002957 The sites determining sugar specificity; other site 1089446002958 GTP-binding protein Der; Reviewed; Region: PRK03003 1089446002959 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 1089446002960 G1 box; other site 1089446002961 GTP/Mg2+ binding site [chemical binding]; other site 1089446002962 Switch I region; other site 1089446002963 G2 box; other site 1089446002964 Switch II region; other site 1089446002965 G3 box; other site 1089446002966 G4 box; other site 1089446002967 G5 box; other site 1089446002968 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 1089446002969 G1 box; other site 1089446002970 GTP/Mg2+ binding site [chemical binding]; other site 1089446002971 Switch I region; other site 1089446002972 G2 box; other site 1089446002973 G3 box; other site 1089446002974 Switch II region; other site 1089446002975 G4 box; other site 1089446002976 G5 box; other site 1089446002977 Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704 1089446002978 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK12489 1089446002979 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1089446002980 S-adenosylmethionine binding site [chemical binding]; other site 1089446002981 Predicted esterase [General function prediction only]; Region: COG0627 1089446002982 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 1089446002983 ABC-type Fe3+-citrate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FecB; COG4594 1089446002984 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1089446002985 intersubunit interface [polypeptide binding]; other site 1089446002986 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1089446002987 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1089446002988 dimer interface [polypeptide binding]; other site 1089446002989 ABC-ATPase subunit interface; other site 1089446002990 putative PBP binding regions; other site 1089446002991 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1089446002992 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1089446002993 ABC-ATPase subunit interface; other site 1089446002994 dimer interface [polypeptide binding]; other site 1089446002995 putative PBP binding regions; other site 1089446002996 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1089446002997 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1089446002998 Walker A/P-loop; other site 1089446002999 ATP binding site [chemical binding]; other site 1089446003000 Q-loop/lid; other site 1089446003001 ABC transporter signature motif; other site 1089446003002 Walker B; other site 1089446003003 D-loop; other site 1089446003004 H-loop/switch region; other site 1089446003005 IucA / IucC family; Region: IucA_IucC; pfam04183 1089446003006 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 1089446003007 IucA / IucC family; Region: IucA_IucC; pfam04183 1089446003008 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 1089446003009 H+ Antiporter protein; Region: 2A0121; TIGR00900 1089446003010 hypothetical protein; Provisional; Region: PRK01842 1089446003011 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1089446003012 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1089446003013 preprotein translocase subunit SecA; Reviewed; Region: PRK12326 1089446003014 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1089446003015 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 1089446003016 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1089446003017 nucleotide binding region [chemical binding]; other site 1089446003018 ATP-binding site [chemical binding]; other site 1089446003019 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1089446003020 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1089446003021 phosphopeptide binding site; other site 1089446003022 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 1089446003023 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1089446003024 DNA binding residues [nucleotide binding] 1089446003025 Bifunctional nuclease; Region: DNase-RNase; pfam02577 1089446003026 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 1089446003027 DNA binding residues [nucleotide binding] 1089446003028 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1089446003029 putative dimer interface [polypeptide binding]; other site 1089446003030 Domain of unknown function DUF21; Region: DUF21; pfam01595 1089446003031 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1089446003032 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1089446003033 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1089446003034 Domain of unknown function DUF21; Region: DUF21; pfam01595 1089446003035 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1089446003036 Transporter associated domain; Region: CorC_HlyC; smart01091 1089446003037 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1089446003038 ATP-dependent RNA helicase RhlE; Provisional; Region: PRK10590 1089446003039 ATP binding site [chemical binding]; other site 1089446003040 putative Mg++ binding site [ion binding]; other site 1089446003041 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1089446003042 nucleotide binding region [chemical binding]; other site 1089446003043 ATP-binding site [chemical binding]; other site 1089446003044 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1089446003045 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 1089446003046 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 1089446003047 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1089446003048 CoenzymeA binding site [chemical binding]; other site 1089446003049 subunit interaction site [polypeptide binding]; other site 1089446003050 PHB binding site; other site 1089446003051 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 1089446003052 Mycobacterium tuberculosis CorA-like subfamily; Region: MtCorA-like; cd12830 1089446003053 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 1089446003054 oligomer interface [polypeptide binding]; other site 1089446003055 metal binding site [ion binding]; metal-binding site 1089446003056 metal binding site [ion binding]; metal-binding site 1089446003057 putative Cl binding site [ion binding]; other site 1089446003058 basic sphincter; other site 1089446003059 hydrophobic gate; other site 1089446003060 periplasmic entrance; other site 1089446003061 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1089446003062 S-adenosylmethionine binding site [chemical binding]; other site 1089446003063 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1089446003064 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1089446003065 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1089446003066 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 1089446003067 metabolite-proton symporter; Region: 2A0106; TIGR00883 1089446003068 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1089446003069 putative substrate translocation pore; other site 1089446003070 YceI-like domain; Region: YceI; pfam04264 1089446003071 Domain of unknown function (DUF4109); Region: DUF4109; pfam13397 1089446003072 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 1089446003073 Ligand binding site; other site 1089446003074 Putative Catalytic site; other site 1089446003075 DXD motif; other site 1089446003076 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 1089446003077 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 1089446003078 putative active site [active] 1089446003079 catalytic triad [active] 1089446003080 putative dimer interface [polypeptide binding]; other site 1089446003081 phage T7 F exclusion suppressor FxsA; Reviewed; Region: fxsA; PRK11463 1089446003082 cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK05989 1089446003083 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 1089446003084 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 1089446003085 precorrin-3B synthase; Region: CobG; TIGR02435 1089446003086 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1089446003087 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1089446003088 precorrin-8X methylmutase; Reviewed; Region: cobH; PRK08285 1089446003089 Precorrin-8X methylmutase; Region: CbiC; pfam02570 1089446003090 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 1089446003091 active site 1089446003092 SAM binding site [chemical binding]; other site 1089446003093 homodimer interface [polypeptide binding]; other site 1089446003094 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 1089446003095 active site 1089446003096 SAM binding site [chemical binding]; other site 1089446003097 homodimer interface [polypeptide binding]; other site 1089446003098 cobalt-precorrin-6x reductase; Reviewed; Region: PRK08057 1089446003099 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 1089446003100 Diphthamide biosynthesis methyltransferase [Translation, ribosomal structure and biogenesis]; Region: DPH5; COG1798 1089446003101 active site 1089446003102 SAM binding site [chemical binding]; other site 1089446003103 homodimer interface [polypeptide binding]; other site 1089446003104 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 1089446003105 active site 1089446003106 putative homodimer interface [polypeptide binding]; other site 1089446003107 SAM binding site [chemical binding]; other site 1089446003108 Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242 1089446003109 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1089446003110 S-adenosylmethionine binding site [chemical binding]; other site 1089446003111 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 1089446003112 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1089446003113 NAD(P) binding site [chemical binding]; other site 1089446003114 active site 1089446003115 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 1089446003116 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 1089446003117 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 1089446003118 active site 1089446003119 Superfamily II RNA helicase [DNA replication, recombination, and repair]; Region: COG4581 1089446003120 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1089446003121 ATP binding site [chemical binding]; other site 1089446003122 putative Mg++ binding site [ion binding]; other site 1089446003123 helicase superfamily c-terminal domain; Region: HELICc; smart00490 1089446003124 nucleotide binding region [chemical binding]; other site 1089446003125 ATP-binding site [chemical binding]; other site 1089446003126 DSHCT (NUC185) domain; Region: DSHCT; pfam08148 1089446003127 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 1089446003128 mttA/Hcf106 family; Region: MttA_Hcf106; pfam02416 1089446003129 Predicted transcriptional regulator [Transcription]; Region: COG2378 1089446003130 WYL domain; Region: WYL; pfam13280 1089446003131 Predicted transcriptional regulator [Transcription]; Region: COG2378 1089446003132 WYL domain; Region: WYL; pfam13280 1089446003133 proteasome accessory factor PafA; Region: pupylate_PafA; TIGR03686 1089446003134 Pup-like protein; Region: Pup; pfam05639 1089446003135 Pup-ligase protein; Region: Pup_ligase; cl15463 1089446003136 proteasome ATPase; Region: pup_AAA; TIGR03689 1089446003137 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1089446003138 Walker A motif; other site 1089446003139 ATP binding site [chemical binding]; other site 1089446003140 Walker B motif; other site 1089446003141 arginine finger; other site 1089446003142 tRNA(1-methyladenosine) methyltransferase and related methyltransferases [Translation, ribosomal structure and biogenesis]; Region: GCD14; COG2519 1089446003143 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1089446003144 M18 Peptidase Aspartyl aminopeptidase; Region: M18_DAP; cd05658 1089446003145 Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127 1089446003146 active site 1089446003147 metal binding site [ion binding]; metal-binding site 1089446003148 RecB family exonuclease [DNA replication, recombination, and repair]; Region: COG2887 1089446003149 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 1089446003150 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 1089446003151 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 1089446003152 Potassium binding sites [ion binding]; other site 1089446003153 Cesium cation binding sites [ion binding]; other site 1089446003154 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 1089446003155 Aspartase; Region: Aspartase; cd01357 1089446003156 active sites [active] 1089446003157 tetramer interface [polypeptide binding]; other site 1089446003158 Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704 1089446003159 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK09412 1089446003160 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 1089446003161 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 1089446003162 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 1089446003163 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Mycobacterium tuberculosis phosphoribosyl-ATP pyrophosphohydrolase (HisE or PRATP-PH) and its bacterial homologs; Region: NTP-PPase_HisE; cd11547 1089446003164 homodimer interface [polypeptide binding]; other site 1089446003165 putative metal binding site [ion binding]; other site 1089446003166 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 1089446003167 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1089446003168 motif II; other site 1089446003169 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 1089446003170 5-methyltetrahydrofolate--homocysteine methyltransferase; Region: metH; TIGR02082 1089446003171 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 1089446003172 substrate binding pocket [chemical binding]; other site 1089446003173 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 1089446003174 B12 binding site [chemical binding]; other site 1089446003175 cobalt ligand [ion binding]; other site 1089446003176 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 1089446003177 cysteine--1-D-myo-inosityl 2-amino-2-deoxy-alpha-D-glucopyranoside ligase; Region: mycothiol_MshC; TIGR03447 1089446003178 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1089446003179 active site 1089446003180 HIGH motif; other site 1089446003181 nucleotide binding site [chemical binding]; other site 1089446003182 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1089446003183 active site 1089446003184 KMSKS motif; other site 1089446003185 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 1089446003186 tRNA binding surface [nucleotide binding]; other site 1089446003187 anticodon binding site; other site 1089446003188 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK12554 1089446003189 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1089446003190 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1089446003191 active site 1089446003192 catalytic tetrad [active] 1089446003193 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 1089446003194 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 1089446003195 quinone interaction residues [chemical binding]; other site 1089446003196 active site 1089446003197 catalytic residues [active] 1089446003198 FMN binding site [chemical binding]; other site 1089446003199 substrate binding site [chemical binding]; other site 1089446003200 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 1089446003201 substrate binding site [chemical binding]; other site 1089446003202 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 1089446003203 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 1089446003204 dimerization domain swap beta strand [polypeptide binding]; other site 1089446003205 regulatory protein interface [polypeptide binding]; other site 1089446003206 active site 1089446003207 regulatory phosphorylation site [posttranslational modification]; other site 1089446003208 dihydroxyacetone kinase, phosphoprotein-dependent, L subunit; Region: dha_L_ycgS; TIGR02365 1089446003209 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481 1089446003210 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 1089446003211 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1089446003212 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1089446003213 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 1089446003214 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1089446003215 NAD(P) binding site [chemical binding]; other site 1089446003216 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 1089446003217 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1089446003218 NAD(P) binding site [chemical binding]; other site 1089446003219 active site 1089446003220 Circularly permuted YlqF-related GTPases; Region: YlqF_related_GTPase; cl17249 1089446003221 GTP/Mg2+ binding site [chemical binding]; other site 1089446003222 G4 box; other site 1089446003223 membrane ATPase/protein kinase; Provisional; Region: PRK09435 1089446003224 G5 box; other site 1089446003225 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 1089446003226 Walker A; other site 1089446003227 G1 box; other site 1089446003228 Switch I region; other site 1089446003229 G2 box; other site 1089446003230 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 1089446003231 G4 box; other site 1089446003232 G5 box; other site 1089446003233 methylmalonyl-CoA mutase; Reviewed; Region: PRK09426 1089446003234 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679 1089446003235 active site 1089446003236 substrate binding site [chemical binding]; other site 1089446003237 coenzyme B12 binding site [chemical binding]; other site 1089446003238 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 1089446003239 B12 binding site [chemical binding]; other site 1089446003240 cobalt ligand [ion binding]; other site 1089446003241 methylmalonyl-CoA mutase, heterodimeric type, beta chain; Region: mmCoA_mut_beta; TIGR00642 1089446003242 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Beta subunit-like subfamily; contains bacterial proteins similar to the beta subunit of MCMs from Propionbacterium shermanni and Streptomyces cinnamonensis, which are alpha/beta...; Region: MM_CoA_mutase_beta; cd03677 1089446003243 heterodimer interface [polypeptide binding]; other site 1089446003244 substrate interaction site [chemical binding]; other site 1089446003245 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 1089446003246 Uncharacterized conserved protein [Function unknown]; Region: COG0398 1089446003247 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1089446003248 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 1089446003249 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 1089446003250 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 1089446003251 Protein of unknown function (DUF3097); Region: DUF3097; pfam11296 1089446003252 ferrochelatase; Reviewed; Region: hemH; PRK00035 1089446003253 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 1089446003254 C-terminal domain interface [polypeptide binding]; other site 1089446003255 active site 1089446003256 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 1089446003257 active site 1089446003258 N-terminal domain interface [polypeptide binding]; other site 1089446003259 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1089446003260 NlpC/P60 family; Region: NLPC_P60; pfam00877 1089446003261 pyruvate carboxylase subunit A; Validated; Region: PRK07178 1089446003262 aconitate hydratase; Validated; Region: PRK09277 1089446003263 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 1089446003264 substrate binding site [chemical binding]; other site 1089446003265 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 1089446003266 ligand binding site [chemical binding]; other site 1089446003267 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 1089446003268 substrate binding site [chemical binding]; other site 1089446003269 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 1089446003270 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1089446003271 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 1089446003272 catalytic triad [active] 1089446003273 ACT domain proteins similar to the yet uncharacterized Streptococcus pneumoniae ACT domain protein; Region: ACT_1ZPV; cd04872 1089446003274 Uncharacterized proteins with similarity to Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL_like_DUF711; cd08025 1089446003275 AAA ATPase domain; Region: AAA_16; pfam13191 1089446003276 AAA domain; Region: AAA_22; pfam13401 1089446003277 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1089446003278 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1089446003279 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1089446003280 Walker A/P-loop; other site 1089446003281 ATP binding site [chemical binding]; other site 1089446003282 Q-loop/lid; other site 1089446003283 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1089446003284 ABC transporter signature motif; other site 1089446003285 Walker B; other site 1089446003286 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1089446003287 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 1089446003288 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 1089446003289 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 1089446003290 trimerization site [polypeptide binding]; other site 1089446003291 active site 1089446003292 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1089446003293 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 1089446003294 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1089446003295 catalytic residue [active] 1089446003296 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 1089446003297 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 1089446003298 Walker A/P-loop; other site 1089446003299 ATP binding site [chemical binding]; other site 1089446003300 Q-loop/lid; other site 1089446003301 ABC transporter signature motif; other site 1089446003302 Walker B; other site 1089446003303 D-loop; other site 1089446003304 H-loop/switch region; other site 1089446003305 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 1089446003306 FeS assembly protein SufD; Region: sufD; TIGR01981 1089446003307 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 1089446003308 FeS assembly protein SufB; Region: sufB; TIGR01980 1089446003309 Predicted transcriptional regulator [Transcription]; Region: COG2345 1089446003310 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1089446003311 putative DNA binding site [nucleotide binding]; other site 1089446003312 putative Zn2+ binding site [ion binding]; other site 1089446003313 carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459 1089446003314 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1089446003315 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1089446003316 Walker A/P-loop; other site 1089446003317 ATP binding site [chemical binding]; other site 1089446003318 Q-loop/lid; other site 1089446003319 ABC transporter signature motif; other site 1089446003320 Walker B; other site 1089446003321 D-loop; other site 1089446003322 H-loop/switch region; other site 1089446003323 ABC-2 type transporter; Region: ABC2_membrane; cl17235 1089446003324 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 1089446003325 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 1089446003326 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 1089446003327 UbiA prenyltransferase family; Region: UbiA; pfam01040 1089446003328 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 1089446003329 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 1089446003330 TPP-binding site [chemical binding]; other site 1089446003331 dimer interface [polypeptide binding]; other site 1089446003332 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1089446003333 PYR/PP interface [polypeptide binding]; other site 1089446003334 dimer interface [polypeptide binding]; other site 1089446003335 TPP binding site [chemical binding]; other site 1089446003336 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1089446003337 Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955 1089446003338 putative active site [active] 1089446003339 transaldolase; Provisional; Region: PRK03903 1089446003340 catalytic residue [active] 1089446003341 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 1089446003342 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 1089446003343 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 1089446003344 glucose-6-phosphate dehydrogenase assembly protein OpcA; Region: OpcA; TIGR00534 1089446003345 Glucose-6-phosphate dehydrogenase subunit; Region: OpcA_G6PD_assem; pfam10128 1089446003346 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 1089446003347 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 1089446003348 putative active site [active] 1089446003349 preprotein translocase subunit SecG; Reviewed; Region: secG; PRK06870 1089446003350 phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009 1089446003351 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 1089446003352 triosephosphate isomerase; Provisional; Region: PRK14567 1089446003353 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 1089446003354 substrate binding site [chemical binding]; other site 1089446003355 dimer interface [polypeptide binding]; other site 1089446003356 catalytic triad [active] 1089446003357 Phosphoglycerate kinase; Region: PGK; pfam00162 1089446003358 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 1089446003359 substrate binding site [chemical binding]; other site 1089446003360 hinge regions; other site 1089446003361 ADP binding site [chemical binding]; other site 1089446003362 catalytic site [active] 1089446003363 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 1089446003364 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 1089446003365 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1089446003366 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 1089446003367 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 1089446003368 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 1089446003369 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 1089446003370 phosphate binding site [ion binding]; other site 1089446003371 putative substrate binding pocket [chemical binding]; other site 1089446003372 dimer interface [polypeptide binding]; other site 1089446003373 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 1089446003374 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 1089446003375 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 1089446003376 GIY-YIG motif/motif A; other site 1089446003377 active site 1089446003378 catalytic site [active] 1089446003379 putative DNA binding site [nucleotide binding]; other site 1089446003380 metal binding site [ion binding]; metal-binding site 1089446003381 UvrB/uvrC motif; Region: UVR; pfam02151 1089446003382 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 1089446003383 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 1089446003384 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 1089446003385 homopentamer interface [polypeptide binding]; other site 1089446003386 active site 1089446003387 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 1089446003388 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 1089446003389 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 1089446003390 dimerization interface [polypeptide binding]; other site 1089446003391 active site 1089446003392 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 1089446003393 Lumazine binding domain; Region: Lum_binding; pfam00677 1089446003394 Lumazine binding domain; Region: Lum_binding; pfam00677 1089446003395 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 1089446003396 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 1089446003397 catalytic motif [active] 1089446003398 Zn binding site [ion binding]; other site 1089446003399 RibD C-terminal domain; Region: RibD_C; pfam01872 1089446003400 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 1089446003401 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 1089446003402 substrate binding site [chemical binding]; other site 1089446003403 hexamer interface [polypeptide binding]; other site 1089446003404 metal binding site [ion binding]; metal-binding site 1089446003405 16S rRNA methyltransferase B; Provisional; Region: PRK14902 1089446003406 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 1089446003407 putative RNA binding site [nucleotide binding]; other site 1089446003408 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1089446003409 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 1089446003410 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 1089446003411 putative active site [active] 1089446003412 substrate binding site [chemical binding]; other site 1089446003413 putative cosubstrate binding site; other site 1089446003414 catalytic site [active] 1089446003415 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 1089446003416 substrate binding site [chemical binding]; other site 1089446003417 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 1089446003418 active site 1089446003419 catalytic residues [active] 1089446003420 metal binding site [ion binding]; metal-binding site 1089446003421 primosome assembly protein PriA; Provisional; Region: PRK14873 1089446003422 S-adenosylmethionine synthetase; Validated; Region: PRK05250 1089446003423 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 1089446003424 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 1089446003425 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 1089446003426 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 1089446003427 Flavoprotein; Region: Flavoprotein; pfam02441 1089446003428 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 1089446003429 DNA-directed RNA polymerase, subunit K/omega [Transcription]; Region: RpoZ; COG1758 1089446003430 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 1089446003431 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 1089446003432 catalytic site [active] 1089446003433 G-X2-G-X-G-K; other site 1089446003434 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 1089446003435 active site 1089446003436 dimer interface [polypeptide binding]; other site 1089446003437 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 1089446003438 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1089446003439 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1089446003440 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 1089446003441 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1089446003442 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1089446003443 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 1089446003444 IMP binding site; other site 1089446003445 dimer interface [polypeptide binding]; other site 1089446003446 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 1089446003447 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 1089446003448 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 1089446003449 catalytic site [active] 1089446003450 subunit interface [polypeptide binding]; other site 1089446003451 dihydroorotase; Validated; Region: pyrC; PRK09357 1089446003452 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1089446003453 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 1089446003454 active site 1089446003455 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 1089446003456 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1089446003457 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1089446003458 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 1089446003459 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1089446003460 active site 1089446003461 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_3; cd07820 1089446003462 putative hydrophobic ligand binding site [chemical binding]; other site 1089446003463 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1089446003464 TIGR01777 family protein; Region: yfcH 1089446003465 NAD(P) binding site [chemical binding]; other site 1089446003466 active site 1089446003467 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 1089446003468 transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202 1089446003469 putative RNA binding site [nucleotide binding]; other site 1089446003470 elongation factor P; Validated; Region: PRK00529 1089446003471 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 1089446003472 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 1089446003473 RNA binding site [nucleotide binding]; other site 1089446003474 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 1089446003475 RNA binding site [nucleotide binding]; other site 1089446003476 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 1089446003477 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 1089446003478 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 1089446003479 active site 1089446003480 Dehydroquinase class II; Region: DHquinase_II; pfam01220 1089446003481 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 1089446003482 trimer interface [polypeptide binding]; other site 1089446003483 active site 1089446003484 dimer interface [polypeptide binding]; other site 1089446003485 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 1089446003486 active site 1089446003487 dimer interface [polypeptide binding]; other site 1089446003488 metal binding site [ion binding]; metal-binding site 1089446003489 shikimate kinase; Reviewed; Region: aroK; PRK00131 1089446003490 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 1089446003491 ADP binding site [chemical binding]; other site 1089446003492 magnesium binding site [ion binding]; other site 1089446003493 putative shikimate binding site; other site 1089446003494 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 1089446003495 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 1089446003496 Tetramer interface [polypeptide binding]; other site 1089446003497 active site 1089446003498 FMN-binding site [chemical binding]; other site 1089446003499 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 1089446003500 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 1089446003501 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 1089446003502 shikimate binding site; other site 1089446003503 NAD(P) binding site [chemical binding]; other site 1089446003504 Aminodeoxychorismate lyase [Coenzyme transport and metabolism]; Region: COG1559 1089446003505 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 1089446003506 dimerization interface [polypeptide binding]; other site 1089446003507 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 1089446003508 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 1089446003509 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 1089446003510 motif 1; other site 1089446003511 active site 1089446003512 motif 2; other site 1089446003513 motif 3; other site 1089446003514 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 1089446003515 DHHA1 domain; Region: DHHA1; pfam02272 1089446003516 recombination factor protein RarA; Reviewed; Region: PRK13342 1089446003517 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1089446003518 Walker A motif; other site 1089446003519 ATP binding site [chemical binding]; other site 1089446003520 Walker B motif; other site 1089446003521 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 1089446003522 Phosphotransferase enzyme family; Region: APH; pfam01636 1089446003523 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1089446003524 substrate binding site [chemical binding]; other site 1089446003525 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 1089446003526 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 1089446003527 dimer interface [polypeptide binding]; other site 1089446003528 anticodon binding site; other site 1089446003529 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 1089446003530 homodimer interface [polypeptide binding]; other site 1089446003531 motif 1; other site 1089446003532 active site 1089446003533 motif 2; other site 1089446003534 GAD domain; Region: GAD; pfam02938 1089446003535 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1089446003536 active site 1089446003537 motif 3; other site 1089446003538 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 1089446003539 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1089446003540 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1089446003541 ATP binding site [chemical binding]; other site 1089446003542 putative Mg++ binding site [ion binding]; other site 1089446003543 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1089446003544 nucleotide binding region [chemical binding]; other site 1089446003545 ATP-binding site [chemical binding]; other site 1089446003546 Predicted membrane protein [Function unknown]; Region: COG1511 1089446003547 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 1089446003548 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 1089446003549 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 1089446003550 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 1089446003551 iron-dicitrate transporter ATP-binding subunit; Provisional; Region: fecE; PRK11231 1089446003552 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1089446003553 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1089446003554 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1089446003555 LLM-partnered FMN reductase, CE1759 family; Region: LLM_duo_CE1759; TIGR04037 1089446003556 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 1089446003557 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 1089446003558 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 1089446003559 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 1089446003560 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 1089446003561 putative active site [active] 1089446003562 putative catalytic site [active] 1089446003563 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1089446003564 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1089446003565 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 1089446003566 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 1089446003567 dimer interface [polypeptide binding]; other site 1089446003568 motif 1; other site 1089446003569 active site 1089446003570 motif 2; other site 1089446003571 motif 3; other site 1089446003572 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 1089446003573 anticodon binding site; other site 1089446003574 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 1089446003575 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 1089446003576 dimer interface [polypeptide binding]; other site 1089446003577 catalytic triad [active] 1089446003578 peroxidatic and resolving cysteines [active] 1089446003579 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 1089446003580 active site 1089446003581 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 1089446003582 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1089446003583 Zn2+ binding site [ion binding]; other site 1089446003584 Mg2+ binding site [ion binding]; other site 1089446003585 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1089446003586 synthetase active site [active] 1089446003587 NTP binding site [chemical binding]; other site 1089446003588 metal binding site [ion binding]; metal-binding site 1089446003589 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 1089446003590 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 1089446003591 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1089446003592 active site 1089446003593 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1089446003594 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 1089446003595 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 1089446003596 Protein export membrane protein; Region: SecD_SecF; pfam02355 1089446003597 Preprotein translocase subunit SecD [Intracellular trafficking and secretion]; Region: SecD; COG0342 1089446003598 Protein export membrane protein; Region: SecD_SecF; cl14618 1089446003599 Preprotein translocase subunit; Region: YajC; pfam02699 1089446003600 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 1089446003601 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1089446003602 Walker A motif; other site 1089446003603 ATP binding site [chemical binding]; other site 1089446003604 Walker B motif; other site 1089446003605 arginine finger; other site 1089446003606 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 1089446003607 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 1089446003608 RuvA N terminal domain; Region: RuvA_N; pfam01330 1089446003609 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 1089446003610 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 1089446003611 active site 1089446003612 putative DNA-binding cleft [nucleotide binding]; other site 1089446003613 dimer interface [polypeptide binding]; other site 1089446003614 hypothetical protein; Validated; Region: PRK00110 1089446003615 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 1089446003616 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 1089446003617 active site 1089446003618 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 1089446003619 catalytic triad [active] 1089446003620 dimer interface [polypeptide binding]; other site 1089446003621 Protein of unknown function (DUF998); Region: DUF998; pfam06197 1089446003622 6-carboxyhexanoate--CoA ligase; Provisional; Region: PRK01322 1089446003623 8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958 1089446003624 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 1089446003625 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1089446003626 catalytic residue [active] 1089446003627 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1089446003628 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1089446003629 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 1089446003630 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 1089446003631 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 1089446003632 putative acyl-acceptor binding pocket; other site 1089446003633 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 1089446003634 FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275 1089446003635 nucleotide binding site/active site [active] 1089446003636 HIT family signature motif; other site 1089446003637 catalytic residue [active] 1089446003638 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305 1089446003639 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 1089446003640 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 1089446003641 active site 1089446003642 dimer interface [polypeptide binding]; other site 1089446003643 motif 1; other site 1089446003644 motif 2; other site 1089446003645 motif 3; other site 1089446003646 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 1089446003647 anticodon binding site; other site 1089446003648 Tat-translocated enzyme; Region: tat_substr_1; TIGR01412 1089446003649 Predicted iron-dependent peroxidase [Inorganic ion transport and metabolism]; Region: COG2837 1089446003650 Protein of unknown function (DUF461); Region: DUF461; pfam04314 1089446003651 Uncharacterized protein, homolog of Cu resistance protein CopC [General function prediction only]; Region: CopC; COG2372 1089446003652 hypothetical protein; Provisional; Region: PRK14059 1089446003653 Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985 1089446003654 Protein of unknown function (DUF2029); Region: DUF2029; pfam09594 1089446003655 Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229 1089446003656 SelR domain; Region: SelR; pfam01641 1089446003657 Predicted heme peroxidase involved in anaerobic stress response [General function prediction only]; Region: ywfI; COG3253 1089446003658 Protein of unknown function (DUF3000); Region: DUF3000; pfam11452 1089446003659 Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349 1089446003660 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 1089446003661 catalytic site [active] 1089446003662 putative active site [active] 1089446003663 putative substrate binding site [chemical binding]; other site 1089446003664 HRDC domain; Region: HRDC; pfam00570 1089446003665 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 1089446003666 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 1089446003667 TPP-binding site; other site 1089446003668 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1089446003669 PYR/PP interface [polypeptide binding]; other site 1089446003670 dimer interface [polypeptide binding]; other site 1089446003671 TPP binding site [chemical binding]; other site 1089446003672 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1089446003673 Predicted RNA-binding protein, contains TRAM domain [General function prediction only]; Region: COG3269 1089446003674 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 1089446003675 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1089446003676 S-adenosylmethionine binding site [chemical binding]; other site 1089446003677 Protein of unknown function (DUF3159); Region: DUF3159; pfam11361 1089446003678 Protein of unknown function (DUF3710); Region: DUF3710; pfam12502 1089446003679 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 1089446003680 trimer interface [polypeptide binding]; other site 1089446003681 active site 1089446003682 Protein of unknown function (DUF3093); Region: DUF3093; pfam11292 1089446003683 Domain of unknown function (DUF4193); Region: DUF4193; pfam13834 1089446003684 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1089446003685 FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289 1089446003686 active site 1089446003687 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1089446003688 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1089446003689 nucleotide binding site [chemical binding]; other site 1089446003690 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921 1089446003691 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 1089446003692 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1089446003693 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1089446003694 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1089446003695 DNA binding residues [nucleotide binding] 1089446003696 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 1089446003697 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1089446003698 ATP binding site [chemical binding]; other site 1089446003699 putative Mg++ binding site [ion binding]; other site 1089446003700 Protein of unknown function (DUF3039); Region: DUF3039; pfam11238 1089446003701 Protein of unknown function (DUF3099); Region: DUF3099; pfam11298 1089446003702 Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis]; Region: HemK; COG2890 1089446003703 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1089446003704 S-adenosylmethionine binding site [chemical binding]; other site 1089446003705 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 1089446003706 putative active site [active] 1089446003707 dimerization interface [polypeptide binding]; other site 1089446003708 putative tRNAtyr binding site [nucleotide binding]; other site 1089446003709 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921 1089446003710 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 1089446003711 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1089446003712 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1089446003713 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1089446003714 DNA binding residues [nucleotide binding] 1089446003715 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 1089446003716 Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529 1089446003717 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 1089446003718 This entry represents the core domain of the ferrous iron (Fe2+) transport protein FeoA found in bacteria; Region: FeoA; smart00899 1089446003719 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 1089446003720 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 1089446003721 NAD binding site [chemical binding]; other site 1089446003722 homodimer interface [polypeptide binding]; other site 1089446003723 active site 1089446003724 substrate binding site [chemical binding]; other site 1089446003725 Domain of unknown function (DUF4192); Region: DUF4192; pfam13830 1089446003726 PAC2 family; Region: PAC2; pfam09754 1089446003727 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1089446003728 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1089446003729 ATP binding site [chemical binding]; other site 1089446003730 putative Mg++ binding site [ion binding]; other site 1089446003731 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1089446003732 nucleotide binding region [chemical binding]; other site 1089446003733 ATP-binding site [chemical binding]; other site 1089446003734 Domain of unknown function (DUF3516); Region: DUF3516; pfam12029 1089446003735 alkylhydroperoxidase, AhpD family; Region: ahpD; TIGR00777 1089446003736 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 1089446003737 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 1089446003738 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 1089446003739 dimer interface [polypeptide binding]; other site 1089446003740 decamer (pentamer of dimers) interface [polypeptide binding]; other site 1089446003741 catalytic triad [active] 1089446003742 peroxidatic and resolving cysteines [active] 1089446003743 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1089446003744 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 1089446003745 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 1089446003746 dimerization interface [polypeptide binding]; other site 1089446003747 Predicted integral membrane protein (DUF2189); Region: DUF2189; cl02291 1089446003748 ATP-dependent helicase HrpA; Region: DEAH_box_HrpA; TIGR01967 1089446003749 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1089446003750 ATP binding site [chemical binding]; other site 1089446003751 putative Mg++ binding site [ion binding]; other site 1089446003752 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1089446003753 nucleotide binding region [chemical binding]; other site 1089446003754 ATP-binding site [chemical binding]; other site 1089446003755 Helicase associated domain (HA2); Region: HA2; pfam04408 1089446003756 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 1089446003757 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 1089446003758 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 1089446003759 ATP cone domain; Region: ATP-cone; pfam03477 1089446003760 LexA repressor; Validated; Region: PRK00215 1089446003761 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 1089446003762 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1089446003763 Catalytic site [active] 1089446003764 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1089446003765 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 1089446003766 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1089446003767 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 1089446003768 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 1089446003769 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1089446003770 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 1089446003771 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1089446003772 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1089446003773 DNA-binding site [nucleotide binding]; DNA binding site 1089446003774 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1089446003775 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 1089446003776 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 1089446003777 putative substrate binding site [chemical binding]; other site 1089446003778 putative ATP binding site [chemical binding]; other site 1089446003779 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1089446003780 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 1089446003781 active site 1089446003782 phosphorylation site [posttranslational modification] 1089446003783 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 1089446003784 active site 1089446003785 P-loop; other site 1089446003786 phosphorylation site [posttranslational modification] 1089446003787 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 1089446003788 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 1089446003789 dimerization domain swap beta strand [polypeptide binding]; other site 1089446003790 regulatory protein interface [polypeptide binding]; other site 1089446003791 active site 1089446003792 regulatory phosphorylation site [posttranslational modification]; other site 1089446003793 putative luciferase-like monooxygenase, FMN-dependent, CE1758 family; Region: LLM_CE1758_fam; TIGR04036 1089446003794 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1089446003795 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1089446003796 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1089446003797 LLM-partnered FMN reductase, CE1759 family; Region: LLM_duo_CE1759; TIGR04037 1089446003798 pyrimidine utilization transport protein G; Region: RutG; TIGR03616 1089446003799 GTPases [General function prediction only]; Region: HflX; COG2262 1089446003800 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 1089446003801 HflX GTPase family; Region: HflX; cd01878 1089446003802 G1 box; other site 1089446003803 GTP/Mg2+ binding site [chemical binding]; other site 1089446003804 Switch I region; other site 1089446003805 G2 box; other site 1089446003806 G3 box; other site 1089446003807 Switch II region; other site 1089446003808 G4 box; other site 1089446003809 G5 box; other site 1089446003810 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 1089446003811 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1089446003812 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1089446003813 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 1089446003814 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 1089446003815 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 1089446003816 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 1089446003817 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 1089446003818 Ribosomal protein L14p/L23e; Region: Ribosomal_L14; cl00328 1089446003819 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14326 1089446003820 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 1089446003821 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1089446003822 FeS/SAM binding site; other site 1089446003823 recombination regulator RecX; Reviewed; Region: recX; PRK00117 1089446003824 recombinase A; Provisional; Region: recA; PRK09354 1089446003825 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 1089446003826 hexamer interface [polypeptide binding]; other site 1089446003827 Walker A motif; other site 1089446003828 ATP binding site [chemical binding]; other site 1089446003829 Walker B motif; other site 1089446003830 Protein of unknown function (DUF3046); Region: DUF3046; pfam11248 1089446003831 BioY family; Region: BioY; pfam02632 1089446003832 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1089446003833 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1089446003834 Walker A/P-loop; other site 1089446003835 ATP binding site [chemical binding]; other site 1089446003836 Q-loop/lid; other site 1089446003837 ABC transporter signature motif; other site 1089446003838 Walker B; other site 1089446003839 D-loop; other site 1089446003840 H-loop/switch region; other site 1089446003841 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 1089446003842 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 1089446003843 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1089446003844 sequence-specific DNA binding site [nucleotide binding]; other site 1089446003845 salt bridge; other site 1089446003846 Uncharacterized protein (competence- and mitomycin-induced) [General function prediction only]; Region: CinA; COG1546 1089446003847 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 1089446003848 YCII-related domain; Region: YCII; cl00999 1089446003849 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 1089446003850 TIGR03085 family protein; Region: TIGR03085 1089446003851 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 1089446003852 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1089446003853 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 1089446003854 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 1089446003855 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 1089446003856 dimer interface [polypeptide binding]; other site 1089446003857 active site 1089446003858 catalytic residue [active] 1089446003859 FAD-dependent thymidylate synthase; Reviewed; Region: thyX; PRK00847 1089446003860 dihydrodipicolinate reductase; Provisional; Region: PRK00048 1089446003861 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 1089446003862 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 1089446003863 guanosine pentaphosphate synthetase I/polynucleotide phosphorylase; Region: pppGpp_PNP; TIGR02696 1089446003864 RNase PH-like 3'-5' exoribonucleases; Region: RNase_PH; cl03114 1089446003865 oligomer interface [polypeptide binding]; other site 1089446003866 RNA binding site [nucleotide binding]; other site 1089446003867 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 1089446003868 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 1089446003869 RNase E interface [polypeptide binding]; other site 1089446003870 trimer interface [polypeptide binding]; other site 1089446003871 active site 1089446003872 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 1089446003873 putative nucleic acid binding region [nucleotide binding]; other site 1089446003874 G-X-X-G motif; other site 1089446003875 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 1089446003876 RNA binding site [nucleotide binding]; other site 1089446003877 domain interface; other site 1089446003878 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 1089446003879 16S/18S rRNA binding site [nucleotide binding]; other site 1089446003880 S13e-L30e interaction site [polypeptide binding]; other site 1089446003881 25S rRNA binding site [nucleotide binding]; other site 1089446003882 NH_hydro_CaPnhB: A subgroup of nucleoside hydrolases similar to Corynebacterium ammoniagenes Purine/pyrimidine nucleoside hydrolase (pnhB). Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These...; Region: nuc_hydro_CaPnhB; cd02650 1089446003883 active site 1089446003884 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 1089446003885 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 1089446003886 active site 1089446003887 Riboflavin kinase; Region: Flavokinase; smart00904 1089446003888 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK03287 1089446003889 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 1089446003890 RNA binding site [nucleotide binding]; other site 1089446003891 active site 1089446003892 tRNA Pseudouridine synthase II, C terminal; Region: TruB_C; pfam09142 1089446003893 Phosphopantetheinyl transferase component of siderophore synthetase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntD; COG2977 1089446003894 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 1089446003895 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1089446003896 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1089446003897 active site 1089446003898 metal binding site [ion binding]; metal-binding site 1089446003899 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 1089446003900 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 1089446003901 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 1089446003902 DHH family; Region: DHH; pfam01368 1089446003903 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 1089446003904 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1089446003905 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1089446003906 Translation initiation factor 2 (IF-2; GTPase) [Translation, ribosomal structure and biogenesis]; Region: InfB; COG0532 1089446003907 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 1089446003908 G1 box; other site 1089446003909 putative GEF interaction site [polypeptide binding]; other site 1089446003910 GTP/Mg2+ binding site [chemical binding]; other site 1089446003911 Switch I region; other site 1089446003912 G2 box; other site 1089446003913 G3 box; other site 1089446003914 Switch II region; other site 1089446003915 G4 box; other site 1089446003916 G5 box; other site 1089446003917 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 1089446003918 Translation-initiation factor 2; Region: IF-2; pfam11987 1089446003919 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 1089446003920 Protein of unknown function (DUF448); Region: DUF448; pfam04296 1089446003921 putative RNA binding cleft [nucleotide binding]; other site 1089446003922 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 1089446003923 NusA N-terminal domain; Region: NusA_N; pfam08529 1089446003924 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 1089446003925 RNA binding site [nucleotide binding]; other site 1089446003926 homodimer interface [polypeptide binding]; other site 1089446003927 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 1089446003928 G-X-X-G motif; other site 1089446003929 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 1089446003930 G-X-X-G motif; other site 1089446003931 Sm and related proteins; Region: Sm_like; cl00259 1089446003932 Uncharacterized BCR, YhbC family COG0779; Region: DUF150; pfam02576 1089446003933 prolyl-tRNA synthetase; Provisional; Region: PRK09194 1089446003934 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 1089446003935 dimer interface [polypeptide binding]; other site 1089446003936 motif 1; other site 1089446003937 active site 1089446003938 motif 2; other site 1089446003939 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 1089446003940 putative deacylase active site [active] 1089446003941 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1089446003942 active site 1089446003943 motif 3; other site 1089446003944 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 1089446003945 anticodon binding site; other site 1089446003946 hypothetical protein; Validated; Region: PRK02101 1089446003947 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 1089446003948 active site 1089446003949 SAM binding site [chemical binding]; other site 1089446003950 homodimer interface [polypeptide binding]; other site 1089446003951 hypothetical protein; Validated; Region: PRK00029 1089446003952 Uncharacterized conserved protein [Function unknown]; Region: COG0397 1089446003953 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 1089446003954 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 1089446003955 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 1089446003956 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 1089446003957 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1089446003958 DNA binding site [nucleotide binding] 1089446003959 active site 1089446003960 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 1089446003961 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 1089446003962 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 1089446003963 catalytic triad [active] 1089446003964 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 1089446003965 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 1089446003966 homodimer interface [polypeptide binding]; other site 1089446003967 Walker A motif; other site 1089446003968 ATP binding site [chemical binding]; other site 1089446003969 hydroxycobalamin binding site [chemical binding]; other site 1089446003970 Walker B motif; other site 1089446003971 Magnesium chelatase: Mg-chelatase catalyses the insertion of Mg into protoporphyrin IX (Proto). In chlorophyll biosynthesis, insertion of Mg2+ into protoporphyrin IX is catalysed by magnesium chelatase in an ATP-dependent reaction. Magnesium chelatase is...; Region: vWA_Magnesium_chelatase; cd01451 1089446003972 metal ion-dependent adhesion site (MIDAS); other site 1089446003973 Mg-chelatase subunit ChlI [Coenzyme metabolism]; Region: ChlI; COG1239 1089446003974 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1089446003975 Walker A motif; other site 1089446003976 ATP binding site [chemical binding]; other site 1089446003977 Walker B motif; other site 1089446003978 arginine finger; other site 1089446003979 malate:quinone oxidoreductase; Validated; Region: PRK05257 1089446003980 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 1089446003981 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 1089446003982 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1089446003983 mycothione reductase; Reviewed; Region: PRK07846 1089446003984 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1089446003985 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1089446003986 cobyric acid synthase; Provisional; Region: PRK00784 1089446003987 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1089446003988 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 1089446003989 catalytic triad [active] 1089446003990 methionine aminopeptidase; Provisional; Region: PRK12318 1089446003991 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 1089446003992 active site 1089446003993 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 1089446003994 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1089446003995 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 1089446003996 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 1089446003997 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 1089446003998 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 1089446003999 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 1089446004000 active site 1089446004001 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 1089446004002 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 1089446004003 putative substrate binding region [chemical binding]; other site 1089446004004 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 1089446004005 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 1089446004006 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 1089446004007 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 1089446004008 Protein of unknown function (DUF2631); Region: DUF2631; pfam10939 1089446004009 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14459 1089446004010 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1089446004011 FeS/SAM binding site; other site 1089446004012 Uncharacterized integral membrane protein [Function unknown]; Region: COG5416 1089446004013 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 1089446004014 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 1089446004015 ribosome recycling factor; Reviewed; Region: frr; PRK00083 1089446004016 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 1089446004017 hinge region; other site 1089446004018 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 1089446004019 putative nucleotide binding site [chemical binding]; other site 1089446004020 uridine monophosphate binding site [chemical binding]; other site 1089446004021 homohexameric interface [polypeptide binding]; other site 1089446004022 elongation factor Ts; Provisional; Region: tsf; PRK09377 1089446004023 UBA/TS-N domain; Region: UBA; pfam00627 1089446004024 Elongation factor TS; Region: EF_TS; pfam00889 1089446004025 Elongation factor TS; Region: EF_TS; pfam00889 1089446004026 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 1089446004027 rRNA interaction site [nucleotide binding]; other site 1089446004028 S8 interaction site; other site 1089446004029 putative laminin-1 binding site; other site 1089446004030 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1089446004031 Peptidase family M23; Region: Peptidase_M23; pfam01551 1089446004032 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 1089446004033 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1089446004034 active site 1089446004035 DNA binding site [nucleotide binding] 1089446004036 Int/Topo IB signature motif; other site 1089446004037 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 1089446004038 DNA protecting protein DprA; Region: dprA; TIGR00732 1089446004039 hypothetical protein; Reviewed; Region: PRK12497 1089446004040 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 1089446004041 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 1089446004042 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1089446004043 Walker A motif; other site 1089446004044 ATP binding site [chemical binding]; other site 1089446004045 Walker B motif; other site 1089446004046 arginine finger; other site 1089446004047 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 1089446004048 Protein of unknown function (DUF2469); Region: DUF2469; pfam10611 1089446004049 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 1089446004050 RNA/DNA hybrid binding site [nucleotide binding]; other site 1089446004051 active site 1089446004052 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 1089446004053 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 1089446004054 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 1089446004055 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 1089446004056 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1089446004057 RNA binding site [nucleotide binding]; other site 1089446004058 putative PTS system transporter subunits IIBC; Provisional; Region: PRK11404 1089446004059 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 1089446004060 active site 1089446004061 P-loop; other site 1089446004062 phosphorylation site [posttranslational modification] 1089446004063 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 1089446004064 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1089446004065 active site 1089446004066 phosphorylation site [posttranslational modification] 1089446004067 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 1089446004068 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 1089446004069 RimM N-terminal domain; Region: RimM; pfam01782 1089446004070 PRC-barrel domain; Region: PRC; pfam05239 1089446004071 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 1089446004072 30S ribosomal protein S16; Provisional; Region: rpsP; PRK14520 1089446004073 signal recognition particle protein; Provisional; Region: PRK10867 1089446004074 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 1089446004075 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 1089446004076 P loop; other site 1089446004077 GTP binding site [chemical binding]; other site 1089446004078 Signal peptide binding domain; Region: SRP_SPB; pfam02978 1089446004079 PII uridylyl-transferase; Provisional; Region: glnD; PRK00227 1089446004080 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 1089446004081 metal binding triad; other site 1089446004082 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 1089446004083 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1089446004084 Zn2+ binding site [ion binding]; other site 1089446004085 Mg2+ binding site [ion binding]; other site 1089446004086 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 1089446004087 Nitrogen regulatory protein P-II; Region: P-II; smart00938 1089446004088 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 1089446004089 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 1089446004090 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1089446004091 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 1089446004092 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 1089446004093 Walker A/P-loop; other site 1089446004094 ATP binding site [chemical binding]; other site 1089446004095 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; cl05797 1089446004096 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 1089446004097 ABC transporter signature motif; other site 1089446004098 Walker B; other site 1089446004099 D-loop; other site 1089446004100 H-loop/switch region; other site 1089446004101 Acylphosphatase; Region: Acylphosphatase; cl00551 1089446004102 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 1089446004103 amino acid carrier protein; Region: agcS; TIGR00835 1089446004104 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 1089446004105 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 1089446004106 DNA binding site [nucleotide binding] 1089446004107 catalytic residue [active] 1089446004108 H2TH interface [polypeptide binding]; other site 1089446004109 putative catalytic residues [active] 1089446004110 turnover-facilitating residue; other site 1089446004111 intercalation triad [nucleotide binding]; other site 1089446004112 8OG recognition residue [nucleotide binding]; other site 1089446004113 putative reading head residues; other site 1089446004114 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1089446004115 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1089446004116 ribonuclease III; Reviewed; Region: rnc; PRK00102 1089446004117 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 1089446004118 dimerization interface [polypeptide binding]; other site 1089446004119 active site 1089446004120 metal binding site [ion binding]; metal-binding site 1089446004121 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 1089446004122 dsRNA binding site [nucleotide binding]; other site 1089446004123 Predicted metal-binding, possibly nucleic acid-binding protein [General function prediction only]; Region: COG1399 1089446004124 Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599 1089446004125 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 1089446004126 RibD C-terminal domain; Region: RibD_C; cl17279 1089446004127 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 1089446004128 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 1089446004129 hexamer interface [polypeptide binding]; other site 1089446004130 ligand binding site [chemical binding]; other site 1089446004131 putative active site [active] 1089446004132 NAD(P) binding site [chemical binding]; other site 1089446004133 glutamate dehydrogenase; Provisional; Region: PRK09414 1089446004134 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 1089446004135 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 1089446004136 NAD(P) binding site [chemical binding]; other site 1089446004137 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 1089446004138 Galactose-1-phosphate uridylyltransferase [Energy production and conversion]; Region: GalT; COG1085 1089446004139 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 1089446004140 nucleotide binding site/active site [active] 1089446004141 HIT family signature motif; other site 1089446004142 catalytic residue [active] 1089446004143 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like6; cd05664 1089446004144 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1089446004145 metal binding site [ion binding]; metal-binding site 1089446004146 putative dimer interface [polypeptide binding]; other site 1089446004147 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 1089446004148 homodimer interface [polypeptide binding]; other site 1089446004149 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 1089446004150 active site pocket [active] 1089446004151 Electron transfer DM13; Region: DM13; pfam10517 1089446004152 pyruvate kinase; Provisional; Region: PRK06247 1089446004153 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 1089446004154 domain interfaces; other site 1089446004155 active site 1089446004156 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 1089446004157 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 1089446004158 active site 1089446004159 ribulose/triose binding site [chemical binding]; other site 1089446004160 phosphate binding site [ion binding]; other site 1089446004161 substrate (anthranilate) binding pocket [chemical binding]; other site 1089446004162 product (indole) binding pocket [chemical binding]; other site 1089446004163 Tryptophan-associated transmembrane protein (Trp_oprn_chp); Region: Trp_oprn_chp; pfam09534 1089446004164 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 1089446004165 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 1089446004166 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 1089446004167 substrate binding site [chemical binding]; other site 1089446004168 glutamase interaction surface [polypeptide binding]; other site 1089446004169 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 1089446004170 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1089446004171 active site 1089446004172 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 1089446004173 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 1089446004174 catalytic residues [active] 1089446004175 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146 1089446004176 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 1089446004177 putative active site [active] 1089446004178 oxyanion strand; other site 1089446004179 catalytic triad [active] 1089446004180 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1089446004181 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1089446004182 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 1089446004183 putative active site pocket [active] 1089446004184 4-fold oligomerization interface [polypeptide binding]; other site 1089446004185 metal binding residues [ion binding]; metal-binding site 1089446004186 3-fold/trimer interface [polypeptide binding]; other site 1089446004187 histidinol-phosphate aminotransferase; Provisional; Region: PRK03317 1089446004188 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1089446004189 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1089446004190 homodimer interface [polypeptide binding]; other site 1089446004191 catalytic residue [active] 1089446004192 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 1089446004193 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 1089446004194 NAD binding site [chemical binding]; other site 1089446004195 dimerization interface [polypeptide binding]; other site 1089446004196 product binding site; other site 1089446004197 substrate binding site [chemical binding]; other site 1089446004198 zinc binding site [ion binding]; other site 1089446004199 catalytic residues [active] 1089446004200 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 1089446004201 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 1089446004202 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1089446004203 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 1089446004204 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 1089446004205 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 1089446004206 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 1089446004207 active site 1089446004208 catalytic site [active] 1089446004209 DNA polymerase III subunit epsilon; Validated; Region: PRK06195 1089446004210 an uncharacterized bacterial subgroup of the DEDDh 3'-5' exonuclease domain family with similarity to the epsilon subunit of DNA polymerase III; Region: DNA_pol_III_epsilon_like; cd06130 1089446004211 active site 1089446004212 catalytic site [active] 1089446004213 substrate binding site [chemical binding]; other site 1089446004214 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 1089446004215 Dimer interface [polypeptide binding]; other site 1089446004216 BRCT sequence motif; other site 1089446004217 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1089446004218 synthetase active site [active] 1089446004219 NTP binding site [chemical binding]; other site 1089446004220 metal binding site [ion binding]; metal-binding site 1089446004221 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1089446004222 RNA binding surface [nucleotide binding]; other site 1089446004223 Uncharacterized conserved protein [Function unknown]; Region: COG1739 1089446004224 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 1089446004225 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 1089446004226 threonine dehydratase; Validated; Region: PRK08639 1089446004227 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 1089446004228 tetramer interface [polypeptide binding]; other site 1089446004229 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1089446004230 catalytic residue [active] 1089446004231 C-terminal regulatory domain of Threonine dehydratase; Region: Thr_dehydrat_C; pfam00585 1089446004232 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 1089446004233 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 1089446004234 active site 1089446004235 PHP Thumb interface [polypeptide binding]; other site 1089446004236 metal binding site [ion binding]; metal-binding site 1089446004237 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 1089446004238 generic binding surface I; other site 1089446004239 generic binding surface II; other site 1089446004240 Predicted permeases [General function prediction only]; Region: RarD; COG2962 1089446004241 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1089446004242 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 1089446004243 RNA binding surface [nucleotide binding]; other site 1089446004244 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1089446004245 active site 1089446004246 lipoprotein signal peptidase; Provisional; Region: PRK14764 1089446004247 lipoprotein signal peptidase; Provisional; Region: PRK14787 1089446004248 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 1089446004249 active site 1089446004250 homotetramer interface [polypeptide binding]; other site 1089446004251 homodimer interface [polypeptide binding]; other site 1089446004252 DNA polymerase IV; Provisional; Region: PRK03348 1089446004253 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 1089446004254 active site 1089446004255 DNA binding site [nucleotide binding] 1089446004256 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039 1089446004257 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 1089446004258 HIGH motif; other site 1089446004259 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 1089446004260 active site 1089446004261 KMSKS motif; other site 1089446004262 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 1089446004263 tRNA binding surface [nucleotide binding]; other site 1089446004264 anticodon binding site; other site 1089446004265 DivIVA protein; Region: DivIVA; pfam05103 1089446004266 DivIVA domain; Region: DivI1A_domain; TIGR03544 1089446004267 Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599 1089446004268 YGGT family; Region: YGGT; pfam02325 1089446004269 Protein of unknown function (DUF552); Region: DUF552; cl00775 1089446004270 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 1089446004271 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 1089446004272 Cell division GTPase [Cell division and chromosome partitioning]; Region: FtsZ; COG0206 1089446004273 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 1089446004274 nucleotide binding site [chemical binding]; other site 1089446004275 SulA interaction site; other site 1089446004276 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 1089446004277 Cell division protein FtsQ; Region: FtsQ; pfam03799 1089446004278 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 1089446004279 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1089446004280 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1089446004281 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1089446004282 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 1089446004283 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 1089446004284 homodimer interface [polypeptide binding]; other site 1089446004285 active site 1089446004286 cell division protein FtsW; Region: ftsW; TIGR02614 1089446004287 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK00141 1089446004288 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1089446004289 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 1089446004290 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 1089446004291 Mg++ binding site [ion binding]; other site 1089446004292 putative catalytic motif [active] 1089446004293 putative substrate binding site [chemical binding]; other site 1089446004294 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 1089446004295 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1089446004296 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1089446004297 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1089446004298 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 1089446004299 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1089446004300 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1089446004301 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1089446004302 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1089446004303 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1089446004304 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1089446004305 MraW methylase family; Region: Methyltransf_5; cl17771 1089446004306 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 1089446004307 cell division protein MraZ; Reviewed; Region: PRK00326 1089446004308 MraZ protein; Region: MraZ; pfam02381 1089446004309 MraZ protein; Region: MraZ; pfam02381 1089446004310 Protein of unknown function (DUF3040); Region: DUF3040; pfam11239 1089446004311 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1089446004312 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 1089446004313 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 1089446004314 FAD binding site [chemical binding]; other site 1089446004315 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1089446004316 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1089446004317 substrate binding pocket [chemical binding]; other site 1089446004318 chain length determination region; other site 1089446004319 substrate-Mg2+ binding site; other site 1089446004320 catalytic residues [active] 1089446004321 aspartate-rich region 1; other site 1089446004322 active site lid residues [active] 1089446004323 aspartate-rich region 2; other site 1089446004324 carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459 1089446004325 Class-II DAHP synthetase family; Region: DAHP_synth_2; pfam01474 1089446004326 Predicted membrane protein [Function unknown]; Region: COG4763 1089446004327 Acyltransferase family; Region: Acyl_transf_3; pfam01757 1089446004328 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1089446004329 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1089446004330 putative acyl-acceptor binding pocket; other site 1089446004331 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1089446004332 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1089446004333 nucleotide binding site [chemical binding]; other site 1089446004334 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1089446004335 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1089446004336 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1089446004337 NlpC/P60 family; Region: NLPC_P60; pfam00877 1089446004338 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1089446004339 NlpC/P60 family; Region: NLPC_P60; pfam00877 1089446004340 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 1089446004341 heme bH binding site [chemical binding]; other site 1089446004342 intrachain domain interface; other site 1089446004343 heme bL binding site [chemical binding]; other site 1089446004344 interchain domain interface [polypeptide binding]; other site 1089446004345 Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N_2; pfam13631 1089446004346 Qo binding site; other site 1089446004347 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 1089446004348 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 1089446004349 iron-sulfur cluster [ion binding]; other site 1089446004350 [2Fe-2S] cluster binding site [ion binding]; other site 1089446004351 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 1089446004352 Cytochrome c; Region: Cytochrom_C; pfam00034 1089446004353 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 1089446004354 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386 1089446004355 Subunit I/III interface [polypeptide binding]; other site 1089446004356 Cytochrome c oxidase subunit IV; Region: Cyt_c_ox_IV; pfam12270 1089446004357 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 1089446004358 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 1089446004359 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 1089446004360 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 1089446004361 active site 1089446004362 dimer interface [polypeptide binding]; other site 1089446004363 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 1089446004364 Ligand Binding Site [chemical binding]; other site 1089446004365 Molecular Tunnel; other site 1089446004366 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 1089446004367 Protein of unknown function (DUF3043); Region: DUF3043; pfam11241 1089446004368 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 1089446004369 homotrimer interface [polypeptide binding]; other site 1089446004370 Walker A motif; other site 1089446004371 GTP binding site [chemical binding]; other site 1089446004372 Walker B motif; other site 1089446004373 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 1089446004374 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 1089446004375 putative dimer interface [polypeptide binding]; other site 1089446004376 active site pocket [active] 1089446004377 putative cataytic base [active] 1089446004378 cobalamin synthase; Reviewed; Region: cobS; PRK00235 1089446004379 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 1089446004380 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 1089446004381 homodimer interface [polypeptide binding]; other site 1089446004382 substrate-cofactor binding pocket; other site 1089446004383 catalytic residue [active] 1089446004384 multifunctional aminopeptidase A; Provisional; Region: PRK00913 1089446004385 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 1089446004386 interface (dimer of trimers) [polypeptide binding]; other site 1089446004387 Substrate-binding/catalytic site; other site 1089446004388 Zn-binding sites [ion binding]; other site 1089446004389 pyruvate dehydrogenase dihydrolipoyltransacetylase; Validated; Region: aceF; PRK11854 1089446004390 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1089446004391 E3 interaction surface; other site 1089446004392 lipoyl attachment site [posttranslational modification]; other site 1089446004393 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1089446004394 E3 interaction surface; other site 1089446004395 lipoyl attachment site [posttranslational modification]; other site 1089446004396 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1089446004397 E3 interaction surface; other site 1089446004398 lipoyl attachment site [posttranslational modification]; other site 1089446004399 e3 binding domain; Region: E3_binding; pfam02817 1089446004400 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1089446004401 glycine dehydrogenase; Provisional; Region: PRK05367 1089446004402 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 1089446004403 tetramer interface [polypeptide binding]; other site 1089446004404 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1089446004405 catalytic residue [active] 1089446004406 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 1089446004407 tetramer interface [polypeptide binding]; other site 1089446004408 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1089446004409 catalytic residue [active] 1089446004410 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 1089446004411 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 1089446004412 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 1089446004413 lipoyl attachment site [posttranslational modification]; other site 1089446004414 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1089446004415 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1089446004416 active site 1089446004417 lipoate-protein ligase B; Provisional; Region: PRK14345 1089446004418 lipoyl synthase; Provisional; Region: PRK05481 1089446004419 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1089446004420 FeS/SAM binding site; other site 1089446004421 RDD family; Region: RDD; pfam06271 1089446004422 Protein of unknown function (DUF1049); Region: DUF1049; cl01539 1089446004423 Protein of unknown function (DUF2815); Region: DUF2815; pfam10991 1089446004424 Protein of unknown function (DUF2800); Region: DUF2800; pfam10926 1089446004425 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1089446004426 DNA binding residues [nucleotide binding] 1089446004427 Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443 1089446004428 Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189 1089446004429 DNA methylase; Region: N6_N4_Mtase; pfam01555 1089446004430 DNA methylase; Region: N6_N4_Mtase; cl17433 1089446004431 DNA helicase IV; Provisional; Region: helD; PRK11054 1089446004432 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 1089446004433 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 1089446004434 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 1089446004435 HsdM N-terminal domain; Region: HsdM_N; pfam12161 1089446004436 Htaa; Region: HtaA; pfam04213 1089446004437 Htaa; Region: HtaA; pfam04213 1089446004438 Predicted membrane protein, putative toxin regulator [General function prediction only]; Region: PfoR; COG3641 1089446004439 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 1089446004440 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK07807 1089446004441 IMP dehydrogenase/GMP reductase [Nucleotide transport and metabolism]; Region: GuaB; COG0516 1089446004442 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 1089446004443 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 1089446004444 active site 1089446004445 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3237 1089446004446 Predicted permease [General function prediction only]; Region: COG2056 1089446004447 Na+-H+ antiporter family; Region: Na_H_antiport_2; pfam13726 1089446004448 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_17; cd04676 1089446004449 nudix motif; other site 1089446004450 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 1089446004451 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 1089446004452 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1089446004453 catalytic residue [active] 1089446004454 Sortases are cysteine transpeptidases, found in gram-positive bacteria, that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase; cl09098 1089446004455 active site 1089446004456 catalytic site [active] 1089446004457 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cd00232 1089446004458 heme binding pocket [chemical binding]; other site 1089446004459 heme ligand [chemical binding]; other site 1089446004460 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 1089446004461 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 1089446004462 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1089446004463 CYTH-like (also known as triphosphate tunnel metalloenzyme (TTM)-like) Phosphatases; Region: CYTH-like_Pase; cd07374 1089446004464 putative active site; other site 1089446004465 putative metal binding residues [ion binding]; other site 1089446004466 signature motif; other site 1089446004467 putative triphosphate binding site [ion binding]; other site 1089446004468 CHAD domain; Region: CHAD; pfam05235 1089446004469 Galactokinase [Carbohydrate transport and metabolism]; Region: GalK; COG0153 1089446004470 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 1089446004471 RNB domain; Region: RNB; pfam00773 1089446004472 This domain is the catalytic domain of ribonuclease II; Region: RNB; smart00955 1089446004473 bifunctional RNase H/acid phosphatase; Provisional; Region: PRK07238 1089446004474 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 1089446004475 RNA/DNA hybrid binding site [nucleotide binding]; other site 1089446004476 active site 1089446004477 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1089446004478 catalytic core [active] 1089446004479 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 1089446004480 Putative zinc ribbon domain; Region: DUF164; pfam02591 1089446004481 Uncharacterized conserved protein [Function unknown]; Region: COG0327 1089446004482 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 1089446004483 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 1089446004484 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 1089446004485 hypothetical protein; Provisional; Region: PRK07908 1089446004486 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1089446004487 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1089446004488 homodimer interface [polypeptide binding]; other site 1089446004489 catalytic residue [active] 1089446004490 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 1089446004491 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1089446004492 motif II; other site 1089446004493 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 1089446004494 Low molecular weight phosphatase family; Region: LMWPc; cl00105 1089446004495 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 1089446004496 cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209 1089446004497 Protein of unknown function (DUF3052); Region: DUF3052; pfam11253 1089446004498 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 1089446004499 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 1089446004500 dimer interface [polypeptide binding]; other site 1089446004501 TPP-binding site [chemical binding]; other site 1089446004502 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1089446004503 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 1089446004504 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1089446004505 active site 1089446004506 motif I; other site 1089446004507 motif II; other site 1089446004508 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1089446004509 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1089446004510 Beta-lactamase; Region: Beta-lactamase; pfam00144 1089446004511 Predicted membrane protein [Function unknown]; Region: COG2860 1089446004512 UPF0126 domain; Region: UPF0126; pfam03458 1089446004513 UPF0126 domain; Region: UPF0126; pfam03458 1089446004514 DNA primase; Validated; Region: dnaG; PRK05667 1089446004515 CHC2 zinc finger; Region: zf-CHC2; pfam01807 1089446004516 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 1089446004517 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 1089446004518 active site 1089446004519 metal binding site [ion binding]; metal-binding site 1089446004520 interdomain interaction site; other site 1089446004521 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 1089446004522 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; smart00766 1089446004523 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 1089446004524 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 1089446004525 glutaminase active site [active] 1089446004526 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 1089446004527 dimer interface [polypeptide binding]; other site 1089446004528 active site 1089446004529 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 1089446004530 dimer interface [polypeptide binding]; other site 1089446004531 active site 1089446004532 RNase_Sa. Ribonucleases first isolated from Streptomyces aureofaciens. In general, ribonucleases cleave phosphodiester bonds in RNA and are essential for both non-specific RNA degradation and for numerous forms of RNA processing. RNAse Sa is a guanylate...; Region: RNase_Sa; cd00607 1089446004533 active site 1089446004534 barstar interaction site; other site 1089446004535 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK03007 1089446004536 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1089446004537 Zn2+ binding site [ion binding]; other site 1089446004538 Mg2+ binding site [ion binding]; other site 1089446004539 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 1089446004540 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 1089446004541 putative active site [active] 1089446004542 Repair protein; Region: Repair_PSII; pfam04536 1089446004543 glycyl-tRNA synthetase; Provisional; Region: PRK04173 1089446004544 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1089446004545 motif 1; other site 1089446004546 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 1089446004547 active site 1089446004548 motif 2; other site 1089446004549 motif 3; other site 1089446004550 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 1089446004551 anticodon binding site; other site 1089446004552 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1089446004553 putative DNA binding site [nucleotide binding]; other site 1089446004554 putative Zn2+ binding site [ion binding]; other site 1089446004555 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1089446004556 metal binding site 2 [ion binding]; metal-binding site 1089446004557 putative DNA binding helix; other site 1089446004558 metal binding site 1 [ion binding]; metal-binding site 1089446004559 dimer interface [polypeptide binding]; other site 1089446004560 structural Zn2+ binding site [ion binding]; other site 1089446004561 Ferritin-CCC1, N-terminal ferritin-like diiron-binding domain; Region: Ferritin_CCC1_N; cd01044 1089446004562 diiron binding motif [ion binding]; other site 1089446004563 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_2; cd02433 1089446004564 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 1089446004565 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 1089446004566 catalytic residue [active] 1089446004567 putative FPP diphosphate binding site; other site 1089446004568 putative FPP binding hydrophobic cleft; other site 1089446004569 dimer interface [polypeptide binding]; other site 1089446004570 putative IPP diphosphate binding site; other site 1089446004571 Recombination protein O N terminal; Region: RecO_N; pfam11967 1089446004572 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 1089446004573 Recombination protein O C terminal; Region: RecO_C; pfam02565 1089446004574 GTPase Era; Reviewed; Region: era; PRK00089 1089446004575 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 1089446004576 G1 box; other site 1089446004577 GTP/Mg2+ binding site [chemical binding]; other site 1089446004578 Switch I region; other site 1089446004579 G2 box; other site 1089446004580 Switch II region; other site 1089446004581 G3 box; other site 1089446004582 G4 box; other site 1089446004583 G5 box; other site 1089446004584 KH domain; Region: KH_2; pfam07650 1089446004585 pyridoxamine kinase; Validated; Region: PRK05756 1089446004586 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 1089446004587 dimer interface [polypeptide binding]; other site 1089446004588 pyridoxal binding site [chemical binding]; other site 1089446004589 ATP binding site [chemical binding]; other site 1089446004590 Domain of unknown function DUF21; Region: DUF21; pfam01595 1089446004591 FOG: CBS domain [General function prediction only]; Region: COG0517 1089446004592 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1089446004593 Transporter associated domain; Region: CorC_HlyC; smart01091 1089446004594 metal-binding heat shock protein; Provisional; Region: PRK00016 1089446004595 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 1089446004596 PhoH-like protein; Region: PhoH; pfam02562 1089446004597 RNA methyltransferase, RsmE family; Region: TIGR00046 1089446004598 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 1089446004599 chaperone protein DnaJ; Provisional; Region: PRK14278 1089446004600 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1089446004601 HSP70 interaction site [polypeptide binding]; other site 1089446004602 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 1089446004603 Zn binding sites [ion binding]; other site 1089446004604 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 1089446004605 dimer interface [polypeptide binding]; other site 1089446004606 coproporphyrinogen III oxidase; Validated; Region: PRK05628 1089446004607 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1089446004608 FeS/SAM binding site; other site 1089446004609 HemN C-terminal domain; Region: HemN_C; pfam06969 1089446004610 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 1089446004611 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 1089446004612 acyl-activating enzyme (AAE) consensus motif; other site 1089446004613 putative AMP binding site [chemical binding]; other site 1089446004614 putative active site [active] 1089446004615 putative CoA binding site [chemical binding]; other site 1089446004616 4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052 1089446004617 4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640 1089446004618 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 1089446004619 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 1089446004620 active site 1089446004621 Zn binding site [ion binding]; other site 1089446004622 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1089446004623 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 1089446004624 substrate binding pocket [chemical binding]; other site 1089446004625 catalytic triad [active] 1089446004626 Isopentenyldiphosphate isomerase [Lipid metabolism]; Region: Idi; COG1443 1089446004627 Isopentenyl diphosphate (IPP) isomerase, a member of the Nudix hydrolase superfamily, is a key enzyme in the isoprenoid biosynthetic pathway. Isoprenoids comprise a large family of natural products including sterols, carotenoids, dolichols and prenylated...; Region: IPP_Isomerase; cd02885 1089446004628 active site 1089446004629 metal binding site [ion binding]; metal-binding site 1089446004630 nudix motif; other site 1089446004631 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1089446004632 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1089446004633 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1089446004634 Walker A/P-loop; other site 1089446004635 ATP binding site [chemical binding]; other site 1089446004636 Q-loop/lid; other site 1089446004637 ABC transporter signature motif; other site 1089446004638 Walker B; other site 1089446004639 D-loop; other site 1089446004640 H-loop/switch region; other site 1089446004641 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 1089446004642 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 1089446004643 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1089446004644 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1089446004645 active site 1089446004646 BCCT family transporter; Region: BCCT; pfam02028 1089446004647 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 1089446004648 Predicted permeases [General function prediction only]; Region: COG0679 1089446004649 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1089446004650 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_6; cd08494 1089446004651 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1089446004652 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1089446004653 dimer interface [polypeptide binding]; other site 1089446004654 conserved gate region; other site 1089446004655 putative PBP binding loops; other site 1089446004656 ABC-ATPase subunit interface; other site 1089446004657 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 1089446004658 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1089446004659 dimer interface [polypeptide binding]; other site 1089446004660 conserved gate region; other site 1089446004661 putative PBP binding loops; other site 1089446004662 ABC-ATPase subunit interface; other site 1089446004663 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 1089446004664 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1089446004665 Walker A/P-loop; other site 1089446004666 ATP binding site [chemical binding]; other site 1089446004667 Q-loop/lid; other site 1089446004668 ABC transporter signature motif; other site 1089446004669 Walker B; other site 1089446004670 D-loop; other site 1089446004671 H-loop/switch region; other site 1089446004672 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1089446004673 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1089446004674 Walker A/P-loop; other site 1089446004675 ATP binding site [chemical binding]; other site 1089446004676 Q-loop/lid; other site 1089446004677 ABC transporter signature motif; other site 1089446004678 Walker B; other site 1089446004679 D-loop; other site 1089446004680 H-loop/switch region; other site 1089446004681 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1089446004682 proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249 1089446004683 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 1089446004684 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1089446004685 catalytic residue [active] 1089446004686 Sulphur transport; Region: Sulf_transp; pfam04143 1089446004687 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 1089446004688 CPxP motif; other site 1089446004689 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1089446004690 Binding-protein-dependent transport system inner membrane component; Region: BPD_transp_1; pfam00528 1089446004691 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1089446004692 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1089446004693 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1089446004694 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1089446004695 putative substrate translocation pore; other site 1089446004696 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1089446004697 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_3; cd08490 1089446004698 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1089446004699 thiamine ABC transporter, ATP-binding protein; Region: thiQ; TIGR01277 1089446004700 Walker A/P-loop; other site 1089446004701 ATP binding site [chemical binding]; other site 1089446004702 Q-loop/lid; other site 1089446004703 ABC transporter signature motif; other site 1089446004704 Walker B; other site 1089446004705 D-loop; other site 1089446004706 H-loop/switch region; other site 1089446004707 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1089446004708 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1089446004709 Walker A/P-loop; other site 1089446004710 ATP binding site [chemical binding]; other site 1089446004711 Q-loop/lid; other site 1089446004712 ABC transporter signature motif; other site 1089446004713 Walker B; other site 1089446004714 D-loop; other site 1089446004715 H-loop/switch region; other site 1089446004716 GTP-binding protein LepA; Provisional; Region: PRK05433 1089446004717 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 1089446004718 G1 box; other site 1089446004719 putative GEF interaction site [polypeptide binding]; other site 1089446004720 GTP/Mg2+ binding site [chemical binding]; other site 1089446004721 Switch I region; other site 1089446004722 G2 box; other site 1089446004723 G3 box; other site 1089446004724 Switch II region; other site 1089446004725 G4 box; other site 1089446004726 G5 box; other site 1089446004727 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 1089446004728 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 1089446004729 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 1089446004730 PemK-like protein; Region: PemK; pfam02452 1089446004731 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 1089446004732 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 1089446004733 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1089446004734 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1089446004735 hypothetical protein; Validated; Region: PRK05629 1089446004736 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 1089446004737 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 1089446004738 Competence protein; Region: Competence; pfam03772 1089446004739 comEA protein; Region: comE; TIGR01259 1089446004740 Uncharacterized protein conserved in bacteria [Function unknown]; Region: DegV; COG1307 1089446004741 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 1089446004742 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1089446004743 catalytic core [active] 1089446004744 Oligomerisation domain; Region: Oligomerisation; pfam02410 1089446004745 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 1089446004746 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 1089446004747 active site 1089446004748 (T/H)XGH motif; other site 1089446004749 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 1089446004750 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 1089446004751 putative catalytic cysteine [active] 1089446004752 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_2; cd12159 1089446004753 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 1089446004754 putative ligand binding site [chemical binding]; other site 1089446004755 putative NAD binding site [chemical binding]; other site 1089446004756 catalytic site [active] 1089446004757 Protein of unknown function (DUF454); Region: DUF454; cl01063 1089446004758 Predicted permease [General function prediction only]; Region: COG2985 1089446004759 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 1089446004760 TrkA-C domain; Region: TrkA_C; pfam02080 1089446004761 Predicted Permease Membrane Region; Region: Asp-Al_Ex; cl06061 1089446004762 GTPase CgtA; Reviewed; Region: obgE; PRK12296 1089446004763 GTP1/OBG; Region: GTP1_OBG; pfam01018 1089446004764 Obg GTPase; Region: Obg; cd01898 1089446004765 G1 box; other site 1089446004766 GTP/Mg2+ binding site [chemical binding]; other site 1089446004767 Switch I region; other site 1089446004768 G2 box; other site 1089446004769 G3 box; other site 1089446004770 Switch II region; other site 1089446004771 G4 box; other site 1089446004772 G5 box; other site 1089446004773 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 1089446004774 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 1089446004775 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 1089446004776 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 1089446004777 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1089446004778 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 1089446004779 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 1089446004780 homodimer interface [polypeptide binding]; other site 1089446004781 oligonucleotide binding site [chemical binding]; other site 1089446004782 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 1089446004783 active site 1089446004784 multimer interface [polypeptide binding]; other site 1089446004785 Predicted ornithine cyclodeaminase, mu-crystallin homolog [Amino acid transport and metabolism]; Region: COG2423 1089446004786 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 1089446004787 Protein of unknown function (DUF4233); Region: DUF4233; pfam14017 1089446004788 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 1089446004789 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1089446004790 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1089446004791 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1089446004792 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 1089446004793 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1089446004794 active site 1089446004795 HIGH motif; other site 1089446004796 nucleotide binding site [chemical binding]; other site 1089446004797 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1089446004798 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 1089446004799 active site 1089446004800 KMSKS motif; other site 1089446004801 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 1089446004802 tRNA binding surface [nucleotide binding]; other site 1089446004803 anticodon binding site; other site 1089446004804 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 1089446004805 Chloroplast-like malate dehydrogenases; Region: MDH_choloroplast_like; cd01338 1089446004806 malate dehydrogenase; Provisional; Region: PRK05442 1089446004807 NAD(P) binding site [chemical binding]; other site 1089446004808 dimer interface [polypeptide binding]; other site 1089446004809 malate binding site [chemical binding]; other site 1089446004810 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1089446004811 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1089446004812 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 1089446004813 ClpX C4-type zinc finger; Region: zf-C4_ClpX; smart00994 1089446004814 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 1089446004815 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1089446004816 Walker A motif; other site 1089446004817 ATP binding site [chemical binding]; other site 1089446004818 Walker B motif; other site 1089446004819 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1089446004820 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 1089446004821 Glutamine amidotransferase class-I; Region: GATase; pfam00117 1089446004822 glutamine binding [chemical binding]; other site 1089446004823 catalytic triad [active] 1089446004824 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 1089446004825 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1089446004826 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 1089446004827 Aminotransferase class IV; Region: Aminotran_4; pfam01063 1089446004828 substrate-cofactor binding pocket; other site 1089446004829 ATP-dependent Clp protease proteolytic subunit; Reviewed; Region: PRK12553 1089446004830 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 1089446004831 oligomer interface [polypeptide binding]; other site 1089446004832 active site residues [active] 1089446004833 Clp protease; Region: CLP_protease; pfam00574 1089446004834 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 1089446004835 oligomer interface [polypeptide binding]; other site 1089446004836 active site residues [active] 1089446004837 trigger factor; Provisional; Region: tig; PRK01490 1089446004838 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1089446004839 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 1089446004840 Pirin-related protein [General function prediction only]; Region: COG1741 1089446004841 Pirin; Region: Pirin; pfam02678 1089446004842 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 1089446004843 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 1089446004844 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 1089446004845 DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972 1089446004846 catalytic residues [active] 1089446004847 aminopeptidase N, Streptomyces lividans type; Region: pepN_strep_liv; TIGR02412 1089446004848 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_3; cd09602 1089446004849 Zn binding site [ion binding]; other site 1089446004850 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1089446004851 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1089446004852 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 1089446004853 apolar tunnel; other site 1089446004854 heme binding site [chemical binding]; other site 1089446004855 dimerization interface [polypeptide binding]; other site 1089446004856 Protein of unknown function, DUF606; Region: DUF606; pfam04657 1089446004857 Protein of unknown function, DUF606; Region: DUF606; pfam04657 1089446004858 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1089446004859 active site 1089446004860 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 1089446004861 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1089446004862 Walker A/P-loop; other site 1089446004863 ATP binding site [chemical binding]; other site 1089446004864 Q-loop/lid; other site 1089446004865 ABC transporter signature motif; other site 1089446004866 Walker B; other site 1089446004867 D-loop; other site 1089446004868 H-loop/switch region; other site 1089446004869 ABC transporter; Region: ABC_tran_2; pfam12848 1089446004870 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1089446004871 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1089446004872 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1089446004873 dimer interface [polypeptide binding]; other site 1089446004874 ssDNA binding site [nucleotide binding]; other site 1089446004875 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1089446004876 YcaO-like family; Region: YcaO; pfam02624 1089446004877 thiazole/oxazole-forming peptide maturase, SagD family component; Region: TOMM_cyclo_SagD; TIGR03604 1089446004878 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 1089446004879 FMN binding site [chemical binding]; other site 1089446004880 dimer interface [polypeptide binding]; other site 1089446004881 Nitroreductase family; Region: Nitroreductase; pfam00881 1089446004882 dimer interface [polypeptide binding]; other site 1089446004883 thiazole/oxazole-forming peptide maturase, SagD family component; Region: TOMM_cyclo_SagD; TIGR03604 1089446004884 YcaO-like family; Region: YcaO; pfam02624 1089446004885 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 1089446004886 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1089446004887 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1089446004888 Walker A/P-loop; other site 1089446004889 ATP binding site [chemical binding]; other site 1089446004890 Q-loop/lid; other site 1089446004891 ABC transporter signature motif; other site 1089446004892 Walker B; other site 1089446004893 D-loop; other site 1089446004894 H-loop/switch region; other site 1089446004895 Copper resistance protein D; Region: CopD; pfam05425 1089446004896 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; pfam09678 1089446004897 Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966 1089446004898 Carbon starvation protein CstA; Region: CstA; pfam02554 1089446004899 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 1089446004900 Protein of unknown function (DUF466); Region: DUF466; pfam04328 1089446004901 Peptidase S8 family domain, uncharacterized subfamily 13; Region: Peptidases_S8_13; cd07496 1089446004902 active site 1089446004903 catalytic triad [active] 1089446004904 Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288 1089446004905 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 1089446004906 NADP binding site [chemical binding]; other site 1089446004907 dimer interface [polypeptide binding]; other site 1089446004908 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 1089446004909 classical (c) SDRs; Region: SDR_c; cd05233 1089446004910 NAD(P) binding site [chemical binding]; other site 1089446004911 active site 1089446004912 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 1089446004913 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 1089446004914 catalytic site [active] 1089446004915 putative active site [active] 1089446004916 putative substrate binding site [chemical binding]; other site 1089446004917 dimer interface [polypeptide binding]; other site 1089446004918 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 1089446004919 N-acetylneuraminate lyase; Provisional; Region: PRK04147 1089446004920 inhibitor site; inhibition site 1089446004921 active site 1089446004922 dimer interface [polypeptide binding]; other site 1089446004923 catalytic residue [active] 1089446004924 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like; cl17506 1089446004925 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 1089446004926 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432 1089446004927 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1089446004928 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 1089446004929 Prostaglandin dehydrogenases; Region: PGDH; cd05288 1089446004930 NAD(P) binding site [chemical binding]; other site 1089446004931 substrate binding site [chemical binding]; other site 1089446004932 dimer interface [polypeptide binding]; other site 1089446004933 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 1089446004934 Isochorismatase family; Region: Isochorismatase; pfam00857 1089446004935 catalytic triad [active] 1089446004936 metal binding site [ion binding]; metal-binding site 1089446004937 conserved cis-peptide bond; other site 1089446004938 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 1089446004939 Protein of unknown function (DUF3618); Region: DUF3618; pfam12277 1089446004940 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 1089446004941 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 1089446004942 catalytic triad [active] 1089446004943 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1089446004944 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1089446004945 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 1089446004946 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 1089446004947 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1089446004948 Enoyl reductase domain of yeast-type FAS1 [Lipid metabolism]; Region: COG4981 1089446004949 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1089446004950 phosphate binding site [ion binding]; other site 1089446004951 Domain of unknown function (DUF1729); Region: DUF1729; pfam08354 1089446004952 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1089446004953 active site 2 [active] 1089446004954 active site 1 [active] 1089446004955 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 1089446004956 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1089446004957 3-oxoacyl-[acyl-carrier protein]; Region: COG4982 1089446004958 ketoacyl reductase (KR) domain of fungal-type fatty acid synthase (fFAS), classical (c)-like SDRs; Region: KR_fFAS_SDR_c_like; cd08950 1089446004959 putative NAD(P) binding site [chemical binding]; other site 1089446004960 active site 1089446004961 "elongating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type I and II and polyketide synthases.They are characterized by the utlization of acyl carrier protein (ACP)...; Region: elong_cond_enzymes; cd00828 1089446004962 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 1089446004963 active site 1089446004964 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1089446004965 Histidine kinase; Region: HisKA_3; pfam07730 1089446004966 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 1089446004967 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1089446004968 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1089446004969 active site 1089446004970 phosphorylation site [posttranslational modification] 1089446004971 intermolecular recognition site; other site 1089446004972 dimerization interface [polypeptide binding]; other site 1089446004973 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1089446004974 DNA binding residues [nucleotide binding] 1089446004975 dimerization interface [polypeptide binding]; other site 1089446004976 Protein of unknown function (DUF418); Region: DUF418; pfam04235 1089446004977 CAAX protease self-immunity; Region: Abi; pfam02517 1089446004978 Glucitol operon activator protein (GutM); Region: GutM; cl01890 1089446004979 Domain of unknown function (DUF3817); Region: DUF3817; pfam12823 1089446004980 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 1089446004981 active site 1089446004982 dimerization interface [polypeptide binding]; other site 1089446004983 ribonuclease PH; Reviewed; Region: rph; PRK00173 1089446004984 Ribonuclease PH; Region: RNase_PH_bact; cd11362 1089446004985 hexamer interface [polypeptide binding]; other site 1089446004986 active site 1089446004987 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 1089446004988 glutamate racemase; Provisional; Region: PRK00865 1089446004989 Rhomboid family; Region: Rhomboid; cl11446 1089446004990 Domain of unknown function (DUF2017); Region: DUF2017; pfam09438 1089446004991 ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033 1089446004992 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 1089446004993 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 1089446004994 active site 1089446004995 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 1089446004996 DEAD/DEAH box helicase; Region: DEAD; pfam00270 1089446004997 ATP binding site [chemical binding]; other site 1089446004998 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1089446004999 putative Mg++ binding site [ion binding]; other site 1089446005000 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 1089446005001 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1089446005002 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1089446005003 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 1089446005004 ACT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_2; cd04871 1089446005005 phosphoserine phosphatase SerB; Region: serB; TIGR00338 1089446005006 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1089446005007 motif II; other site 1089446005008 Winged helix-turn helix; Region: HTH_29; pfam13551 1089446005009 Helix-turn-helix domain; Region: HTH_28; pfam13518 1089446005010 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 1089446005011 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 1089446005012 D-pathway; other site 1089446005013 Putative ubiquinol binding site [chemical binding]; other site 1089446005014 Low-spin heme (heme b) binding site [chemical binding]; other site 1089446005015 Putative water exit pathway; other site 1089446005016 Binuclear center (heme o3/CuB) [ion binding]; other site 1089446005017 K-pathway; other site 1089446005018 Putative proton exit pathway; other site 1089446005019 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 1089446005020 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 1089446005021 dimer interface [polypeptide binding]; other site 1089446005022 putative radical transfer pathway; other site 1089446005023 diiron center [ion binding]; other site 1089446005024 tyrosyl radical; other site 1089446005025 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 1089446005026 Ferritin-like domain; Region: Ferritin; pfam00210 1089446005027 ferroxidase diiron center [ion binding]; other site 1089446005028 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08188 1089446005029 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 1089446005030 Class I ribonucleotide reductase; Region: RNR_I; cd01679 1089446005031 active site 1089446005032 dimer interface [polypeptide binding]; other site 1089446005033 catalytic residues [active] 1089446005034 effector binding site; other site 1089446005035 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 1089446005036 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 1089446005037 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 1089446005038 catalytic residues [active] 1089446005039 50S ribosomal protein L36; Validated; Region: rpmJ; PRK00831 1089446005040 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 1089446005041 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 1089446005042 homodimer interface [polypeptide binding]; other site 1089446005043 NAD binding pocket [chemical binding]; other site 1089446005044 ATP binding pocket [chemical binding]; other site 1089446005045 Mg binding site [ion binding]; other site 1089446005046 active-site loop [active] 1089446005047 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900 1089446005048 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1089446005049 dimerization interface [polypeptide binding]; other site 1089446005050 putative DNA binding site [nucleotide binding]; other site 1089446005051 putative Zn2+ binding site [ion binding]; other site 1089446005052 Protein of unknown function (DUF4065); Region: DUF4065; cl01445 1089446005053 Thioredoxin; Region: Thioredoxin_4; cl17273 1089446005054 phosphoglucomutase; Validated; Region: PRK07564 1089446005055 This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801 1089446005056 active site 1089446005057 substrate binding site [chemical binding]; other site 1089446005058 metal binding site [ion binding]; metal-binding site 1089446005059 camphor resistance protein CrcB; Provisional; Region: ccrB; PRK00134 1089446005060 CrcB-like protein; Region: CRCB; pfam02537 1089446005061 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1089446005062 FtsX-like permease family; Region: FtsX; pfam02687 1089446005063 FtsX-like permease family; Region: FtsX; pfam02687 1089446005064 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1089446005065 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1089446005066 Walker A/P-loop; other site 1089446005067 ATP binding site [chemical binding]; other site 1089446005068 Q-loop/lid; other site 1089446005069 ABC transporter signature motif; other site 1089446005070 Walker B; other site 1089446005071 D-loop; other site 1089446005072 H-loop/switch region; other site 1089446005073 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 1089446005074 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 1089446005075 hinge; other site 1089446005076 active site 1089446005077 cob(I)alamin adenosyltransferase [Coenzyme transport and metabolism]; Region: COG2096 1089446005078 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1089446005079 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1089446005080 DNA binding residues [nucleotide binding] 1089446005081 dimerization interface [polypeptide binding]; other site 1089446005082 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1089446005083 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1089446005084 dimer interface [polypeptide binding]; other site 1089446005085 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1089446005086 catalytic residue [active] 1089446005087 serine O-acetyltransferase; Region: cysE; TIGR01172 1089446005088 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 1089446005089 trimer interface [polypeptide binding]; other site 1089446005090 active site 1089446005091 substrate binding site [chemical binding]; other site 1089446005092 CoA binding site [chemical binding]; other site 1089446005093 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1089446005094 Coenzyme A binding pocket [chemical binding]; other site 1089446005095 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 1089446005096 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 1089446005097 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 1089446005098 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1089446005099 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 1089446005100 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1089446005101 Walker A/P-loop; other site 1089446005102 ATP binding site [chemical binding]; other site 1089446005103 Q-loop/lid; other site 1089446005104 ABC transporter signature motif; other site 1089446005105 Walker B; other site 1089446005106 D-loop; other site 1089446005107 H-loop/switch region; other site 1089446005108 thiol reductant ABC exporter, CydC subunit; Region: CydC; TIGR02868 1089446005109 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1089446005110 Walker A/P-loop; other site 1089446005111 ATP binding site [chemical binding]; other site 1089446005112 Q-loop/lid; other site 1089446005113 ABC transporter signature motif; other site 1089446005114 Walker B; other site 1089446005115 D-loop; other site 1089446005116 H-loop/switch region; other site 1089446005117 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 1089446005118 succinate CoA transferase; Region: YgfH_subfam; TIGR03458 1089446005119 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 1089446005120 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 1089446005121 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 1089446005122 FMN binding site [chemical binding]; other site 1089446005123 active site 1089446005124 catalytic residues [active] 1089446005125 substrate binding site [chemical binding]; other site 1089446005126 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 1089446005127 PhoU domain; Region: PhoU; pfam01895 1089446005128 phosphate transporter ATP-binding protein; Provisional; Region: PRK14241 1089446005129 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 1089446005130 Walker A/P-loop; other site 1089446005131 ATP binding site [chemical binding]; other site 1089446005132 Q-loop/lid; other site 1089446005133 ABC transporter signature motif; other site 1089446005134 Walker B; other site 1089446005135 D-loop; other site 1089446005136 H-loop/switch region; other site 1089446005137 phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974 1089446005138 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1089446005139 dimer interface [polypeptide binding]; other site 1089446005140 conserved gate region; other site 1089446005141 putative PBP binding loops; other site 1089446005142 ABC-ATPase subunit interface; other site 1089446005143 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 1089446005144 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1089446005145 dimer interface [polypeptide binding]; other site 1089446005146 conserved gate region; other site 1089446005147 putative PBP binding loops; other site 1089446005148 ABC-ATPase subunit interface; other site 1089446005149 PBP superfamily domain; Region: PBP_like_2; cl17296 1089446005150 mycothiol synthase; Region: mycothiol_MshD; TIGR03448 1089446005151 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1089446005152 Coenzyme A binding pocket [chemical binding]; other site 1089446005153 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1089446005154 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 1089446005155 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 1089446005156 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 1089446005157 nitrobindin heme-binding domain; Region: nitrobindin; cd07828 1089446005158 heme-binding site [chemical binding]; other site 1089446005159 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 1089446005160 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 1089446005161 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1089446005162 catalytic residue [active] 1089446005163 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 1089446005164 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 1089446005165 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 1089446005166 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 1089446005167 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 1089446005168 dimerization interface [polypeptide binding]; other site 1089446005169 putative ATP binding site [chemical binding]; other site 1089446005170 amidophosphoribosyltransferase; Provisional; Region: PRK07847 1089446005171 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 1089446005172 active site 1089446005173 tetramer interface [polypeptide binding]; other site 1089446005174 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1089446005175 active site 1089446005176 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 1089446005177 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 1089446005178 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 1089446005179 dimer interface [polypeptide binding]; other site 1089446005180 putative radical transfer pathway; other site 1089446005181 diiron center [ion binding]; other site 1089446005182 tyrosyl radical; other site 1089446005183 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 1089446005184 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 1089446005185 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 1089446005186 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 1089446005187 dimerization interface [polypeptide binding]; other site 1089446005188 ATP binding site [chemical binding]; other site 1089446005189 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 1089446005190 dimerization interface [polypeptide binding]; other site 1089446005191 ATP binding site [chemical binding]; other site 1089446005192 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 1089446005193 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 1089446005194 putative active site [active] 1089446005195 catalytic triad [active] 1089446005196 phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974 1089446005197 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 1089446005198 catalytic residues [active] 1089446005199 dimer interface [polypeptide binding]; other site 1089446005200 Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770 1089446005201 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1089446005202 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 1089446005203 ATP binding site [chemical binding]; other site 1089446005204 active site 1089446005205 substrate binding site [chemical binding]; other site 1089446005206 adenylosuccinate lyase; Region: purB; TIGR00928 1089446005207 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 1089446005208 tetramer interface [polypeptide binding]; other site 1089446005209 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 1089446005210 TrkA-N domain; Region: TrkA_N; pfam02254 1089446005211 TrkA-C domain; Region: TrkA_C; pfam02080 1089446005212 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 1089446005213 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 1089446005214 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 1089446005215 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 1089446005216 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 1089446005217 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 1089446005218 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 1089446005219 nucleotide binding site/active site [active] 1089446005220 HIT family signature motif; other site 1089446005221 catalytic residue [active] 1089446005222 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1089446005223 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1089446005224 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1089446005225 dimerization interface [polypeptide binding]; other site 1089446005226 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1089446005227 dimer interface [polypeptide binding]; other site 1089446005228 phosphorylation site [posttranslational modification] 1089446005229 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1089446005230 ATP binding site [chemical binding]; other site 1089446005231 Mg2+ binding site [ion binding]; other site 1089446005232 G-X-G motif; other site 1089446005233 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1089446005234 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1089446005235 active site 1089446005236 phosphorylation site [posttranslational modification] 1089446005237 intermolecular recognition site; other site 1089446005238 dimerization interface [polypeptide binding]; other site 1089446005239 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1089446005240 DNA binding site [nucleotide binding] 1089446005241 methyl viologen resistance protein SmvA; Provisional; Region: PRK14995 1089446005242 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1089446005243 putative substrate translocation pore; other site 1089446005244 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1089446005245 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1089446005246 Predicted esterase [General function prediction only]; Region: COG0627 1089446005247 S-formylglutathione hydrolase; Region: PLN02442 1089446005248 xanthine permease; Region: pbuX; TIGR03173 1089446005249 OHCU decarboxylase; Region: OHCU_decarbox; cl01251 1089446005250 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 1089446005251 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 1089446005252 putative active site [active] 1089446005253 pyruvate dehydrogenase; Provisional; Region: PRK06546 1089446005254 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 1089446005255 PYR/PP interface [polypeptide binding]; other site 1089446005256 tetramer interface [polypeptide binding]; other site 1089446005257 dimer interface [polypeptide binding]; other site 1089446005258 TPP binding site [chemical binding]; other site 1089446005259 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1089446005260 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 1089446005261 TPP-binding site [chemical binding]; other site 1089446005262 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 1089446005263 Uncharacterized conserved protein [Function unknown]; Region: COG3610 1089446005264 Uncharacterized conserved protein [Function unknown]; Region: COG2966 1089446005265 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 1089446005266 Protein of unknown function (DUF3815); Region: DUF3815; cl01118 1089446005267 Trehalose-6-phosphate synthase [Carbohydrate transport and metabolism]; Region: OtsA; COG0380 1089446005268 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 1089446005269 active site 1089446005270 homotetramer interface [polypeptide binding]; other site 1089446005271 Trehalose-6-phosphatase [Carbohydrate transport and metabolism]; Region: OtsB; COG1877 1089446005272 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105 1089446005273 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1089446005274 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1089446005275 DNA binding site [nucleotide binding] 1089446005276 domain linker motif; other site 1089446005277 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_3; cd06279 1089446005278 putative dimerization interface [polypeptide binding]; other site 1089446005279 putative ligand binding site [chemical binding]; other site 1089446005280 Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509 1089446005281 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 1089446005282 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 1089446005283 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1089446005284 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 1089446005285 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1089446005286 active site 1089446005287 HIGH motif; other site 1089446005288 nucleotide binding site [chemical binding]; other site 1089446005289 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1089446005290 KMSKS motif; other site 1089446005291 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 1089446005292 tRNA binding surface [nucleotide binding]; other site 1089446005293 anticodon binding site; other site 1089446005294 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 1089446005295 homotrimer interaction site [polypeptide binding]; other site 1089446005296 zinc binding site [ion binding]; other site 1089446005297 CDP-binding sites; other site 1089446005298 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 1089446005299 substrate binding site; other site 1089446005300 dimer interface; other site 1089446005301 Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329 1089446005302 DNA repair protein RadA; Provisional; Region: PRK11823 1089446005303 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1089446005304 Walker A motif; other site 1089446005305 ATP binding site [chemical binding]; other site 1089446005306 Walker B motif; other site 1089446005307 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 1089446005308 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA; cl00391 1089446005309 active site clefts [active] 1089446005310 zinc binding site [ion binding]; other site 1089446005311 dimer interface [polypeptide binding]; other site 1089446005312 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1089446005313 endonuclease III; Region: ENDO3c; smart00478 1089446005314 minor groove reading motif; other site 1089446005315 helix-hairpin-helix signature motif; other site 1089446005316 substrate binding pocket [chemical binding]; other site 1089446005317 active site 1089446005318 Uncharacterized conserved protein [Function unknown]; Region: COG2966 1089446005319 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 1089446005320 Protein of unknown function (DUF3815); Region: DUF3815; pfam12821 1089446005321 Protein of unknown function (DUF4236); Region: DUF4236; pfam14020 1089446005322 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 1089446005323 Clp amino terminal domain; Region: Clp_N; pfam02861 1089446005324 Clp amino terminal domain; Region: Clp_N; pfam02861 1089446005325 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1089446005326 Walker A motif; other site 1089446005327 ATP binding site [chemical binding]; other site 1089446005328 Walker B motif; other site 1089446005329 arginine finger; other site 1089446005330 UvrB/uvrC motif; Region: UVR; pfam02151 1089446005331 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1089446005332 Walker A motif; other site 1089446005333 ATP binding site [chemical binding]; other site 1089446005334 Walker B motif; other site 1089446005335 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1089446005336 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1089446005337 putative substrate translocation pore; other site 1089446005338 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 1089446005339 active site 1089446005340 tetramer interface [polypeptide binding]; other site 1089446005341 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 1089446005342 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1089446005343 CAAX protease self-immunity; Region: Abi; pfam02517 1089446005344 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 1089446005345 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 1089446005346 dimer interface [polypeptide binding]; other site 1089446005347 putative anticodon binding site; other site 1089446005348 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1089446005349 motif 1; other site 1089446005350 dimer interface [polypeptide binding]; other site 1089446005351 active site 1089446005352 motif 2; other site 1089446005353 motif 3; other site 1089446005354 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 1089446005355 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_2; cd03402 1089446005356 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4877 1089446005357 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1089446005358 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 1089446005359 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1089446005360 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1089446005361 NAD(P) binding site [chemical binding]; other site 1089446005362 catalytic residues [active] 1089446005363 BCCT family transporter; Region: BCCT; cl00569 1089446005364 choline dehydrogenase; Validated; Region: PRK02106 1089446005365 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1089446005366 pantoate--beta-alanine ligase; Region: panC; TIGR00018 1089446005367 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1089446005368 active site 1089446005369 nucleotide binding site [chemical binding]; other site 1089446005370 HIGH motif; other site 1089446005371 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1089446005372 KMSKS motif; other site 1089446005373 Protein of unknown function (DUF3180); Region: DUF3180; pfam11377 1089446005374 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 1089446005375 catalytic center binding site [active] 1089446005376 ATP binding site [chemical binding]; other site 1089446005377 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 1089446005378 homooctamer interface [polypeptide binding]; other site 1089446005379 active site 1089446005380 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 1089446005381 dihydropteroate synthase; Region: DHPS; TIGR01496 1089446005382 substrate binding pocket [chemical binding]; other site 1089446005383 dimer interface [polypeptide binding]; other site 1089446005384 inhibitor binding site; inhibition site 1089446005385 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 1089446005386 GTP cyclohydrolase I; Provisional; Region: PLN03044 1089446005387 homodecamer interface [polypeptide binding]; other site 1089446005388 active site 1089446005389 putative catalytic site residues [active] 1089446005390 zinc binding site [ion binding]; other site 1089446005391 GTP-CH-I/GFRP interaction surface; other site 1089446005392 FtsH Extracellular; Region: FtsH_ext; pfam06480 1089446005393 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 1089446005394 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1089446005395 Walker A motif; other site 1089446005396 ATP binding site [chemical binding]; other site 1089446005397 Walker B motif; other site 1089446005398 arginine finger; other site 1089446005399 Peptidase family M41; Region: Peptidase_M41; pfam01434 1089446005400 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1089446005401 active site 1089446005402 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 1089446005403 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 1089446005404 Ligand Binding Site [chemical binding]; other site 1089446005405 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 1089446005406 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 1089446005407 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 1089446005408 dimer interface [polypeptide binding]; other site 1089446005409 substrate binding site [chemical binding]; other site 1089446005410 metal binding sites [ion binding]; metal-binding site 1089446005411 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1089446005412 active site residue [active] 1089446005413 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1089446005414 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 1089446005415 Secretory lipase; Region: LIP; pfam03583 1089446005416 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1089446005417 MarR family; Region: MarR_2; pfam12802 1089446005418 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1089446005419 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1089446005420 acyl-activating enzyme (AAE) consensus motif; other site 1089446005421 AMP binding site [chemical binding]; other site 1089446005422 active site 1089446005423 CoA binding site [chemical binding]; other site 1089446005424 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1089446005425 non-ribosomal peptide synthetase terminal domain of unknown function; Region: NRPS_term_dom; TIGR02353 1089446005426 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1089446005427 putative trimer interface [polypeptide binding]; other site 1089446005428 putative CoA binding site [chemical binding]; other site 1089446005429 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1089446005430 putative trimer interface [polypeptide binding]; other site 1089446005431 putative CoA binding site [chemical binding]; other site 1089446005432 polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707 1089446005433 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 1089446005434 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 1089446005435 ring oligomerisation interface [polypeptide binding]; other site 1089446005436 ATP/Mg binding site [chemical binding]; other site 1089446005437 stacking interactions; other site 1089446005438 hinge regions; other site 1089446005439 hypothetical protein; Provisional; Region: PRK07907 1089446005440 M20 Dipeptidases; Region: M20_Dipept_like; cd03893 1089446005441 active site 1089446005442 metal binding site [ion binding]; metal-binding site 1089446005443 dimer interface [polypeptide binding]; other site 1089446005444 putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12644 1089446005445 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1089446005446 Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111 1089446005447 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 1089446005448 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 1089446005449 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK07946 1089446005450 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12665 1089446005451 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1089446005452 putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK08965 1089446005453 putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK07948 1089446005454 putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12592 1089446005455 Protein of unknown function (DUF2029); Region: DUF2029; cl09812 1089446005456 carboxylate-amine ligase; Provisional; Region: PRK13517 1089446005457 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 1089446005458 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 1089446005459 Protein of unknown function (DUF3263); Region: DUF3263; pfam11662 1089446005460 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 1089446005461 active site 1089446005462 catalytic residues [active] 1089446005463 metal binding site [ion binding]; metal-binding site 1089446005464 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1089446005465 Coenzyme A binding pocket [chemical binding]; other site 1089446005466 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 1089446005467 putative catalytic site [active] 1089446005468 putative phosphate binding site [ion binding]; other site 1089446005469 active site 1089446005470 metal binding site A [ion binding]; metal-binding site 1089446005471 DNA binding site [nucleotide binding] 1089446005472 putative AP binding site [nucleotide binding]; other site 1089446005473 putative metal binding site B [ion binding]; other site 1089446005474 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 1089446005475 Catalytic domain, repeat 1, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_1; cd09152 1089446005476 putative active site [active] 1089446005477 catalytic site [active] 1089446005478 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 1089446005479 putative active site [active] 1089446005480 catalytic site [active] 1089446005481 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 1089446005482 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1089446005483 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 1089446005484 Walker A/P-loop; other site 1089446005485 ATP binding site [chemical binding]; other site 1089446005486 Q-loop/lid; other site 1089446005487 ABC transporter signature motif; other site 1089446005488 Walker B; other site 1089446005489 D-loop; other site 1089446005490 H-loop/switch region; other site 1089446005491 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 1089446005492 nudix motif; other site 1089446005493 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 1089446005494 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1089446005495 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1089446005496 substrate binding pocket [chemical binding]; other site 1089446005497 membrane-bound complex binding site; other site 1089446005498 hinge residues; other site 1089446005499 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1089446005500 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1089446005501 active site 1089446005502 ATP binding site [chemical binding]; other site 1089446005503 substrate binding site [chemical binding]; other site 1089446005504 activation loop (A-loop); other site 1089446005505 propionate/acetate kinase; Provisional; Region: PRK12379 1089446005506 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 1089446005507 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 1089446005508 ferredoxin-NADP+ reductase; Region: PLN02852 1089446005509 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1089446005510 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1089446005511 Coenzyme A binding pocket [chemical binding]; other site 1089446005512 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1089446005513 active site 1089446005514 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 1089446005515 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1089446005516 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1089446005517 active site 1089446005518 Disulfide bond formation protein DsbB; Region: DsbB; pfam02600 1089446005519 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 1089446005520 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1089446005521 catalytic residues [active] 1089446005522 cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144 1089446005523 ResB-like family; Region: ResB; pfam05140 1089446005524 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125 1089446005525 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1089446005526 TPR motif; other site 1089446005527 TPR repeat; Region: TPR_11; pfam13414 1089446005528 binding surface 1089446005529 Cytochrome c552; Region: Cytochrom_C552; pfam02335 1089446005530 cytochrome c-type protein NapC; Provisional; Region: PRK10617; cl17554 1089446005531 cytochrome c nitrate reductase, small subunit; Region: cytochr_NrfH; TIGR03153 1089446005532 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 1089446005533 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 1089446005534 GDP-binding site [chemical binding]; other site 1089446005535 ACT binding site; other site 1089446005536 IMP binding site; other site 1089446005537 Predicted membrane protein [Function unknown]; Region: COG4129 1089446005538 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 1089446005539 Predicted membrane protein [Function unknown]; Region: COG4129 1089446005540 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 1089446005541 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 1089446005542 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1089446005543 Walker A/P-loop; other site 1089446005544 ATP binding site [chemical binding]; other site 1089446005545 Q-loop/lid; other site 1089446005546 ABC transporter signature motif; other site 1089446005547 Walker B; other site 1089446005548 D-loop; other site 1089446005549 H-loop/switch region; other site 1089446005550 Predicted transcriptional regulators [Transcription]; Region: COG1695 1089446005551 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 1089446005552 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 1089446005553 Cna protein B-type domain; Region: Cna_B; pfam05738 1089446005554 CshA-type fibril repeat; Region: CshA_fibril_rpt; TIGR04225 1089446005555 CshA-type fibril repeat; Region: CshA_fibril_rpt; TIGR04225 1089446005556 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 1089446005557 Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cl17181 1089446005558 active site 1089446005559 intersubunit interface [polypeptide binding]; other site 1089446005560 zinc binding site [ion binding]; other site 1089446005561 Na+ binding site [ion binding]; other site 1089446005562 Glycosyl hydrolase family 76; Region: Glyco_hydro_76; cl01996 1089446005563 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 1089446005564 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1089446005565 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1089446005566 active site 1089446005567 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 1089446005568 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 1089446005569 active site residue [active] 1089446005570 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 1089446005571 active site residue [active] 1089446005572 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 1089446005573 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 1089446005574 Gram positive anchor; Region: Gram_pos_anchor; cl15427 1089446005575 Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827 1089446005576 active site 1089446005577 catalytic site [active] 1089446005578 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 1089446005579 Cna protein B-type domain; Region: Cna_B; pfam05738 1089446005580 Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827 1089446005581 active site 1089446005582 catalytic site [active] 1089446005583 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 1089446005584 Clp amino terminal domain; Region: Clp_N; pfam02861 1089446005585 Clp amino terminal domain; Region: Clp_N; pfam02861 1089446005586 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1089446005587 Walker A motif; other site 1089446005588 ATP binding site [chemical binding]; other site 1089446005589 Walker B motif; other site 1089446005590 arginine finger; other site 1089446005591 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1089446005592 Walker A motif; other site 1089446005593 ATP binding site [chemical binding]; other site 1089446005594 Walker B motif; other site 1089446005595 arginine finger; other site 1089446005596 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1089446005597 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 1089446005598 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1089446005599 Walker A/P-loop; other site 1089446005600 ATP binding site [chemical binding]; other site 1089446005601 Q-loop/lid; other site 1089446005602 ABC transporter signature motif; other site 1089446005603 Walker B; other site 1089446005604 D-loop; other site 1089446005605 H-loop/switch region; other site 1089446005606 SH3 domain protein; Region: SH3_and_anchor; TIGR04211 1089446005607 Na+/glutamate symporter [Amino acid transport and metabolism]; Region: GltS; COG0786 1089446005608 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 1089446005609 FAD binding pocket [chemical binding]; other site 1089446005610 conserved FAD binding motif [chemical binding]; other site 1089446005611 phosphate binding motif [ion binding]; other site 1089446005612 beta-alpha-beta structure motif; other site 1089446005613 NAD binding pocket [chemical binding]; other site 1089446005614 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 1089446005615 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1089446005616 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1089446005617 FtsX-like permease family; Region: FtsX; pfam02687 1089446005618 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1089446005619 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1089446005620 Walker A/P-loop; other site 1089446005621 ATP binding site [chemical binding]; other site 1089446005622 Q-loop/lid; other site 1089446005623 ABC transporter signature motif; other site 1089446005624 Walker B; other site 1089446005625 D-loop; other site 1089446005626 H-loop/switch region; other site 1089446005627 HlyD family secretion protein; Region: HlyD_3; pfam13437 1089446005628 Alpha/beta hydrolase; Region: Abhydrolase_8; pfam06259 1089446005629 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 1089446005630 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 1089446005631 NAD binding site [chemical binding]; other site 1089446005632 substrate binding site [chemical binding]; other site 1089446005633 catalytic Zn binding site [ion binding]; other site 1089446005634 tetramer interface [polypeptide binding]; other site 1089446005635 structural Zn binding site [ion binding]; other site 1089446005636 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1089446005637 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1089446005638 NAD(P) binding site [chemical binding]; other site 1089446005639 catalytic residues [active] 1089446005640 Endo-beta-N-acetylglucosaminidases are bacterial chitinases that hydrolyze the chitin core of various asparagine (N)-linked glycans and glycoproteins. The endo-beta-N-acetylglucosaminidases have a glycosyl hydrolase family 18 (GH18) catalytic domain; Region: GH18_EndoS-like; cd06542 1089446005641 active site 1089446005642 Helix-Turn-Helix DNA binding domain of the HspR transcription regulator; Region: HTH_HspR; cd04766 1089446005643 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1089446005644 DNA binding residues [nucleotide binding] 1089446005645 chaperone protein DnaJ; Provisional; Region: PRK14279 1089446005646 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1089446005647 HSP70 interaction site [polypeptide binding]; other site 1089446005648 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 1089446005649 Zn binding sites [ion binding]; other site 1089446005650 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 1089446005651 dimer interface [polypeptide binding]; other site 1089446005652 Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576 1089446005653 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 1089446005654 dimer interface [polypeptide binding]; other site 1089446005655 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 1089446005656 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 1089446005657 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 1089446005658 nucleotide binding site [chemical binding]; other site 1089446005659 NEF interaction site [polypeptide binding]; other site 1089446005660 SBD interface [polypeptide binding]; other site 1089446005661 Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827 1089446005662 active site 1089446005663 catalytic site [active] 1089446005664 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1089446005665 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1089446005666 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1089446005667 cell division ATP-binding protein FtsE; Region: FtsE; TIGR02673 1089446005668 Walker A/P-loop; other site 1089446005669 ATP binding site [chemical binding]; other site 1089446005670 Q-loop/lid; other site 1089446005671 ABC transporter signature motif; other site 1089446005672 Walker B; other site 1089446005673 D-loop; other site 1089446005674 H-loop/switch region; other site 1089446005675 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1089446005676 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1089446005677 putative PBP binding loops; other site 1089446005678 dimer interface [polypeptide binding]; other site 1089446005679 ABC-ATPase subunit interface; other site 1089446005680 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 1089446005681 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1089446005682 Walker A/P-loop; other site 1089446005683 ATP binding site [chemical binding]; other site 1089446005684 Q-loop/lid; other site 1089446005685 ABC transporter signature motif; other site 1089446005686 Walker B; other site 1089446005687 D-loop; other site 1089446005688 H-loop/switch region; other site 1089446005689 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1089446005690 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1089446005691 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1089446005692 dimer interface [polypeptide binding]; other site 1089446005693 conserved gate region; other site 1089446005694 putative PBP binding loops; other site 1089446005695 ABC-ATPase subunit interface; other site 1089446005696 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 1089446005697 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 1089446005698 adrenodoxin reductase; Provisional; Region: PTZ00188 1089446005699 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 1089446005700 4Fe-4S binding domain; Region: Fer4; cl02805 1089446005701 Cysteine-rich domain; Region: CCG; pfam02754 1089446005702 Cysteine-rich domain; Region: CCG; pfam02754 1089446005703 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 1089446005704 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1089446005705 dimerization interface [polypeptide binding]; other site 1089446005706 putative DNA binding site [nucleotide binding]; other site 1089446005707 putative Zn2+ binding site [ion binding]; other site 1089446005708 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1089446005709 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1089446005710 Walker A/P-loop; other site 1089446005711 ATP binding site [chemical binding]; other site 1089446005712 Q-loop/lid; other site 1089446005713 ABC transporter signature motif; other site 1089446005714 Walker B; other site 1089446005715 D-loop; other site 1089446005716 H-loop/switch region; other site 1089446005717 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 1089446005718 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1089446005719 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1089446005720 putative PBP binding regions; other site 1089446005721 ABC-ATPase subunit interface; other site 1089446005722 proposed F420-0 ABC transporter, periplasmic F420-0 binding protein; Region: F420-O_ABCperi; TIGR03868 1089446005723 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1089446005724 intersubunit interface [polypeptide binding]; other site 1089446005725 UreD urease accessory protein; Region: UreD; cl00530 1089446005726 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1089446005727 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 1089446005728 UreF; Region: UreF; pfam01730 1089446005729 urease accessory protein UreE; Provisional; Region: ureE; PRK13261 1089446005730 UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571 1089446005731 dimer interface [polypeptide binding]; other site 1089446005732 catalytic residues [active] 1089446005733 urease subunit alpha; Reviewed; Region: ureC; PRK13207 1089446005734 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 1089446005735 subunit interactions [polypeptide binding]; other site 1089446005736 active site 1089446005737 flap region; other site 1089446005738 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 1089446005739 gamma-beta subunit interface [polypeptide binding]; other site 1089446005740 alpha-beta subunit interface [polypeptide binding]; other site 1089446005741 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 1089446005742 alpha-gamma subunit interface [polypeptide binding]; other site 1089446005743 beta-gamma subunit interface [polypeptide binding]; other site 1089446005744 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1089446005745 EamA-like transporter family; Region: EamA; pfam00892 1089446005746 EamA-like transporter family; Region: EamA; pfam00892 1089446005747 aminotransferase AlaT; Validated; Region: PRK09265 1089446005748 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1089446005749 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1089446005750 homodimer interface [polypeptide binding]; other site 1089446005751 catalytic residue [active] 1089446005752 YibE/F-like protein; Region: YibE_F; pfam07907 1089446005753 lysyl-tRNA synthetase; Provisional; Region: lysS; PRK02983 1089446005754 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 1089446005755 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 1089446005756 dimer interface [polypeptide binding]; other site 1089446005757 putative anticodon binding site; other site 1089446005758 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1089446005759 motif 1; other site 1089446005760 dimer interface [polypeptide binding]; other site 1089446005761 active site 1089446005762 motif 2; other site 1089446005763 motif 3; other site 1089446005764 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 1089446005765 Protein of unknown function (DUF998); Region: DUF998; pfam06197 1089446005766 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 1089446005767 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1089446005768 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 1089446005769 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 1089446005770 trimer interface [polypeptide binding]; other site 1089446005771 active site 1089446005772 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1089446005773 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 1089446005774 NAD(P) binding site [chemical binding]; other site 1089446005775 catalytic residues [active] 1089446005776 Uncharacterized vancomycin resistance protein [Defense mechanisms]; Region: COG2720 1089446005777 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 1089446005778 VanW like protein; Region: VanW; pfam04294 1089446005779 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 1089446005780 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 1089446005781 Domain of unknown function (DUF3367); Region: DUF3367; pfam11847 1089446005782 Acyltransferase family; Region: Acyl_transf_3; pfam01757 1089446005783 Protein of unknown function (DUF3068); Region: DUF3068; pfam11271 1089446005784 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1089446005785 S-adenosylmethionine binding site [chemical binding]; other site 1089446005786 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819 1089446005787 active site 1089446005788 substrate-binding site [chemical binding]; other site 1089446005789 metal-binding site [ion binding] 1089446005790 GTP binding site [chemical binding]; other site 1089446005791 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1089446005792 S-adenosylmethionine binding site [chemical binding]; other site 1089446005793 LabA_like proteins; Region: LabA_like; cd06167 1089446005794 putative metal binding site [ion binding]; other site 1089446005795 MMPL family; Region: MMPL; pfam03176 1089446005796 MMPL family; Region: MMPL; pfam03176 1089446005797 Predicted integral membrane protein [Function unknown]; Region: COG0392 1089446005798 Protein of unknown function (DUF3054); Region: DUF3054; pfam11255 1089446005799 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1089446005800 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 1089446005801 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 1089446005802 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1089446005803 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1089446005804 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1089446005805 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1089446005806 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1089446005807 active site 1089446005808 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1089446005809 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 1089446005810 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07769 1089446005811 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 1089446005812 acyl-activating enzyme (AAE) consensus motif; other site 1089446005813 active site 1089446005814 Cutinase; Region: Cutinase; pfam01083 1089446005815 Putative esterase; Region: Esterase; pfam00756 1089446005816 S-formylglutathione hydrolase; Region: PLN02442 1089446005817 LGFP repeat; Region: LGFP; pfam08310 1089446005818 Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479 1089446005819 LGFP repeat; Region: LGFP; pfam08310 1089446005820 LGFP repeat; Region: LGFP; pfam08310 1089446005821 Protein of unknown function (DUF2029); Region: DUF2029; pfam09594 1089446005822 Predicted esterase [General function prediction only]; Region: COG0627 1089446005823 phosphoribose diphosphate:decaprenyl-phosphate phosphoribosyltransferase; Provisional; Region: PRK12324 1089446005824 UbiA prenyltransferase family; Region: UbiA; pfam01040 1089446005825 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1089446005826 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 1089446005827 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 1089446005828 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1089446005829 Repair protein; Region: Repair_PSII; pfam04536 1089446005830 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 1089446005831 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1089446005832 active site 1089446005833 Glycerophosphodiester phosphodiesterase domain of putative Silicibacter pomeroyi glycerophosphodiester phosphodiesterase and similar proteins; Region: GDPD_SpGDE_like; cd08567 1089446005834 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 1089446005835 active site 1089446005836 catalytic site [active] 1089446005837 metal binding site [ion binding]; metal-binding site 1089446005838 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 1089446005839 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1089446005840 UDP-galactopyranose mutase; Region: GLF; pfam03275 1089446005841 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1089446005842 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1089446005843 Walker A/P-loop; other site 1089446005844 ATP binding site [chemical binding]; other site 1089446005845 Q-loop/lid; other site 1089446005846 ABC transporter signature motif; other site 1089446005847 Walker B; other site 1089446005848 D-loop; other site 1089446005849 H-loop/switch region; other site 1089446005850 FecCD transport family; Region: FecCD; pfam01032 1089446005851 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1089446005852 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1089446005853 putative PBP binding regions; other site 1089446005854 ABC-ATPase subunit interface; other site 1089446005855 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 1089446005856 Periplasmic binding protein YvrC. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria and archaea. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: YvrC; cd01143 1089446005857 putative binding site residues; other site 1089446005858 Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479 1089446005859 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 1089446005860 amidase catalytic site [active] 1089446005861 Zn binding residues [ion binding]; other site 1089446005862 substrate binding site [chemical binding]; other site 1089446005863 LGFP repeat; Region: LGFP; pfam08310 1089446005864 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1089446005865 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1089446005866 active site 1089446005867 motif I; other site 1089446005868 motif II; other site 1089446005869 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1089446005870 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1089446005871 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1089446005872 putative acyl-acceptor binding pocket; other site 1089446005873 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 1089446005874 seryl-tRNA synthetase; Provisional; Region: PRK05431 1089446005875 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 1089446005876 dimer interface [polypeptide binding]; other site 1089446005877 active site 1089446005878 motif 1; other site 1089446005879 motif 2; other site 1089446005880 motif 3; other site 1089446005881 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1089446005882 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1089446005883 DNA-binding site [nucleotide binding]; DNA binding site 1089446005884 UTRA domain; Region: UTRA; pfam07702 1089446005885 Septum formation; Region: Septum_form; pfam13845 1089446005886 Septum formation; Region: Septum_form; pfam13845 1089446005887 Minimal MMP-like domain found in Acidothermus cellulolyticus hypothetical protein ACEL2062 and similar protein; Region: MMP_ACEL2062; cd12952 1089446005888 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1089446005889 catalytic core [active] 1089446005890 Prephenate dehydratase; Region: PDT; pfam00800 1089446005891 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 1089446005892 putative L-Phe binding site [chemical binding]; other site 1089446005893 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 1089446005894 Amidase; Region: Amidase; cl11426 1089446005895 CAAX protease self-immunity; Region: Abi; pfam02517 1089446005896 Transcriptional regulator [Transcription]; Region: LytR; COG1316 1089446005897 Htaa; Region: HtaA; pfam04213 1089446005898 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 1089446005899 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_like_2; cd08582 1089446005900 putative active site [active] 1089446005901 catalytic site [active] 1089446005902 putative metal binding site [ion binding]; other site 1089446005903 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 1089446005904 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 1089446005905 Nucleoside recognition; Region: Gate; pfam07670 1089446005906 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 1089446005907 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 1089446005908 active site 1089446005909 catalytic motif [active] 1089446005910 Zn binding site [ion binding]; other site 1089446005911 thymidine phosphorylase; Reviewed; Region: deoA; PRK05820 1089446005912 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1089446005913 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 1089446005914 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941 1089446005915 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 1089446005916 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 1089446005917 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1089446005918 NAD binding site [chemical binding]; other site 1089446005919 dimer interface [polypeptide binding]; other site 1089446005920 substrate binding site [chemical binding]; other site 1089446005921 methionine sulfoxide reductase A; Provisional; Region: PRK00058 1089446005922 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 1089446005923 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 1089446005924 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 1089446005925 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1089446005926 Predicted flavoprotein [General function prediction only]; Region: COG0431 1089446005927 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1089446005928 putative substrate translocation pore; other site 1089446005929 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1089446005930 Abi-like protein; Region: Abi_2; pfam07751 1089446005931 sugar phosphate antiporter; Reviewed; Region: uhpT; PRK09556 1089446005932 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1089446005933 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1089446005934 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in mouse RS21-C6 protein and its homologs; Region: NTP-PPase_RS21-C6_like; cd11537 1089446005935 homodimer interface [polypeptide binding]; other site 1089446005936 chemical substrate binding site [chemical binding]; other site 1089446005937 oligomer interface [polypeptide binding]; other site 1089446005938 metal binding site [ion binding]; metal-binding site 1089446005939 Protein of unknown function (DUF2029); Region: DUF2029; cl09812 1089446005940 Predicted nuclease (RecB family) [General function prediction only]; Region: COG2251 1089446005941 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 1089446005942 Lsr2; Region: Lsr2; pfam11774 1089446005943 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1089446005944 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1089446005945 active site 1089446005946 phosphorylation site [posttranslational modification] 1089446005947 intermolecular recognition site; other site 1089446005948 dimerization interface [polypeptide binding]; other site 1089446005949 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1089446005950 DNA binding residues [nucleotide binding] 1089446005951 dimerization interface [polypeptide binding]; other site 1089446005952 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1089446005953 Histidine kinase; Region: HisKA_3; pfam07730 1089446005954 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1089446005955 ATP binding site [chemical binding]; other site 1089446005956 Mg2+ binding site [ion binding]; other site 1089446005957 G-X-G motif; other site 1089446005958 Domain of unknown function (DUF2020); Region: DUF2020; pfam09449 1089446005959 Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is cleaved...; Region: Sortase_D_5; cd05830 1089446005960 active site 1089446005961 catalytic site [active] 1089446005962 putative inner membrane protein translocase component YidC; Validated; Region: PRK00247 1089446005963 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 1089446005964 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1089446005965 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1089446005966 Uncharacterized member of the PurR regulon [General function prediction only]; Region: yhhQ; COG1738 1089446005967 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1089446005968 Ligand Binding Site [chemical binding]; other site 1089446005969 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1089446005970 Ligand Binding Site [chemical binding]; other site 1089446005971 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 1089446005972 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1089446005973 active site 1089446005974 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 1089446005975 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1089446005976 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1089446005977 Walker A/P-loop; other site 1089446005978 ATP binding site [chemical binding]; other site 1089446005979 Q-loop/lid; other site 1089446005980 ABC transporter signature motif; other site 1089446005981 Walker B; other site 1089446005982 D-loop; other site 1089446005983 H-loop/switch region; other site 1089446005984 Predicted transcriptional regulators [Transcription]; Region: COG1725 1089446005985 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1089446005986 DNA-binding site [nucleotide binding]; DNA binding site 1089446005987 LabA_like proteins; Region: LabA_like; cd06167 1089446005988 putative metal binding site [ion binding]; other site 1089446005989 Uncharacterized conserved protein [Function unknown]; Region: COG1432 1089446005990 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 1089446005991 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1089446005992 catalytic residues [active] 1089446005993 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1089446005994 metal-binding site [ion binding] 1089446005995 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1089446005996 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1089446005997 metal-binding site [ion binding] 1089446005998 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1089446005999 benzoate transport; Region: 2A0115; TIGR00895 1089446006000 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1089446006001 putative substrate translocation pore; other site 1089446006002 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1089446006003 replicative DNA helicase; Provisional; Region: PRK05636 1089446006004 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 1089446006005 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 1089446006006 Walker A motif; other site 1089446006007 ATP binding site [chemical binding]; other site 1089446006008 Walker B motif; other site 1089446006009 DNA binding loops [nucleotide binding] 1089446006010 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 1089446006011 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 1089446006012 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 1089446006013 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 1089446006014 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 1089446006015 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1089446006016 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1089446006017 dimer interface [polypeptide binding]; other site 1089446006018 ssDNA binding site [nucleotide binding]; other site 1089446006019 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1089446006020 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 1089446006021 Predicted integral membrane protein [Function unknown]; Region: COG5650 1089446006022 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 1089446006023 Transglycosylase; Region: Transgly; pfam00912 1089446006024 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1089446006025 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1089446006026 MarR family; Region: MarR; pfam01047 1089446006027 MarR family; Region: MarR_2; cl17246 1089446006028 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1089446006029 Ligand Binding Site [chemical binding]; other site 1089446006030 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1089446006031 Ligand Binding Site [chemical binding]; other site 1089446006032 short chain dehydrogenase; Provisional; Region: PRK08219 1089446006033 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1089446006034 NAD(P) binding site [chemical binding]; other site 1089446006035 active site 1089446006036 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 1089446006037 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 1089446006038 active site residue [active] 1089446006039 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1089446006040 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 1089446006041 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 1089446006042 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 1089446006043 dimerization interface [polypeptide binding]; other site 1089446006044 DPS ferroxidase diiron center [ion binding]; other site 1089446006045 ion pore; other site 1089446006046 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 1089446006047 N-terminal domain of the actinomycetal Nei1 and related DNA glycosylases; Region: AcNei1_N; cd08970 1089446006048 putative DNA binding site [nucleotide binding]; other site 1089446006049 catalytic residue [active] 1089446006050 putative H2TH interface [polypeptide binding]; other site 1089446006051 putative catalytic residues [active] 1089446006052 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1089446006053 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1089446006054 YjeF-related protein N-terminus; Region: YjeF_N; cl00318 1089446006055 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 1089446006056 putative substrate binding site [chemical binding]; other site 1089446006057 putative ATP binding site [chemical binding]; other site 1089446006058 Glycopeptide antibiotics resistance protein [Defense mechanisms]; Region: VanZ; COG4767 1089446006059 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 1089446006060 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 1089446006061 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 1089446006062 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 1089446006063 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 1089446006064 HIGH motif; other site 1089446006065 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1089446006066 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1089446006067 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1089446006068 active site 1089446006069 KMSKS motif; other site 1089446006070 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 1089446006071 tRNA binding surface [nucleotide binding]; other site 1089446006072 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1089446006073 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1089446006074 Walker A/P-loop; other site 1089446006075 ATP binding site [chemical binding]; other site 1089446006076 Q-loop/lid; other site 1089446006077 ABC transporter signature motif; other site 1089446006078 Walker B; other site 1089446006079 D-loop; other site 1089446006080 H-loop/switch region; other site 1089446006081 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1089446006082 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1089446006083 FtsX-like permease family; Region: FtsX; pfam02687 1089446006084 actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769 1089446006085 actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769 1089446006086 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1089446006087 Histidine kinase; Region: HisKA_3; pfam07730 1089446006088 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1089446006089 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1089446006090 active site 1089446006091 phosphorylation site [posttranslational modification] 1089446006092 intermolecular recognition site; other site 1089446006093 dimerization interface [polypeptide binding]; other site 1089446006094 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1089446006095 DNA binding residues [nucleotide binding] 1089446006096 actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769 1089446006097 putative ABC transporter-associated repeat protein; Region: anch_rpt_wall; TIGR03773 1089446006098 actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769 1089446006099 actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769 1089446006100 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 1089446006101 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 1089446006102 active site 1089446006103 trimer interface [polypeptide binding]; other site 1089446006104 allosteric site; other site 1089446006105 active site lid [active] 1089446006106 hexamer (dimer of trimers) interface [polypeptide binding]; other site 1089446006107 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 1089446006108 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1089446006109 active site 1089446006110 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 1089446006111 N-acetylmannosamine-6-phosphate 2-epimerase; Provisional; Region: PRK01130 1089446006112 putative active site cavity [active] 1089446006113 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1089446006114 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1089446006115 nucleotide binding site [chemical binding]; other site 1089446006116 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1089446006117 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1089446006118 DNA-binding site [nucleotide binding]; DNA binding site 1089446006119 FCD domain; Region: FCD; pfam07729 1089446006120 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1089446006121 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 1089446006122 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1089446006123 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1089446006124 dimer interface [polypeptide binding]; other site 1089446006125 conserved gate region; other site 1089446006126 putative PBP binding loops; other site 1089446006127 ABC-ATPase subunit interface; other site 1089446006128 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1089446006129 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1089446006130 dimer interface [polypeptide binding]; other site 1089446006131 conserved gate region; other site 1089446006132 putative PBP binding loops; other site 1089446006133 ABC-ATPase subunit interface; other site 1089446006134 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 1089446006135 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1089446006136 Walker A/P-loop; other site 1089446006137 ATP binding site [chemical binding]; other site 1089446006138 Q-loop/lid; other site 1089446006139 ABC transporter signature motif; other site 1089446006140 Walker B; other site 1089446006141 D-loop; other site 1089446006142 H-loop/switch region; other site 1089446006143 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 1089446006144 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 1089446006145 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1089446006146 Walker A/P-loop; other site 1089446006147 ATP binding site [chemical binding]; other site 1089446006148 Q-loop/lid; other site 1089446006149 ABC transporter signature motif; other site 1089446006150 Walker B; other site 1089446006151 D-loop; other site 1089446006152 H-loop/switch region; other site 1089446006153 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1089446006154 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 1089446006155 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 1089446006156 inhibitor site; inhibition site 1089446006157 active site 1089446006158 dimer interface [polypeptide binding]; other site 1089446006159 catalytic residue [active] 1089446006160 aldose 1-epimerase superfamily; Region: Aldose_epim; cl14648 1089446006161 active site 1089446006162 catalytic residues [active] 1089446006163 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4868 1089446006164 hypothetical protein; Provisional; Region: PRK13663 1089446006165 Domain of unknown function (DUF1508); Region: DUF1508; cl01356 1089446006166 Domain of unknown function (DUF4272); Region: DUF4272; pfam14094 1089446006167 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 1089446006168 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1089446006169 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 1089446006170 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210 1089446006171 substrate binding pocket [chemical binding]; other site 1089446006172 substrate-Mg2+ binding site; other site 1089446006173 aspartate-rich region 1; other site 1089446006174 aspartate-rich region 2; other site 1089446006175 phytoene desaturase; Region: crtI_fam; TIGR02734 1089446006176 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1089446006177 SdpI/YhfL protein family; Region: SdpI; pfam13630 1089446006178 anthranilate synthase component I; Provisional; Region: PRK13564 1089446006179 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 1089446006180 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1089446006181 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 1089446006182 Glutamine amidotransferase class-I; Region: GATase; pfam00117 1089446006183 glutamine binding [chemical binding]; other site 1089446006184 catalytic triad [active] 1089446006185 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1089446006186 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 1089446006187 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 1089446006188 bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase; Provisional; Region: PRK09427 1089446006189 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 1089446006190 active site 1089446006191 ribulose/triose binding site [chemical binding]; other site 1089446006192 phosphate binding site [ion binding]; other site 1089446006193 substrate (anthranilate) binding pocket [chemical binding]; other site 1089446006194 product (indole) binding pocket [chemical binding]; other site 1089446006195 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 1089446006196 active site 1089446006197 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 1089446006198 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 1089446006199 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1089446006200 catalytic residue [active] 1089446006201 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 1089446006202 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 1089446006203 substrate binding site [chemical binding]; other site 1089446006204 active site 1089446006205 catalytic residues [active] 1089446006206 heterodimer interface [polypeptide binding]; other site 1089446006207 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 1089446006208 iron-sulfur cluster [ion binding]; other site 1089446006209 [2Fe-2S] cluster binding site [ion binding]; other site 1089446006210 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 1089446006211 SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593 1089446006212 Branched-chain amino acid transport protein (AzlD); Region: AzlD; cl00735 1089446006213 hypothetical protein; Validated; Region: PRK00228 1089446006214 tRNA adenylyltransferase; Region: tRNA_CCA_actino; TIGR02692 1089446006215 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 1089446006216 active site 1089446006217 NTP binding site [chemical binding]; other site 1089446006218 metal binding triad [ion binding]; metal-binding site 1089446006219 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 1089446006220 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1089446006221 Zn2+ binding site [ion binding]; other site 1089446006222 Mg2+ binding site [ion binding]; other site 1089446006223 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 1089446006224 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 1089446006225 active site 1089446006226 Ap6A binding site [chemical binding]; other site 1089446006227 nudix motif; other site 1089446006228 metal binding site [ion binding]; metal-binding site 1089446006229 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 1089446006230 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 1089446006231 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 1089446006232 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1089446006233 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1089446006234 DNA binding residues [nucleotide binding] 1089446006235 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 1089446006236 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1089446006237 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1089446006238 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1089446006239 catalytic residues [active] 1089446006240 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 1089446006241 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1089446006242 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1089446006243 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 1089446006244 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1089446006245 active site 1089446006246 metal binding site [ion binding]; metal-binding site 1089446006247 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 1089446006248 ParB-like nuclease domain; Region: ParBc; pfam02195 1089446006249 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1089446006250 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1089446006251 P-loop; other site 1089446006252 Magnesium ion binding site [ion binding]; other site 1089446006253 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1089446006254 Magnesium ion binding site [ion binding]; other site 1089446006255 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 1089446006256 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 1089446006257 putative inner membrane protein translocase component YidC; Provisional; Region: PRK03449 1089446006258 Haemolytic domain; Region: Haemolytic; pfam01809 1089446006259 ribonuclease P; Reviewed; Region: rnpA; PRK03459 1089446006260 Ribosomal protein L34; Region: Ribosomal_L34; cl00370